<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFQ1</accession>
    <name>A0A6A8FFQ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fsa</name>
        <name evidence="9" type="synonym">tal</name>
        <name evidence="10" type="ORF">FIO04_00775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="WJXC01000022">
        <property type="protein sequence ID" value="MRN68215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="221" mass="24354" checksum="45819EF883FDE564" modified="2020-06-17" version="1">MKIFLDSANLHSIKKYNDMGLIDGITTNPTLLSKEKEDPAALMREIVRIVKGPVSLEVVGTKTEEMVEEAHRLMKYGQNVVVKIPMMPDGLRAIRQLTQEGIPTNVTLVFSANQAILAAKAGAAYVSPFIGRLDDGGQDGTDLIKQIVQIFRNYHFNTEVLVASVRHPLHIIEAGKIGADIVTLPPDILARMIIHPLTDKGLAAFLEDWEKLKKENPNVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFS8</accession>
    <name>A0A6A8FFS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="149" mass="16768" checksum="A676080EE2FCE240" modified="2020-06-17" version="1">MPIYSLIIYRAYPALQSARGMKQTVMVSKPKLFLIISALTTAVLLPLAILPHIDHPFFVYRVSLHMASIIISVFLIVVSILTYRRTGSIKILYTSIAFLSLLVVELIFLLQIMPGTSRIMIPMAYRELPHILLLAMLALFGLGVLRVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG82</accession>
    <name>A0A6A8FG82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M24 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_01115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000034">
        <property type="protein sequence ID" value="MRN68281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="204" mass="22043" checksum="16FE8D7EFE179C07" modified="2020-06-17" version="1" fragment="single">IGLSERALQAKIIFEAMQMGANSACLKSTLNPLIIASGPNGALPHAQVSDRKFVDGDMVVVDLTLRYASYIADATRTFALGTAASETKEAYELVKQSQQLGINCAEEGVVCERVDKECRALISNGGYGNQFIHSTGHGIGLDVHEPPWLRTPNQQVLKRNMAITIEPGIYLNGKFGVRIEDSVIVDNGQAKNLNAFTKDLLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG88</accession>
    <name>A0A6A8FG88_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rrp42</name>
        <name evidence="5" type="ORF">FIO04_01815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000059">
        <property type="protein sequence ID" value="MRN68415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="3">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="4">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="275" mass="29687" checksum="BEC065D5A67E9F50" modified="2020-06-17" version="1">MSSSRRSTIIVEHLRKQQMWDSISKGKRLDGRALDEIRPIEIEVGLIKKANGSARVKLGNSEVVAGVKVETGEPFEGLENKGALILSAEVLPTASPYIEPGPPDEETVELARVVDRGIRESEMLDLSKLALIPGEIVYVIFVDCSVINADGNLFDATSYAAVSALMNSKLPVFEIRDRKAVDTGEKQNPPLTTVPVSITAVRIGESVILDPTAEEEACMDARITITTNSDQNFAAVQKGSTGAFAVEQLKRAAATARIKGEEIRAKLRESTKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGE0</accession>
    <name>A0A6A8FGE0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_02125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000073">
        <property type="protein sequence ID" value="MRN68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="306" mass="34526" checksum="1B126B9C12179B4C" modified="2020-06-17" version="1">MEIRDDSKRTFDEAIGLSTYSTSKAGVLSYVSIFENLWLQTELYQQIKESSTRLQLANEQLAIANEQLKVHDKMQQEFINVAAHELRTPIQPILSLTELLRSKIMDSNQRELLDVIIRNAKRLQRLSDNILDVTRIESGKLKLSKERFDLNEKIHNIIRDVKTQISVANDVQITLSPSDKSEMSIFVEADKVRIFQVISNLLSNAIKFTDKEGTISISLKKREGTEGENKKEEEVIVSIRDSGAGIPSEIRHRLFSKFATKSDSGTGLGLFISKSIVEAHGGKIWVENNANGRGTTFYFTLPLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGK7</accession>
    <name>A0A6A8FGK7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TPP_enzyme_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000098">
        <property type="protein sequence ID" value="MRN68565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="226" mass="24689" checksum="E93C512539341DD6" modified="2020-06-17" version="1">MGVDSRIGSNLSDELDDNAIISVDCGTNTSWAARFIDIRKGMKFSVSGTLSSMANGLPYAIAAQIAFPERQSVAFVGDGGLTMLMGEFATAVQYSLPIKVIVIKNNTLGLIRWEQMGFLGNPEYGVEFSPIDYVKFAEACGGKGYAISEPSEVKSTMHQAMKERKPTIVEAYVDPFEPPMPPKVEMGFVRNLAESFAKGQPYVGRIGLTLFRDQVHSILKNLHSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGZ6</accession>
    <name>A0A6A8FGZ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HB_MCP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000082">
        <property type="protein sequence ID" value="MRN68504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4HB_MCP_1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="107" mass="11780" checksum="9060D56E20BE5E01" modified="2020-06-17" version="1">MGQFSTIKSKLVIGFFSIASFVVIVGTVGFVNLVHINSAFNVVTNDTLPKLLVLDNIQSSINKISSDIVGFALGSSEAKALHQERLNDTRQQDIDYVYRSIWQDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH04</accession>
    <name>A0A6A8FH04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Decarboxylating 6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gnd</name>
        <name evidence="4" type="ORF">FIO04_02320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000084">
        <property type="protein sequence ID" value="MRN68514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="312" mass="34448" checksum="789F67D3C2D1D4E9" modified="2020-06-17" version="1">MRLGIVGLGKMGGNLALQAVEKNIAVIGKARSTKPDLERNGVKVVRDYESFVSYLDIPRVIYLSLPAGPTIDTVLKEMLPYLERGDVVMDGGNSFYMDSIKREKELFDKGIYFLDCGTSGGLEGARYGACFMVGGRAEGIKIAEHILKTLAVNEDGYVCTGQPGSGHFVKLVHNGIEFGMLQSIGEGVSLLLQGNGFNLDLVQIFKNWSNGSVIRGWLVELMEKGLREQDYGKIPSYIEDTGEVNWLVEDAINKEIPIPVISQSVMELFKSRSKDSDAYKSIALMRHGFGGHPFGKDENIKKERKTSRITRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH06</accession>
    <name>A0A6A8FH06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_02405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000089">
        <property type="protein sequence ID" value="MRN68531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="94"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="302"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="438" mass="48103" checksum="8F115426C21A83BE" modified="2020-06-17" version="1" fragment="single">LLIATLVLSYLSSSFKDRNNEALAQQYIQTIKYRNLVIDLGNGLKTNAQLTLPAIGKGPFPGVLLIPGSGAADKNESLGYVLKNKPQPVQPLLQIAKYLSERGFTVLRYDKRGIGGNFTILDKNVWRNMTFNDLKQDAEKALNVLMAQPEVNDTQKITIIGHSEGAIIAPRVAVDNPTKVRNIVLIGAQAQNLRDNVYFQYVYLPILYAEKVLDHKHNGLISLQEASKDPTFEIISGKVISHLLQKQITNNSNATSTRIIQQQQSKGNSTNNNAEISIDKGLKPLLLKRIESLTTYDPKCVDLEGCPTYVKSHFALGSTLNMIGNVSSTTGILILQGENDTNTPVQQAFMLQQRLTELNHPDHTSITYPGLGHELSPAIGYFVPGSGMYGLQKAGPIEEYALADLYAWLEAHSGFTHPYRTLLVANGTLGTNMTSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH33</accession>
    <name>A0A6A8FH33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO02_10700</name>
        <name evidence="9" type="ORF">FIO04_02560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000296">
        <property type="protein sequence ID" value="MRN41496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000097">
        <property type="protein sequence ID" value="MRN68561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN41496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="157" mass="17728" checksum="B8E5D4611033E78B" modified="2020-06-17" version="1">MRTSNRRGLFKTAEEDRNNREGLKGWLNPARYGWERVSYWLQRLTGLFLLIYFIGHIYETSSLTGGAGAWNAMLQFTETPWGHLFLILVIGTSTYHSTNGIRLIFTEAGRGLGRPGRPDYPYDALSLNYRQKSGIWIALILAAVAMFYGGNVLFGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH93</accession>
    <name>A0A6A8FH93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO03_05745</name>
        <name evidence="11" type="ORF">FIO04_00550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="WJXD01000197">
        <property type="protein sequence ID" value="MRN61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000014">
        <property type="protein sequence ID" value="MRN68172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="246" mass="26459" checksum="65C8A9FB478F44D4" modified="2020-06-17" version="1">MAHKIEDYIQSEVKKYGTLCFPLIDSENSAGAASIAKKVEGMGASAVLVGGSSAIDQLELTEIVSSIKLQINIPVILFPGNVTGVSPRADAILFSTLLNSEDPYFITEAQALGALSVKKYNIEPLPTGYLIIGEGTTAWFIGRARGIPFNKYRIAVMYSLAAQYLGLRFLYLEAGSGAMQSISPQMVSAVRKHYEGILIVGGGIRAPETAKEIAKAGADVIVISTMIEQDGSWEDKLSTIIKQIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHB9</accession>
    <name>A0A6A8FHB9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenosine 5'-phosphosulfate reductase</fullName>
            <ecNumber evidence="5">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_00585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000016">
        <property type="protein sequence ID" value="MRN68178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="9">
        <location>
            <begin position="39"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="247" mass="28876" checksum="28430EFECCB968FD" modified="2020-06-17" version="1">MESKPTIPQLKQIARQMENKSAREVLRWAVDTYGLRIGLASSFGPEDVVLIDIMIKINKEKTRIFTLDTGRLNQETYDLMDTIRKKYAIQIEVFFPEQKEVEQMVQIKGMNLMYESVENRKLCCEIRKVHSINRALSKLDGWITGLRREQAITRTHIQKVEIDSSHDNIVKVNPVADWTNEMVWDYIHKNSVPYNKLHDIGYMSIGCEPCTRAVPPNEDPRSGRWWWETGTHKECGLHWDDSKQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHH8</accession>
    <name>A0A6A8FHH8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp41</name>
        <name evidence="8" type="ORF">FIO04_01820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000059">
        <property type="protein sequence ID" value="MRN68416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="6">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="7">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="246" mass="27392" checksum="BF453AA780C17757" modified="2020-06-17" version="1">MTQTRSLIDENGKRTDGRTGDQLREIKITVGVIKNADGSAFIEFGMNKIVVGVYGPREVHPKHMALPDRCVLRCRYHMTPFSTDTRKNPAPSRREVEISKVMREALEPSLMLEDYPRAAIDVYVEVLQADGGSRCAGITAASVALADAGINMRDMVSACAAGKVDDRIVLDINDTEDKEGDADMPVAYMSHLEQVTLLQLDGVLNEDQFDQCLDEAVKGCKMVYEVQRKALMQKYFGNETELKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHI6</accession>
    <name>A0A6A8FHI6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">leuD</name>
        <name evidence="10" type="ORF">FIO02_07835</name>
        <name evidence="11" type="ORF">FIO04_00945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="4"/>
    <dbReference type="EMBL" id="WJXE01000156">
        <property type="protein sequence ID" value="MRN40936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000028">
        <property type="protein sequence ID" value="MRN68248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="9">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN40936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="203" mass="23581" checksum="B678F1FAA0A71FFC" modified="2020-06-17" version="1">MEPIRIIKSKATPLDMANIDTDQIIPKQFLKLIQKTGYGKYLFYDWRFDKNGKLKPNFVLNDPKYQGREILVTRDNFGSGSSREHAVWALEDYGFKAIIAPSFADIFYSNCFKNGILPIKLNASDVEYLIRDADDEEIKIDLAVQEVLVAHKILHFQIDESRKKKLLEGLDDIDITLNMESQIAEYEKKKSTSDHMIFTWKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHP3</accession>
    <name>A0A6A8FHP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO02_10300</name>
        <name evidence="7" type="ORF">FIO04_03490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000269">
        <property type="protein sequence ID" value="MRN41418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000155">
        <property type="protein sequence ID" value="MRN68744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN41418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="433" mass="47130" checksum="0587284BF78766A2" modified="2020-06-17" version="1">MATVPEEFRFGNFLASIIWVILIVIVVLTLVILPLTFIVLFYVPLPPVNGEVLTPYLFLSMVVDPTRTLPIVKYLIHTTPFKVIVFPGFVFAAIIAAATIFVERKFLAKMQLRVGPLYAGVWGVGEGILQLAADGLKVISKEILIPSGADKPIFWAAPIAFVATAAAVVALIPVAPGWVVSNTSVGLVAVFAILGFFPLIALLFSWASNSKYPFIGGLRALHQMIAFEIPFILSALSVVILAGSLNLTDIAKSQHPFWFILFLPISAFVFFISSLAELERVPFDLPEAESEIVAGWLTETSGMIYGLIQLGSYLKVYALSALFVILFLGGWSGPQIFPHQLGPPDAIPLVKVLTLQGLYNAVTVNAIFWFLVKTIGIIMLMILPRGISPRIRIDILLHTGWYKLIVLAFVNMFVALALIYAGILGPGGSLSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHP6</accession>
    <name>A0A6A8FHP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucyl aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_00070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="5">
        <location>
            <begin position="207"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="364" mass="39014" checksum="90860D01575AEB25" modified="2020-06-17" version="1" fragment="single">SFNRYKTSGKEATTIPAQATIVVNSDSAKFQAVVDKVNLITQAVNYARDLSNLPPNECPPSQIASLALALDGEYGIKTRILERYEMESIGLNGIVSVGKGSNNPPKLIILEYYGNADHQKPYLLVGKAVTFDTGGISLKPGDKMDEMKFDKCGGCSVLGILKAIASLGLPVNVIGIIPSVENMPSSTSYRPGDIIRMYNGKTVEILNTDAEGRIILADAMAYGVAIYNPQAIIDLATLTGACVIALGANVAAVIGTSKYLAERLSKISEKTGERIWDLPLHDEYHEQIKSTVADLKNIGGRPGGAITAAAFLSNFTNDIPWVHLDIAGTAWTQEGTFERSYNPKGATGFGVRTVVKFLMEAPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHT8</accession>
    <name>A0A6A8FHT8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000258">
        <property type="protein sequence ID" value="MRN69015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="58" mass="6719" checksum="D009DEB81EFFF77C" modified="2020-06-17" version="1">MDFTQRKIIVSDNINDNAKRMKDSVEPFPDCSAKSEMMTLIENTRKDLLKKLDDITTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHW0</accession>
    <name>A0A6A8FHW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_04970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000266">
        <property type="protein sequence ID" value="MRN69035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="407"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="590" mass="65316" checksum="4B62C253CE9A3180" modified="2020-06-17" version="1" fragment="single">MPQEVSGKKMDKKKAIFIALVITVIVLVVPLTIIISKGTSSNAAVIWNIGSISFTDLLTDSMSSIYRMFVALALSFIVAIIVGITAARKPLASRIIIPIVDILQSVPILGFFPAAIAFFITLFSGSPIGVELAAIFLIFTSMVWNMIFAVYESVLSIPPELIETSKSCRANPLLQFRRLYLPASIPKLIYNSILSWAAGWYFLTAAEIISVGSNTFTLPGLGSLLSKSVASGQYIEALVAIAVLILIIMLTDFFIWRPLESYSNRFRYDYSTSSPDLARHHIMQDSNNNIARLFLRRVAFQPIHLRIINPRPLIHIKSNLLIRTLGKLVSAFEFRIFPTVHHWFDNKRNLRLFVSITLSVLTMSAILVIVLEGGVIYKSFSALSNMYFSLYKDPRSAKIVSQIPLALLLSYLRLASAYLITLAWTIPVAIKIAHNPNFERIMPLFQTFAAIPATAFFPFMAILVAYIPGGLEFPSILLILTGMQWYILFNLIGGVRSISGDIEEAAKALRADKGQYIRRVLFPSIYPSFITGSITGWGGGWNSLIVAEFLIYGNKTYSVLGIGSLLDKAAYTLGNTVLLFLIVGVMIAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHX8</accession>
    <name>A0A6A8FHX8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000054">
        <property type="protein sequence ID" value="MRN68388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="297" mass="34036" checksum="162461B57E13B417" modified="2020-06-17" version="1">MDEVKRKIIDALQDNSIGLSGVELASTTGINRMTITKYLNILATMRLIKKKRVGSVNVWFVEPGTADYEFPVNYLEVQQKFMDAIVIGDGDQARNILISVINSNIELLRLLTDIIAPTVNTVNELYIRGRLGKTERIYLLNLILELIDLLKFTIQSDSRKRGAYSFFVAASEDRIYHAKIGALALQILGFRTSYIGNVEQHIDPFFDIDFQRYIMKLWDKKKGLLIICIYSSEEGSLRFLYAATRAMKAKLKAEVRIVIFTTPELRNTLESLGTDFIANDLNSLIEWVEREYHRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHY0</accession>
    <name>A0A6A8FHY0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000186">
        <property type="protein sequence ID" value="MRN68844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="627" mass="67463" checksum="9E851526027CF196" modified="2020-06-17" version="1">MIGIGAYNQMIIQRDNLKGVLVAPTASIAGGGGQSKIDKSVAKKGSESESGSSNHYLNGNAVISKFAKTTKAEAFVGLALLAAVAVLVNTGLPAGEFQTQLQQLQQQQQNLPGLNIANAFTTQQQGFTTTNFVENNDRVTLSINPYTPGNNNFKISYTDSNGNPIDISSVQLRYTQTEKGIGPITVDADKASKGIFSVNAAFGLAGPWNLQIEAMQAKANALDIVTEYNLFVKPKLGDFVFSVKEYKMPANNAQPLFILYDKSRNLIWTGDSSINSGRIFDFNLNTTKYTEHKIAGTSLITSMALDPSSNDIWFIDPINKDLGIYKPGTNTAQLYKIPVQGVPSGIAVDSNSTNVWISLASANEILRFNIQSKSFSTPIKLPSMNAAPLGIIIDQSGQIWIAESGIGKLANIDPTKNYKVSEYAPIAGTNNTLKSPTALLADPTTGDIYISEHDGHAVSIFNPILKTFNQYPPLNPNGLPFGMTLDNNRNLWVAEHTINKIAVIDPRTGENKEVNIPQQSPFVQWITSDSHGNVWLAEQRGNSLAVITSTAKPSLSNSIASLPGASSTNKINNNQASIPSLGFSYAEIVGPSVAAGIILSALFYAKTVMDLKHSEQLVRKNGVRPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI01</accession>
    <name>A0A6A8FI01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000061">
        <property type="protein sequence ID" value="MRN68422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="91" mass="10362" checksum="12DC9556D8D5E899" modified="2020-06-17" version="1" fragment="single">MVLTLALLGSTMDKILIDAVRFDEVNSVNQGKFQFQSPDQRQKYIDTQTLLHIKTLGLDEPWYSPKRFANTLLELLTLDLGKSHFFTSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI03</accession>
    <name>A0A6A8FI03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000198">
        <property type="protein sequence ID" value="MRN68874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="56" mass="6618" checksum="CC6DE83DD2EFAA3C" modified="2020-06-17" version="1">MSKDDGSDAAKTRRQVDNAVCWLQKRYFTEEVKAERFNESAAHLFKVNKNDRNSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI33</accession>
    <name>A0A6A8FI33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000118">
        <property type="protein sequence ID" value="MRN68626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="90" mass="10088" checksum="1AAF79D0D7F332B8" modified="2020-06-17" version="1">MTPNSPTPPEISAFIQIRFKKKNEMYAVLRSLIADNTDFPNGLSIEMSPRDDDNNLLLCLSCKVGFETLLNTINELLEHISIAQKVISHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI34</accession>
    <name>A0A6A8FI34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF521 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000299">
        <property type="protein sequence ID" value="MRN69105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="AcnX_catalytic_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="387" mass="42157" checksum="522CE645C5622614" modified="2020-06-17" version="1">MELTGEEENMLRGERGESLAVAYRILLAIGEATEAERLIPVKWAHISGVNYNTIGDSGVDFLEEFSKSARVVIRTTINPMGFDQNKTVNLSENFTQKQMSIARSYHMLGTTTSFTCVPYEIFDIPEKGSAVSFAESNAAVFSNSILGLLTNRESALSALASSITGKSPYSNLLMDKFRHAKVTVKPDYELATELDYGLLGYFAGNTVSDNCIGINAGEEKLDTIKAKALSAAIGTSGSCGMFTKEDDTKQEIISCGKEEVTTIKDELNTAEDGDLIALGSPQLGLNELHLLAALIEGKRLTKRCIIFCARAIHNQAKHLGLIDRIEHAGGEFMCDSCTCLTPLITRADFDSVITNSVKAAYYLNHSNRVGVCLKDLKTIIKECADYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI77</accession>
    <name>A0A6A8FI77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000226">
        <property type="protein sequence ID" value="MRN68941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15452" checksum="FF06EFFA812D5B3E" modified="2020-06-17" version="1">MRVFIQDDHQLDQTEIAEAKRLSIDIVENDPLIEVRDDRRVSHRINLLSRSGKLYNTDVIFYHMGYNVQSQLAEQLGCQLDEGFIKINNKQKTTVANVYAAGDVDTDRHYVVLAVASGALAAISIYEDILKTALENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIB4</accession>
    <name>A0A6A8FIB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000091">
        <property type="protein sequence ID" value="MRN68538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="66" mass="7087" checksum="491CDEAB2589BC77" modified="2020-06-17" version="1" fragment="single">MYKAMGLSDEELKRPLIGVSTTSNEATPCNIHLGKLGQYAKDGVREAGCTPREFTTISVSDVITQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIC7</accession>
    <name>A0A6A8FIC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000258">
        <property type="protein sequence ID" value="MRN69014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="127" mass="14004" checksum="33E6F407AC44E622" modified="2020-06-17" version="1">MLAAIHLKFTAQATHPVVAARQVPTPSALLQALVVHQAVALPIRVVAAKRLQQDLLLLPVANHLLVLARIAQAQQARPVLALVNHAAHSLQQRKRSLVSHKQAAARIFLFFQPNRVNSLRYEKNQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FID0</accession>
    <name>A0A6A8FID0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_04565</name>
        <name evidence="3" type="ORF">FIO04_05780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000063">
        <property type="protein sequence ID" value="MRN40298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000343">
        <property type="protein sequence ID" value="MRN69195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="75"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="257" mass="29559" checksum="C4F121951C888CC6" modified="2020-06-17" version="1">MRVFGRWRKNSNNIPVSELDGNRRYSKPAIGQKRSLFDGIVGFDDIKELFDMSIRADKPVHLLLVGPPASAKSLFMSSLTKLERSYYVVGSSSTKSGIFDYLFEYRPRYFIIDEIEKMNKRDQTSLLNLMESGILSELKHNQKRTTQLKTWVYASCNSTEKLLPPLLTRFRDMHFKPYTEEEFVNIAVEILDREEGLDRDVATIIAEAVFNRLKSTNIRECIRIARLTHGDIDVSKLDKILETFAKYGAGTDKTDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIF8</accession>
    <name>A0A6A8FIF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000272">
        <property type="protein sequence ID" value="MRN69044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="371" mass="40725" checksum="E7AAD8C157B7DE1A" modified="2020-06-17" version="1">MPEIWLKYGTTDVALDIKFGNLLAQVSPDIPLMSDEDIAATLGNVAMSNNMLILPLSKSKPVQRIVQMLQAVIQSRGFEGVHVNAVRKLPIMESNEGFNVGSHDCPLFLGRRYENVIFVSRTSYDPLFGFSGTPTILLRYYMQDRMLAAFESRRSNLPTPGVDCPPMAVALSASEKLSAASVELVASNSGISGIYCGNICDGFRNAIQMLTSATTVEVDYAKSAIVAGSNEMDFSNLTASLNLLWNSVHAIQEKGSIILLAENRDGLGEGALQMFVEGKMKIEDFDKKGFYVPGLEHLLYMQNLCHQYDLGILSTLPQYYLKKLGFETYGGTKDVLQKLLAKHGKNHKILVSSAADLALLKMREQTRAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FII0</accession>
    <name>A0A6A8FII0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="11">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cyoE</name>
        <name evidence="11" type="synonym">ctaB</name>
        <name evidence="12" type="ORF">FIO04_01465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="11"/>
    <dbReference type="EMBL" id="WJXC01000047">
        <property type="protein sequence ID" value="MRN68349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN68349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="293" mass="32403" checksum="AE67E5842A9C459E" modified="2020-06-17" version="1">MRVKEYVEVSKPRIVVVLVITAVTSLLAGSRFDNTSGWHVTAWQLGFLALAGALSSMGSSALNHYYDRDIDKIMYRTSSRPIPSGRLSPRNVMAYGLGLSVLSVILAWFTLNPVATCMIALGIFFYVMVYTVWLKRYNAANIVIGGFAGSAASMAGWAAATGSINLLGFLVGWLVFMWTPSHFWCLAIKAREEYASVRLPMLPVLIGNEKTSSYIFVNTAILLPYSLALYFFGLGLLYTAVAAISGSLMLIYHYKLTKNPSPEFAWKAYKVTAPYLVVIFVALALDSLFYYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK2</accession>
    <name>A0A6A8FIK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000169">
        <property type="protein sequence ID" value="MRN68786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="192"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="357" mass="39355" checksum="20A4FE3E64260C2C" modified="2020-06-17" version="1">MRKKVRVALAGIGNCASALVQGTRYYSSATENNHGIGLTAYSLGGIQPADIEFVAAFDVTDSKVGKDLSEAIFAKPNNTVTITKVDKMDVKVTKCKVFDGVGKHLSQKLRISDKPAADVADVLRDTKTEILLNYLPVGSREATQYYAKRCLDAGVCFINAIPVFIASAPQWQNAFQNKNLPCAGDDVMSQLGATVLHKTLVKLFVDRGVKIDETYQLNMGGDMDFYNMLDDERLEDKRISKTKAVAAMAPYEIPMRVGPSDFVRFLENDKVCYISLKGKYFGNTPIELDLKLRVVDAYNSAGVMIDAVRGAKLALDRSISGPLESISAYCFKHPPVQMSYSQAKTNFLEFIEGKRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIL5</accession>
    <name>A0A6A8FIL5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000117">
        <property type="protein sequence ID" value="MRN68622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="303" mass="33620" checksum="37DF985DFF04B554" modified="2020-06-17" version="1" fragment="single">MRIPGISHLVEGGSLPNSVLLLIGPVGAGKTMYCRQFFIDGLDNGDHCIYISSTLSENQYKNLFASRIDLPEHSVFINPYLIEGQDNEKLGLALEKVNDILDSILTNRTTTNGMNNSDAVSTNNYTNRAILLIIDSLTHLFAIFGESPVINFVTQLYFLLKKIEGKAIFTLTTPSPNEYVTLSSILDGILEMKLEGDNVLTRNIRMLSIKGLHHNPSWIDFTISNDGSLIFADRSASLHCYLCQKPILDVPIMHAGFPFHDYHVETYKKLAGVYGLNISEIGISSEVVDANFFYIDIVGLSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN0</accession>
    <name>A0A6A8FIN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000040">
        <property type="protein sequence ID" value="MRN68313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="114" mass="13352" checksum="DFC2D7E7CF132D5B" modified="2020-06-17" version="1">MPLIDAFLIDFVTVDFESDSKIAKEVLYEFQKNCNYDNDDNCNFVLDSPIPSAGWYFAKLFLSSQFVKKLYELNSDQIDNSKGKKFEDKFVSWLSINFKKRKCEAYLKIASEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN9</accession>
    <name>A0A6A8FIN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000301">
        <property type="protein sequence ID" value="MRN69111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="186" mass="20005" checksum="961EFF542E0FE7BD" modified="2020-06-17" version="1" fragment="single">TVLGSFPNKKVLIGSVEEAIRLGADAVSVHINIGAKEESEMLHDLGIISDKCDEWGMPLVAMMYPRGENIKNPHDPQIVAHAARIGAEAGADLVKTVYTGDVSSFRKVIKSCPVPIVIAGGPKANTDQEIIEMCAGAMEAGASGVTFGRNIFQHRNPPAMVRALYKIIIEGKGTREAILHLDRHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ3</accession>
    <name>A0A6A8FIQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000308">
        <property type="protein sequence ID" value="MRN69121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="139" mass="15719" checksum="8E8557E6413C965B" modified="2020-06-17" version="1" fragment="single">MLTLAVLIAHLRYLPFLANLLYVGFEQVETVNDPIFALKNFKAGSYDLLIVDIVMPEMDGFSLYEGIRKIDNKVKVCFITAFEMNYQALRAVFSAATATDDIGCFIRKPVDMHDLVKRINGDTVGMYVSVSSRCLLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ6</accession>
    <name>A0A6A8FIQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000322">
        <property type="protein sequence ID" value="MRN69154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="60" mass="6914" checksum="949095F997991A1C" modified="2020-06-17" version="1">MSTQELKTVVHRFVNEFKNEGDSMASLDNLEKMAMNSTNKLDSLECYRICASEVIQREID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIR5</accession>
    <name>A0A6A8FIR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000048">
        <property type="protein sequence ID" value="MRN68353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="84" mass="9744" checksum="B7FD81FE4FD0CE61" modified="2020-06-17" version="1">MLDNDEFPNKAYKNSDNGGNMPQNDVSFNWRDIIPTLLQTLQRHLLKLSWVLEDRNKLGRELGIFDYLSMEIPERSACSSQVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS3</accession>
    <name>A0A6A8FIS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_10225</name>
        <name evidence="2" type="ORF">FIO03_05645</name>
        <name evidence="3" type="ORF">FIO04_01545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000264">
        <property type="protein sequence ID" value="MRN41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000191">
        <property type="protein sequence ID" value="MRN61519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000050">
        <property type="protein sequence ID" value="MRN68363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="131" mass="15202" checksum="81F5BD03E041F74A" modified="2020-06-17" version="1">MTSRTQEEAQKNKEKCLRILAVSPSIRYAGKMNRFGRTLGGQLRKGVVPLFKPDEARNENFLEATRNQLRRTFEHSIGKTEYTLTENEKVKILTLPNEAFFYYVTLDKDTSPEQINKIIGSLRELVKEEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV8</accession>
    <name>A0A6A8FIV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000153">
        <property type="protein sequence ID" value="MRN68738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="195" mass="21508" checksum="39D5E08A971B08E2" modified="2020-06-17" version="1" fragment="single">LVNNAGYGLNGAFEDLAMEEIKAQFETNLFGVIRVSQAVLPIMRKQKSGIIVNISSAAGRFGYPGESAYVSTKFAIEGLSESMVYELEPFGIRVVLVEPGPIRTNFADGMVATKKSQNPNSPYLEIMKKLNAVLASIRENASSPDLVAKVVLKAVTSENPSLRYLAGKDMETWMEAKRSMSDEDFRKTIKQNFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY7</accession>
    <name>A0A6A8FIY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000083">
        <property type="protein sequence ID" value="MRN68509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="64" mass="7251" checksum="61ABDB8F86B1F979" modified="2020-06-17" version="1" fragment="single">DFKEPMIMQNGSNVGDVCNKIHRSMIRDFKFAQIWGKSAKFGGQKVGTDHLLIDEDVITITKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ00</accession>
    <name>A0A6A8FJ00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FIO04_04270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000206">
        <property type="protein sequence ID" value="MRN68896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UvrA_inter" evidence="14">
        <location>
            <begin position="131"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="UvrA_DNA-bind" evidence="13">
        <location>
            <begin position="300"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MRN68896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="509" mass="57905" checksum="0EDA71C65B482D93" modified="2020-06-17" version="1" fragment="single">MHDKIIIRGAREHNLKNISLEIPKNKLVVITGLSGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLELMDKPDVDSIDGLSPAISIQQKTTSKNPRSTVGTVTEIYDYLRLLYSRIGIPHCPRCTQKITSQSADSITDSILRTAEQKKTIILAPVIQSKKGTYEKLFDELKHNGYARVRLDGELINLDDESSYDSSGHRKLSYPRLDKQKKHTIEVVIDRLIPTDDDKSRLFESVQSALKVGNGVVVASTDSEDTLYSQRNACARCGISLGDLEPRSFSFNSPFGACKECNGLGIKIEFDPELIIPDKSKSILEGAVKPWSGHFATFRSAMLRDVGKRFGFDLRTPISDMTDKQLKIIIYGTDENIQYRYESRNSDSRWEYRGRFEGVIPNLERTYKETESDSKREELMQFMREQPCEKCRGKRLRDEVLSVKIQQKSIIDICDLSIDECFNFFDKITLSETERHIARIILKEIISRLDFLRNVGLTYLTLNRMTASLSGGESQRIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ03</accession>
    <name>A0A6A8FJ03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000357">
        <property type="protein sequence ID" value="MRN69221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="304" mass="34839" checksum="5D11608528F29CE1" modified="2020-06-17" version="1">MLKRIINDASSRLFEIREKRVKPSRDDKILTAWNGLMISGFAKGFRVTNNKHYLEIAKNTIEFIESRVTRDNGRLYRTFKDGISKLNAYLDDYAFYVNALLDVFELDSNPIYLEKAIKYMDSILQHFWDPIDSSLYFTSDDHEQLIVRTKSLYDLAIPSGNSVAASDLLRLYHLTQKNDYLEKAEQIMKAGATSSAENPFGFGQLLTAIYLYVKKPIEITVRTTDNIGEGQKMARWINKQFMPNAITAIIENQSQLSRLQEYPFFSGTNSARTSQTDYAVICRNFTCSVPIYSLSGFQEQIKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ22</accession>
    <name>A0A6A8FJ22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000367">
        <property type="protein sequence ID" value="MRN69241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="155" mass="18159" checksum="C3CBA503A203BE96" modified="2020-06-17" version="1">MVSEIGFSDMLSLAQTIGIVGTMVLTLYFSKRQIQSLSIDQQTRVLNDLDEKVHKMAELVLERPSIQKVIDNQEKPSEELAFSFYVLWVCAHAYAMRQRNVLNDNEWTGWLQWMRNSFRKGTIRETWKQVEPDRWFNPAFQNFINTEIIGANLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ23</accession>
    <name>A0A6A8FJ23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000171">
        <property type="protein sequence ID" value="MRN68792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="194" mass="22110" checksum="3C143D547B15DEAB" modified="2020-06-17" version="1" fragment="single">LGLGWSKDEYQASNIPFMNRGQRADEFIQVMKKIWTDDVVEFKGKYYDIPASRIEPKPIQKPHIPIYLGGFSPNTFSRIVKYDLNGWLGVVGGPLEYTENFIKAIKEQASQANKNPDNFRIIMMTYPNVKEGVSSKNDKNRFPLSGTIDEIGSDIQRVKGMGVDHIIFGYNFLPIGRDVVKMIEISKELSKFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ31</accession>
    <name>A0A6A8FJ31_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC2_membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO02_04550</name>
        <name evidence="8" type="ORF">FIO03_03690</name>
        <name evidence="9" type="ORF">FIO04_03790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000062">
        <property type="protein sequence ID" value="MRN40295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000102">
        <property type="protein sequence ID" value="MRN61143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000174">
        <property type="protein sequence ID" value="MRN68802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN40295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN61143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="255" mass="28147" checksum="371B9A26510FD3D1" modified="2020-06-17" version="1">MITTRVKESKGFLVLKQVLLIAYLTGILWLRRNPISMVFSAISPFSLLFVLFVVSNGHYIQFAVAGSLVMALVGYGLALGQDISFYKTEYKIQDVFVASPVSPLTYMTGLALSQLLFGFPALAVLTVLAAFFGTSISNIPLLISTIFLIWGSMSAMGFFLSSHMLHMRNATQVISFVNVILAVLPPVFYSIGRLPLDLQYLAYIVPTTHASLMLQYTMGLPTPKEWSIALGLLVQVSYLIGFVMLAKTKAIWREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ36</accession>
    <name>A0A6A8FJ36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000022">
        <property type="protein sequence ID" value="MRN68217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="215" mass="24417" checksum="134971E4461DF094" modified="2020-06-17" version="1" fragment="single">YSVNFSLRTRESHLIGSKTLEKGQISFVEGILVKSMRHGGLLYLDELNAAEADVLLRLDEALDDRRQIILKEADGQIINAHHDWSVIATINPLSHVGTKELPPQILSRFPIRLRLEYPPEEIELEIVQRHTTVDISKINDIKRAIKLAKNLREAAAVEELYYSPSLRESIAFAKFLNAGSNARQAAEIVYANAYDQWGEVEYQKVMDMITSIFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ61</accession>
    <name>A0A6A8FJ61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000192">
        <property type="protein sequence ID" value="MRN68858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="80" mass="9333" checksum="456759FB976C4CEB" modified="2020-06-17" version="1" fragment="single">MADTDLQKILDAAIYQSKPGNQIIKETNISHTSAYRKIRWLVEEKLLIIDKIEITEDGKKSSLFRTILKSFNVKYEYNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ71</accession>
    <name>A0A6A8FJ71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplD</name>
        <name evidence="4" type="ORF">FIO04_04120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000196">
        <property type="protein sequence ID" value="MRN68868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="11768" checksum="1A8E9CB691A5CBE7" modified="2020-06-17" version="1" fragment="single">MSLNVGVLGLDGRKTDTTLLPAVFNSAYRPDVIHKVYVNLLSHGYQRQGRYPAAGEIVSAESRNTGLGMARIARARGEGFPRAGQAAGVAGVRHGRVAHPPESWKKIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ92</accession>
    <name>A0A6A8FJ92_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000535">
        <property type="protein sequence ID" value="MRN69505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="62" mass="6959" checksum="7221187A4166588B" modified="2020-06-17" version="1" fragment="single">SDIMSRLFAKFTSKSFQGTGLGLFISKKIIEAHGGKIWAENNTNQKGATFYFSLPKFSNIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ98</accession>
    <name>A0A6A8FJ98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000245">
        <property type="protein sequence ID" value="MRN68986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="211" mass="22685" checksum="25F7E2C36D123428" modified="2020-06-17" version="1" fragment="single">GIVNINMRPYYVEGSKTLAYEVAEQLNWQVPDNLIIPVGSGAMLNSICKGFEELHNLGLIDSIANLKITAAQPHGCAPIVDAFKKKSDEVIPVERPDTIAKSLAIGDPGDGLYVLRRLRQYNGIAEEATNDEIIDGILMLAKTEGVFTEPAGGVAVAVLQKMVEEGKIDKDEKVVCYITGNGLKATEAITAVLPKLSAVKPDVQTVLAMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA3</accession>
    <name>A0A6A8FJA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminodeoxychorismate/anthranilate synthase component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000115">
        <property type="protein sequence ID" value="MRN68619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="194" mass="21544" checksum="357F7DC15E3CA685" modified="2020-06-17" version="1">MRVLVVDNYDSFVYNIAQRLGELKTEPTVIRNEKVTVNSVKIMDPDAIVISPGPGHPADRRYFGVCTDIIAELGPQTPILGVCLGHQGIVHAFGGKVVNARKVRHGKTSIIQYNSGRLFDQVSNPFKATRYHSLVADKKIPPCLEVTATALDDGEIMAIRHRQYLIEGVQFHPESVLTEQGPKILLNFISMVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC6</accession>
    <name>A0A6A8FJC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000100">
        <property type="protein sequence ID" value="MRN68573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="525" mass="59742" checksum="28B7F27983526674" modified="2020-06-17" version="1">MTRGIDREDICNPHYIFNEKDGRYLFGDYSPFDENKNFINMLKDFVSVSSNIIHIHNNVARLHLVFRNYELLQNEMMTNIERFKTSTETLLDGFQKKYHEDIITAMFPTHADADLFFQSKNALMRPLANTKTEYSGYFEKYKHYIQSKILGSYKNAIILLQTWLSKDLDNLPYTLISDALNVLMISIDNEDESLYNTSRTTTLRVLSQGDIANSAAGFHSCVSYSFLIDCSAIEFWSHRRKVSDLGIDNLLIPVGFKTPMSEKFKRSFRFVSGNSSSGDSKNADNGARTEKEPEYISCDNYYLVQAKLEGENILSITLADDPTKLSNKVIRIDYGVSYFEYEDFVTNAEFYNKLISEGKLPTVVYVENEERYTLNLLQKEIQQITDISKILFLGKLVADKIRNLSDPKLATSKLTTIRVDDRNAISVNSITALPSSSLSSSSPLLVYDEELVISFLESLATGFAPLLIKLREKSPIKGELILRHEMDNRLGEEYVIRPEELYVQLSTTDVAKKVAAILGVSTDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD3</accession>
    <name>A0A6A8FJD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000221">
        <property type="protein sequence ID" value="MRN68928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="129" mass="14579" checksum="DA61F46DCCB1D51F" modified="2020-06-17" version="1">MSKTTSGTALPTGANDEQQNLPPLQEQTESKLPRNELTLIKKLPHQINEIVEQNARIERQLKGINKDIKQISQIRDNKLSESEESIKQIQSQIEQLQTHVTKIGNALDNAFANIKSEKKGKKKGKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD7</accession>
    <name>A0A6A8FJD7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000213">
        <property type="protein sequence ID" value="MRN68912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="442" mass="49414" checksum="ABB8C30851ED3ED2" modified="2020-06-17" version="1">MSGVDRENSNTRHPSKQIVILGSGFAGIEVLKNLQKKLSYKNVEITLVSKDNFILFTPMLPEVASGMIETRHVVTTVRSFCKHANFYEANVESIDLDGKQIVITHTIGRQSQPSDWREHTLKYDYLVIALGSENNFFGISEIEANAFTMKNIDDAIILRNHMINILEQANLEQDNHDLRKSLLTFVVVGGGFSGVETVGAVNDFVRESIKQYYPNIYMSDVRVILVSATDKILEQIDEGLGKFALEKLKEGGVEFIMNTQVKGATKNKAILHDDTVISCYSLIWTAGVTPNKLIANLQCEHDKGHRIIANDYLEVPAHDGVYALGDCASITDPHTGKPYPPTAQHAIRQGKVAAKNIVSAIKGKREGKKKKFDYKTKGMMAEIGKRTGVAILFGRIRLHGFLAWWLWRSYYLANLPTAKKKLKVMGDWTSDLLFKPDVSQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG3</accession>
    <name>A0A6A8FJG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000476">
        <property type="protein sequence ID" value="MRN69414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="146" mass="14394" checksum="F7E12F762B84037E" modified="2020-06-17" version="1">MNTKTKAFTIFVIVAAGLALITASSFSIDSVLAVKTSSSHKSKSSSGTSTSSSSKELKNLIACETTSAKGAGGLSQNQVLNCYSQAFAGNTTATTTNSTVPTFATGGNSSSTNNVGVGAGSTSGSGSSQSSSSSHSHHHSSGSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG4</accession>
    <name>A0A6A8FJG4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetolactate synthase small subunit</fullName>
            <shortName evidence="6">AHAS</shortName>
            <shortName evidence="6">ALS</shortName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvN</name>
        <name evidence="8" type="ORF">FIO02_02060</name>
        <name evidence="9" type="ORF">FIO03_01400</name>
        <name evidence="10" type="ORF">FIO04_02825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum02</strain>
            <strain evidence="9">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="WJXE01000019">
        <property type="protein sequence ID" value="MRN39815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000026">
        <property type="protein sequence ID" value="MRN60698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000114">
        <property type="protein sequence ID" value="MRN68613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN39815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN60698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="157" mass="17506" checksum="C2CEE60E4DBB538C" modified="2020-06-17" version="1">MSALLENKPGVLFRVTNLFRARNFNIESITVGSTEQPDLSRMTITLNSDERTLDQLAKQLRKLIDVVEVKVLDTDKTVYRELALIKMNAGDPTTRMEITNFASIFRANILDIGKETITVELTGTPDKIEAFKNLVDHFGITQLARTGVSALPRGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJI5</accession>
    <name>A0A6A8FJI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000240">
        <property type="protein sequence ID" value="MRN68978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="332" mass="37403" checksum="687E81D59DEAAA46" modified="2020-06-17" version="1">MSLHDIERVSITLLMDNITDRLLTSSAHAERPPMVEEEKFLPPPIAEHGFSAVVEIHYHDHKMKKKISNRFLFDTGVSENGIIFNADLLGVDLTNIEAIILSHGHLDHFAGLLSVMKRISRPLKVVAHPDAFLKRWLIFPDGTKAKMPVLDEIELKSHGALIEKRRNASYLPLDNHASDDKCNDYRHRLLVTGQIPRMTSFEKGFPLQYLEIPERNELVPDPLVNDDQAIIVNIKEKGLVIITGCAHAGLINTIKYAKDITGINKIYAIIGGFHLTGSLYEGSIEQTVQEIQSERPNYIVPCHCTGWKAVNRIIQTMPEQFLQSSVGTTFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ3</accession>
    <name>A0A6A8FJJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000238">
        <property type="protein sequence ID" value="MRN68972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="128" mass="14628" checksum="95AA32D002C68437" modified="2020-06-17" version="1" fragment="single">MGMFLPEDISQRITLFIGGKLEFPFIKKEELMGTFFIFGKNNGLYAEEEILAATDLGKRTVAHLTKTVRMFHNSPNKMDSNFTRENYTNRVLQISIELRDNTTNSPFSLSQMNKRIAGDPNILIDCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJK1</accession>
    <name>A0A6A8FJK1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ORF">FIO04_00750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000021">
        <property type="protein sequence ID" value="MRN68210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="495" mass="54164" checksum="A7FF143A84DE456F" modified="2020-06-17" version="1">MPNHLYRLTADQVASGIKNRDFSAQEYISQILERIEKIDVKINAFVAVDKQGAAEKARSIDKRIHDGEHTGGLAGVALGIKDNICTKGLKTTCASKMLEGYVPPYDATVIKKLKENDAIIVGKLNLDEFAMGSTTEYSKYGPTRNPWNINYVAGGSSGGSAASVAALECAMSLGSDTGGSVRCPASFCSVVGLKPTYGCVSRSGLISYSNSLEQIGPVGKTVSDVVMLMNAIAGTDENDQTTRATAIETTPNTISLDRIPKYSLHKNNRNIRVGLVKELVEGADPAVSKCIYSAVDLFSRSDCKCEDTSMKSIEYALASYYTIAMAEASSNLARYDNIRYGFDSNPEEYEWNTYFAKVRNNFGEEVKRRIIIGSYVLSAGYYGKYYLKAQKAREMIKQEVKSLFEKYDVLIAPTMPILPFKFGEKIDDPLKMYQIDIDTVVANLAGIPAISIPVGFSDCLPVGLQIMANEMEEQTLFDVASSFESIVDIHKSPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL3</accession>
    <name>A0A6A8FJL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_03075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000129">
        <property type="protein sequence ID" value="MRN68663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="261" mass="29401" checksum="D7E38129C6CEE65C" modified="2020-06-17" version="1">MTKLELRNVTKGFEGNNGASSVTALENINLNIEEGQFVCFVGPSGCGKTTLLNILAGLDKPTSGEVILNGQPVRETGPDRIMVFQENALFPWLKVIDNVEFGLKMAGIEKEKRHEIAMHFLDMMQLKKFAEAFTYQLSGGMKQRVAIARALVTDPEVLLMDEPFAALDSQTRDLLMVELQLIWARTRKTIVFVTHNIAESVCLGDKVVIFTSRPGKVKKEIAVEYRRPRLSEDNNLYNYRRKILDELATEIITARRIDDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN7</accession>
    <name>A0A6A8FJN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000315">
        <property type="protein sequence ID" value="MRN69136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="60" mass="7217" checksum="C746821F9FD96F7A" modified="2020-06-17" version="1" fragment="single">TRIMYRAFLSSSQLKQYIPILLDNGLLATNEERSIYNITENGMRLLRLYYQLTEMMNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP0</accession>
    <name>A0A6A8FJP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylaminoadipate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000526">
        <property type="protein sequence ID" value="MRN69494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="173" mass="18517" checksum="072F55DF38B675A0" modified="2020-06-17" version="1" fragment="single">IKAAGISGIDGGVLKADRKKKLVIINDKGRKMMIDGGYTGKINSVDPSLITLLLEKEYLPVISPVALSEEYDFLNVDGDRAAAYVAGALKANKVIFMTNVNGLRLDDRLVTHITVEQAKAALPRIGFGMEKKVLAAIEALQMGVNEAVIASGQTQKPLSKAIAHDNCTVITQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP1</accession>
    <name>A0A6A8FJP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000500">
        <property type="protein sequence ID" value="MRN69451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="172" mass="18758" checksum="697EF52A0B76F517" modified="2020-06-17" version="1">MDNIVTSGGVGPGVRAGNFTITYIELFNPTDYRVVLPSTASLSISVNQIRLEELHHTNGSIRLNQTTQPPTVNQTTIKNTPNQLTRIGVSPSIAFVYNAWNPYLKQKTYLPIAPLLNETILSNSQCAIHAIWQSSKVEQSDLAELKEYSIVTSKNSGNAPMLLHLCGGAPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS2</accession>
    <name>A0A6A8FJS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-guanine transglycosylase</fullName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000033">
        <property type="protein sequence ID" value="MRN68280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TGT" evidence="1">
        <location>
            <begin position="13"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="277" mass="30472" checksum="8A9D386650994BA9" modified="2020-06-17" version="1" fragment="single">MLSFEVRYSDLAGRIGKLETAHGILETPAFIPVVHPVRQTISPQFLKNLGFNGLITNAYTTLKYYGDDARTRGIHDILNYDGVIMTDSGGYQILEYGAIKAEPGVISQFERDIGSDISVPLDKPTGYGLKYQKAKDHVEETLANAKDTLEGRNVGRKDSEQGYDNHNNTIWVGPVQGGEHLDLVRYCANALDKMGFPVLAIGSPVEVMEAYEFSILAQMIAAVKRTVPTKPIHLFGAGHPLTIPLAVSLGCDMFDSASYMLYAKDDRYMHANGTLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU2</accession>
    <name>A0A6A8FJU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000292">
        <property type="protein sequence ID" value="MRN69088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="151" mass="15966" checksum="299AE8D12940345F" modified="2020-06-17" version="1">MTNLAFGQIFPKTPLSKSGSNPHSTLTLQHQTKPNMVKITSPTKGQQLPVKKDLVISGTSAGNSNPTSINCQVFVIVNGIKPYQQSTPIGPNGAGDYSKWIFSLTPKYTAIKEGQNKLTAKFSCANGPTTFHNSLNVTGVTATANATTAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU8</accession>
    <name>A0A6A8FJU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS5 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000296">
        <property type="protein sequence ID" value="MRN69098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="209" mass="24311" checksum="EF92B0AB524594AB" modified="2020-06-17" version="1" fragment="single">MPANKSWHDYNESLVERGRVLIDVSFLKSANDEIKKMNKGKVGAPFQYPYGYIEFVAFLKVGFKIPYRTVQGIVRGLSEYLRIEEMHFTHIRRRILKIKPSVRNLGFEGEEDDKPITLIVDASGLTISKKGDYIEEKWIREKKEFVKLHIAVDEKSKKVVSFRITKGNVHDTKKFGPLVKESAKRHDVDKVYGDKAYDNRKNFNILDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV0</accession>
    <name>A0A6A8FJV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Precorrin-8X methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_07630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000576">
        <property type="protein sequence ID" value="MRN69554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="4">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="48" mass="5647" checksum="9182446DF2843DA4" modified="2020-06-17" version="1" fragment="single">MAESAFDIEKKSFEIIDSEIGDHDYNRLEWDIVRRVIHATADFDFVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJZ0</accession>
    <name>A0A6A8FJZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03860</name>
        <name evidence="2" type="ORF">FIO04_07515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000109">
        <property type="protein sequence ID" value="MRN61176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000557">
        <property type="protein sequence ID" value="MRN69531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="99" mass="11791" checksum="8C16F2649FB7F4CA" modified="2020-06-17" version="1">MSYKVRVLSESIKFYLPRTEGYLEIIRRIAQQYAAMSLIEFDGYFEGKFEPTKYMRVEVHVNDVKEDSLIEFANKIRIMLKQKSLAFEFNNRLILVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJZ1</accession>
    <name>A0A6A8FJZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000188">
        <property type="protein sequence ID" value="MRN68849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="82" mass="9198" checksum="D76CB4076C9E1EBF" modified="2020-06-17" version="1">MSSEHFVNDSVLSLKDASEPVHILLVGPPAKTLFLRSILGLQRMLVQGLTISKIHNMFAKFSDLRMEIVPHIEGELMLETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJZ3</accession>
    <name>A0A6A8FJZ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="10" type="ORF">FIO02_03490</name>
        <name evidence="11" type="ORF">FIO03_00500</name>
        <name evidence="12" type="ORF">FIO04_05465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum02</strain>
            <strain evidence="11">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000041">
        <property type="protein sequence ID" value="MRN40093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000008">
        <property type="protein sequence ID" value="MRN60522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000312">
        <property type="protein sequence ID" value="MRN69132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN40093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN60522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN69132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="132" mass="15119" checksum="ECEE81A340C61C8C" modified="2020-06-17" version="1">MSEQELPPWLKEQLSRLQQLQQNLQAIMMQKQQVEIEIVETDRALEELKKIGTEDIVYKSAGPLLIKSKKEDLLKELGEKKELSNTRVMVLTKQETRVKDNLKEVENKINQMIRGTQGTAGATESSSKPRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK31</accession>
    <name>A0A6A8FK31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_09845</name>
        <name evidence="3" type="ORF">FIO04_03995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000244">
        <property type="protein sequence ID" value="MRN41327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000186">
        <property type="protein sequence ID" value="MRN68843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="167" mass="19607" checksum="70B13202E18510DF" modified="2020-06-17" version="1">MELQGEFKLRADSRTKSGTDKTKSKLLKRINNSPGIRYRELLRATGFSNGVMAYHLKKLENSKRIKVSRSHRRSTRFYPLSIAARELRVIEFIRRRTARQIVRFLLQDDSRTFKDIVQFTKKVRSTVSWHLSRLREGGIISVGVGRNQTYRLKNRDLVIKVMKKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK65</accession>
    <name>A0A6A8FK65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sufD</name>
        <name evidence="2" type="ORF">FIO04_02745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000108">
        <property type="protein sequence ID" value="MRN68597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="475" mass="53674" checksum="5964927E6702AB99" modified="2020-06-17" version="1">MNESVILSSINSDYINTITEENREPTWLSEIRREAFSKYTALPAEVSPLYSKYSDVNRLRAESVRLSDQTTRFQPYEELRERLKEPEQGASVLRIGSSINNMVIPEKISQMGVIILDLKEAVIKHEDLIRGQLTSNRLNYSEDKFLALEVSAFNSGLFIYIPKNVVLEDPIRIINSLADDGSSSIARAIIIADVGSKATVVEEIYAPQMERNETVQQAYFELIESHVGPNAHLEMVTLQAMSRNTINFSNRKAFIERDGKMSWYLGMFGAEMSRYKVDSIMKGVGASAEDVEIIFGIGNQSFDVTSNLIHYGRNSRGRVLVKSVMKDTSKSLFKGMIKIGKDAKASESYLAGHAILLDKGAKSDAIPGLEIETNEVKATHSASVAQMDENQIFYLMSRGLNREGAKREIVSGFLEPLSRKMGPAIRAWINYLIENKWAGKSLMLKTDEAMEQILEVEKSRYRETQDIFEKHYKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK70</accession>
    <name>A0A6A8FK70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_08310</name>
        <name evidence="2" type="ORF">FIO04_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000175">
        <property type="protein sequence ID" value="MRN41028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000216">
        <property type="protein sequence ID" value="MRN68919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="76" mass="9043" checksum="08BF9716B4DC29FD" modified="2020-06-17" version="1">MSKSQEEMHVWRKKIEMIGIDIKHLDQDMDTNRFRLKTRIMNRHFINELNKIGLQLINMTGTFDGKLLVLLETKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKD3</accession>
    <name>A0A6A8FKD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000127">
        <property type="protein sequence ID" value="MRN68657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="167" mass="18853" checksum="508F9384CEAB4936" modified="2020-06-17" version="1">MKTPICSFDAKTGVLCAGCEAKLEAGQLTPTEIEIAIKLTRLAEREQEVNTLSMISAAKSGVDSVLFLRGSDISFLRSNPELLRKVEVEFGGAVWFVEAQATDRRFMENLFFPSKVLNMNFFWLPDGKKLTRVLIDRKDPKNAIKTRRIQEIAKELRNVELIIEYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKG0</accession>
    <name>A0A6A8FKG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000411">
        <property type="protein sequence ID" value="MRN69318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044065">
        <property type="entry name" value="ACP_MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51901">
        <property type="entry name" value="ACP_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ACP-type MB" evidence="3">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="209" mass="22860" checksum="1315EC41DBB545AA" modified="2020-06-17" version="1">MSKVIKARNEFTVVVKKELARQHRDANMTTRVLVRDIMNSPVVSAALTDTVNEVALKMKDQKVGSIIIMEGENPVGIVSDWDIVSNAVVKDVQPSTIRVSDIMQKLHSIEGEEGVTEAARMLRQHNIKRLGVVYKNRLVGIISASDVIAVTPELVDVISEKAAIVRGETGRSAGSVSGYCDECGEWSDLLQFADGTFTCEECRGEEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKH0</accession>
    <name>A0A6A8FKH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000416">
        <property type="protein sequence ID" value="MRN69328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="122" mass="14156" checksum="2901BD4F462D08DB" modified="2020-06-17" version="1">MDLTLKGMAGKRGLMFVSYYGRSRAFISNYRTWQQYHNYGKIVEIASSLLSHESLHLTLNKFSLSASAKLDNLFGRSNTWENYPHGLGDFDRIRHANPTSYKNAQKITKIKAHRRRRIKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKL6</accession>
    <name>A0A6A8FKL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000452">
        <property type="protein sequence ID" value="MRN69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="254" mass="28285" checksum="936A6C6DF48F0A21" modified="2020-06-17" version="1" fragment="single">GIDKFLFSGIMRKKGVKLVRCNTVDLEVPANAEIVLEGYVDPDDIRMEGPFGDHTGYYTPSEPFPTFTLTGLTKRKDPIYLTTVVGKPVLEDAYIGKVIERSFLPLIQIFQPEVVDFAMPAAGWFQGLAVISIKKRYPGQAKKVMMGLWGMGQLSLTKIFVVVDPDINVHSVDEVIWAITTRSDPKRDTMVIDNAPTDTLDPASPLVNLGSKLGIDATTKWKEEGYAREIQQLAVVDDETKAVVDRNWKKYGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKN8</accession>
    <name>A0A6A8FKN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000112">
        <property type="protein sequence ID" value="MRN68610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="106"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="401" mass="43990" checksum="C6037E2B847F5964" modified="2020-06-17" version="1">MSNLERNANFLTLFGIVVITIAMILIIGSSSFPNMALSKSSSHNNNKPSSHVPLLSNGGISGNSGIGASNLNGIHNQSSSTSLYSAPPPSASTLGGNISKGVSSNKVVMIGFDDGWKSQITYAKPILDKYGLKASFFVVCNYVNSGDIRRMNWQDIATLQQDRMDVQSHTMDHKPLDKMSTNALIYEIAGSKQCLASHGIDSTIFGYPFNLGSNMPSVVDIVSKYYNFARTGTYPLMSLNCNGFANIKPQQTDCRTYLPDGKLTFANRYDIRSDSFFHISSGHNYGPSEMFQKFIQQVNSQVPYNNNGKINAIPIITYHDLTYNIQDYNKAGTTITVPLFDQEMQYLHDNGFKVLLLNQFGFDPTNNVFYLKKVPSSTHGTTTNAATLLSGAPSYSTSKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKQ7</accession>
    <name>A0A6A8FKQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000521">
        <property type="protein sequence ID" value="MRN69486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="126" mass="14201" checksum="363A6E45C3E77D89" modified="2020-06-17" version="1">MNWEDIALMQKDGMDIQAHTATHPLINRLSANALNVEIGGSKQCLLIHGYHPTTFAYPYDEGADNKTIVNLISNYYDIVRSGSERLMFLNCNGFKTQPQTDCKTYLPDGSLTYANRYAVRSFTENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKR7</accession>
    <name>A0A6A8FKR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000163">
        <property type="protein sequence ID" value="MRN68767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="158" mass="18603" checksum="EEA8444AC4F23CE2" modified="2020-06-17" version="1">MNNNRTHDSWLTEHHLLKGAEEFFRLNEYSNIEYDKEFDKGSRSFSSAISAYKKAEETGNDEFDQILVGVVRPKINNYDLQFFGYLESILYDVMDNYEYTKLMLITDSLSYLPIINRDDVSVAIENMMKDGLNVLFLNHRFSYAFFERFGDMTKPILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKS3</accession>
    <name>A0A6A8FKS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_06905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000475">
        <property type="protein sequence ID" value="MRN69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="296" mass="32186" checksum="448961CA07E9BE80" modified="2020-06-17" version="1">MVRSSKKAVYAALFGNLGIAIAKLIAAILTGSTAMFAETLHSISDTFNQVLLLFGIKTSTKAATEQHPFGYGKEQFFWSFVVATMLFGISGILSLQQGFGSLLSRIHHIQNADVSYVILAISAAFEANALRVALLLAKESIEARGDKISLNTLVQEFQESKDPSVITVMVEDSAALLGIVVAGIGIFFSEATGDTIYDSLSSVAIGGILMAFAYFLAKENKALLIGESISRKDYNKVVKLVNEIPDVNRIITMRTMHFAPEDVLVTIEVNLVDGLDTDKIESVIDNIEQKVKLMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKV3</accession>
    <name>A0A6A8FKV3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="6 10">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FIO04_07190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the aTrm56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="6 10"/>
    <dbReference type="EMBL" id="WJXC01000509">
        <property type="protein sequence ID" value="MRN69468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
        <property type="entry name" value="UCP016123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="110"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN69468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="176" mass="20042" checksum="D76566F11E1B634C" modified="2020-06-17" version="1">MKVSVLRIGHRLVRDDRLTTHAALVSRAFGSDKIYMSEVDDSLKQTIEDVSSRWGGRSDFKVEIVGGWREVIKDWKKDGGKVVHLTMYGIHIDDAISNLRRENTILVVIGAEKVPREMYDLADYNIAIGNQPHSEVAALSIFLDRMFRGKQFEKEFKDAKLKIIPTAKGKRVREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKV8</accession>
    <name>A0A6A8FKV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000175">
        <property type="protein sequence ID" value="MRN68807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="49" mass="5747" checksum="ACDB6A5CEF82A3FB" modified="2020-06-17" version="1" fragment="single">MKYRKLGKSGIKVSEIGFGAWTIALDWWTARNKKIDDDEAIRMLKRAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKX3</accession>
    <name>A0A6A8FKX3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfe</name>
        <name evidence="6" type="ORF">FIO04_03210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000137">
        <property type="protein sequence ID" value="MRN68690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="173" mass="19973" checksum="4D81CBF4DF7B85DA" modified="2020-06-17" version="1">MPSAEYEDSFVKIAGLIGGEEYLKVARGLLNTDDATDEEIASATGLRINIIRKVLYDMFGKALITGIRVKDEKKGWFVYRWRAKKDQVDSFIDNQKKKILERLQIRLEYEESSEFYHCGNKDCPRVKFDSAVELFFKCTNCKGPLNMVDNGRVKEALRYKIEQLTADISSRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL29</accession>
    <name>A0A6A8FL29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_06625</name>
        <name evidence="2" type="ORF">FIO04_04165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000113">
        <property type="protein sequence ID" value="MRN40700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000200">
        <property type="protein sequence ID" value="MRN68877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="74" mass="9026" checksum="17A476BF9E2816EA" modified="2020-06-17" version="1">MHPHGKLGDLWEKYLQAEAEFHFQELSAVTSELISGRTMYCPKHEDMFIKLLRKDMSWFMMDMIWFNDKEEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL60</accession>
    <name>A0A6A8FL60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000211">
        <property type="protein sequence ID" value="MRN68907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="459" mass="53130" checksum="1BA0E4B624B2EE19" modified="2020-06-17" version="1">MTTASSIGYPPGPHSILPNKLLRGFMHDPIKTLVDIARTYGDICHFKFGRQHIYLLNNPHYIEDVLIRNYKNFIKSRGLQVSKRLLGEGLVTSEGEYHDRQRRLIQPTFHPNRIKGYGNIMTSYAVRMCQRWEDGITLDIHKEMMHVTLEIISKAVLGSDVKPEDDEVGIALQTCMEYFNRLQMPFGELIEKIPILPINKGYQIAKKKLDSIVYSMIKEHRDKESKGLYHEEDLLYTLLQAQDTEAGIGRMTDSQLKDEVMTIFLAGHETTSNALTWTFYLLSQHPTAEARLYAELCSVLGDKDAKRIPTVEDIPKLEYTEKIFREAMRLYPPAWTIGRQAITDYKVDKYVIPAGSIILMSQYVMHHDSRYFSDPDLFYPDRWTKEAKLQLPRFSYFPFGGGIRGCVGEPFAWMEGILLIATLCQQWKMHHDPDHKVGLKPLITLRPKYGMRMNLEHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL83</accession>
    <name>A0A6A8FL83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_03830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000176">
        <property type="protein sequence ID" value="MRN68810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="421" mass="46620" checksum="9E1AB10F7557A5B2" modified="2020-06-17" version="1">MHLNEFVAIGVFVIVFFLIVERRRLNNIPIWTSMLIGAALMIGLQVISLEDAFKAINLDVIIFLFGMFSIVSALDRSGVLKFVAVKMLSKAGNDLNSILLVFVIGFGIISAFLVNDTIALLGIPLIVHISRQISIRPTVLFIALAFGISIGSVMTPIGNPQNLLIAIKSNIPLPFLTFLRWLFIPTIVNLFLTYFILKVYFKEELSKVPAKISVIILLFTVAGFVISEVLQFLFHVVYFSISVIAVLGATALYAFSRERRELMYNVNYSVLVFFAAMFVFTSALWTSGLIPEIMMHIPNPVANNNNNDNVIRNNAIISVVSVTLSQILSNVPFIVLYNNVMINNGFNADDVSQWMMLAAASTIAGNLTIFGAASNIIIIEAAESRGVKAFSFFEFLKIGSMVTASNLIIYYLFTTFLFGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLH7</accession>
    <name>A0A6A8FLH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000454">
        <property type="protein sequence ID" value="MRN69383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="44" mass="4765" checksum="382B3D112A986727" modified="2020-06-17" version="1" fragment="single">MKSITCRFGNLIANQNVDFDLTRGEIHALLGENGAGKTTLMSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLI2</accession>
    <name>A0A6A8FLI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000452">
        <property type="protein sequence ID" value="MRN69379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="83" mass="9201" checksum="BC7EB2D65E8BE38B" modified="2020-06-17" version="1">MPTAYVLINCDISHKTEVIKELSQLPGIFEVAEVHGAYDILVKLNQGSVDELKETIKWHLKKIPEIKSTVTLIAIESTDPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLI4</accession>
    <name>A0A6A8FLI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_04345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000212">
        <property type="protein sequence ID" value="MRN68910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="282" mass="29137" checksum="1DADB60808E5DD66" modified="2020-06-17" version="1" fragment="single">MKVITLQRRSINFKSSIPFLSAGLAFVVGAIILYAAGVDPINAYQIMLKGAFGSIRGIGDTLVKTTSLLLVGLAVAVAFKCRIWNIGAEGQLYMGALGAALIGITAIGAIPGLALIAVIAVGFAFGGSFGLIPAALKVKFGVNEIIVTVLLNFVVLLFISYLLHGPIKAPGFNPYTPEIFPASRLPIIIPHTHLHAGIIIAAVAAIAVYILLWKTKIGFEIRSVGANIKAARYAGMNVAKSAFVVMGVSGGLAGVAGAILVSGVQLQLLEGISPGYGFIGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLP3</accession>
    <name>A0A6A8FLP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000305">
        <property type="protein sequence ID" value="MRN69117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="37"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="435" mass="48462" checksum="0865ADE5727B5961" modified="2020-06-17" version="1">MDYEALRGDGGTDKIDPYDIIESDSIRRDFPVTHRKVYMNNGAIAPTPLSTIKSITDFLVKSSEGGPGSTFISEYITSLMKELRTRITHLINCEPEDVIFTQSTTEGLNYVSSGINWSRKTNDSIIVRGGTHEHYANYLPWLQVSKRKGIKLHELKIDENGYFELEELEALLKKTNNGNHNNKSNRGSTTLITLSHALYNNGSIMPVTDVGKIARENQALFCIDAAQTVGSICVDVKKIGCDFMAFPAFKWICGPVGMGIFYCSKKAAEFLVPHFIGGESATLSVDEKQKQKKVITYADGPERFQAGFRNYGGVAGMESSVRYILRLGIENIRKKNLKIANVLRDELAKIPNIKIHGPDDENLRTSIVSFSPVSSSSTYSIVDSRTIVNKLEQNEIIFAERDIGGGMKAVRAAPHFFNTEEEAVRAARYLKDILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLQ9</accession>
    <name>A0A6A8FLQ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UVRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000498">
        <property type="protein sequence ID" value="MRN69449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVRC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="100" mass="11160" checksum="62592CA8C1DEA8C6" modified="2020-06-17" version="1" fragment="single">AQPLPDLIVIDGGKGQLHCAIDALHKIGLEVPCISLAKENEEIYSPDSTHPVLLSRNSPALKVIQYIRDEAHRFGLAYNRNLRRIKTNHKNISSPNLIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLW4</accession>
    <name>A0A6A8FLW4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000551">
        <property type="protein sequence ID" value="MRN69523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="69" mass="7761" checksum="0E66EA9C83AAE833" modified="2020-06-17" version="1">MRALSNDECSVCGSDQIVTIPDSGEIVCENCGAVISDKYRKKVQNGLVLPQRQQEEKKTTKIEQECLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMG9</accession>
    <name>A0A6A8FMG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="7" type="ORF">FIO04_06010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000366">
        <property type="protein sequence ID" value="MRN69240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="299" mass="33115" checksum="0A8C80FF4347012E" modified="2020-06-17" version="1">MQTSIVCSVCNKNNETVTDPDSGELICGNCGTVLLENIEESGPEWRLLGEGKDRSRTGMPTSLSRHDMGLATIIGKTNRDASGRGLDASVKSTMERLRTWDLRIQTYSPSDRNLRQAFSILERVKDKLGLSEPVIEKTAYIYRKAQERGLVRGRTITSVLSAAIYIACREMGIARTLNDIASLTNLRRKELARTFRLLILELDLKVPVVDPMKCIAKVANKTKLSERTKRQAMDIMTSVTKRGISAGKDPMGLAGTVLYMSSKNSGETITQMDIANAAGVTEVTIRNRFRDLKSKIDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMI9</accession>
    <name>A0A6A8FMI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000378">
        <property type="protein sequence ID" value="MRN69260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="130" mass="14818" checksum="D5CE6ECE412D42B1" modified="2020-06-17" version="1">MNKYIEQDLQKQQKQQPQQIPVGMITERDVVNRIAIDPSNVNVSVRELISKPLITIFENSSLMDVIHSMQSKNIRRLVVTDYSSNKKLVGILTDKDIFRTLAKNRDLVSGLSGTATTTEILEKYRTVFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMP1</accession>
    <name>A0A6A8FMP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000522">
        <property type="protein sequence ID" value="MRN69487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="332" mass="37267" checksum="9E2588177B2F712F" modified="2020-06-17" version="1" fragment="single">MKGPVRKRNVSNLNHNHKDRQRIQEQILTLNENDSIEQLLAQKFKKEGFESLTTIQQKALPIIVRRINCLLVAPTGAGKTEAAVMPVVTMLSISARLSGKIRAIYITPLRALNNDVFRRIVRYAESENLRVQIRHGDTTTKEKKKIVESPPDILITTPESLGVVLSSQRMLLALQNLEWIIIDEVHELIANERGAHLSIGLERLQAASLERVTRIGLSATVGNLAEAGKFVSGTNRKHAVLVDRSGREYDIRLEYIQGSFTNVAHFIIEYIVSNKISGSVLLFTNTRDEAEYLATVLKNQSEVKVDVHHGSLSREMRQETEQRLRVGDAGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFG2</accession>
    <name>A0A6A8FFG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homoaconitate hydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_03780</name>
        <name evidence="6" type="ORF">FIO03_00400</name>
        <name evidence="7" type="ORF">FIO04_00215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000046">
        <property type="protein sequence ID" value="MRN40146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000006">
        <property type="protein sequence ID" value="MRN60503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000004">
        <property type="protein sequence ID" value="MRN68105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN40146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN60503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="455" mass="49638" checksum="C84B34695169DAEB" modified="2020-06-17" version="1">MQTTSSSLQRQEKQDVSHIKNILDNKSLTFAEKVISIKNVETRNKRSQIISMAGDIVIVDVDLAMAQDSTGPLAIRSLNEMGIDKLHDPSKALLVIDHTFPAADEKVANLHALIRDFVSKHNCMKIEGSISHQHILEYLATPGMMILGADSHTCQAGCVSAFATGIGSTEIAAVWATGQLWLRVPETIKINLSGTFNKGVFARDLILDYIGKVGEDGANYKALEWKFSNDYVKRQFSMDSRACISNASMECGAKISVFPTDEITTKYLDENPRINNNMGGKIEIQPGTSAKYKDEFEIECDKIEPQVSGPDNIDKVHSIEELANVEIDQAFIGSSTNGRIEDLEIAAHMLKGRKVHKNTRCVVTPASVKVYEDAIRRGYVEIYLESGAVFTNATCGACVGTHLGALGENEICISSSSRNFVGRMGALSSKVYLASPATVAASAIEGKIADPRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFN2</accession>
    <name>A0A6A8FFN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxy-3-methylglutaryl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_00670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000019">
        <property type="protein sequence ID" value="MRN68195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="180"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="465" mass="52453" checksum="C7B374C36FB4BCC0" modified="2020-06-17" version="1">MPVGIDDLAIYIPKLYIDYRDFAEARGIDPRKLEYGIGVKKMALVDTNQDPACMAANACLKLMQKNHLHPEDIGRMYVATESGLDESKAMNSFVIGMLEQVYGESSFEHAGGIECKFACVSGSYALYDNTNWIRADENNGKAAIVIVSDIAKYDIGSAGEYTQGAGAVAMLIKENPRLLAFDQKVTSTIISNEYDFYRPCGKDTPVVNGTYSSLLYLIQVRKAFDSYKEKAIRTGLIRLKDGESITDHIDLFSVHLPYRRMGEKALAYLLRHEWRDLPRWNKVVKEVGLQETVPKDPRGTIESILADTEFMKADERFRRAFMQTSFYNEVFEKKMASSLEASTIIGNLYTASMYMGFRSLLEFEYKKGTDLESKRVGFGSYGSGSSAMVFTGVIQSEYKEIVEGMNLEEEIGPRKKISIHEYERLRGNERNFDTSLLPVHNEFVLVKIGGTTADKAGFREYNFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG23</accession>
    <name>A0A6A8FG23_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 6">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dph2</name>
        <name evidence="7" type="ORF">FIO04_00615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="WJXC01000017">
        <property type="protein sequence ID" value="MRN68184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="334" mass="37651" checksum="C6F4621D2E1EDA89" modified="2020-06-17" version="1">MMLIDEKRIHEVIDSRKPHSVALNGPEGLIPRIQTSAANITEKFGIPAYIIGDTCWGSCDLNTQAADILGVEILFNIGHTIANETFGERVIMINAYDDISFDRVARKCASSLQNENYKTLSLLTDSQHLNQIGNVKEIFEEYGYKVIIGKGKGQLNDGQVFGCEFYPAFDIQNLVDAYIFLGQSRFHSVSVAMSTEKPTYMLDPYFEEYSQINKIAQMFKKKAILSIYKAMDARGIGIIIGLKEGQFAKIQALKLKKLFEQLGKRVQLIAMTNITNDHVQIFKGLDAFVEVACPRIAIDDHFDKPMLSTPQAFALIKLLKNEPIEDLLKIHHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGC0</accession>
    <name>A0A6A8FGC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000039">
        <property type="protein sequence ID" value="MRN68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="80" mass="8726" checksum="D9EA677068B3267B" modified="2020-06-17" version="1">MTTTSNGNGQLFEKPEYTDQKLLACIWSILNLHFSLDTIFINCVAASSLSKMPDANGEEYIVDSSQLQVNVLSAAAVMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGF8</accession>
    <name>A0A6A8FGF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Double-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000040">
        <property type="protein sequence ID" value="MRN68314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15689" checksum="ABDA9A779F92F4E6" modified="2020-06-17" version="1">MSEEEDRDLTIIKARKMKELQKQAATQEKMKARKEQESQPRTDVEIISSYMYDRGEEVLDLAKSQFPIQTRAIVRKIVELIKAGEINQRISGGELLALFRSVGMNIRVNTSIRVEDHGKLVSFSDKLKYENEDSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGI8</accession>
    <name>A0A6A8FGI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000003">
        <property type="protein sequence ID" value="MRN68096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="157" mass="17296" checksum="0B5771582B8F5B1A" modified="2020-06-17" version="1">MTLTITDILRKKLESIEETTTIQEAAKKMKDKNVSSLIIIDMSGKPVGLVTERDLVRKVCINDVPTSTVTSKEIMSFPLITIKATSSPSAAADMMLKNNVRHLLVVDEGSANKPIGIITPLDFTRYQEYTADEDKEAIEKVLENYMSSPDADAFTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGV7</accession>
    <name>A0A6A8FGV7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000073">
        <property type="protein sequence ID" value="MRN68474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="84" mass="9731" checksum="DCF3EFBDBF9DE96B" modified="2020-06-17" version="1">MNGLDPYREIKKVDARVKACFLTALSDLQEYEDLKKKVFQEGEGYSIVKPIDNEELLKRVNEMITVNDQNEVPLVAWSNTWPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGX0</accession>
    <name>A0A6A8FGX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylyltransferase/cytidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000081">
        <property type="protein sequence ID" value="MRN68501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="195" mass="21900" checksum="FDD794B4762DD7DE" modified="2020-06-17" version="1">MSSLDPSVASLDRLRSRLPLPREIYNEKIQKLVDLGFVEKSDMPKLTFLGRDAFKVVLVGGVFDLIHPGHIHTLKAAKAQGDVLIVVIARISTAAMIKKDRRIYHDEKLRAELVSSLRLVDLAILGREGTLYETVEHIKPDVIALGYDQAHSEKDIADNCQKRNLTVRVVRLNTPVPGTKSSEIKDYLGESFYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH27</accession>
    <name>A0A6A8FH27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000029">
        <property type="protein sequence ID" value="MRN68256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="202" mass="23442" checksum="21E86507E81195E2" modified="2020-06-17" version="1">MTNRNIIFQNFDAALDELKRKLYDGEYYNTPNSCVYVLYNIEIHGFQTFASSLCNSSSSGENGMSEYSTTIRILEIKTNLEEFDGHINKKINQNLLENLSKEEYRKLLIDYLVHLGLEKIQTNPLDVAAMHEMQSKDVKSFINKLQYTPQKVDDLPLLLVGWYRIPPAIARLIAKNIIQDKNMEIYTDNKAQKWIKLQSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH43</accession>
    <name>A0A6A8FH43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000163">
        <property type="protein sequence ID" value="MRN68765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="344"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="484" mass="53571" checksum="A1C329B0B06B41DD" modified="2020-06-17" version="1">MELNRRILFTGLVIAIILSDSIIFLATDKSRDFYSNWIININSAIAAALAIFIVFRQKFHTLHGKAHAALAIGLSLWLCAEIIWAMYEIVWQIVAPVPSVADYLWLSAYGFLAYYLFATYKEFNKKFRFSKKVLIASIIGGVIFVTYIIGLTTSLSVLSTPRSIAMFSVMIAYPTMDAILMVPAIVILLDIRKEPLWFTPWICESLGLLLIVLSDSWFTLVVLTSLTEQFWLSSLFFAAHFLVMAAGLVWYIKYLTLHHYEQQPQHQHKMTNSDTRLHNGNSNMIVPPPAVSEKRKKRIPIGTITCMVLILFAGFVVYSIYPIIFSFGNANIEVIPAPASSKHTVTLGALLSLSGASASLGESEEAGLKIALRDVNESFKRTNTNLGVGLILEDTHTNPAFGIEELKDLASKGIRIVIGPSTSAELEAIKDYANNNGIILLSPSSTAPLLATPGDNIFRLVPDDTHQAEVIATQMRKDGIEVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH51</accession>
    <name>A0A6A8FH51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000165">
        <property type="protein sequence ID" value="MRN68775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="67" mass="6523" checksum="08B31F094B36774A" modified="2020-06-17" version="1">MTYNSLAVAIAVATGIMLATSGSAASVLAQQYTTPKAGNPSGNSPMKSGNTTSTGGMMNKPAAGNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH90</accession>
    <name>A0A6A8FH90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease subunit alpha</fullName>
            <ecNumber evidence="4">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureC</name>
        <name evidence="4" type="ORF">FIO04_03855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000177">
        <property type="protein sequence ID" value="MRN68815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease_alpha" evidence="3">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="58" mass="6336" checksum="7D24B4C3254A67DC" modified="2020-06-17" version="1" fragment="single">MVLKLTRKHYTDLYGPTTGDKVRVGDSDLLIEVEKDLITPGDECVFGGGKTLRDGIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHI3</accession>
    <name>A0A6A8FHI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000140">
        <property type="protein sequence ID" value="MRN68701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="156" mass="17577" checksum="ACDE9578AA9459F0" modified="2020-06-17" version="1">MRELSTRTVIFHHFIGERLGLNPTDHKCLDIIIRATNPITAGRLADETGLTTGAITGVMDRLEQAGYVKRERDPNDRRLIFINPLLDKAMAKIGPLFAPVKLAGQKLYSKYTDQELAVILDFVINCNKMTQEMTTKIRAEVADDIKTHQPEDKSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHM5</accession>
    <name>A0A6A8FHM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000235">
        <property type="protein sequence ID" value="MRN68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="56"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="189" mass="21559" checksum="93E427AF569260F6" modified="2020-06-17" version="1">MTTIGEEDEHIIATPSYGLFLLSDSKSTNFKKDLYEEANGKYLPSLTNKSRTNTKRILIVDDEPDITLCFKMTLEDNGFKEQVDAYNDPGIALSAFSPGSYALLLLDIGMPSINGLALYEKIRKIDSKIKVLFITAFDLDYEVLKRLYPQHEDVIPTILENSEGCFIKKPIDTDDLVRRVNKEVFNYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHR3</accession>
    <name>A0A6A8FHR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_03650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000165">
        <property type="protein sequence ID" value="MRN68774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="505" mass="54473" checksum="E9360BF9BF175BAA" modified="2020-06-17" version="1">MTTIGLATIIPFLGLFALFIVLGFYGKYWRRGNLNDIHEWSLAGRKLGTTLVFFLLGADIYTAYTFVAIPSGVFAKGSLYFFAIPYVALAFGVALVTMPRLWALSKEKGYITASDFIKDRFGSKTLAVLVAITGIVSLLPYIALQIVGMQSVLIVMLSGITNSHTVQEISLLVAFVILAAFTYTSGLRGATLTAILKDILIWITVIAVIIVVPLSIGGFGTAFRDVKPSYVTVPNSLVTGYATLVLGSALALYLYPHAINGVLSSESVHKLRRSTALLPLYGIGLAIMALMGILVYAVPPAMNFLSHFPESSRGILVVPSLILYSMPPWFTGIALLGIFIGGLVPAAIMAMSQANLLTRNIIKEIRPNTSASSEIRITKISSTVFKFVALGFVFTIPATYAISLQLLGGILIIQILPAVFFGLYIKSLRKEALIPGLLVGIFSGTFMVEYTNHFGALTSSLFNIPIFGSLYIAVVALTFNLTISFGGSIIMNRKDGLALFQTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHT3</accession>
    <name>A0A6A8FHT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000047">
        <property type="protein sequence ID" value="MRN68348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="75" mass="8635" checksum="F58DB23C4DAB1934" modified="2020-06-17" version="1">MNYPLRNLIYEKIKHAGNMTDSELMNALTKDGVPITEAELDKTLLDLEIYGLVRVSWMTKDKRRIEARLVDSTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHU9</accession>
    <name>A0A6A8FHU9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO02_02395</name>
        <name evidence="10" type="ORF">FIO04_03835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="9">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000024">
        <property type="protein sequence ID" value="MRN39877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000177">
        <property type="protein sequence ID" value="MRN68811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN39877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="276" mass="29145" checksum="B7607DDC92D9FB0B" modified="2020-06-17" version="1">MVGDLKAFIAVSIPAMLLFGMRHALDVDHITAIDNLVRLHNARKKARWVGTGFSIGHMTSVLGEMLLIIYTIGSTTSGKVDQLSFWGGVIGAIALATIGAINIYSMKRWGKTGSAILASKVVARTHIFGPFGSALITGLVFGLGFDTATQISALTLTVAASATLGVQVALILAGFFALGMIPVDTLDSVVLRSAFSRIFNTKGFTYMAYALSGLALTIAAIESYSVITKTNILSPLTGPVLAVIIISGTFGYSFVTRNRAVQTPSTLADDHKEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHV3</accession>
    <name>A0A6A8FHV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_06415</name>
        <name evidence="2" type="ORF">FIO03_02920</name>
        <name evidence="3" type="ORF">FIO04_00385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000107">
        <property type="protein sequence ID" value="MRN40660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000073">
        <property type="protein sequence ID" value="MRN60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="98" mass="11531" checksum="1EA90B80EFB9C911" modified="2020-06-17" version="1">MKVRVYFCREIDPEIILKGNKISRQALDTIYDLVWECEFKNILNVGRVWLKFREEKPFGIPVKEKRSHSRIAAGDIIQIANDFYMVNQVGARQIEVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHW5</accession>
    <name>A0A6A8FHW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl44e</name>
        <name evidence="5" type="ORF">FIO02_00795</name>
        <name evidence="6" type="ORF">FIO03_02210</name>
        <name evidence="7" type="ORF">FIO04_01620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000006">
        <property type="protein sequence ID" value="MRN39572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000050">
        <property type="protein sequence ID" value="MRN60857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000052">
        <property type="protein sequence ID" value="MRN68378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN39572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN60857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="92" mass="10807" checksum="96ABCCB34B9BFD62" modified="2020-06-17" version="1">MKMQKEQNKFCSKCKTHTVQAVSIYKKGKDRATAQGARRHAEDKRGYGGQKFPELKRTAKTTKKIRLRYTCKTCQRQTMKEGIRMRKLEIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHX2</accession>
    <name>A0A6A8FHX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB</name>
        <name evidence="5" type="ORF">FIO02_03145</name>
        <name evidence="6" type="ORF">FIO04_00485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000035">
        <property type="protein sequence ID" value="MRN40025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN40025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="259" mass="29074" checksum="E7E037A44C62B771" modified="2020-06-17" version="1">MKEEQKEQAYKVSIKKLEAWFGTKQAVKDVSLDVKENTITAIIGPSGCGKTTLIRCLNRMHEMTPSSRSRGQVIIDGIDIYDRNIDPVIIKRRIGMVFQKPNPFPTMSIYDNVAAGLKLNGVKDRQLIDEIVKESLQGAGLWEEVKNELDKPGMGLSGGQQQRLCIARALAMQPEVLLMDEPTSALDPMASSKIEELVHDLKQELTIIIVTHNMQQAARVSDYTAFMYLGELVEYGPTKKIFENPEKELTERYISGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHX5</accession>
    <name>A0A6A8FHX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_00040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="721" mass="79488" checksum="B875D656FD64F211" modified="2020-06-17" version="1">MEQLSHDKYPIQAESTRDGVLESASKRVRMIFSVMASPNRIDILRILNSKGPLTYSELKSLAGFKSKKESGKFAYHLRKLLRQSLVALNKAERRYTITNLGKLVLSLARQIEERSIIESGKMYVRTTRPSIEEFNSNKIIQSLVREANMPLEQAHKITEEVENKIYKFQAVYLTSSLIRETVNSVLIEHGHEEYRNKLARLGLPASDIVEMLSNADAAKNGLETLMSKASQSIFSEYLLINTLPKDIADMHLAGEMNISNSGTWGLIPDTIFLDVTNFRENAMDLKGKFLNVSRMPLPGINNSNDFETYLSLLISLLSREASTEVVLEGIIPMILEQTKEPAEISSRFAKALMLSSIAPSYTQSGLPATTITIPADGHDVTSVTALLSGYQKYVDSTPVPRIGISLIYGDMNDQQNQLRYHLDPIASLVRSGGIISLSHDDGLRASSGIRKSIRGKSSGTVITLQSLSINLPRLAYQSNKDETYFRARLALMIKPALAALYIRKKAVAELIRKGTVPALSGNSDFIQSGTTNIIINLIGARESVNDILGHHSKNNGMEVLQKVLKTSVDVALDQGRYIGEGSVGVAMIADDSATRFATLDSDKYGRAYLQSTQQNSTTYSQGLTLYGEQLLMPNDDNSGSLIEECLSVDKLLSGGLSITLDVTELASNHVQLKKAIEAASGIPFFRPMVKLMVCNSCGKRSGSRYQERCEFCGSSHMLLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHX9</accession>
    <name>A0A6A8FHX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_01745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000057">
        <property type="protein sequence ID" value="MRN68402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="491" mass="52820" checksum="F35B1E1C4FB166C8" modified="2020-06-17" version="1" fragment="single">MMIGIAGLVGGAIFVLTGPAIGLAGGSVIVAFIINAIITLFTAMGYAELGSAIPEAGGGYLWVREGLPRPNAFISGWMAWFAHIVAGSLYAVGFGSFLFSLLKMVNILGDHPLLGIIPFDKLIAVASIAAFTYINVKGVSETGKAGTIVTIVQLGAIAALIGAGFWTIHTHPNWKANFADFLPNGIGGIVAAMGLTFIAFEGYEIIVQTGEEVKNPKKNIPRAIFTSLAIVVVLYCLVAFVSIGAIFPPGVPAWKYIGHYGDLGITKAAALFLPYGAFIVLGGGIVSSLAALNATTFSSSRVSFAMGRHYNLPHRLSTIHPRHKTPHVAIGISGVIMAVMAYALPLDQIAVAAGVIFLLLFTQVNIAVINIRRMYGDKLNYGFKIPFFPIIPIIGVFLKLGLALYLLVTQPLSWVISALWILVGFALYRMYTFKKEIEHYAPIVTSEGHLTRNEYRILIPYTPENPDRLIKYAIRVAKENDGEVNVLRVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHY5</accession>
    <name>A0A6A8FHY5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hel308</name>
        <name evidence="4" type="ORF">FIO04_02640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000102">
        <property type="protein sequence ID" value="MRN68576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="233"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="713" mass="79836" checksum="25443E3D90A10865" modified="2020-06-17" version="1">MTMEDPRINNLLDLLGHSSLYPPQQQAVSHGLLEGKNLLVTTPTASGKTLIAIMAAIKAIEKGMKVFYLTPLRALAMEKYHDIRVLERLNILDRKIRIKVASSDYNSTARELEEADVLVLTNEKMDSLIRHESSWISDVGLFVADEVHLIGDRERGPTLEMILAIIRKVHPHAQILALSATVSNSADIAEWLNCDLVETNWRPTKLFEGVYENGTILMNDGNRVKIHSYSNAAIDVAIDSIDKGGQALIFAGTRKRACSLAAKAAEGVLRRLDRTEKEKAATASLQIRTKGEDLELTSNLSTLVSKGVAFHHAGLGASSREIVEEAFKTGVIRLLVATPTLAAGVNLPARRVVLSSVLRYNADYGANMPISVLEYKQLCGRAGRPKYDTFGEAIIIAESGVGSTDLYEHYILGEPEPVRSQLINDRALRIHVLSIISTIPGMKQGEIYDLFGTTLCAQHHKRAVIALKIDTALRYLENENLIKSKNERYIPTNFGRRSSLLYIDPLTAVEFKRAIESAEQSNANPNDGVINHTLGFLHLITSCADFYPKFSMRRKDLELTAIIDEHRNELFYQISEFECSRSLLALHEWIHETSDRNLSDRLSVEPGDMHRMVEIADWLAHSLYEVAKLLKRGDLLRELHDLKIRIRYGIREELIPLVRLKEIGRARARALYDAGLVDARKVTETPEAKLSAIPKIGPTLAKRLKEQIKKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHZ0</accession>
    <name>A0A6A8FHZ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000058">
        <property type="protein sequence ID" value="MRN68412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6246" checksum="D8D35FF6F625D4F7" modified="2020-06-17" version="1" fragment="single">PGTIYPALKSLREMGFISSEEKEGKTIVYSLTERGKNALRIAKQRFIRTFLGVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI06</accession>
    <name>A0A6A8FI06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome assembly factor SBDS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO02_01585</name>
        <name evidence="5" type="ORF">FIO04_01830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000014">
        <property type="protein sequence ID" value="MRN39727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000059">
        <property type="protein sequence ID" value="MRN68418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="99"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="229" mass="25767" checksum="2D15DD8229F59B13" modified="2020-06-17" version="1">MVENKITTVRLTLDGNKFEILVKPDPALEYKLGKRTDLSGVLISDEIYSDANKGSRAASEKLAKYFKSTDPMEVARQIISKGDLSLTTDQRRKMVEEKKRQIIQYINKSFVDPKTHIPHPVMRIESAMSEVRLTVDPFKPAEDQAKNVVDALRRILPLKSENLLLTVTIPAQFSAQSYNLLKTTSNFKDEQWLADGSLRVILEINAGMRSSLLDRIGSVSKGTAQVMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI11</accession>
    <name>A0A6A8FI11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000064">
        <property type="protein sequence ID" value="MRN68432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="239"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="475" mass="52342" checksum="67C13BDF124D5BC3" modified="2020-06-17" version="1">MSKLERISTGVPGLDSLIEGGIPKGSTLMVVGNSGSGKTILCSHFLYDGLTAKEEKGLYISFSESKAQFYANIKTLGMDFDKFERQTKFAFLDFASLTKDGIQDALEEILATIRTINPKRVILDSFSAISLAFEHQSEARTTIHVLLGKILRSEGITSILVMEIPYGKENMGSGIEESVVDGIIQLDHREDNVLPIILRVFKMRGTSINREPHVCTISKNGMILYPKQGLRLTYAASEERIFSGIPGLDERIGSGFIKDTTTAIIGTSGTGKSTFAFQYIAEGVRKGEPGVFYSLEENADGIRMMAKGYGYNVTELENNGLSILLGSVEDDNPDALIANLAAEIKRTKAKRLVIDSLSAFESKYKNDMYIIARRLISLIQEHHLTAVITILTTQKSGFELSGLGLTSLLQNIILLRFVEIQGRMKRILAILKMRGTEHDESILEFRISSENGARIVGAIDKDYMGIFTGVARRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI40</accession>
    <name>A0A6A8FI40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000208">
        <property type="protein sequence ID" value="MRN68901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="98" mass="11276" checksum="28479BC1D08CC8D5" modified="2020-06-17" version="1">MKKIFGNTTGILDGTSILKIGENGKWNKSNIMTNRLLFGTLMSPTSVATVHQLLLSQFNWLHWERVEQNASIDAIVFDEIHPYDFYTFLSKLFDEPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI52</accession>
    <name>A0A6A8FI52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_02085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000072">
        <property type="protein sequence ID" value="MRN68468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="238" mass="25734" checksum="922F8097DF39AAE0" modified="2020-06-17" version="1" fragment="single">MVRFYRSIRDSPVSEADIILIGVPDESKSLAKRKGTNRAPDIIRLASNDSEFFEREEKTIPVLPMRGSFDDKRILDAGNVTREQLPQMIADIVSAKKIPIIIGGDHSITTIALRAIGGVLGKIGLLYFDAHPDFVSSMKNYYGSVLTDSAQSIEYKKSMLIGTRAAEPEELENAQNAGLEIVSPLDFVELGVLKIADKVVAKATGPKKYISIDLDCIDPAFAPGVSLPSAGGLSSIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI60</accession>
    <name>A0A6A8FI60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="141" mass="16583" checksum="7F249AFF11D9FB91" modified="2020-06-17" version="1">MFDENSAGAILYSLNEDLLRTEYLLLHHTSGHWDFPKGNIELGEDGFQTARREIYEETGINDIEFVKGFISTIEYYYRRIDKLVHKRVIYYIAKTNTREVILSSEHDGYAWMEYDTAINQLTYKNAKQLLEKAKTFVAPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI76</accession>
    <name>A0A6A8FI76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000317">
        <property type="protein sequence ID" value="MRN69145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="53" mass="5723" checksum="29BB3197E1E0CF30" modified="2020-06-17" version="1">MQFRYNRTTGVIIVVGFILAAVIAGIGVVSALTISSSGQTFLKAMWRNTDEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI89</accession>
    <name>A0A6A8FI89_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_07660</name>
        <name evidence="3" type="ORF">FIO04_03140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000149">
        <property type="protein sequence ID" value="MRN40901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000132">
        <property type="protein sequence ID" value="MRN68676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="159" mass="18334" checksum="ADD55FEC62CACECC" modified="2020-06-17" version="1">MSSCLFSYNLGTLIDRRAKDIITRARVARLATVDCYNQPYVIPVVFVFDGAYFFIPLDRKTKTVTPGELRRVKNIEKNAKVALIIDKYTEAWEKLWFIMIMGQAGIIENKDQIALLKEIHKMLITKYPQYKSLGMGESCIKIQPLKVTSWKNAMDTVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIG5</accession>
    <name>A0A6A8FIG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000276">
        <property type="protein sequence ID" value="MRN69054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="97" mass="11283" checksum="3C3E3D8FBBE55989" modified="2020-06-17" version="1">MTDPNAKRLLWFIFAGSRGGDNRMKIIDLLKERPYNINQLSESLGLDYKAIQHHILVLQKNNIITKMGEKYGVLYFISNYLEANIEAFNEIKSKINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIG6</accession>
    <name>A0A6A8FIG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO03_06180</name>
        <name evidence="7" type="ORF">FIO04_01415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000223">
        <property type="protein sequence ID" value="MRN61623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000045">
        <property type="protein sequence ID" value="MRN68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="229" mass="24190" checksum="977A2F3E5ACE472F" modified="2020-06-17" version="1">MRDIVFGFGDGINTSLGIVAGVGGAQISADVVILAALVGMFTGAKAMAVQNYLAVKSQREILESEIRREEFEIENLPNKERQEIVDIYKAKGFQGDELQKVVDKITSNKDVWLKTMLTEELGLNLEILGSPFRGALVMFGAFLLGGILPILPYFAVKAGLISSGVSIAIAIGVSVVSSFIVGAIKGRMAKKNWFKGGIEMAGLGTGVALVGYGIGAELVKIGLINVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIH5</accession>
    <name>A0A6A8FIH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_02750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000108">
        <property type="protein sequence ID" value="MRN68598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="53" mass="6161" checksum="B0C7C6F80E724E35" modified="2020-06-17" version="1" fragment="single">MIMAPEWIKACEVKELNNSELVGFDFNEKKILISKIRNKVYATDRICTHAYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIJ1</accession>
    <name>A0A6A8FIJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000376">
        <property type="protein sequence ID" value="MRN69255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="46" mass="5008" checksum="D3FC23C259680CFD" modified="2020-06-17" version="1">MNALEEPSMKRWRKPGEVSKIVARVASSSFSFATRNTPVVGGCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIJ8</accession>
    <name>A0A6A8FIJ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <shortName evidence="4">HK</shortName>
            <shortName evidence="4">HSK</shortName>
            <ecNumber evidence="4">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thrB</name>
        <name evidence="7" type="ORF">FIO04_00010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="90"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="224"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="321" mass="34109" checksum="A3C49BD6FE653AB7" modified="2020-06-17" version="1">MNHKLGSTSVTAAAPSSTANLGPGFDVFGLGLDAFEDKVRITTRSEQSEQITIRISGEAVKSVPSRVQDNCAGVVVKKMSQDFSIKNNLDINLEKKVPAGMGIGSSAASAVAAAVAFDRLFDLKIEKTKLVEYAAQGEIVSAGAKHYDNVSGSLLGGFVIVRTSPRLEFIRLAPPEDLLMIIAIPLIEVPYKKTEVARGVLPKNVSLKSVVHNVSNASTIVAGFLLKDVEMITRGIDDMIVEPLRKDLIPGYDAVKKKALKAGALAVTISGAGPSMISFLKDDKFGKRVADSMSEGFKEANVQSRTLACHASKGARVLLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN7</accession>
    <name>A0A6A8FIN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000313">
        <property type="protein sequence ID" value="MRN69134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="100" mass="11564" checksum="5AB2CB05BCB6A989" modified="2020-06-17" version="1">MNDILKALLDNNNKCISNQELEWLLQKIENDATEIGHAKYGLDEKMKFNIEFDNAPNDNLIGRQSLTSLECIRQSIKKNLELMNENIKTIFQSYLTQCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIP6</accession>
    <name>A0A6A8FIP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000130">
        <property type="protein sequence ID" value="MRN68668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="340" mass="37884" checksum="E0E20F2F475E7C78" modified="2020-06-17" version="1">MTILIAAMQDLLLSLESSKTGWKTHESLKGTHPQSVTFDPRNPNRVYCGTFGDGVWKSDDGGQTWDRVGKDAISSNDVTSVSVSRLERRNKVYVGTEPSALYRSDDEGHSWQRMSTLNNLESSKSWSFPPRPWTSHVRWIESDANIPDYLFVAIEAGALVQSRDGGRTWIDRVEQGPYDTHTLATHQKAPKSLYSSAGDGYFESFDYGESWKRPTAGLKHHYLYGLAVDPADPHTIVVSASQSAWQAHSVEGANSLVYRRSLENDGGEWKAISNGLPESRGTIIAILAANPKNSGEFYAINNRGVFCSTDTGLVWRELDVSWSKEYLLQHPWALAIRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIU5</accession>
    <name>A0A6A8FIU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <ecNumber evidence="8">6.3.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purL</name>
        <name evidence="8" type="ORF">FIO04_03325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="8"/>
    <dbReference type="EMBL" id="WJXC01000144">
        <property type="protein sequence ID" value="MRN68712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="7">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="5">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="6">
        <location>
            <begin position="196"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="425" mass="47110" checksum="D14CAC763ADCA7A6" modified="2020-06-17" version="1" fragment="single">MAALTKEESRYLAYKLNREPNKTEKEIVAAEWSEHCSYKSSKRFIKMLPSKGKHVVVGPGYDAAVLDVGDGYVITVHIESHNHPSAVDPYGGAATGVGGVIRDIISTGTRPIALLDALRFAPLHKEDNEDGSSNSEWLFRHVVRGIGDYGNCIGVPTVAGEIEFDPSFINYCLVDVASIGFGRRDSIVRNRANYDDLIILVGGPTGRDGIRGAAFASKTYLHHNRSAVQIPDPFLEKLLIEAITEAVEEGAIKALKDLGGGGLSCCLSEMSDNLEKGFDIELSEVHVKEKGMSPLELMLSESQERMLIITDHLKIDNIRRIFDKYELKYVILGKIKDHHNLVIRCNEKIVANMPSNIVANAPLARRFSKRPAYLATLRLDFTPPVTPSNLTRVLLSMLSNPTIASKEWIYRQYDHEVGLRTMVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX3</accession>
    <name>A0A6A8FIX3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="4" type="ORF">FIO04_02245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000081">
        <property type="protein sequence ID" value="MRN68499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="3">
        <location>
            <begin position="171"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="420" mass="45535" checksum="C1A7B876E7A0B880" modified="2020-06-17" version="1">MPSTGIVKYHVKLKFEVDGLVEKADIIGAIFGQTEGLLGPEMNLNELQKVSKVGRIEVNVDTKSNMAKGDAVIPMSTDISTAALIAAAIESIDKVGPFQAKFGLSGIDDIRAIKKKVIVDRAKKIVQEWATKTISEGEEMLKDVYDASKPGKLTAFGKAQLACGTGVFDSDWIILVEGRADVINLLRAGFDNAIAIEGAKIDETIIKLTDGKKVIAFLDGDRAGDLILKELHGVVNIDKVLRAPTGREVEECTPLEIAEILKEGMLFAGANGQEGRVIIPQQQQPERRQNTKRDRQEQGMGEEREIQVNSGGSSVTVSEDNADILSAVKEVYPQINETLEAVVLDGSMKILLKVPVSDVIKKLDKTEGAKLLVLDGIVTQRLVDAADKVGIEYIVGHRTADLKKSTDVRVRTFGDMGIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY1</accession>
    <name>A0A6A8FIY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000164">
        <property type="protein sequence ID" value="MRN68768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="37" mass="4128" checksum="D46F07AFAAEEA7A7" modified="2020-06-17" version="1" fragment="single">SMKMQVAIKAHKDGNIREIKVKQGTTVGRYDVVAIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY8</accession>
    <name>A0A6A8FIY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000470">
        <property type="protein sequence ID" value="MRN69405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="78" mass="8665" checksum="187067657C0BE4E4" modified="2020-06-17" version="1">MGANSNSVLSLIPVQSLLSFGERHLISNYKYIQVMIGGRIYFVSLDEWVPQSTTYIIREKGSGSLVGIPKVSDGFNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ33</accession>
    <name>A0A6A8FJ33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000502">
        <property type="protein sequence ID" value="MRN69455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="44"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="245" mass="26565" checksum="A038AD7CD3AAA536" modified="2020-06-17" version="1">MAFALLQIIGIRGIFLFSLIPGAIAVVILIFIVKDVAAKRRINTTMLSNVGNVLKGNRPFVLLLVISGIFSLGAFNYSFVLLKASGLGINKNVIPLVYAVINVAYTIVSFPAGLLADKIGKEEVLIIGYAIFAFSTLLMVEFTGNSLYAYLLAAVFGTYMGISETLQRAIIPRYIASELRGTAYGVYNLVVGSGFFASNIVFGFLWDNYNLNFASYYSVTFALAGIIGMLAFIRKFPVSSASLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ35</accession>
    <name>A0A6A8FJ35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="7" type="ORF">FIO04_04425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000220">
        <property type="protein sequence ID" value="MRN68926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="294" mass="32692" checksum="7E14233E6E24861F" modified="2020-06-17" version="1" fragment="single">MRDDNSKNNRSNIQVDITTTAAATIAKCQSCGNDQIITDSESGEMICDKCGLVISDKLQEIGPEWRTFSTDEMGERTRTGPVQSLARHDMGLSTIIGRTDRDANGNKLDVAMRTRMSRLKTWDSRSQIHTPTERSLQQAFFQLDVLKDKLGLSDVIVEKSAYIYRKAQARMMIRGRTISGVLAAAIYISCREMGAPRTLKDIATACNVKRKELSKDYRMLHSRLDLKIPQLEPMKCIAKVANIAKLGERTKRQAAEIMSNVTKKEISAGKDPMGLAASILYLSSIKTGEIITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ59</accession>
    <name>A0A6A8FJ59_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">uppS</name>
        <name evidence="3" type="ORF">FIO03_05895</name>
        <name evidence="4" type="ORF">FIO04_00885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="WJXD01000206">
        <property type="protein sequence ID" value="MRN61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="242" mass="28351" checksum="E513AF393810B198" modified="2020-06-17" version="1">MESQILNNSLPNHIAIILDGNRRWAKYNFMRAGSGHFMGADKAEELLNWIHELGIKITTLYVLSTENLDRKDEEVDNIYRLLQLKLEKLYKDSRIHRRRMKIKAIGNVKLLPTELQEILNKLEEDTAKYNSMFLNIAVAYGGQEELVDAVRKIALMTKTGELSVEDIDEKVIESCLYTSHLPQPEPDLILRTSGEKRLSGFLIWQSAYSELVFMDVFWPEFRKIDLMRAIRTYQRRIRRYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ67</accession>
    <name>A0A6A8FJ67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000232">
        <property type="protein sequence ID" value="MRN68956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="50" mass="5944" checksum="9ED64C18CE0E331D" modified="2020-06-17" version="1">MERIEKEEQAKKLIKYLYSQNNNNQKGARQQQYPITFVTHAISRTRTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ74</accession>
    <name>A0A6A8FJ74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_09050</name>
        <name evidence="2" type="ORF">FIO04_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000210">
        <property type="protein sequence ID" value="MRN41175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000029">
        <property type="protein sequence ID" value="MRN68257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="110" mass="12970" checksum="D37BCEAFF66FA005" modified="2020-06-17" version="1">MGEIKENEVSLNEPNAEYVHLIEDVNVWFIDYVIGVAFRTPINFVDKMNGLSESGRPYREFSDYKDMQDYLDKITGQEIVIESSIDPRTDTEFDSRIVWETKLKEFVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ91</accession>
    <name>A0A6A8FJ91_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4147 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000427">
        <property type="protein sequence ID" value="MRN69344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="333"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="451" mass="49097" checksum="8DC4D41FD63A7EEF" modified="2020-06-17" version="1">MKISLSALEFCLRKSDPKKLVQNAVKLRNSKLLLTDIRNNIIKLDLDDYESIYVVGAGKASARMSDAISTILKKRLSGGAINVPQDMVKNKIGRVIKTRQIKVTEAGHPLPDKAGVQGTIKIVELVKKATERDLIFCLVSGGGSALLPLPLKGISLHDKQKITDAMLSVGATINEVNVVRKHLSLVKGGRLVRYVKSGCTVVTLILSDVIGDEIDIIASGPTVPDRSTFQDAAEILKKYRLWQKPFTSVRRLIMKGINGEIEDTPKEGDPIFEKVHNILIGNNSLLCDYAAQYLGKHVSTVMNLGSSFAGEAREFGYYLADLGKDAIRSPESVALVMGGETTVKLNRFKRNGLGGRNQEAVLSAALKCRFPPRVDIAILCLGTDGVDGNSKAAGAILTPETMSRIKASGLKVKEYLNRHDSYRALRKLRSIIVTGRTGTNVNDIAIICRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ93</accession>
    <name>A0A6A8FJ93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Archaeosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="7" type="ORF">FIO04_04140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000197">
        <property type="protein sequence ID" value="MRN68872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="242" mass="27936" checksum="5C95462F85830CDE" modified="2020-06-17" version="1">MLTNPNTIQLSEIFTSIEGEGILFGTKTLFVRMAGCHLKCRWCDTSYALPMYSGNSYSLEYVKKLIADHLKPFTYKVNFTGGEPLVQYEAVIDLAKFVRERGLRTYLESACYDSDRFAKLLPYIDICKVEVKMSDSKVVDMNHYDNLLQNEIRCLRTSVKNHKITYIKIVVTNSTDIKEFADLVENIFQHVSTADISGFIIQPSDRIDEPTTERLLQFYDIVCPHYREVRIIPQLHKQIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA9</accession>
    <name>A0A6A8FJA9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FIO04_04775</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000249">
        <property type="protein sequence ID" value="MRN68996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="407"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="363"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MRN68996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="600" mass="67100" checksum="8A75A0044CE19B3C" modified="2020-06-17" version="1" fragment="single">MEIKSKLFIIMVSLVIVTLLVTSIISLNSFSTGMISEIRKHLQNNTASTMDKISETMFDRISDIRFLTDRNNVILSEPSPTEKKLEYLNSVLRIDRHTYDLAAIFDNNGKEIGDTSNASVIGTDRSHESFFKSAVRGVIYFDKVPVISNNSLNHYVIRVAGPLYATNGKIYGVLLLEFPFSKISQILQTGTTLPHTEINLVSNNGSIMYSTSYDNSNLQKSLSRLPIFAKIKNSSNSIESLIATNFNGQGDALYVAAKDKGYLDYPGSGWFLITAQATEQAFSRVLDLRNSFIIATILILSVAIIAVFFVARTISKPITELKDAADKISKGELDLNIKVTADDEIGDLARHLDDMRVSIQTRDRNLRLQKEGLEKANKELTTKEQELEKAYDTLKASEKAKEEFISMVSHELKTPIVPIKIYSEMLLKTDSLGVLSAKQKKVMHTVVRSVEKLEALVGDVLDVYKLDMGKLTLSKQVVDIAELINRTISDLTPITLEKQIDLKSDIRTTKEDVVFCDPKRIEQVLWNLVKNSVDFVPEKGGRIVIRIEKEPNSNSHFIFTVEDNGIGITSVERHNLFNKFYQADTSFSRKHGGTGLGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB3</accession>
    <name>A0A6A8FJB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate dehydrogenase iron-sulfur subunit</fullName>
            <ecNumber evidence="3">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdhB</name>
        <name evidence="3" type="ORF">FIO04_02570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000097">
        <property type="protein sequence ID" value="MRN68563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="250" mass="28008" checksum="1364010DFC43AFCB" modified="2020-06-17" version="1" fragment="single">MLRTGSKHERSEKSLRARSSIVLRVYRANKAIGDSAHYDTFDVPIQRWTTVLDALLYAKSYKDTSIGIRYSCRMASCGSCGMKINGIPRLACYTNVSELESGVISCEPLTNFPLIRDLVTDFYQFFSHHKSVRPYIINQNADIRDSKELSEFIQSPRDVDEYLQSSYCIKCGLCYSACPTVATDTKFPGPQALAQAYRYSADTRDTGSREDMKAIDDKHGIWRCHFAGSCSSVCPKGVDPALGIQLLRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC8</accession>
    <name>A0A6A8FJC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000039">
        <property type="protein sequence ID" value="MRN68307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="59" mass="6271" checksum="8AAFAF5B556C2F93" modified="2020-06-17" version="1">MTINSEAINFYGTLKGMIGIQNRPSTDNAFEGEKGILGLIDPPAVLYGTTEIGNTKNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD6</accession>
    <name>A0A6A8FJD6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate dehydrogenase</fullName>
            <ecNumber evidence="2">1.17.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_00440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000011">
        <property type="protein sequence ID" value="MRN68150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009326">
        <property type="term" value="C:formate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="5">
        <location>
            <begin position="33"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="6">
        <location>
            <begin position="123"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="351" mass="39157" checksum="4A41091C5E825959" modified="2020-06-17" version="1">MKIVAVLYPGGEIAKKTPELLGCAENALGLTDFLRSQGHEFVVLTDKEAELDKHLPTTDILITTPFWPAYVTKERISKASKLQIVLTAGIGSDHIDLAAAAARKITVAEITGSNVVSVAEQVVMHILALVRNYIPAYKQVLDGRWDIAEIAAKAHDLEDKVVGIIGVGRIGQRVCERLKAFDVKMIYYDYHRLSTVEEFALGARYANLDQLVEQSDIITINTPLTPETDGMFNRDLLFRMKKGAYLINTARGRIVDTLSLVEALEKGHLAGYAGDVWFPQPAPKDHPWRRMPNHAMVPHYSGTTLEAQRRYADGIKDCLLRFMNGRRIERDYLIVDNGSVVSPSYSYAFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF7</accession>
    <name>A0A6A8FJF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prolyl 4-hydroxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000130">
        <property type="protein sequence ID" value="MRN68669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018655">
        <property type="entry name" value="DUF2086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09859">
        <property type="entry name" value="Oxygenase-NA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="234" mass="27201" checksum="AF57676CEB275057" modified="2020-06-17" version="1">MSEKISGIDWQRVTEEVNEKGYALVLQFLPNQYCEELIGEYDNSDLYRKTITMERHGFGLGEYKYFKYPLPDLIQTVRRAIYPKLTPIANTWMRVLNIKRQLPDQFDEFQRLCHDNNQTKPTVLILKYGKGGHNTLHQDLYGNIFFPFQLVLFLNEPDDDYTGGEFVLTQHTPRAQSKAIVLRPSKGDMLILTTNFRPVKGSKGYYRVQMKHGISEVHDGDRHTLGIIFHDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF9</accession>
    <name>A0A6A8FJF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDC48 family AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_01455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000047">
        <property type="protein sequence ID" value="MRN68347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="225"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="498"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="735" mass="81241" checksum="F4097AF5EB610DF8" modified="2020-06-17" version="1">MKKSRGRSNDASDESSPKLHLRVLEAKHRDLGKRRARIDSNSMRRMGIEPGEVIELVGKRKTPVTAWPSDQGESESDIIRIDGQTRKNAGVALNDLLSVHKAKSKSAKAVGLMPLGSSTVSFDREFCEFVKNRLRGFPVTEGDEISVVILGNPMDFRIEKITPRSIVKIERSTKLNILAEGSLDKKPRVTYEEVGGLTEQIKRLREIVELPLRQPEIFARLGIEPHNGILMYGSPGCGKTLIAKALASESEANFFIINGPEIVNKYYGETEARLRDIFKEARDASPSIVFIDEIDAIAPKREEAFGDVEKRVVAQLLSLMDGMSERGNVIVLGATNRPESIDPALRRPGRFDREIEVGVPNVVGRLEILQIHTRGMPLSQDIDLPVLAKELHGYTGADIKALCREAAMKALRRYLPEIDLEEEKVSPSTLEIMDIRNKDFKDGMKEIIPTAMREFYVEAAAVRWEDVGGLYDAKRTLYYNLITAIKEPENFIKMGVKPPRGALLFGAPGCGKSLIARALATESSANIIMVRGPEVLSKWVGESEKAVREIFRKAKASSPCVVVFDELDSLARPRGGDDLSGNERVLSQLLTEMDDSGSAGVIVIGITNRPDLIDTSLLRPGRLDLIMFIGAPDEKGRLEIMKILTASMPLANDVSMENISQSTKGFSGADLGALCREAAVNAMRCKSDIITNTDFGSALHLVKPSITKDVEDWYESMKKSITYSMPKQIDKAFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH7</accession>
    <name>A0A6A8FJH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translation initiation factor IF-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000285">
        <property type="protein sequence ID" value="MRN69076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="39" mass="4158" checksum="B7418087B29A6806" modified="2020-06-17" version="1" fragment="single">MQLRQPVVVVLGHVDSGKTSLLDRIRGTAVQAREVGGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ6</accession>
    <name>A0A6A8FJJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000054">
        <property type="protein sequence ID" value="MRN68387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6364" checksum="B1FAE7801E1F0988" modified="2020-06-17" version="1">MNPSIGVIKYSLHKQIRELYEKKDAVNTEVEKLEIQSQINAIYDKIENLCLIGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL2</accession>
    <name>A0A6A8FJL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FIO04_03365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000147">
        <property type="protein sequence ID" value="MRN68719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="241"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="437" mass="48092" checksum="D95A05FE7A9915AD" modified="2020-06-17" version="1">MKVSISGIRGIYGNDLNLHEVIKFSRLFASCLIRPKGKCVLARDTRHSGKIILQAVSASLMEQGIDVYVLDVAPTPMVFRETRKYGAGVVVTASHNPLEWNGLKFVVDGRGIYENELDLMLKGTTSKSDKYGKSYDIVSEYLNELFDLVVQAGTSRAVTLGFDLGGGATCSYVEGLFKKLGHKFHCVNDVPGISSRGPDPTIDALNELRTLVQENELDFGFAFDLDGDRLVVVNNRGEKLNPDSTLLLCIASALKMGMKKFVTSIDTSVSVEKLIKSHHGRTEYSKVGEANVVKRMLELDADAGGEGSSAGFILPRFNMCRDGFLAAATVSSLDRATINECLRLASEYVQIRSKICVKSTVHLKLLDKLLDQFGSESSQILTIDGVKAIFDEDSWVLVRPSNTEDAIRISVESKANNAQSLYKKIMEKVNLIYERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN2</accession>
    <name>A0A6A8FJN2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Rrp4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rrp4</name>
        <name evidence="6" type="ORF">FIO04_01825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000059">
        <property type="protein sequence ID" value="MRN68417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00623">
        <property type="entry name" value="Exosome_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023474">
        <property type="entry name" value="Rrp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH" evidence="5">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="269" mass="29671" checksum="0D1C79496ECC7D8A" modified="2020-06-17" version="1">MQEIRRKYVVPGDRIIEGNFRPLFNVIKAGNSIISTRIGIAEAGREGVKVIPLSGVYIPRVNDIVIGKIMHHSSLSWEVDINSCFSAHLPAQDVFGRDFSPARDDMGRELAIGDLITARIIAFDRTRDPMVTIQDKDLGKVPSGEFIKISATRVPRLIGKRGSMIQTIEQATHTRVLIGQNGIVVVTGRNSEGIKLAVRAIRMVEEEAHTPNLTQRVKTLLNVSDSAPADTSQLAPSQNAPQNEELQPTIQEVEEELEVEKGEKVHDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP4</accession>
    <name>A0A6A8FJP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acs</name>
        <name evidence="7" type="ORF">FIO04_04985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000269">
        <property type="protein sequence ID" value="MRN69038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="6">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="5">
        <location>
            <begin position="532"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="625" mass="70659" checksum="74F6E3DB1E58E0C3" modified="2020-06-17" version="1" fragment="single">MTDQNFIDLSRIYEESEKVKVSLQGKKLDKMRSQALEDPEQFWGEQAKNLIWFKQWDKVLDSNDHPFYKWFVGGALNASVNCLDRHVDSDLKNKAAIIWEAENKESRSFTYSQLYRSVNKFASALKNLGVKKGDRVTIYLPMVPELPIAMLACARIGAIHTVVFSGFSAQALSDRVNDSNSRVVITADGGFRRGKLVELKKVVDEAIPLSSSIEHVVVLKRALNNITMGPKDVWWHEIIEDARPYCEPEIIESTHPLYILYTSGTTGKPKGVVHSTGGYLTHLYATAKWVFDFTNKDIFFCTADIGWVTGHSYIVYAPLMHGVTQIMYEGAPDYPKPDRYWDIVEKHGATILYTTPTALRMYIKFGNSIPNSFDLSSLRLLGTVGEPINPEVWMWYFRTIGKENCPIVDTWWQTETGGIMISACPGIEIVPMKPGSGTFSLPGIDAVVVDENGKPVTPDKKGYLVIRKPWPGMLMTLWRDDEKYQNTYWRKFDNNIYFTGDYALYDADGYLWLLGRSDDVLKIAGHRLGTMELESAFVSHRAIAEAAVTSRPDEKKGESIIAFLVLRTEFATVSEQQLRNELVNHIRETVGPIATPGEIYFVNKLPKTRSGKIMRRLLKSISSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ8</accession>
    <name>A0A6A8FJQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000323">
        <property type="protein sequence ID" value="MRN69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="78" mass="8523" checksum="929C96DF4A5A7F6C" modified="2020-06-17" version="1">MISTAPPSSPYAAYLGLDTMIPPLVSLAVFVGVSLRTQKLTPPRHDVIYLIPSDMDTVTGADVSEWVQPIDVRQVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR5</accession>
    <name>A0A6A8FJR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000542">
        <property type="protein sequence ID" value="MRN69514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="113" mass="12439" checksum="9A770440F6BEDF37" modified="2020-06-17" version="1">MTEEVNKRLIQFLNDGQNWERKATNIPGAFLFRLPTSKGRPASLAIEINPIDTLGSITKKRGVVIRSSLELDEISGLLSHPKVSELSKKIDAVNPKREATTLTGKAGPDIFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK22</accession>
    <name>A0A6A8FK22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000183">
        <property type="protein sequence ID" value="MRN68833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="101"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="300" mass="32712" checksum="0756BEC078F983EE" modified="2020-06-17" version="1" fragment="single">MCKAELNRNKKTLLTVFIGITISMVFIIGSSNSLLSIALSKSSHHSKSSTITINSVSSSGSGNSGSILKGANSNPSISAEQSSSVTSNSVVSSNAKNNNNKVIVLSFDDNRIGDFTYAKPILDKYGFKATFFIICGKTTDSGAMNWQDIAAMQKDGMDIESHSMTHAHLNTLNQSQLNFEIGGSKQCLASHGYNATIFAYPYNEGSNNPVVVNTVAKYYDMARSGTDPLMFLDCKGFMKHPQTDCRTYTPDGKLTYANRYAIRSLSFDIIEIRDSFDNATMFSDFTKIINSQNSYNQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK52</accession>
    <name>A0A6A8FK52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000063">
        <property type="protein sequence ID" value="MRN68430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="234"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="451" mass="48880" checksum="2933CF5E3EC14108" modified="2020-06-17" version="1">MRTLLSLIDACSTAVREAVRNGATDAEAYGVNSKESEVIIENNDLKQSKSHEIGNLGIRVLVGSSQGFSSVNVFEKEQIIQSVKLAIKLAKVSPPDNFNSIPHKTAKISLLTKIYDKEALGFELSDNVRMAKDMLLTARSYDNRVSIDSGNFTSALLTHMVLNSCGISVIENISLFSWSLMGMAVTPDQVSNFDVQIDSSHCVKDIDVISTAKEFAKAVINYLGPRNVDSFRGEMILSPSASTELVQEVIAHSINSNNVQKQASKFKEDINSSVSTDLLNLEDDATNVDALGASSFDREGVDHRRNVIIEKGILKGFIYDTYTANKDSVKSTGNAGGSPKYPPMVSTTNMIVSAGNSKLETLISEIQKGVIINRFSGTVNPVDGDFSGVVKGGYYIKDGNIICPVKELMVAGNTFDALKNLTGVSKETKSLPDSILPYTRFSNISFTASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK58</accession>
    <name>A0A6A8FK58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000342">
        <property type="protein sequence ID" value="MRN69192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="66" mass="7081" checksum="D62F3FA29F918E3E" modified="2020-06-17" version="1" fragment="single">MGRYQVANYVGVFGFTFISILLILSKSVSPIGEFPPMAIAQQGIKDMTNATHFTAKGGVSNQTIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK66</accession>
    <name>A0A6A8FK66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000202">
        <property type="protein sequence ID" value="MRN68883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="322" mass="35947" checksum="6B3967D3E06A448C" modified="2020-06-17" version="1">MAKGKGVFSARLSAGVVILGVIAIIIIAIYYYYNYYPIRPFYPPPPTAGKLDKFGIKEIYLSKRGGEEWYLNTDNPQNGPRTGGEGPPPSFVQKNNDGSWKVQSSEVRYGVFTSSGYHPDLITTLNQQVLAAKGYMQSSNDWKNVEITGYFKVNSFTDSKQNGGPHIELVARGGRNTNDIGTIDGLSRQCEATTYHSNSYVDGRVKFEKDLEHIIGYTTGDPEKQHATSPLLGRWIGIKAVFYNLPDGSVRLEQWIDENSNNNWHRVLKYTDDGNWGGGTPNCGGPDTQIITWGGPIAIFRWDNIDDMDVKYFSVREIKPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK72</accession>
    <name>A0A6A8FK72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000068">
        <property type="protein sequence ID" value="MRN68450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="79" mass="9265" checksum="63C907713A925F94" modified="2020-06-17" version="1">MIGIEIKDLDQEIETRRFKLKTKLMNEHLVNESVYNRREFIRLHTTDTGVVCLVFTKSATDLIGYLLIGLFIVLRRPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK99</accession>
    <name>A0A6A8FK99_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">serS</name>
        <name evidence="8" type="ORF">FIO04_02895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000118">
        <property type="protein sequence ID" value="MRN68627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="138"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="6">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="425" mass="49080" checksum="86888B08205CAA20" modified="2020-06-17" version="1">MLDPKLLKENPQLLRSMLENRKFEFPLDDLIALDKRRRELTVQVEEFKHKKNLLARAISNKLKAHEDSVSEREEMKEIGTKLLETEQEKKVVDAKFRASMMTLPNIIDKSVPIGSDEKDNVILKYHGAIPNFDFFLKDHVDIANSLGLLDIERAAKIAGARFYFLKNELVKLNLALINFALDFLAEKGYTLVQPPFMIRKEAMEGAVILADFEDMIYKIEKDDLYMIGTSEHSMASMHMNEILDGKDLPLRYASTSPCFRKEAGAHGKDTKGIFRVHQFEKVEQFVYSRPEESELQHERMLAITEEFYEKLGIPYRTVLLCSADLGKTSSRTFDIEAWMPSQNAYREIVSCSNCTDFQARRLVTRFRDKINEQTRFVHTLNSTLVATERTMACIMENYQTSNGTVEVPDVLQQYMTGMKEISRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKA2</accession>
    <name>A0A6A8FKA2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 12" type="primary">gatD</name>
        <name evidence="12" type="ORF">FIO04_02150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 8"/>
    <dbReference type="EMBL" id="WJXC01000075">
        <property type="protein sequence ID" value="MRN68480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="SSF141300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatD_N" evidence="11">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase" evidence="9">
        <location>
            <begin position="125"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="10">
        <location>
            <begin position="347"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN68480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="472" mass="51717" checksum="9353F8F0674E3BC4" modified="2020-06-17" version="1">MSVRDKDNLTGYKEKSAELLRKQHVAVGDTITIKTSENEFTGILMPRYESADKNHIVIKLRSGYNLGIGTEKIRSIAKLTDPTRDVPDAPATKNMTFVDSFKQVSKEFKINQSINQNDRSKEHPKIALLGTGGTIASKVDYRTGGVSAALSASEIYASVPELENYASIEPEVLLNEYSENLKPADWTIIAHKIKEKVTSGKYQGIIVSHGTDTMHYTAAALSFALQNLPIPVVLVGAQRSSDRPSSDAALNLIGATIFAVKSELTGVFVGMHATTSDDVIACHLGTRVRKNHTSRRDAFESIDGVPIALIRGEILEMQLEQTGLKLRKRNNNTNGLVVRPDFDRRAALLKYYPGFNPEFISHAVAAGYKAIILEGTGLGHVSKDCFPQIRNAVESGTLIFMTSQCIWGRTRMTVYETGRDLLDIGVIPLSDMMAETATVKAMWALANSKDAKSATKLMQENIANEISMSIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKB6</accession>
    <name>A0A6A8FKB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000237">
        <property type="protein sequence ID" value="MRN68969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="118" mass="12627" checksum="1536F75719B3A202" modified="2020-06-17" version="1" fragment="single">MNISAVLLACIISTILVTGLISHAFAVQLTAFLSPQANSAQPDLTAVRFLTLNYDPGSALAQQFNGKAEHVRFTLNGTTGGMSQLISTFNQDIATEKQSPVRFNNATLQYQGDLIGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKE5</accession>
    <name>A0A6A8FKE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-4 C(11)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobM</name>
        <name evidence="7" type="ORF">FIO04_04660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000238">
        <property type="protein sequence ID" value="MRN68973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="258" mass="28407" checksum="FFCAD9D9A7E5E695" modified="2020-06-17" version="1">MIESNTVYFVGSGPGDPSLITLKAKELLERADVIVYSGSLLNPKILEDKKKDAVLHDAALIDREKIYEILRDSTKKGKLAIRFHDGDPSLFSAIREQIDKLEQDGIQCKVVPGITAILGAAAVMNLELTLPGNTQTLIITRAESRTPVPPRERISELAKHGATMALYLSVHLIAEVVQEIIDSGAYTKETPAAIVYRATWEDEKIIRGTLGDIVKKTHDAKIIKTAVIIVGDVIAPKKYEFSKVYDAGFTHGYRRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKF0</accession>
    <name>A0A6A8FKF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family 1 glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000255">
        <property type="protein sequence ID" value="MRN69009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="557" mass="63299" checksum="824AD958DA02BE00" modified="2020-06-17" version="1">MRQTHDFLWGVSTSPYQVEGGITNNDWSYFTTSESIKKRISSLTKPSLMYKDSTQVLLRPAGEAAKTWDPHYYLNDFDLATKLGMNAFRIGIEWARVEPEKDQWDQGAIDGYKQMIRSMRERGLNPVITLNHLTLPLWVLTPPSRFTKKIGQRLLPSPLRDLPLADPPASDPYWKSLRGWENYETVKEFIKFVTRVVQELKELVDYWVTIAEPVASVIGVGYIAGLWPPGFLLDGNRAKKVLHNLIEAHVQAYDIITSLDSIDADGDGISKMVGFSHAMVAASPAEPTKMIGATINDNIRAAANFDYFVNDYFINAVISGEEDLNYLNTLQRHNKDSKDFIVHEEWKNKSDFIGINYYRRVYVRYSNILALSSAKFAGGTFVNNLHAQTHHQPHGILNDLGWEIYPEGLYNLIMRIKNQWNNTLPVFITENGVADKNDKYRAPFIVAHLQQVKRAINNGANVIGYLHWSFMDNYEWLENYRPEARFGLFSIDRNVGKSGLPEFKRQGTKGAEALEFIIKQSIFRNENGVDTDSAITAAKDKFGTFSANGSHLINAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKF9</accession>
    <name>A0A6A8FKF9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 3'-terminal phosphate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rtcA</name>
        <name evidence="7" type="ORF">FIO04_04890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000259">
        <property type="protein sequence ID" value="MRN69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="5">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="6">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="269" mass="29114" checksum="FDC7346608F7A92E" modified="2020-06-17" version="1" fragment="single">MLTIDGAYGEGGGQILRSAVTLSAITGKSIEVINIRAKRHNPGLRPQHMHATRAVAEIFHARVENLKVGAEWIRFVPKPDNYEGGELRIDTGTAGSIPMILQTIIPAVALSGKSLSVQVTGGTDVKMSPTADYLRFIMHNAYKNIGINFSLNILKRGYYPKGGGIIQAEISPCKNISSFDLLNRRKVEPKIASVCCQLPKSVAERQISSALLRLERRGVRCNFYSSSFESSLSPGTSILVYSESDFGPYVGGDSVGARDKSAEKVGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKI6</accession>
    <name>A0A6A8FKI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000270">
        <property type="protein sequence ID" value="MRN69039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15839" checksum="B2DF3D63B237E0E0" modified="2020-06-17" version="1">MGFVDELPHLDQIKGNFSVSERDYQATAVIQEAQPITQSMYTTVRSFIEQQQYVFGTLWHKALPARQRIKQIEEHTKRDFIDTIQEGIEIDNLAHKLVGISKRRNSGNVSYHEYVLSLLDWAASRINRAGGSFWDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKJ8</accession>
    <name>A0A6A8FKJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000099">
        <property type="protein sequence ID" value="MRN68570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="182" mass="18955" checksum="E45070CEC5A33DE6" modified="2020-06-17" version="1">MDDLLAHAANDPDSDIETEESGRTGSPLSAGSALAPANTVHRNTLLSIFYDAAQASQERSTDDVARLPNHPSPDSLQSPTPPTSAFTTPMGSSSSLTTQKENQPSVHEESTRRVQGNPTSPQTLRPLGATSGAPLDERNSNGKRPQQPHCPFPALAKKSRGGATGRGASSGNTSSRGGSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKK3</accession>
    <name>A0A6A8FKK3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_07025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000489">
        <property type="protein sequence ID" value="MRN69436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="103" mass="11456" checksum="E65B723B52100859" modified="2020-06-17" version="1" fragment="single">IYTINYWSGMQKELDHAGEVETSLVLAISPQLVRMDKAEPNFKRLSKSRIAYSTITTTPGSFPKVTGNGVWGEPRSASKEKGDRLLKEIVGNLVHIISELPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKQ5</accession>
    <name>A0A6A8FKQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000460">
        <property type="protein sequence ID" value="MRN69392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="118" mass="12904" checksum="DF3F0E84A79BBBD6" modified="2020-06-17" version="1" fragment="single">MQRGYIILIIGTAFLIIGISVSAIWTSSLVGTITHQNTILNVVSINPLGDVNAITQISDINHPLSLVIHLESNGNPPLRETVRNPNGQIISTNEFSNQFLTRLKTDVVGKYILTINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKS4</accession>
    <name>A0A6A8FKS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000125">
        <property type="protein sequence ID" value="MRN68650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="122" mass="13822" checksum="B1D5B8AFF413D5C2" modified="2020-06-17" version="1">MTKIVWSSHNKQFLINELVWISISLVISFPSTISNIISSYCSNFFATRLVPRRKRLIATMAGSIVAGIFSALSLVDDSLKYYFMSGRTSHKQIACSSYSSMKRLRLSTHLNAGKKRSVYAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKT2</accession>
    <name>A0A6A8FKT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator MntR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mntR</name>
        <name evidence="6" type="ORF">FIO03_09230</name>
        <name evidence="7" type="ORF">FIO04_07035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000462">
        <property type="protein sequence ID" value="MRN62202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000491">
        <property type="protein sequence ID" value="MRN69438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN62202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="117" mass="13593" checksum="312BC5AD776231B4" modified="2020-06-17" version="1">MEDYLEVIYELIKQKGYATAVDISESLNVSSPSVTKMLQRLDESKYLRYEKYRGINLTNEGTSVAENIREKHYLLAEFFKMIGVDENTANIDAEGIEHHLHPETLKKLQHFIKGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKU0</accession>
    <name>A0A6A8FKU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000544">
        <property type="protein sequence ID" value="MRN69516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="292" mass="33280" checksum="C8F9379494777CD8" modified="2020-06-17" version="1" fragment="single">MEIPILVVNIILTAIMFAIFGVWIYLLTYLIKSYERSPRLKCFDKPLISKFPKVSVILPARNEEIYITRCLDSLLNQDYPNFEIIAINDSSSDETGDIILRYSKKYNKLVVAVDPGPKPDGWVGKSWACYQGYRKATGDLFLFTDADTQHSPSLMSLGVGHLLQQNLDAITAIPKLHCIETWTKITLPMLSTFLHTRFSALRVNDPRTKIGYFFGSFFIISRTAYEQVGTHEGVKQELVEDGALGGKVKDAKFRLKMVRGEENITAIWARDLNSLWHGLRRLMIPLYSQHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKU3</accession>
    <name>A0A6A8FKU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000488">
        <property type="protein sequence ID" value="MRN69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="70" mass="7587" checksum="1126D10AE4AD41FF" modified="2020-06-17" version="1" fragment="single">ITSVERHNLFNKFYQADTSFSRKHGGTGLGLAISKGIVEAHGGKIWVDDNYTNGASFKFTIPSGQGLNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKV0</accession>
    <name>A0A6A8FKV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000320">
        <property type="protein sequence ID" value="MRN69149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="148" mass="16016" checksum="926A82DB0882130C" modified="2020-06-17" version="1">MERQFDHRNAKYFLDLLTHTDNVIRTRAICILADVAGEDAVDDISNVLRSDKDPLVRHEAAFSLGQLGFTNAISALSGALSSDSSFFVRHEAAIALGVIGSESAKEALDKALGDGSEEVRESANIALANIDYISKMKRINKFSKMTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKW0</accession>
    <name>A0A6A8FKW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000494">
        <property type="protein sequence ID" value="MRN69442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="170" mass="20186" checksum="788943E7A15DF27B" modified="2020-06-17" version="1" fragment="single">TKLANARKIALSLRDLPLPHISDNDIQSEKLEMRYNKVVCRLRERIELDLPVVLTNANKVKELHEMRKDCKKLRYLLELVPHQNNDSIDNREIHKTITELEDIQDMLGSIHDIDITIAYLKRVRHPNEVTHILHDEISERNKKYEDFIQFYKRSLSDSRHNFLNQIAILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKW9</accession>
    <name>A0A6A8FKW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000501">
        <property type="protein sequence ID" value="MRN69452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="61" mass="6507" checksum="8D93C0E29CDE0055" modified="2020-06-17" version="1" fragment="single">MKSRRVRGRILGTGLLAASIVVFIAYSYVTLATSWGLLVLKLTIVVAVGALLAVLAWIGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL39</accession>
    <name>A0A6A8FL39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000203">
        <property type="protein sequence ID" value="MRN68887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="349" mass="38356" checksum="6ED9FD636D2417EF" modified="2020-06-17" version="1">MKAAVFREYSKDPTQVIKIEDIDMPKLRPNEVMIKVELASYNYNDLWAIWGEPIKTPLPHISGSDVAGTIVEVGEDVTKLKPGDRAVSHSNMSCRVCDMCTAGREYDCNDRTIWGFQTGPLWGGFAQYTHLPEVNVSKIPENVSFETAAAVSMVGMTAWHMLVGRARIRPGQTVLIMGGTSGVGMAGIQIAKLYNCTVIATAGNKQKMDKCIEIGADDVVNHREADWSKKVREITKKQGVDVVFEHIGKATFPQEVALLKIGGTLVATGATTGYDTTLDLRYLFFKGTNLLGSTQGTKAELEEVIYWTSRGKIKPIIDTVLPFSDMVRGHVMMAKAEQIGKILTTPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL62</accession>
    <name>A0A6A8FL62_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_00690</name>
        <name evidence="3" type="ORF">FIO03_03515</name>
        <name evidence="4" type="ORF">FIO04_03680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000005">
        <property type="protein sequence ID" value="MRN39551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000096">
        <property type="protein sequence ID" value="MRN61108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000167">
        <property type="protein sequence ID" value="MRN68780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="88" mass="10074" checksum="626ED62F4B294092" modified="2020-06-17" version="1">MKYRSRSDIVGLLLDAANGGGATKTKLMYKAYLSFNQLREYLALLVENGLIEYEEGMRTYRTTEKGMRLLQIQNTMDEITPINYISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL74</accession>
    <name>A0A6A8FL74_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000382">
        <property type="protein sequence ID" value="MRN69269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="70" mass="7399" checksum="A9DB633AF938362F" modified="2020-06-17" version="1">MFTASTLKKKALVFQGGGALGAYDTGVFQALYEKIGRKEGFDKLFDIVAGTSSGAMNGAIFFAIVPLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLB3</accession>
    <name>A0A6A8FLB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000185">
        <property type="protein sequence ID" value="MRN68840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="123" mass="14157" checksum="FC4F30FC70241552" modified="2020-06-17" version="1">MASIGSTSTIAKNLDEYQHIVCSEIRSIPDSNPYKKDLQKYRVLIIASFAKLNPILASLRSDKDLQEWNHFAQVLLTQISETLVKARVNQKRYDGTNSKLMRSAFDFFDVPEEEVDRMLQAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLE1</accession>
    <name>A0A6A8FLE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_04060</name>
        <name evidence="2" type="ORF">FIO04_04780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000052">
        <property type="protein sequence ID" value="MRN40200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000250">
        <property type="protein sequence ID" value="MRN68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="83" mass="9713" checksum="1D8301BF6826E142" modified="2020-06-17" version="1">MDPEQLLFERDRLMNRRVISSDLHEIGNIIAVDEDSLIILRDAENQYRIPKSRARAFIDNDLLVDFRLNDLLLIELASLSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLE2</accession>
    <name>A0A6A8FLE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000426">
        <property type="protein sequence ID" value="MRN69343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="105" mass="11700" checksum="C6C0A0A5FDF869ED" modified="2020-06-17" version="1">MNATDILDCSADFSMALPKTCSFRDKDVDCPLPPSYIVSIGDNSEEFMIAVVCQDHRDQMEKRLKAMQSARKIPQGKAKFQDIKLVVTDCIREIGDNSCTPPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLF8</accession>
    <name>A0A6A8FLF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000259">
        <property type="protein sequence ID" value="MRN69017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="124" mass="14869" checksum="0F00FB38B5058DEB" modified="2020-06-17" version="1">MDEEKIMFKMEKERWLIDLQKLSNDELMRMYNTLSTGRYEFAKDAWYIPLEGDKRCPIMIAKGYKAPDSPEKMVEFQETAKILEQEYRRFIDAWDFGQITKYDLEKAVLDILEARSIAIIERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLG2</accession>
    <name>A0A6A8FLG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000438">
        <property type="protein sequence ID" value="MRN69359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="77" mass="8925" checksum="CC672D4E46ED55D6" modified="2020-06-17" version="1">MTSRIIVSDTATAEGQRVYNQITDPSRDCTKCEHFQVCTIHKQIHRAISMDFNNVRQPFEIIDVAKICEHYSREIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLJ4</accession>
    <name>A0A6A8FLJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_01070</name>
        <name evidence="6" type="ORF">FIO03_01185</name>
        <name evidence="7" type="ORF">FIO04_05085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000008">
        <property type="protein sequence ID" value="MRN39626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000020">
        <property type="protein sequence ID" value="MRN60655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000278">
        <property type="protein sequence ID" value="MRN69057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN39626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN60655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="130" mass="14678" checksum="1D9875F485528A07" modified="2020-06-17" version="1">MASVELVTIEDRKNSLLNRHEMSVIFKNAAGRIKRTEATEIIAKQNNVEKKAVIPISMVCGKGKTDVRAVFYIYTDEKEAIKHLPRYRLLRTLPKEERKKIIADEKAAKLKAKQASATQSKARGQSGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLQ5</accession>
    <name>A0A6A8FLQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prohibitin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000506">
        <property type="protein sequence ID" value="MRN69463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PTHR23222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="169" mass="18194" checksum="EA62CF0B6AB0E279" modified="2020-06-17" version="1" fragment="single">IIAPTIQESVKASVAKFNAEELITKRAIAKGVIAQTIGSTLSARNIVVETVFITDFAFSQAFAGQIESKVVAFQKFLTEQNNLKAVQVIANQTVVQAEATARANVAKANGESQAIKVITVQLKQSPDYLQWLSINRWNGIMPYALASGGGSPFFQLPVTAAAQLNQTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLW8</accession>
    <name>A0A6A8FLW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000270">
        <property type="protein sequence ID" value="MRN69040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="159" mass="18036" checksum="8FD87CCB5111E413" modified="2020-06-17" version="1">MIDNKSKDDVNTTTRSTEVINLYDTARENYIRIVDELTKAQPQYTQSISNLQLDYVAAVKNTIQNMVTAQKLFATNGNVPIVTPPYTEEFVKQSNEITKNVIRAVDINNQLTISALHAAGENYRTFNRTVDSVTEFTTTAAKAWNSFLTVQQQQFLHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM35</accession>
    <name>A0A6A8FM35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000380">
        <property type="protein sequence ID" value="MRN69267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="163" mass="17489" checksum="D3C6C92AF8E91E19" modified="2020-06-17" version="1">MFSTKSLMHKNPKFAIVTTGFMAAVLTLSMLTTAIKFSSPLASALALMPGNQTSSTGGKNMTMPGGNMTFVGNMMPRKNMTMPGGNMTFGTSLQNAKMHLMEAIMDLKTGNTKGTMMELNLTAQGIKMHEQEIKSMMMGVKSMMMGMKGNATSPSTMYKNATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM49</accession>
    <name>A0A6A8FM49_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">msrB</name>
        <name evidence="4" type="ORF">FIO02_03015</name>
        <name evidence="5" type="ORF">FIO03_04470</name>
        <name evidence="6" type="ORF">FIO04_06195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WJXE01000033">
        <property type="protein sequence ID" value="MRN39999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000133">
        <property type="protein sequence ID" value="MRN61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000386">
        <property type="protein sequence ID" value="MRN69277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="3">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN61294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="127" mass="14570" checksum="0EE0959A8CB13531" modified="2020-06-17" version="1">MTTKEELKQKLSPEQYEICINKGTERPFSGKYHDYKEPGIYKCVCCGNDLFNSDTKFDSGTGWPSFWAPIKKENIKEEKDNSLFIRRIEVICSRCDAHLGHLFNDGPKPTGLRYCINSASLKHAMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FME8</accession>
    <name>A0A6A8FME8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_00075</name>
        <name evidence="2" type="ORF">FIO04_06775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000001">
        <property type="protein sequence ID" value="MRN60441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000457">
        <property type="protein sequence ID" value="MRN69387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN60441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="71" mass="8046" checksum="ADBA7F1204E596E0" modified="2020-06-17" version="1">MRLASIADSVALINRSKNNNNSEMAKFDGIKGQELLDVELGDNEITLIFKDNRFLFVRIENGRFVCESVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMH8</accession>
    <name>A0A6A8FMH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000479">
        <property type="protein sequence ID" value="MRN69417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="79" mass="8315" checksum="CA9A15A1837B7044" modified="2020-06-17" version="1" fragment="single">MKIAIVTGSGKGIGRAIALTFAKSKGYSGIVINGRKMDEVREVADEIRGEGCDSLAIEADISNENGCIRLVEEANKAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMT8</accession>
    <name>A0A6A8FMT8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000431">
        <property type="protein sequence ID" value="MRN69350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="363" mass="40081" checksum="5A6AAED1F2FEBC77" modified="2020-06-17" version="1">MDNAHSFRGKKIEPPEIFAEMTVSQLIDFFGATGYNARRLAEAGRMMAEMLRTKSTVCLTLAGAMTPIGMGKTIATMIKNGFIDWIVTTGANVYHDLHFAYGLPVRQGHFDVDDDILYSKEIVRIYDVYIKEKGTLQAQDIIVQNDLRTGNNSSASIPFAVSTADISYILGRAAKKTSSYPDKSFVVAAFENNVPIYMPAIGDSSIGLNMLPLLFEGRTELFPNVVLDVAESAAILWKSKRSGGVELGGGVPKNFFQQTGPALYQILKIKEGGQDYLIQLTDARSDTGGLSGATLQEGKSWGKIKTSHARNVTVYGDSSVYFPLLCSYVLSECKPRKLQKLYSLKNSWVEEMKKKYAETRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFN4</accession>
    <name>A0A6A8FFN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000003">
        <property type="protein sequence ID" value="MRN68101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="248" mass="28807" checksum="79B7B2BEEE1A32DA" modified="2020-06-17" version="1" fragment="single">VYSMIKEHRDNESKGTPNADLLYTLLQAQDAEAGIGRMNDSQLKDEVMTIFVAGHETTANALTWTFYLLSQHPTEEARVYEELCSVLGDKDAKRIPTVEDIPKLEYTEKVFRESMRLYPPVWTIARQAINDYKVDKYVLPAGSIILMSQYVMHHDPHHFSDPDLFYPDRWTKEAKLQIPRFSYFPFGGGIRGCVGEPFAWMEGILLIATICREWKMHHDPDHKVELKPLVTLRPKYGMSMTLERRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFX3</accession>
    <name>A0A6A8FFX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_00600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000016">
        <property type="protein sequence ID" value="MRN68181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044832">
        <property type="entry name" value="NRP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034">
        <property type="entry name" value="PTHR46034"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10539">
        <property type="entry name" value="Dev_Cell_Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00767">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DCD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="407" mass="47113" checksum="4FFB20944A6DDF8B" modified="2020-06-17" version="1">MEEIRQASSLRGYVFACTKKSQKECFDRMLFSTNKLYEDKVLGVKKGDLLFLLNIDSHVLYGAFNAKSDGRINISPEAWGGKYPFQVEVEKNGEIKSMKSAEKILSKMGISWKKALGENKTKLLLDYLEDPNGFSWRGIVPEIEATQINDKPRLEATTLWDYPRQSYGKTLKGNNKYAGVTPAFIIYNLVKRYTDPNDLVVDPMAGSGTTLDVCKEEGRMCIAYDIVSTRPDIIQNDARKIPLSNESVDMIFIDSPYGDNIDYNDHMDNIGNISSETERFYEELEKVIGESHRILKSGKVLGWLIGDQWVKKRFTPVGFNVHQRLCKYFDTVDIICVARRSQTSNTGIWYNRALRFNFYLRGFKYLFIMRKPQSTEFKPYQQYNRVINWARYSRGKQRDRTPLKPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFZ6</accession>
    <name>A0A6A8FFZ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="9">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rtcB</name>
        <name evidence="10" type="ORF">FIO04_01290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="WJXC01000040">
        <property type="protein sequence ID" value="MRN68315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="6">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="491" mass="53871" checksum="1D0D25CA74681276" modified="2020-06-17" version="1">MNELVTKIGNHKVTKINEFEFRVEMDGSKDMKVPVTIYANDDLISKMTIDRTIHQAANVSTLPGVKKHVVVLPDGHEGYGFPVGGVAATDLEEGVISPGGVGYDINCGVRLIKTSLTERDLKPRLKDLVNELFRSIPLGVGSEGRVKLTKAELDELLVEGVDWAIGRGYGREQDAEVCEEGGKMIGAEPASVSDIAKKRGAPQLGSLGSGNHFLEIQKVDKIVNERAARAMGIDEQGQLTVLIHCGSRGFGHQVCSDYLRISEIALKKYGTQLIDRELACVPNQSPEGENYRRAMYSALNFAWCNREMITHWTRKTFEKVFGMTEQQLDMKLVYDVSHNIAKVERYRINGEGMRDLVIHRKGATRAFPAGMHEIPAKYREIGQPVIIPGSMGTASWVLIGNKKSLDLSFGSTAHGAGRTMSRSAAKRSHTVEEVRTKLESRGIYVKGLTKEGIVEETPDAYKDVDAVVDVSDSLGIATKVVRLIPLGVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG45</accession>
    <name>A0A6A8FG45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000028">
        <property type="protein sequence ID" value="MRN68251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="232" mass="25863" checksum="A609D77D0F4887BA" modified="2020-06-17" version="1">MTLQFNDILLLLFRMTGFSSNWVRERKPNAPERIRESVRVQKPLKPTIDSTKNKVHLQNQKLDTTLEKLKGKEKSLFNQIIVHVQKHDMPQGKMLSNELAQVKKTIKTVSQFKMALEQVHFRLESTSDMGDVMSAVGPAMGALKRVKSGMSDVMPEIDTELGEINGVFNDIVMNAGDIGTTSFAFNVGGEETDKILAEANAVAEQRISDNFPDIPMGTFGRASRSSVNEHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG48</accession>
    <name>A0A6A8FG48_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">cobS</name>
        <name evidence="20" type="ORF">FIO04_01605</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="WJXC01000052">
        <property type="protein sequence ID" value="MRN68375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MRN68375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="258" mass="27318" checksum="297AA7708B6930F9" modified="2020-06-17" version="1">MAFRWIQAIISFLSIIPTSRHSTTFDIYSVAKVMYLFPIAGAIIGIIVGMFAYAISLYIQPLILGVLVTAVLVIITGVNHTDALADFADGLMAKGGKEGKHKAMRDPAVGSAGTVSVVLYVAGMIVALSSFHFEGLKLLTSIVVAEAIAKYTMVLQAHLGLSAWEGFSSPFTASMKDRRKMLAATAIIILILVLTGGGYAGIMSLSGSVLIGIILHYISKRSFGGISGDVIGASNELTRLSSLIIFSSATNDWSKQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG70</accession>
    <name>A0A6A8FG70_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">FIO04_01065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000032">
        <property type="protein sequence ID" value="MRN68271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="432" mass="46376" checksum="C41925B16E383603" modified="2020-06-17" version="1">MVRILITKSSINGIIRCPSSKSYSHRAIAIASLADGKSTIKNPLFSRDTLATISACKALGVVTRQDNFVVHIKGRHSFTVPENVINAENSGTTIRLMTTMSALVKSGLTILTGDESLRKRPMQPLLDSLSKLGVQAYSTKIDGTPPLIVKGGGIKGGTTDVDGSVSSQFVSSLLISCVYADSTVEIRIKGGQVSKPYIESTLATMKAFGVTVHNEGFREYHLPSASYKPTIFEVPSDLSSAALILTAGLLLGDELTITGINFGLPQADSDILDIIRTMDGRIKVNLQKGEIRVYGTERLCGGEFDLSDTPDLLPVVSVLALKARSPVRITGIGHARLKETDRVANIASQLTKLGATIKEGKNELLIIAPKNLKNASLESFNDHRLFMAFTIVAMLTKKSTVAGVESVDVSYPNFIQDVMELGGNIKPTADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGA8</accession>
    <name>A0A6A8FGA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000030">
        <property type="protein sequence ID" value="MRN68264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="188" mass="21734" checksum="6D5DBAE82EA651FE" modified="2020-06-17" version="1" fragment="single">PIYIAAGAPKTLELCATYGDGWIPIGYTPELFQRHADVIRENAKKIGRNLSDFQFANDVDIYFTDDGEEAWNKMKNAVKVSLYKPELLSVHKIQQDSEFDFRRYFTEYAMNKPELMEQMKKAALKIPDSVARTAIGVGKPDDVIQMLERFIKAGTNHFIIRFWGDGYFKNIEMFGNKIIPYFREQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGC2</accession>
    <name>A0A6A8FGC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000033">
        <property type="protein sequence ID" value="MRN68274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="275" mass="32157" checksum="0EF6002779293EE2" modified="2020-06-17" version="1">MQTAYLAYKQFNDHNPPAHHERYIFPFFAGSYFTYRKVDVMRVIAIANSISPNPNYIDIGCGYGDFLSKIRQFIPDAIGLEEDTSIFYIFQKPKPDHIYSEAAAAEWFGKRSFDVSFVGWMEPGVDFRKTVSQFTKCVITTFDAGGQCGISGGCEYDEFGFQKIAWWRTPSWIDVNCELMNRFYTSSLRTKKSKKEELTKLRTAHNLWYVYTRPEISRKVRVALKCWLKKEEHEGQYAKHRFDFESVLDECGFHYMETLAALLSKGNQLWEVRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGG8</accession>
    <name>A0A6A8FGG8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="7" type="ORF">FIO04_01340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000042">
        <property type="protein sequence ID" value="MRN68324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="210" mass="23396" checksum="CD409410FB95FD4E" modified="2020-06-17" version="1">MVYTAVLRRNRQNRTNYRKRVAMLIGRHSFVSITVSNENIMAQVLKPLAGGDSVVTAVRSRELLMYGWKGSMKSIPTCYLTGLLLGIRTLEKGMNNLILYTGKGSFTSRVAACLKGLIDAGVSIPVSEASLPKIERINGGHIAQYAEVLKKDEGKYNSHFSSLLKNGWVPENYSHYFEEVRTKITKNMRTVPDSTLSDRSKSPTRNAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGH7</accession>
    <name>A0A6A8FGH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_00055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="250"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="386" mass="40575" checksum="F727A14981018FBD" modified="2020-06-17" version="1">MPNKVCVLGAGSTKYGKLNEGIIEIALKASIDAIDSAGITPKDIQAGYISNVFGVTDRQVHMAPVIMSNLGLPEVPGLTIESACGSGSIMFREAYANVAAGFYDCILGLGVEKITHTGTIQSTTLFSYCSDFFYEGGNGASFPGLFASIARSYMAKYKASEEDLARVAVKNHENGILNPKAHVRKKITIDDVLKSPVVASPLKLYDCCPFSDGASAIILCSEDFAKKSGRPFIEVIGSGRGASPAAVQGRDDITTIPSTVAAANQAYKMAGITAKDIDFAEVHDCFTIAELIDIEDLGFFKKGAGANAVREGATSRDGEIPINPSGGLKSKGHPIGATGIGQVVEVFEQLTGKAEQRTVRDAEVALTHNFGATGASAAVHIFKRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGJ0</accession>
    <name>A0A6A8FGJ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000092">
        <property type="protein sequence ID" value="MRN68545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="81" mass="9565" checksum="A1D66FC262180421" modified="2020-06-17" version="1">MEYTPLDIIAMILETLNFKRGRILLNRFLSPDQLQNYLTVLQENRMLVYEEEKQTYKTTDKGMYFLQIYNQVGDLVAPTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGN6</accession>
    <name>A0A6A8FGN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_01830</name>
        <name evidence="2" type="ORF">FIO04_00420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000016">
        <property type="protein sequence ID" value="MRN39772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000010">
        <property type="protein sequence ID" value="MRN68146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="115" mass="13404" checksum="272692B976E37EEC" modified="2020-06-17" version="1">MTNKQVTIDEKQVTLDDWVIERFREKLKKASVIANRLGKPIVLYRKTLEESEGAGEEEVATLVNERYALVQVYTHGGFIPLSFQQQHVFSLNEFPTWMMKRSRELVLQCIEAMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGV5</accession>
    <name>A0A6A8FGV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000129">
        <property type="protein sequence ID" value="MRN68665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="194" mass="22107" checksum="7BFA200617263483" modified="2020-06-17" version="1">MLNKEDLNFSLRQILSQWPSQLTSSPPLRMAAVLVIIHYTQSSPRILLTKRNSTLKTHKGEIAFPGGAFSKQDKSLCDTATRETREEIGLIIEQKDILGSLQSVRTLTSNFVIIPFVTIQERILEPQILINEVQEVIDAPLFDLLDTEKIDLEHQAMSTKSLYEFTYGNEVIWGATARILKELHDCLYAKRDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH10</accession>
    <name>A0A6A8FH10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_07170</name>
        <name evidence="3" type="ORF">FIO04_00090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000284">
        <property type="protein sequence ID" value="MRN61810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="89" mass="9516" checksum="90A214AB0EE48EA1" modified="2020-06-17" version="1">MFIKFGAILSSVGAILLVTLAAILLVYPIVKNCHEQKCTFASSAPSPLNSFVKPAFLATSLVIIAGGVALIRFGSWYQYKSRKAENGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH38</accession>
    <name>A0A6A8FH38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ORF">FIO04_00125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="186" mass="20525" checksum="7ED673BE4150B993" modified="2020-06-17" version="1">MRLIVAITGSSGVIYGIKLLEALPKIKIETHLIISQWGERNVQIETDRSLESVKSLATRHYNNDNMAAPISSGSFKTDGMAIVPCSMKTLSSIANGYDDNLVSRAAGVCIKESRRLVIVPRETPLSKIHLQNMTRLADIGVIVLPAMPGFYHRPKSMDDLIAHIVGKILDQFGIEHNIFTRWGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH72</accession>
    <name>A0A6A8FH72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aconitate hydratase</fullName>
            <ecNumber evidence="9">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_00450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="WJXC01000011">
        <property type="protein sequence ID" value="MRN68152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="8">
        <location>
            <begin position="566"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="763" mass="83706" checksum="9FAF602E31FD1CC2" modified="2020-06-17" version="1">MNNHLATIPALVSAVYKKSQANVLEFRKIVNRPLTLSEKILIGHLVSIDKTEPGSGTSYIFLQPDRVALQDVTGQMTILQFMQAGLKRTVLPTTVHCDHLIQARVEGKSDTKAAIYENHEVYQFLESASRKYGIGFWKPGAGIIHQVVLENYAFPGGLMIGTDSHTPNAGGLGMIAIGVGGLDAAETMAGMPWELLYPKRIGVYLSGKLSGWTAPKDIILYVASKLTVSGGTNAIIEYFGPGSKSISCTGKATITNMGAEIGATCSIFPYDQRMEAYLRATGRGSVADLANEHIELLTEDCEIETEIEKNPKKYFDRLIKINLSELEPYIVGPHTPDLARPISQMAEDVKKNKYLDSISVALIGSCTNSSYEDMSRASSIADQAKSKGVKIKVPLLVTPGSEMVRATIERDGQMESMKTIGATVLANACGPCIGQWNRPELRRGEPNTILTSFNRNFPGRNDGRRETMNFIGSPEVVLALALAGRLSFNPLDSELTADDGTKFKLDPPRIAPEIPTNGFEEVTDVYLSPSDDPDRIAVVIKNDSSRLQKLEPFTKWDGKDFENLPILAKVKGKCTTDHISPAGPWLMYRGHLDKISDNMLLGAVNAYTGGVGIGKNSLSGNTKSFPQIAREYKEKGVKWIIVGDQNYGEGSSREHAAMTPRYLGCVAVIVKSFARIHETNLKKQGVLALTFENADDYDKMMDGDRISILGLQDLQPGKPVKCYLQHSDGTREDINLHHSYNKSQIEWFHAGSALNILRLKENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHC9</accession>
    <name>A0A6A8FHC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000022">
        <property type="protein sequence ID" value="MRN68212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M17_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="190" mass="20934" checksum="BE616733600981E2" modified="2020-06-17" version="1" fragment="single">MVGVIVQEAKIDQMQTALLVIGIFENERDFFKSKGLDSTITAAIIELIENKEFKRSFGSNIIFHMMGKGLIKKIMLIGLGTREKFTDEEARIIAGKAALKAKELGVEEFCILPFMDVDEALIEAISEGVLLSLYSFNRYKTSGKEATTIPAQATIVVNSDSAKFQAVVDIVNLITQAVNYARDLSNLPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHD9</accession>
    <name>A0A6A8FHD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000020">
        <property type="protein sequence ID" value="MRN68198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="52" mass="5448" checksum="31B08DA7D3467273" modified="2020-06-17" version="1">MLSVIGSENAMLSPPENSTLKSVTVTALTADHGLSVTKDYRTPLKIPGMMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHE1</accession>
    <name>A0A6A8FHE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium-transporting ATPase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000199">
        <property type="protein sequence ID" value="MRN68875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="224" mass="24776" checksum="E7BB36A54BCD322C" modified="2020-06-17" version="1" fragment="single">MGIIMRMREKFKYSTNKNNGSSFTKDLSNINRKQVILGSLTKLNPYYLAKNNAVMFTVEVGFVLVFAIGLALPTIPKEFASQTPIFYYEVAVILIVTVWFATFSEALSEAQAKARVDSLRSLEREVSARKLVGEGKKELIVASTSLKPGDEVLCYAGETIPRDGLVCEGKAFVDESMMTGESNPVFKDKDDHVIGGTRIASDKLRIEITAEVGRSFLDEMVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHI4</accession>
    <name>A0A6A8FHI4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="5 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="14" type="ORF">FIO04_01070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="5 10"/>
    <dbReference type="EMBL" id="WJXC01000032">
        <property type="protein sequence ID" value="MRN68272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00370">
        <property type="entry name" value="Shik_kinase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="PTHR20861:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005758">
        <property type="entry name" value="Shikimt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="76"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="206"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MRN68272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="284" mass="30099" checksum="3642532F003DBAC3" modified="2020-06-17" version="1">MIKKRVRATVHGAISIVNALATCSGCALGISLRVTAEADLRSGEGIRSQTVNEKLIRNIVYNTIPKEILAENSVYISVESEIPMGFGLKSSSAVSDAVALACSKLVKEDIEDYVVLDRAVLASLDAGVTITGAYDDSSACYFGGFVVTNNRTHEIIHHQEAPQNLSAIIFIPKGTRRGNMSKVDTMSNLFGEAFKFATAGEYWKAMNLNGMLLSTSLSAEYEPVLKAIQGGALAASISGNGPAIAAVSNEENMEDIKAAFAKFNGSVIVSKINNEKATAETLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHJ9</accession>
    <name>A0A6A8FHJ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000029">
        <property type="protein sequence ID" value="MRN68258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="174" mass="20391" checksum="32474E65CECF9252" modified="2020-06-17" version="1">MVIFYDDKVDYCRVTTDDSEISPMIRTTKSEFETIRANSGWLELEDKQEQKQMKGLVKLYKVRGQSFGVCAVYCGDNVQWTKMIEDVPQNWSTTLRTIFEDQWSGNLEEDINTAFPMFDGNIEYHNNSSYIPQNLVQSFPVIYILFNFVYNEMSRCVFEQIIKYVDLVELPPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHL6</accession>
    <name>A0A6A8FHL6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine radical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_03335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000145">
        <property type="protein sequence ID" value="MRN68714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="464" mass="52148" checksum="862117B19221D901" modified="2020-06-17" version="1">MQRTLTTPEKTTQLLVRINGTLPNISTMDDEQKSERAAEIKRKEIIANTSCSIFGTSPPAADSSGANTNFHLLVDVGEGVVESLEKSGTDVTSAQSKIIISDIPNAVLITHSHDDQIKDLPKLFNKVVDGSDKVSVYCTKECCDQIMSKFPQLAERRSAFNIIEPNKPFTTGPFTVVPVVANHGDNSTPSSVIYVVKYQDKKIIMGWDFLSLPNADENLLWNPDLLVLGTHTYNPHPESGMISVIEAYELVRRWNAKESYLVQYSGLLDFKESKNEWFKGPSKAMTTAELQRNIDSHLKVSGDNGRFRITVANEGMLWAAKEDSHLHEEENNKDPIGRVIEVEGLQKYTFKIEKDSKVDKLRVIIEDRINRYSMQFDRPHKDKGNEFIIRGEGEQGTFSKGPALRMELVHSESKGTPSALKILADKGNILKGKKDVFHDDILVSDFDANRLKKYFQENFVARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHQ6</accession>
    <name>A0A6A8FHQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF111 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000164">
        <property type="protein sequence ID" value="MRN68771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="12000" checksum="988BA0B63C3F7038" modified="2020-06-17" version="1" fragment="single">PTHLIRIICDHANLNNVLTTLFRETGTIGARFQEIQRLILPRSIVTVPVNISGYDFNVRVKISRGLNAEALGVKPEFDDVKVIASTTGISVKRALELVSAQITYKINVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHS5</accession>
    <name>A0A6A8FHS5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000171">
        <property type="protein sequence ID" value="MRN68794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="2">
        <location>
            <begin position="16"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="287" mass="32335" checksum="34FB84E052CAC381" modified="2020-06-17" version="1">MASRLEKNDFELETVLVLQGGGSLGAYECGVYKALARYVKKFDIVAGTSIGAINAAIITATIQDENPSRKLEDFWLELAQSIGSPIPLLLSDKTRRIMSTIFAATWGNPKAFIPKWLEPESFTYPAFGLPYPLFDISPLKETLSKYVDFEQLRKREDSNPSTPRLIVTSTDLKTSEAVVFDSNLIDIDVDHIIGCIGFPFYGIGWNQKDGRYLWDGSLLSNTPLVEVINSSPVSDKKVYIVNLFPRYQEEIPNDMLEAWHRARDIMYTDRTDSNVRTSKIPRTCMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHZ5</accession>
    <name>A0A6A8FHZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_02735</name>
        <name evidence="2" type="ORF">FIO04_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000029">
        <property type="protein sequence ID" value="MRN39944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000016">
        <property type="protein sequence ID" value="MRN68179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="468" mass="53019" checksum="9874455F640AC807" modified="2020-06-17" version="1">MMSENFWRLVEEYQQLGFDPLRWIPTCSNEVDNYILQDSLKEVKRSNIKLTPSWFDTFYYTEGKIPELTRRVYNFENPVIEKEVEIKRALSIFRIHTVIGYDPALLSGAVQKFFNSFHSKVCIRKNTMVLTTRREAQFALLDYIELHRGDKVGYTSANNSVTQITDPTQRPESEIHSNIALTAGMENLNLLGCTLGFKLFPVYDAPTEQMLDKIRINLDSFTSRYNIAMEDYSSIKIGNLFFGTTAIANTVKELPTRYDQVEEGMQIILSNKMGAMPALSLYMLTQMDHNNIVKFEQNGISLDVLSAAKDETIKSLSEPHFSLGKVISKYCPDFGMAYDKNTNITAVHPVTTEGFFAIGKLAELTNSHIVINELPMKYEEIGKFATKELLIENATASSNGCHLIVATKDVASLVVEDLRKHNFEPTIIGFFAKKERPAVTTEKDITQYIASKSKLARLNSLAQTEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI21</accession>
    <name>A0A6A8FI21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000115">
        <property type="protein sequence ID" value="MRN68616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="213" mass="24627" checksum="BAF7B7BD3A2386B9" modified="2020-06-17" version="1" fragment="single">MSSVDQNPVHDLESLNWDDLLSLKRSQLNQIKDLTDKIIDIEKNRFRLINENIQQEKNKLVNMTTRLAQIRTEMNSNNSQLLTISEKISKSKNFVSIMGTRLPSDNEVDLVRILESSQKLVDEKRYKNERQKNEALSVMNDASMKLEAIKAIRTVNEQLIDLNAQAEEIKKILKILENEVTTLQTKIADTHNKIDKLFVSKRQQAAEHQSCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI32</accession>
    <name>A0A6A8FI32_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpsI</name>
        <name evidence="7" type="ORF">FIO02_01565</name>
        <name evidence="8" type="ORF">FIO03_06950</name>
        <name evidence="9" type="ORF">FIO04_04245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000014">
        <property type="protein sequence ID" value="MRN39723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000271">
        <property type="protein sequence ID" value="MRN61768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000204">
        <property type="protein sequence ID" value="MRN68891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN39723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN61768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="149" mass="16347" checksum="E187A96CF7D925D8" modified="2020-06-17" version="1">MVVSKTDLYPGQRKTCRAVATISKGNGRVRINNIPAELIEPQIAKELVLTPLNLLGELRNKVDISVKVQGGGFMGQAFASAVAISRALTGEGKGGRDPKDHPLTKSVREEIRKKIAEYDRHLLAGDPRQSESKKFGGPGARRRKQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI35</accession>
    <name>A0A6A8FI35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_01980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000068">
        <property type="protein sequence ID" value="MRN68448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="49"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="558" mass="59529" checksum="68E8BD01684A91B5" modified="2020-06-17" version="1">MQVIVMDDLKKDERTPDSEAPKKLPQPLSSSKAVVPETSEKIRTSAWITLAILGSTVLITMYGETMLLPAIRDIIRDFDISYTTSSWILTAYLISGAVSTPIVGKLSDIYGRKKMVVIILIIYIIGISAGGVSTNISFLLIARVIQGIGISVFPIAFGIIRDQLPKEKLAIGVGVFSSMFAAGSVVGLAVGGTIINNFGWHATFLSIVPVAIILWVIINRFIHGDNNRAETVEKEDNLAQADANADTESSIVHSPKPGRVGFNSNGMRSLDVKGAITLAVTIASFLLTLTYIGNSSSSSNISAYPTQIILVSLALLSTASLVLFVIIERRAASPLIELSLMTHKILLPANLLILIFGITMLMVYQTTPILVRSPQPLGFGGDAVASATVQLPFMIVILVFAPSSGFIVSKIGNLKPTVAGTIIMTVGFFSLFIFHSTEFMVAINLAIVAAGISLIQVGAFNITMEYTPLRFSGVSLGMSVVLVLIGSSIGPAIAAIYMQTHQELAKGVGSGSFPSPVSYNLIFLTAALISVISVSIVMILKRRMTQSSLKKSEMEATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI64</accession>
    <name>A0A6A8FI64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA pseudouridine(13) synthase TruD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truD</name>
        <name evidence="4" type="ORF">FIO04_05480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000314">
        <property type="protein sequence ID" value="MRN69135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="245" mass="27923" checksum="3D3CC97F293E617C" modified="2020-06-17" version="1" fragment="single">RSVTHLVGREIVRRNFKNAVELLLCYTSEYDSKTSREIREKSRDPHNYPRLLKLLPRGMDIECQLMSAILQGKDVIHALRVIPINMRRLFVQAYQAYIFNISLSTAIRNGENLLKGKEGDLCFEIGGPLIFGKIRKFNSISDSEANAVPAIKLAGYSFQAGKGRFELITKDTMQDEGVVARDFYIKEMQELSSQGGFRQAPLWCRDFSVIDKTMLTLSFRLPKGSYATTLLRELMKPFDPIKSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI99</accession>
    <name>A0A6A8FI99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000085">
        <property type="protein sequence ID" value="MRN68518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="595" mass="65427" checksum="9F3D78903FD547D0" modified="2020-06-17" version="1">MVNAQPITLKDMVTYEKQSNFIKEFKIPLTERGLKGITTDTLGNAWFYHSTFNSSTIVRLEPIVMKFTQYSVPGKTVVDNAIINLAGGQLVFDNDSNVVWFTDARTNSIGKLDVKSGDIQLVSIPTPKAGPMGIVLSPDGKSVWFAEITGNRIANLDIQSNKIIEYPVIGSASSSNNNGILNNQDNGPTFLTFDSKGVLWVTLSYSSSVLRVEPWALVPNSSTMGMSPFTLAKSETFSPFGIAVVDYKAGSQQRMYVSDHGSSRIISTDAGPNLLLQSYLSYWTSPSQVYPTTLPGQIVADKLGKAIYFPEHGGNRIAKINVDSGQMTEYDIPTGPLSTALFTAISGDGKKVWFTEWASNKIAYLDTTIPVPLTIQVPGYYNINNNNNNNNTTMLLVLKRNAPKILDVVLKTDNNNKTALEASSPSTPQSLLLNEVGLSLVGMGESGIAGINYTAQPQRIDMEKNSTANSQIALQVENDENNSRIIRTGQYTIMVRATALENKDNNSLVSLLYPVQIMLDVPAPPINQQQPQQTYPNNISNNYQVPVNGFFDFTSLGGILRIFPLLVAIGLIAYIVYRRIERSRKTTQQHRPQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE2</accession>
    <name>A0A6A8FIE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_02020</name>
        <name evidence="2" type="ORF">FIO03_07015</name>
        <name evidence="3" type="ORF">FIO04_01315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000019">
        <property type="protein sequence ID" value="MRN39807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000274">
        <property type="protein sequence ID" value="MRN61780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000041">
        <property type="protein sequence ID" value="MRN68319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="85" mass="9789" checksum="195AE4D89F76A532" modified="2020-06-17" version="1">MKQVQLLRLLVRERAIVRLLKTIGYSEYPTRELLQRLGAYGYGHKLLLKAQRNGLVQRKVVKNKVYNKLTGDGKKLIKLAKEIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIF3</accession>
    <name>A0A6A8FIF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.49</ecNumber>
            <ecNumber evidence="2">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiD</name>
        <name evidence="2" type="ORF">FIO04_02650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="2"/>
    <dbReference type="EC" id="2.7.4.7" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000103">
        <property type="protein sequence ID" value="MRN68578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="445" mass="48577" checksum="0BE2F6FBD7DC8B31" modified="2020-06-17" version="1">MKVALSIAGSDSGAGAGIQADLKTFTSLGVYGCTAITAVTAQNTQEVSSVFEVTPECITEQIRSVILDMPPDAIKIGMVYNKPNIETIRRVLKGSKVPVVLDPILSAGTGGKLLLPEAFESFKADLIPLSTIITPNRIEAQKITGIQIISRSDIARAARKIKNLGAKNVIIKGNHFEKKQVADILLTSEGRLIEVSNSKLSSEEMHGTGCNFSAAITAFLARNFSIIDAFKLANKYVRDSLQNALKIGKGLLVSNPASSMYDYASRYVVLKGLQWAIEDIETSDNFGILLPETQSNIAFALPDARELDHIAAIKGRIIKIGDTARSASSMVEFGASKHVGSALLAYMTVNRLVRSAMNIKYDEKIRKITKAVFKVSNYDRSKEPRHILKKEGMSIFWGIKYALAKNPEAEIIYHEGAIGKEPMCIIFASNPAEVVNKIRIILKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FII5</accession>
    <name>A0A6A8FII5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000112">
        <property type="protein sequence ID" value="MRN68608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="95" mass="10048" checksum="3D4D016EA3A6BC6E" modified="2020-06-17" version="1" fragment="single">MTMLLFSLWIDISWIDTTYAAALPNKAEVKITSPSKGQQVQPGGILVSGTSSANATTDCTVSVVINGIRPYQRAVPTGHGGANDYSNWTFTATQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK4</accession>
    <name>A0A6A8FIK4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="3">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">panB</name>
        <name evidence="7" type="ORF">FIO04_01125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3 6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000034">
        <property type="protein sequence ID" value="MRN68283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="3 5">
        <location>
            <begin position="60"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5 6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="296" mass="32270" checksum="9C5E0E3CA469FFF2" modified="2020-06-17" version="1">MQRHYQKNCNHTNTLVRRNNVNDILTLKKKGEKIAALTSYDYSTSLICDKAGVDIILVGDSAGMVMLGYKSTMPVGIKEMLVFCKGVAMGTKRAMVVADLPFGSYQPSVGAAIKNAIRFIKVGCDAVKLEGGTEVVDTIKALVSMGIPVMGHIGLKPQTSSLWEGYKVQGKTKNSSQKLITEARALEQAGVFSIVLEMVTSEVASIISQDLSVAVIGIGSGSGCDGQVLVLHDMLGIYEDIKPKFVKRYADLSNSIFQAVSLYRSDVKSAKFPEEENVFHMNSNEYRELQKNTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK6</accession>
    <name>A0A6A8FIK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000113">
        <property type="protein sequence ID" value="MRN68612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="72" mass="7448" checksum="5AF85E67CC2B24E4" modified="2020-06-17" version="1">MNGKPFRSMTAVNKSLEVLAGVLREITISILGDSNDFAIESASGSWFESLLIPGVAGFLVGGPLGAVGRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIL1</accession>
    <name>A0A6A8FIL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000298">
        <property type="protein sequence ID" value="MRN69104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="173" mass="19756" checksum="C5A5E80C60566951" modified="2020-06-17" version="1" fragment="single">SEFLRQKGHNTTVVVFGSLMFEESKEMKLRNRDEMRKLSVEEQRRLQDKVANRIATIKGDFVIIDTHLLINTDEGYYPGIPMHLLETIKPTNIIMIAADPQEILNRRKKDESRKRDIRPEIDVQNELDISRVMIACCSVVSGCPFLTIMNNNNEIDKAALTLANVLLGDTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIL7</accession>
    <name>A0A6A8FIL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000385">
        <property type="protein sequence ID" value="MRN69275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="228" mass="26606" checksum="6600EBC15063B334" modified="2020-06-17" version="1" fragment="single">FKDCRWSNNPRHDKKECRRNRSRDRDASWTWDHHREKYVYGYKVHVVIDSDSGLPVMLTITKAGYGENRTVSWFIKMVLLNLPLIKIRKLLADAGYDGDKTRLQIVKRLKAVPFIPLNTRRSKGSTPEEKKARRKVLCYLFYARNFIKNYWVDPDSEEFDKEFDARTLSEQGFSIGKGSLNLDSLKHRGIEWATLHSMCICMVMLLVAKTAIEIGRPDLTRCVKCFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM4</accession>
    <name>A0A6A8FIM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_02920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000120">
        <property type="protein sequence ID" value="MRN68632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="6">
        <location>
            <begin position="42"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="7">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="194" mass="21739" checksum="EA111F21003DE5CF" modified="2020-06-17" version="1" fragment="single">MKSISNIISQALKQSQPSAEDVEKLTKIAIETKSLVSRYISPKVVDVVFGGSFAKGTWLKDEVDIDIFIKIDNSVNDKEFGQLGEQVGLQSLKGYNPYLRYSDHPYVEAVINGIRVNVVPCYDVLKGKWKSAADRSPFHTEYIKNNLDDEQRNQVRLLKKFLKSVGIYGADIATGGFSGYVAEIMILKYGMFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM5</accession>
    <name>A0A6A8FIM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Excinuclease ABC subunit UvrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">uvrC</name>
        <name evidence="9" type="ORF">FIO04_03000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000124">
        <property type="protein sequence ID" value="MRN68648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="6">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="8">
        <location>
            <begin position="360"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="521" mass="60036" checksum="DF6A51663772918A" modified="2020-06-17" version="1" fragment="single">MKDSSGSIIYIGKAKNLQKRVSSYFSKQSAAISENIPRQNDNWKTSRLVGKIHDIDFILTDNEIEAFLLESNLIKRYRPVFNIELKDQQRYTYLKITDETFPRLLVARRNRKGDIYGPKGKVYGPFVRGSSKFLAVGLLRKLFKIRICDKLPKKPCLEYFLKNCDAPCINNVTRDEYKKNVDTLHSILRGKSNIDKFVNEMEAEMKRAAEIQDYEKAQQIRDTLRRLNNLSAKQKMEKFLRRNLDEEYVGIIKEIETAVAHVMTLRRTKGVITDRKKFDFELIGDNSLATFLSQYYSTVLEIPRFVYVNEMPVSRETLEASIERFTDHEVNIILVSDDFQLKEKKDLMDLVTRNLKLHVEKGHAPGIVELKNILHLPIIPSVIDCFDISNFGNTYAVGACTRFVDGKPYKDGYRKFKIRLTFNQNDFAMIQEIVTRRYSPIQTENYPRGRAQPLPDLIVIDGGKGQLHCAIDALHKAGLEVPCISLAKENEEIYSPDSTQPILLSRNSAALKVIQHIRDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ2</accession>
    <name>A0A6A8FIQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_01130</name>
        <name evidence="3" type="ORF">FIO04_01385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000008">
        <property type="protein sequence ID" value="MRN39637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000044">
        <property type="protein sequence ID" value="MRN68333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="49" mass="5246" checksum="8807F50FC844E630" modified="2020-06-17" version="1">MRNQRRIGEALMIASGIGITVVGYVLGVFFVSYGGLAIASLGVVSIFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ5</accession>
    <name>A0A6A8FIQ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="2">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_01435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000045">
        <property type="protein sequence ID" value="MRN68343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="34"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="223" mass="23739" checksum="1DF62FC6566C0044" modified="2020-06-17" version="1" fragment="single">MLCLGIESTAHTFGCSIIESSGSDSMLRGRIVSDSRDVYKPPEGSGIHPRDASRHHCQISDKVFRNSLTAAKLSIKDIDVISYSAGPGLGPCLRVGAVIARTLAAFHDKPLVPVNHAVGHVELGAMLTGAGDPLVLLVSGGHTMILAFSEHRWRIFGETLDITIGQLLDQFGRHIGFSSPCGDRIEQLACQSSGEYQSLPYVVKGNDVSFSGLLTAAIRAVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS1</accession>
    <name>A0A6A8FIS1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO03_03025</name>
        <name evidence="4" type="ORF">FIO04_01935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000077">
        <property type="protein sequence ID" value="MRN61018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000065">
        <property type="protein sequence ID" value="MRN68439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="163" mass="19567" checksum="E39FEA7B550B04C9" modified="2020-06-17" version="1">MTQKPCIRKSLSFEGEQQKIGHNGSRKKFSAYISMVWHDQKLMTYDFYDKMNSTNTINHLENLYVHIMKTGWKRLILIWDNASYHVSQIVQNYINAQKDWLTIIHLPKKAPYLNPNERRVNQQIKSDVCANRFYDHIEKLKDAVSEYLDTRFGRYYYDIIHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIT2</accession>
    <name>A0A6A8FIT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_11025</name>
        <name evidence="3" type="ORF">FIO04_06505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000317">
        <property type="protein sequence ID" value="MRN41561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000421">
        <property type="protein sequence ID" value="MRN69335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="122" mass="13599" checksum="9BE3553F9FD35BA3" modified="2020-06-17" version="1">MKVLIVDDNEELTDAVKDFLDSIGIECKVKNDGKEGLNEILTERGRYNLILLDMAMPQFSGYDVLDTLKTQGLLKSEQIVIFTASSITAKSIDDFLAAGAKEVLKKPVSLDELSQLIERYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIU1</accession>
    <name>A0A6A8FIU1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="7" type="ORF">FIO02_06790</name>
        <name evidence="8" type="ORF">FIO03_04810</name>
        <name evidence="9" type="ORF">FIO04_01645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000119">
        <property type="protein sequence ID" value="MRN40730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000149">
        <property type="protein sequence ID" value="MRN61362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000053">
        <property type="protein sequence ID" value="MRN68383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="6">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN40730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN61362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="103" mass="11661" checksum="3E4FD1C62015422C" modified="2020-06-17" version="1">MPQEARIKLTSTNLSTLEGVCTEIKGIGEKNGIRLKGPHPLPTKKMKVVTRKSPCGQGTNTYDKYELRIHRRVIDLGADDRSIRQLMRLKIPDDVYIEVSLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIU7</accession>
    <name>A0A6A8FIU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_06605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000435">
        <property type="protein sequence ID" value="MRN69355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="237" mass="25475" checksum="CAE02B7198AEE603" modified="2020-06-17" version="1" fragment="single">MQIAFNSRHSTATYREEKGRTSLALSQLVLLQSRKRWGVMYMLATVSGLFVPIAGVFPSIEDHGVNSFLTTLLLKSAPLLAATFLIITGMYVLNDLVDADLDKSSGKKRPISSGQVTKAQAHIFVIATNAAGIFLALITFNLPSIIIALAIVGIGLMYSVPKICLKDRFVLKTASIAAASMLCLMLGSSYAFNNSGMIHNNNNNNNNNYNYIGGALSSPILICTYAALMSGSIIFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW5</accession>
    <name>A0A6A8FIW5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000456">
        <property type="protein sequence ID" value="MRN69385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="162" mass="18188" checksum="7EEAB1334BAC0BF3" modified="2020-06-17" version="1" fragment="single">PKHFFSEGDSVDKITPETFIREAVILDMSYKETGQGITDADLDSYSNSVNARDIILIYTGYDPLQEQNNSWKNFSYLEASAARWIVNRKVKCLGIDTFSVEKYGFDEGTVHKTLLAKEIGIIEGLSQELKNFVGKRMFLVCLPLLLKGIDGSPARAILFDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ25</accession>
    <name>A0A6A8FJ25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000091">
        <property type="protein sequence ID" value="MRN68539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="264" mass="30828" checksum="9E9BAFB3A94F2BDB" modified="2020-06-17" version="1">MIIDCHVHLNQYGYATKIPLEERLQSLLDTMDNYDVDYSLILTSYKVTSDRPSTSKIIEITKKHDNLGVVAGFSIDNHSDEDLQNCRRWFKKGFIKAIKLYCGYEHYYPYDKRYQRVYDLCVEFNAPVMIHTGDTFLKEGKLRFSHPINIDDVAVDNPDLKIVMCHLGNPWIIDCQEVLYKNKNVYADISGLFFGDFTPASEKYLGKKIKELLNYAGEPRYLLYGTDWPISDMGVYFNFFQKIKLNSQERDLIMFKNAKVLFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ27</accession>
    <name>A0A6A8FJ27_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FMN_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_03870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000178">
        <property type="protein sequence ID" value="MRN68818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="7">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="152" mass="16351" checksum="573955580046D1B6" modified="2020-06-17" version="1">MRLVLVGVSAINVAGTGGTSWAGVEKLRAETQKDKVKIRLGELFWDWGIPTAASLIEVRQAVPQVPLIASGGLRNGLEVAKCIALGADMCGMAYPFLRKAAESKESLFEFAKMITEELKSAMFLVGAKNIKDLKSSRYILTGYLADGASSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ39</accession>
    <name>A0A6A8FJ39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_04980</name>
        <name evidence="2" type="ORF">FIO04_03920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000158">
        <property type="protein sequence ID" value="MRN61394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000182">
        <property type="protein sequence ID" value="MRN68828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="108" mass="12645" checksum="F5D565326AED8A41" modified="2020-06-17" version="1">MTATYTCEKTFELKEGSEVLEGYTQIMCTDCTFNALMLMDVHALIRYQDRETNKILQRQKEIDSQVHDIMLKEKEGEEEINNSTLSLAQKQLRQLNRESYELIDLLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ56</accession>
    <name>A0A6A8FJ56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000099">
        <property type="protein sequence ID" value="MRN68569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6261" checksum="211370470F4E7EE6" modified="2020-06-17" version="1">MISEHTIVEMEILHTPLSGGKGLSSLLKNRMEIRDGDKKSSVPGQQHTQFRMVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ76</accession>
    <name>A0A6A8FJ76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000526">
        <property type="protein sequence ID" value="MRN69495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="197" mass="21782" checksum="4B29AA5C239902CC" modified="2020-06-17" version="1" fragment="single">MNGEDQYLARIYQRFPVNIARGKGAIVWDTSDREYIDCMGGYGVAIVGHCNDRVVRAIRTQVEKLIVCHMSLYNDTRLRFLQKLATIAPPGLDKTFFSNSGAEAVEAALKFSRKFTGKKGVIAMNGAYHGKTFGALSVTHNEKYRKSFQPLLEGVKFVPYADPNKVEDAIDETIGTVILEPIQGETGIIIPPDGVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ86</accession>
    <name>A0A6A8FJ86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_06330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000402">
        <property type="protein sequence ID" value="MRN69301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="74" mass="7458" checksum="C4CCA13393B821BB" modified="2020-06-17" version="1" fragment="single">YATLSGTSVAAPFVTGAAALYHSLHPTASPAQVRSALVSLGSTASTVCNGDGHGYFNNPHGNEPLLYIGSFAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ90</accession>
    <name>A0A6A8FJ90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000092">
        <property type="protein sequence ID" value="MRN68543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="103" mass="11731" checksum="CAFBBFC5432CA30D" modified="2020-06-17" version="1">MERDEIIKRIDILTRGLSQRSSDINESSEIKILRSEVEEEDKPKLAALLEDLIVLLKDDPENRGKIKGIWNRLMDGYGHIKPILELLGSVKLSFLDSTTNNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ97</accession>
    <name>A0A6A8FJ97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000112">
        <property type="protein sequence ID" value="MRN68609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="212" mass="23310" checksum="80EABDAD351191A9" modified="2020-06-17" version="1">MAITEILTSLVQFITSIISNLGYGGIFFLMILESALIPIPSEVIMPFSGFLVSVGKLGSVGVVLAGSFGNLVGSIATYYLGLRVGRAAIIKYGKYVLFKKKHLEYTERLFEKYGDKIAFIGRLLPGVRTYISLPAGIGLTGIVKFAVYTFAGSLIWNALLTYAGIELGINWKHIDKYSGYLYTTAIVSTIAIILWILYNRRRGNKSKTTTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC4</accession>
    <name>A0A6A8FJC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-sensing transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000258">
        <property type="protein sequence ID" value="MRN69016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="36" mass="4198" checksum="40B40D926D0CF107" modified="2020-06-17" version="1">MRLARIEGHVKAIRKMIAADRNHSDITHRFLLSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE1</accession>
    <name>A0A6A8FJE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_11410</name>
        <name evidence="2" type="ORF">FIO04_04485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000345">
        <property type="protein sequence ID" value="MRN41632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000225">
        <property type="protein sequence ID" value="MRN68938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="83" mass="9260" checksum="C2AAF18B16E92456" modified="2020-06-17" version="1">MSQISTDKTTQETSKQWAEIAGQIIDKLIGKNMSMTYDFQKLTIDIPKAEGPGGKHMGSVQWTINGKIIITSEAYDKNNQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG0</accession>
    <name>A0A6A8FJG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000445">
        <property type="protein sequence ID" value="MRN69371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="268" mass="28886" checksum="5558D6172B08D7C4" modified="2020-06-17" version="1">MYCDISDVIQTPKLLADKVALVTGSTKGIGFSISKEFAENSGATVIVCSRNEEQADRAIKQINGKVFAAALDVTDNSSVQKFMQQILSVHDRIDILVNNAGYPFDREIWYKRFHEVTDEEQEKIIEVDLKGSVRLSKAVIRSMLQNVLNRNGGVIINISSTPAIAGHIEGSPYTIAKAGNIALTKCIAMEYGSSNIRAYTLALGNIATLATCGSMTEYDRAKAAAEPSMKRWGKPEEVAKVAACVASDNFSFATGNTIIIDGGTVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJI4</accession>
    <name>A0A6A8FJI4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpl37e</name>
        <name evidence="10" type="ORF">FIO02_00465</name>
        <name evidence="11" type="ORF">FIO03_06650</name>
        <name evidence="12" type="ORF">FIO04_07015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum02</strain>
            <strain evidence="11">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000003">
        <property type="protein sequence ID" value="MRN39507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000251">
        <property type="protein sequence ID" value="MRN61708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000489">
        <property type="protein sequence ID" value="MRN69434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN39507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN61708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN69434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="56" mass="6687" checksum="B860B1995B025B62" modified="2020-06-17" version="1">MTKGTTSMGNFTRKKTHIRCRRCGHNSFHKRGKECAKCGFPDARMRKYNWIKRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJI8</accession>
    <name>A0A6A8FJI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000140">
        <property type="protein sequence ID" value="MRN68699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="114" mass="12606" checksum="FBB593FD01D09E82" modified="2020-06-17" version="1">MKRCAAIGHALAMNPKVLLMDEPFSALDIQIYQDRTIWFLTHKINDAMALGGVIVVLSPKLAGIKRECTVGLPRPPDHPIVDSNAMAVTEESKELYFDDETGEDNKIAATKVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJK8</accession>
    <name>A0A6A8FJK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF126 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000299">
        <property type="protein sequence ID" value="MRN69106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="11173" checksum="A409DFD34409D54F" modified="2020-06-17" version="1">MIDTEKGIIEDPHHQLSGSSVKGAVLVFPGAIGSSVGAYVIYSLKVNGAAPAAIISTNKADITTASGCAISNIPLVDTLDTGSSFAMRSGMEVKVDADSKIVCVTNRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM5</accession>
    <name>A0A6A8FJM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000131">
        <property type="protein sequence ID" value="MRN68673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="80" mass="9326" checksum="F838BA7E24E33D1B" modified="2020-06-17" version="1">MMLLWREAWIKPLSEYDLGSEKCAYCKERFNDLDFVTSCEFCEIGIMHDLCANTHINTHHGNQVNAKVAAHKDKPLHDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM7</accession>
    <name>A0A6A8FJM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000310">
        <property type="protein sequence ID" value="MRN69126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="117" mass="12859" checksum="69B47BA06C886139" modified="2020-06-17" version="1">MNIQPVYATGHGDDKQNIADIFVFGSGIFAAFLFALSLLAYRNLLTKRLLLVSAAFGIFAIHAIVSKLDLFTPLHIESSVLELILAIMNFVALAFIFLAIVKRAKIKTKTPTPRSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ7</accession>
    <name>A0A6A8FJQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_05980</name>
        <name evidence="4" type="ORF">FIO03_04210</name>
        <name evidence="5" type="ORF">FIO04_07155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000096">
        <property type="protein sequence ID" value="MRN40575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000123">
        <property type="protein sequence ID" value="MRN61245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000505">
        <property type="protein sequence ID" value="MRN69461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="PTHR11021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN40575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN61245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="84" mass="9518" checksum="CDA1F529BD920D0C" modified="2020-06-17" version="1">MSSSPSSQQPKRPLSTLQRAVNRKVAVRLKSEIEYRGRMSNVDSYMNLILVNAEEFDGADVLANYGKVVIRGNNVLFIKLEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS5</accession>
    <name>A0A6A8FJS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000170">
        <property type="protein sequence ID" value="MRN68789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="94" mass="10686" checksum="4AA4A26602351B04" modified="2020-06-17" version="1">MFVHKSVSVGWPYVSSQNCRACEVVSWVGSSEKGWENAAQTAVREEAKTIHGIRGIEVKEIAAKIEGKTRKIQEFRGGIKLAFGVERKYWRYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS9</accession>
    <name>A0A6A8FJS9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,5-diamino-6-(Ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000517">
        <property type="protein sequence ID" value="MRN69481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="147" mass="15945" checksum="61E6188AA2E07898" modified="2020-06-17" version="1" fragment="single">MRITINAAMTVDGKIATTCGNSRISSKQDLIRVHELRSSVDAIIVGISTVLIDDPLLTVRLIRSNKGKDPARVVVDSDGRIPLDSRILKTAHRVATIVVVSERAHDNKIHKLRSTGAIVIIAGRVMVDLGEALSCLKKMGFKNILAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV2</accession>
    <name>A0A6A8FJV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA topoisomerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000293">
        <property type="protein sequence ID" value="MRN69092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="2">
        <location>
            <begin position="11"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="325" mass="36793" checksum="1999B385980E7E1F" modified="2020-06-17" version="1" fragment="single">MSLTRIAHSPYTLVVCEKPNAARRIAQALGTLSFKEISALEIVGRRGLPPVFSVVDRNNQHFVVCSALGHLYGLVDVNRNRSTYPVFDVKWMPVLKKRNRKGPKTATRSVQIIKSIFLLSQKATSFIHACDYDQEGEVIGYNVLEYACKNKYESSLRAKFSTLTDEEIRNSFDNLLKPSKGLAEAGRSRHMIDFIYGVNLSRALTQSFKVSNDRKRYCNLSIGRVQGPTLAFVVDREMEITRHVPEPYWNISGEFEKNGHIIKVHYYQQKISTLSEATSIVNACTNEDGKITGIENQKVTFKAPTPFNLGDLQKEAYRVFKFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV5</accession>
    <name>A0A6A8FJV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_07365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000531">
        <property type="protein sequence ID" value="MRN69501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_S25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="118" mass="12507" checksum="396809FA099B1A3B" modified="2020-06-17" version="1">MRQICTGSMGGSKKKPLGAEKSSPASGHDGDKPAKKEETKKALGKVQQKQKLSVLVEDTQGRRAIQSMKAITIQGVARAAGVKISVANAYIKSLEAKGIVKSVGGYSGHRVYQLIEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJY1</accession>
    <name>A0A6A8FJY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosylhomocysteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000549">
        <property type="protein sequence ID" value="MRN69521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="158" mass="17313" checksum="E9D0538245EE02D4" modified="2020-06-17" version="1" fragment="single">MNYHVKDTSLADEGKKRIDWAEVHMPVLVALKHKYESEKPLKGTKIAGCLHVTKETGVLVRVLQSVGAELSWCGCNPLSTQDDVAASLAIHENISVFARRGISTKEYYDDINSVIGIRPNITIDDGADLTVEMHKNMNGSKSVIYGGTEETTTGVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJZ5</accession>
    <name>A0A6A8FJZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000049">
        <property type="protein sequence ID" value="MRN68360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="216" mass="25151" checksum="AFF1A1916EBF74BA" modified="2020-06-17" version="1">MERVAAIYLAHLNPFTNTHRHIISLLLQRDYNVYVYPVRFLKNHKEINTRSFPFPYHIRKAMIESVFGNNKSITVSPDYSLVSPFVRYLPPLISPFSWILRNQILRNVREEKFITYTGDVAERITLSVFKLNPIKARRFAGSASAVKDMLYDQITTKFSNGSRGEQRHEEQNWRDMVPSGVADLIEHNWQIVEKFARSSDSTLKVMGMKIPKEGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK19</accession>
    <name>A0A6A8FK19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000200">
        <property type="protein sequence ID" value="MRN68879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="202" mass="23293" checksum="B6C0C2B9B05B4462" modified="2020-06-17" version="1">MHKNDIPKIIALQRKSFSDMATYGMIWPSAFLENHIRVFPDGQLCAELNKEKKVVASASSLIISLKPVYREHTWHEVTGHGTFNNHDHLGDSLYGADISTHPKLQGQGIGTMLYGARKDLVIKLNLKRMILGGRLYNYYKYADTMTALQYVQNIINGKFSDPVLSFQLKNGFRFIKVLPDYLYDKRSLNYATFLEWINPKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK35</accession>
    <name>A0A6A8FK35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylglucosamine-1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_02645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000102">
        <property type="protein sequence ID" value="MRN68577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="330" mass="35718" checksum="C39B23F43095B74B" modified="2020-06-17" version="1" fragment="single">MLDLSFWNYILFYGTIVSAASFLSILLLTPKVIKLLIAKGSVVQDYHKPERPNIPRPAGPILIIGIAVAEIILYLLTRNIQVLAILLTTIIAFIVGLIDDKKVMPGWYKPVALIPAAIPLIVLGAHGTHLNLIFGDASIPLLYIPLILIIIPVAGNTINSIDVLNGVASEAVIVAMIPLLVSIAVFGNNVVFIAGLPLLFGMIAFYKYHRFPSKIFPGDSGTLLIGAMYGALAIAGRSEIIGVIALLPSVMNSFLFLDSVKKIVEHRQIKSRPTVLMEDFKLMASKEKNAPTTLLRLILADGPLSEKEIAKKILKLAIYSSVLALTTVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK39</accession>
    <name>A0A6A8FK39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_05615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000326">
        <property type="protein sequence ID" value="MRN69162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="213" mass="23684" checksum="1644A5D8BA32DA04" modified="2020-06-17" version="1">MNPLEFAGEVILVSASGVLSPGPLFFINIIYGSKQGITGGIKIAFGHTMVEFPLVITLALGLFTFSHIFINNENLKIISIIGGIAIIVFAFIQIISITKGKDDKQNAYAGINRKKGPILLGVIFSALNPFFLIWWLTVGLKLISDSIHFFGFVIGILFLFSFHIWMDYAWLVITSYLIYRGVSVLKTKFYSALLISISTILAFYGIYIILKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK80</accession>
    <name>A0A6A8FK80_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">FIO04_05870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000353">
        <property type="protein sequence ID" value="MRN69212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="74"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN69212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="319" mass="34098" checksum="9A6F40391AAEC2C1" modified="2020-06-17" version="1">MSSFFLQGKRRGDKIFYIVTIGAAAYTLLMLALIVYTVGDGSQKIFSFEGMKFFTGTNWNSVEGRESFGALPYIIGTLISSGIAVAIGVPISLGIAVFLSEMASSKISTPLSFVIELLAAVPSIIYGLWALFVFRFWILNLVEMPLYNAFGKSIPFFGVTPFGLDWFTAGIVLGIMIIPIVSSICREVMRAVPNTQREAAYSLGATRWETVRIAIFPYAKSGILGAAMLGLGRAIGETMLVTLIIGNAIGAAAIPTSLFSPSQTLSSLIANEFNEASSDLHLSALIGLGAVLLIITMVINIGARLLVSRMVKVSAGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK98</accession>
    <name>A0A6A8FK98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_04410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000218">
        <property type="protein sequence ID" value="MRN68923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="151" mass="16429" checksum="CBC736125DE5664B" modified="2020-06-17" version="1" fragment="single">MSNPNYGVWRPMAENVEFNALESNSNAVMAVADTVRTTLGPKGLDKLLIDQAMNRHISNDGVTILLSLRAIHPVARMIVEIAERQEQLVGDGTTTAVVMAAEMIKEGKRLVKELGVHPTKVVEGIEGGVKEACQLLEKEAKKISLNEIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKB5</accession>
    <name>A0A6A8FKB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000367">
        <property type="protein sequence ID" value="MRN69242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="88" mass="9618" checksum="DFA82768A42BC5B1" modified="2020-06-17" version="1">MNSSERVRARGHKASREITPEQAANKVKDVAKTIREVSSTARDTVKKFRESGAITELAEAVHEAAATRDTAKEISDTAKLPKRSEIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKE6</accession>
    <name>A0A6A8FKE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000389">
        <property type="protein sequence ID" value="MRN69282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="369" mass="40539" checksum="EAD88B49AD79A688" modified="2020-06-17" version="1">MIQVNGYAAQQAKAPLTSYSFERREPRDHDVAIDIQYCGICHTDIHQVRNEWGASTFPMVPGHEIAGVVTGIGAKSTRYKMGDRVAVGCFVDSCRKCGPCREGLEQYCAEGPTLTYNAVERDGKNRTQGGYSNKIVVDENYVLRIPENIPMNRAAPLLCAGITLYSPLMHWKAGPGKKVGIIGLGGLGHMGVKIAHALGAEVTVLSHSLRKQEDGKKMGADKFYATSDPETFEKLKGYFDLLINTLAVEIDWNKYLNLLALDGTMVVVGIPEKETPIGAYSLISARRSLAGSVIGGIRETQEMLDFCSKNNIACDFELIPIQKVRGRLQNTCTVRKKLNQLAITVISVVQPFYPSTNLKFLGQEDDSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKH1</accession>
    <name>A0A6A8FKH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000470">
        <property type="protein sequence ID" value="MRN69406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="58" mass="6369" checksum="79FADDB822A3CD7F" modified="2020-06-17" version="1">MEGLLISGNADGVDIALATDFYELTMAAAYYYRYFIRPADKATSDSKSEKGIIAKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKH6</accession>
    <name>A0A6A8FKH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000263">
        <property type="protein sequence ID" value="MRN69029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="163" mass="17466" checksum="60B8C9795BC3C430" modified="2020-06-17" version="1">MSNKPTQRDKQIITVAVALTFGLGAFIFPTMTNSFVPSAYALNWHPAHLNVNLQQLLAQINQCVDQGTQCFNSGNNQANIHLHQGWFSHVDLGQSLAQVNDCSGGSSCINSGSNNANIHVGNHHSSSNSNYAKIDQSVVQENHCSGGSTCINSESNTANININ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKL3</accession>
    <name>A0A6A8FKL3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000497">
        <property type="protein sequence ID" value="MRN69446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="99" mass="11377" checksum="AA1D367D4D894982" modified="2020-06-17" version="1">MKNRSEIEIMASILRSATKDWEYKTTIMNNAMVSHSQLIRYLAIAVERGLVNYSENSGLYRTTEAGQEYLGKYEQLILLLPTIPELPDLSDSEEIHQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKL8</accession>
    <name>A0A6A8FKL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000106">
        <property type="protein sequence ID" value="MRN68590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="223" mass="24119" checksum="697C748E285A2D2E" modified="2020-06-17" version="1">MLINWQMETGSRKSKFTVYQCCKRGHTLKCASIVKTGGVIVYPTDTVYGIGCNPYLEEAVERIFEIKGRNKVNPFPILASNLQDIEKIALLGKIGKRLAKIFWPGALTIISTLIDTRISTKVTAGKTTVGVRVPDNKCAVALLKHCKYLVGTSANKSGENPSNSISEVILSSLRGFDAILDGGNIRQGSASTILDLSGHVPKIIREGAISSEEIARVLSTNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKM9</accession>
    <name>A0A6A8FKM9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisG</name>
        <name evidence="8" type="ORF">FIO04_07130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000503">
        <property type="protein sequence ID" value="MRN69456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="7">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="112" mass="12615" checksum="7D425C4946559309" modified="2020-06-17" version="1" fragment="single">MPTVKFAIPKGSIEEATFKILEQAWQSISGRGRTYRVKLSDPEIEVKVLRPQEIPTYVQEGFYDVGITGKDWVREAKADITTLLDLEYGKVKQVIAVPESFAVEDLTGLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKN1</accession>
    <name>A0A6A8FKN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF488 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_06805</name>
        <name evidence="2" type="ORF">FIO04_03455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000262">
        <property type="protein sequence ID" value="MRN61739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000153">
        <property type="protein sequence ID" value="MRN68737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="116" mass="13844" checksum="1B8B6B6F4591013D" modified="2020-06-17" version="1">MTIKTKRVYDKPEEDDGYRVVVMRHRPRFLKKGSYNRWMQELSPSAPLLKSYLTRMIDWDTFTSGYHKEMKSNPVSQQAIHELREKSKVTDVTLLCHEKDGENCHRYLLKNLIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKP3</accession>
    <name>A0A6A8FKP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4242 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_05115</name>
        <name evidence="2" type="ORF">FIO03_06350</name>
        <name evidence="3" type="ORF">FIO04_05215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000074">
        <property type="protein sequence ID" value="MRN40406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000236">
        <property type="protein sequence ID" value="MRN61655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000288">
        <property type="protein sequence ID" value="MRN69083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="84" mass="9358" checksum="B03DB93E0991CF67" modified="2020-06-17" version="1">MPVFLDVHKVPFTEEHLKELCNAPVDEFGVSHVNLLYNKEANVCFCILDAPDVAAVENHHNKAGVKCEWITEVNLARAVPSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKU6</accession>
    <name>A0A6A8FKU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000504">
        <property type="protein sequence ID" value="MRN69458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15174" checksum="8635E2BBA8247039" modified="2020-06-17" version="1">MPTSMVIRHDNKQNSGKLKDAASLLLKGGTLIKDPCPSCSGIQVRFQNENICINGCNPQDIVGQPTLTESADNKGNLNRNTNRGLAKSIIQEKIMILVQQLRDENDISAQKLKADLIEIYLRILEKTAALEDPRYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKV4</accession>
    <name>A0A6A8FKV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000326">
        <property type="protein sequence ID" value="MRN69163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="105" mass="11811" checksum="1DD7B0C99BF034DE" modified="2020-06-17" version="1">MRTGGLNEILKTLLDNDNKGISNPELICLLQKIENDATEIYHAKYGTNEKIKFNIDCDNTSNANLIGRQSAKSLQCIRQSIKKNVDLMGEDIKTIFQSYLTECGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKW3</accession>
    <name>A0A6A8FKW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000331">
        <property type="protein sequence ID" value="MRN69173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="76" mass="8263" checksum="95E847674A7F6517" modified="2020-06-17" version="1" fragment="single">MQDLFKTYCIIGDPIDHSLSPAMHNAAFKSVGLNCAYIAFRVPKGELEVSLGSLRATNISGFNVTIPHKVGIIPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL49</accession>
    <name>A0A6A8FL49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03865</name>
        <name evidence="2" type="ORF">FIO04_07520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000109">
        <property type="protein sequence ID" value="MRN61177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000557">
        <property type="protein sequence ID" value="MRN69532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="112" mass="12631" checksum="9C39B348C097451D" modified="2020-06-17" version="1">MVSVDEGEDLEEKKLLGSGGYVFAKLTEQEELSASLGVPQIFLGNVGRLNESRFSKYYCNKCGKEYPGSAVINYENPNEELGEGVILVEKGEYKCRICNNVIAHYRKFNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL61</accession>
    <name>A0A6A8FL61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000566">
        <property type="protein sequence ID" value="MRN69542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="entry name" value="PTHR38811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="135" mass="14372" checksum="CE81785FB584D295" modified="2020-06-17" version="1" fragment="single">MSRNQYPDIRTINQGNSSITRFSTKSPLFVCVISYTDTSTIPGITAAGANRDLVKYTPAADAEFLYYGFCKCIDKVPITPDGNPTPAIITRGALGLADIPFLVVDAGSKIKPSIPYVSFGIDPGHNIESGVAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL71</accession>
    <name>A0A6A8FL71_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000170">
        <property type="protein sequence ID" value="MRN68790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="244" mass="29096" checksum="A86407B45B376DD6" modified="2020-06-17" version="1">MFGGHITLNGNLNQTINKSTFLLYKKIGEQYYDFQILEKIKSLIPEHIARLNEDDKIKSTMGWFKNDFMSWTPKDPRWNRCMDKGRGNLMHVRIVPGNSWKLRAMEIHRCDKCSYEYSFPRHGQILKIAEARTGRCSEWSMLFGAVMNVSKIETRIVHDFLDHCWNEALLKGKWVHMDSTLEYPISLDHPHYYEQNWGKNYKYVLAFSNDRVEDVTQTYTQNWDAVIKRREQKRPSFFRGLFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL73</accession>
    <name>A0A6A8FL73_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0147 protein FIO02_00115</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_00115</name>
        <name evidence="4" type="ORF">FIO03_03925</name>
        <name evidence="5" type="ORF">FIO04_03780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000001">
        <property type="protein sequence ID" value="MRN39437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000111">
        <property type="protein sequence ID" value="MRN61189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000173">
        <property type="protein sequence ID" value="MRN68800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00342">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN39437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN61189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="96" mass="11022" checksum="41D9883FCA8289B5" modified="2020-06-17" version="1">MTTTKKELKRKENEERLSNAIATLDTISKNINIQRNIRNMIKEVYFALKDEKSGTVSVRAANAISTLDTVTQNPQMQSHIRTMLWQVVSTLESIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL94</accession>
    <name>A0A6A8FL94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000394">
        <property type="protein sequence ID" value="MRN69289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="68" mass="7087" checksum="302E142BBA34DFFD" modified="2020-06-17" version="1" fragment="single">MERFDVAIVGGGTAGFSALQQLSNLGKQAILIEAGKTPGSKNVSGGILYSKTPKNGKVYNVEDVFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLB7</accession>
    <name>A0A6A8FLB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000406">
        <property type="protein sequence ID" value="MRN69309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="177" mass="20351" checksum="566AA11AEB45194B" modified="2020-06-17" version="1">MVLLCGKSIVDLHRNEIKEGEKKIEEARLLLNEFRPYAKTDLQRYMVDAEQEFVEASMLKSICEGSPLPLREDLNVSGPSYITGILDTIGEIKRLIYDRMRTSQTTDVIRLFGLMQELYNAVYVLGVYDNLIPGLRRKLDISKMITEDVRAVVTEDSRRQLMINALAILEKKLKDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLI1</accession>
    <name>A0A6A8FLI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_03345</name>
        <name evidence="3" type="ORF">FIO04_04295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000039">
        <property type="protein sequence ID" value="MRN40064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000208">
        <property type="protein sequence ID" value="MRN68900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="139" mass="16521" checksum="1D9F23451DDDEA91" modified="2020-06-17" version="1">MRAYLSEAEIYNDYSLPPLIQTLKEIKQEFSQQVFLKATEEDRNIIGSVRAYLEKETAYIGRLIVKPDSQNKGIGTRLMQAVEQHFKFADRYELFTGYKSARNLYLYQKLGYLEFKRIPVNDSLMMVFLEKYRNNNQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLN4</accession>
    <name>A0A6A8FLN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000300">
        <property type="protein sequence ID" value="MRN69107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="79" mass="9112" checksum="683A29284649CAA7" modified="2020-06-17" version="1" fragment="single">MGINKNKKKLKWKVDYENSLYKIYDWDKKLAGYFFPRYGSVESGETGELNDEHTDELNKSKAKVSGGNLLVPMLKLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLQ7</accession>
    <name>A0A6A8FLQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">M3 family oligoendopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_04695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000242">
        <property type="protein sequence ID" value="MRN68980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="9">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="205"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="599" mass="69314" checksum="A0CC47ACEC02FD6D" modified="2020-06-17" version="1">MFMPKLGTWKLDDLIKDPTGNEFQEYLESIATKVTQLESKRKDLQDNISTVEFENFLHSIEDISEKVNIASGYAHLIYAADTSSNERAALVTKMAMFGSNMANRLLFFDLWFKKEVGEETAQRLIESVSPVYREYLKHQRLLAKYTLTEPEEKIITTLEVTGTSALIKIYDRMTSGFEFVVTFKKGRKPIKRTFTNREKLLSLIRSTKSGEREAAYNSLLQVYKKNSGVLGEIYQNRVIEWRDEYLTMRGFRSPISVRNTYNDLDDTTVETLLAVCRRNSVVFQDYFKQKAKMLGVKKLQRYHLYAPLSLKASDQKRFTYGKAIDTVLRTFEDFHPKFREYAEKVFNEQHVDSEIRKSKLGGAFCSSISPKMTPYVLLNFDGKSRDVSTMAHEFGHAIHSMTASDKPITVWDAPLPLAETASVFAEMLLNDKLSERITRVERRILLAEQIDDMYATITRQAYFTLFEIDAHRAVAEQNATIDTVSELYLNNLKEQFGNSVNVSRDFQWEWLYIPHFYHTPFYCYAYSFGNLLVLSLYHQFNSEGKKSFIPKYLKILSAGGSQKPEHLLKESGIDISKDEFWQQGFDLVAAKIQELKEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLR9</accession>
    <name>A0A6A8FLR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000246">
        <property type="protein sequence ID" value="MRN68990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6488" checksum="12895C7598CCFA06" modified="2020-06-17" version="1">MNIIAHILSDKGIVISNELVFPSSNLPWLNRNKDNIRFVKATDDNKILKRILRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLT7</accession>
    <name>A0A6A8FLT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_07320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000525">
        <property type="protein sequence ID" value="MRN69493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="3">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="156" mass="17400" checksum="93C1B7987CE9273C" modified="2020-06-17" version="1">MSNSSNSAAADAEGASSSNKVEIIRGLNEDLAREYKAIIQYVVFSSTLKGAEYGDIAEQLKKHASQELAHALEVARQIDYLGGDPTVKGKEAEYSQESRKMLEIDLRAEQETIKSYRERIRQAERAGEFALSEALRDIIAEEQDHEIDLRDALGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLU1</accession>
    <name>A0A6A8FLU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000329">
        <property type="protein sequence ID" value="MRN69167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="166" mass="18761" checksum="A370D49D4239E292" modified="2020-06-17" version="1">MGATFPQIPRSLPNNMELHSSADIVSDAVDTSSTILDILSAISDDKSLAIFRVIAEDDNTGVESLIICRNLQLTHKKYYRRLAALIRYSLIIRKDGSKKYILTSLGKVVYTTLLSIQYALDNIWKFRAIDEVKICENGVYKDIDKIVSSLVDTLVHKEQIREILKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMN7</accession>
    <name>A0A6A8FMN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium-transporting ATPase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FIO04_06325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000401">
        <property type="protein sequence ID" value="MRN69300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN69300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="189" mass="20434" checksum="5A2853097CB8126A" modified="2020-06-17" version="1">MNMIGEKGLKILEQIKSQINKNILSPPIKVVILMLVVTGIVYPLVLVVIGQSTLPYQSNGSLITVNGKVIGSKLIAQDFKSPKFFHPRPSTESASNVDPDITPENALLQISNVSQATGINQNALTTLIELNVERNRVSNMVAFAPDYVNVLEINLELLNQYPDVYSTFLNNADPQKTTAGITGLGGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMT4</accession>
    <name>A0A6A8FMT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000553">
        <property type="protein sequence ID" value="MRN69527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="185" mass="21653" checksum="ED2B761870AC3295" modified="2020-06-17" version="1" fragment="single">MTSYSHPEVLCETDWVADNIHGKNANIRILEVDYDPENAYRQGHLANAYLVWWRKDINDADRRDIINKQQFEALMSKVGATPDTELILYGDFNNWFAAFAFWVFRYYGHKKIKIMNGGRKKWELEKREYTKQDPTPAEGRFSLKYIAQPPDEGVRAYLPDVKRAMEKAETVLVDVRSPKEFTGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFE9</accession>
    <name>A0A6A8FFE9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_01730</name>
        <name evidence="3" type="ORF">FIO03_02150</name>
        <name evidence="4" type="ORF">FIO04_00110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000015">
        <property type="protein sequence ID" value="MRN39753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000048">
        <property type="protein sequence ID" value="MRN60847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="88" mass="10028" checksum="7E1451E2F5A3F971" modified="2020-06-17" version="1">MKYRSRTDIAALILEAANGGAAKTKIMYRAFLSYAQLKEYLAVLLENGLIEYSKAEQTYRITQKGMRFVQLYNQVGELISTGERIIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFL4</accession>
    <name>A0A6A8FFL4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="4 13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpA</name>
        <name evidence="17" type="ORF">FIO04_00515</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4 13"/>
    <dbReference type="EMBL" id="WJXC01000013">
        <property type="protein sequence ID" value="MRN68165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="15">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_Xtn" evidence="16">
        <location>
            <begin position="84"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="14">
        <location>
            <begin position="211"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MRN68165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="588" mass="65424" checksum="DA41825B4136A80A" modified="2020-06-17" version="1">MAESLVSRISGPVVVATGLEGAQMYDVVRIGELGLVGEIIRLEGNKATVQVYEDTTGLRPGEKLVNTKRPLSIQLGPGLLTSIYDGIQRPLNILREQSGDFIGRGKTIPALDQEKKWEFIPLKKRGDEVCQGEIIGEVQETPLIKHKIMIPFATQGKLEEISEGRYNVNEIVATVKTPTTKVDVGLSSWWTVRTPRPVLRKLPPESPLLTGQRVLDTFFPVAKGGTAAIPGPFGSGKTVTQQQLAKWADSDVIVYVGCGERGNEMTEVLTTFPELEDPKSKRPLMERTILVANTSNMPVAAREASIYTGITMGEYYRDMGYGVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLGRRLAEFYERGGKAIVVSPEERIGSLTLVGAVSPPGGDFSEPVSQNTLRVTRVFWALDASLASRRHFPSINWLTSYSLYADDMSNWYSQNVSPEWVPLRKEALEILQRESELEEIVQLVGYDALPEPEKGILDTARSLREDYLQQSAYDEVDTYTSIRKQFLMLSVILEFGKMEADAIKKGVRSSRIGALDARKLISKIKWTPEDQVEQLLREIKTSMSQQFEGLLIQVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFR5</accession>
    <name>A0A6A8FFR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="7" type="ORF">FIO04_00155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000003">
        <property type="protein sequence ID" value="MRN68094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="320" mass="35442" checksum="3738323DAC50B6FC" modified="2020-06-17" version="1">MLAHYNDSNKSSSNHATTAISTSLAKCPSCSNEKIITDSESGEIICVKCGRVISDKLQEIGPEWRTFSTDETEAMTRTGIPQSLARHDMGLSTIIGRTDRDASGNKLDAAMRTRMNRLATWDMRSQLHTPKDRGLRQAFFQLDVLKDKLGLSDSIVEKTAYIYRKAQSRKLTRGRTVSGVLAAAVYIACREMGAHRTLDDIAIACNVKRKELTKDFRVLHTRLGLKIPQQDPMKCIAKVASKAKLSEKTKRHAAQIMNKVTREEISAGKDPMGLAASVLYLSSIENGETITQSNIAEAAGVTEVTVRNRAKELRNKLEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG17</accession>
    <name>A0A6A8FG17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1116 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000046">
        <property type="protein sequence ID" value="MRN68345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="415" mass="45332" checksum="0A135E2C874263FF" modified="2020-06-17" version="1">MSEQIKNRIEDANRQAVERVLRSRPILVDIKPAIEVLSGMKKNSIFHAGPPIEWKRMSGPLRGAIVATMIFEQLVESWDEAVKLIESGQIEFSPNHDHDAVGPMAGVISPSMPVLVVKNEKFGNTCFGRLVEQKVQFGVFDEDAVQILKFWAKTLGPALGKAIRVSKGIDLKSLMARALHMGDELHNRPVAGTALFASIITPYLIEVLDREELVKVTKFFSTNDIFFLCMSMAACKTIMNAARDIEYSTLVIAMARNGTDFGIKVSGLGNEWFIGPAQMIEGRYFPGYKHGDANPDIGDSAITETAGIGAFALANSPAILSLIGGSAEDAIKYTKQMREITMTLNDTFSIPILDFQGTATGIDIRKVVKTGILPVIDTAMAHKQAGIGMIGAGVVRPPLEAFKQALYAFGRKYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG40</accession>
    <name>A0A6A8FG40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000020">
        <property type="protein sequence ID" value="MRN68204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="97" mass="10963" checksum="2E8FF3302D054122" modified="2020-06-17" version="1">MEQAEKFELYDKPLITGTSVASFKNYSQSIVAEEKRLQKQQESPEKLSPTTTKVIDVFGEMAEPICDYLRCHHKLSVHGLGTRVCQCRHPRNIAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG50</accession>
    <name>A0A6A8FG50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000022">
        <property type="protein sequence ID" value="MRN68214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="323" mass="34617" checksum="1DF0914B98A0A769" modified="2020-06-17" version="1">MLLSNEQKNADMRGAYGDTLVELGASNQNIVCVGADTTDSLKIKKFGDYYPDRFFNVGIAEANLVSVAAGLAIAGKIAFASTYAAFLPGRCLDQIRNSICYPDLNVKLVVSHAGLTVGPDGASHQQLEDFSTMRAIPNMRVIVPADAVAAKYLIRSIAMIPGPFYVRLARPSSEILYEDNAIFTIGKGNILRDGSDATIMACGLMVTRALDAAKVLKSNNGIACRVVDMFSIKPIDTQLVAKCARDTGAIVTAEEHNMIGGLGSAVAESSSETYPVPIRRLGVRDTFGESARDEEIDALLEKYGLGTNEIARGVIECRGKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGB2</accession>
    <name>A0A6A8FGB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_11155</name>
        <name evidence="2" type="ORF">FIO03_04115</name>
        <name evidence="3" type="ORF">FIO04_01220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000327">
        <property type="protein sequence ID" value="MRN41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000119">
        <property type="protein sequence ID" value="MRN61226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="120" mass="14303" checksum="3AE86FA9834657AB" modified="2020-06-17" version="1">MSYDRFVDERLLSSRDALNKFQIKMKILDFDENARDFSQRFGRRLLVKKTLLTIKHILTEEIEERELDVEELEKRMRKERLFSSSNRWISPSEIKNGYILASRHLDLLADAIALDVVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGD8</accession>
    <name>A0A6A8FGD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000043">
        <property type="protein sequence ID" value="MRN68331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="302" mass="33681" checksum="A3A8828FD2F0DB26" modified="2020-06-17" version="1">MRDSNHKLANEVDLVLAAGGDRGILDYFHKVVTDSAPVLGVYESDSTGFLAQLDVRDLESAALRLKKGDYEIDEVLRIAVKVDGREVEPVLNDVAVFSSKSAILMEHVLRIDNKDVWHDNSDGVIIATPTGSTAYSMSAGGPMVLQKSRVFIVVSVNSVDNTRRPLVVPNETVLKISNIMSRYHCEVVLDGGSRFAIRRELECQKHQFPARFVRLRADSAAISLITKKVKLAEDLLSMPPSAKLILKTLEYEGALSQRDLTTRTLLPERTVRLSLSHLLGRGYVKRKTSLRDARQKIYELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGQ1</accession>
    <name>A0A6A8FGQ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpB</name>
        <name evidence="9" type="ORF">FIO04_00520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000013">
        <property type="protein sequence ID" value="MRN68166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="7">
        <location>
            <begin position="132"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="465" mass="51209" checksum="9154CD7D8DF60AE3" modified="2020-06-17" version="1">MSTISFKTLSKIAGPLIFVEGVDNAAYGEMVEIKLVDGQRRQGQVLDTRKGLAVVQVFGPTLGLGTSGTSTRFLGHTATLSVSDEMLGRVFDGLGNPRDNGPKIVSKQKFDLVGSGINPYSREQPSEFIQTGMSNIDGMNTLVRGQKLPIFSGAGLPHNMLASQIARQAKVLGTTESFSVVFAAIGITSEEANFFVKQFEESGALGRTVLFLNLSSDPSMERILTPRLALTTAEFLAYEREMHVLVILTDMTNYCEALREIAAAREEVPGRRGYPGYMYTDLASIYERAGRIKGRKGSVTQIPILTMPADDITHPIPDLTGYITEGQIVMSRDLQRADIHPPADVLTSLSRLMNQGIGKGRTREDHRSLADQLYATYAQGKDARALAAIVGEEALSEIDRKFLKIANSFERKFVNQGFDENRSIEETLNIGWELLSDLSESEMKRIKPEFIEKYGRKKAVTPEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGQ3</accession>
    <name>A0A6A8FGQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_01605</name>
        <name evidence="4" type="ORF">FIO03_00530</name>
        <name evidence="5" type="ORF">FIO04_01810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000014">
        <property type="protein sequence ID" value="MRN39731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000008">
        <property type="protein sequence ID" value="MRN60528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000059">
        <property type="protein sequence ID" value="MRN68414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN39731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN60528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="85" mass="9669" checksum="96B50EDC8465BF07" modified="2020-06-17" version="1">MVSRRKQGQTVLKGLGVKFGATVRKRYSKAYRTLKQKRRCPSCGSNKFCRIALGVWYCRKCSYKVAAGAYDVATDKLQSPNRNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGX4</accession>
    <name>A0A6A8FGX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_02170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000077">
        <property type="protein sequence ID" value="MRN68484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="625" mass="66500" checksum="17BD67F385BA9E97" modified="2020-06-17" version="1" fragment="single">ASNMDTLIAIGTSAAYLYSTVVTIVPGYFPFKSVYFESAAIIITLILIGRLLETRTKEKASDAVRKLLDLQPRMTKVMREGGEEVEIPVEQVQEGEVMIIRPGERIPTDGIVIEGSSSIDESAITGESIPVDKEKGDEVIGATINKSGLLKVKATKVGQDTVLSQIITLVEEARTGKAQMQRLVDQVAKYFVPAVLAIATGVGLGWYFVGDIGLTFSLLAFVSIVIIACPCALGIATPAALMMGAGRGAENGILFKGGEYLEIAKKVKTIVFDKTGTLTKGKPSVTDILDLSGIGENELLRLAAIAESGSEHPLGQAVVNNAKEKGIPVISNPTSFEAVSGHGLRATYADHTILIGNRKLMDDNNIPVTETVDTTLTQLEIQGKTGTLVAIDNKLAGIIALADTIKKNAKDAIDILTNSMGIEVAMLTGDNERTAKAVASKLGISRVIAQVLPQQKQQVISKLRDEEKKVVAMVGDGINDAPALAEADLGIAIGSGTDVAKETGGIILIKDDLMDVPIALDLGKKTVSKIKQNLFWAFVYNAGLIPVAAGALVPLFGLNMFGWLPMLAGLAMAMSSVTVVGNSILLGRYKPKFKVSKGRRMELEKQKIFSNYDLKQTAITSHSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGZ5</accession>
    <name>A0A6A8FGZ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="14">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FIO04_00035</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="14"/>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="12 14" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="15">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MRN68072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="918" mass="104226" checksum="AFF5E393D27E78F9" modified="2020-06-17" version="1">MAGVTEFNDQEKNLIIRIRKRDGREVNFEPLKISDAIYKALVATGKPDFSLSEKLANKVVQKMIHHGYGSTEIPSVEDVQDVVESILIEEGLSDTAKAYILYRHERRKLRDEKMKILNKKVLDEVDKAFDINSLRVLAARYLLRDGNNEIVEGPKQMFERVAILVAIPDIMHDSHLFALSRDKNYNRSIEEAEKYYSKLNDFDLKLKIGKYYLNKYHFEAIIRHYIDLAKQEHMKITFKELLRLIAEGKFAAYGERIKEYYNLMVSRDFLPNTPTLMNAGGRLGQLSACFVLDMPDDMQGIMKSSTDAAMIFKSGGGVGINYSDLRPEGDIVASTSGVASGPTSFMRIIDTITDVVKQGGKRRGANMGILEVWHPDVEKFVTAKTKPGIFENFNVSVGVWDDFWRSLVTQDKNLKYTLRNPRTREPIKQIDSHALMDLISFSAWKSAEPGVIFFDNINKYNPCINAKGGPLRATNPCGEQSLYPNESCNLGSINLANFVKRKADGRYEFDWQRYEQAIRLASRFLDNIIDINKYPVDEIDANTKLTRRIGLGIMGLADLLFLLRIPYNSEDGYEFMYKLAETMSYYSMEESVAIAKARGAFPLLEETDYVKGKIPVAGYYELPKEMHTYDWNSLIEKIKKHGIRNSWTSTIAPTGTLSMIADTSNGVEPIFAVAFEKRVTVGRFFYTNRVFEAVLRENSLYDDEILSKIANNYGSGRGLPEIPGWIQKIFVTAIDIHWTDHLMAQAIWQKWIANAIAKTINMPGDVTAEDVKCAYLLSHDLGLKGVTVYRDGSRHEQVLHITGENTKERRFSVVPSRYAIDYIRENISEPYVLEALEKIFKDIQRPDSDEPLEKGVLSVERQQHSKIEPASASLQTHPLSSQYGLTENEFCPSCRAKLIMTEGCDMCIECGFSSCVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH15</accession>
    <name>A0A6A8FH15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_08735</name>
        <name evidence="2" type="ORF">FIO04_03445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000195">
        <property type="protein sequence ID" value="MRN41112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000153">
        <property type="protein sequence ID" value="MRN68735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="96" mass="10949" checksum="6F9990FF5E706AC5" modified="2020-06-17" version="1">MTLNSCQKEEEYAMNVIGKVVYDNLIDLEHLHYEHIVFALEAHSELIKQRMMAAHAVDGGSKKRKQVEQILGRISQAAIETVKQELKANPIEFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH29</accession>
    <name>A0A6A8FH29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000090">
        <property type="protein sequence ID" value="MRN68534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="119" mass="13256" checksum="F5D14988C85E65DA" modified="2020-06-17" version="1">MSSTAIDESMLRINQLIDKMSAMEQEIANETEILKEQYINASSAMGDAHNYFLSGVESAPSQKSYLLTSRGIEVLGEEVIPISAFIDNVVRYAVSPKNKIEVLYNLVTHLKKLDQMLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH37</accession>
    <name>A0A6A8FH37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000031">
        <property type="protein sequence ID" value="MRN68266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="211"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="347" mass="40058" checksum="080A70A84D35FC6B" modified="2020-06-17" version="1">MSDVPNPSSRGQHVMLLYDINSNRDLAAINYINQGLAEKQLCIYASVSAYDTSHLSKISCRIKNYEENIDKRNLFIVNLKPFYDSVLAGDLTPFEEFKVQLQQELKDRDVLIVADCADNLFRNKHFDQCELVEKWWQENYIEWRRLRQNHITIICPHSGSLLSKHPFDHHKHQISHNHTVTIDTTSRRVTGYITAKEVAESAIPPLEIPIQILVAEPERDLQQIYSIWLRSMGFKNMAITDSGKKCIDELLNITDTSKNKTHGFDMIIILDTHLKDIPCIQVAREIVNKRPDQRIIFTTTLPPDSVRQDLYSIGIKNNNEILLKPFRFSKLLSLIGMSISNQQDRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH41</accession>
    <name>A0A6A8FH41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000099">
        <property type="protein sequence ID" value="MRN68571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="120" mass="14009" checksum="4D5B6BF004D75864" modified="2020-06-17" version="1">MKPNRPVGRHDNSRGLMATNRYASSKILAVHKRFVRLVTPKRFVAFVTILRTKILSQLIRNVKPKKFVGLHDNYRRLMGTNRYPSLEIFAHNLRHVRLVMLKRLPTIIMVVTLRRLGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH62</accession>
    <name>A0A6A8FH62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000098">
        <property type="protein sequence ID" value="MRN68564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="284" mass="31848" checksum="4DD87633C702EE24" modified="2020-06-17" version="1">MVGQRKILVIGATGQQGGAVARLLLQKRHEVYALTRNTESETPKEQYLRNLGAKLIKGDLENPDSLEQATNGVDSVFLMGTPAGDGPEGETRRGKMMTDIAKEKKVAHLVYSSIVNADKNTGIPHFESKYKVEQHIKNCGIPYTIIGPTSFMENLLSYSRAGLQQGQLALPLSPSTILQQIALENIAEFSTLVLERRNSFLGKRIDIASDELTGEQAAKILSDELGRKIKYVQVPLEQIRQASEDIALMYEWYERVGTGIDITNLHQQYPEVNWRRFKDWVKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHB7</accession>
    <name>A0A6A8FHB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000187">
        <property type="protein sequence ID" value="MRN68845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="209" mass="23539" checksum="01F23CDF94D1176B" modified="2020-06-17" version="1">MSTKKEEQKQDSRSSGATNPQEAKSRRDATTIAKKLETLVDEKEGKKYSVDQQSHGMIKALDESKENIRQGINEAKAEIPRFTQIVKDFQETAIESTKEISDAFIESQRQVISSLQSVWIPSLANLYGSIWNYWTLQPIVSDIYVSMVRITADNVIATTRLANNIIFTSIEAAKALMPQLKDNAKELLRLSENAAKSFEQTSRRALNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHH4</accession>
    <name>A0A6A8FHH4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="4">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="4">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">folD</name>
        <name evidence="7" type="ORF">FIO04_01015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="4"/>
    <dbReference type="EC" id="3.5.4.9" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000030">
        <property type="protein sequence ID" value="MRN68262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="6">
        <location>
            <begin position="123"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="289" mass="31106" checksum="EEFC667AC9A7844E" modified="2020-06-17" version="1">MTARILDGLVAAACLRSNVKRAASQLRSEGINPCLATVLVGDDPSSALYVRNKHKAAAAAGILTRDHKLPSSCTQRELLELIGTLNRDTEVHGILIQLPLPTQINEFLVLSILNPVKDVDGLTPYNAGMLVCGKAILKPCTPAGIVELLDFNKVDISGMDSVIVNRSTLVGKPLAFLLLERDATVTLCHSKTKMLVDKLKTADVLITAVGNREHFVLTADMIKPHAVVIDVGISRYDGKLAGDVDFENVKEKASWITPVPGGVGPMTISMLLKNTITAASLKKEMNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHJ0</accession>
    <name>A0A6A8FHJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_03130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000131">
        <property type="protein sequence ID" value="MRN68674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="oligo_HPY" evidence="4">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="152" mass="16920" checksum="08321D2CFA9C74FF" modified="2020-06-17" version="1" fragment="single">LLLKPDIVIADEPTTALDVLVQAQIVNVLKRLKKENGMTIILITHDLGIISEIADKIAVMYAGQIVEIGKASEIYENPKHPYTQALISAIPKLHDSNKQIEFIKGNPPDLTRPPPGCRFYERCPHAMGICKEDPPEIATETGFTRCWLYAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHL2</accession>
    <name>A0A6A8FHL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000152">
        <property type="protein sequence ID" value="MRN68731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="166" mass="18292" checksum="FFEB1AC24D8E8D8E" modified="2020-06-17" version="1">MVSANYSQKGKRPNESKSETTIIMLPSDANPKGNVFGGVILKHLDLIAGLVAKRHAGHANIVTASIDRMTFLKPVYIGNALILSARLNYVKRSSMEVEVRIEAEDLDIGERVLTGTAFVTVVALDEHRKPIEVIPLILNTDEDKKRFHEGESRMMTRLKGAGRTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHM1</accession>
    <name>A0A6A8FHM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000069">
        <property type="protein sequence ID" value="MRN68456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="77" mass="8720" checksum="5CC3B212B3DC6C22" modified="2020-06-17" version="1">MAVRSGRSAKVTATARVLMNIIAITLLLDYSLSHKLRQAIRASRLTNGKEIKKQLNLLKENVRGLQQIRYILVPHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHM3</accession>
    <name>A0A6A8FHM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaK</name>
        <name evidence="4" type="ORF">FIO04_03475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000154">
        <property type="protein sequence ID" value="MRN68741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="592" mass="63626" checksum="63BB11B9F912658A" modified="2020-06-17" version="1" fragment="single">MGKIIGIDLGTSNSAAAAMIGGKPTIIQAAEGTSIGGKAFPSVVAFTHDGQLIVGEPARRQMISNPEGTVIAAKRKMGTDFKFNVFGKDYTPQQISSFILQKIKRDAEAFLGDTVDKAVITAPAYFNDNQRQATKDAGEIAGLQVVRIINEPTAASLAYGLDKVQKDLKILVFDFGGGTLDVTLMEMGGGVFQVKSTSGDTQLGGTDMDNTLVDYVLQEFKKQSGLDIRNDKAAMMRIREAAEKAKIELSNVVTTEINLPFLAYDSATGPKNLVLNLSRSKLEELLRPIVERCKSPMLQALQDAKLAPTDIDKIILIGGPTRMPMVRQFVATVMGKEAERGVDPMEAVALGAAIQGAIIAGDVATDILLVDVTPLTLGVEVLGGLKEPLIERNTTIPTKKSKIFTTAADYQTAVTIHVVQGERSMAADCVSLGMFNLSGIPPAPRGVPQIEVTFDIDANGILNVSAKDMATAKEAKITITANTKLSKEEIEKLKKESEQFAEADKNKRVEAEVKNEADNLVYAAEKLVKQDLKDKIKPEQADKINKAAQELKESISSNNIDNIKTKTQELKNIIGEVSTEVYRTVGATPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHN0</accession>
    <name>A0A6A8FHN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000071">
        <property type="protein sequence ID" value="MRN68466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="63" mass="6857" checksum="E2CC8948F8CF9FDC" modified="2020-06-17" version="1">MSDSPVVDWEAIVHKNVRSKDRADVGNVDAIETDAIVLITEGAHGEYRIPKSEVEGFDGARCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHQ8</accession>
    <name>A0A6A8FHQ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FIO04_01360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000042">
        <property type="protein sequence ID" value="MRN68328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="13">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MRN68328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="199" mass="21633" checksum="CC01CA44E358AEDE" modified="2020-06-17" version="1" fragment="single">MSTIQNDDEGIFRRIIKKISAYIPQVEKPKKKISLTEKFVWSGIALFAYLIMGQIPLYGVTSDPKFDFLAFARVIFAAQQGTLLELGIGPIVTAGLLMQLLKGSELVKLNFKNPDDRSLFTSATKIVTIIVIIAEGTLYGTSVYGHLVASPLFVPILVGQLIGASLIVMLLDEMVQKGWGLGSGISLFIMAGVAQGILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHS3</accession>
    <name>A0A6A8FHS3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_01410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000044">
        <property type="protein sequence ID" value="MRN68338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="242" mass="26484" checksum="46A95978FC08C4AF" modified="2020-06-17" version="1" fragment="single">MPDVSVVPLEETTTQILELINLGISSIIVFGVPTERDAVGSNASDQNGIVQKTVRKLKMEFGNALNIITDVCLCHYNLSGHCGLLASQNDLIDNDSTVRALCEVALTHAQAGADVVSPSSMMDGQVSSIRTSLDDHGYDKIKILSVSAKHFSSLYSPFRSLAFSEQIRDYKSLDKSSYQVPYTNRGESVREIENDIREGADMVIVKPAMMYLDVISMIKEKLRFPIAAQNVSGEYAMIKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHW4</accession>
    <name>A0A6A8FHW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_06380</name>
        <name evidence="2" type="ORF">FIO04_03950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000238">
        <property type="protein sequence ID" value="MRN61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000183">
        <property type="protein sequence ID" value="MRN68834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="59" mass="6626" checksum="7D40AA6FEED84411" modified="2020-06-17" version="1">MSRLILRCSSFFAAGRGAVHDRATNDRVFIKFLPITKTQSVDEGIYAKKAVNWALRQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHW9</accession>
    <name>A0A6A8FHW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000096">
        <property type="protein sequence ID" value="MRN68556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="78" mass="8168" checksum="016107098F645519" modified="2020-06-17" version="1">MGVITWIVIAVVILAIMGLGWQTFFAGVKKGADKVGLTSIVKNITDQAKQSFGGVVKNLSSQNTTKPATGSFSNKTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHX0</accession>
    <name>A0A6A8FHX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK family alpha-L-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000054">
        <property type="protein sequence ID" value="MRN68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="228" mass="25775" checksum="EF332CA9C573B416" modified="2020-06-17" version="1" fragment="single">MVELCVVYDKVRFEEKSIYDKALKKGIKTRMTDAKSITISTDSKRKELALGDVILQRSISHFRGLYLTACMEFLGFSVINKFKVGETCGNKLLTSLTLAKHKVPTPKTYFAYSAGAAMEVINKTGFPVVLKPIVGSWGRGVYPLRDEEVANMIIEMREENDNPLGRIYYIQEMVERPPRDLRCIVVGDEIIAAVYRYSAENEWRTNVARGGKAENAPITNELKEIALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI00</accession>
    <name>A0A6A8FI00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000105">
        <property type="protein sequence ID" value="MRN68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="110" mass="12985" checksum="950D9D4C4B95D7A7" modified="2020-06-17" version="1">MDSKPFTFRLQLTKTQQKEVQTYLESLSIGMILFGLRFAYKRERAISGGYLMPGRKSIVKKETVMLNHTQAGWRLNNWKAMIRSYRDKGYSYPTISRIKKEIRVIAYNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI27</accession>
    <name>A0A6A8FI27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gatC</name>
        <name evidence="1" type="ORF">FIO02_03410</name>
        <name evidence="2" type="ORF">FIO03_00320</name>
        <name evidence="3" type="ORF">FIO04_00745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000040">
        <property type="protein sequence ID" value="MRN40077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000005">
        <property type="protein sequence ID" value="MRN60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000021">
        <property type="protein sequence ID" value="MRN68209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="90" mass="10398" checksum="1A9D93226D20DD9F" modified="2020-06-17" version="1">MISKDEIRHLGWLSRLELTDSELDRYATQIDEIISYFDKLDNVSLTGSDPARSIKKVSELRNDNIHVFEGDPLEFSKNRKDGFVKGPRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI53</accession>
    <name>A0A6A8FI53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000310">
        <property type="protein sequence ID" value="MRN69125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="50"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="240" mass="27104" checksum="2525884B98A2E8B4" modified="2020-06-17" version="1" fragment="single">MESSEWRFQSLLVFIVALVTLILTGSFLPAIGYSIQLSPTPSGNSSASSKVVMLTFGDTLKSQFTNAKPILDKYGFKGSFFITCLWVGSDKARMTWQDILALQMDGQNIESKTMTHRRMTNLSPNDLNYEVAGSKKCLADHGINATIFATTHGNEWNNATVINAIAKYYNFAVNGFAPLMFLHCDGYKQSSQHDCRTYFDNGTLTFANRYSIREWSHNNIDKAYSYNDTKIFQRFVQEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI87</accession>
    <name>A0A6A8FI87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000015">
        <property type="protein sequence ID" value="MRN68173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="131" mass="14600" checksum="8DA6FD487532EEE5" modified="2020-06-17" version="1">MSVKGMVMEETLLAHGHTMPSSARASIKRIVMGHIHPVFSRCNSVINGRRIWLYLKVKREMIFPGTVGTLDIIIVPSFNKDVPMIHKRYAKSISPIINRALQHNAIEQAMAVTLDGSIVADDRNVVARLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI95</accession>
    <name>A0A6A8FI95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-3B C(17)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000234">
        <property type="protein sequence ID" value="MRN68961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021745">
        <property type="entry name" value="CbiG_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11761">
        <property type="entry name" value="CbiG_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CbiG_N" evidence="2">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_mid" evidence="3">
        <location>
            <begin position="140"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="282" mass="31122" checksum="9AF8CF1C0A4297FB" modified="2020-06-17" version="1" fragment="single">MTGNTAVIAITRHGIDIANRIMEKMPEIQVYAPIKYADQSMPNMNWFKEQTSQLVANLFKKNDALICIFSLGAVVRLIAPFLVDKKTDPAVIVIDDKAHFVISALSGHLGGANSLARLVSSFFDNCQPVITTAADVNETIAVDLLGREFSWTIDNFENVTKVSAFMVNEEKIGVLQETGEKEWWQNKSLPSNVTVVRKLDDLKSSHFKGALVISDRIIDDPLILEKSVLYRPKSLVVGIGIHRDTNSGVIEHGVKNTMKNEGLSFNSIRNIASINREAGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIA9</accession>
    <name>A0A6A8FIA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CofH family radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_00660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000019">
        <property type="protein sequence ID" value="MRN68193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="72"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="385" mass="42723" checksum="C7142A2258644180" modified="2020-06-17" version="1">MQHILYLDFIDSASLLKGVGGSGGVGTPALEKAMAGQELSYKDGLQLMNEENLFLLGAAADNIRKYLKGNSVTFVASYYLNYTNVCAASCPLCAFYRKGNDADAFTLSTEQILTRARIAIKEMGSTELHIVGGFHPKLGLDYYENMMRVIKAEFPSVVIKALTPAEIFFISRLTRNSVKEVLLRLKAAGLDALPGGGAEIFDPEVREIIVRGKCSSEEWLDTARQAHELGLKSNCTMLFGHVEKPEHIVEHILQIRELHKKTRGFTTFIPLKFSLENTEIEKNNIIKTESPSTYDLRVIAVSRLLLANVLNNVSVYWVALGKKLAQVALSYGGNDMVGTAFSEEIFRAAGKDTGTSIQELASLIKEIKREAVQRDTFFNIIRRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FID9</accession>
    <name>A0A6A8FID9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000252">
        <property type="protein sequence ID" value="MRN69001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="2">
        <location>
            <begin position="8"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="323" mass="36572" checksum="48ED698AE29B7D25" modified="2020-06-17" version="1" fragment="single">MNLTSVIKTDSGIPVRKVYKKNSLRKKTQDQEPGRFPYLRGIYPDMYRERLWTMRQYSGFGSAEETNNRFKFLLSHGQTGLSLAFDLPTQTGRDSDDSQSEGEVGRTGVAISSLKDMVTCFEGIPMDKVSTSMTINSTASTLLSLYISVAELQGYSPGKLRGTTQNDILKEYIARNTYIYPPKPSIRLIGDTIEHCYKHVPQWYPISISGYHMREAGCTAVQELAFTFANAIEYISTCVDRGIKIDDFAQRLSFFFCCTMEFFEEVAKFRAAREIYAKIMKDIFHAKNAKSLHLRFHVQTSGESLTAQQVDNNIVRVTTQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIF7</accession>
    <name>A0A6A8FIF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ORF">FIO04_05935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000359">
        <property type="protein sequence ID" value="MRN69225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="242" mass="26170" checksum="2EC00BFE84A59EC6" modified="2020-06-17" version="1">MRGLLITGTDTGVGKTVIAAALVRVLRARGINVGIMKPFAAAKGIFSRKYRSKDTAILARAAHATDTDREMNPFFYSVPAAPYVASAVTKQTKVSMSTVLDAFHNLAIKHDIVIVEGIGGLMVPLTQTETFADFVKILNVPTIVVARCSLGTLNHILLTVNASKAYGLDVMGLVMNGFPQRETAVDKQLLTAVKKLAGVEVLCVIPKVAEVTNMHFKIEEIVVDKILPRLHIGTFVSEMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIH4</accession>
    <name>A0A6A8FIH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000281">
        <property type="protein sequence ID" value="MRN69064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="351" mass="39357" checksum="77B9CAD0FE8D3CBB" modified="2020-06-17" version="1">MRYKLLGKSGLRVSELCLGAMTFGEDWGSMLPGASKEEARKIFDLFVSKGGNFIDTANVYQNGTSENYVGEFVSAEREKFVLATKYTLTTNPDDPNASGNHRKNLVQSVEASLKRLNTRYIDLLWVHIWDPLTPIEELVRSLDDLIRSGKVLYIGISDVPAWVVSHANAIADLRGWSSFIGIQIMYSLIERSAERELLPMARALDIGVTAWSPLGGGVLSGKYIKQDSKEQKRFNVNNPMSASFVNERTISIATEVQTIANEMNKTPSQIALNWIRQQHDRGIIIPIIGARTEAQIKDNSACLDFELTADQLRRLDEKSKIQLGFPHDFISEAARIFTYGNTFSLIDNHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FII9</accession>
    <name>A0A6A8FII9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sixA</name>
        <name evidence="1" type="ORF">FIO04_05105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000280">
        <property type="protein sequence ID" value="MRN69061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004449">
        <property type="entry name" value="SixA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00249">
        <property type="entry name" value="sixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="140" mass="15482" checksum="CA8A54FDC4F43000" modified="2020-06-17" version="1" fragment="single">MDLFVLRHGEAGKRLSSDSSDFGRPLTVTGKREVTDIAKSLKELGVQFNFIITSPLKRSHQTASLVAMTFNSENNMENWDELNPEGNGKEIYRKLSQKFKKDSSILIVGHEPYLSTLISEVISEGNRVGTAGGQVVLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIJ4</accession>
    <name>A0A6A8FIJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ORF">FIO03_06575</name>
        <name evidence="10" type="ORF">FIO04_01525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="9">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000246">
        <property type="protein sequence ID" value="MRN61694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000049">
        <property type="protein sequence ID" value="MRN68359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN61694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="106" mass="11674" checksum="CEAD1AC507578526" modified="2020-06-17" version="1">MAEAQPQQNPQVHRDGPRDAVYIGKKPLMAYVTSTLIQLANQPSVTIKARGLSIGRAVDVSQIILKRMENAGYRVGEVRIGSETVQSEDGRTRNVSTIEIEVKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIL4</accession>
    <name>A0A6A8FIL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000052">
        <property type="protein sequence ID" value="MRN68379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="153" mass="17394" checksum="823E564AA6F75D73" modified="2020-06-17" version="1">MGDSKKIDFEVREISDTDLQRGFFDTLSNLTEVGKISEDHENAKKVLHEIRSYPFYKVFVAVKKDGEIIGSNTLLIEQKFIHNGGRVGHIEDVATKKGYEGLGIGRALVGRSLRFAAQMKCYKVILDCSEKNVPFYKKIGFKKRGLSMRYDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM0</accession>
    <name>A0A6A8FIM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1802 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000175">
        <property type="protein sequence ID" value="MRN68806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014923">
        <property type="entry name" value="DUF1802"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008307">
        <property type="entry name" value="UCP018957"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08819">
        <property type="entry name" value="DUF1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018957">
        <property type="entry name" value="UCP018957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="245" mass="28096" checksum="C2398C5BFC951696" modified="2020-06-17" version="1">MSAFIRAWKISSGVLDSEVMPPSDQSATEVSIERIKAIDTTTAALKEWAVVCKALEEGRQVILLRKGGIMEYRQGFEVKHTDFFLYPTFEHQSKEFLQPNYVNKLDIVLQNAPVNNRNRITSCATVVLVKEITNKSVLGRLEKYHIWNDQYINVRFSYNPKRPLNVVVLRVYKMNTPLEVDVKPELTGCKSWIPVQLLLSDTKLQQDYDNQSGSAIDIIKPDCKPVFNDSEFTEIVTELQEVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM2</accession>
    <name>A0A6A8FIM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_10580</name>
        <name evidence="3" type="ORF">FIO03_09680</name>
        <name evidence="4" type="ORF">FIO04_05370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000289">
        <property type="protein sequence ID" value="MRN41472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000519">
        <property type="protein sequence ID" value="MRN62291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000303">
        <property type="protein sequence ID" value="MRN69114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN62291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="140" mass="16201" checksum="6E371826A3CA443B" modified="2020-06-17" version="1">MATIGRKKRILIVDDEPDITLAFKKILEENGFKEQVDTYNEPLLALQDYKAGIYGLLIIDVGMPGIDGFRLYQQMKQIDNKPKVLFATAFYVHYDVVRGYFPIEDENNEIEEILGDTGGRFIRKPIDMETLIRRVRSELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM9</accession>
    <name>A0A6A8FIM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000392">
        <property type="protein sequence ID" value="MRN69285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="293" mass="33548" checksum="FB6685F437228A37" modified="2020-06-17" version="1" fragment="single">MQDVMTSSVSSSIDYPPGPHSILPNKLLRRFLHDPIKTLMEITRTYGDISHFKFGRQQHIYLLNNPRYIEDVLVKNHKNFTKNKTRQTTKRLLGEGLVTSEGEFHDRQRRIIQPTFHPNRIKTYGEIMITSAARMCQQWEDGITLDIHKEMMHVTLAIISKSVLGSDIKSQDEVGNALLTCMEYSNRVLMPFGQLISKIPILPVNKGYQRAKKKLDLIVYSMIKEHRDNESKGTSNADLLYTLLQAQDAEAGIGRMNDSELKDEVMTIFVAGHETTANALTWTFYLLSQHPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN4</accession>
    <name>A0A6A8FIN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_01730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000056">
        <property type="protein sequence ID" value="MRN68399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="9"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="114"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="332" mass="37096" checksum="826B42E34AEC9E48" modified="2020-06-17" version="1">MKPKKWSVYITRRILDPAIPMISKECSVIVANHRGRPPTRNELLKAVRDKDAILCTLSDIIDAKVMDAAGSNLKVISSYSTGTDHIDIKEATKRGIYVTFTGDILTEATADLAFALILATSRQITQGHELVTSKRWKYGWDPHLLLGSDVHGMTIGIVGLGRIGSAVARRAKGFDMDIIYHNRHSRNIQMEEQFGAKHVDMNQLVEESDFLSLHCSLNSESYHLINESNLRRMKNDSYIINTARGQLINEAHLIKALKQRWIAGAGLDVFEKEPPSPNNPLLKMKNVVLLPHIGSATFLTRTKMAEVAAKNLLNVLNRKTAIYLANPEVNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIP1</accession>
    <name>A0A6A8FIP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000181">
        <property type="protein sequence ID" value="MRN68826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="56"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="475" mass="52777" checksum="2930969E839A0D14" modified="2020-06-17" version="1">MQNTCDVLITNAAGVVIPKVGIVQTNIMIENGKIKALTKSTQSVQASRKINAEGKYVLPGIIDPHVHYGVYTPIEEAAKTESKSAAIGGVTTMMRMLRLYDRYENIEKHLRASEFTHHVDYSIHASILRPEQIKDIQYLKKKFGINSFKIYANLGHDVNHILMDIEPGTHQTVEREVNISDQIISDIVQEASLRQSPVLVHAEDQVMCSRLQKQNQIRSELTGTKITSLRVWSECRPPSSEANAIAKVGAYAREFGSTIYFVHIGSGTALDSILTEKEKGNSNLYTETCPHYLTHTSDFFDVTGKVVPPLRTKIDVQSMWYGLMNGIIDTVGSDHVANTLLIKRGQGDIWSARAGFPGIATLLPVLLCKGVNEGRISLERVAEVTSYNAARIFGLYPKKGTIEKGSDADVTIIDLDLLQKVTPEILQSYSDYSIYNGWELRGWPVFTIVRGRVIMENGQVDKNTCGYGEFVRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIP7</accession>
    <name>A0A6A8FIP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000317">
        <property type="protein sequence ID" value="MRN69144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="67" mass="7628" checksum="14FDBC2E64FD8555" modified="2020-06-17" version="1">MKCSGYEEWIYGALKKLNNNNKNQTCVKWGKGVEGHDYFASLYFCGNSKFEITRGLNKENTIGGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS0</accession>
    <name>A0A6A8FIS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000136">
        <property type="protein sequence ID" value="MRN68688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="362" mass="41909" checksum="F5763885B3FB5414" modified="2020-06-17" version="1">MLKNLKGDKKSNNIKFGCYIYQDSLGYKDIKHIALECEKLGYESVWLKDNFIPWIQDYASFNSNRNNNSSEHRRQEKDQQQNHQQQDPSERMMLECWTTLSSLASVTTKIRLGAILVNLYRNPAIVAKMASTLDFISNGRLEIGLSAGWYQKETQAYGIVFPIDSIRVEMLEESVIILRKLLTTEDNNNNHGKISFRGKYYNLSDAECNPKPIQKPHIPIWVGGSGKKTLKVVAGYADGWNYGLCSYDQYVEKLSFLKNYSYNNKVRAKRNYDDIIKAWHGILFLGADEEELESRKTNILCKKRIWKDSNLVTAGTPDTIIREINRYLNIGVTYFTVWFPDLPDTRSLQLFAEHVIPCFRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS4</accession>
    <name>A0A6A8FIS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_03170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000134">
        <property type="protein sequence ID" value="MRN68682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="369" mass="42364" checksum="641E1485946B08DC" modified="2020-06-17" version="1">MISYQVLKGDCYEVLKRLSADPEERGKYRLVVTSPPYYGHRHYGKDPHEIGQEQTAEIFIKKLADIFTICKDLLTEDGSLWIVIGDTRRRFGKLLIPHRLALKLVDRGYTIREDIIWFKKNNVSSSSKDNFSQAYELILFLSKSEKSLANMSSMRVRGNEAREGRNKTPPRHMVQYESINRDKNRIEEIKEIIRNAKPDTNFNELPTTGEISRAYGYDPEKYCPTCYRKFKRHATRKRIGDHKHYPIFAVCNPAGKNPGNVWDISTKAHYGNEHFAIFPEDLITKIVNFATRKGDWVLDPFAGRGTTGIVSGLLGRNFTGIDLYQENVTRAEKNILNTIKGKISIKLQDQIQSTSIQNVPSLEAYLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIU4</accession>
    <name>A0A6A8FIU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_05660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000330">
        <property type="protein sequence ID" value="MRN69171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF-2" evidence="3">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GTP_EFTU_D4" evidence="4">
        <location>
            <begin position="101"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="227" mass="26214" checksum="E32214A361A9647A" modified="2020-06-17" version="1">MRYDWFYRSGYGPPQKGEHSNIRRDVIAASAVREKDRYVGVVLGFNTKILEEAQKESQERNVKIINDRIIYNLVRSYTDWIKFQKEHEDSILFNELAPVCKFQFLKGFIFRRNDPAVFGAEVLVGKLRQKVRVINDGGKKIGVIHQVQENGKSIEEATKGMQIAVSIRGPVIGRQINEGDVFYTDLNSKEAKMLLERFKVRLNPEEEDVFGKILLLKRNEDAAFGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV0</accession>
    <name>A0A6A8FIV0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-aspartate dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadX</name>
        <name evidence="9" type="ORF">FIO04_01700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11788"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11784"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the L-aspartate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.21" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000055">
        <property type="protein sequence ID" value="MRN68393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01265">
        <property type="entry name" value="NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022487">
        <property type="entry name" value="Asp_DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020626">
        <property type="entry name" value="Asp_DH_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011182">
        <property type="entry name" value="L-Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="DUF108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005227">
        <property type="entry name" value="Asp_dh_NAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03855">
        <property type="entry name" value="NAD_NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="8">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF108" evidence="7">
        <location>
            <begin position="176"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="278" mass="29332" checksum="0E8E5365D4DDD78C" modified="2020-06-17" version="1">MMKVCLIGCGTIGSELAVAIDSGKVGSATLVALFDTVEDAAQKLKLRLRKDNVALFSNFSELASSSEFKDADIVIEAASQAAAKTFSKHVVENKKDLLIMSVGALADEFFLSQLLSEVHTNGNHIYVPSGAIAGIDAIRSVKGMLDSVTLTTTKNPRALAGAPFFNSEPTRLNSIKKKTLVYEGTAADAVNKFPANINVAAVLSLAGIGIQQTKVKIIADPNITVNQHQIEATGAFGEMSITVRNVPSPNNPKTSFLAILSAIECLRSICEPGIKVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ4</accession>
    <name>A0A6A8FIZ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpD</name>
        <name evidence="8" type="ORF">FIO02_04140</name>
        <name evidence="9" type="ORF">FIO03_00915</name>
        <name evidence="10" type="ORF">FIO04_00525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum02</strain>
            <strain evidence="9">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000054">
        <property type="protein sequence ID" value="MRN40216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000015">
        <property type="protein sequence ID" value="MRN60603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000013">
        <property type="protein sequence ID" value="MRN68167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN40216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN60603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="223" mass="25637" checksum="7020CC3ECACBC970" modified="2020-06-17" version="1">MPSAINIRPTRLEYIRTKRRIVIAKKGLKLLKLKRQALILEFFSTSKTAATLRSGLQSELMKGYESIRMAEMMAGAIRLENEAMKIPSMTNLQIKSKNVMGVRIPKLVGGQRQEALTEYLLELPTSINEAIKSFQQVHKMVLDVAEKETALRKLLLEIEKTKRKSNAIENVFVPRLEAAVKFITFRLDEMERDTFIMLKTVKRKMGEREEESIKKEEQKILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ7</accession>
    <name>A0A6A8FIZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000085">
        <property type="protein sequence ID" value="MRN68519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="176" mass="19080" checksum="0099A5F0CA779BD9" modified="2020-06-17" version="1">MKENNNHNDVNRPANKNTKTIAVIVVVAITITLVISLSMRSTTMIGAQMGGGNKPIIMHFHPILTITVDGKPMTVPGQIGIDPALWKDHSLDQYGMQAMSDGMSSMAPLHTHDDSGTIHVESNTIRNYTLGQFLDNWGGLNVTGKTVKATMDGAPVSDYKNIILRDGEQINLDVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ01</accession>
    <name>A0A6A8FJ01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000165">
        <property type="protein sequence ID" value="MRN68772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="161" mass="16958" checksum="C63CC6EDA1D2A8E5" modified="2020-06-17" version="1">MQKQSRPRGVSIIAILIIIAGVLSLLLGIGLVVIGPFLMNGLQTTSSNLGSQIGPQILGLVFLVFGGILLGLGVANLVMAYGLWKGKGWAWTISIIVLFIGIAINILSVSITGVFSNTGQNLLGDIVSGIVSIGISAFIVYYLYRPHVKAYFGKTIPMPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ14</accession>
    <name>A0A6A8FJ14_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative snRNP Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO02_00460</name>
        <name evidence="5" type="ORF">FIO03_06655</name>
        <name evidence="6" type="ORF">FIO04_07020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000003">
        <property type="protein sequence ID" value="MRN39506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000251">
        <property type="protein sequence ID" value="MRN61709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000489">
        <property type="protein sequence ID" value="MRN69435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01731">
        <property type="entry name" value="archaeal_Sm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022901">
        <property type="entry name" value="snRNP_Sm-like_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="PTHR10553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN61709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="76" mass="8190" checksum="4B61B468691359E3" modified="2020-06-17" version="1">MSVDMAVKVLDESLGKVVLIKLKGGKVIRGNLHGFDQHMNLLLEESVEILDQGKSNDLGTIVVRGDNVVIISPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ16</accession>
    <name>A0A6A8FJ16_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000071">
        <property type="protein sequence ID" value="MRN68463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="199" mass="22674" checksum="AAF1C4AC8BFD0099" modified="2020-06-17" version="1">MDILRTKIKDVEQQQLIESTIRNAKRLKNLSDDIIEVTQIEGQTLRLHKERFNIIYVITETLEDLNNQIENKKVRLVHDAKDDIIFIEADKPRITQVLYNLLRNAVKFTEEGTILVNVQKPLQEDLIVSVKDAGTGIDLGIFPRLFEKFASKSFQGLGLGLFISKSIVEAHGGRIWAENNPNAKGATFYFTLPIANLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ17</accession>
    <name>A0A6A8FJ17_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_04375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000215">
        <property type="protein sequence ID" value="MRN68916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="281" mass="29961" checksum="5123FFA5BC288FAD" modified="2020-06-17" version="1">MVTDLKAFVVVSIPSMFLFGMRHALDVDHITAIDNLVRMHNARKSARWVGTGFSAGHMISILSEMLLIIYIVGSTTSGKLDQLSFSGGVTGAIALATIGAINIYSMKRWGKTGSAILASKIVTRTHILRPFGSAVVTGLVFGIGFDTATQISALTLSVVASATLGVQVALMLAGFFALGLIPVDTLDSVVLRSAFSRMFNTKGFTYLSYALSGVALTIAAFESYAVITNVKIVPPLTGPVLAIIIIAGAFGYGFATRKRRVVDQSISPRQHDHDEDFNSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ21</accession>
    <name>A0A6A8FJ21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000019">
        <property type="protein sequence ID" value="MRN68197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="74" mass="7808" checksum="85D71575938EACA5" modified="2020-06-17" version="1">MKGGTDTLSSSSKRKIQMPAAARSGLALLIVGAIFVGVGSYTHRGGFSLYGLPMVMVGFSLYLVSSIITARKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ34</accession>
    <name>A0A6A8FJ34_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_02165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000076">
        <property type="protein sequence ID" value="MRN68483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="309" mass="34910" checksum="39724D9B7754E52E" modified="2020-06-17" version="1" fragment="single">MWVERYRPLTLNEVIDQKEIVNALRQLTNIPNELPHLLFAGPPGVGKTTTALCIARQLLGEEWRRDTLELNASDERGIKMVRERVKEFAAVMKLITGNRDEKPFRIIILDEADEMTSEAQTALRRIIEDSSRTTRFIIICNYLSQIIEPLQSRCVVFRFTRLAKEDLVRHLKTICEKEGTKFEEKALSQIYDATSGDLRHSINILQASAGMGSVTHANVIASRGLSGKSKVGEVIRLALAGRFTDARVKLFELTNVYGLSENDFLKYANQEAYDMKLDHPDEFAALMAEYDYRLAAGAHPEIQLAALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ44</accession>
    <name>A0A6A8FJ44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_06955</name>
        <name evidence="3" type="ORF">FIO04_06115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000123">
        <property type="protein sequence ID" value="MRN40763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000378">
        <property type="protein sequence ID" value="MRN69261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="75" mass="8295" checksum="82AEE3289ABFDAC5" modified="2020-06-17" version="1">MQSDITNMTLLLLSIMSSNVGIESVSVSSIMTKDVKTAKENQTLHSVCRVMHDNNVGSVVIVKDEELHSMNNYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ70</accession>
    <name>A0A6A8FJ70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance/dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_01700</name>
        <name evidence="3" type="ORF">FIO04_00080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000015">
        <property type="protein sequence ID" value="MRN39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="132" mass="14913" checksum="4CBB7EC3DD3211E1" modified="2020-06-17" version="1">MLTKLGAIILLVADMKKSIEFYKGILELPLKHQSEDWTEFFSNGTILALHPAKKKEKTKAALTILVGFMVNDLDATVKRLKEKKVRFFKEPREEPFGKHAIFVDPDEHLISIVQFEAKSAEGFDLLGLIGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ77</accession>
    <name>A0A6A8FJ77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_01755</name>
        <name evidence="3" type="ORF">FIO04_00135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000015">
        <property type="protein sequence ID" value="MRN39758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="188" mass="20745" checksum="8C3BFBB2B6305C9C" modified="2020-06-17" version="1">MSFEQIIKIPQDRIGVIIGKGGKVKEEIEQKCNVTIEIDGENGDALVSSGPSPLTKAEPFKAIEIILAISKGFSPERAYRLLAEDLLQLIDIRDYAGKSANSMQRIKGRIIGKAGKSRKTIEELTGAYVSVYGHTVGLIGSFQEIRMGIEAISMLSKGSSHKSVYNMLQAARRKAKFDKMKLWEENSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB8</accession>
    <name>A0A6A8FJB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000204">
        <property type="protein sequence ID" value="MRN68892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="92" mass="10616" checksum="6CDC472E5F3AD631" modified="2020-06-17" version="1">MPSDSHAETLKAISDDKSLLVFKTIALTSPDSSSLQHKTKLTRKQYYTRTYRLIRAGLIKRRNGKYFLTAYGKIIYDAQKIIENAHTNLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD8</accession>
    <name>A0A6A8FJD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000125">
        <property type="protein sequence ID" value="MRN68649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="515" mass="55820" checksum="926ACB49501F2EE4" modified="2020-06-17" version="1">MRLNQLKKKLTNVLLVIASLVLLITPIVSVAAAATTTSTTISTATPIKHLVVIFQENVAFDHYFATYPNAANPSSEPAFSHSPYTPSINGLAAGLLTNNTNLVNPIRLDRSQSVIVTSCNPAHKYTLLQKSFDGGLMDKFVQNSGLSSQKNCDPKLVMGYFDGNTVKALWNYAQHFAMSDNFYSSNIDPSLPGHLNIISGQTHGAMPTNMSGNVANGTVIGDIPSVYDDCSVGTKISMTGKNIGDLMNEKGIGWGWFQGGFKPSGTTSNNKAICGTAHVNIAGKNITDYVVHHEPFQYYRSTANPHHLAPTSAAMVGKTDDANHQYDLSDFWNAADAGNLPAVSFLKASQYQTGHPGYSDPIDEQTFLVDTINSLQKLPQWNSTAIIIAYDDSGGWYDHVMSPIISQSNDPMNDGLLGPNLLCGHAPPSAYQDRCGYGARLPMLAISPYAKVNFVDHSVTDQSSILRFIEDNWNLGRIGDQSFDAKAGSLLNMFNFTTSHYAKNLFLDPYTGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ9</accession>
    <name>A0A6A8FJJ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000126">
        <property type="protein sequence ID" value="MRN68653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="395" mass="44296" checksum="D41BD201A05534FD" modified="2020-06-17" version="1">MMASPTRILMVSTEYPPMQGGVGRYTFNLTKELRKIGLQVYVACNEKGGGQFFGLSPNNIHNSEVLLRIVNEIQPDIVHVQYEPGLYGLVLDPFNPKKTNTNIESFYDKCKIPIVTTFHSAYTVKQWFSLGPTKTNRRNGNAAKLLLCRVGDYWKRLLNYRSFHNLNKNKLKNGQSGVVFSYYMSKMIVGGMDKGDIKIIYHGAEPAARMTKKEARARFSLPQEGQIALAVGFRTATKGWDILEKMKVPKGWTIVVSSSENHYIKYDLQLRIGNNSNIIILQNDFLSEFDLSSLFYASDAIILPYKVSSASGVMFDGLAHGLPFVATDLEFFREFSAQGLGITVRRNPSAFASGLVSLSSNYAGYRESVDIFKKKLSWNAVAIQHANLYKEKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJK4</accession>
    <name>A0A6A8FJK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_04055</name>
        <name evidence="3" type="ORF">FIO04_04785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000052">
        <property type="protein sequence ID" value="MRN40199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000250">
        <property type="protein sequence ID" value="MRN68998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="219" mass="24382" checksum="20D68811E59DEDB9" modified="2020-06-17" version="1">MGTTTLVTIYMVQIFTNMELKYFLSLEFTSAFVVVNVLLIAMANSFSLNTVYSQPYSSNTTTQSWIDNLNNIKVQFTYIPDKPTIDTPTELKFSVQNLHTDDPVKNLLARVVITSSSSGQQRIFKFANITVPDGKFSVKYLFPDSGIYQVIYNTGSKNNFSSLGSFKVLVPLQAASSISNPFGLSPSIIIAITIIIIAAVAAEAYFIIIKRREKIKYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJK9</accession>
    <name>A0A6A8FJK9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FIO04_06950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000482">
        <property type="protein sequence ID" value="MRN69421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN69421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="157" mass="17639" checksum="518638A4F53F0736" modified="2020-06-17" version="1">MSAAKKEVEMLQRLKNTGISIPLPLYRAMHCIAMNRINGARLVSVKDLEQPSIVLQNILLSVGIAYKNRIIHSDLSEYNVLVGETSCDTWIIDWPQAVTTDHPNAQQLLKRDVFNIVRFFNRRFAVGKNLDDALRDVLNSSSRTITTKNSAATNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL6</accession>
    <name>A0A6A8FJL6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO03_05565</name>
        <name evidence="6" type="ORF">FIO04_04885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="WJXD01000186">
        <property type="protein sequence ID" value="MRN61504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000259">
        <property type="protein sequence ID" value="MRN69018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN61504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="178" mass="20720" checksum="0DEAA13801619ABD" modified="2020-06-17" version="1">MMSRGIFVGRFQPFHLGHIATIKFALEKVEELVIVIGSAQKSHEMRNPFTAGERIQMIKDSLDAELGIDIKRILMIPVPDVRFHPLWTYQLDIMVPKYQSVFSNDFFTRLLYKERGIEVIQPGLHRRNELSGTEIRSRMVRGRDWKDLVTTQTAKFVDDIHGIERIKAIFMKHSESSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM6</accession>
    <name>A0A6A8FJM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000154">
        <property type="protein sequence ID" value="MRN68739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="75" mass="8247" checksum="0C46162C6BFD51C4" modified="2020-06-17" version="1">MTAIMSLNPEATTQQIENNFSTGQSWGALRKAWKGYRIAKVQGDNVKMTEYATKIRKIQGELGISVASFPNLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM9</accession>
    <name>A0A6A8FJM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl14p</name>
        <name evidence="1" type="ORF">FIO04_04935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000262">
        <property type="protein sequence ID" value="MRN69028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="68" mass="7278" checksum="A75C74602FE0125D" modified="2020-06-17" version="1" fragment="single">MAPKTRAVSAKGVEEFRPYITRVLPITAELVCADNTGAKVLRIAQVGRYKGRHSRLPAGAVGDLVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ6</accession>
    <name>A0A6A8FJQ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_03625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000164">
        <property type="protein sequence ID" value="MRN68769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="11"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="402" mass="43857" checksum="4933E3285D5826B8" modified="2020-06-17" version="1">MSTSSGTSWPIYLDNAASTPILDEVIREMLPYFKEYYGNPSSLHSFGRVTMRAIESARARVSSLIGCKQHEIIFTSGGTEANNLAIKGIAELVRKLNPKKNCIITSAIDHESVLEAFRDLEKKGFDVSYLPVTREAQIETAALKRAIIDDRTALVSIMFSNNEVGTIQPIRELATITHQKGGLFHTDAVQAVGKMPIDVKHLGVDLLSASSHKINGPKGVGALYKREGLKLAAIIHGGGQESTLRSGTENVHGIVGFGKACEIAAQRLVTSETEIRALRDYLIDRVLSEIANSRLNCFTQKRIANIAHFTFFGVNGEDLIIKLDELGIAASTGSACSLRHRRPSHVLKAMGFSYAELTGSLRLSIGILNTKQEIDQAVSILSQAVEELRKLSPFELGTDEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR9</accession>
    <name>A0A6A8FJR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000166">
        <property type="protein sequence ID" value="MRN68779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="65" mass="6888" checksum="AEB194EAF7379593" modified="2020-06-17" version="1" fragment="single">MGKRSYKNKITIMALIAGMIAAVAVTSSVSFFSYIEEAIATTTTTTNANTQVQVGGGNATWFFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU1</accession>
    <name>A0A6A8FJU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobO</name>
        <name evidence="1" type="ORF">FIO04_07310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000524">
        <property type="protein sequence ID" value="MRN69491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="178" mass="19403" checksum="465FD535879DC08B" modified="2020-06-17" version="1">MSASEGLVIVYTGKGKGKTTAALGIVLRSVGHGHRVIMIQFIKGEWYYGELTSSKRLEPEFEMIAAGKGFVGILDDDHTLEQHQDAALKATALAIEKLSTGLYDVMILDEINYAVKLNLISVQNVLEIVRIKPSKTTLVLTGNYAPVEVIALADLVTEMKEVKHPYGLGTKAIKGIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJY9</accession>
    <name>A0A6A8FJY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000047">
        <property type="protein sequence ID" value="MRN68350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="159" mass="18056" checksum="A88D54609665F823" modified="2020-06-17" version="1">MATGSRSFRSLEDFISNLHKCGAALTDFKGAKIPTIYIDASRYDEIMKRIYSQKVAVDTLLNIFHDGRHVFVDVQMKFLNTDLQENYLLYANNMIEFFESLSETGLISLAPDPSSISNSSNVFIIQLPKKELAEKALQIIRKNASNKVGLHDDCYDKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK25</accession>
    <name>A0A6A8FK25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_01575</name>
        <name evidence="6" type="ORF">FIO04_04235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000014">
        <property type="protein sequence ID" value="MRN39725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000204">
        <property type="protein sequence ID" value="MRN68889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_L18e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="PTHR10934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="4">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN39725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="117" mass="12994" checksum="50B2B5598A35C113" modified="2020-06-17" version="1">MMLANSLVGNIVWTLRKAFKKNKTSIWRSLEHEISKARSIRREVNISRLSSVTKNDEVIVVPGKVLGSGEMDHKLTVCAFSISEMAAKKITDVGGKVITLNELIDRYPDGRGVRIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKE3</accession>
    <name>A0A6A8FKE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000450">
        <property type="protein sequence ID" value="MRN69376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="258" mass="29498" checksum="8D0B1D6638B68467" modified="2020-06-17" version="1">MPEVSRTYFSPKDISVEISEIKDGIYRIAGFVKDYGITFNQFLINDEQPTLIHTGPIGMYDKIEEKLREVIPLEKLGYVAFLHFESDEWGGMEFLKCSKAKLLCSDLSSKLNLMGWYNVPTDHISFWDNELLKTGKRILRFIMTPHVHHWDSMMIFEDTTKSLFPSDLFLQPGANKPVLSEDLSEAMIAAYKEVGIFGSEEPVRQTTKRLMKLSPNMVFPQHGSCIDKSMFSKYTDAIMNNNFAYSGMLLGQELGTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKI1</accession>
    <name>A0A6A8FKI1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000478">
        <property type="protein sequence ID" value="MRN69416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="223" mass="25402" checksum="6636F287A1925FB2" modified="2020-06-17" version="1">MMKINHCIFPGDILYDTENFVWADIRHDKRKANIGITSILGYISGKLSVIKLRQVGSYIERGKSFGTLESPRYFGVVRAPISGRIIEVNHAIIDQPELANDSPYAEGWFAKMEISNIEEEIKNLQTIESCYEKMATLIQKHHIICFGAFPDYEMFQIGVECAATLTKLDELLEKITIGNVVHLVSDDTTADLEMVRWSEQTGQSLLETRKEGNLFHFIVKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKL9</accession>
    <name>A0A6A8FKL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_05470</name>
        <name evidence="2" type="ORF">FIO03_07270</name>
        <name evidence="3" type="ORF">FIO04_05145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000083">
        <property type="protein sequence ID" value="MRN40475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000290">
        <property type="protein sequence ID" value="MRN61828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000283">
        <property type="protein sequence ID" value="MRN69069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="95" mass="10600" checksum="644FC8926F511181" modified="2020-06-17" version="1">MRNKQKLKSISVLIPLQEVSASISQLDFSLDGITTIVAEGKFWKRMLYVNGEETISVSEEIGDAYPKDPIITICGSTHTVSKITEELQHYAGLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKN9</accession>
    <name>A0A6A8FKN9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_03505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000156">
        <property type="protein sequence ID" value="MRN68747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="107"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="529" mass="60935" checksum="DB3B48726C2C6C67" modified="2020-06-17" version="1" fragment="single">APFGWTKAFEIKVKGHPLAENYKIVTKQTSNIAPVVASSSDRINNSWETKVSSALREEEKLASIWYILEPDGKLSPIKEYKFNAGNQNLHALANYEMAKKRSTVEQPAHVRLMKRMGIADYEPASDVGNLRYYPKGKLMKSLIEQYVTQQVMEYGGIEVETPIMYDSKHPSMESYFNRFPARQYTITSDNNKQLFLRFAACFGQFLMAKDFQLSYKHLPLKLYELTRYSFRREKSGELSGLRRLRAFSMPDCHALCSNMEQAKEELLRRFELSTTVINALGLSTTNDLEMAIRFTEDFYNGNQTFINKIVSRFGRPVLVEIWKDRSFYFILKWEFNYIDSTGKASALSTDQIDVENGSRYGIEFVDENGEKKNPIILHNSPSGAVERVMFALLENCAKVARDGGKPSLPLWLAHTQVRIIPVSTQHLDLCREIYTELSRRKVRTDIDDRNESVANKIRQSETEWINYTIVIGDKELQTGWFVVRDRNQGEQRKIMLAQLGDEINSLTNGKPYIPLNLPPYLSNRPQIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKR3</accession>
    <name>A0A6A8FKR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000467">
        <property type="protein sequence ID" value="MRN69402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="274" mass="31089" checksum="7DCF85934E5412C1" modified="2020-06-17" version="1">MSYSVTHGIVKLKNEFIKNHATRSIVREVIPLSYSTLVPIAEQTLSRINDFVNCNPIYVESEDIHLFDIPCRAYLGDINDYWLDSKKHDANYQPFYPTWMLSAYALALGAKLLGFKDIVDIGSGDGRIAYCGKLLGLRSVGIEIDSKLTILQQAISALADVEYEIHQADATKFAYDSLHLSRPMFFISGLPEWGDMLASSAIPRIMEISELRECSGFNFMGSHIMKEYSRDKTGWGWGKIIEMYHLKIKKCITLPTCWTNDQKIDTAYVFTTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKW8</accession>
    <name>A0A6A8FKW8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease P protein component 4</fullName>
            <shortName evidence="2">RNase P component 4</shortName>
            <ecNumber evidence="2">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Rpp21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rnp4</name>
        <name evidence="3" type="ORF">FIO04_07590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000570">
        <property type="protein sequence ID" value="MRN69546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00757">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016432">
        <property type="entry name" value="RNP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004878">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="106" mass="12485" checksum="19E6E9187FB09E95" modified="2020-06-17" version="1">MRRQISKDIAKERVGILIANALKEAHTNEKIANEQAYLARKIAMRLRVRLDYEIRQLFCRKCKKFIIPGRNSRIRVGRTNTKSIRITCVKCGHTYHKILSGRTWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKX6</accession>
    <name>A0A6A8FKX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000181">
        <property type="protein sequence ID" value="MRN68827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="183" mass="20821" checksum="B5216DEAFCD4E5B7" modified="2020-06-17" version="1">MARTVSSQLLKVGEKAPDFRLKGVDNKLYSMKDFKSELVLVVFICNHCPYVKARIKDIVSLQEIFRLEELQVVGINSNDPNYEGEGFDKMVTFSKENTLNFPYLIDDTQNIAKAYGAVCTPDPFLFDSELKLVFHGRINDALEPDMHPKVQVMENNVKKILNGEKIEKPFDPSVGCSIKWKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKX8</accession>
    <name>A0A6A8FKX8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_09310</name>
        <name evidence="2" type="ORF">FIO03_03045</name>
        <name evidence="3" type="ORF">FIO04_07295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000221">
        <property type="protein sequence ID" value="MRN41226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000077">
        <property type="protein sequence ID" value="MRN61022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000523">
        <property type="protein sequence ID" value="MRN69488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="132" mass="15331" checksum="C147E8368FC10B19" modified="2020-06-17" version="1">MTTDSNKAGPTTLWRTLKGKNVRTNDGKDLGEIKEVSENYLHVEKGTVRKEKFWIPKYVADAFDGKTLWLLIGEEELRGRYQYGTQPPPGEQYSKEFESFKGTPYGQKANYESDFNENIRVVENYKNIRDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKZ7</accession>
    <name>A0A6A8FKZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Branched chain amino acid aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000187">
        <property type="protein sequence ID" value="MRN68847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="69" mass="8028" checksum="A6CBED2F81DC434D" modified="2020-06-17" version="1" fragment="single">MTEGKIWMDGSLVPWDDAKIHVLTHGLHYGTAVFEGIRCYKTDYGLAAFRLPDHIRRLMHSAKMYFMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL21</accession>
    <name>A0A6A8FL21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000563">
        <property type="protein sequence ID" value="MRN69538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="67" mass="7231" checksum="11642403D7E4AC2F" modified="2020-06-17" version="1">MYGASLPGAAKLHKVGARACTVVNVPTSWAQKLSNLSKKGGKIALSVVPNNEMRSLNIYYKYADVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL30</accession>
    <name>A0A6A8FL30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000362">
        <property type="protein sequence ID" value="MRN69233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="192" mass="21516" checksum="F4C0E821329D420F" modified="2020-06-17" version="1" fragment="single">MKGVIFDLDGVLVDSMPMHYEAWKIAFSEVANIKVDERTIYLLEGMRGIELVRNIFELKRIGPFDESILTQITKRKDEYFRKIFSFKPFEGVKELVTNLRCRKAVVSGSAKKDVERILGQALGFGKEQFDVIITADEVKKGKPDPSSLFSAVEKLMLNTTEAIIVENAPLGVEAANRAGISCIVVLNNTPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL34</accession>
    <name>A0A6A8FL34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000577">
        <property type="protein sequence ID" value="MRN69558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_2" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="102" mass="11210" checksum="D4624835914EC436" modified="2020-06-17" version="1">MTAYDSEAMLVGRVLEIGLRKSPRGNMDISIKISKQENSYNNSETVVTEEVLWKNISKIGDIVLLGERMRTSATNSPSQCASCGYQNEEGAVFCEECGKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLB2</accession>
    <name>A0A6A8FLB2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_06140</name>
        <name evidence="3" type="ORF">FIO04_06395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000100">
        <property type="protein sequence ID" value="MRN40607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000408">
        <property type="protein sequence ID" value="MRN69313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="110" mass="12656" checksum="142D4D0F4DA24F05" modified="2020-06-17" version="1">MTTQRSYRERIYIVKDIILKLVEYGELNQTALISCCGLNFKKHSPILGRLETKGLISKDQIEVGKRTVTAYKPTQKGIEFSRHILEPYEIMFPRSDTIPADNLAFLLILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLE7</accession>
    <name>A0A6A8FLE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_01945</name>
        <name evidence="3" type="ORF">FIO04_04130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000042">
        <property type="protein sequence ID" value="MRN60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000197">
        <property type="protein sequence ID" value="MRN68870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="90" mass="10409" checksum="5FF5CEC6AD17594C" modified="2020-06-17" version="1">MASTIFRVQSHKFSQDNIQTTLVCSKCDEIFSKEFPLDLEGQTIEFKCPVCGAPGEADLPYKSAEEREELEEDFEEVEEEEGEEEFEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLH2</accession>
    <name>A0A6A8FLH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000444">
        <property type="protein sequence ID" value="MRN69369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="157" mass="18099" checksum="97F63DF71A762F79" modified="2020-06-17" version="1">MLERVKVCLDTLRIITRSKPDKHKTTVAVVANLESVGVVKEALLKEGVDEKIIVIDSSPKNIAQTFDRVLDMIKSRINPPHIYFVGSVWQRDIYDSIVVSKLKGYRVQFEGALDHRPVHEVEQERAFEAPRKNSEYYKKKAKDKAINMLLNHIFPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLK9</accession>
    <name>A0A6A8FLK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000286">
        <property type="protein sequence ID" value="MRN69077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="202"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="312" mass="33731" checksum="89564C68E352E8DB" modified="2020-06-17" version="1">MIPVNEDLIVNAVQKVSRSVVNIASVRTVHDQLFRVFPVEGVGSGVIIDERCHVLTNNHVVDEAQKLKITLTDGSIFDGKVIGTDETTDLAVVKLDSTETLPFAALGNSDDLKIGQIVIAIGNPFALTGGPTVTAGIVSSLNRKIQFEKGVLELVQTDAAINPGNSGGPLINTKGEVIAINTAKMPYAHGIGFAVPTNIAKSVVTELIQNGRVINRPWIGISYVKITRQLAQYYRLPATEGVLIAQVELHSPADDAGLRKGDIIEAVDGKRIDDTTEISLNVRKKTLKDKLTMTINRYGRRFEVPIQLQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLR4</accession>
    <name>A0A6A8FLR4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplV</name>
        <name evidence="6" type="ORF">FIO04_07215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000511">
        <property type="protein sequence ID" value="MRN69473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="116" mass="13531" checksum="AEB37D9E4E0C9084" modified="2020-06-17" version="1" fragment="single">MPNYSYAFQQFDKTKHVRAALREKNISPKHSREVALAIKGSSIEKAREFLENVIAKRLAVPYRRYNNEVAHRSNIQDGFFAGRFPQKTAKEYLKLLDNLESNAEYKGMDLDRLRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLZ2</accession>
    <name>A0A6A8FLZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ilvD</name>
        <name evidence="16" type="ORF">FIO04_05100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="15"/>
    <dbReference type="EMBL" id="WJXC01000279">
        <property type="protein sequence ID" value="MRN69060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MRN69060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="503" mass="53425" checksum="564434DC9C40621C" modified="2020-06-17" version="1" fragment="single">DGVREAECTPREFTTISVSDVITQGHEGMKASLISREVIADSIELMVRAHKYDGVVGIGGCDKSLPGTLMAMARLNLPSIFVYGGTIMPGSWDGKQVTVQDVFEGVGMFETGKITLQELISLENVACPSAGSCAGMYTANTMASIGEAIGMSLPGSASPPAESDRRQEICHSSGKAIMNLLENNIRPKDIMTFEALENSIAIVNAIGGSTNAVLHLLAIAKEIGVKLVLKDFERIRKRTPHIADLRPGGLYVMLDLDKIGGIPVILNSLLKKGLIHADAMTVTGCTMKKNLESSNFSINILSAAPDQKIVRSVDNPIHKEGTLKILSGSLAPDGAVMKIASINTTKFAGKARVFEAEEDAFESISKEKVVEGDVVVIRYEGPKGGPGMREMLSVTAALVGQGLGEKVALVTDGRFSGATRGFMVGHIAPEAMAGGAIALVKNGDKIMIDTIKGKIDLLVSKSELNRRKKKWRPIKPHYAKGILAKYASLVSSASIGAITLPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMA1</accession>
    <name>A0A6A8FMA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA</name>
        <name evidence="3" type="ORF">FIO02_04875</name>
        <name evidence="4" type="ORF">FIO04_05655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000068">
        <property type="protein sequence ID" value="MRN40359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000330">
        <property type="protein sequence ID" value="MRN69170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN40359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="115" mass="12937" checksum="011D51FAF368F147" modified="2020-06-17" version="1">MSEEKKGTSMQALMELSEKNFDEIVSGTKPVLVDFWATWCGPCQFMLPIFDKLAKKYVDKVMFARLNVDDNQGVAMKFDVYAIPTFIIFMNGKAIDRAVGAVGEKGLEGLLQKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMF1</accession>
    <name>A0A6A8FMF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_01390</name>
        <name evidence="2" type="ORF">FIO03_01020</name>
        <name evidence="3" type="ORF">FIO04_05910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000011">
        <property type="protein sequence ID" value="MRN39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000017">
        <property type="protein sequence ID" value="MRN60623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000357">
        <property type="protein sequence ID" value="MRN69220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="115" mass="13302" checksum="DB5CA7206C1EFD71" modified="2020-06-17" version="1">MLYSNYLVLEDPLRYRINQITDSGINVSLTLSEDLELETVSQQQLMLESIDRVITDKEVKDQVRPILEAILSSQPQTLVKTYAETIVQITMPRRRYEKIGSPRVGEQLLIDIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMF7</accession>
    <name>A0A6A8FMF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urease accessory protein UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_06830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000463">
        <property type="protein sequence ID" value="MRN69397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="4">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="91" mass="10150" checksum="F3FA335627D6A3DB" modified="2020-06-17" version="1" fragment="single">FIYIIDVSGGDKYPRKRGLGIESCDLLVINKIDIAPYVGADLGVMERDAKIIRGSKPYVFVNCKDGQGTEEVTEHIIRDVLFEAPPKVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMK9</accession>
    <name>A0A6A8FMK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCA tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_06210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000387">
        <property type="protein sequence ID" value="MRN69280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA_NucTransf2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="288" mass="32475" checksum="FDC3E16AB3C36BC0" modified="2020-06-17" version="1" fragment="single">GIYGADIATGGFSGYVSEIMILKYGTFESVLHAMSNIGVENNVISIDKPDEYSIKNFESQLIIIDPIDHRRNLGTAISAESVGKLVLAARSFLAKPSFDFFIKNEKKFSGNYEGLYPNLVIIEFSYKRRSPDVIWGQLKRSLNAISKQLELANFKVIRSICVTDQLETAVFVFLLDSVTLSAYTEKIGPKIFMRKETANFILKNQKKSLITWVDSEMRVSTLIQRETTNAKHFLKLLLTKKIESTGITKGLKGDIQRLFRIYSGDDQKINGLAKEAVRDLITSDQRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FN76</accession>
    <name>A0A6A8FN76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tfb</name>
        <name evidence="2" type="ORF">FIO04_07150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000504">
        <property type="protein sequence ID" value="MRN69460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="41" mass="4575" checksum="D518A066AE708CCA" modified="2020-06-17" version="1" fragment="single">LYVACVMNGENKTQKDVAEAAGVTEVTIRNRYKGLKLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FN89</accession>
    <name>A0A6A8FN89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000510">
        <property type="protein sequence ID" value="MRN69470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="305" mass="34144" checksum="EE773A008E2A7772" modified="2020-06-17" version="1" fragment="single">MSLRERDYDIIVAGGGLAGMIVASSAAHYSNELLRILVVDRNPLSVMGKKTMTGWICGDAVGKKSVEYMSKRIGINWEYPEIEHPVKGVIAYSPNHKTAVSFDGEGYILNRKLLPQKQLKDAIERGIQVRDRVALRSLIIENNTVTGVEGEDLVNKSVFRKSAKVVIDCTGVTSVLRTNLRIKSFIQTRIDRDDLEATGRYIYDFDIASKDDTFFHPDYCIIHLDQKLAPGGYGWVFPKGENKVNIGVGVQQRAFDLRNKEMGLRRDLKMLIDEYVHINPVIGNPRVATSEIDDGNGWGTWSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNI1</accession>
    <name>A0A6A8FNI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000556">
        <property type="protein sequence ID" value="MRN69530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="14"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="25074" checksum="4E6ABB314067A74D" modified="2020-06-17" version="1" fragment="single">MIVQSIGKKMKTKLIGRQIYYYEELGSTQELAIYLAENNSEAVNGTAILAEHQDRGRGRINSKWISPSGGIWLSIILKPNMPANKSPLLKFIAALAVCDTIAQKTGLESKVKWPNDILINHKKVCGILLDIATKGSSIEYAVIGIGINANVNIRKILPYIPDYKGNDVSVTSLKNELSGKYVNRPSFLKLLFERLEHYYGYLEKEDLGGVVILNQIKDRLDILNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFG7</accession>
    <name>A0A6A8FFG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF424 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_01760</name>
        <name evidence="2" type="ORF">FIO03_02120</name>
        <name evidence="3" type="ORF">FIO04_00140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000015">
        <property type="protein sequence ID" value="MRN39759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000048">
        <property type="protein sequence ID" value="MRN60841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="109" mass="12390" checksum="0377FB0A5DFDC761" modified="2020-06-17" version="1">MSRIGAVGGKYAMRWMGYQGSTMVNICDLELIGTQIEQDKFVINLTKEYFQQEIIEDLVAEKLLLDCSIANLVGHRIVDRAIKLKLAKEASIKRISGVPFLMIYKFQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFP1</accession>
    <name>A0A6A8FFP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000021">
        <property type="protein sequence ID" value="MRN68205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="94" mass="10758" checksum="71C167DD9F536A8A" modified="2020-06-17" version="1">MIDCSEKIEDIRIKYSSCWNILDELNVDKSKVFVILSKSDNNVPQERINEIANDLQILNPLIISSKTGYGIRKLKTMIASNIVKLTIPKSKEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFT9</accession>
    <name>A0A6A8FFT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_03355</name>
        <name evidence="2" type="ORF">FIO03_01355</name>
        <name evidence="3" type="ORF">FIO04_00445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000039">
        <property type="protein sequence ID" value="MRN40066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000025">
        <property type="protein sequence ID" value="MRN60689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000011">
        <property type="protein sequence ID" value="MRN68151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="43" mass="5295" checksum="3530B36A1D54A5F9" modified="2020-06-17" version="1">MDRGVLSYRDTKRLRYYSQLFDTREVDSTFYDRFYSQMTKAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFY6</accession>
    <name>A0A6A8FFY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_01735</name>
        <name evidence="2" type="ORF">FIO04_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000035">
        <property type="protein sequence ID" value="MRN60764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000038">
        <property type="protein sequence ID" value="MRN68305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN60764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="65" mass="7681" checksum="C2074467732CE7B8" modified="2020-06-17" version="1">MSDGQSIKDIAQKFDNNEQMVSTWIGFLKYNRFIEEKEDSEENSIKLTISGIGRTWMRRYGFALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG68</accession>
    <name>A0A6A8FG68_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ORF">FIO04_01710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="WJXC01000055">
        <property type="protein sequence ID" value="MRN68395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="315" mass="34842" checksum="13B1868B20861F31" modified="2020-06-17" version="1">MMLEADYKHRVLSLKKEKNAVILAHNYQLPEVQDVADVIGDSLALSRTAAQSDADTIVFCGVHFMAETAAIICPDKQVLIPDPDAGCSLAASINARELKSWIAEHHDAVVVSYVNTSAEVKALSDYCCTSSNAVNVVNSIPSNREILFLPDMFLGSYVAKMTKRKNMYIWPGECHVHAGIKAQDINEMFQNFNNADFLVHPECGCTSTTLYHIATGELEKSAHILSTEGMMKHASASAAKQFVVATETGILYRMKKENPHKQFIPIKKDAICKYMKLINLEKIQNSLINNVYQVKVPPKTALKARAAIERMLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGN4</accession>
    <name>A0A6A8FGN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000107">
        <property type="protein sequence ID" value="MRN68595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="94" mass="10320" checksum="FFF8F6D319E64A0A" modified="2020-06-17" version="1" fragment="single">GLLDEQVREFASRKISESNLVVVLANLNSELDSMANVVFARSDSLFKIDCNQMFKEIASECGRGGGKSNFVTGVIRRENVGEFISTIVMMVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGV2</accession>
    <name>A0A6A8FGV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03020</name>
        <name evidence="2" type="ORF">FIO04_02065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000076">
        <property type="protein sequence ID" value="MRN61017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000071">
        <property type="protein sequence ID" value="MRN68464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="125" mass="14403" checksum="96B4D4C75D40375A" modified="2020-06-17" version="1">MSKPLIPGNAISFVRLLRQHSAKHAELADKRVDSAEELKQTDLRNTNLLLSNLNTQLMFVYSLLDITMTSLNDLENLIIEKNATKEEMDRFKTELNERIKDTLKPLREAFGIEEGRLKRAEDLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGW3</accession>
    <name>A0A6A8FGW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000132">
        <property type="protein sequence ID" value="MRN68675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="249" mass="28794" checksum="31F1666AC1CFC3AD" modified="2020-06-17" version="1">MEKISETDSTCVSTKTGENNPSRVTEFQDRKDMWLSTVEISKNLALDAQTQTTGELSFIRDFRNNDNKILSLLNQHTGSYYSFKGLMRKLNLHQQSLARALNRLEELGLIQRSVNGYKLNKNEQTSAKGMAMPDRLKRSEYKQLLQLYIPTGIKTEEIVQALNGRWFSRIRWIGLMESEIGYMLQWINEGDTFQINVRIIWDHLIIETNALSDEDKIEAMVGSCKIFEQITKLLQDHRVKALNSVRFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGZ0</accession>
    <name>A0A6A8FGZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000142">
        <property type="protein sequence ID" value="MRN68705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PTHR18896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="489" mass="55985" checksum="032B1C5DC032E33F" modified="2020-06-17" version="1" fragment="single">FTLMYEKIFKAKTSILIANYELDPRLRFIRGDSQSSSFINNNLPRSSSGFTSEPENIKLTHQNYTASPLQDLLFEKAKQGVEVKIIVWQPKLIIRLLPTAHKRGLSGRVGELEPLERLVQHSKITKNLMVRVDNTAPTFTSGHHEKFIVIDNKIGFCGGLDLSHGKWDTNSHDFDNPLRDQNAEPWHDVHAMVEGPVVTDLIYHFMQRWTYSITKDIDQAKRIKIEPSFENQNSTGDTEVIALRTWKQLNNKGDDNDGSNILSWYAAMFRKAKYSIYIENQFAFQSELITQLLVKRLQEEQNLKVIVVSPMEPNLPGFISGFVSKESINHVNRNLERLRKAGGSRVNTYCLISQHNAANEKRKQIYIHAKVMIVDDKWITIGSANMDNDGFKNSTEVDLGITSPVLAQQLRVKLWREHLTEEADSSNLSVDLNSFDEGFNAWKTLASDNGTRILRGERIRGQIYYYNFEEMKCPPPYASARGGNKFKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH80</accession>
    <name>A0A6A8FH80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000105">
        <property type="protein sequence ID" value="MRN68584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="171"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="319" mass="36226" checksum="20EB9177B846392B" modified="2020-06-17" version="1">MTESDCSELKFALRESVERNQCKALLLSGGLDSSILADILRPKQTFTVAWDNQAPDLPYARMVAHKYNTSHTELTLNNKNSLFHILRAVILGLKTFSPIDIRNSCVVYTGIMNAKKQGFSDIMTGDGGDELFAGYNYLNRYFMDVNRLDIELRRLWDIMHFSSISLAKTLDIEVKAPFLDDNFLNYAKTIPPAKKIGEFSGKMWGKFILRKCFLGELGGQIVWRPKLAQEEGAATVNLKHFLETQFNDIAFRSRAEQARAEGVIVRDKEHLYYYDVFRSYFCPPYKEYCSDARCPGCSGCVSAKTNYCRTCGAFPISPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHD4</accession>
    <name>A0A6A8FHD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_04105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000195">
        <property type="protein sequence ID" value="MRN68865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="318"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="418" mass="43826" checksum="57D80AFF262AC734" modified="2020-06-17" version="1">MNIKEIFILSFESLSDRKVRSILTILMVMVGSALLIAVGGIGASFTDAFSKQFRNLAPNILFISSSQQAQEGPGGGVGGAGTPPPAPKITLNAAIVNRIHSLPFVSDVISTYRGSVTVQSQSESKTDSILSMDPQKLIVIAPTLEYTDGSTLQPNNPASMIVAQNVANPPGDANPFLVLGQSAKVTYSFVDSTTGQQKEESKNFIVTGIIKETGNPTIDSAIVINPQAGNSLLQKSGKFDSLFAIAQTTNFVDVVEQEIRSLYGNNIGITTVKAILKTIEQFTGQIKAFLNSIAIISLVVGAVGIITTLYTAVIERTREIGTLKAIGAQNSDILALFLVEALLIGIFGATIGLLAGIGFGYGLSATVVPGNGSSSPPIYTANDMARVWMISVGLSIVAGVVPALQASRLLPVQALRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHE6</accession>
    <name>A0A6A8FHE6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="6">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">aspS</name>
        <name evidence="8" type="ORF">FIO04_00740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000021">
        <property type="protein sequence ID" value="MRN68208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="149"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="417"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="446" mass="51383" checksum="9396F0382B2F5474" modified="2020-06-17" version="1">MSDLLHEEEIGQWRRTHYSSEINSSLEDREVIIMGWVSSKRDHGNIQFIIVRDRYGDIQVMAKKSECSKRLFGQIQQIKEHTSLAIRGTVRPQEKAPNGVEIIPLELKAFSIARKAAPFMMQSKTSIGIDTRLDLRAIDLRRNILQSIFHIRYTVLNASREFLARQGFIEVNTPKMIATATEGGAALFPIFYYDREAFLAQSPQLYKEQLTMAFENVFEIGPIFRAEPSRTNRHLSEAISIDVEKAFVDYNDVMSLLERMILHVLDSVKEKNKNDLAYLEFQLPNIELPFARYSYSDLIEQLQGGGERIRWGDDLSPQAMKNLPDDRMNGFYFITDWPTSIKPFYVKPKFMPESGRVSESFDLMYGPLEISSGSTRVNRKDELLERMKKQGLNTQAFDYHLKVFDYGVPPHAGFGVGLERLMMAITKIDNIRDASLYPRDIDRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHF7</accession>
    <name>A0A6A8FHF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000126">
        <property type="protein sequence ID" value="MRN68654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="72" mass="8003" checksum="50691CE3A5184E93" modified="2020-06-17" version="1">MPVKYAVTITSIGTSSFIVIPKPVIDGFNLRKGQRLDLIVNDDGIRIPLLDQRTTDGKDFPTHLEKGDISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHG1</accession>
    <name>A0A6A8FHG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_08415</name>
        <name evidence="3" type="ORF">FIO04_03115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000378">
        <property type="protein sequence ID" value="MRN62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000131">
        <property type="protein sequence ID" value="MRN68671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="142" mass="16089" checksum="765349E99D59BD40" modified="2020-06-17" version="1">MSDDIYREIILDHYRNPRNKGRLPNPDVSIHDSNPLCGDEIDMHLKVEEDKIKDIKFEGRGCAISQASASMLTEMVLNKPLKHVKDLVKEDILENIGLTNLGPARIKCALLSLKVLKMSMVKYYADRDPESASKYENEPGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHS4</accession>
    <name>A0A6A8FHS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000253">
        <property type="protein sequence ID" value="MRN69005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="81" mass="9217" checksum="F8FEAE96635BB2A3" modified="2020-06-17" version="1">MSTSSNVDTRRIGSFNEERFPKPYLELRKDTAVVDLSFSLPENDEHLKKAFENHYQESTSRDILSSNGQTKTCTVIKSFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHS9</accession>
    <name>A0A6A8FHS9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_00235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="253"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="504" mass="57461" checksum="01BBA7F4D77C44EE" modified="2020-06-17" version="1">MTNSNTDSPLHPLEKSILEALVGRNRQSIEELAKDTRLGIDQIRRGIEWLKLKGLIHLDEMSSISLGTSGYQAIKQGLPERRLVDYLKNGKNRIQEISNSGFFSQKESHSAFRYAKQNNWIEQQRDSIGEKRLVRMLAADNKSAEEKLLNKLGEQENLKMSDLTSEEMNAFNSLKSRDPGYVREDKLPNETTVTLLEPGKRALSSVAEAGLMVEVLTQRMAPTGKFKSVNLPPMDVQAPVRSLFPGRKHPIANLIDEISEIFVGLGFTEIEGPITQSSFWNFDALFTPQDHPAREIQDTFYLAQIKQDKFATEDQVHKISSAHKDGWKYEWNIDDAKGIVLRTHTTAVTIKYLADNKPENARIFSIGRVFRNEKVSYKHLAEFTQIEGIVTGSRVSLQDLMGLQLEFYARLGIKKIKFWPTFFPYTEPSLQSMIYNEKLEKWVELFGMGVFRPQVTKALGIHNPVLAWGGGLERIAMLRFGLTDVRDLYENKLGWLRSIPRCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHT2</accession>
    <name>A0A6A8FHT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="5" type="ORF">FIO02_09035</name>
        <name evidence="6" type="ORF">FIO04_03800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000209">
        <property type="protein sequence ID" value="MRN41172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000175">
        <property type="protein sequence ID" value="MRN68804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN41172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="258" mass="28423" checksum="3352F5697F1AD75A" modified="2020-06-17" version="1">MSFLEAKDLHASIEGKEILTGLNLVINKGEVHALMGPNGSGKSTFANVLLGHPKYSVTSGDILVKGQSLLNLSTDERARKGIFLGFQYPIEIAGVGYSHFLRNAYNTLTKTLAEEQKNREVFLTVREFHEYVKRNLDSVGLDPAFLSRYLNEGFSGGEKKRSEVMQMLVLKPNVAILDEPDSGLDIDAVKSVAEAINKLIDTGAGVVVITHYARILRYLSRLDHVNVMAKGRIIKSGDKGLSEELETKGYGWLGLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHU0</accession>
    <name>A0A6A8FHU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_00285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000006">
        <property type="protein sequence ID" value="MRN68119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="27"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="354" mass="40487" checksum="C0E2EA30F385E16C" modified="2020-06-17" version="1">MTNWLSDRLDKICKLDAYVKPERIKDSIKLDANENFALDSKFISKIALHAIKQTDLREYPLEQFEDLYRQLSNYSGVDKKYLGIGSGSDQIIELILSIFGRNQQASIFTPTFSYFINRCELHDIALDRVPLTRDAELPKLEFLKRAARSDIIYICSPNNPTGNQFGEKLVLEIIDTFKDKLILIDEAYVEFGNYNLAPHIAKYDNVVILRTLSKAFGLAGARIGYLIANEKFAEIFRTTIQSPYPLNSFSLAVATLALSYERYVRQTVELIKRERKRVFDELFEMNGIKVFRSDANFIFLESYDSYGRILSVLKKEGLSVKAFGDIDGHRGCIRVTIGTSEMNDKFLKSISKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHU3</accession>
    <name>A0A6A8FHU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000049">
        <property type="protein sequence ID" value="MRN68358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="54" mass="5971" checksum="DCA002110F36919C" modified="2020-06-17" version="1">MSRAMLSYDKGTISIQGVAHIPYSNLDPHTNMLRAVALYSKNSLDYLANVNLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHU6</accession>
    <name>A0A6A8FHU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_03240</name>
        <name evidence="2" type="ORF">FIO03_02645</name>
        <name evidence="3" type="ORF">FIO04_00335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000037">
        <property type="protein sequence ID" value="MRN40044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000064">
        <property type="protein sequence ID" value="MRN60942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000008">
        <property type="protein sequence ID" value="MRN68129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="105" mass="11902" checksum="3A5968320DA4C022" modified="2020-06-17" version="1">MQYHKAAFLGQERAKKAQMKLFDYAGFAMLTYTIKQSDKGFEPVGEEMLAGKIARGDEAMLFICDKDGYAKAQSKPLPMQKSEEIYRKMITDGIQEFMGMIKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHV4</accession>
    <name>A0A6A8FHV4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">prf1</name>
        <name evidence="11" type="ORF">FIO04_01570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000051">
        <property type="protein sequence ID" value="MRN68368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="435" mass="48745" checksum="78E38D388EC5CD3D" modified="2020-06-17" version="1">MNNGSSSTQPKWDSVKRYKLTKMLNELGSISGHGTELVTVYVPPRRPIFDVIAQLRNESGTASNIKSDLTRTHVQDALSRTIEHLKLFKETPENGLVIFCGAIPSGKGFGTEKIELYPVLPPKPVQIQLYRCDDHFWIDHLRDMMKDDKVIGIIAIDTQEAGLGILTGDRWVVVDTMTSGVAGKHRQGGQSARRFERLRDNELNEYYHRVGDHAQKVFIDQFNVRGLIVGGPGPTKENFLREEYLDYRLQNNVITTLDTSYSGDEGIREIIDKVNDQGVMTEYRLMEEKKIVKKFMGEVHSGRGLGIYGILDVIKSLQNGIVDLVIVTDDITFLKLDVKCKRCGTIQEKFIERSNLVSTKQELLSKPCPSCSAVDYESSEKDIVDYLEELATMTASRLEIISGKSEEGAQIASLGRIGAILRFRPSSSNTIARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI04</accession>
    <name>A0A6A8FI04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_00640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000018">
        <property type="protein sequence ID" value="MRN68189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="11"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="522" mass="56783" checksum="CA09EAB08FD04ED1" modified="2020-06-17" version="1">MDLTINYKWTALSNTTIGTLMASLDTNIIIIALPTIVSDIHVSLLTLVWIVLGYSLVTASILLNLGRLSDMLGRVKLYNIGFIIFTIGSALCSLSQTGEQLLLFRIAQSLGAAFLFSNSAAIITDAFPENERGEALGINQISIVVGSVMGLIFGGLLTSYLGWRSIFWINIPIGVFATIWSHTKLRELGTIKKEQIDWIGNATLAVGLSLILVGITFGSFQILNNIPFGMYLFVIVGLSLIGLFVFVERNVIKPMIDLSLFRIRSFLGGNIAIFFNAIARGAFILIMTFYLQGPTMKLSPLDAGIYLLPVSIALSIFGPFSGWISDRYGSRVISSIGLFISAIGFFMLTSLSTKSTFIETLLPLAMIGAGMGIFASPNRASIMNSVPRYQRGVAAGTSTMFVLSGSTLSVGLAFLIMSHTMPLNYIESIFLGTTEITTKDSIKSNNNSNNNNNTNNQNQVQNGNNNNVKITMTLLHSTTIINNFLSSLHYVFLLSAMLMLISIIPVCISAGNKRDNHNIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI10</accession>
    <name>A0A6A8FI10_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP cyclohydrolase I</fullName>
            <shortName evidence="3">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">folE</name>
        <name evidence="5" type="ORF">FIO04_04135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000197">
        <property type="protein sequence ID" value="MRN68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="4">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="200" mass="23011" checksum="13E6D540A1EC7D6B" modified="2020-06-17" version="1">MQPDEKINIEKVDTIHKEKIEKLLRQLLIEIGENPDREGLIGTPARMAEMYEEIFGGYKINSELDVSFTEAAETIIAKDIQFYSMCEHHMLPFFGKIHIAYVPAGKVFGISKLIRLVEKYARRMQIQERLTKEIADEVMRRGVKGVLVIAEGEHLCMKMRGVRNGSLILTEAHRGIMEQKEIREHVLSLIYTSKPELQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI12</accession>
    <name>A0A6A8FI12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000202">
        <property type="protein sequence ID" value="MRN68884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="124" mass="14224" checksum="D9BB70C8F892774F" modified="2020-06-17" version="1">MGKQQNNVIEFSEKESKYLKEQRLGRIATVSPDVQPHVVPVAFEFDGSHFYFGGWNLEKSLKFRNIRQNNKVAFVVDDLVSVDPWRVSGVEIKGIAEINKRNGNEYVKITPLRKSSWGLEGRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI30</accession>
    <name>A0A6A8FI30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000209">
        <property type="protein sequence ID" value="MRN68904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="9"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="381" mass="42130" checksum="DCA9AFC2A2878C89" modified="2020-06-17" version="1">MEYLVMLPGPTNVPDRVMNAMLTHIINHRSDDFRRLYKTIVEKTQRVFQTQNDIVLLTTSGTGAVEASVINMIRKNDKAIIPVNGEFGTRLADLIDSWGGHAIRVTAPFGQNPQYSEIEDAFDRNKDIKAIYAVYNETSTGTTLRYMDKLSQLCSERGAFFIADAVSILGGDELPVDKWNVDICVTASQKALAAPPGVAPMSISARAKKHMQANPPPTQYLNLKRYFKYYEENFETPFTPALPLFNAFSEALDMVLEEGLDKRIARHKACADAFYAGLDAMGLSPFARQDARSNVVIAINYIPGMDDKKFRGLLSQQFRILVAGGFGDLKGKVFRIGSMGEVSKYHVMRTLSSIASVMNILGLKVSPDAGSIALKKLESVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI50</accession>
    <name>A0A6A8FI50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_00845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000025">
        <property type="protein sequence ID" value="MRN68229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="PTHR12636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="233" mass="26331" checksum="CB599FB49EADB325" modified="2020-06-17" version="1">MALVIAEASLETVPKQILRHMSVLRHAQKLGKKPSEVLLDRSYHHSAMVTGRLESVWKRGRPDIVHFALVEALSTPLYLKNKLAVYVYTINSQVILIGANLRIPKSYFRFEGLMMKLFKDKVIKSEQDDRILLELLDDVPFKHLIKNIARSSKSIGLSSGGVSSTAYEVVSKYIDRFDDCRCAIVIGGFPKGRFSDNISNFLDNSYSIGKITLEAHVVIARILYECEKILFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI85</accession>
    <name>A0A6A8FI85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C(20)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.130</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobI</name>
        <name evidence="9" type="ORF">FIO04_04665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.130" evidence="9"/>
    <dbReference type="EMBL" id="WJXC01000238">
        <property type="protein sequence ID" value="MRN68974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="243" mass="26921" checksum="41955D3BF9EED68B" modified="2020-06-17" version="1">MKLFCVGCGPGDPELLTVKAVNIVKAADVIFAPTARDGKPSIALSVVERHLKKSARTVSLVFPMTKERESLRDYWKRNALEIADAVRSDKKVVYLTVGDPALYSTWIYIHRELVCNHEDIEIEIVPGVASMFAFAAQAKMSLAEGDETVAIIPACYDLNRIKKVANSCDTLIFLKDGRYFDRVIEMLSEAGFGDDSAIAIAQDVSVEGEILKMNKLSDMVGTKGPTEKYFSIMVAKKKNHDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI98</accession>
    <name>A0A6A8FI98_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_05630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000328">
        <property type="protein sequence ID" value="MRN69165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="7">
        <location>
            <begin position="49"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="319" mass="36002" checksum="B0C5BEE0D1E10B65" modified="2020-06-17" version="1" fragment="single">YNHVEKQAYYFSIRPNSRIKEVKDLMSESRALQEESTFSYSTPERNLTRKQFIEKVNKSKKYIYDGDVFQVVLSKRMTFKISGDLLTVYEKLRDINPSPYMYFFRMGGKHIIGSSPEMLLRVTGDHLETFPIAGTRPVADDDKRNQQLSKDLLNDEKEVAEHTMLVDLARNDIGKVSKYGTVQVKELMKVKRFSHVQHMISHVTGILQSGFDSYDAFRALFPAGTVSGAPKLRAMEIIDELEPNFRGPYAGALGYFSTNGSCDFAITIRSIFANKSDAFIQSGAGIVMDSIPQTEWAETEQKANALLSALEKSKATSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIB0</accession>
    <name>A0A6A8FIB0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase</fullName>
            <shortName evidence="1">LP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">cofC</name>
        <name evidence="2" type="ORF">FIO04_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63424"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:59435"/>
            <dbReference type="ChEBI" id="CHEBI:59906"/>
            <dbReference type="EC" id="2.7.7.68"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.68" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000237">
        <property type="protein sequence ID" value="MRN68971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="224" mass="24864" checksum="56B2B4FA05BEBCBB" modified="2020-06-17" version="1">MKIFALVPVKKFESSKSRLGAVLSINERIKLSELLLINTISVLKKSSAISNIVVVSSDERAMEIARRTDAKFLKEAKDRGVNAAIAVADDYSSENRAHASIVIPVDLPLLTATDVNMMCRKAKSPERCLVISPSIRYDGSNALLRKPSRLLKTHYDDDSFNAHIRAATQFGIPIKVFLSQRIMKDLDSIEDIKILMNQRVTNPPVAYLKSKVRTSLLASDPTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIB5</accession>
    <name>A0A6A8FIB5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_03290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000142">
        <property type="protein sequence ID" value="MRN68706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="SSF118310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="257" mass="28998" checksum="CF1EC602EC0083D7" modified="2020-06-17" version="1">MRCNTCGLEESIPFRCNYCGESFCHLHRIPINHSCPFINKYAEKRRLMMQGNYDDGPAASSFSNSIGKSLLRAIKIKSSKTELLHLFIATLLITAVGLSFNDYRYISWQFLAIFISAFLVHELAHKFLAQYYGSWAEFRAQLYGLIVTAISALPIMPFKFIAPGAVMVGLSDRNKFGRVALVGPLTNLVMGFSFLISTYLYPHHSYLYAGASFNAWIAMFNLLPFGVLDGQKIFDWNKIVWGCAMATTMVLFITAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FID7</accession>
    <name>A0A6A8FID7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000096">
        <property type="protein sequence ID" value="MRN68558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="481" mass="53279" checksum="14E2817FA7B8E021" modified="2020-06-17" version="1">MVKGLQFSLFSVKHLSEKIKTNEISPVDLIEFCFDRIRKFNPSLNAFITVIDEEDAYNNARIAEREISQGNYRGPLHGIPFSIKDIIYAKDIRCTGGSKILSEYIPKTDATCVKKIKEAGAILLGTNNLNEFASGITGVNPFYGNTKNPWNMSRISGGSSGGSAVAVSTGMACISLGTDTGGSIRVPSSLCGVVGLKPTYGRVSKYGVVPLAPSLDHVGCVTRSAWDAAAILECISGWDSSDHISNHKKVPPYTKIIETSNFGGISIGVPKDYFFDYVHPEVESLFYQFLESIKSLGYKVFDLDLQNTERYYNTWRKIRYAEASEIHAHWLKTRKEDYSEEVREMLIQGTKISAVDYIHAMRIINEELKKEILAMLRHKIEIIAVPTTIIPAPRFDELTVSDICGTVLQTREALLRNTIVFNSTGFPAVSIPIGLTKDNMPVAVQMIGPPFREEKILSVACNYECINSTGIKFMPPSPFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE9</accession>
    <name>A0A6A8FIE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000153">
        <property type="protein sequence ID" value="MRN68736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="88" mass="10095" checksum="2532D4E35A26953B" modified="2020-06-17" version="1">MSTPIESKEGRAVWSSDEEGHKRMIYPEEKQQGHKITVSEHAYVILLNMAEDSHDKQVTEEAKNDDFSTLLTAMLVYTRNDNVSELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIF0</accession>
    <name>A0A6A8FIF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000265">
        <property type="protein sequence ID" value="MRN69034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="214" mass="22602" checksum="24039ADB0B164C0D" modified="2020-06-17" version="1">MNDPKVARGNDTSTKKTIAALFVFGTIIAFPLAISDMPAFAIGTNSTTSGTAGTSMMKLTTPNAPVVIPLVKGLYDGKDILLITTEVSDKAMKDQIGNFTGSPVNYEPNLTKSQDIGNLWIFKNGVKGPGFMGFQASVVDSIPGDSHYTPLWKVSIVEWKTTSGTTPTILGSDNAIATAQSKGQITITPTKVVVNCPILQWGGNKDNTILAGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIG9</accession>
    <name>A0A6A8FIG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000100">
        <property type="protein sequence ID" value="MRN68572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="105"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="289" mass="33990" checksum="E349555F462A60C6" modified="2020-06-17" version="1">MTISFNPEISINSGQMFLWEQIGNSWYGTYGDHIIKFSTSWTNNQFYSYPEVKGWERKVFRLDDDIEKILSTLSNDTLVSKTIRRYPGLRLMRQEPYQCIFSFVCASNTNILMIRKMLKNLSKKFGCKVIFDGKEFYTFPSVNSLNKATINELHSCGVGYRAKAIKALANHIVSGNLDIDYLIRIRYYDAKEELLKVYGIGNKIADCILLFSLEKLDAFPIDVWILRALSRYYSWLFNENENKFKMTERITINQYKVLSATIRNYFGKYSGYAQQYIFYYMREIAGKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIJ3</accession>
    <name>A0A6A8FIJ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ORF">FIO04_02850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000115">
        <property type="protein sequence ID" value="MRN68618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="71"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="105"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="349" mass="37731" checksum="2FE2A2DC12A9D654" modified="2020-06-17" version="1">MVRKLVSRINLSEDEIRKSMNLILGGDASESSIASFLVALRMKGESPKEITTILQAVKRNAIKITPNITGELIDTCGTGGDKIKSFNISTAAALIACAAGCKVAKHGNRSVSGFCGSADFLEFIGMDLDTSPDIICEAIENIGFGFLYAAKFHPAMRNVASARESIGIRTAFNIVGPLSNPCTNLSGQLIGVYEPALLETVAVAMQNSELDELMVVHSYDGFDELSNTCENDIIWVVDKKIQRFRFHPKDVNVLVAKPEQLLIHSGQESIRDTLRVIYGLASPEKEDIAALNAAAALVIGKIAKDLKEGVEIARAALKAGTPQKKLSELIHLCGNKDKLIEAEQEFLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIL9</accession>
    <name>A0A6A8FIL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_07190</name>
        <name evidence="2" type="ORF">FIO03_05850</name>
        <name evidence="3" type="ORF">FIO04_05255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000132">
        <property type="protein sequence ID" value="MRN40810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000203">
        <property type="protein sequence ID" value="MRN61559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000293">
        <property type="protein sequence ID" value="MRN69091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="73" mass="8108" checksum="842E42F0D9776D26" modified="2020-06-17" version="1">MVVLILLVEDVLLGEDDDANTAAVNSDDENTAMAMPKINIVVVTNKIFVIKDEYNIPNMWWVMFGGLGVTSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM6</accession>
    <name>A0A6A8FIM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000054">
        <property type="protein sequence ID" value="MRN68389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT_7" evidence="1">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="233" mass="25995" checksum="5653D8ACB96358BF" modified="2020-06-17" version="1">MSVNGKSITHAVKEVINNDLSFQDSLERGYCNISAVARIIRPQVNRLLGRNIRIESIITALKRSRKLYDIPVRPMLTILANSTISVKTDVAKISTGKSKRSIEKVAKALTQYGDNFISVSESILSTTIVFDDTLLHEVKGIFANYNILEVEDDLAAIIVNSPEQIIKTPGCAIAFYNQLARRHINIEDTVSCYTDTIILVKMTDVGKAFNALTELISSSRKFPKTDNKILKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIP5</accession>
    <name>A0A6A8FIP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000398">
        <property type="protein sequence ID" value="MRN69295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="HYPK_UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="12449" checksum="6416DCF337398F2E" modified="2020-06-17" version="1" fragment="single">MMRGGNREMRRMLDKMGLEMKDIGNVEEVIIKTESKELYLLKPQVIEMKGKESTIFQVIASEIEEKERDVPTFKEEDIVLVIQQANVSREKAIQALIDAHGDMAQAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIR3</accession>
    <name>A0A6A8FIR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000063">
        <property type="protein sequence ID" value="MRN68429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="24371" checksum="533A9E8F08A1AB24" modified="2020-06-17" version="1" fragment="single">MVTYDIAVVGGGPAGLSAAYAAAKAGGKVILLEKDESIAHSIRTSGVTWIDEIEKLGIGSEYYNPIKNYSFISSSNEVTIRGITPKACVLNVRSTYQHLAMLAAEAGAEIMVRSRVTNVVTTPEDRRICGLKAKTPKGETVIDCKVVIDASGFSSSIARCLGIVKEWRRYGIGAEYECYCENLDHETWVLMVGTKYSEAGYAWIFPVSKNKARIGVGVGRPESYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIT7</accession>
    <name>A0A6A8FIT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000070">
        <property type="protein sequence ID" value="MRN68459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="68" mass="7686" checksum="53585D3607414796" modified="2020-06-17" version="1">MIRISLQTLIIIWWLGAVTAAISLLIPLYSAYLLIGSIGWTVVLSTTALIIYEIKRIKEEDKKKQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX5</accession>
    <name>A0A6A8FIX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000161">
        <property type="protein sequence ID" value="MRN68758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="123" mass="14206" checksum="601D97E1187300FD" modified="2020-06-17" version="1">MFSEIPESTVVKCRVLLNIERFEIGQSYVTAKVQNRYGDKVTINIQGGRPGIELQESLFKIKDQDRGGSPRYAYLLTKLIQTKKILVRKLPVIGMRDWLLIYEDTLVELSVKDEYDELEIVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ2</accession>
    <name>A0A6A8FIZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NosD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000363">
        <property type="protein sequence ID" value="MRN69234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NosD" evidence="2">
        <location>
            <begin position="51"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="252" mass="25629" checksum="A185E1D686F67B8E" modified="2020-06-17" version="1">MAQTQTQQTTSPSVASTPKSSSASTAAITPITNPACGEVVQGNVNLTANLNCTGDGLIVGADNTVINLNGYTVSGPGQQSSKVGVVVPNNDNVMVTGPGVIKGFQAGILATGSNNVQIKSIILTGNEIAVFTTGSTNTQVQENIIKNNNLGVASHSSKGASLMSNLITGNELAGVTLVNTHKAIIAANNIEGGQNGLFLDAQSSENTINMNNVLHNVIDLNNANGLAPNINVNSFADNNCMVSNPSGLCIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ04</accession>
    <name>A0A6A8FJ04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_06970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000484">
        <property type="protein sequence ID" value="MRN69425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="34"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="257" mass="28276" checksum="3007066F7EB73D39" modified="2020-06-17" version="1">MALDTNNGSNINNNNSHPSNDGNHDFDVSSDATLAVENLSKVFESAAGRVVALRRINITVNKGEFVSIVGPSGSGKSTLLNILGALDRPSFGKLFIGGIDIFSLSDKEIARMRNNLIGFIFQSYNLINRTTVQRNVEIPSIIARMSSKERANRSSRLLEILGIATKAKFKPASLSGGQQQRVAIARSLMNNPTIILADEPTGNLDTKTGNEVFDLLRLLSIKYRRTIIMVTHNAELAKKTDRSIYIRDGQIEKEILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ05</accession>
    <name>A0A6A8FJ05_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">sat</name>
        <name evidence="10" type="ORF">FIO04_00580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000016">
        <property type="protein sequence ID" value="MRN68177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="9">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="8">
        <location>
            <begin position="167"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="382" mass="43529" checksum="D52D22D19C726507" modified="2020-06-17" version="1">MTNVSSIPRPHGGKLINRFASTKKNIDGVFSIEVNNDLRNDIENIADGIFSPLEGFVGQDDFQGIVKSGRLTNGLAWTIPIILDVDDETASQMKDAGEVVLRTGNEHFGVIDVEEIYSYDKTSVARAIYQTNDLRHPGVMKVIGLKDRLIGGNIQVLMRIPQSPLRRFRMNPFETRSEIQKRGWKTVVGFQTRNVPHVAHEMLQKTAMNIYDGLFVNPLIGKKKSGDFKDEVIVSTYETLIENYYPKSRTMFGTLHTEMRYAGPKEAIHHAIMRKNFGCSHFIIGRDHAGVRDYYDPFAAHDIFSDYPDLEIEPLFFPSFYYCNKCLSYANERNCPHGSEFREELSGTKMRKMVSCGEIPAEHLMRPEISKLIKSYKEPFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ08</accession>
    <name>A0A6A8FJ08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_06015</name>
        <name evidence="2" type="ORF">FIO04_02395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000097">
        <property type="protein sequence ID" value="MRN40582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000088">
        <property type="protein sequence ID" value="MRN68529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="120" mass="13741" checksum="A42DCA5CEEBE0989" modified="2020-06-17" version="1">MEYTKLCESIFALHDDIRYAAVVDDTGLQIAGGMRRGIDSIVDQTNEELYLTQTALRKSMRQRFDDTMGNARFAYVEREKISILTFYLNKNILIVTMESNIDSHSAIDIAEDTLELLRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ42</accession>
    <name>A0A6A8FJ42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000507">
        <property type="protein sequence ID" value="MRN69465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="252" mass="26452" checksum="D8237FB1223C9238" modified="2020-06-17" version="1">MLQLSIRAFPALIICFLIVLVVLSQNVLIKLASAHITKKFGSIQVQVGWRDEPPLTGQLNSVIFDVNQTSGKTQTPIINALANMNILVKYGGVTKSLDFLPSPTTDGLYLGKMIPSRVGSYYVVLNGTIQGQKISSQLPLDLVDSSQKLAFPDTVTGSGTDATVTGGSASTSTNTNNIGPQLQGIVSQLANQIDSVKSVIGSVAKSNADTMKSVQDVKSAADRSYLIGMVGIGAGISGIVIASLALSRKRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ45</accession>
    <name>A0A6A8FJ45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000096">
        <property type="protein sequence ID" value="MRN68559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="102" mass="10572" checksum="FB2297C5729853D5" modified="2020-06-17" version="1" fragment="single">MKIRETTTIIGVLFGTMLVMSGVGLTNTILVNETFAATAPGNMTNATNTTNPQAAVQKGTTSSSNDVTTTTTNNNITLGNPFYIEYDKITSTVPGIPLNGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ48</accession>
    <name>A0A6A8FJ48_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000225">
        <property type="protein sequence ID" value="MRN68936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="76" mass="8884" checksum="528227AC67D0BF21" modified="2020-06-17" version="1">MTAKVCNSYRGYDSTLRAWEAILLLLELTYMDLYLIHWPVPDMRDEICGVMVGLYDEKARAIRVSNYDIPDLKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ83</accession>
    <name>A0A6A8FJ83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO02_05505</name>
        <name evidence="7" type="ORF">FIO04_01045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000084">
        <property type="protein sequence ID" value="MRN40482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000031">
        <property type="protein sequence ID" value="MRN68267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN40482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="306" mass="32305" checksum="D0563FDCB8F3E6DF" modified="2020-06-17" version="1">MMEYWQLLLLGSIAGFTIFLGLPLAVLQNVNPKKKGFLNAFAIGILVFLIIDVFGHAWQSVGIAAQGAFAGKSPLGNAVFDLLAMFGGLAIGLLGLVFYESRYMMSKSGHNSTATMKSFLRNRQEASAKDVVKDGSGNKASDGSQQEQHLLLQEINAYKLSTMIAIGIGAHNFSEGLAIGQSYISGAIGLAILLIIGFGSHNATEGFGIAGPLTGLVRKPRIRFLIMAGLIGGGPTFVGTIVGSFWNSTIAYVLFLSMAGGALVYVSMLMYNSGRRQTTNNIMMVGIFVGLCTGFVTDLIVTLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA8</accession>
    <name>A0A6A8FJA8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="8">DHOD</shortName>
            <shortName evidence="8">DHODase</shortName>
            <shortName evidence="8">DHOdehase</shortName>
            <ecNumber evidence="8">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pyrD</name>
        <name evidence="10" type="ORF">FIO04_01145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="8">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="WJXC01000035">
        <property type="protein sequence ID" value="MRN68287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="9">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="278"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="318" mass="33967" checksum="EC03DDB1C656023A" modified="2020-06-17" version="1">MLEWCKLLRGKRQREHDRTLSINIAGMELRNPTMLASGFLGISQAIFNRLYNADVGAIVSKSISCEPMEGYRNPTAVCLEGGSYLNAVGLANPGADAFSSEIASNPYVPIIVSLVGSSHDDFPKIINKFDDLNILGYEINLSCPHVAKMGMEVGDDPDMVTKVVKTVKSHTLKPVVVKVGIGNVDLLDIARAANDAGANAITAINTIRAMTIDIESGIPVLSNKIGGLSGKSVKPIAIRCVYEISKNVGVPVIGCGGIFSWEDAVEFMLAGASAIQLGSVIGYEGFGAFQKISLGLKRYLERKGLKNPTELVGLAHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB9</accession>
    <name>A0A6A8FJB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000211">
        <property type="protein sequence ID" value="MRN68908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="65" mass="7391" checksum="86104FBC2B3618D1" modified="2020-06-17" version="1">MDEDKTGLNRREQLVLALDNSRKKIKGYCMALYKISINNAATLSEILERPKSKSDSPGATRKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH1</accession>
    <name>A0A6A8FJH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000133">
        <property type="protein sequence ID" value="MRN68679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="172" mass="19734" checksum="DE896C541623D776" modified="2020-06-17" version="1">MNESPPSSDEVRIRLKHRDWEVEISCIEKKVKEVVENVLSGIDSSVSINSEFSTQIAELRRQIDTLTEQVHSNVIIQRQMTNPVTLQNKMAQRGGITCRGLLQSLFAEGYFGTEKPLGEVHEELSRRGFNYDRTAVSHSLTDMVRENILTRKGTMRNYQYIQRKPPSESPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJI7</accession>
    <name>A0A6A8FJI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_06025</name>
        <name evidence="2" type="ORF">FIO04_05230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000097">
        <property type="protein sequence ID" value="MRN40584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000291">
        <property type="protein sequence ID" value="MRN69086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="233" mass="26738" checksum="818814C4B8756514" modified="2020-06-17" version="1">MRGSKALVMLSGGLDSATCLYWAKEKFSDVSAITFNCYDRIQKEKESAAQLAKRASISNFLEIDIPFIKEYSDLQIGNRQKSDSRWPSYVPARNLIFYSIAAHYAEFLNIKWIVGGHNSHDGSFFKDATKKYIEKINSLFKHGCLLSNHDPCVIVTPLSKMDRKHIINLAIDLKVPLEVTWSCHTKARRHCGECYACKQRLDAFRSLGMKDPVFFRNSKKYHHRLHATQSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJK5</accession>
    <name>A0A6A8FJK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_09805</name>
        <name evidence="3" type="ORF">FIO03_04380</name>
        <name evidence="4" type="ORF">FIO04_04705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000241">
        <property type="protein sequence ID" value="MRN41319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000129">
        <property type="protein sequence ID" value="MRN61277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000243">
        <property type="protein sequence ID" value="MRN68982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="54" mass="6329" checksum="71CB1E48057991AD" modified="2020-06-17" version="1">MYLVIHNALVTEVNKGPVKIVIYSHTHMDHIGTASMFPRNATYITQHHFREYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL4</accession>
    <name>A0A6A8FJL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000247">
        <property type="protein sequence ID" value="MRN68992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="191" mass="21473" checksum="FF3ECBDC88959527" modified="2020-06-17" version="1" fragment="single">AKGQVIIDGIDIYDRNIDPVIIKRRIGMVFQKPNPFPTMSIYDNVVAGLKLNGIRDKRLMDEIVKDSLEGAALWDEVKNELGKPGMGLSGGQQQRLCIARALAMQPEVLLMDEPTSALDPIASSKIEDLVHDLKKRFTVIIVTHNMQQAARVSDYTAFMYLGEVIEYSPTKKMFENPEKELTERYISGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL9</accession>
    <name>A0A6A8FJL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000057">
        <property type="protein sequence ID" value="MRN68407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="70"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="193" mass="21210" checksum="5C1BE44949D22266" modified="2020-06-17" version="1" fragment="single">MGIIQSLQCRECRKEYEPQFRYVCEECFGPLDVTYKFPSSIKKNSFESREKNYWRYFELLPIADKNNIVSLNAGFTPLQQADRLGTHLGGMKNLFIKNDSVNPTFSFKDRPAGVAVSRAKETKLKAVGCASTGNLASATAAHAAKAALPCYIFAPSDIENIKIAQALSYGAEYVAVDGTYDDANRVASVIGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR7</accession>
    <name>A0A6A8FJR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000148">
        <property type="protein sequence ID" value="MRN68723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="76" mass="8206" checksum="4974CC09DC88D6FF" modified="2020-06-17" version="1" fragment="single">MGSRFGGYEIPGDVFSSPCLVDDAIIVVGSMNNGIYALEGYNGNVRWKLETGGEVWSSPSYNGNEIFIGSDDGFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJT9</accession>
    <name>A0A6A8FJT9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl6</name>
        <name evidence="5" type="ORF">FIO04_01210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_A">
        <property type="entry name" value="Ribosomal_L6_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_L6_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_L6P_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="99"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="184" mass="20640" checksum="15E40874514E48F6" modified="2020-06-17" version="1">MVISSEEEIKAEIQIPENVKAEILDNVIIVEGRLGKLKKNIMRIPVVVLVQDKKIVIRPYGRRKKDLAITNTVRSIIRNMLTGVEKGFTYKLKIVSAHFPMSVKLRGDKVNIENYFGERSPRTSQIVGKATKVTVVGEDVLVQGPSLEDVSQTAANIELSTKMKGKDQRVFLDGLYIYSKEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU5</accession>
    <name>A0A6A8FJU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000078">
        <property type="protein sequence ID" value="MRN68487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="92" mass="10199" checksum="2ED2A302806D13AC" modified="2020-06-17" version="1">MVVDIVFPGWVPFKDLAIAEDVPDFIKSHEQALSYPFDTLVAGHLTRLGTRQDGVTQIEFVKDLKSSAINATNKYANFTNIAQQVGGFSNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV7</accession>
    <name>A0A6A8FJV7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tpiA</name>
        <name evidence="4" type="ORF">FIO04_01320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="WJXC01000041">
        <property type="protein sequence ID" value="MRN68320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="24220" checksum="68456C179370440E" modified="2020-06-17" version="1">MRLPLIIINFKNYPETYGQNTIELSKVAQKVANDTKVEIVLAPPQASIAAVSQIVPIPILCQHLDDAPEGAATGFFIPEMAKSFGASGSLLNHSEHRLGRQTIRKLIERLRSLQMTSVVCAKTPDEVASIAKFRPDFIAIEPPELIGSGKAVSKHNPSLITRSVEAKARYSSSTKLICGAGIVEKIDVSSAARLGAEGILVASGIVKSHSWSEKIYELASGFNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJX0</accession>
    <name>A0A6A8FJX0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="4">2.4.2.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thi4</name>
        <name evidence="5" type="ORF">FIO03_05470</name>
        <name evidence="6" type="ORF">FIO04_05840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:55704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.59" evidence="4"/>
    <dbReference type="EMBL" id="WJXD01000181">
        <property type="protein sequence ID" value="MRN61485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000350">
        <property type="protein sequence ID" value="MRN69206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00304">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022828">
        <property type="entry name" value="Thi4_prok"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00292">
        <property type="entry name" value="TIGR00292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN61485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="270" mass="29470" checksum="A89A3D0AC988CB93" modified="2020-06-17" version="1">MAKIFADVTETEITRTISMMFNETINEYANCDVIIIGAGPAGLTASRELGRMGARTLVIEQNNYLGGGYWVGGYMMNPVTVRAPAQKVWDELGVPYRRINDGLYATWGPHACSKLVAAACDAGVRFLQLTKFDDLVMKNKRVCGVVVNWMPVSALPRNITCVDPIGLECKIVIDASGHDSVAVKRLMDRGYVKWKGMDPMWVEGSEDAVVNYTDEVFPGLIASGMSVTETHGLPRMGPTFGSMLLSGKRAAEVAMGKLKEMPDSPKLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK09</accession>
    <name>A0A6A8FK09_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfc</name>
        <name evidence="7" type="ORF">FIO04_04125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000197">
        <property type="protein sequence ID" value="MRN68869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rep_fac_C" evidence="6">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="45" mass="4809" checksum="612CB51AE52FB36B" modified="2020-06-17" version="1" fragment="single">KLDHPDEFAALMAEYDYRLAAGAHPEIQLAALLAQLGKLGSKASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK12</accession>
    <name>A0A6A8FK12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class I tRNA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_03895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000180">
        <property type="protein sequence ID" value="MRN68823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="4">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="380" mass="43387" checksum="D78B70EEF956EA5B" modified="2020-06-17" version="1">MRIFNTLSGLKEKATPRDGNLRMLICGPTVYDFSHLGHARILLFYDLVAKYLMSSGKRTTAILNITDIDPKISLRAKEERSSAADISNRFIKELMIDIQSLGINTLCIARTSDYVETAKKLILELLSKKRAYFSNGNIYLDTSSLVSYGKLSQMSREDLVNSRVDIAPGKKNPSDILLWNGIDDFGQKYYDKSLGVGVPWWHMQDSSVAMLIFNGLYDIHGGATELVYPHHESLLAQLQVLTSNQRPVKIWNHVGLVSINGKKMSKSFGNIIRIRDLIRKYNSNIIRLYLFSKHYRQPFMFSQSELDKFYSTDETIASALWKDIGTKIPHRRTRLTKEFTSYIENDVNTPAALELMIETAREGESIADVRYMVRIFGLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK27</accession>
    <name>A0A6A8FK27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000322">
        <property type="protein sequence ID" value="MRN69152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="111" mass="12212" checksum="A9CBA975F1C4B16B" modified="2020-06-17" version="1">MKKDFIISKIEASQDGAPYIYVTFTDANDYKAGGEKQQNPFGPNMMAFTSPEDLMKNLPKMMSNISRMTGGGGVPTDSPTFKMSMKEYEDIGIKVGDKVTIEIKKSENSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK29</accession>
    <name>A0A6A8FK29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000056">
        <property type="protein sequence ID" value="MRN68400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6017" checksum="DB4996694F419EBE" modified="2020-06-17" version="1">MTPRLRNPANAATGGINCTMTAGFEVNLATAEELPLLAIKLHIQNQLILYPWLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK77</accession>
    <name>A0A6A8FK77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO02_02530</name>
        <name evidence="7" type="ORF">FIO04_06000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000026">
        <property type="protein sequence ID" value="MRN39904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000365">
        <property type="protein sequence ID" value="MRN69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="5">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN39904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="376" mass="40032" checksum="741913AEF79E7581" modified="2020-06-17" version="1">MVTVDQVMSSLKKVVDPELHKDIVSMGMVKDLAINDGKVAFTLELTTPACPFNSEIEQDVRNAIASIGETELNLKVTARVMEGRAISMDEILPGVKNIIAVASGKGGVGKTTVSVNLALTLAKTGAKVGLLDADVYGPSVPLMLGLKQTPEVTNNKIQPIISDGVKVISMGFFYEQSQQAGIYRGPIVSGIVKQFLTDVNWGDLDYLIIDLPPGTGDAPLTMAQTIPITGILIVTTPQEVAMNVAVKAIGMFNKLNVPIIGVIENMSHLECPNCQERIHIFGKGGGQRVSEKFNVPFVGEIPLHPQIMEGSDTGKPIILSEPGSIQANAFTNAAKTVAGRISVIAAELKALEETEAEGRPRNDTVSQTEPQNVPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK78</accession>
    <name>A0A6A8FK78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000221">
        <property type="protein sequence ID" value="MRN68929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="194" mass="21620" checksum="B24C031567F7E0F3" modified="2020-06-17" version="1">MLFDLDLYLLRHGDSGKRMAVAAGVNTGDAPLTIVGREEIAIIARSVKALNLRISAIVTSPLKRAVQTAKIIAKVLAIENRISIWNDLVPEGNRSKLYNRLNQYPRDSSVLMIGHEPYLSNMMYDMIFQKNRVNQLGRISLKKAGLAKIRVISLTPNISGELRWLLTPKILKLLEKGSSKSKSSAAKNKKKEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK82</accession>
    <name>A0A6A8FK82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_04310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000209">
        <property type="protein sequence ID" value="MRN68903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040825">
        <property type="entry name" value="FKBP26_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18046">
        <property type="entry name" value="FKBP26_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="255" mass="28544" checksum="334B44306F9B3A84" modified="2020-06-17" version="1">MTLEKGSLILIDYTANIKDTSKIFETTIEEDAKNSDLYDPTRKYGPRLVSVGEGWVLKGLDEALAEANSGDKLDVDVSPDKGFGERIPNKVRMVAQRKLGDKADEVKIGDEVEIDERTGIVRFVGSGRVQVDFNHRLAGRTLTYKVSIIKKLESDNDKVLSLMKRRLPLDDEKIKFILEGSNLTIQFPEETFLTEGLQVIKRAIASDIFKYVGSITNVKFVETYKATNSTESKAESEDDVRSNKEVGAMEVTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK89</accession>
    <name>A0A6A8FK89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybutyryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000415">
        <property type="protein sequence ID" value="MRN69326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="1">
        <location>
            <begin position="279"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="418" mass="46691" checksum="C0A9877558A145B8" modified="2020-06-17" version="1" fragment="single">MPIRNGAEYIQSLRGRSLRVYLFGELVKEPVDHPMIRPSINAVAETYDVANRDSEIASAQSSISGTRVNRFLHIAESTMDLVNQNKMQRKLGQLTATCFQRCVGMDALNSLYSTTFEIDVKYRTVYHKRLIEFIKMLQNENFMIGGAMTDVKGDRSLSPSQQEDPDMFVHVVKRDEKGIYITGAKAHQTGCINSHWIIVMPTMRLRPEDKEYAIVGAIPTDAKGITYIYGRQSCDTRSMEDGDLDAGNAKFSGQEAMIILDNVFIPNELIFMQGEVEFASMLVERFTCYHRRSYVCKTGLGDVLIGAAAAIADYNGVANASHIKDKLVEMTHLNETIFAAGIASSYQAHKTASGNYQNDDMLANVCKHNVTRFPYEISRLAQDIAGGLMVTMPSEKDFRSLETGPLLEKYLKGRKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKA0</accession>
    <name>A0A6A8FKA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_05970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000362">
        <property type="protein sequence ID" value="MRN69232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="220" mass="24502" checksum="59E0613B01F03DA0" modified="2020-06-17" version="1">MTIQEGSYVMLFHTSRKKWLTRVNCEKKVHTHLGVIDVPSIIGLEYGSIVKTSEGKLIHLVEPTIHDFIMKSERRTQIIYPKDLGYIVARTGLKNGSKVLEIGTGSGALTTFLASIVKPSGHIYTFDVNPDFIEIAKRNLEKAAMTAYVTTHLYDPHLGLDIEDVDAAIVDLGDPWTMISQVYRALKPSGAFVAICPTMNQLEKSATELKQNNFIDVLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKI9</accession>
    <name>A0A6A8FKI9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="7" type="ORF">FIO04_04910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000262">
        <property type="protein sequence ID" value="MRN69023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="140" mass="15868" checksum="CE920BA73DD67E97" modified="2020-06-17" version="1">MRAALREKNISPKHSREVALAIKGSSIEKAREFLENVIAKRLAVPYRRYNNEVAHRSNIRDGFFAGRFPQKAAKEFLKLLDNLESNAEYKGMDLDRLRIVSAVVHRGTKLERFTPRAMGRASPKIGMLVHIELVAKEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKJ0</accession>
    <name>A0A6A8FKJ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_03245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000139">
        <property type="protein sequence ID" value="MRN68697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="653" mass="75929" checksum="6A9AD03BD542A24D" modified="2020-06-17" version="1">MTDNQQGTTIADFLKNFPFSDKRDRQAYVLNEICTAFASDYRYILLEAPTGFGKSPVAVAVALTLGSSYICTSTKDLQTQYSRDFPYFKVAKGMNNFPCLVKEDFIKNDTYRCGACVSDNVNECYHTTVEHGPCMSNESFKDSGCKYRTFLKNYKVSNKGTTNENVFIDSDTKNYYQKEYSQWLHLENLKDQRRAWMPCEYFDQLNAALTSSHSIFNYSNFLALLPNKKVLPQRKLLVLDEGHLLETEIVKHRGVFISKKRWKRYIPNLKMIDYGYDDIEKWIDFLIELETQMLDLIGNSSMVESLSISRRVKYNWINDTTSKLRSKNKKRVVGASEIFESDEEIAEKYGENLSKRSSSIGDELAVEAIRDTERLTRAINNILSNTKNWIVSEIRKENYEIVRIELKPLDVSPYCKDIFEKCTKTLIMSATILDSKEFCRNVGLTSNDVKFIQVDSDFPLQNRPIYPMSIAYLNFNNLQLQEVKTKISRAIDNLMTLHRNHKGIIHTTSYEQLNFIKENISQANVRRLLVTDPEIQRDDVIAEHTNSIKPTVLISPSFHMGLDLKDALSRFQIITKVPYPNKSDRWTDAKRKMDEEWYYWQTALKLIQGYGRSVRSKEDWAKTYVLDSAFGYFVRKNRNILPDWFTQAIQGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKK7</accession>
    <name>A0A6A8FKK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF4921 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO02_02645</name>
        <name evidence="11" type="ORF">FIO04_02660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000027">
        <property type="protein sequence ID" value="MRN39926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000103">
        <property type="protein sequence ID" value="MRN68580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="9">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN39926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="342" mass="38455" checksum="94EDEB8E1C5C84D2" modified="2020-06-17" version="1">MGDLRKDYVLDKFVIVPRSSESERIDPPLDGSCPYCPGNESMTEPAQIALVAKDGMLQRLSDSEENIICDWCVRVFQSNTPAVTISSSPSYSDKPLYSEPAYGYHQVLVASPDHDRNLSQISVDQWANVLLVIQDRVRWLYTQKSVTYVAVYIDSGLRAGTSITHPHLNIVTFSTIPPYIEVEAEASHRYMNENGSCPACNIISIESSGPRQILSTDSFLSFSPWAPTYPYEFWIYPKRHTTAFSKITQKEITDLALMMRATLGGMSKALNETPFNLVFHFAPEKKNSRQIHWHIEIYPQIHAWSGLERGFGVYVNNIRPEKAAEVLGSACRRELAGLVGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKK8</accession>
    <name>A0A6A8FKK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF371 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000432">
        <property type="protein sequence ID" value="MRN69352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="139" mass="15543" checksum="738349650905C042" modified="2020-06-17" version="1">MVQDEIIFYGHPNVRSTHKKTIEITKAPTLSLRGDCIIGVNANKACRDLKPTLKRLLQQADLVVKIEIEVSDLSFAIDARSDSRLSLLNHHDIVIRKSDFVCPRTVAITCNKASSDIPSDIVQLLGKPEMQGLLRIRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKM6</accession>
    <name>A0A6A8FKM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Asparagine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_06780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000457">
        <property type="protein sequence ID" value="MRN69388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="5">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="245" mass="28190" checksum="AAACCA00436D18BA" modified="2020-06-17" version="1" fragment="single">MHLRCNDVKYADYIGKEVTVRGWVHRLRKQKENTFMLIRDDRGGVIQCVLATEKALTLTIESCIEVTGKLQQDSRAPEGGYEITATDLKIYGVAKVDYPIGEYQSEDLLLDNRHLAVRTRRMSTIAKIRASILKYARQWFIENNWLEVNAPVIVKDAVEGGSTLFKVRYFDDDAYLSQSAQLYLEAMVFSLGPVWSVSESFRAEKSRTVRHLAEFTHMEAEAPWIILDDLLRIQEKLISYIVHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKR5</accession>
    <name>A0A6A8FKR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1059 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_06215</name>
        <name evidence="2" type="ORF">FIO03_04025</name>
        <name evidence="3" type="ORF">FIO04_06935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000102">
        <property type="protein sequence ID" value="MRN40622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000116">
        <property type="protein sequence ID" value="MRN61209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000480">
        <property type="protein sequence ID" value="MRN69418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="59" mass="6657" checksum="260753284DA1786D" modified="2020-06-17" version="1">MKTLSCREAGFDCDHVVKGENEEEVMRNGGEHAMKVHGMKAEDITPEMKQKIRGLIRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKR9</accession>
    <name>A0A6A8FKR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000527">
        <property type="protein sequence ID" value="MRN69496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="181" mass="20287" checksum="30D945D8ED593A9E" modified="2020-06-17" version="1">MIGTLLISLTLLVIISLFISNQYDPDLFSVYAQGNTNPLGNALSHIFGNITKAFNGLTRLSEYTVTLDGKQIFPNSTLKENIVDKYQPSTYDIRDLKYNLLGFNVTAHDIKIHVNPSRIDSTKTRVDIPLMLARNVTVRNGVINLNYNQVDLGSIYGIYDKTTDKIMVHIPLAVASKYLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKT4</accession>
    <name>A0A6A8FKT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000311">
        <property type="protein sequence ID" value="MRN69129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="12504" checksum="AF8214F114E3396F" modified="2020-06-17" version="1">MPQDNRVEIFKLSEILSKLDNINSYFLTLLSSNSTAIGIIRLKRGEKDTQPPHATDELYYVIEGSGLIEIDGKNHVIEQGTFILVPANIKHRFHDNKNLLIVLYMFFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKT9</accession>
    <name>A0A6A8FKT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000498">
        <property type="protein sequence ID" value="MRN69448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="268" mass="29464" checksum="432CF58ABA8C10F9" modified="2020-06-17" version="1" fragment="single">MSVRKIVIAGVTSGVGKSTIAAAIMYALKRKGFVVQPFKVGPDFIDPSYHTYVTGRQSRNLDIWMMRKSGVLRCFNSCCFDADFGVIEGVMGLFDGVSGKDDFGSTAHVARLLDASIILVIDAAKAARSIAAIAWGFIRFSKSLKIAGIILNNVASQRHATFISDAFAGKIKVPIVGIIERNKKIGMEERHLGLIPTAELEDKKKRAIIRSAKYASEQIDLDKIRDVWNVPREVRNKQSTAQLSTSRLTVAVALDESFNFYYADNLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL51</accession>
    <name>A0A6A8FL51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000375">
        <property type="protein sequence ID" value="MRN69253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="376" mass="43391" checksum="74B9C0CDAFCD6201" modified="2020-06-17" version="1">MSSKDEFIFKKSALMSTKSGKDIIKHIILREKGYKQFHKYNQNNEQEFRDFTKRYLLSLHTQIISDTNPSTTLKKFTEEMGSPELGLDDHKIDEVRARISKPEVLADRVDRLLNSNFVIMTFPVLHALFDGASQYQKETVPMEMRNAIIDGHIIAIDLSEPMDRIIDKDEDLDYLDDYKLMNPYILEIARQKISQGGESILKAFEEGFKDARIGQYIDAKLKTKPESISDENMIGCYKKYRAIMGTAGRNMALNRRPLADIFHLGMAKAGESVGCGNEIQDAIRNGRIKIPSWPLFFSILSGDVKKGFELTIKKGKNYLDEAKLALDMLPEDFQHKPFLEFLFLTVSHYNQYWYNELNRRDLFALLQKNMNGTMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL95</accession>
    <name>A0A6A8FL95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nickel-responsive regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_09095</name>
        <name evidence="3" type="ORF">FIO03_05375</name>
        <name evidence="4" type="ORF">FIO04_03880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000212">
        <property type="protein sequence ID" value="MRN41184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000177">
        <property type="protein sequence ID" value="MRN61467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000179">
        <property type="protein sequence ID" value="MRN68820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NikR_C" evidence="1">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="127" mass="14808" checksum="BC3FC54DC2883BB4" modified="2020-06-17" version="1">MTIVSVSLNRTILDEMDKLEKSHGFSGRSEIVRAGIRNLLSEERKRQDLTGMLHALFLAIHDEDSDDQVTEMRHVYDKLINTHLHSKIDRDRCLEIFLLRGDAREVKEMTKKFQANKNMDNVQLIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLC7</accession>
    <name>A0A6A8FLC7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000411">
        <property type="protein sequence ID" value="MRN69319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="198" mass="22244" checksum="D6F3FEE1C28E3E86" modified="2020-06-17" version="1">MEPLLAKNVGARKSLVKSKPAFLVDAMLGSVARKLRFFGLDTLYIADSPDDEIIGIGIKQNRVILTCDKDMYRRIMKAGAQGILLNGSDDLENIAQTFFSFGTMLGPYIDVGSRCCMCNGLLSEISHAEVKGKIPFNIVNWHTQFFECKKCNKLFWEGSHYLSLRALSKRIDSRIKERLEENNSFANDSISQSIVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLJ6</accession>
    <name>A0A6A8FLJ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Orotidine-5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrF</name>
        <name evidence="6" type="ORF">FIO04_06860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000468">
        <property type="protein sequence ID" value="MRN69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="254" mass="27577" checksum="A9630C25CA9654F1" modified="2020-06-17" version="1">MVDSAAFSHRITEASIIKRSRIILALDLTDKPDLNEFALKTISQLESYICAIKLNFHLILPLSSSELSEVNRLVHSYDLQSIADIKLNDIPSTNKIAISHLSSMGFDAITVNPFIGTAGLRAVVVQAHELKSGILALVYMSHIGAQGGFGINFLGSNNQVTSLYQKFFQDAIACRVDGVIVGANRLEILKEISCKKDRIPIYSPGVGVQGGNIKQAANSGTDYFIIGRSIIGSKDPLKAAKTLQHQLVRVNITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLN0</accession>
    <name>A0A6A8FLN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000230">
        <property type="protein sequence ID" value="MRN68950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="275" mass="31930" checksum="31E314E332106C4B" modified="2020-06-17" version="1">MFRYIHIYREPSTTKLDLSEVSHELANFFPTCEIDLRDPFLQRSCENGQPLDMIAETLASVRISEIKSPYCDQEKRRKKSTIDEIMYEKSLILNASLRPAPFVLYDGFMLQRVYGASMPSEESSTEHAHVIFDPRLTCTFSEEDWRYHARAVICGTPSIISSTGIVEAPAKNKEFYLPEIQFEVMQSNKERLAGRESTSEFVGYNDSRINSIAIGYILQALFFFITDGYPFCHYKNCRLYDAHWQSDLLRTQIKIKKLCKRHRDMLSHYQSLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLN7</accession>
    <name>A0A6A8FLN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">FIO04_07060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000494">
        <property type="protein sequence ID" value="MRN69443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="182" mass="20162" checksum="01483F4F4C22FCA2" modified="2020-06-17" version="1">MLSAIDTLKPGINPPDEINVVVEIPKGSSIKYEINPQSGEISVDRILVPAMFYPCNYGFIPQTKEEGGGADPIDVFILGNYSLLSKSVISCRPVGILSTEDQGGIDPKIIAVPVTKIDPTFSTILDINDIPENVRTRLKHFIEHHKDLVEGKYVKLEGWKGKDAAKIKISEGIKRYNRKFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLS0</accession>
    <name>A0A6A8FLS0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yciH</name>
        <name evidence="7" type="ORF">FIO02_02240</name>
        <name evidence="8" type="ORF">FIO03_06095</name>
        <name evidence="9" type="ORF">FIO04_07145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000022">
        <property type="protein sequence ID" value="MRN39848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000218">
        <property type="protein sequence ID" value="MRN61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000504">
        <property type="protein sequence ID" value="MRN69459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN39848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN69459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="102" mass="11350" checksum="63AFD8CD14EDE3F4" modified="2020-06-17" version="1">MAVICKKCGLPDDLCACGELDKEDTRVVVRLETRRFSKTTTMIEGIDPKLSDIQRIIKELKSRFACGGTAKDGFIMLQGDHRDDVKGYLVKLGFNDAAIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLS3</accession>
    <name>A0A6A8FLS3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_05540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000319">
        <property type="protein sequence ID" value="MRN69147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="178" mass="19600" checksum="A5B6DCAA85DC2F4F" modified="2020-06-17" version="1">MKIGIISDTHDDIENVQKAIEIFNAEGVNYVIHAGDYVFPGVVKEFEKLNAKLIGVLGNNDGENVHLLKNFLDINGDLKGELGEIEIDGLKFGIYHGTAKEVKEQLINSGKYNILICGHTHIREPLHSDGKHENNGKTLVLNPGAAHKKVASISGAFKEGGIIIFDIRTKEYKFIDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLS4</accession>
    <name>A0A6A8FLS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000518">
        <property type="protein sequence ID" value="MRN69483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="295" mass="34827" checksum="46B4E1A22D7F6334" modified="2020-06-17" version="1" fragment="single">HEAGFHEIHVENPLKDLPMLLSIIKEPRWNVYQYYFIEKARSISNVLFTGDGGDELFAGYTFRYKKFLETIKSLNRPCCEERVHTYLLCHERDWVPDQEDMFAGTQIKFAWSSIYQLFKKYFDNNLDPLEQVLLADYHGKLMYDFIPTNEKFFKHFNIDGTAPLLCSQIIDLSMKIPSSLKYDFETNIGKIQLREIIKQSMAGYSSEGTKKMGFGMDLAKFWSRFGKEIVTSNLDKGRIFEDKIINKEWYNKSLTRINENREEATRYMSKMLQLLSLEIWYKLFITSEINASYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLT0</accession>
    <name>A0A6A8FLT0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hflx-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000509">
        <property type="protein sequence ID" value="MRN69469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="153" mass="16980" checksum="88EBD1B331E15937" modified="2020-06-17" version="1">MFTTLSTFTRLVQSKGTKHLISDTVGFISRLPAYMVDAFKSTLQELSYSAVVLLVLDISEPAEEIVKKLNSCIRIMYELGVPMTKVVYILNKADLISVEDVEDKSVRLGLPHSKQRVILISAKTGYKIDTLKDVMTLLVVGDPKPLIGEVSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLU5</accession>
    <name>A0A6A8FLU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000332">
        <property type="protein sequence ID" value="MRN69177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="146" mass="15700" checksum="3314D4CEC8C3E148" modified="2020-06-17" version="1" fragment="single">MKIGIIGSGNIGATLAHLFAKAGHQVEISNSSGQASLNALVKSISSNNVTAATPEGAVRFAQVVLLAIPWRKKHELPPSDLFKGKIVIDAMNPYSENFEVIDLGNSTSSEEVTKQLPGARIVKAFNTMYYESLRTGGRNSEDERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLX7</accession>
    <name>A0A6A8FLX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000350">
        <property type="protein sequence ID" value="MRN69207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="1">
        <location>
            <begin position="46"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="206" mass="22759" checksum="7CEB9DE7811257A7" modified="2020-06-17" version="1" fragment="single">ADASLDAGLPFINATPTKIASNDVFSKKFGEKKIPLVGDDLLSQLGGTALHKGIIDFLVERGALVRKSYQLDVGGNKDTQNTMAERTKMAKRKIKTKSIAIEAPYNFESVAGTTEYTDFLRDSRNSYYWVSSEGFLGSNIVIDMMLQTSDGANAGNVVLDVVRAVYAHHNRKVKNGCELICGYGFKDPPVKYKIRDAYRNFIEAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLZ4</accession>
    <name>A0A6A8FLZ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NosD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000575">
        <property type="protein sequence ID" value="MRN69553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NosD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="166" mass="17528" checksum="57B6D9EBB3506E0C" modified="2020-06-17" version="1" fragment="single">DNGQFGIICSLNCNNITIENNEIYHDGNKNTGAGIMFSRNMVNSIARNNIVHDEVSTAISISESHNNLIFNNTISNSGGGINLKNSTSNKIHDNTIINSTKGIDTSAAGGVAGNMIYNNHFINTPSSSSSSPHSSNSVGSNNQPQGTLKHHNKHSLGGHKAKPGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMD1</accession>
    <name>A0A6A8FMD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03560 family F420-dependent LLM class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000345">
        <property type="protein sequence ID" value="MRN69200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="331" mass="37683" checksum="3D0DF3FCEF4A72D1" modified="2020-06-17" version="1">MQKQHELEFGLTIPQGWRGGDLPLEEENDPAKQYEFSKSISVAADRIGFGSICAYDHFIPFYSDDRDKNIFECFTLLSALAAITERIKIGQIVTCNSYRNPSLVAKMVSTLDIMSNGRVELGIGAGWYEQEYIAYGYHFPSNVSRIKQLDESLSIIKAMWKEERASFEGKYYRIKEAICNPKPIQKPHPIIMIGGSGEKYLLKVVAKHADRYNLFFGTPNEMKTKISVLKEHCKSIGRDYKELQYSIVLPCIIKGTDQEVNQVLVQYKRKDKTLEEYLQYLVGGVAVGTPEKVLQGIKKYIDIGVTHFILHFIGLDETTLRLFDAKVIRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMG1</accession>
    <name>A0A6A8FMG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000361">
        <property type="protein sequence ID" value="MRN69230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="65" mass="7796" checksum="D9FB26F0299D6409" modified="2020-06-17" version="1">MSDYVGRIAATRYRLYLKEEEEKRRHSEWTQYVIAAILWLVKLITNSLEKVNLKSKRVIEKVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMJ3</accession>
    <name>A0A6A8FMJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000490">
        <property type="protein sequence ID" value="MRN69437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="118" mass="13330" checksum="6002BDCA0D461D46" modified="2020-06-17" version="1">MANQIAVKISQLCQMIEDSIHVGKYPLEDQHKRFSNSLQVINRSDSDDLKSSDIKIEVRIQGLYIISNYVPNIEHLPGIIEVDVLDSFKILCRRLSRITDNAGNPKGTVSTEKLPQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FML0</accession>
    <name>A0A6A8FML0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_07135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000503">
        <property type="protein sequence ID" value="MRN69457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="265" mass="28547" checksum="143B109C7C282E12" modified="2020-06-17" version="1" fragment="single">GKMLIVELLVDTKDAMGANVINTMCEAISPKLEVLTGGKVIVRILSNYSTRRLVRCKAIFARDELGGEAIVDRILYAYAFAYSDPYRAVTHNKGIMNGIDAVALATGQDFRAIEAAAHAYAARDGTYRSMTRWYKTNDGDLAGELELPLAVGTVGGVVSVHPMTKLAIKILGVQTAKELAAVLAAVGLAQNFAAMKALVSEGIQAGHMRLHARNIAVLAGARGNLIKLVAQMIADEKNVNIHRAKEIIALMTEKNLNNNTYNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMQ4</accession>
    <name>A0A6A8FMQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000412">
        <property type="protein sequence ID" value="MRN69320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YHS" evidence="1">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="47" mass="5454" checksum="1ECCBCC27BAFE1E7" modified="2020-06-17" version="1">MYKDPVCNMMVDEKKTEYISQAEGRNVYLCSAACKSEFEKNSTKYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FN49</accession>
    <name>A0A6A8FN49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000492">
        <property type="protein sequence ID" value="MRN69440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="181" mass="20289" checksum="7FDEBC52FA6E9B74" modified="2020-06-17" version="1">MKYDVSLQPRIDAVLNHITELERIMCQSISKDGDISRNKDLHQVKNHTIHYSDMSASEYLSTRKLNQVIQVSKILLERLAYQLRNVSNLSDIVIILSPAVGILKNIRSSLIPCIPDSRQELCYICELLEVVLVDAAQLGGYTINFQTANESALHLISEASLNKGGELTKELSELRGALRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FN63</accession>
    <name>A0A6A8FN63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000499">
        <property type="protein sequence ID" value="MRN69450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="102" mass="11117" checksum="3229D64F7A364DDC" modified="2020-06-17" version="1">MESIDDVLPPEKIAFIAYNIGVYESVQKFGGLITSGKITDGTDVSKVAELLSQSTAFYDAIMIAGLINAMLYDTKDKTIERVSPEHVRYVMSQLKATGVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFF6</accession>
    <name>A0A6A8FFF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_04105</name>
        <name evidence="6" type="ORF">FIO03_00565</name>
        <name evidence="7" type="ORF">FIO04_00160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000053">
        <property type="protein sequence ID" value="MRN40209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000009">
        <property type="protein sequence ID" value="MRN60535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000003">
        <property type="protein sequence ID" value="MRN68095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="197"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN40209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN60535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="313" mass="34558" checksum="E95D711EE2787B05" modified="2020-06-17" version="1">MTTKIEDKHLNNKQEQCHSRTVSRIINSLETTEGGGFVVHRSFPTNALLDFDPFLLLDEMGPKDWKPGEAKGAPDHPHRGFETVTYMLEGKFEHKDSRGNSGKLGPGDVQWMTAGAGVVHSEMPEKDFMRRGGKLHAFQLWVNLPQRDKMIKPRYQDVPSAKIPLAQTEDGKVKVKVIAGEALGSSAVINTRTPIFYLHFTLQPGSKLIQPISKEYNTFAYVINGEGLFGPAEKQKIAKTGQMVVFDKDGEGVAFSVAATSTNKSALDMLLIGGVPLNEPVARYGPFVMNTNEEILQAAKDYRNGKMGEITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFQ0</accession>
    <name>A0A6A8FFQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="94" mass="10695" checksum="0AE97315585D3E27" modified="2020-06-17" version="1">MNVEKFECDDKYEAEKLAGFLATQKDNGTFLHGIAAIVQNEVVIILKDKSSHSIIMKDRDTAIRLKSFIEDVLVQKKRISASNFDDHVTEITIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFQ9</accession>
    <name>A0A6A8FFQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000024">
        <property type="protein sequence ID" value="MRN68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="231" mass="26371" checksum="6CE717C2E770722E" modified="2020-06-17" version="1">MSSYSEEVVRRAADIREWLTKQVADKQEEIERLRTMLFLVDMLLKRGSFKTAASLESGTSSSTIKPSDESSTIVGYQQNREAAGNDNNDINAIRRVVVPTAEQQDNTLTSFTEVRQLRRIKDNLVLATATLSPTRVEITPVDGINLNVNTQPFKSFFLNRILEGMKARDIEKVNRGEIQESESLNYQIEEKDGTLIKKIMISNYREKDRLNEIFNTSTWVLTRMMEKDGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFY1</accession>
    <name>A0A6A8FFY1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Elongation factor 2</fullName>
            <shortName evidence="6">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="8" type="ORF">FIO04_00650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000019">
        <property type="protein sequence ID" value="MRN68191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="6">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="733" mass="81053" checksum="6341C1882A70303C" modified="2020-06-17" version="1">MPKFKSTQDILRIIGNKEQIRNFGVIAHVDHGKTTMSDSLLAASGIISPSVAGQALALDSMKLEQNRQMTIRGANVTLFYESEGKEYVINMIDTPGHIDFTGRVTRALRAIDGVVVVSDSVEGIMTQTETVTRQALEERVRPVLYINKIDRLVKELRLDPSAMQKWLSNIIAEFNRLVDIYAEKELKEKWKVSIQANSVAFGSAKDRWGFNFAMAQKKGITFKDVYDAYTSEDPNLIKLLAERAPLHDAVLGMVVQHHPPPHVAQRYRIPKIWGGDLESDIGRSLVSCDDKGPAVMMVTTINVDPQAGRVATGRLFSGTVKDGDEIYLIDAKRPGKIQSVNIYMGNTREVVSILPAGNIPALLGVDYAIAGETISTVKNIPAFESIKYVSEPVVTIAVEPKHPKDLPKLVEALRRITVEDPNLIVKINEETGETLMAGMGVLHLEIATSLLQEAGLDITTSQPLINYRETIRAKAGPIMSKSPNKHNKIFMRVEPLGEDIVELIRTRHIREDMDKKEMAKVLREKGWNADEARSVAAVDVSGNVLLDETKGVQFIQESMDSIKSGFEDVIYSGPIAHETVRGVKFVLHHFVPHEDPAHRGLAQLMPATRRAMLGSMLIADPVLLEPILGIEIKCPQEQIGTVAGILSGKRGKLLNVEQKGLISIIQGEVPASETFDLSEVMRGGTAGKALWNTYFKAWQPVPQSIFRTLVGETRKRKGLNPEPPSPDEFIDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGI5</accession>
    <name>A0A6A8FGI5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_00115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="207" mass="23302" checksum="20CBD4202F51D7D9" modified="2020-06-17" version="1">MICPDRSFYDRSTELVAKELLGNKVVRIISRGQEKPKRLCGIIVETEAYGFNEDAASHAFRGLTLRNAVMFGEPGRAYIYFIYGNHFCLNVSAKPLEIEAGAVLIRALQPVEGIRRMKIFRRNCEELSLTSGPGKLSQALNIQQSLNGEDMTDPKSDIHIEFGVKPPGIITTKRIGTSKGLDKKWRFVSLAMSEKGYTTNRFASRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGJ3</accession>
    <name>A0A6A8FGJ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper-bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000048">
        <property type="protein sequence ID" value="MRN68354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="368"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="446" mass="48598" checksum="3E6EFBCD3233D587" modified="2020-06-17" version="1">MNSSKGSFFFIGLLISSTVFSSILLTVWTKPALGDGLTQEQLTASLGNRKADLLIKMIPPVVTTETLQNGQKPVVEFRLFDSNTNKSFSHVTYYIIIEKDGKRLLADLFHDHNGDLRIQINPSNLSQVSISGQQDPLLGAYIGTSDSPVIASGPIFINGGLYHFIVRIATVDSDSTLLPDNQEPIYDSWLSIGNTVNQQIDLNGKQIPIKVISYYDKLNSFRFDAKNMQMQFNMPFNWNVSRINNTNIFVHEEVYVPNPTPFTANKSFAGTVNGIDVSKDLMLDNSNPNRDVIHVMIPKNDLVGIADQVNKNTQAYNGLMKFTLQPAKGSMSSMPGSNSSMSPAGAAGTNATSVSIVKGASNPSTQKPYNPSPLNVAVGRTVLWINNDNAAHTVTEGNPSGNTPSNGFDSGILSPGQTFKHAFDKPGTVGYFCRLHPFMLGQVMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGK5</accession>
    <name>A0A6A8FGK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000051">
        <property type="protein sequence ID" value="MRN68371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="85" mass="9847" checksum="A8C184C08C7D1392" modified="2020-06-17" version="1">MTSIQLGKNSKYDCTELVYSIVRNNSGKVTGKQLEREIGSRYEVRYAITRLTKEGRIKRIRGFGVDRVEFFYQVVSVVSDTHQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGU0</accession>
    <name>A0A6A8FGU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO02_06515</name>
        <name evidence="8" type="ORF">FIO03_02025</name>
        <name evidence="9" type="ORF">FIO04_03035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000111">
        <property type="protein sequence ID" value="MRN40679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000045">
        <property type="protein sequence ID" value="MRN60822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000127">
        <property type="protein sequence ID" value="MRN68655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JAB_MPN" evidence="6">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN40679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN60822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="138" mass="15392" checksum="7C1612DAB94A5C06" modified="2020-06-17" version="1">MVSSIRLNGDKVESLTSLAKDSLPWESCALLLGETSTENLDEIIVSDVITVKNSDSSPVTFSIDPDDLINAYQVSEARNLQVVGIFHSHPAEPFPSSTDKKYMKINPVVWLIYSTVTNESRAYIFEDKLKEVELRVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGV0</accession>
    <name>A0A6A8FGV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000018">
        <property type="protein sequence ID" value="MRN68186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="332"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="438" mass="45959" checksum="7EE884AD65111ABB" modified="2020-06-17" version="1">MTKARELSLIAVIVILVAVIAIQSITNSRILFLIGQQPQQLLLPFLSTIINGAKQLQKQITGQNNNNGDCAGAAVTATSFTNPSSSHNSSQILSLTGIFKQVENSVVQITSTISNPNIQIIINGNPIEGQSTRLGSGFIYDKQGYVITNNHVVGNAKTVDVTFVDGNTYAAKVIGTDPFSDIAIIQITDNFSTENVLPLVIANSSSLQVGQQVIAIGNPFGLSDTMTTGIVSQMGRLLPDPNTGFSIPNGIQTDAAINPGNSGGPLLNMHGQVLGMNTAISSSTGEFSGIGFAIPSNTIIREVPALIEHGCYSHAWLGISGGSVTPVLAQTVGLSRNYKGVVVGSIQAGSPADKAGLQGVTQDEFSNTQHVGDIITGIDGHSLRSIDDLISYIDVHKSVGDNVVLTVNRHDQIMNMNVVLQTRPPSLENATSQGSILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGX8</accession>
    <name>A0A6A8FGX8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000083">
        <property type="protein sequence ID" value="MRN68511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="250" mass="28367" checksum="82840D5FA8AC4F88" modified="2020-06-17" version="1">MQIVQLSDIHIGSLFNQNVFDTLVEEIENLKPDAIIITGDLTDDGLLFQFERAQFEINKLACPNKIVLAGNHDYRHTGYLVFKKFFPSKQIYELEDEVVIMALGTARPDRDEGEVGYRQNKWMIETLAKCENKTKIIAMHHHLIGIPDTGTDKIIILDAGDTLMACLQSKVDLVLCGHKHRPWVWNLGSLEIAYAGTASSTRFRGFFENAYNILDVRNGKSQIDIKIVGGKRMPLLNLVNKYKPFLETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH02</accession>
    <name>A0A6A8FH02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF373 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="390" mass="42006" checksum="B4B64EC38C8C0FC1" modified="2020-06-17" version="1">MPSVDNYAKKNGAGLSRVAVTAASTHSRILVLCVDRDDDIGSKGGMETPVVGRDPCINAGVRLAIEDPEDPDANAIFAAIKTYEELISKGYSSQVALVAGKFNRGIEADEKIGLEIQNVLGEYRADAAVIVSDGEDDETVVPVIQTMVPVISIQRIIIKHSRSVEYSYAVLGRYVKMLAYDPRYSKFFLGVPGALLVATSLASFFGLTKEALALVFSILGVAFIIRAFDIDKALSSLGRPTPTGFIRIFSAFAGILIIVVSIVNGLSSIPNEAIVPNMGALHVISNRIIVGSFVHGTITLLWIGIATILAGSLLSNWFKGSILTMSDILRLVVLALLYIPILQFTSVLTERTNPFSLISSLLIGLAITLVAATFLFQYFRNRKGGEDLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH03</accession>
    <name>A0A6A8FH03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS1634 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000149">
        <property type="protein sequence ID" value="MRN68725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="228"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="626" mass="72798" checksum="87351ED38A9964C2" modified="2020-06-17" version="1">MFLKVIFKTIKTTGERRKHYRLCESYRSDNTVRHLTILHLGSLEELPEIDQKKALATRIDELVKQSHTGKQNLFQPPDQLIELLAQKFFAAIKEKQRLDITVGKDYHRVDTDTVKNKNIKEIGSEWLCMQALEQLDITSFLTLKGWPPEHIQLALTHIVSRATYPASELRTSQWIKENSAVCELTGYPTEKITKDKLYDISKCLYKVKEDLEKHLSKCTNELFDLTDKIILYDLTNTYFEGSMRSSKKAKFGKSKEKRSDARLIVLAVVVNTEGFLKYSQIFEGNIADSKTLKQIICELSSRTSSTERHPIVVLDAGIATEDNLKLLKEHNFDYMCVSRSNMKKYSVDADSKPIEILDKKKQALTLQKITVEGNTDTWLRVHSQAKALKESGMNSRFSQRFEQGLSQIKESLDKKSGIKKQEKVWERIGRLKAKYQSIHKYYDIDTQANNKGAVTNIIWKQKPLEKKEGYYLLRTTLDQKDEQVQWTIYNTIREIEATFRTLKTDLDLRPVYHKTDEASMAHLHLGLLAYWVVNTIRHQLKQKNIRNEWRDIVRIMNTQKIVTTTMENDHNQQIIIRQCSEPTDQVNKIYTALKYKPQPFSRKKSVVPLPEMKKNETLEKPDLFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH16</accession>
    <name>A0A6A8FH16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_02460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000092">
        <property type="protein sequence ID" value="MRN68541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="153" mass="16704" checksum="B437F8962349C45D" modified="2020-06-17" version="1">MVDDRMNVMRIVCLSFASLALLFTVMLIGTYVDASHQGLSCPDWPLCPNGFNFPPKKYLFEEIHRIVAAITAGVIFATAGYAAKKSGIMRKTAITAGIIVAVQIVLGMFVVNTKLNALLVATHLSTGVFLFALALITFVSSYRLINIPNHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH49</accession>
    <name>A0A6A8FH49_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="16">BCAT</shortName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ilvE</name>
        <name evidence="17" type="ORF">FIO04_02665</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 16">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 16">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="WJXC01000104">
        <property type="protein sequence ID" value="MRN68581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 16 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16 17" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MRN68581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="299" mass="33652" checksum="2EB3CC8A5DD1D444" modified="2020-06-17" version="1" fragment="single">WMDGSLVPWDDAKIHVLTHGLHYGTAVFEGIRCYKTHHGLAAFRLPDHIRRLMHSAKMYFMDLGYSEKQLQDAVIDTINANKPEEYYVRPIAYYGYGKMGVNPLPNKVSIAIAVWKWDEYIRQSEPQKGARLMVSSWMRIDGKSMPMNAKATANYANSALARMEALKMGFDEALMLNTAGKVIEASAENIFMVRDNVLITPPVNSGALNGITRDSVLAILRHYGSLYEIRDISRDEMYIADEVFLTGTAAGIRAVGDIDNRIIGNGDIGQLTMEIKSKFEAVTQGRDDNFNKKWLTYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH57</accession>
    <name>A0A6A8FH57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroorotate dehydrogenase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000035">
        <property type="protein sequence ID" value="MRN68286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="179" mass="19550" checksum="5904B9D2D0F7E3CD" modified="2020-06-17" version="1" fragment="single">MPININIIRNVFIERVLNETPSIKTILFKDRFASNAEPGQFLMVWIPGVEELPMSVMVADEEDSAAITIRRKGIGSTALFNKRIGEMLGIRGPYGNKFKIAPNARTVLLVGGGTGLVPLIRLAAKLNEMRICCTLIIGASSKREVFFENTADAVLSDTKHKIIVSTENGDYGIKGNATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH78</accession>
    <name>A0A6A8FH78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chlorite dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_03805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000175">
        <property type="protein sequence ID" value="MRN68805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="242" mass="28072" checksum="A6345E8AC1BED426" modified="2020-06-17" version="1">MASRGEIQDGARSPSPSSSSVTPIYLNFSFFKVDAKWRWLNDIAKGEAAKEFSILIEVANTKMRVRTYSTMGLRPDTDFMLWMISDSVEKMQILTSKVYSTLLGKYIEPSHVYLSCLRQSVYSTNKVMPGFMTDEKPMKYVIVYPFIKAREWYLLPFEERKKMMEEHITVGRKFPQVRLNTSYSFGINDQDFMLAFETNDLIIFQDLIVQLRETSVSKYVIKDTPMIVCVYKGMEDIVRSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHE3</accession>
    <name>A0A6A8FHE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000052">
        <property type="protein sequence ID" value="MRN68376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="209" mass="22920" checksum="1D0F301B0F6EBB69" modified="2020-06-17" version="1">MIAALMCGGRGTRMGIAPETEKPLLKLKGSTMIDRVLHALVGSGQFEKIVAIPSINTPKTNTFIRNHYYSSLEPIEVVETGGISYSTDLSVAVCKFKPARVFVVSSDLPLLNSKIVQNIVVRCLPSNPCVSILLEKLFVESIGIKPSIVTVIRRKGYCHSGITILDSSKVNREFSLAEHYIVMNEKALAVNVNTTRELEIAEGMLEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHF8</accession>
    <name>A0A6A8FHF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000023">
        <property type="protein sequence ID" value="MRN68218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="201" mass="23273" checksum="D5B6795A953E17EC" modified="2020-06-17" version="1" fragment="single">MKEKDLKYLFIKSVHAGHIDGNDFFSTERSGIEIKIKDEGYFRNFDLVVAIIKKRNDSDIQFDSTDSYDNYVNIIRRTGQLIQFANKEKCRIDWISFFPVELKSDDDVLDDRLPNQILNAILTFGRAILVLDKKHSERAKLRGILNLIPATIIGYTGREDYFEVLSVFRRFITTGMIGLNKKRLVKLLRANQIDSNSGVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHP5</accession>
    <name>A0A6A8FHP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_02085</name>
        <name evidence="3" type="ORF">FIO03_01375</name>
        <name evidence="4" type="ORF">FIO04_01255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000019">
        <property type="protein sequence ID" value="MRN39820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000026">
        <property type="protein sequence ID" value="MRN60693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000039">
        <property type="protein sequence ID" value="MRN68308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="122" mass="14083" checksum="4B7BE00F1AFE3F28" modified="2020-06-17" version="1">MKRILIVEDESDIIFTLKIILEQNGFVVSSFTDPLLALSSFKPHLHDILLVDIKLPSMSGLELYKEIRKIDEKVKICFLTASEINYEELRKAVFPSVEDAKCFIRKPVENEALLMQLNKMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHR6</accession>
    <name>A0A6A8FHR6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_00180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000003">
        <property type="protein sequence ID" value="MRN68099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="51" mass="5586" checksum="1BC399BC38E0A3BE" modified="2020-06-17" version="1">MRAVIIKNHGVVAVGSNIHQARAVVEALEEWAKILTISKIFGGPKYVLDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHS8</accession>
    <name>A0A6A8FHS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000048">
        <property type="protein sequence ID" value="MRN68352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="152" mass="18207" checksum="1C3629B832975191" modified="2020-06-17" version="1">MNCHIDRVWEFFTDIKHLEIITPKEIELKITNVTNQKLTQGSEIWVEGKITMMLSKRSKWHSMITSSSASPQQRQYVDEMLTGPFEKWRHLHKFYDVNNNNNQKQTQVVDKIDFELRYGRIGRLFDDYAYKSLQKLFCHRKIATIRVLENNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHW3</accession>
    <name>A0A6A8FHW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000011">
        <property type="protein sequence ID" value="MRN68149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="62" mass="7477" checksum="B04864CAF58230D1" modified="2020-06-17" version="1">MKRKDNRTSEVKQYYDFFHKNFKSVSRIRVGIEEISSDTDEKEPKQVCDEILGYFKKRQSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHW8</accession>
    <name>A0A6A8FHW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000273">
        <property type="protein sequence ID" value="MRN69045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="190" mass="20762" checksum="F2065CC29E09C07A" modified="2020-06-17" version="1">MMIGSINKNVTFTFLLVAALATMIILPMQYAKAATYTDPLTGKTIQYPDMWTPVQSQEAQFLQPMTHGNLVFFDNSNGIPLATYGSVPASDPNSISNSMMSVTGTQLLNLKDITLASGKPALQFEFYYQSPTIHPNGDLGDTFTLTGNQIHTGGIAIIEEGILYAVDFFPDSGKNNPYYMKQILDMANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHY2</accession>
    <name>A0A6A8FHY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_01715</name>
        <name evidence="2" type="ORF">FIO03_07175</name>
        <name evidence="3" type="ORF">FIO04_00095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000015">
        <property type="protein sequence ID" value="MRN39751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000284">
        <property type="protein sequence ID" value="MRN61811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="102" mass="11513" checksum="ED162A42F0242820" modified="2020-06-17" version="1">MTEYDSGAYSVHFAHFAAKLEAHLIRFGVTCADADSIIEESSIIYFEKLGSAKKKLLKFVRKEDPAKVFVDSAYRAIERHIPEANNSFGSHIELSKCIHQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHY7</accession>
    <name>A0A6A8FHY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_05265</name>
        <name evidence="4" type="ORF">FIO03_07845</name>
        <name evidence="5" type="ORF">FIO04_04035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000078">
        <property type="protein sequence ID" value="MRN40435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000330">
        <property type="protein sequence ID" value="MRN61934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000189">
        <property type="protein sequence ID" value="MRN68851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN40435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN61934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="150" mass="17446" checksum="AC3A4C976DA851D7" modified="2020-06-17" version="1">MVYAVTVERSIGAVIKFQSPSDEDDTYRAESAEFLLLRNRRGFWGFPQGHKERGETEIETLKREVAEETGIEDIDIQSYIGRIRYSYFRADGMKSNKEVTFYFASSPSRLIKISKEHEGFKWVTYSDALSLLNHRQLISILIRGHRKGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHY8</accession>
    <name>A0A6A8FHY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multicopper oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_04050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000191">
        <property type="protein sequence ID" value="MRN68854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="92"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="241"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="393"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="509" mass="57283" checksum="7544F2B147B8C762" modified="2020-06-17" version="1">MNKKDNKDYSKQQRMKKESYLSLGSFVSLAIFAGLLLSNIGTTSFLVQKQAFGLENQPQSTPFPGMNFAKPIDVWSKNGVLKTTLVADYQAGTIDGKPFTAMLYNGSLPGPTFHVFPGDRIELNLINNLNEPTNLHWHGFHVSPANNSDNIFLEVGPGKTQHYSVYIPKDHPLGTDWYHPHLHGVTYSQVNNGLTGLFIVEGLQKLLPKPLQNITTHTFEMKDFPWDPLFSTTHNMSNTLTGHEKLTVNGEVNPTVNIKSGETQLWRFINMNSESYITVGLSGYKFHIIAEDGYPVWKVRENGTLFLPFGKRFDVLVTGQGNGSIPLRVVNDTYNDHPFGTIVATVHVQGNQNVKPVSLPTTLPPFANSSSISKWKDLSNATIAAHRVLYWKSDDRDWVYTINNQTFDPNRVDEKVKLGTVEEWKLINLDPVQSGNFHPFHLHTNDVQVMSVNGKPYNADGRQDTVMIPTHSTVVIRIPAYDFVGKTVYHCHLLFHEDYGMMGTVEWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI09</accession>
    <name>A0A6A8FI09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_05225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000290">
        <property type="protein sequence ID" value="MRN69085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="532" mass="56576" checksum="2BDFDAE515C6513F" modified="2020-06-17" version="1" fragment="single">MARRRVTSYLYNKALTIRLIVTSIPIAYPIVVMGFVAATAVIGILAGKLVKKSSKRYIVAGKSLPLFFIGTMLVSEAVDGNASLGNVSATFTGGFWAGGTLDLGLAICLVLTGAFFGKIFNRMNMITLADFYFRRYGNVTEIMSGTLMSISFIVLVAGNLAASGYILSVVLGIPLIYAMLISTAIVLLYTYFGGLFSCAYTDIFHIYLAVAGFWLGFIYFIGPWSPIPGGLQTIIANVPGNFMDMSGLLAVTNPASGALPNWATIISLGIGDIVALDFMERVFAADGGRTAQKGCYMAAGLTLLIMIPVTMIGIIGHTLEPKISDPYTLFPIVAITHSPTIIGIMMLVSVVSCGMSTANGGTLAIASVLSRNMLQRNIIKHILKRPGLSDRQLLIATRLFVIPMFFTAFALGAIIPRPGGYLVLAFDIVLAGCLVPLVFGTFWKKSTAAGAIASIAVGSALRMILYFLISTAPSSSPYAAYLGLDTMIPPIVSLAVFVGVSLKTQKLTPPRHDVIYLIPSDDDTVTGADLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI22</accession>
    <name>A0A6A8FI22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhoU family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000294">
        <property type="protein sequence ID" value="MRN69095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="139"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="231" mass="26271" checksum="E545741F43E9E5F0" modified="2020-06-17" version="1" fragment="single">VLMGTEIIADSATSITLQVLINLLELSVDAAFKRMLLIAKSMHRDAILSLRENNIELAKEILKSDDEVDRFSFYIVRQLNIAIKNEHLLKEIGLDDSRNCLGYRLIAKSTERIADHAGLIAKDIIEMERPLNKDIIEKIAEMSNFALEVLDEACLSIFKRDYDSADLAIEKSRGIDDLEKGIIRVASKLRDINEIYRIKIITENIRRVAEYASDIAEIVLNMTVQQKLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI41</accession>
    <name>A0A6A8FI41_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FIO04_05375</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000304">
        <property type="protein sequence ID" value="MRN69115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="12">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MRN69115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="400" mass="45617" checksum="B9B2BE44DC1F2D25" modified="2020-06-17" version="1" fragment="single">MKVYNTLTRRLDDLNCDGAASTRIYLCGVTVYDNSHVGHARTIVVFDILRRYLLSKNCPVEFIQNFTDVDDKIINRAIQEGVTVEEVASRYIQNYFKDFNSLNVLVADRYPRATEHIREMIQLISALMKKGYAYLSPNGIYFRVRSFSGYGKLSKKSIEDLDVGARIEIDQSKEDPLDFALWKFYSDPPVWDSPWGMGRPGWHIECSAMALKYFESPFEIHGGGYDLVFPHHENEIAQSESFSGKQFAKIWIHSGMVTVNSEKMSKSLGNIVTIQDALSRWGPNSIRIYSVSVHYSKPLDYSEKLLNESKHKWRQIETCACELRFAIGNKGYLTEVEQLSDQTMKAFESAMEDNLNTSLAFTAFLKLVTELNRYAAEEKLTADMSKIAGVVFNNIMNVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI43</accession>
    <name>A0A6A8FI43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_06450</name>
        <name evidence="3" type="ORF">FIO03_00360</name>
        <name evidence="4" type="ORF">FIO04_02030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000108">
        <property type="protein sequence ID" value="MRN40666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000005">
        <property type="protein sequence ID" value="MRN60496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000070">
        <property type="protein sequence ID" value="MRN68458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="84" mass="9186" checksum="4F69279D5F5FFEFD" modified="2020-06-17" version="1">MPTAYILVNCTLGSEEKIIAEISKLPDIKEVRGTYGVHDVFVKVKSDNTEAMNHTITNKIRKIPGITSTVTLVVIDEQGGKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI65</accession>
    <name>A0A6A8FI65_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">aspS</name>
        <name evidence="8" type="ORF">FIO04_03040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000127">
        <property type="protein sequence ID" value="MRN68656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="138"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="405"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="434" mass="49392" checksum="C2F79AFDDFF0FFAE" modified="2020-06-17" version="1">MSVFDDIHRTHYTDQVQESLIGQLVSIAGWIEDIRDIGKVAFLTIRDIRGAAQVVLSANTLSAVKDKPRQSAVIVSGVVQHSKSKDFPLEIKAEKVNIVTEATHPLPIDPTGRVESAIDKRLDSRALDLRNPKTSSIFVLRSAVLDNIRTTLRSKAFVEVNTPKIIGSASEGGANLFGFEYFKKQAYLAQSPQLYKEQLILALDRVFEIAAYFRAENSHTVRHLTEFLSVDIEAAFINYEDAMDLAEEVIRNTFNINKIIDRTDSDVLHDQLKIPTPRFPIDRLTYEQCIEELGKEGEKLEFGEDLSDASLRKLGEIHKGFYFITDWPLNLKPFYIHEKLDNLKLSQSFDLQYGYLELISGGQRQHDPVKLRKGLIDQGLNPMNFDRHLRVFGWGMPPHSGWGLGFDRLMMVLTHSDNIRETVLYPRDTERLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI80</accession>
    <name>A0A6A8FI80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Toprim domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_05015</name>
        <name evidence="3" type="ORF">FIO04_02240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000071">
        <property type="protein sequence ID" value="MRN40387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000081">
        <property type="protein sequence ID" value="MRN68498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="145" mass="16491" checksum="52769455447A146B" modified="2020-06-17" version="1">MRYKVIDDNIVYRLRGFINMLNEESENGSVIVVEGKRDARALASVGFNGNLTVFSRFKGVADFVDNHCTFGKKIILLLDMDRTGKHLTSKLLKRLQLNGNNVSLFYKSALARICNGKIRHVEDLVAYGPYFSGITGNRKDLYFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI93</accession>
    <name>A0A6A8FI93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
            <ecNumber evidence="2">2.5.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folP</name>
        <name evidence="2" type="ORF">FIO04_00610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000017">
        <property type="protein sequence ID" value="MRN68183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="284" mass="30876" checksum="77B0D0B61952FEAE" modified="2020-06-17" version="1">MGKLRIGGEVPARIMGVINVSPESFYKNSVKTNVNEIANVVTEMQETGADMIDIGAMSTAPYLETIISVQQEIKRMRNAIDVIKSNCSLPISADTPRSEVAKEAIKGGADAINDISGLKYDKKMADIVARSGLPIIMGAYGGSGGRSALASGSVFGTIKVLTESISIAKSASIAADNIIIDPAIGFFRPKGKNPFFTKMTDLPWYIRDIEVISNLKKLKRFSKPICICVSRKSFIGNIFNLEPEERLIPSAATELICILNSANLIRTHDVKETWHTLMTSELLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI94</accession>
    <name>A0A6A8FI94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongation factor Tu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000244">
        <property type="protein sequence ID" value="MRN68984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_EFTU_D2" evidence="1">
        <location>
            <begin position="90"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="247" mass="27052" checksum="5904FD74EF7E129F" modified="2020-06-17" version="1" fragment="single">ILNVTKIDKYLGEQVLALDAVNFSEGFILHSYEVDEMKLKTLIKNTAISDFQFLDNIDQLKQQMSRLEPKSLEGQCIIPIDHAFNVKGVGTVVLGVIKQGAVKTFDHLKILPSGKDILVRSIQMHDDPVTECKSPARVGLAVKGVDADDISRGDVLCSPGSLNLKVATDAIPAGFIKSPYYKGDLTDNQTYVISVGIQIKPVKIKYNNTGTIQISSEKSFVFFSGQKYALLKPDNVGTRIIAKGIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI96</accession>
    <name>A0A6A8FI96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000082">
        <property type="protein sequence ID" value="MRN68502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="145" mass="14578" checksum="41C3E094399FB91F" modified="2020-06-17" version="1">MYTTTRRTSTILAIVVVAATALTLLSSTTFTSSAFAAKTGSSGTKNLKNLFACQSSAANGHFGQLTETAVMDCYSQAFSSSLGVSGNNNNPASDTGSASSTNSTNSGSTSPTHTVSSSSHTHHHHHTPTSPSSSTGTSTISSAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIB8</accession>
    <name>A0A6A8FIB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_05685</name>
        <name evidence="2" type="ORF">FIO04_02360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000194">
        <property type="protein sequence ID" value="MRN61527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000086">
        <property type="protein sequence ID" value="MRN68522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="83" mass="9412" checksum="46FDD2B854C02945" modified="2020-06-17" version="1">MNTISFRFDRYKGADELNDNNSNNFSKAVERRSCWSVLSIDGLGIEAKIIHKGRGKFKILEDNCKGKYIGKIVDASDVIRCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FID1</accession>
    <name>A0A6A8FID1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000022">
        <property type="protein sequence ID" value="MRN68213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="546" mass="60583" checksum="9832876CD3B2F6A3" modified="2020-06-17" version="1">MGFRMRYLDLKRKICSVRMLAIQGIAEAGSGHPGASFSAAELMGVLYFRKMNHSPTKPDWSERDYFINSKGHSAPGFFATLAIAGYFPPTEMKTLRKLGSRLQGHPVRYTQKETHQSVPGTEFSGGSEGIGLSVSIGIALANRLDGKKNRVYTLIGDGESNEGQIWEAAMAAAKFKLHNLVAILDRNRIQQDGFTEDIMPLDPTRDKWSAFNWNVIEIGGHNVEQIIDALNKASEAKDSPTIIIANTVKGNGIKHMTNNPQWHGKAPPREHTPLLLEELRSECLIAPSIIAGQQENYEEKIRSAERGGADIIHLDIMDGRFVPNTTFYSDTIKQLRHITTLPFDAHLMIENPLAHIQDYIDARCDIVSVHAETCSESEFAQITHRLLSNGISPGIALNPSTDVPNWLFPHLQDVDVVLIMSVNPGFAGQKFIPEVLSKIRLINQKLREHGFLGYIEADGGIDATMLQAVYEAGARIFVAGNAVYGSGDIHGAIIQLRYKVNVALERKLLEQANTIGIRRDWLKTRKHILIPLANELGIEEELHALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FID5</accession>
    <name>A0A6A8FID5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_01260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000039">
        <property type="protein sequence ID" value="MRN68309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="344" mass="37337" checksum="0D886B5FF2A9677B" modified="2020-06-17" version="1">MKAVFVRGKNKVAVDDISVPNLGDRDVLVKMRACGLCGSDLEKVYGDYGMSSSRLGHEPTGDIINVGKSVKGFSIGDRVFVHHHVSCHACHYCWHGDFTMCNMYQKSNIEPCGLSEQILVPEANVIRGGLVKLPENVTFDEASLIEPLACCIRGLAKCRLQKGDDIAILGAGPAGLMHAILAKLTGAGKIVAFDLNQFRLDFAKEHFGIDTYNVAREKDIIKKMQDITDCRGADTTIVATGNSKAILQSFELTRKGGNVLLFGVPTEGTRVLCNISKVYSSELSIIPSYASSEIEINQAIRLISSKRIEIGSLITHRFDIANAGEGIECAHRAEDAIKVIITAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE3</accession>
    <name>A0A6A8FIE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000094">
        <property type="protein sequence ID" value="MRN68552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="64"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="239" mass="26438" checksum="6B3B21B4C4DFC7FF" modified="2020-06-17" version="1">MKNNRINALMVRVTIVIFFAVLATSLSLLLSSLQPHHNPFYAFAQIQKNVALSLSNLIKHGASYQGSTSAPVTLIDFSDLQCHLCDRFVTATEPQINSTYVQPGKVAFIFLHLPNRGFDSFPAASAAQCTSDQGKFWQYHNLLYNNQGPIDSGWANRDNLKKFASQIPGLDMQKFNSCFDSQKQKPVVESNVALAHSLGFTQTPSFIIVKSDGSNPQKVEGPQPFPEFKFLIDKELGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE7</accession>
    <name>A0A6A8FIE7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000025">
        <property type="protein sequence ID" value="MRN68233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="355" mass="39704" checksum="A13416CD5E084B0F" modified="2020-06-17" version="1">MVIELRGCFHGGIYSVDPSLVKIDFSSNVNPLGVSKIVLSSIQKDLRSLSSSYPDPECRDLKKSLSDYLKIHCECINVGNGATEIIHNFARMFAREKVIIPSPSFCEYELASRRMGASFILVPLKNFNLDADQIIEKAKGSDAIFLCNPNNPTGLLYRKSLKTIIERLDSSTKILVDECFIELVNGSNRHTMIRNIDEFDNLIILRSLTKSFGLAGLRLGYSVSNPRLAKKLASGQISWNVNGIAQRAGIVALRDSQHLTRARAIVKKERDFMYSNIRKKTQCFSPFKSDANYFLIRLTNHNSSTEVRDSLLTRSGVLVRDCSTFSGMGSKYIRVAIKNHGENLILLNALESIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIG3</accession>
    <name>A0A6A8FIG3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_00970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000029">
        <property type="protein sequence ID" value="MRN68253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="262" mass="28073" checksum="9D9DF90DE455065A" modified="2020-06-17" version="1">MTLSLAKSNDTLAEAQASQDNGIIIKTHINAYRFENLYSNIQQALIHFINAFTNILQALFSVRNTVGYDTLKSTIALFVVIDPIGTIPLFIALTEKMGREERKAVSKTAIITSGVLLVVFAVAGTQILTIFGITIFSFMIAGGILLFIVAIELLTHGIWRFGASGGSLSAGESGVVPLAFPLLAGPGAITSVIISFQTAGLIVTILSIAIVIGITYGILQSINPIYRLLGRRGAMIITRVFAVFIAAIAIQYIIEGVKRLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FII1</accession>
    <name>A0A6A8FII1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_04235</name>
        <name evidence="3" type="ORF">FIO03_02740</name>
        <name evidence="4" type="ORF">FIO04_03610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000056">
        <property type="protein sequence ID" value="MRN40235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000067">
        <property type="protein sequence ID" value="MRN60961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000163">
        <property type="protein sequence ID" value="MRN68766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="167" mass="18217" checksum="EF3677EFE1CCAD5F" modified="2020-06-17" version="1">MISYCRNNCNKLSNLKAKISKVLAAIDGSELSIDAADYAVLIAKQNNAQLIALHVIRSEEAYQYASNLTEVVTPTSVDSMVQTVKQDSQKWFDIIEQKSNANNVQVKTDIMVSPNSTAGTIVDYAEREGIDLIVMGTRGRSGFKKLLLGSTASDVTAYAHCPVMIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FII3</accession>
    <name>A0A6A8FII3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03830</name>
        <name evidence="2" type="ORF">FIO04_05055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000108">
        <property type="protein sequence ID" value="MRN61170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000275">
        <property type="protein sequence ID" value="MRN69051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="189" mass="22707" checksum="219CA10A361F65A5" modified="2020-06-17" version="1">MRIILPENISERIGEFLIGKQDFPFVEGYELMCVLFLFGRPSKVDDSEKWEVMDLASETVNKFYLEIEGYKNSPKTRMNTEFIRSGYFERELQIRTEEKKAVHKERILNDPTMLSYCFMQHVSYYNQEYFFQIYGPLKGQELLKDLRNYLEGRMIMLGFNRKNEKHLPFQHPIIPLYVWLKDHLIGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIL3</accession>
    <name>A0A6A8FIL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_00595</name>
        <name evidence="3" type="ORF">FIO03_00465</name>
        <name evidence="4" type="ORF">FIO04_00060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000004">
        <property type="protein sequence ID" value="MRN39532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000007">
        <property type="protein sequence ID" value="MRN60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="278" mass="31137" checksum="CE2520DA67CEBECA" modified="2020-06-17" version="1">MGKSHRVAIVQMKSSSNKEENLKISVDFIKEAAKRKARLICFPEFQMAFSPARQSSKQLAEIAESAKNGKFILKLCSTARSYNINVVATIYEKSDRLSENRVYDTAVLINSKGKIISHYRKVHLYDALGSKESLKLIAGDSIEAPNHTSAGTIGLMICYDIRFPEMSRILAVQGAEILAAPSAWFQGVMKEEHWETFLKARSIENGLYMAAPDQVGNIFSGRSMVIDPFGTVVLDMGNREGMEVVEIDISRVQNVRKSLPLLKNRRTDVYRNHISAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM1</accession>
    <name>A0A6A8FIM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_01725</name>
        <name evidence="2" type="ORF">FIO04_01230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000035">
        <property type="protein sequence ID" value="MRN60762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000038">
        <property type="protein sequence ID" value="MRN68303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN60762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="103" mass="12065" checksum="EEB9BEBA131C4F69" modified="2020-06-17" version="1">MTGCTIHADFFDDRCSECKKEYNEMKGIPDKPISDKNGSSSIHNNPMVHKKYKEFTEVRAKKLYEELIIQYLKSSNEAEAAEKARSIIRKQCKIRGMPYWSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS9</accession>
    <name>A0A6A8FIS9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type I dehydroquinase</fullName>
            <shortName evidence="1">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">aroD</name>
        <name evidence="2" type="ORF">FIO04_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000331">
        <property type="protein sequence ID" value="MRN69174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="3-dehydroquinate binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="235" mass="26691" checksum="6D7D780D3DD91476" modified="2020-06-17" version="1">MPKICASIASPAPEDLKKQIKRAFSYGADFVEIRFDFLMLADMQEALEIVKGIRKRAVFTLRSAQQKGKFTGTNEDRIFWLKQLSLSQPMLLDVELETLLDNDELVDFVAEQETRILVSWHDFEKTPTNDKLVDVLGQMRIYSNYVKIATAAQNVHDCIRLLDLYDDTTELNLISFAMGELGILSRILCTIYGNAPFTYAALEDAVAPGQLTVQQMRKLYDRIDLCSGKINARLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIT9</accession>
    <name>A0A6A8FIT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SidA/IucD/PvdA family monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_03270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000141">
        <property type="protein sequence ID" value="MRN68702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="8">
        <location>
            <begin position="351"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="469" mass="51396" checksum="0E2701BA08E289EC" modified="2020-06-17" version="1">MQKFDLIVIGAGSGLEVANAAYQHGLRVAVVEKDRMGGTCLNNGCIPSKLLIHSADIAETIKRADLFGIKVDGYAIEFEKIVQRVNSITDSDSDGIRNAFEGVDNPKLFPKECKFIGPKTITIVGDDSQDIITAEKILIASGARPRIPNIKGLEGTGYLTSEEALRLKKQPHTLTIIGGGYIACELAHFFGALGTKINIIQRKNVLIPNEDEEVSQKFTEIFSKKYNVYVDYETEYVSRENEPNSSSKFHVIAKKDTSGKTLELVSDQLLIAAGRIPNSDTLDLEKTGVRVGEKGYIKTDKYLETDINGIFALGDIIGRYLFKHNANHEARYVANNILHPDKKVPVNYAAMPHAIFSSPQVAGVGFTEHELKKEGLEYQKSVYSYINTAMGHALEDRDGFVKFLADKTNGKILGCHIIGSEASILIHEVLVAMRADDNGGTIDNITKTVHIHPALSEVVARAAAGIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV9</accession>
    <name>A0A6A8FIV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hydroxymethylpyrimidine transporter CytX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_01750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000057">
        <property type="protein sequence ID" value="MRN68403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="436" mass="48236" checksum="F1C431BEA5FEFA44" modified="2020-06-17" version="1">MFPIRRLPEWGIEPIPPKDRSLRGIEYFVLWSSLGVGLLVFSAGSFLTAARFIDAVPAIIVGSIAGSLLLALAGKIGSDHAVPSLISTRPSFGIHGASIPAILNVMQLIGWTVFEIMIMSKATEILTGNRIPYYLWTILFGAFVILLGIVGPLTVVRQWLEKFAIWVVYAASFLIIIDLLMSGHLSKLLSASGGAGMSFFSALDIVIALPVSWMPLVADYNRFAKDSKGAFRGTFVGFAITNILFYFGGVLVGNSDVVAIILAIQSIFFGFLLFMFILHETTNAFADVYSSSVSTQSIFHKIKQRYLIIGFTALSTVLAMMIPISQYETFILLIGSVFVPLFGVVLSDYYIVKRRQYTQDMMYGKNVLKIGFPAIVAWSFGVLVYYLLSSLSPIYILQWSQIGATIPSFIGSSLLYLGIIQRSKWIGVLERLRYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW4</accession>
    <name>A0A6A8FIW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000059">
        <property type="protein sequence ID" value="MRN68413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="121" mass="12913" checksum="3F1764647E63C4EF" modified="2020-06-17" version="1">MFGTAENAATKLQRGPMMSLPTNCKAQIEISFKSIMLPESALLAKSIYAAIGADTKMCNRDAAASGSETKITLTKDENTNSSILLEVETPDIAALRAAINSYLRLINASLKICEASVTNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW6</accession>
    <name>A0A6A8FIW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Signal recognition particle-docking protein FtsY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">FIO04_03510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000157">
        <property type="protein sequence ID" value="MRN68748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="386" mass="41855" checksum="7F426CD9F1A89EE7" modified="2020-06-17" version="1" fragment="single">MFDQLRRAFSSATKSIGQRELSEKDIDNILFDLQLGLLESDVAQEVTDDLSAKLKKELLGLKLEKDQIKEELIRLKFQTVIAEMFSKTGKVDLIDKIKVKRELKGGPFVVVFLGINGTGKTTTVAKIANLLRKNGISVVLAAADTHRAGAIEQLTQHAEKLALKVIAQRYGADPSAVGRDAVDYSKKHHIDAVLIDTAGRMQTAKNLMDEIGKIVKVVKPDIKLFVGDSLAGNDTINQAREFFEYTKFDGAILTKTDADAKGGSAISIVYTTSKPIVYLGVGQGYDDIIPFDMGKFLQSLFGNAQKINMDNSVLRLEQTSEPIGAGKSKVEPSSSGLSAKPADELRKPVIRTTGAKETSDAVDYSIPPAGEEKSKSSPSTLPESVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX0</accession>
    <name>A0A6A8FIX0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl12p</name>
        <name evidence="4" type="synonym">rpl12</name>
        <name evidence="6" type="ORF">FIO04_05880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000354">
        <property type="protein sequence ID" value="MRN69214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="105" mass="11013" checksum="E64BDB9B9830EE27" modified="2020-06-17" version="1">MEYVYAALLLHKLKQEITEDNITNVVKSTGVTPNEVQVKALVAALSEVNIDEALKAAPVALSSSPAASAGPSTSAPSSAESKVDEEKKEEKKEEEALEGLSALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY2</accession>
    <name>A0A6A8FIY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium-transporting ATPase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kdpA</name>
        <name evidence="10" type="ORF">FIO04_04160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000199">
        <property type="protein sequence ID" value="MRN68876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="563" mass="60880" checksum="D7B103AF61E80968" modified="2020-06-17" version="1">MKSELCGCVLPLPKEQDGVNLMNPIVELIVVFGGTLSLSVPFGLYIARMISYELRPLEAPLARVENGFYKIIGIDKDKQMTWKEYSLALMLTNVIVAGFIFFMLVFQNLLPSSTHVNGLSIDLAFHTAISFVTNTDLQHYAGDQQLSVISQMIPLTFVMFVAPASGIAAAFAFIRGFIRKNFGLGNFYVDFIRIILTLLLPVAFGSALLLMLLGVPQTLQSSVTINHTLEGHNQTITTGPVASLESIKDLGSNGGGYYGANSGHPFENPNGLSNTYEMFLMLIIPLSFPIAYAKLVGKARGVSLLLTILIAFGILLAIAFSQVSGPTGLETRFGSFGTEFFNTVSISTNTGSANSALSGMSPNPVMSFLLGMFIQSVPGADGTGIMYMIIYVIITLFLVGLMVGKTPEFMNMKINPKNVKLAVFVFLMHPALILIPTVIAFTTGNAQSVLSVPAGKMTTASGYTQALYEYTSASANNGSDYLGTSANTPFWNWSTAIVMFLGRYAPIVLMLAIAGSFTVKDRKEAIEPIRTHGPLFISILLVMTFLLTALTFFPFIVIGPFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ20</accession>
    <name>A0A6A8FJ20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000378">
        <property type="protein sequence ID" value="MRN69264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="150" mass="16430" checksum="D03D4984DECF497B" modified="2020-06-17" version="1" fragment="single">MSNSTASGSTTSHYLAATIRVQNEMAKKVISENTLKKEIIYICGVDVAYRNNIAYCSAVLMNKNSMEVKESVNITLNVNHPYVPSFFMLRESEAIINILKPLKNRFDLLLIDGHGVLHPRRCGLASYIGVIIDSPTIGVAKSILCGSVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ26</accession>
    <name>A0A6A8FJ26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000073">
        <property type="protein sequence ID" value="MRN68473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="155" mass="17746" checksum="F1736FF9F2218A26" modified="2020-06-17" version="1">MAIVLKFENNNNTYSEVISYENFGMHGSILQEVCDKVVELDNSIRFAGFANNAGKIIAHKYRKGLDPLLGSNESELSFIDSALRMRTRKDMEPKLGRAIYSITLYEKVKRATISFDNEDYPILMISFDNSNKRSDHESLILDRILPLVSHHFTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ60</accession>
    <name>A0A6A8FJ60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000228">
        <property type="protein sequence ID" value="MRN68946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="497" mass="55630" checksum="07F781350DEE165E" modified="2020-06-17" version="1">MDNNMTRAGRTECSSFQTSKAKTIVKNRLQFVVGITVSLFLVAALVAASIILPLAYAQQIRSINNPATNPINHIVVIMQENRSFDNYFGTYPGANGISKGTCVPLSPDNPSVGCVKPFLSTDVISGDLPHGYQSSVVGYDNGKMDGFMVGENENPKTMTYYDNKTIPYYWDLAKNYVLADNFYSSVLSYSLPNHWYALAGQAPATSMFYFMHRPPNNDILNQQENASTIAGGNPNATANFGVNPNPTSTNLRDEVARVYLEESNLTKTVADLFMNDTYNITWKYYDHLIRAGNYKAAVSSGRAFEFWNPFSAKGSTYTPTYAPHFVNRAQIFTDLKSGDFPQVSWVTPSFPISEHPPANITSGMNWVKDVINAIMSSPYWNSTAIILTWDDYGGFYDHVPPPQIDKYGLGFRMPTLIISPYAKPGYIDHTQYQFESMLKFIEWRFSLQPLTERDLHANNLLNAFDFSQKPLPPHVVPLTGAELSAIRPYINLVRTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ68</accession>
    <name>A0A6A8FJ68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_06215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000388">
        <property type="protein sequence ID" value="MRN69281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="115"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="355" mass="41163" checksum="9115A4511D050291" modified="2020-06-17" version="1" fragment="single">MELTAPTAMSFLDSVGRNSSQTRHTYQIGLFHFQKLLETKGHTLDTIIEPLLKNEISVYTTINDFVTYLIDSLRLSNSSIAAYVAAVRSYLQFYDIDIVIKTFKRKVKMPTILEEEEESIDENDIRRILSFCNSRRLKVYLLTLATGGFRALEACAIRNCDVDFTTNPTKVHVRKEYAKTKKARDVFISDEASKAIQDWIAFKYRHRKYTPTPTKSDEDLVFTTRVITPASPQQMYSKLREDFTRVLAQAGLEKRKEGILRRTITLHSFRRFVKTVLSNEVGQDYSEWFLGHKKSSYYTNKKSERAELYITKCMKHLTFLNYDFIKSEGKTIAADLSEKDKEIEQLKAQQAKMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ87</accession>
    <name>A0A6A8FJ87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Large conductance mechanosensitive channel protein MscL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mscL</name>
        <name evidence="10" type="ORF">FIO02_10055</name>
        <name evidence="11" type="ORF">FIO04_00185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000255">
        <property type="protein sequence ID" value="MRN41369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000003">
        <property type="protein sequence ID" value="MRN68100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN41369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="120" mass="13154" checksum="09CBD7FFF30B45BE" modified="2020-06-17" version="1">MAESSPTAVKKSLKQEFFDFLMIFGIIGLAIAFVIGQAASKLVTSFVNDIITPFIGLFLPAGNLNAVKITVEHSTFMVGDLIANIINFLIIAFIVFLAYKQLSRFKLVEDKTKPAPADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA0</accession>
    <name>A0A6A8FJA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000434">
        <property type="protein sequence ID" value="MRN69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="332" mass="36674" checksum="C100B4B519D457AE" modified="2020-06-17" version="1">MKLTFRNAPHHLYPLIESKECPASSLKLFGYPLIVRNIMMAQKFMSVDTICLPDEFSDASRLIQDYFPTINLNEFCDDNRGFEKYATTISAAAPPNYHLATSVQGQHSNFEIPINSLIHNSSYSCQSHNANHNNDSNNDLVVDVLTYPWDFLKAVQDVLHNEITHTVISPMATVAKSSIINGPCIIEDDVIIDDFCKIVGPLYIGSGSFIGMSSLIRKSMMGINTRIGFNCEVAKTYFEGHDRIAHQNVILDSIIGRNVWFGGYSGTANVLLDRKNVRYQVDDNLVDTGTDHFGAVVGNNCTVGASVIILPGRQVQPNTIIQAGTIVGKKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA6</accession>
    <name>A0A6A8FJA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000412">
        <property type="protein sequence ID" value="MRN69321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="61" mass="6790" checksum="A0E855C93A5F5E94" modified="2020-06-17" version="1">MTIRADRFSNNNPKKLAISPKSPFRIEIPSHSIGNTAAVLALSFRVRYDDGNDKNLILPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB6</accession>
    <name>A0A6A8FJB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000552">
        <property type="protein sequence ID" value="MRN69525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="151" mass="16897" checksum="F91AF39EE3396AD1" modified="2020-06-17" version="1">MNFVQDTGSAWKVNFDIHNDSVAKNGSVMLAKQQLTNVGSIDTSFKPYYEPVESSVLSIRDIAREPKYLAIGAPWDSIFVAFSSIPIRVTNHETLQTTAGTFDAFTLSYTIGSKTSKIFITHQIPLPVRAEVYDSDGRLQYQYELVGKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC3</accession>
    <name>A0A6A8FJC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb</name>
        <name evidence="6" type="ORF">FIO04_02955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000121">
        <property type="protein sequence ID" value="MRN68639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="112"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="206"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="292" mass="32608" checksum="1B30AE8B41BD4DAF" modified="2020-06-17" version="1">MCKEDQTIITDLLTGEIVCSKCGLVISDKIQDTRQEWRDFVNSEEAKDRRRTGMPTSLALHDMGLYTMIGRGRKDARGQVLDASMRSTMGRLRTWDLRTQASANRNLRTAFNQLNILKDKLGLPDAIIEKTAYIYRKAHERGLVRGRQTAAALAAALYLACRQEGTPRTLKEICLISNLKRKAISREYRDMVIELDIRIPTVDPTKCIARIANQINLNQKIKQKAINIMNAATKSELSAGKSPMGLAASILYLSCLINGGSISQTVFAQTAGVTEVTIRNICRNLRNHLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC9</accession>
    <name>A0A6A8FJC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1998 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000455">
        <property type="protein sequence ID" value="MRN69384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1998" evidence="1">
        <location>
            <begin position="244"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="362" mass="41172" checksum="5F9425F27C8246AD" modified="2020-06-17" version="1" fragment="single">AYTDPSNPFVQEYQILAMACDKSISKYEFHNENSRNVNDAIQKLVSKDLIRLSSDEKFFVPNFKKAYEKLNEYSIRGIGNKVDIFFNKRIVGQRTLPQAIQELHQNAIYFLSGKRYEVKKLHYDAQQTEQPYYAELMSIPADYQYYTRAMVDEWPSIIEIYEQKKVFGIEVKYCSLKIQKKVVGYANIEIGQEMTQGKKVMFSEPIEFEFITKGFVFRAPKPIDILKYTNDEDYVEMSGYHASEHVLIEGSSMITGGASQDMGGVSLGSSGLIFIHDGSIGGNGASRVLYERFDNAIRRALRILVECPCKSESGCPRCTYSYRCGNNNEYLHKIAAIEILNKAASGQQTEIGQNVQADRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD5</accession>
    <name>A0A6A8FJD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000040">
        <property type="protein sequence ID" value="MRN68317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="243" mass="27323" checksum="6EE006DA5B0E82F2" modified="2020-06-17" version="1" fragment="single">TVKEESSLAVAFSGGIDSSLLAKLCNDIGIKVTLLTIGFPGSLDIEFSKVIATRLGLPHKLLELKKEDFHNKQRYISQKLGCGNISHIENCIAFFYLGMLARQNGLRLILTANGCDELFCGYDRFRSIYKYGNARIMQLIHEKIENEIILMKEVESITAEFGIKTKHPFLSEKFISVALEISIDNKIKGCDDFIRKHILREVAVTIGVPHEAAEKPKKAMQYGSLIHKNFKDLKTFKIANTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF4</accession>
    <name>A0A6A8FJF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000110">
        <property type="protein sequence ID" value="MRN68603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="113" mass="12466" checksum="B0480C2F680234B8" modified="2020-06-17" version="1">MVMRDHEPKVFTDLRTIILPTKFQYLTAGLSSTNNSSWGGLAVAEYWPRINGSLTLQVHVGMMKLITSNVANGHTVIVARASSLLFAIVATIFGIILTKNLMDLASKRYVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ2</accession>
    <name>A0A6A8FJJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000495">
        <property type="protein sequence ID" value="MRN69444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="193" mass="21884" checksum="C949B2404A2539A9" modified="2020-06-17" version="1">MLNMKSTPSKERKKYYRLWMPILGAAVVGIIVLVLASSSMQQQVGPPPAIRPAAPPNSLAQDSTASFVNSFEKVVNESHNLTQSYQHEAGKWKTHQYDNKTMISITNNYLLKYENLVNESKALQPPKQYQNATDLYTKSLESELQSYTHFRNYLSTNNTAENELSTRLLSDAFRYEVDSFKELKPSGLFAIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP8</accession>
    <name>A0A6A8FJP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_05535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000318">
        <property type="protein sequence ID" value="MRN69146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="537" mass="59033" checksum="D2DD33032A8BDB4B" modified="2020-06-17" version="1" fragment="single">MNNSTEQLFGQGVKRTQGEQSRRYNLLAARLIADLVKNLLGPRGMEKMFIDILGEVTVTKDGAMLLRKIDVEHPAAKVLIEASNAVDNEVGDGTTSVVVLVGALVEKAEELLDMGIAPTTVVEGYFTGLQICLESLQNIARRFTNCDREVIQGLATTCLRPKMISYTSFEENMAAKLVVDAVYAVTDFANSRVEANNIKIEDKIGNTSDTRLVNGVVIDKTIDNSAMPRSVENARILLVDEELESKRTRTDAEISIKSPYQIQSYLDKEIHTTSLKVQRIINSGANVVISQKGINAFAENNLSKAGIISIRRVKENDMLWLKKATNAQVIRDLSSDVILPEYLGYAGRVYEKFVGGDKMVFVEGCKNPKAVTILLRAGSKRLLDEYHRSVLDAIAVIRNFIVKPTIVGGGGSAEMLIATNVRKKASSISGREQIVLQKFAEALEEIPLTIARNAGMNTIDTLAQLRSKQKQHGSSTSKTKIVRWIGIDAIGRKVAEIYSQRVIEPSIVKEQIIKTAVEVSSLLIRVDDVLMAKPAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP9</accession>
    <name>A0A6A8FJP9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="4 9">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">purD</name>
        <name evidence="12" type="ORF">FIO04_01005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="4 9"/>
    <dbReference type="EMBL" id="WJXC01000030">
        <property type="protein sequence ID" value="MRN68260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="99"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN68260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="422" mass="46351" checksum="E986B1ED5469C442" modified="2020-06-17" version="1">MVGSGGREHALGWKLAQSKYAINVYYAEGNGGTFSNINIKPDEFRRLSLFAKEHECFTIVGPEIPLANGIVDLFTEENLPIFGPTKGAALLESSKSYAKHFMKENQIPTPNFSTFSDIEKAKDHVLGQTNQLVIKADGLAAGKGVVVCDTQDEALAALDLMMVENKFGLAGHNVIIEERLFGEEASFIAICDGKTIMPLASSKDHKRIFDNDQGPNTGGMGSYSPAPLIDSELYGKIIKDVMEPTVRGMSKRGQPIKGFIYAGIMVDTARKQPYVLEYNVRMGDPECQPIMMRLKSDLLEYLQSAAEEGLDSSQPLEWQNEASVCVIMAAKGYPGKYEKGKWITGLNSHIDHGIMIFHSGTKRDEQNRVVTNGGRVLSVCALGSDTKEAAVKVYSAVEKISWGNDEQYFRTDIGNATLPYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJT1</accession>
    <name>A0A6A8FJT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000280">
        <property type="protein sequence ID" value="MRN69062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="201" mass="22165" checksum="2CBB123452E520ED" modified="2020-06-17" version="1">MFVFVSVNSFSSFITKSSTIPYQKALALAARAIARAQAPSSLTPSSMTQNFTTYTDLADGISIKYPSGWEKIEYPAVPMSTTGYRVVVNFLAPIVNASDQWREYLMIQVLNQSTVKSLVPQVNTTLAGNPGYKLVYTNNEESFHLKTLEVWTTIGDHTYLLIYKAEATKYSGYLPIIQRMFDSFKVGGSAGLSNSIVSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU0</accession>
    <name>A0A6A8FJU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000569">
        <property type="protein sequence ID" value="MRN69544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="85" mass="9413" checksum="B8D2C3DBCE7389B8" modified="2020-06-17" version="1" fragment="single">MVDSKSKDDATTTPRPTNDVGNLYDALDQNFVKTVDEVTKVQPKYGQSIHNAILAQIHTVKNVIRNTILAQNQLTSGWNLPVAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV1</accession>
    <name>A0A6A8FJV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2070 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000159">
        <property type="protein sequence ID" value="MRN68753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019204">
        <property type="entry name" value="DUF2070_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09843">
        <property type="entry name" value="DUF2070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2070" evidence="2">
        <location>
            <begin position="2"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="565" mass="61607" checksum="4BD1C024FB127739" modified="2020-06-17" version="1" fragment="single">SYKISYLISLLGIAVVIILSYTNIFKTDLSMLALHLPLGLAAMTGSVFLDFYALRGRSLNKITKAFHVSAFASLLWALTIILGIVFHTLLSKTTSPTSYVVEGMLLAVGMRIGIFVSVFGTGIPRSILSAFIQPVLLMLAFVPLGFYQSILSMTPGFAYGSIFIILALAWARLADKAGSPSVNSTFTVLQAFLAAWTENSSDRMEEIAEARSHKEKVLTYIAKFKSPSAQVSIILPDLHPGPFKPIGGSNLPYLLFSEYSRNALILHGVSNHSRNIPSKSEVDNYIRTLSHATVSERCETGTIPFQTKIGRSTATGIIFGDTAIVILSMAPVGMEDVPESIRLALEKYSFHLGLKHILVVDSHNAMGEELKKSDCESLLSAGEICLKELINAPRYGFKVGYASLDDISCNTTGLTEELGQSGLATIVFEVAGNQYVIGWADSNNMDNSLRDNIINKLSRNGIQTLELCTSDTHSTSGKRTRQGYYALGKTSNHDDIAEIYLQLSKKSIEKAASAGFELLSSESMIKVMGNRQFDDYAFALNRSMNITKIFLAITSAVFFATLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJW8</accession>
    <name>A0A6A8FJW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000043">
        <property type="protein sequence ID" value="MRN68330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="310" mass="34286" checksum="F33C02E27C990CA8" modified="2020-06-17" version="1">MASIKLAVVSNIVLDSIRDTEGIVTESLGGPAGYCGLTARRFSFDVSLATKIGTDFPPAYKRFLLAEGIMLTDCQLSHDRDTTRFRLTSNRDNNNIRSLFLSSKCAQITIDDIEKIETDCWLVSPVIDEVPEDVLRAIILHGGRRGFVMVDPQGYTRIVNSSGEITSVNKLSLNLSGVSAIKADKTELALLTGGLEGLPAMQYLQSRTGIKFVISTEYRIIHLLYRGMHYWIQLKDIESPDSTGVGDILCSAFCCAYIKENDPLWAFSFGAGAVRAALETRKIGLDKIPSKSKIEQSASYYYNTISFRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK30</accession>
    <name>A0A6A8FK30_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000333">
        <property type="protein sequence ID" value="MRN69178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="487" mass="53125" checksum="A77DCB01BF1B4748" modified="2020-06-17" version="1">MNKQPEAKELTTVTTIQQLSNRIQNGELSPSELVGVCLDKIKKFDSSLNAFITVLEDHARQEAANAEKQIKQGIYLGPLHGIPFSIKDVIYAKGVRCTAGSKIMSDYISKIDATSVVKMKKAGAILIGTNNTHEFACGITNVNPHYGSSRNPWNTSKLSGGSSGGSGVAVAACMVPVSLGTDTSGSIRVPSSLCGVVGLKPTYGRVSKYGIVDLAPSLDHVGCITRSAWDAAAVLQTIAGRDPLDPTTEDRKVPDYTKIIEESNSDKMSIGIPKEYFFDYIQPEVEDVFHDFIDAIRSMGITVSDVNLQESDKIYESWRSIRLGESAEIHSKWLQTRPEDYGEDVLKMLIQGTEVSAVNYIQAHKFRKEVRNAFMKVLKNVDVVIVPTTILTAPSFDEPTVSIRGKTLEVYQALSRNTIAFNSTGLPAITIPAGLSKDKMPVGAQIVGAPFEEVKILSLAYALERVNNYPFKLTPICTESSPKTERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK45</accession>
    <name>A0A6A8FK45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000194">
        <property type="protein sequence ID" value="MRN68863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="129" mass="14279" checksum="3A9DF8CCD14E51BD" modified="2020-06-17" version="1" fragment="single">MKSGRLNELSITKPLSIGIIGGGQLGKMIALEAKRMALKVCILDPSRCCPASTVSDELIVADFKDERAIRNLASKSDVITYEIELANTEALIDLASKNRNFVNPSPETLRIIQDKYKQKSFLKENNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK54</accession>
    <name>A0A6A8FK54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000197">
        <property type="protein sequence ID" value="MRN68873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="239" mass="26782" checksum="78701891DD5FB010" modified="2020-06-17" version="1">MRKAVCIVSGGLDSVCTAAYLREEGYRVYMLTFAYGQRARYEIQAAKRFARILKIEDHRIVDIAFMKEIYGRTNVLTDTKQVLPQHFDYSIVVPLRNAVFITIASAWAMSIGAELVAYGAHTGDERYPDCRASFIKSITNTLNLGESDGIRSGTRQKITVWSPAVNGIDKSGLLSKGYKHLGDRIFDTWSCYSNGLREKGKNPIQCGRCESCINRKIAISNAGVEDKTRYANEPKYNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK61</accession>
    <name>A0A6A8FK61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF354 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000399">
        <property type="protein sequence ID" value="MRN69296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="143" mass="16132" checksum="07DB3674AD7CB6A5" modified="2020-06-17" version="1" fragment="single">NSINIVILCRYEEQIRQLVERYEARAFILRNVVDGIPLIASSDVFIGAGGTMTCEAALLGTPTISISPIRFYVEKYLVSTGLVKRASNSIELVRLTNGMLKDKKYKKKQKRLAAFIFDKMEDPIDKMLSYLNISTQHSKDGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK79</accession>
    <name>A0A6A8FK79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000409">
        <property type="protein sequence ID" value="MRN69316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-Thr_ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="80" mass="9275" checksum="DA5E057A6FE11042" modified="2020-06-17" version="1" fragment="single">MRLLQLHSDFVEYQPIAKEIREAEENVSSSKVRFEDLVVTLVAIENGDDENLARIAVNEIERYLATVKSKRLLIYPYAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKA5</accession>
    <name>A0A6A8FKA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000421">
        <property type="protein sequence ID" value="MRN69336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="125" mass="13866" checksum="516760B4E15CF058" modified="2020-06-17" version="1">MAMANKVRVLIIDDNEDVTEAVSDYLESIGDSCTSLNDGKQGLEVIKKEGHNYDAIILDLAMPDFSGYDVLESLKNETLLDPNKIILFTASSIPDKEAEAIGVKTILRKPLSLEELEATINRFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKB4</accession>
    <name>A0A6A8FKB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03245</name>
        <name evidence="2" type="ORF">FIO04_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000084">
        <property type="protein sequence ID" value="MRN61058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000121">
        <property type="protein sequence ID" value="MRN68637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="118" mass="13578" checksum="267D1562995FD50D" modified="2020-06-17" version="1">MIIKSQKVKRALLTALADDELVEIMGSVMHHSKSFNDITRDNGNIPRTTAFRKIKWLLNEGLLIVDKIVITPSGKKFSLYHSTLKAINVRYENNDVIVEAEQNFDIAKKWLEKFFSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKG6</accession>
    <name>A0A6A8FKG6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">FIO02_02445</name>
        <name evidence="5" type="ORF">FIO03_02565</name>
        <name evidence="6" type="ORF">FIO04_06825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000024">
        <property type="protein sequence ID" value="MRN39887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000061">
        <property type="protein sequence ID" value="MRN60926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000463">
        <property type="protein sequence ID" value="MRN69396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN60926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="309" mass="34840" checksum="24D0D86D47321178" modified="2020-06-17" version="1">MSSLEFYTPDDIPPEVQAYGSELKQLQVGRAGKIGALTLLLEQDQERGKTVIKEQYSKVPLFTQRALYLEESLPSMAYIHIMSPSGGILQGDRYRMDIVLKNKACAHITTQGATRVYRMERNYATQIVNVFVDEGSYLEFVPDQIIPYRDSRFYQTVNLKVHDNGTMIYSEIIVPGRVASGESFQYDICYMKALAKNQKDTLRFIDVAILEPKKRNLKTLGILDTFDVVGSTYILTKADYVKELKDEINSGLYKFTQISGGASILPYNSGVIVRTLGNVASDLRNAIYEIIKITRRIILNASFSGIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKH8</accession>
    <name>A0A6A8FKH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000094">
        <property type="protein sequence ID" value="MRN68550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="113" mass="12420" checksum="E271E056391D767D" modified="2020-06-17" version="1">MLQTAYHNPSLALYASLWFQIRAAISTMLSKPIREDILGRIVRAAVEFDVEKCDAICEAVPGHDRDGEVRDSTKQGTAKVVVHGERITGYTTGISFYNHSVGLTNDDLKALIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKK5</accession>
    <name>A0A6A8FKK5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Box A-binding protein</fullName>
            <shortName evidence="6">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">TATA sequence-binding protein</fullName>
            <shortName evidence="6">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tbp</name>
        <name evidence="8" type="ORF">FIO02_11040</name>
        <name evidence="9" type="ORF">FIO03_01800</name>
        <name evidence="10" type="ORF">FIO04_05015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum02</strain>
            <strain evidence="9">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000318">
        <property type="protein sequence ID" value="MRN41564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000037">
        <property type="protein sequence ID" value="MRN60777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000272">
        <property type="protein sequence ID" value="MRN69043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04518">
        <property type="entry name" value="TBP_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033711">
        <property type="entry name" value="TBP_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="6">
        <location>
            <begin position="101"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN41564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN60777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN69043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="187" mass="20681" checksum="60B029EA61546967" modified="2020-06-17" version="1">MPQTKPIVSIENVVASATVNQTVNLNLITQIFPDVEYHPDQFPGLVFRLKSPKTATLIFSSGKMVCTGAKSEEQAIKAVRNVVQKLKKGGIPVEHEPQIEIQNIVASASLGGKIHLELAARVLPRSMYEPEQFPGLIHRMLDPKTVILLFASGKLVCTGAKKESEVYRAVHNLHTLLEEKNLMIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKM4</accession>
    <name>A0A6A8FKM4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000281">
        <property type="protein sequence ID" value="MRN69063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="130" mass="15386" checksum="2F02F22BEB3BF314" modified="2020-06-17" version="1">MFESLDFLYVPAPNIQESIRYYTKVLEGELLWKIHAYGVWVACIRLSDKEPYILLADHIERKDLMLIYRVDNLDKASSELRARGWREEKSLEIPVGPCLTFRDPADNSIVIYENRRPHVMRDFKGRIDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKS2</accession>
    <name>A0A6A8FKS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000486">
        <property type="protein sequence ID" value="MRN69428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6132" checksum="CE21F4E12E89B50D" modified="2020-06-17" version="1">MTILRWAIEECELISAAGMPDDYTQEEYDIKTTEPVVYAAASTNTTLKCRNTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKY5</accession>
    <name>A0A6A8FKY5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartokinase</fullName>
            <ecNumber evidence="3">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_05700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000334">
        <property type="protein sequence ID" value="MRN69179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="328"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="479" mass="51703" checksum="793833E4C5E8B009" modified="2020-06-17" version="1">MRLVMKFGGTGVNSANKVKEIANLIKAQHHDSTNDVVVVVSAIRGMTDDIFSITDNIKDGQKVSVENFMKKVRPFHLDILRNAITNEGIMKKAELVVTQLLDELENVLAGIVLLAEVTPKSLDYLLSFGERLSTPIVSYTLQDIGIKSEHLTGREAGILTDSNFGEARPLMDTTKLRVAHKITPMLKDGVVPVVTGFIGADQNGITTTIGRGGSDYTATIIAASIKADEVWLWSDVNGLMTADPKIVKDAQVLKEVSFAEAMEMALFGAKYIHPRSFYPVIDSNIPIRVRNAFNVNHPGTIITQRPAKASQKIVKSISAIRHTALIDVSGGDMAGSPGTASRIFDILAKNRVNIMMISQSPSESSISMVVRKSDLDKATTALELNLLGKIIKKVNVNADVAVIAVVGSGMRGIKGVAAKIFGSVARRNVNVIMIAQGSSELNLAFVVNDDDCQAVVRALHTEFKLVSSGARHKNIPRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL15</accession>
    <name>A0A6A8FL15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_05855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000351">
        <property type="protein sequence ID" value="MRN69209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="266" mass="29869" checksum="A53337BBAC62597A" modified="2020-06-17" version="1">MKNFDNVPKPFESGSTPLLELKNITKEYVDDRGKKIVVLNRINLSINHHEYISIVGPSGGGKSTLLRIIMGLETCTTGEVLLKGEPLKGKVDPHMAMVFQSFGLFPWLTVVENVEFGLESNHIPKDERRKKSLSIIQEVGLEGFENAYPRELSGGMKQRVGIARALVLDPEVLLMDEPFSSLDPLTAEALREEILKVWSNRLTTPDVVIMVSHNVEEAVYLSDRVVVLSHRPASVVKEVHIDIPRPREKRDTSIYDYTDQITTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL28</accession>
    <name>A0A6A8FL28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000356">
        <property type="protein sequence ID" value="MRN69219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="315" mass="33789" checksum="75BE418E8E390843" modified="2020-06-17" version="1">MAVALTICISCGGFVTVQHAYSESPIKVMAQPPFTGSDGKLNVIGIVRNSGNMPVEVNLGLNIVARDSGLVTTIKEPTYGRVIYPSNVSPFKFAVEPSWSLSGGPFILNSKEVLTPYYKVLSLSYSNMPVGNDKALIGKAKNVSPVDLHNVTILASVHKNNGTQIDSVKSQLFPVIRTGQTVAFAALPDPAIKSNIAYFSCADIDVGNNSALNTLGIGNGQFIAYQMSGVVQISDFKYDNTTDSLVFGIKHYNPAGGPFSLKIPEMSKNQPVSVILDGKLYTEASVKMDGKTVRVDFFVPPDNHQVQIKGIRNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLB9</accession>
    <name>A0A6A8FLB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000188">
        <property type="protein sequence ID" value="MRN68850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="51" mass="5682" checksum="8BD5E0F787F39628" modified="2020-06-17" version="1">MKKQPLLTTSIRAVGVVGTVAVLRTIYYERGYKDGFKDVHNDVIQTCPGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLD7</accession>
    <name>A0A6A8FLD7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000246">
        <property type="protein sequence ID" value="MRN68987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="140" mass="16109" checksum="80DEE89D651E42E4" modified="2020-06-17" version="1">MSEPVAKILKKRTFAFLGTVMKDGSPHVTPTWVDVEDNTILVNTAEGRIKQKNISRDPRVSISIVDDENPYSMVTIKGRVIEQSTQGADEHIDKLARKYLNIDKYPGHSPQIKRVILKIKPERVFYLAPRYEQYLKKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLH6</accession>
    <name>A0A6A8FLH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF861 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_04440</name>
        <name evidence="4" type="ORF">FIO03_01985</name>
        <name evidence="5" type="ORF">FIO04_04980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000060">
        <property type="protein sequence ID" value="MRN40273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000044">
        <property type="protein sequence ID" value="MRN60814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000268">
        <property type="protein sequence ID" value="MRN69037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="2">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN40273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN60814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="121" mass="13506" checksum="89862E1140F5CDCE" modified="2020-06-17" version="1">MTTTAKLQKKSMKSPDETRSFDKGKVEIAKVGETSIGRAYFEPGWSWEKCVKPIVKTESCQAPHTQYVISGRMRVKMDDGSEEEFGPGDVGYLPPGHNAWIIGNEPFVAVDFTGMKEYAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLS7</accession>
    <name>A0A6A8FLS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb</name>
        <name evidence="6" type="ORF">FIO04_04795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000251">
        <property type="protein sequence ID" value="MRN69000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="229"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="314" mass="34861" checksum="B00F119977FFA10B" modified="2020-06-17" version="1">MGAQTIMPPESKLNERNDATYCDQCKGYTVIFDMVSSEYVCSSCGCVANDKFFNNEHSSGYSGQSGFSDRSRTGMPESLAIHHKGLSTLIGMGDTDARGKALEPEQRMKMQRLRTWNNRSQLNDSISRNLEKALKFLNNFGDKLYLSQAVMESAAYIYRKAAIKKLAKGRSTLGLVGAALYAACRETATPKTISDVASVCNLSSKDVMSHYKLILRELSLQMPVLHGPDYVTLIANRLDLSEKTKREALKIFSEVQQNRISIGKNPRALAGAVIYLASQTCNEFLRQVEICQVADISTVSLRKRCKEIKATLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLV8</accession>
    <name>A0A6A8FLV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000339">
        <property type="protein sequence ID" value="MRN69187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="66" mass="7193" checksum="CDF8E238A0A44DAD" modified="2020-06-17" version="1" fragment="single">MALKLADYKTNVHNDWCPGCGDFGILSAIQMSLADLQIPMHKATVFSDIGCSGKTAHFIHTYGIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLY6</accession>
    <name>A0A6A8FLY6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">purE</name>
        <name evidence="6" type="ORF">FIO04_05895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="WJXC01000355">
        <property type="protein sequence ID" value="MRN69217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="5">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="158" mass="17102" checksum="6F08D41BEF42F4B2" modified="2020-06-17" version="1">MPNEKDLEVMNESVKTLRTFRVCCEVVVISAHRSPEQMIEYAKSARKRGIEVIIATASGAAHLPGMIAAFTTLPVIAVPLRSSFLDGLDSVLSILQMPIGVPVATVSVNGARNAAILACQMLSLHNENVRHQLDKLKTSLAEQVKQEATNVRSKSPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLY8</accession>
    <name>A0A6A8FLY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000555">
        <property type="protein sequence ID" value="MRN69529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="47" mass="5401" checksum="604D30EC16F7A115" modified="2020-06-17" version="1">MSISRSLSGFLFDPLSKGMETKPAEKLEWNWIVDNNKMVMTIKKANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM02</accession>
    <name>A0A6A8FM02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_07555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000564">
        <property type="protein sequence ID" value="MRN69539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="313" mass="36118" checksum="6418AD7BAAE9B855" modified="2020-06-17" version="1" fragment="single">MVNALTRQNGPQYFNHPLIKKHSIEFRVYQNNISESARNKNTLVILPTALGKTVIAILVCAEFLYNYKSKRVLIMAPTKPLVAQHMNSFFSVLRMPEDCITAVTGKNLPPTRMAIWNRKEVRIVFATPEVVKNDLAENRLSLSEFSLLVFDEAHRAVKDYAYTSIARYYVQQSSHPVILAMTASPGSEKRRILEVCNNLSVEQIEYRSEEDGDVKPYINPIDVTWKWFTIPQEYKYISSTFRGMLEDKLQFLIERGLLRKKHPQWIFKSDLISLGEEIQYKLELTMEELRGPLYAALVQQSSALTLMYCAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM12</accession>
    <name>A0A6A8FM12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000572">
        <property type="protein sequence ID" value="MRN69549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="103" mass="11205" checksum="88D2BB0E271D8B39" modified="2020-06-17" version="1" fragment="single">MSMLVPSDIPMNCLGVDSMVTFIAPTFVNDKPVERIARFADIDKVVEWNIRRPKNPAEVMDAPAMTGFIDPSFDIIKPDVGPNTKSIIANGNCMLPVLTASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM19</accession>
    <name>A0A6A8FM19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000292">
        <property type="protein sequence ID" value="MRN69090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="176" mass="19566" checksum="8AB3D635B06C6E94" modified="2020-06-17" version="1">MKLERSEKMERPSTLARLKKLLPTLSMRFILMVSVIGFFVGVTHLNSAYSSSSLLQTNKVNVQQEMNDCCVPILLAPISTTADNVYMAWTNNDTGHWKVFFAKSGDGGKTFRTIVLNAPSNTGHVVHENTEITASGSRVYVTWWTNQTGTFMPVFRASNDSGNTFGKPVILNTTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM58</accession>
    <name>A0A6A8FM58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000312">
        <property type="protein sequence ID" value="MRN69130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="101" mass="11391" checksum="9A486A2C0E25F324" modified="2020-06-17" version="1">MGDEKKCHIVEGEITNNGISKFFSPKGDGMLPGDIVWDFIKKTGRKLDYEEGYVINKGAEGFQCQDCKYYMYSEKCLLIKGTFRPEMSCGFIVKIGNGTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FN37</accession>
    <name>A0A6A8FN37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_05070</name>
        <name evidence="3" type="ORF">FIO04_06995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000073">
        <property type="protein sequence ID" value="MRN40397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000487">
        <property type="protein sequence ID" value="MRN69430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="247" mass="26852" checksum="74FD0A98894FC8C1" modified="2020-06-17" version="1">MLENKVAIVTGASSGIGYATSLALSKAGVRVAVGARRIDRLQELEKQIIKNNGGEIFIQKLDVTTKSDCDSFADAVVRKWGKVDILINNAGLMPLSYFANRKVEEWERMIDVNIKGVLYCTSAVIPYMLDKKSGHIVNVSSVAGRIIFAGGSVYCATKHAITAFSEGLRKELSPRYNIRVTCVEPGAVSTELLESITDESMAGFIQASKNMETLGSDDIANAVLYAIQAPNHVNVNEILIRPTAQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNJ5</accession>
    <name>A0A6A8FNJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000565">
        <property type="protein sequence ID" value="MRN69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="264" mass="31032" checksum="2E815F47D550F44D" modified="2020-06-17" version="1" fragment="single">LRYYSQFFNTAEMDSTFYNRFYSKMTKGTFIGIVKATPEKFQFSIKVPETITHDKRLDIDKGAITDFEEFLDKISPLKTANKLAAILIQLPPSFTVNDFKNIESFLDRLPKGNNGRSNYDYAIEFRHPSWKTEGPWEMLKHYNISAVLTDSPSKENLQFLSDVIVTTENHSFIRFHGRNTKSHYWYDYLYSKEELKPWVEKVSQIRNQTKVLRVYFNNHYGGNAVVNALQFREMTGTQLSDSETRAVKHAETYFSEQHQQKRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFW2</accession>
    <name>A0A6A8FFW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000008">
        <property type="protein sequence ID" value="MRN68134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="232" mass="25603" checksum="461F0D850357B2A2" modified="2020-06-17" version="1">MPSTVLLAFGQNSQSTTNFAQSKYEVIKTIRSLRFDFPYTASNNDRTHPLVYTFVKPISESWILNVDNNVSYATRPDAKTVIKLQEPAPSEKFIEIAMYGDSASNRFWAAVNTREAGYIRLYDKNGIDGWSATQPIIIGYDSNQGLSISSGAKVLVDRLSVNGFTLGSIAVYGKDDPNSPPNTYSGNISFEVLWGKPADSPIYYLPLVMLVGVGGVLIGLLVFKKRDKIEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG56</accession>
    <name>A0A6A8FG56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="1">6.3.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000030">
        <property type="protein sequence ID" value="MRN68261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="180" mass="20566" checksum="CC0C1E36389F5995" modified="2020-06-17" version="1">MRKIMLEKRNSLSPDDIETKSAAIQQRFAHSDEFNHSRMVASYYPVGSEVRTQKIVNIALKSNRLVALPRTIGDHIKFYRILLNTDLTAGKFGIKEPSISSNSCVSDEIDLLLVPGIVFDTNGYRIGYGYGYYDRFIARKKNSIVSVGLAYEFQVCEKVPRSQNDQKINVLVTEKRMLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG59</accession>
    <name>A0A6A8FG59_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="5">HPPK</shortName>
            <ecNumber evidence="5">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="5">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="5">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mptE</name>
        <name evidence="7" type="ORF">FIO04_00820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000024">
        <property type="protein sequence ID" value="MRN68224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="6">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="210" mass="23630" checksum="9E2A2C095AFD4CC4" modified="2020-06-17" version="1">MIKKKTIDIKVLQRKIARRHVMAIGAGDSLISNIKFIKKNRKFVKIVADGATQALIENHITPDIVVTDLDGDALFLRKAERAGAIMVVHSHGDNVEELKKLVPTFKRVIGSTQVMPVENVYNFGGFTDGDRCVFLADEFGAKEIVLVGMEFGDRIGEHSKKIVKNIELKKEKMKVGKRLLEILAKRSHSRLFDTSQRPIRGFTSLTIQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG85</accession>
    <name>A0A6A8FG85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L7ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000027">
        <property type="protein sequence ID" value="MRN68244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="2">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="87" mass="9383" checksum="44414D584B56DF03" modified="2020-06-17" version="1">MLKIEKALKEAVAGSKFKCGHKQALQSIKGSKLIVISRSADAKTRRELEQQAPAAGVPIYQFDGNSTQLGKLCGKPFRVAVVALKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGB6</accession>
    <name>A0A6A8FGB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000069">
        <property type="protein sequence ID" value="MRN68455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="77" mass="8823" checksum="6CD531D451568D71" modified="2020-06-17" version="1">MANDKTADIQARIETLLKDEPLKSYSKEEIIDKLSDSYPNMEVERMLGEMEVSSSMTNSQSHVDSTCRGGTVYFQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGF5</accession>
    <name>A0A6A8FGF5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_02225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000080">
        <property type="protein sequence ID" value="MRN68495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="189" mass="21792" checksum="6492CCF6646EB64D" modified="2020-06-17" version="1">MGRKKKTDLTPFFQHVLRLKHVKRAGWISRAQIGNPESVADHSYSVCAISMALSDMLGLNTERVMKMAILHDLPESIIGDFVPGEVTKKKKRAEENNAIETILQSIPPCIRSDYKGIWLEYLLNKTDIARLVHTVDKLEMAMQARQYVSEGYPKHLLAQFLDFPKKYMMNYKHEIISQIQNALKPRRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGG9</accession>
    <name>A0A6A8FGG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="283" mass="30531" checksum="2BCCFABF07AA31F3" modified="2020-06-17" version="1">MKYIQLEPQADIAIIKINRPEALNALNTDVILELSRTIDIVGVDDGIKAVIITGVGERSFCAGADISYMVSITPIMAEKYASAAQDVLNKIEKLEKPVIAAINGFALGGGCELAMVCDIRIASSNAKLGQPEVTIGIPPGWGGTQRLLRIVGPSKAKELIFTGKTLAAEEAEQIGLVNKVISLGPDDVLPPDAPDGDSVKEKERSNQVARILNKKLMEECLALARQITNNSFIAVKTSKILINKGMDADINTGLRLEIYGWALCFAHEDREKMMSAFLNKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGW9</accession>
    <name>A0A6A8FGW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_00305</name>
        <name evidence="2" type="ORF">FIO04_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000005">
        <property type="protein sequence ID" value="MRN60485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000021">
        <property type="protein sequence ID" value="MRN68206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN60485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="104" mass="11561" checksum="949E7A1D701088B5" modified="2020-06-17" version="1">MARTAPTIPIELSNGVTVVAYSNMTFYLNSTNSHYHLKGLIKDILPESRGFISVMIDFRNQSTVTSVHSILYTLHGPIDSNTTVPFDIDTGYTQAQQRLEALIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGX3</accession>
    <name>A0A6A8FGX3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">psmB</name>
        <name evidence="11" type="ORF">FIO04_03185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="WJXC01000135">
        <property type="protein sequence ID" value="MRN68685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5025735111" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025735110" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="222" mass="24625" checksum="6054583DEE853958" modified="2020-06-17" version="1">MYQQGNDNRYEEYIAEHIKKGTTTCALTCKDGVVLAADTRASAGFFIADKHVMKIQKIDRHIGMTMAGGVADAQNLVDIMRYNANIYRLTDKDPIPIKSAARLCSNVLFNQRYYPFFVQIILAGVDKTKEEGQIYNIDLFGSMTSEKFISTGSGSPVAYGYLETEFKENLTVNDAYKLAIQAIAAAIRRNSGTGDGINVVIIDKDGYRELSKEMKKAVSAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH19</accession>
    <name>A0A6A8FH19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO02_00640</name>
        <name evidence="5" type="ORF">FIO04_00015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000004">
        <property type="protein sequence ID" value="MRN39541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="PTHR21231:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="252" mass="27878" checksum="9112B49FD297F2A7" modified="2020-06-17" version="1">MNAIFITGTAGSGKSLLTSRLLQWYVDRKSFPISVNLDPGVVNLPYKPDVDVRDYIDINTLMETYDLGPNGSLIMASDMIATRLDEIQDEVNNLNPDYILIDTPGQIELFAFRASGPYFVSNFQSDNKVTLFIYDGMLVSSPINFVSIGLLASSVRLRLKIAQINILTKRDLIVDKLRDILKWSSSALSLESSLDNEKDAEYSLLSKDLVRSMSKGGFHQNLIAVSSMTLNGMVNLSAALARIVSQGEEIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH44</accession>
    <name>A0A6A8FH44_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_00175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000003">
        <property type="protein sequence ID" value="MRN68098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="153" mass="17127" checksum="44439CE92C346B92" modified="2020-06-17" version="1">MISINKTDVNNKKTLVNCVKDLYRMGFTSPVSGNHSVRMQNKKWMWITPSGVPRYNLQEEDLVKVQLETGKTLGRVKPSIEWYMHVSIYKKLGKVNAIVHTHSPHTLGIAISGIDKFQHIIEEAKIVVGNPVIIQNKPSGSTELANMVSEAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH82</accession>
    <name>A0A6A8FH82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmk</name>
        <name evidence="4" type="ORF">FIO02_03155</name>
        <name evidence="5" type="ORF">FIO04_00500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="WJXE01000035">
        <property type="protein sequence ID" value="MRN40027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN40027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="253" mass="29012" checksum="2C0625DCC420E261" modified="2020-06-17" version="1">MEYYGKGLPYLDETRIKGRLIVIEGPDASGRSTQIIRITSKLEADGHAVLNTGLRRSELISQGILEAKRNFVLGKRTISLFYAADFADQLENKIIPALRSGYIVLADRYIYTLMARDAVRGISIRWSHNLFGFSIKPDLVFYLDVDPKELVHRVFQKKASLDYYESGADLGLSDNMFESFLIYQRLVAREFRKMQKRYGLVFINGNRSIEEIGTELQKKIDDFVNFRSLDDTNELGLIGRKTLPGRKQELNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH94</accession>
    <name>A0A6A8FH94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_01890</name>
        <name evidence="4" type="ORF">FIO03_01445</name>
        <name evidence="5" type="ORF">FIO04_01350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000017">
        <property type="protein sequence ID" value="MRN39783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000027">
        <property type="protein sequence ID" value="MRN60707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000042">
        <property type="protein sequence ID" value="MRN68326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="2">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN39783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN60707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="152" mass="17119" checksum="6B443E3E21B46AB7" modified="2020-06-17" version="1">MAYLVVRIRGTVNVPSWATATLTYLNLNKKFRATLIPESPQSLGMLRKVKELVAWTSADPSIVKELLEKKGRKAGFEPVSDSDLPKEYDDIDAFAAAISENRVSMSEIHNIKPWFALNPPRGGFKRKTKNQYNEGGILGEDKELVDIVRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHA1</accession>
    <name>A0A6A8FHA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO03_01820</name>
        <name evidence="7" type="ORF">FIO04_00605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000038">
        <property type="protein sequence ID" value="MRN60781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000017">
        <property type="protein sequence ID" value="MRN68182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN60781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="359" mass="41831" checksum="0C9A046A4FCE25CC" modified="2020-06-17" version="1">MVVDTIRTIKLLGKWSGNRIIGRRRPLIAVFSLTHYCNFYCPMCPFGDSDKDGQIKIARKNDLSTEQWKDIFHKISKYCIWSIVEGGEPTSRADFMELIRYLYKLQLPITLITNCSLLHTIDLDELKRYIQFITCSIDSMFEEPYCKVRGVPPRVFRKVMDNLGLLIEYKVPHYFNSVITKYNTEEFINQTYFDRAKELGSNAVSFTFVEDRSDVNFSLLPDRQTMVKVCESILGYMKTHTSPQIMIPAQYFEQIIEHGRGMFEECGVWKSIFVNGNGTVMVPCWKFNSPDNTYNLLEKSVEEIWSAPQWDIARTCHDCQVLGCIWYSSQPITTFAQNYMKGLRKMISQQKPEFAEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHB2</accession>
    <name>A0A6A8FHB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000013">
        <property type="protein sequence ID" value="MRN68168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="12351" checksum="109C428AB10E4E79" modified="2020-06-17" version="1">MSNTQEAYIQTLRQIKDAEDGAEKEIEARKSEVEEEIRNMQIQIEKLIEASKAEGENLVIKSIEESRRKALADADSIIKEAQIKSKNISAQVNNQTIQKIIDILLRGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHD8</accession>
    <name>A0A6A8FHD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_03065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000128">
        <property type="protein sequence ID" value="MRN68661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="319" mass="35328" checksum="594FC4AC1E011E37" modified="2020-06-17" version="1">MKQTENTGPAIELNRLTKRFGDFTAVDGFSLTVRSGEIFGLLGPNGSGKTTIINMISGLSKPTSGEAKVLGHNIIHDTRVVYAALGSVPQETALYEELDAWTNLSIHATLYGVRRSERDRKITDMLNLVQLYERRHSRVSSFSGGMKRRLALARALLHDPLLLYLDEPTLGVDVQSRRAIWNYILDLKKKEGKTVLLTTNYLEEANALCDRLAIIDHGKLVALDTPINLKRRYGDTVMEIETASSVSPQLSAKLSILPGVSEVIQKDKILKVTMSGDELSLTGQLITLVTQEINIKKISQREPNLEEIFLSLTGSGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHK5</accession>
    <name>A0A6A8FHK5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_03375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000148">
        <property type="protein sequence ID" value="MRN68721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLXc" evidence="9">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="348"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="606" mass="67998" checksum="6BEEAFC4E8A12728" modified="2020-06-17" version="1">MKNANIASILRDIAFLLEMEEEEDNSNIVFKIRSYKRASDVIANLSSNVEEVYATQGLKGLMQIPSVGKAIALKIEEYLTTGKIQYLDELKSKTDIDIDGFYGLEGIGPKTIKIVYDKLGIRDLSGLEKAASGGKLRSIRGFSEKKEEVILKKIQLFKKGRSRYLLGEVYPLIKQIETRLLKFNGVKNAVVAGSFRRMKETVGDIDFVVACNDVEKVMDYFVSMPEIDEVLGKGSTKTFVRLNNGMDADLLVVPEESFGSALQYFTGSKEHGVAMRKIALAKGLHLNEWGIFDNSQHRIAGSTEEEVYQTLDLEWIPPEMREYLGEIELAKKGAKGLPKLIEYNDLKGDLQVHSNSTDGTMSIEEMALAANEKFGLQYIVITDHTKSLKLTNGLDEKQLLDQANRIAELNDRIRRVPDKTERQRINGADLSASTPRTKPNNFRILSGAEVNIMRDGSLDIANNVLDKLDIVGAAIHSNFSQPIEVQTDRLIKAARNPSVDIIFHPTGRRINKREGYPVNIEKLVDIANDTNTILEIDAHYDRLDLKDEYVRMAIQKGVKLVIDSDAHHPVHFGFLKFGIGQARRGWAEKSNILNTMPVDELLRCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHN8</accession>
    <name>A0A6A8FHN8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps14</name>
        <name evidence="4" type="ORF">FIO02_11780</name>
        <name evidence="5" type="ORF">FIO03_04095</name>
        <name evidence="6" type="ORF">FIO04_01200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000370">
        <property type="protein sequence ID" value="MRN41703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000119">
        <property type="protein sequence ID" value="MRN61223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_S14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="40S_S29/30S_S14z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_S14_type-Z_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="PTHR12010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN41703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN61223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="61" mass="7134" checksum="B94739E0E6B949AF" modified="2020-06-17" version="1">MITPKPRDYSETGRKKLAHGKGTRWCKRCGSYTGLIQQYDLMLCRQCFREVALSLGFNKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHR1</accession>
    <name>A0A6A8FHR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000080">
        <property type="protein sequence ID" value="MRN68496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="107" mass="11978" checksum="75238BC14E67B28A" modified="2020-06-17" version="1">MQYFTALKLGEKRVKAAQDVLTKYTGHAMPALALKDNKDNKWEPVGEENLFAVVKEASGYMIAICDKNGVAKSIAQWFTEDTKNEIIAKIKAEQNMIEYLGKLSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHR2</accession>
    <name>A0A6A8FHR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000248">
        <property type="protein sequence ID" value="MRN68995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="54" mass="6107" checksum="8E2780FAB4125283" modified="2020-06-17" version="1">MTRIHNPITSRALSINYVGIGTEVFQIAFIIIAAIIIVRETRRAPQISQKEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHT0</accession>
    <name>A0A6A8FHT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000085">
        <property type="protein sequence ID" value="MRN68516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="180" mass="19710" checksum="815E037EA1110146" modified="2020-06-17" version="1">MTLNKQNMGNKRGGSNENLKRDDSYMGMNRRKRRRNMMLAIPIVAAVVALVAVSAYVYSAQAPSKTMVLHIHPQLGITFDGQPLTVPSQIGIDQSLWKDHSLDQYGMSGMAPLHTHDASGTIHVESNANRNYTLGEFLNIWGGLDTNGKTVKATADGKSVSGYKDLILRDGEQINLQVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI24</accession>
    <name>A0A6A8FI24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03030</name>
        <name evidence="2" type="ORF">FIO04_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000077">
        <property type="protein sequence ID" value="MRN61019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000065">
        <property type="protein sequence ID" value="MRN68438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="160" mass="18737" checksum="C733B251AA8B324A" modified="2020-06-17" version="1">MKKTNDKKEYRRAQAVLKKGEGKTHKTIAKEHVVDERTTQRWIATYIKKGIEGLQICRSSRSKSSITDEDREIILSALFNDPHLFGYLRNTWSLRSLAKCLTNELGIPISFKHLQRITKDLGVRCKRPKLELLHGEDYEERKQRIENYKQVASALKKREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI70</accession>
    <name>A0A6A8FI70_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">leuC</name>
        <name evidence="15" type="ORF">FIO04_00950</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000028">
        <property type="protein sequence ID" value="MRN68249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="14">
        <location>
            <begin position="7"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MRN68249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="474" mass="51954" checksum="1D18C4A5B3A2CCDF" modified="2020-06-17" version="1">MSETLFEKIWDSHVVGPGNESEQGPSLLYIDRHLIHEVTSPQAFAGLRAIGRTVRRPDLTFATMDHNVPTDNRSLPIVDPISSLQIHRLEQNCKDFGITLFDVNSPDQGIVHIIAPELGITLPGTTIVCGDSHTSTHGAFGTIAFGIGTSEVEHVLATQCLWMDKPKTFAINIVGSPRNPRAVTAKDVILSLIRQIGTSGATSTVIEYRGETISKFSMEERMTICNMSIEAGARAGLIAPDRTTFEYIRGRRYAPQGEQFEKMVEFWEENLTTDPNAQFDESFILNVDHLAPQVSWGTNPSMVVDVTETIPFPADFAKGSENERKAAFRALDYMALEPGTPIVEIPIDRVFIGSCTNSRLGDLLEASIIAKGRKVSPNVRAMVVPGSQQVKREAERLGLDKIFKAAGFEWRESGCSMCLGMNPDILAPGERCASTSNRNFEGRQGTGGRTHLVSPVMAAAAAIEGHFVDIRDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIA5</accession>
    <name>A0A6A8FIA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000083">
        <property type="protein sequence ID" value="MRN68512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="193" mass="21489" checksum="A3DB76890D8528D9" modified="2020-06-17" version="1">MPKRKVKEEKAPKRLGKKEVLIPPIAMGASLLVALVILPHFAPPPIPTKICLRSQNADQFNLYPRVQVFVDSKQNSLPAGVGNSTVNGKECLHVIHTDAAGSTIHIEYIRPIRLTMADFMKIYSPDNKTISVVENSSGIPHIKTLSLENYNIHYSYYSEKGEFTKVNKPSDFPPFVNNMVARLELTSTSQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FID6</accession>
    <name>A0A6A8FID6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000092">
        <property type="protein sequence ID" value="MRN68542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="241" mass="25990" checksum="11E7CCC323E781E2" modified="2020-06-17" version="1">MVRESMNNKLVLLTGALAIAMVTGILLVVVSARILGPEFVSGKLISARLLTNANTLNNLTTGNVVKVKTGGGDSNVSSTQFFPQTVEIKTGGSVTWYNPTRVPEPHTVTFQMGSLYPTQSFLPVEVSKSAQLTLLPSAASNGEPIVVPGQNHTSFIIAANARAYNPVVINSNGSMTFLNWDAKYTMNGSEKYINSGWLFPNGEIPPGIQAGRTFTITFEKAGLYEYTCVFHPWMTGKVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIF5</accession>
    <name>A0A6A8FIF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000043">
        <property type="protein sequence ID" value="MRN68329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="138" mass="15799" checksum="029C65622256D81A" modified="2020-06-17" version="1">MSNIEIDDQTWLLLRLEYQVLKSIKVNSKTEKKIARQLGVNVSIISQVITGLMLKGFVERTRERRMLFYSEYFSTTMDGLLALEANSATIMHPWSRVLLLCRDIANRMLIPLASQSLAVRLGIGAVKTTYRLAKFTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIG0</accession>
    <name>A0A6A8FIG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO03_10125</name>
        <name evidence="9" type="ORF">FIO04_02565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000578">
        <property type="protein sequence ID" value="MRN62379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000097">
        <property type="protein sequence ID" value="MRN68562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN62379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="115" mass="13007" checksum="D7B4B0B09EF59B96" modified="2020-06-17" version="1">MRERQIMRIHYITGLAALFVVAVHILMRLIMPFHMSLQYSNVIANYHNLPYVILLESILVLLAIHGFNGLRIILLELRQNRKWENGVTISTIAAMIAIIAFGTRTIIIANGLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIH7</accession>
    <name>A0A6A8FIH7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_01020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000030">
        <property type="protein sequence ID" value="MRN68263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="213" mass="23588" checksum="B34B50744E64094C" modified="2020-06-17" version="1">MFNLAILISGRGSNMEAILSAIKQGKIKNIRPSIVISDKAAAAGLKIASEKFCVPTNTLPSYGSRGWKYDQKLVQILEEYGVNKSAGVICLAGFMRVLSREVVRKYKMRIMNIHPALLPSFPGLRAQKQALDYGVKVSGCTVHFVDEGIDTGPILLQRTVPVFESDTEEQLAERILQVEHELYPEALGLFSKGNIRIDGRKVSILHCSREDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FII8</accession>
    <name>A0A6A8FII8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroE</name>
        <name evidence="8" type="ORF">FIO04_01075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000032">
        <property type="protein sequence ID" value="MRN68273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="5">
        <location>
            <begin position="61"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="7">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="24457" checksum="57BFA8E180CFC472" modified="2020-06-17" version="1" fragment="single">TNISGFNVTIPHKVGIIPYIDELDPSAKKSNAVNTVHCIEGTFKGYNTDVQGFIEPLHKRRVSFNGMKILLIGSGGAARAIIAALSNEIGISHIIIANRTKKNADELITMASNLGLSANFTRIEYLGEHALKSDLIINSTPSGMNDEQSIVDYEHISKDSIVYDIVYSPMVTNLIEQAKNAKATVIYGYEMLLAQGSKAFEIWTGITAPVEAMKKALFGPFGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK3</accession>
    <name>A0A6A8FIK3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ammonia monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000118">
        <property type="protein sequence ID" value="MRN68628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023301">
        <property type="entry name" value="NH3_CH4_mOase_suB_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="63" mass="6652" checksum="00D37C20A8DEEBD1" modified="2020-06-17" version="1" fragment="single">AIYHVHTQLNIEHIGPGLGPGQTVQVTGPAILKPVPWGNVAYQVVLIGAGLGVTFATRPWQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK7</accession>
    <name>A0A6A8FIK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000172">
        <property type="protein sequence ID" value="MRN68796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="252" mass="27779" checksum="53C60778FE33EE60" modified="2020-06-17" version="1">MDASVLIPIGAEPHNFDPTIQEIQKANSANLLVFNGASMEEPWIHNLTPQNAIDTSKGINLLANPNDPDIKGPNDPHIWLDPVLAIQQVQNIRNGLEKVDPKNTAYYNQNAQNFIGKLNKVDTAFRGNLSSSNCPKRDFIPFHLAFGYFAPHYGLTQHPIHEGLTPSGEVLPQKLVEVVNLAKNLGLKVIYNEDLIDPRSAQAIAEQIPGAKVMVLSPIERINATEQKAGIGYLDKMYQDLAAFKVGLQCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM3</accession>
    <name>A0A6A8FIM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO03_02140</name>
        <name evidence="5" type="ORF">FIO04_00120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000048">
        <property type="protein sequence ID" value="MRN60845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="24"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN60845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="298" mass="33268" checksum="C0B39AD9A9ED7A6F" modified="2020-06-17" version="1">MLTVFGTIALDTTRTPFKTETMILGGAATFASLSSSMFTNTSIVGIVGSDFPAEYRTIIDKRVDTRGIVTENGGKTFHYDSSFDYDLSRRTSNKTELNVIAQFEPVIPDEYIKSEYIYLANNDPRQNIKILEYFSDPKLVVCDTIEYWILNCHANVVKMMSAVDGVVINDDEARLLCKNTNLVKCAKTIISWGPQFVIIKKGEHGSLLIAENIVFPAPAYPLEEIVDPTGAGDSFAGGFIGYIAKQNSLTFNTMKEAVVYGNVMGSFAVEDFGIRRLLSVTQDDVQMRYRDYRNLVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN2</accession>
    <name>A0A6A8FIN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-guided pseudouridylation complex pseudouridine synthase subunit Cbf5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000298">
        <property type="protein sequence ID" value="MRN69101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DKCLD" evidence="1">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="70" mass="7734" checksum="E5CD9CE69C51D8C2" modified="2020-06-17" version="1" fragment="single">MPQLQNLMKVDDDVTDEAYGHYPDRRPVSSLLDYGLILIDKPAGPSSHEIVAWIKKILCIQSAGHSGTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ7</accession>
    <name>A0A6A8FIQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000187">
        <property type="protein sequence ID" value="MRN68846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="480" mass="54255" checksum="C4BBC00F4561D299" modified="2020-06-17" version="1">MIPVTVAKFGGSALGVDGIFIGKIINRIEQLKEKTKVVAVFSAPLITYQEKPYSMTDVAIRVGRSYASSNPIEIEVLREVYERIASEQVSNQYYQEFLAHLDRFYRQVIISLKQAAENRRFVDVIRSRTLAYSGEITMSYLMDYIMRSHGINSDHVDIEKWPIITDDNFEAANFMIEESRRNDSHLLDLVERNEIVCLGGFIGKTVDGLETTYERGGSDRTAADTAILLHGRYEMKVDFEKDSAVLSADPKIVKSGLENIQCLSYNEAKLAGMFGMKILDPVAIKEILDNNLDIPLVITNMTNPSDTTMIQRNPPLQDDFNNSLVKIVTGKKNCAIVRIESIAASYLIASLEKDKQYHDFVKLSPYRQDDLEICRLLFLDADYVKKQERHFKAYYPKVEIVYGRGVVTLIGDMMWHMPNIASTASSTVGEHGINILNLDAQEETSRILIVVEDKGTNVSEAVKAIHSKRTNIRISENKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS7</accession>
    <name>A0A6A8FIS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000321">
        <property type="protein sequence ID" value="MRN69151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="130" mass="14532" checksum="181F69643B88B8CF" modified="2020-06-17" version="1">MVTRVNLTRTPLLSIKLMGDVIEQRMDGIIISTPTGSTGHSFSIGGPVLYERLESLLLSPIAPMNKMPRLVLPPDEIEVKSTHDLSLVVDGQEIFPIAAGEPLKISRHQYDARFIRIRKRGMRQIVKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIU6</accession>
    <name>A0A6A8FIU6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000072">
        <property type="protein sequence ID" value="MRN68469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="98" mass="11505" checksum="1879F02E7B252D8A" modified="2020-06-17" version="1">MSNICLGDASRCLIGGELNKITSMILFIPERKQCEYCHEKFNKLDDIIEHLKNVHHQSVPKCHNCGKEFLHEKDRLHHVREENERKADARRHSKTGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW3</accession>
    <name>A0A6A8FIW3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_11630</name>
        <name evidence="3" type="ORF">FIO04_02195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000360">
        <property type="protein sequence ID" value="MRN41674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000078">
        <property type="protein sequence ID" value="MRN68489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="240" mass="26698" checksum="DFC5FA3A17D54D18" modified="2020-06-17" version="1">MSFTNVSVLEQIRARVAKTLTAGIQLNMSTDESKKLLKRHVNRKTNVVIMFTDVNNSTEMSLSLPEDRFALMIQTFAQEISIAVTGYGGYVFKYEGDAVIGLFPGEYDQAKACKNALNCTTSILEIIKEVINPAFKENGLPEISVRIGLTYGYALVVLYGNSLEKAYIDIIGSSISLASKIVSIAKANQVLVGESIYNILLSSESISDSKFIEINLDPTKWKYLSRSDPESMYRVYEYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW8</accession>
    <name>A0A6A8FIW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000192">
        <property type="protein sequence ID" value="MRN68856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="214"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="337" mass="34722" checksum="7ED4DD5379DD90EF" modified="2020-06-17" version="1">MENSVVQITARTPNPNLQIITNGNPSTGQSTRLGSGFVYGKQGHIITNSHVIDGASTADITFIDGNTYTAKVIGKDTSGDIAVLQIIDNFSPENLVPLTIANSSSLQVGQQVIAIGNPFGLSDTMTTGIVSQTGRLIPNPDTGFSIPGGIQTDAPINPGNSGGPLLNTQGQVIGINTAINSATGAFSGIGFAVPSNAIIRELATLTKTGTFNHPWLGIAGGKITPDLGQSAGLPRNYKGVVVGSVQAGSPAEKAGLQGVTQSDSTTTQHIGDIITGADGHPLRSIDDLINYIDLHKSIGDNVGLTVNRHGQIMNLNLVLQARPPSLGNQTAQESILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX9</accession>
    <name>A0A6A8FIX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000061">
        <property type="protein sequence ID" value="MRN68423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="804" mass="89718" checksum="DCB61976E0C548DA" modified="2020-06-17" version="1">MRTMLLWSIAVIGLLLFGVFLNIGVYAQSPKKSAYVDTVRFIQYLDDNVALQEIKSGNLDTYFFRIPLETVSDVKADPNLKVYDRIAGSFGLLLNPAPSKDDNSINPFQFRQVRFAMNYLVDREFVVDEILRGYGTPLAAPFGVYSPEYLNVLDTIESFGFRYNPQFAQKLISDTLTKAGATNQGGKWFFKGSPIKVKILIRSDDPQRLSMGELVASELQSAGFNVQTDFGDLNKANPIVYGSNPQDFLWQVYTEAFAGTSAFVKYNPIVASQMYAPYYGNMPGAQNPAFWNYRNETLDKLTQRIEFFNFTSEGQRNELLRNATRDGIDESVRIFITQNTEPFVASSTIKGLINDFGAGITSKLSLMNARTPKSSNTLDIGVKQIYQGAWNNVAGCKDAYCTQIYSAISDSATFRNPYTGEVIPMREHWIDVSTKGPTGKLKVPPDAQIWDPYSQHWKSVGQNASSMSEVTYKILYSNWHNGISMDKSDLLYTQYFLFQWGTNTGKGDLTIDPEFTSQAQAALPLIKGLRFIANDEMESYINMWHYDKKEIADAATIWPAEPWEITAATERLVTSGKLAYSSGEATAKNVDWLSLLIPAHAEMIKEELQKMKDEGYVPAALKGIVSVDNATKRYDASINWITNHKNAVIGNGPFYLDSYNPAGGIIIIKAFRDPSYPFSQGYWSSFENPKLATLQSINAPQFISIGQQPVVVSLTVNVGGKPSNDTIVNYFISNKDDKVVVQGVAKPASADNKLGTYNIILRENDTSKLSVGPNTLKIFANSKEAFKPDIYSTVLIENFSRFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ0</accession>
    <name>A0A6A8FIZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_09400</name>
        <name evidence="2" type="ORF">FIO04_03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000226">
        <property type="protein sequence ID" value="MRN41243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000166">
        <property type="protein sequence ID" value="MRN68778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="163" mass="18768" checksum="E4BF725581C2CCFF" modified="2020-06-17" version="1">MSRIHQFSKLDLKFGGFKVGQTFKSRIVIDKDDFQKYISFAKTRNILHEKPELAAKEGIKGTLLPGRAIIARAEGEMTRLDIFSGSIMLLYGMDGDPNWDNRHTRFLDEVYAGDELEVEYSISDKKEGNSECYGILSIDVQIRRISDNKLVIVSRRNLYRMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ5</accession>
    <name>A0A6A8FIZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000203">
        <property type="protein sequence ID" value="MRN68886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="3">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="291" mass="32137" checksum="167DDDAD6624BF08" modified="2020-06-17" version="1">MSRFRSLLFVPGINPRFVDKAKKLNADIICFDLEDSVLPSEKVTARKLLVQALKQRANYNLTENVYVRINSPESGISGKDLTSTIQKGLDGIVVPKVSEESEIVELCSLITELEQKRRIEKNRIKLMPSIETAKGVVNAHSIAKADLRVNALIFGLYDFLHDMHLDHADNDGTGYSYARWKIPVDARAAGVVAIDAIWQKVDDIPGLRNDAASAKRLGYVGKSIIHPNHIEPVHEIFKPSKIEIGWATKVVNALGPAMRKGKGGGVVKLEGKMIDAAHYKQAKAILDIVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ8</accession>
    <name>A0A6A8FIZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000069">
        <property type="protein sequence ID" value="MRN68453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="198" mass="21456" checksum="68419DE86360853F" modified="2020-06-17" version="1">MPGKHGLPTLNGNQNNTYSNKRQKIVSLNSYKDAKTIYKFMSGKTAILTLMVMLIAVVLSSPIAHAAVTPTCDKSLWQHVFLPTRLHIVNPCITATGVIKSIQVVNDGDFHIKLLADNSSLINQANIKFENGDLVLEAICQNTVSRSEVGSACDNFNHPALSIPPVGSHVTVTGSYVLDTRNNNWAEIHPITSIAAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ28</accession>
    <name>A0A6A8FJ28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_06180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000384">
        <property type="protein sequence ID" value="MRN69274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="154"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="300" mass="32136" checksum="28ED0AB4A2F5A8A2" modified="2020-06-17" version="1" fragment="single">MEDRNGRLFGTNGVRGVFGSELTLDLIVDLSYSLATYYENGPIIVGCDGRESSPIISRIVRSTINSAGVDVRNAGLLPTPCLQYAVKFLDYNGGIMITASHNPAEYNGIKPIAADGVEISREDELDVEAIYYSKRFSKIDGYGLDFPDPLVINSYLNDVTQLIDIETIRKRRFTIALDAGNGVQATVAPLLAERLGCKIVALNSTIDGTFPTRGSEPTLDNLQVLSSIVRGTKADLGVAYDGDGDRSIFCDEKGVVQPGDRTGATIVSHLLTTKHKGADVVCPINSTMAVSIVANEAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ43</accession>
    <name>A0A6A8FJ43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_01480</name>
        <name evidence="6" type="ORF">FIO03_04330</name>
        <name evidence="7" type="ORF">FIO04_03970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000012">
        <property type="protein sequence ID" value="MRN39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000127">
        <property type="protein sequence ID" value="MRN61268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000184">
        <property type="protein sequence ID" value="MRN68838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="102" mass="10955" checksum="5109198A4B5D494E" modified="2020-06-17" version="1">MAKVVVGKTSDIPEGKLTHVTAGGKEVLVANVGGNYYAMGDTCNHAGAELHEGELNGKELTCPWHGAKWDVTNGNLLWFPAKLNPEESFKVSIENGTVYLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ50</accession>
    <name>A0A6A8FJ50_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000180">
        <property type="protein sequence ID" value="MRN68822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="92" mass="10480" checksum="203C46C902A2E14C" modified="2020-06-17" version="1">MNYRDKTDISATILEVANGGASKSKIISIAFLNHSSSLQYFRMLLKNNLLVYQKEKRMFKTTPTGIQFLQLYHLMNELVNENNNLSSIHGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ54</accession>
    <name>A0A6A8FJ54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000188">
        <property type="protein sequence ID" value="MRN68848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="234" mass="26136" checksum="8705A7FD2F29C3C6" modified="2020-06-17" version="1">MNNIEKKRNNTNAITISRTFYYDLTHLITQEMPVYPGDPQPEFKPIATIEKQKVNVTRIVIGSHTGTHVDAQKHFIANGNSIDKEPLDKFMGEAVTLDISNINIGDGITGSDLENYSKVVKHKDILLLYTGTSDKWTKDDSIRNNFTYLEPSAADWIVDHKIKCVGIDTLSMEKYGFKEGLTHKKLLSNGIGIIENLNSNLKKIISMRTFLICMPLPLEGVDGTPARAVAFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ78</accession>
    <name>A0A6A8FJ78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ku protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000396">
        <property type="protein sequence ID" value="MRN69291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="2">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="265" mass="30290" checksum="39B7D0057415CB9A" modified="2020-06-17" version="1">MASRSMWRGSVSFGLVNIPVKVYLATEDREFSFNQLCPNGHRIQYKKWCPIEDKEVSYSEIKKGYEVTKDNYVVVEKGDLDKIKLKTTNTIDIREFIQDKELDPILIEKSYYVAPDNKSGNDKAYSLFVKVLSEAKKIAIGKVVFKDKEHIVALRPYQRGILMHMLHYIDEIRPVDEISELKGIQRANVDTKELSLGKLLVENLSSEHFDVSQYSDAYAKELEKLIDSKVKGKTVIAKPAERLKEDTRDLVAALKASLQKSKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ80</accession>
    <name>A0A6A8FJ80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000106">
        <property type="protein sequence ID" value="MRN68589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="325" mass="36518" checksum="05D382E5C1410D6D" modified="2020-06-17" version="1">MKVIIFSHESDLDGLFSAAIGLIRYPQARLVFLNYGAESFIKMRGFVESATRSSQEKGIVVISDLGLGSDPSLINTCRETFSIAKKKNWSIIWIDHHPWPENAIQGIEPFVELVLDSVSSKCAAELICERLLSGHRLAEKLASLAHTMDYFTNDQYLTPTSELIKYYHNFPDCYTRLINLAQKSSHGILWDIEMQTDYNEYALLRDEAKERVLSTMRIRDIHNIKIAFIQSSPFIQNSLFSDEVFKKTGVDLAMVYGTDGRVSIRRNNNKISCNDIAANLPEGGGHIFAAGAIFRSNPSDIESVILELERAVLTTLESTDTDANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ81</accession>
    <name>A0A6A8FJ81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000239">
        <property type="protein sequence ID" value="MRN68976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REPA_OB_2" evidence="2">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="164" mass="18385" checksum="4096B62E1E804F1D" modified="2020-06-17" version="1" fragment="single">MSADFKTMIESLLSQKPEISLEQVRELIDEKKRKIGAGYLTDQGALFLVAADLGVSLGNVKRANGAIKDLFVGAKDVSVVGRIMNIYPTRKFLRKDTKEEIRNRTLTIYDHESAVRVKLWDDQISLPDEARFRPGELVKISRGYVKSGFDGRPVINLSSSSQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ88</accession>
    <name>A0A6A8FJ88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000420">
        <property type="protein sequence ID" value="MRN69334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog_N" evidence="2">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="94" mass="10604" checksum="50EB302D79DEF754" modified="2020-06-17" version="1" fragment="single">MSDSRNVSTINPFEVALEQLDEAAKLIKLDNGLHQILAHPKRVLIVSIPVRLDNNEIRVFTGFRSQHNDARGPYKGGIRYHPQVTIDEVKALSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA1</accession>
    <name>A0A6A8FJA1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_02520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000095">
        <property type="protein sequence ID" value="MRN68553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="257" mass="29901" checksum="26DFE0493D8D2380" modified="2020-06-17" version="1">MTEIDSGSIHLVVTSPPYWNLKKYGQERLGPNQSYAKYLYEIQLVLKEVKRVMAPGRFVAINVGTAVSNNGMKPINGDIMRLMEDLNFTFKKEIIWIKPKGTQGLWQRGVTKFLKNEPYPCFFSLNIMHEYILIFENEGQMQICLKPEHRLPEDFIKKVSWSVWDMGVSYTKGHPAPFPDELPYRLIKLYTLPEETVLDPFGGSGTTMKVARNLNRNSIVYEINTEYIELIKQNVKWEETLDLDSKYEIKIRKPITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA4</accession>
    <name>A0A6A8FJA4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000207">
        <property type="protein sequence ID" value="MRN68898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="107" mass="12362" checksum="865EFE6F8DBB0A8A" modified="2020-06-17" version="1">MLAKVSMNNQEAPTTQQHIRNRSRLDVIAAILREVTGREATKTRIMYGAFLSSTQMREYVPFLLNNGLLTKVEQSIYKITEKGTRFLMLCDQLNNMIGDKGKYRVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB7</accession>
    <name>A0A6A8FJB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF192 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000119">
        <property type="protein sequence ID" value="MRN68629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="163" mass="18236" checksum="9993BD6B534797C2" modified="2020-06-17" version="1">MVHKIAVLIPVMVAATALGVLGLVFIPPGVKNAPAGFPVGTVRINHDVINVEVAKSSAEKERWLMFRHEKMPFNSAMILVYDKPDLYSMWLLNIGYNLDLIWFDENGNVVYMVKDVPPCKSTFDMADCTYKNTEPAKYVIAATSGFIDKHRVNKDSRMSITSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC0</accession>
    <name>A0A6A8FJC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">50S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO02_11775</name>
        <name evidence="8" type="ORF">FIO04_01195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000370">
        <property type="protein sequence ID" value="MRN41702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="6">
        <location>
            <begin position="56"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN41702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="164" mass="18125" checksum="DEA5B0F812388960" modified="2020-06-17" version="1">MTRIIVGKVVVNIGVGKSGEPLEKAKRGLEELTGQRPTVRGAKNSVRDFGIHKGEPIAAMVTLRRDAALQFLQRTMAAKRNSLKASSFDNFGNLSMGIHEHIDLPDTKYNPDIGIFGMDVSIALTRPGYTIAKKRVHRNIGKGHRITKDDAIQFFQKQFGAEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE0</accession>
    <name>A0A6A8FJE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000461">
        <property type="protein sequence ID" value="MRN69394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="269" mass="29519" checksum="C552743A274D3745" modified="2020-06-17" version="1" fragment="single">MLDSKKKFREMDRSERLNYLRKEADLSERDIDTITDPNAAFSFDNANQMIENAIGIFSLPLGIATKFVINGKEYLIPMVIEEPSVIAAASNAAKIASQRGGFTATNVDEALMIGQVQLVSIPPLLAGSTIKKILDHKSELLSLANSNSRSVIARELQIKEIEDKSQNMMGKMLIVELLVDTKDAMGANAINTMCEAISPRLEVLTGGNVVVRILSNYSTGRLVRCKAIFARDDLGGEAIVDRILYAYAFAYSDPYRAVTHNKGIMNGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF2</accession>
    <name>A0A6A8FJF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000229">
        <property type="protein sequence ID" value="MRN68948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="283" mass="31276" checksum="E80F1BDF8CD15124" modified="2020-06-17" version="1">MIKSIIITGASSGIGKATVIRLVESGYQVFGLARRYDKLVAISSKLLTSSREDKGDNYIPMEFDITKPERFGSIINDILSKAKGGTIYGLVNNAGYVEPGAIEDITVQDLRNQFETNFFGLLEFTKKVLPFMLENNQGRIVNISSVSGLISLPLIGAYSATKYAVEAITDALRMELWNTNIKVVTVNPGLVETNINTISKPKIDNLIANKSRFSEIYRKYLYNVPKGLPPGSVATAILEAISSQTPKTRYIVGSTKVRIGVRMKKFVPDTIFFSQVAKRIHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF3</accession>
    <name>A0A6A8FJF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatininase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000222">
        <property type="protein sequence ID" value="MRN68932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="235" mass="26061" checksum="5C1F61F0677ABB44" modified="2020-06-17" version="1" fragment="single">MSVPIYNISHYEFRKCLKRTRRAIVPVGSLEQHGAHLPVSTDCLISERVATRVADAVKCFVLPVISYGVSFEHLPMFNVSLRNSTLSDMLCEVCVSLSSQGITEIIFINGHHGNIGVLQYISQNLDAKIRTKSSIFAINYWSGMHKELDHAGEVETSLVLAISPQLVRMDKAEPNFRRLSKSRIAYSTITTTPGSFPQVTGNGVWGDPRNASKEKGDRLLKEIVGNLVHIISELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF8</accession>
    <name>A0A6A8FJF8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ORF">FIO04_05080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000277">
        <property type="protein sequence ID" value="MRN69056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN69056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="479" mass="52408" checksum="D44B422F0EFAA47C" modified="2020-06-17" version="1">MVHENCGVVGAFSLNGSNVIPFVIDSLRALQHRGQESWGLAVPNKMPLKKLGLVSAAAAEFQTLVKRYKSHAAIGHVRYSTFGKSTLQNAQPLKVKDLCVAHNGTIANVEELSSMVGGCTFTPQTMSDTLVAAQRLVMHTTENGNFTEAVSILRDEMIGSFCFTFLTDSGCVYAARDPKGFRPLVMGYHKETNTYVVASESCAFSAIGAQLKRDVEPGEIMKMSLAGIESEQFSVDLPHSHCAFEYTYFAHPSSIMEGVNVYAARRRIGKFLAKQFPVHDADVVIPVPDSARPAALGYALEIGKPFEEGLLKDRYSRRGSMRSFIEPDQESRIEINKGIIPIREVIDGKNIVVVDDSIVRGNSSMSIIRTLRAAGAKRINMIITYPPISYPCYAGIDFPSQEELLAFRHASNDMSSTEAANNISKIIGADYVAYNSTTNLAKAIGIPKEELCFTCSTGDYSALGIKPIFKSRKQMKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJI3</accession>
    <name>A0A6A8FJI3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thpR</name>
        <name evidence="3" type="ORF">FIO04_02925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000120">
        <property type="protein sequence ID" value="MRN68633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="Kinase-A_anchor_nucl_local_sig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AKAP7_NLS" evidence="2">
        <location>
            <begin position="42"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="190" mass="21440" checksum="AEA54BEA0D09DA5E" modified="2020-06-17" version="1">MGNLNNIRAFIAVDVSNTLAIEKLQHELVADGGWTPEQIRPVKNQNLHFTLIFLGNIRLEIIDEIKIKISEIQFEPIKITFTGIGGFPHPNFARVIWVGVDENGNQRLVSLAEQVVIKLSEIGFTPDKPFTPHLTVFRVIGASLKIRTEILDKYGKKDFTSDIIDKVHLKRSDLTPSGPIYTNIYTVHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ0</accession>
    <name>A0A6A8FJJ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">GTP cyclohydrolase III</fullName>
            <ecNumber evidence="1 2">3.5.4.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gch3</name>
        <name evidence="4" type="ORF">FIO02_00900</name>
        <name evidence="5" type="ORF">FIO04_02975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:22468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57258"/>
            <dbReference type="EC" id="3.5.4.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the archaeal-type GTP cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.29" evidence="1 2"/>
    <dbReference type="EMBL" id="WJXE01000006">
        <property type="protein sequence ID" value="MRN39593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000122">
        <property type="protein sequence ID" value="MRN68643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043740">
        <property type="term" value="F:GTP cyclohydrolase IIa activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00608">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007839">
        <property type="entry name" value="GTP_CycHdrlase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42202">
        <property type="entry name" value="PTHR42202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05165">
        <property type="entry name" value="GCH_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009265">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="136"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="259" mass="29096" checksum="14CE14AC589EA506" modified="2020-06-17" version="1">MQLTIIRIEEYGPWTITLGSDREARLQMLQANFYYDLQRLFSAKDCLVYLNRFDEYFAITNGLSVADHLVIESELSSLYKKLKLSMAIGNGETPYQANLDAYHTRKMGELGTKKTRIFASAAVPFSMSNSIPRVNEFVQIMHIDMNNSADIGSKLSPYEMTCLIIKIYARLSEEFVKKESLTFFLGGDNFMVVSNAATKQDAEETIMKVTQGTNIKLNCGIGIGRTGRKAANAATKALDTIRDLRHVGKDLPVYEVECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ4</accession>
    <name>A0A6A8FJJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000466">
        <property type="protein sequence ID" value="MRN69401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="425" mass="46896" checksum="95CA3D8E9D6021BE" modified="2020-06-17" version="1" fragment="single">VTTTSQGKEYATTTTTITTTSTPQYHYANNFTVVILVWLLIHLVFGTVLGGVSSCISIRFGSRYRCAKCDISFSRIDSLQKHIQLVHGTTPIQLKRVLILGGGFGGIEVLRQLQKAFQDDVSIDITLVSRDNFFLFTPMLPEVSSGMIETRHILTPVRTFCNRAKFYEADVDAIDLKNKHVVIAHAIGKQTRSHTLKYDYLVLALGGKTNFFGMTEVANNALTIKSIGDAIVLRNHIISMLEQADIEHEDIELRRSLMTFVIVGGGFSGVEVAGELNDFVRESIEHFYHNLDRIDARVILVNSGDRILPEVTDDLAQFALQQLKKNGVEVMLNTRLIGATQDSVKLNNGSLISCNTLIWAGGALPDDKLIGNLLCDHDKSGRIVANKYLEINGYENSAFVVGDCACVTDPHTGSPYPPTAQHALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL7</accession>
    <name>A0A6A8FJL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000488">
        <property type="protein sequence ID" value="MRN69431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="93" mass="10150" checksum="4E0909E1C6D632FF" modified="2020-06-17" version="1" fragment="single">MFKNKQGLCILMTISVADIMKKKLETIKEMASVQQAAQKMKEKNVSSLVVVDEAGKPQGLVTERDLATKICINNVLASAVTNKEIMSSPLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN6</accession>
    <name>A0A6A8FJN6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">pfdA</name>
        <name evidence="8" type="ORF">FIO02_01465</name>
        <name evidence="9" type="ORF">FIO03_04315</name>
        <name evidence="10" type="ORF">FIO04_03515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum02</strain>
            <strain evidence="9">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000012">
        <property type="protein sequence ID" value="MRN39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000127">
        <property type="protein sequence ID" value="MRN61266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000157">
        <property type="protein sequence ID" value="MRN68749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN61266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="176" mass="19676" checksum="A5AAA1EE2A03A55E" modified="2020-06-17" version="1">MSNEINRQQAGMEQKINEMVEQSRILEAYMNDIINREATVTRLVGEARLASTAIQNIVDENVVEALTPVGIGVYVKTLVPPMKKLLINVGAGVTVEKTREDAINYVEVKIKEFELALRQLLGQKQQIAVRMEQIQAQINQMLQQGQSTPASSLSNPRKQAHDNDIRDSSRQPSHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP2</accession>
    <name>A0A6A8FJP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_02495</name>
        <name evidence="2" type="ORF">FIO04_04905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000025">
        <property type="protein sequence ID" value="MRN39897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000261">
        <property type="protein sequence ID" value="MRN69022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="76" mass="8895" checksum="0F10A1327D03EE8B" modified="2020-06-17" version="1">MQKLLQPTLNLVKINAILRYLERSRRLEIDLDGNIIWISQDKVETNRARLAEVANISKDFVDYFSTKNRATEENDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP7</accession>
    <name>A0A6A8FJP7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_01925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000065">
        <property type="protein sequence ID" value="MRN68437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="396"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="627" mass="69760" checksum="77ED1D77CB82AF6D" modified="2020-06-17" version="1">MYKTLHLKEWSASKTNIVILAAIVTVVLVVSIISYQYSTFTSNKIAEISSQEVRSNARIEVHDLSQILSNKLQTVSALLQTLTPSPLIQNDTYQKSAFILFNSRQLATSELTNFYMWLNKDGKIVWISNMNQTTYQKYKGTDLSYRPYFTLPKTTHTAYYSSLIDSNDKIPRLYISYPVFNNSTGTVDTGIDKSENTRVGGIFKGVVVAGIRADTLGNLLKNHLFSQFNSTIGLLDRNGIILYTNPQQYVGEYIFGNKFQSVLSSALNPPESKNLLNGLIKRSLQGYTGSGDILVNGKMNTIAYEPVAAGGKNFLTLYISAQQNLATNVSTLIDQQRYFTLLVVTIIAAVAIIVAFLVFSWNRRLETTVGARTAELALANEQLKVHDKMQREFINIASHEMKTPTQAILGYSKLIQRHPEKREEMIQAISRNATRLQRLTNDILDVTRIESQSLRLNLERFNLNDVISDVVEDYRSELEKSKGRVKLLHEQLNEIIYVEADKNRLSQVISNLLSNAIKFTKEGTITVKGEIKDSKALVTIKDTGQGIDPEIIPRLFSKFVAKSESGTGLGLFISKSIVEAHGGKIWAGNNHSDANGRGATFTFSLPLLRPTEGETTAGTAEGAATKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR0</accession>
    <name>A0A6A8FJR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_05010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000271">
        <property type="protein sequence ID" value="MRN69042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="121" mass="13966" checksum="282AE36B40A2A3EF" modified="2020-06-17" version="1">MPRNHILHRICSSEKIKDNTFQLFTVDDTDIVVGRRNGKLFAFNNSCPHRGASLSKGELKGDNIVCYMHGYEFNVFTGKLENMKSWKKQDTWLEQNPEWRKAGDLVLYPVSEKNGSIFVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU4</accession>
    <name>A0A6A8FJU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase</fullName>
            <ecNumber evidence="3">2.3.1.245</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lsrF</name>
        <name evidence="3" type="ORF">FIO04_01265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.245" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000039">
        <property type="protein sequence ID" value="MRN68310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="272" mass="29931" checksum="45838F7F4F93FDC9" modified="2020-06-17" version="1">MDWGMKNRMSKIIRPQDGRTVMLAVDHGYFLGPTERLENPSRTIKPLLPYADSLMLTRGVLRTSVNPSTDVPIVLRVSGGSSIVGEDLSKESITTSIEDAMKLNASCLALSIFVGSKYEHKTLTNLAKLVDEGERFGIPILAVTAVGKEMARDHRYLALACRIAAELGAHLIKTYYCENFQKVVEGCPVPVIIAGGKKLPNELDALQLAYDAVDNGAMGVDMGRNIWQSDYPVAMIKAVRAIIHENSNVKDANDKFIKEKEVEQQKEVIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJX9</accession>
    <name>A0A6A8FJX9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argF</name>
        <name evidence="9" type="ORF">FIO04_03975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="WJXC01000184">
        <property type="protein sequence ID" value="MRN68839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="157"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="320" mass="35347" checksum="37D05CD4CF397339" modified="2020-06-17" version="1">MKTLKTCLSKKDVLSLMDVNPEEIFSILRLASRFKKESRRRKSDSLLKGKVLGMIFQKPSTRTRVSFETGMYQLGGSVVYLSSSDIQLARGESIEDTARSLSLYLNCIVARLYCHVDIQRLATYASVPVINGLSDTFHPCQILADMLTIQEQKKKLEGLNVTWIGDGNNVCNDLVLGCAKTGMNIAVACPRGYEPSHQVVMLGKREGQKTGSEISITDDPAAAARNADVVVTDTFISIGRNGEKITRNKAFLPRYQVNSKLMKLAKKDAIFMHCLPATRGQEVTSDVIDGKASVVWEEAENRLHVQKALMCLLISTKKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJZ9</accession>
    <name>A0A6A8FJZ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">metG</name>
        <name evidence="11" type="ORF">FIO04_02435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000090">
        <property type="protein sequence ID" value="MRN68537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="10">
        <location>
            <begin position="12"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="424"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="334"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="559" mass="64490" checksum="3211A749203E81F7" modified="2020-06-17" version="1">MLGVNEKITSAVVTSALPYANGEIHLGHIASTYLPADIFTRYSRLTGRKIYHICASDDFGTPVLINAERENKSPSDYVAFWNRRDYEDFTTLGISFDSFSSTSSKENWQFVQYFFKRLSENGHIYEREIIQFYCKFDNKFLPDRYVIGKCPFCGAEDQYSDLCEKCGRVPDEILEPRCGICGNNPIKKQSKHYFFRLSSFSSQLKTWLNTNSNLQSDVKNYVINWINEGLRDWDITRDLSWGIPVPLPDAKGKVFYGWFDNHLCYISTLSAYLRQSGVDGKTFWNSSEIYHFIGKDIVYHHYLILPAMRMGIDEEYKLPDYIPSRGHLLLHNQKISKSRNWYIGLRDFTSTFAPDYLRFYLASITPYSQTDINFDWDVFSEKINNELIANIGNFINRALSFTQKTFSGKVPKPAEYDSDDNLSLSQIAGIAQEVGCLLSALEIDKSLKRILRFTTHFNQYFQIKQPWARKETAMTTLFIAVNAVRSIAVMLEPFIPFSCEKIWCQLGMTDSIHLQPWSSASQMRISAGHTLGKVEPIFSKIEREIIEQQKKGLGMHNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK10</accession>
    <name>A0A6A8FK10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000574">
        <property type="protein sequence ID" value="MRN69551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="60" mass="6846" checksum="056980F83901A4F7" modified="2020-06-17" version="1">MSTHTHKTVVHRFVNEFKNEGGSMTSLDNLAKMAMNSTNKPDSLEWHRICATEAVQREID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK38</accession>
    <name>A0A6A8FK38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000058">
        <property type="protein sequence ID" value="MRN68410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="47" mass="4922" checksum="578897048E2FB929" modified="2020-06-17" version="1">MKYDFTNKIVLVTGGTGALGRAITTAFIASDAIVISSYVVDSEVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK42</accession>
    <name>A0A6A8FK42_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000207">
        <property type="protein sequence ID" value="MRN68899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="87" mass="10095" checksum="8231F3D5CBED4F38" modified="2020-06-17" version="1">MKYRSRSDIVALLLDAANGGAIKTKLMYKAYLSFNQLREYLTLLVENGLIEYQEGMQTYRTTEKGIRLLQIQNTMDEIAPINYINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK44</accession>
    <name>A0A6A8FK44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_05665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000330">
        <property type="protein sequence ID" value="MRN69172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_EFTU_D2" evidence="3">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="IF-2" evidence="4">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="164" mass="17671" checksum="B22E1FDE0AB9A907" modified="2020-06-17" version="1">MATKLERHDGVARGIILEITEEIGLGPSANTIVLDGVLRQGDSIVLAKRNSAIVTKIKSLLLPKPLDEMRDPRDKFKPVTEVIAAAGVKITAPDLEGVLAGSPLYVLRRGESEERLKSIVDSEIKSAFIDTNSNGVILKCDTIGSIEAVTDLLKRENIPISEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKE4</accession>
    <name>A0A6A8FKE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000130">
        <property type="protein sequence ID" value="MRN68667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6264" checksum="2FB98FD2B929CBD7" modified="2020-06-17" version="1">MIKEKKKPIYISVGHKINLVNAIRIVKQLVKPEERIPEPLRLADIYSKALANSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKF3</accession>
    <name>A0A6A8FKF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000397">
        <property type="protein sequence ID" value="MRN69292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="246"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="366" mass="40937" checksum="4231A890A38928EF" modified="2020-06-17" version="1">MPAANESPTNYPNPSDQNSQAAETEEVSFIRSQNCCVCFVDIVESTRITSSINNPEKVRKYYGIFLNTMAAIAKNFGAKVIKNVGDCLIFYYPKTSDSSNKSSFKDVIECCITMIEARDTINEKLHEEELPSLSYRISADYGRVEVARSTTSQSDDLFGPTMNMCAKINSKASPNGLAIGDGLHKVIRSFSLLTSLEENYYHFEEMLRSEDQQEGFNKYPVFFLQHTDRSTFSQSERKQDGRHTPTILLVDDEEDILYTFKTGLASEGFNVEAFADPMEALTHFATVNSSHYDLAILDIRMPGLNGLQLYYRLKAINRNIKILFVSALDAVPELISILPDVKTTDDIIKKPVTIGNFVSAVNTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKI2</accession>
    <name>A0A6A8FKI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate ABC transporter substrate-binding protein PstS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pstS</name>
        <name evidence="4" type="ORF">FIO04_06520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000422">
        <property type="protein sequence ID" value="MRN69338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="3">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="219" mass="22713" checksum="60D874020821324E" modified="2020-06-17" version="1" fragment="single">MIVVALLSAMIISVSASQKSFAQSQVTLNGAGATFPFPLIDTWRVAYQKVHPNTNINYQSIGSGGGVKQFTAKTVDFGASDAPLTATERQAAPGAVQIPETIGSVAIAYNVPGIPTKTLKFTGPVLADIFQGKITKWNDPQIQALNPGVSLPAANIVVVHRSDGSGTTFVWTSYLSKASPSWNQTIGASKSVPWPTGIGAPGNEGVASAIKGSPNTIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKJ2</accession>
    <name>A0A6A8FKJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium transporter TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000484">
        <property type="protein sequence ID" value="MRN69426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="74" mass="8500" checksum="74C90464178625C1" modified="2020-06-17" version="1" fragment="single">NFPELRDALNTKWNVNILEPREGIGGHCLPKDTKMFLQSSKSVRSKIIIAATEVDKDYRIYRQTRAQTDTGHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKJ4</accession>
    <name>A0A6A8FKJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000274">
        <property type="protein sequence ID" value="MRN69049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="51"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="324" mass="36872" checksum="96CFDD16EAD5C358" modified="2020-06-17" version="1">MYGIHSRYSDFFSLDLTLMILFVFLLFLATINERGSSYAAPLTKVLPNFSFGAVSDWACNSNTITTVDNIASKNPRLVLGVGDYYYSDYNESRSPDCWFKIVKPIEQRLKISIGNHEHDSQSILNFYISHFNLTKQYYSFNYEAVHFVAISTELPAIGIGSEQYSFVDSDLAKASSDPRINWIIVYYHQTSYSSASLVQPLITFRDIYHPLFDKYHVDLVLQGHEHNYKRSYPIKYNISNSTNSLITDTNIHNYTNPQGRIFAIVGTAGAHLFPLFAKAPYIASQYIGHGFLDVTITNNGRIFIANFYANDGSVKDQFTINKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKN4</accession>
    <name>A0A6A8FKN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BMP family ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000454">
        <property type="protein sequence ID" value="MRN69382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="2">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="323" mass="33800" checksum="9599DAAD482E418E" modified="2020-06-17" version="1" fragment="single">GHPIQPYYSYAQPATPFKVVFVTDAKFNDGGWGAVGFNATQAMKSKYGVALTTADSIAIPDIESTLTGYADGGANLIIAQGFQWGDPVVKVAPTYPDIKFVVMTGLVNASNVASIFPMQQQGSFLLGALAAMMSKTGTIGFVGGETYPNIINIAEGYKQGARFIAPNIKVVSTYLHDFNNPAKGREAALAQINSGADFLLHVADTSGHGVIEAAAGKGVYAFGAVADQNKLAPNTVLTSFVIDMGKAYDQAYKSVKDGTFVGKLTKPGIETGKGGPGDGIVYLAPFHSLDTKVPANVKAKLAQLTQDVISGKIQVPERTTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKP7</accession>
    <name>A0A6A8FKP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000514">
        <property type="protein sequence ID" value="MRN69476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="194" mass="21866" checksum="60F4FF6AE95F6860" modified="2020-06-17" version="1">MPFNTYPKIATALENLQLYGCDGIEARIRDSLVELISTAIKFLLEIRHLKVLDQQSMIASSASSSSFSAASTPTTTTTTTTTTTTTTTSAAAIDYSKLTEEEKYILDAEKESERRRNDILLAITKGRPKVLESISKRVRSKYIVIRFLEPMEQFMGVDMKRYGPFRREDVAVLPFENARSLIENNHSMEVQSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKU9</accession>
    <name>A0A6A8FKU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000552">
        <property type="protein sequence ID" value="MRN69526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="171" mass="19578" checksum="49A32CA1856EE4CB" modified="2020-06-17" version="1">MIVNASGNMITFSELIDELKSNINYNRDVLYAISKNPNLLYKKITELASFTGSRHQVALQLHFPDPNKIKDIDSYGAENISVVIDKFRRKFAVPRENIRRKAIESLGNNIQTQDAYMYEGKEGLRIIKENGRIEILPGSIHLWCKVDQNVKNYVDWLMQNIYSPNTGGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKX5</accession>
    <name>A0A6A8FKX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000337">
        <property type="protein sequence ID" value="MRN69183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="189" mass="19304" checksum="E74886E71F79FECF" modified="2020-06-17" version="1">MYKGIAPKLGVVSVIALCGLLLESSWHSYASADLFQRNFGLLINNEISSSLPSSTISSSNGALRGLPVNNNQGVSGSGSGSIACSDGTRVEGGSISFVAFKSNVPIHGSWEVVSVRTSGASQNTGGSFQTGHIGSDQYTLTGRQISDSICRGNPPTPATISGQCGQGVTIELNADNGDKGIFTGDVTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKZ5</accession>
    <name>A0A6A8FKZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trimeric intracellular cation channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_05825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000348">
        <property type="protein sequence ID" value="MRN69203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="7">
        <location>
            <begin position="78"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="187" mass="20292" checksum="62F970313A6DBC37" modified="2020-06-17" version="1" fragment="single">AVTGAFKAIEHKADIVGVIVLSTITGVAGGVIRDIIFGIFPPTVIINPWYLIVTIVSGIVIFFLYPTLRGHWNLFLKFDAVGLGVFSIIGATIAYNLFGLNFLVMAFAGTLTAVGGGILRDVFVNEVPIVFVKELYASASFVGIVTFFVLLFIGVNVNIATIPSMLIVILIRLVSIRYNWNLPRAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL03</accession>
    <name>A0A6A8FL03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000546">
        <property type="protein sequence ID" value="MRN69518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="211" mass="22891" checksum="8A827974489F50F7" modified="2020-06-17" version="1">MQIDFCGPKGYVDVMGYDLGLTSAPIKSIMSVLHTIRNGTDIKVIHTREGHLPDLSDAPYNKVLRSKIIGNGVGIGNIPNGGLGRLLVRVEKNWDIIDDLYPIPGEYVIDKAGKGAFGQSNLPFILKNLGITHLIITGITADVCVHTVMREANDYGYWCTLLKDGTGATDYGNYQAAIKQIKMSGGVFGWVSDSNKFVKAITTAFNSSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL04</accession>
    <name>A0A6A8FL04_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000353">
        <property type="protein sequence ID" value="MRN69213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="152" mass="16168" checksum="3ADE3D10026813FD" modified="2020-06-17" version="1">MKGSPNTIGYVELNYALTTGIPYALIKNAAGNFIAPSLNSTQAAVTNSPIANSLPAADQSWTKVSLLNSPGSNTYPIATFTYLLLNKDLSTNPRLDQTKAKALVDFISWAITDGQKVAPNLGYVPLPAAIVKHDQDTLKSLTFKGTPLYTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL69</accession>
    <name>A0A6A8FL69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000384">
        <property type="protein sequence ID" value="MRN69273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="88" mass="10297" checksum="71584DFFB4C44923" modified="2020-06-17" version="1" fragment="single">MLMFNNQPGQSNSRLRIMVVDDEKDILRIIKRDLESNDLKTSFKVEAFSDGESALNAFNSHPVDYYDLVLTDIRMPKMNGFELYRHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL75</accession>
    <name>A0A6A8FL75_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOP1Ac domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000390">
        <property type="protein sequence ID" value="MRN69283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOP1Ac" evidence="2">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="404" mass="45247" checksum="EFAD06F70A29E316" modified="2020-06-17" version="1" fragment="single">SYPRTSSQKLPTSINYKKIISGLSKILFLVGSSNNESTGRSGIYITLAKSLLARDNLSPNEGSKTDPAHPAIYPTGEKPKGKLNAVEVKLFDLIIRRFLATFGDPVISGHTTVTILVKDNYVFRADGKKMLYEGWMYFYKPYHNRSDIETDLPEIHEGDILRNVVVRMDERFTQPPPRFNQASLLEEMEKEQIGTKATRSEVINTLFKRNYISSTSTHQRKNNGIGGIEATGVGFAIIQSMRKYIPSIVSTELTRSMEEQLEHIESGKAKSSLVIGYAINKIKEAVVPFKEKETEIGRQITDAVISTQNKHQQRVLGNCPMCSKGVLKIIRSSVTKKRFAGCSNYSSGGCKAIAPLPQKGSIETMDKTCDLCRWPVVKTVFAGQAKHHWEFCINMQCPSKKHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL85</accession>
    <name>A0A6A8FL85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000387">
        <property type="protein sequence ID" value="MRN69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="235" mass="26368" checksum="A6F29B1D7DFA697C" modified="2020-06-17" version="1" fragment="single">MDSQRRQLGILSHRINAFCNKVDLNCPELVPVISYPRQINDREYSGRLKELEIMGVNSILPVGNTKIGKFSILGKGGVGLVVKVESNDRKTYALKIRRIDANRRSMEREVKLHKIAISAGVGPYIYANSENFILMEFIDGCNIIGWLNHQNVNVDQVRKVVISTLEQCYSLDRANLDHGELSCLDHHVLVSESVNAHIIDFESSSIDRKTRNVTAAAHSLLLNGAVSRRVINNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL87</accession>
    <name>A0A6A8FL87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000398">
        <property type="protein sequence ID" value="MRN69293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="176" mass="19843" checksum="EE177B14B2FA8BB7" modified="2020-06-17" version="1" fragment="single">MDNNEGTELGNQNEETRKIQFTGGSSYIVSLPKKWIQDLKLKQGDLVVIARQGHSILQIAPISKRISKEQREATIEVTKDNSPYFLARKLISLYFLGFNIINISQKDGGRLSSEQREVMKDVVRRVLMGTEIIADSATSITLQVLINLLELSVDAAFKRMLLIAKSMHRDAILSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLB5</accession>
    <name>A0A6A8FLB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF763 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000236">
        <property type="protein sequence ID" value="MRN68967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="391" mass="44186" checksum="1BF248E152520E51" modified="2020-06-17" version="1">MESSTINLPLHGGHAPSYLIRRMVRLSYAISKVIVDEYGQQEFLRRLSDPLWFQAFGCVLGFDWHSSGVTTVVTGILKQALNEDVHSISIAGGKGKKARETKNDIPKLAEKHYNLSSSKIDNLLYASRMAAKIDNAALQDGYSLYHHVILFDEHGNWTVVQQGMNPNNKMARRYHWVSDYLKSFVSEPHAGIISKCKSPHTLNMTSIDSAENQKICVELARGDINNLKSSVYKIAATYTLDKRNTLDNWITADTSGKYEVSTNTTKDPSTEHYWIPRRLDWDVFRNIYDIQPQNYEQLISIPGFGPASIRALSLIGEIIFGAKASWQDPVKYNFAHGGKDGVPYPIARKIYDKSISYLTSAIEGAEIEREERIQALKKLGDLSARMFKQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLK5</accession>
    <name>A0A6A8FLK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_10050</name>
        <name evidence="6" type="ORF">FIO04_06840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000254">
        <property type="protein sequence ID" value="MRN41368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000464">
        <property type="protein sequence ID" value="MRN69399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN41368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="156" mass="17754" checksum="5677F72DB2753EC4" modified="2020-06-17" version="1">MQRFDELDMRILSELTKDASISVPQLSKKLNVNASVLYSRIKRLSKRNLIQKFTVIVNEGMLGFNVKATVGINRDPKFKDPIHSELLKIPEVRSLSEVTGRFDMIVAVNARTLEELHNVIIGLIGKIEGIQNTETFVEMQRTEKDPVYAVQQSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLP6</accession>
    <name>A0A6A8FLP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000492">
        <property type="protein sequence ID" value="MRN69439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="SSF116846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="164"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="397" mass="44212" checksum="61F9E96A7BB9E9D4" modified="2020-06-17" version="1" fragment="single">MSLAPQELENSASKYAAEAIRLDSQGSRGMAIQSYQRAIESLVKLVQVYPEYKLNKIYVERAGAYQSRIEALRMSHKLDEGSLTKPDEPTKGNRTINSNQYAKAAGRTNAQAAEPSDGALDDLVMKEKPTVHWHEVIGQEDAKRAIRESIVYPTKRADLFPLGWPRGILLYGPPGCGKTLIAAASAAEIDGYFINVDAASMMSKWLGEAEKNVSKLFVMARKLNDRENVPVLLFVDEIDSLLGTRNGEVGGEVRLKNQFLTEMDGINSKSKELLLYVIGATNKPWSLEAGFLRRFQKRIYVTLPDHSSRTNLFVQYTAALKKEPSLRSEDLAKLGEGYSASDIKDICQSAQLRVVNELFESGKAMEAKSNPRAINMTDFKEIFKIRKPSVPTDMIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM57</accession>
    <name>A0A6A8FM57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000393">
        <property type="protein sequence ID" value="MRN69287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="210" mass="23142" checksum="48179415C104723B" modified="2020-06-17" version="1">MSCKKAIEVNLGNHNDMTISKDMLQGLSPRAIPILLLLSRDLGITCYASGTGGSMGYAMVGAMVFKELSIKMPVTLVWAATDVYRGLAQAEALETLPLSKEADISNYVEILKQKNLDYKSKIDPLIAERARLIRAGGSIDSVLSNLFRLKQEQRKIRQLIKVAEKVKNATETKPSIIDYAINFGVGNTETLWRRNLLKNDSLAASIIMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM82</accession>
    <name>A0A6A8FM82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000410">
        <property type="protein sequence ID" value="MRN69317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="219" mass="22657" checksum="2DAD3DE6429C39CB" modified="2020-06-17" version="1">MKIRETTAIIGVLFGTMLVMSGVGLTNTILVNETFAATAPGNMTNATNTMNPQAVVQKGATSSSNDVKTTITNNNITLGNPFYIEYDKITSTVPGIPLNGGGHATGVTFSGNGIVKGIGFTDTGRALIIPISKTIVGIFGGLAIKANDGGGNANGNATLSFREVVHMTPAGTMQGSGAAIFNANATRNLSFLSNTVAMFTDTGNKGGTDTIKAWEWKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMN8</accession>
    <name>A0A6A8FMN8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">pcn</name>
        <name evidence="8" type="ORF">FIO04_07235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000515">
        <property type="protein sequence ID" value="MRN69477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="126"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="250" mass="27837" checksum="3CBAD5314E1C0744" modified="2020-06-17" version="1">MVFVAKTRSPDEWKVIVSAISTLVDEATFEATVEGISFRGMDPSHVALIDIHWPNSTFEGYECDDSVKFGVRVDELSKLIKRADKRDAIEVSMGENSMLHIKMYNGYKREYKIRLIESSASSTPLPKLNFNSKLVLNAVAFDKVLSDVQVVSEYILIESESKRVEFSGKGDSGEADIILESESAGLEELEVKENSKATYSLDYLTKITKAVSGAGGSIAAEYSSKMPLRLEFRMANVGRIHFYLAPRVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMQ7</accession>
    <name>A0A6A8FMQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">M24 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_07340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000529">
        <property type="protein sequence ID" value="MRN69497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="130" mass="14367" checksum="064416BD6424F075" modified="2020-06-17" version="1" fragment="single">MNFFDSYQRAGKIASEVRERARKKYHVGTTVFRICESIEAEIREMGGTPAFPVNVSLNDIAAHYTAEPNDILEVKDRDILKIDIGVQVDGYIADTAVTVCYDPKSEALVKVAEMALNEAVKVAKADTKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMZ9</accession>
    <name>A0A6A8FMZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000465">
        <property type="protein sequence ID" value="MRN69400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="182" mass="19892" checksum="B52E83F4D16723B7" modified="2020-06-17" version="1">MLNNTPNTEGSTNVNVSITVGEVKVQFNGSPDLVLTSVINFMTKQVPAIDLARKISLSYAVTELIDLFSNFIKITPEGPRVILEHEEFGMKKLSDKENVALHLVAAKIAKDLGKVSNDARQLSEIQFVTTLNPKSVSSRLSELVKAGHVLRDSTADGNESSTYKITTSGIHWLNSVLAKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNA8</accession>
    <name>A0A6A8FNA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S1 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_07305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000524">
        <property type="protein sequence ID" value="MRN69490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="75" mass="8536" checksum="99E33574A46C2123" modified="2020-06-17" version="1" fragment="single">MVTAEIRRLPDEGDVIIATIRQLTGHGAYVVLDEYNGMTGFLHISEIATGWIRNLERYVKPRQKAVLKVIRVNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFD1</accession>
    <name>A0A6A8FFD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_00605</name>
        <name evidence="2" type="ORF">FIO04_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000004">
        <property type="protein sequence ID" value="MRN39534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="134" mass="15044" checksum="8A700C0DD13F6341" modified="2020-06-17" version="1">MELSKTRQQEQDSNPREKFIMAARRHKILSNKCSRCGHLMLVTVYYCEKCFNHKFEINELEGTGKVVTYTIQAVAPEGFEDAGSYAWVVFSVDGTDFNASGFLPGVTSASDLPLGSRVRVLDYHPKHGLTLQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFQ4</accession>
    <name>A0A6A8FFQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="221" mass="23970" checksum="1441A248FB85621C" modified="2020-06-17" version="1">MSTTLTGETQLRARRTRIKILRAIADKNGSACFSEIRNATGLSTGSIYYHLERMGNYVNKDSKHYTITEEGLQMLRELDSKSSSSPTYKTNEVPFGASEAEIGRNVKQIGPVGAFIGEYSSVFVLGLVIILVPVGLFENFHIIFPNLSTAAKMIANATMISSLSIAALLSISFVVMLKRQILPSGYRGIMISASTVLAVLVVNILIFSGLGTQIGMSSFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFU0</accession>
    <name>A0A6A8FFU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="335" mass="36646" checksum="57F7A059EA85ABD2" modified="2020-06-17" version="1">MSALLKDRVWIMLSEIAKRGVYPLHASRLGVFRMPVDLTDWSDISSISNDLKSSGFKMDAYADRIYATYKWTEKGLDPLTGETLSADLNVTVEAVTGEVVDLIYQIKPLEFFGDCYWVRNYRQKADQNAKMVIDTIIRNTKIGDKLVAHYQKAEKLSLERAIKRLEELTPLAQNPKVRSAAAIPPAAGPASSPKLVQPTIAVAPKAPAAAAGADTISLSGTGTNYSKAEGPIDPEFKSKRQVVGSFQGIKVWGPVDPPGQLGIWGTQVTVDFDICIADGACIEACPVNVYEWLDTPGHPGSEKKTFMAREKDCIFCMACENVCPPQCVKIFQKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFV3</accession>
    <name>A0A6A8FFV3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="4">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">ImGP synthase subunit HisF</fullName>
            <shortName evidence="4">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hisF</name>
        <name evidence="6" type="ORF">FIO04_00310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000006">
        <property type="protein sequence ID" value="MRN68124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="267" mass="29703" checksum="D9CEE8E4D4B3F8A5" modified="2020-06-17" version="1">MPLAKRIIPCLDVDNGRVVKGIHFDRVKDAGDPVEFAQRYKLQGADELIFLDITASQQERETMKNVVRNVARVTDIPFTVGGGIRKLEDARDILLSGADKVSINTAAVKNPDLITDLMSIFGKQCVVVAIDAKRNYDDDGKNTFENHRGKKYWFEVRIYGGKVETGIDAIEWARKVESLGAGEILLTSIDADGTENGYDINLTKFICKAVRIPVIASGGCGEPRHMLEVFRKTDVDAALAASIFHYEKSTVDRVKEYLKKNGIEIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFV5</accession>
    <name>A0A6A8FFV5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantoate kinase</fullName>
            <shortName evidence="5">PoK</shortName>
            <ecNumber evidence="5">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_01135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000034">
        <property type="protein sequence ID" value="MRN68285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PTHR42282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="318" mass="34726" checksum="06E2055EFC45E41C" modified="2020-06-17" version="1">MIFIFYVPYKLNVSTVVTQPVAIAKAFSPGHITGIVKRASVPCRHFLYQGSEGAGFSIDRGVTTTVSLFDDRNSRYQISINGRTVVDADVSQLVLQQYLKFIERPYYIKIEHDIEIPIGFGLGSSGAAALSLSYALNQSLKVGLSAEQAAQIAHYAEIVCRTGLGTVIAEYTGGFETRTSAGAPGIGIIRKIELKGHRAIIFCMAPVSTKSILSDNFDFRSGWHDNTWLNNLKAAVDIREFVNMAYEFVTNMGLTSGRCKEPISSLKSHGFDSSVALFGDTIFTIVPEDRVREAEQCLVGFNGQLFTCGVDNIGARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFZ3</accession>
    <name>A0A6A8FFZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000020">
        <property type="protein sequence ID" value="MRN68201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="12553" checksum="B7258A10207AD85D" modified="2020-06-17" version="1">MTITNYALIRHEFDFSAVYVAEDSTLHQSIRSFAVKESKLLDSIGIAPMEEEIQKRVIELTKQNQDSMVEEFGIQSSLTEEDMKQYLQEVINEVQKYKTTTNKTNNGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG36</accession>
    <name>A0A6A8FG36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="132" mass="13763" checksum="3E9DBE77F815FBDF" modified="2020-06-17" version="1">MKVVGQEVLILSILMMLVISYSSAALSMKLAAASTSHSNGTQFSVVLVRSNTQNGPVNISINDTVVASNIDVTKKNSLVIPITVPDKLINGTIRICATAVTPPAAQICTDVQNTKQGGKNKVTLDLTKAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGA5</accession>
    <name>A0A6A8FGA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000065">
        <property type="protein sequence ID" value="MRN68435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="83" mass="9510" checksum="503D9BAEC69BE73A" modified="2020-06-17" version="1" fragment="single">MNNSKILLVDNEPDNTSVFKMGLEDEGFKVDAFNDPVLALSNFKPNFYSLSILDINMPKMNGYELYKEIRKLDNKVKVCFLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGE7</accession>
    <name>A0A6A8FGE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000077">
        <property type="protein sequence ID" value="MRN68485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="58"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="217" mass="24733" checksum="743F1A70F1D9B13A" modified="2020-06-17" version="1">MIVILQYIILAAADSESKKEWSDVQHALAYLNVANTLPHRTEGEAVLFEHISTDAKRILDLGTGDGRLVKLLKIGRSDMEEAIAVDASPTMLKSLREHFGNDPDVRMMEHDLNNPLSQLRADLGYFDAVVSSFAIHHLSHERKRSLYQEVYNILNPTGIFCNLEHVASPSVEHHIRFLHAIGYTPQMEDKSNKLLSIELQLKWLREIGFVDVDCYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGK0</accession>
    <name>A0A6A8FGK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000095">
        <property type="protein sequence ID" value="MRN68555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="110" mass="12235" checksum="9CFFDD1C60353285" modified="2020-06-17" version="1" fragment="single">MVQNTVQDKISPNETIEDVNKIIRDEIKKAFETVNIPAATTPPTKPEKNSILQDNDVYNDLTKGLVEDVIRALKNNNTEEAITRLTLADQQITATAGNQTSKLFIGRAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGP6</accession>
    <name>A0A6A8FGP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1743 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000057">
        <property type="protein sequence ID" value="MRN68404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1743" evidence="1">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="335" mass="37495" checksum="75F0C3DCADFD9FDC" modified="2020-06-17" version="1">MVGFDILSKQKAEKIAKANCVRHFTFGNGQGLVGSLAAIGTLEDGDHTFEAIAYRKCKNYGTTRQINATRVIQYDKRTFPNTFNNYDQNHRRVLIAPHGPDPVFCGIRGESPEVVVSSLEWLQPEEILDGYMVFRSNQGTNMHLQNELKLSGIRVYMAGYVRGKVITKPQTIQGGHVIFGIEDSGGVTGSAAVYEPTGLTKIASQMEVGDVIEIGFGVRKATCDRPPILNVEYISILKIVQICDLTNPLCKYCTKKMKSEGKNKGFQCDRCRYKDGNAKKIPVLRDRDVLTGLYVPTPKSHRHLTKPLHRYGMEKKSLGFNPRSKLIARWFFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGR5</accession>
    <name>A0A6A8FGR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_02230</name>
        <name evidence="2" type="ORF">FIO04_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000022">
        <property type="protein sequence ID" value="MRN39846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000061">
        <property type="protein sequence ID" value="MRN68424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="109" mass="12752" checksum="216190E2B511A517" modified="2020-06-17" version="1">MQTVGRIPRWVIEKDPSWEKAVHSNYDILEWTKKGADLRATCDPASMFCDVMIEERNQHLDLSDPISKFNNKSRLSTFASADIARYLSSRYLNPRFDINRTGLFKFHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGR9</accession>
    <name>A0A6A8FGR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_00170</name>
        <name evidence="4" type="ORF">FIO04_00575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000001">
        <property type="protein sequence ID" value="MRN39448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000015">
        <property type="protein sequence ID" value="MRN68176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN39448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="83" mass="9167" checksum="7E6C2F8A42DC34CE" modified="2020-06-17" version="1">MIPNGNQVLIGPARITRFEKARITGARSLQLSLGAPAFIRVPQEVRDSISLATAELYAKALPLSIRRVLPNGVYQDIPIEWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGS5</accession>
    <name>A0A6A8FGS5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_01910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000064">
        <property type="protein sequence ID" value="MRN68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="179"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="409" mass="45403" checksum="51B555A17A7A9042" modified="2020-06-17" version="1">MDIRDPKHAYSLFASEIQHAQSEVLIAVNSILYLEYLAETGLVDSLKKAQSNGVNVMILYSEEGQNEVATTSQIVSAIKNYAQIKCVSGIYETIFLIDNSKVLTINEGDDGIKAFAVYSNNKSIVKNIGSLLDSLWNEKEMLDSIIAIKDNLADTNKQLVEANEQLKIHDKMQREFIEIAAHELRTPIMPILGYAEILKAEQEQEEQEGIVGEIEKNKNKRNYIDAIIRNAKRLEQVSQLILDIASIDGKTFRLDKKRLNLADVLLNAVNDQIITIAQDLEKKNNIKLRYEPCEDNILIQADRIRLTQVISNLLGNAVKFTKKGIISITIKKENDKAIVGIQDTGLGIDAEIMSRLFSKFATKSDTGGTGLGLYISKSIIEAHGGTISAGNNEDGKRGATFTFSIPLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGS8</accession>
    <name>A0A6A8FGS8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000069">
        <property type="protein sequence ID" value="MRN68451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_1" evidence="2">
        <location>
            <begin position="79"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="213" mass="24052" checksum="4E50C8B377F6E031" modified="2020-06-17" version="1" fragment="single">AGQFAFFDIGGVSNDPKGPIRHFTIASSPTEDFIMISTRIRDTPYKKRLSSLEKGVKVKVRGPEGKFVLHEDYSKAAVLLSGGIGVTPFRSMIKYATDKQLPLKLNMFDSNRDQANILYKNEFDECLKTNKNLKIIYTITAAKEQEPSSNSWKGERGIINKTMLTKYLTTSEVDNSLFYICGPPGMLKAMQNLLQDDLHIPKERIKVEEFTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGT7</accession>
    <name>A0A6A8FGT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000070">
        <property type="protein sequence ID" value="MRN68461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="195" mass="22490" checksum="AD34661BF8C38F8C" modified="2020-06-17" version="1">MGNPLKVAEDMIELEEKGDILNSLLRIVTFLCNRYAMGASNAALIGECVYPETSFVFDEQNSSSYRKEIAHMARYFRLHLGSFLAIELAKELERFPSNYKDNRFESIIELYETGCADYIFNFLLDTKTREEKLVTPILMDLDGDRKVLAIHIYGDEKIRLWKRWGDGYDGLYDISGNRSNIHMEVSPFFDSVAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGV8</accession>
    <name>A0A6A8FGV8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_00675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000019">
        <property type="protein sequence ID" value="MRN68196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="341"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="416" mass="44813" checksum="BD9489174878757F" modified="2020-06-17" version="1">MKAGHIRGANEKHGFPTIEDIFKARDLLNKAVRKTPLQRSDTFSKLTGTNIFLKLESLQKTGSFKVRGAFVKLDMLSNEERKYGVIAASAGNHAQGVAYAALKKNISCTIVMPKNASPAKVAATKSYGAKVTLRGLDYEESWLAAQEIAKEEGRTVIHAFDDAQIISGQGTIGLELLEDLREIDEVYLPVGGGGLAAGVAIAIKAKNPNVKIVGIESKAFPAMKESLAKGSLQHVKAGYTIADGISVKSPGKLTYEIASKYLDDLRLVEDSSIVETMFLLMERAKLVVEPAGAASLAYLISNGHPNKDKNVIALLSGGNVDMYLLGQVVAKGLMHMGRMLKIFIQLPDRPGALKTIVDSIAELSVNIVEVDHDRLSPNISAGTAGVYLSLEMENANHAKRLIDFLEAKGVEFRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH67</accession>
    <name>A0A6A8FH67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000106">
        <property type="protein sequence ID" value="MRN68591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="PTHR13452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="74"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="191" mass="21859" checksum="60A674611A12CE84" modified="2020-06-17" version="1">MPGFFQQTTTDLVMDFNLIVSTYRHREDDAQNELHDILELFGDPKPGSDITDLVGILIGRTALEPFEVVKRIKELVNDEPWRVRYILRLIPIEFAFTEDGLDSIKNAAKRLASKMQKFETFRITVERRNTSLRSSEIIATVGSEIDNRVDLENPDWIVLVEIIGKLVGISVLRPNEIFSSLIEKRQGETVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHD3</accession>
    <name>A0A6A8FHD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03900</name>
        <name evidence="2" type="ORF">FIO04_02930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000110">
        <property type="protein sequence ID" value="MRN61184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000120">
        <property type="protein sequence ID" value="MRN68634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="192" mass="21444" checksum="C518D7D49568AA40" modified="2020-06-17" version="1">MPGSGKSTVAESLKKKGFSVIAMGDVVRDEAKRKNIEPTDINLGKLMLKLRREIGPGAIAQLILNEIEKREVRSDANQNIVIDGVRSVPEVEILRTIGLVKLLSIHASANTRFDHLKKRARDDAPLNENDFGIRDKRELAVGISEAIAMSDEMLSNNNLTVEELKEKAIGIVQKWVGEFYNDDWILNNKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHE8</accession>
    <name>A0A6A8FHE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000053">
        <property type="protein sequence ID" value="MRN68386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="91" mass="10064" checksum="3D71B8726CC0D601" modified="2020-06-17" version="1" fragment="single">DTQAVYRAGAALLDLKDPTKVLGRTKRPILEPLEPYEKNGDVNNVVFPTGVCTMDGTLFVYYGAADKVCCLATIDLETLLDYILHENRVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHG6</accession>
    <name>A0A6A8FHG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000129">
        <property type="protein sequence ID" value="MRN68664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="253" mass="27739" checksum="3FCC5A40034362CF" modified="2020-06-17" version="1">MKITFELNPPKILKDQRFDLVLLNQEIQKLTKRASELVDLVNGIHLTDSVLGIPRISSVTAANLIKRTGNPLNLSCSVRARDRNYTSICQFVSDAILIGVKGVLVLMGDDPVGGSIDLGLKPSSVLKMLNYEKYNSVIDFYLTIPAKIKSSASIQKKINAKPSAFVTQSIASLAELGEIVDVARSHNIPVVACIMVPSNNNQMSAETIGLDWKEYQNNAVDFIKEAGDLANEVLLTSPNSFRSGVELLERLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHG8</accession>
    <name>A0A6A8FHG8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO03_06115</name>
        <name evidence="4" type="ORF">FIO04_00965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000219">
        <property type="protein sequence ID" value="MRN61610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000029">
        <property type="protein sequence ID" value="MRN68252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NikR_C" evidence="2">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="149" mass="17018" checksum="83CBCD8545483A28" modified="2020-06-17" version="1">MTLKQANGHEHDEKTYVHRISMSLSPKLLAEFDKSMIKAGFTDRSKAIQTALHSFVDEHNWVDDLPKSGAGAIIMLYDNHVYNQDTKSTRIQHKYNDIISAATHLHLNDNNCLESIMVKGDVRRMKELANELSKNRGIKSLKFHFVNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHJ5</accession>
    <name>A0A6A8FHJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000065">
        <property type="protein sequence ID" value="MRN68436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="117" mass="13615" checksum="A7F4EA46A1A2D0B8" modified="2020-06-17" version="1">MVFSMALEDNGFKVDVFNDPLLALSEFKKGSYDLILLDYKMPNMNGFELYTEIIKIDDKVKVCFITAYEIYYEELKKRFQSSFSMPSAYGKENVKCFISKPIEIDDFVNKVKEEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHK4</accession>
    <name>A0A6A8FHK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_03230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000138">
        <property type="protein sequence ID" value="MRN68694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="82"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="181" mass="20315" checksum="FCD8A20C083F12D2" modified="2020-06-17" version="1">MSRDWRNQWLGQSIFEDIDREFAEAEDMLSRMFKTVRDNGPSATASVANSPYYYGYQITIRSDGKPEIREFGNVKSTARGLVEQSGVRQPLADTVLDEKQNTLRITAEMPGVNKEDIKISVNDGYVTIQAEKGDKKYDANIPVSVNLEESSAKAAYSNGILDLKIKLKETSKTKVKQIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHL1</accession>
    <name>A0A6A8FHL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000141">
        <property type="protein sequence ID" value="MRN68704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="95" mass="10788" checksum="0E0B0FF12D910D4C" modified="2020-06-17" version="1">MSASTDVISFLYVDVLEYSEEKTFVAECLEIPVIVEAETLDKVESKMKLAIEGFFETFTEERTAVLNKRRIPVPNRPEVIPSGNRTVLKMVMPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHP1</accession>
    <name>A0A6A8FHP1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_01330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000042">
        <property type="protein sequence ID" value="MRN68322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="7">
        <location>
            <begin position="145"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="304" mass="32527" checksum="71BB310A386C7694" modified="2020-06-17" version="1">MTISIIGSGKVGASIALNCAIRDLDDVLLVDIVQGLPQGEAMDINHQLSEMGIDRLVRGSNNYADINDSGIVVLVAGLGRKPGMSRMDLLHTNANIVKDVSMKVASYARNSILIVVTNPLDPMTYVALKTTGMHKDKVMGMGGLLDLSRFKSFIREAANVSGESIQAMVISEHGENMLPLIRFCCISGIPLIDFISAEVQSRIFENTRKVAADVIALKGATTYAPGNAVAIMAEAIIKDKKSVVPVSAPLDGEYGVSNICIGVPVVLGENGIERVIELKLNPMEREIFHKGINSVSEAIKAIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHS2</accession>
    <name>A0A6A8FHS2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000082">
        <property type="protein sequence ID" value="MRN68506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="132" mass="15256" checksum="EE7927591BCBD058" modified="2020-06-17" version="1">MPNEETVLIVCRNAKKLQDLANVILDAARIESNTIQLYKESVNLKDIIQDALKEIENSHNDRLEVIYEPRDIFIVADKDRMTEVISNLLSNALKFAKEGKIFVNVKEKNINKQVIVSVKDTDYRSSWRYDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHT4</accession>
    <name>A0A6A8FHT4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_04555</name>
        <name evidence="3" type="ORF">FIO03_03695</name>
        <name evidence="4" type="ORF">FIO04_03785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000062">
        <property type="protein sequence ID" value="MRN40296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000102">
        <property type="protein sequence ID" value="MRN61144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000174">
        <property type="protein sequence ID" value="MRN68801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="89" mass="10631" checksum="77CF8410C3A13302" modified="2020-06-17" version="1">MKHRSRLEIIAEILETANSSKSIQAKIMHRVYLSYPQLKEYLALLLENGLIEYRQTDRIYRTTSRGMRFLEIYRQLNDVVVMTDNIIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHT6</accession>
    <name>A0A6A8FHT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000087">
        <property type="protein sequence ID" value="MRN68526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="167" mass="18003" checksum="4278191682ADF1E0" modified="2020-06-17" version="1">MSQNNSTSTITNYISKSAKIGQNVKIWHFAYVGDDTEIGDNVMIGSLSHVDYKVKIGENTRIEGSVYIPPLTTIGKNVFIGPGATFTNDPYPMSPKMSGVIVEEGAIIGSRAVIRPGVRVGEGSVVAMGAVVTKDVPPRMVVMGHPARVKYSRAEYDKKKAEWLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHU2</accession>
    <name>A0A6A8FHU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease subunit beta</fullName>
            <ecNumber evidence="4">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_02410</name>
        <name evidence="3" type="ORF">FIO03_01490</name>
        <name evidence="4" type="ORF">FIO04_03850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4"/>
    <dbReference type="EMBL" id="WJXE01000024">
        <property type="protein sequence ID" value="MRN39880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000028">
        <property type="protein sequence ID" value="MRN60716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000177">
        <property type="protein sequence ID" value="MRN68814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="122" mass="13380" checksum="7DF166706DF47534" modified="2020-06-17" version="1">MIPGEYILSSKPVICNENRNTIKITVKNTGDRPSQIGSHTHFFEVNKALDFPRQKAYGYRLNIPAGTSVRFEPGDSKEVDLCEIGGHRIVYGFNALTMGGLASSAVRNAAFDMAKRQGYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHZ8</accession>
    <name>A0A6A8FHZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO02_11615</name>
        <name evidence="7" type="ORF">FIO03_02110</name>
        <name evidence="8" type="ORF">FIO04_00150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum02</strain>
            <strain evidence="7">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000359">
        <property type="protein sequence ID" value="MRN41671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000048">
        <property type="protein sequence ID" value="MRN60839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="PTHR21346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN41671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN60839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="117" mass="12108" checksum="6C78AD01714342C0" modified="2020-06-17" version="1">MVVDIGSLASTATSVGFGGITGFLIGYAIKKVVKVILVIVGLVFVAFVFLEYQKLITVNWTKIQASTIAAFGNVTSDQLLARSGIPGTDHIASSMSSFGIPLTGSLTAGLILGFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI18</accession>
    <name>A0A6A8FI18_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="2">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">coaD</name>
        <name evidence="4" type="ORF">FIO04_00255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="160" mass="17271" checksum="D73B25F239DCB199" modified="2020-06-17" version="1">MTDKFNVVATGGTFDEIHIGHLALLSKAFEMGKRVVIGVSSDEFADMVKVKGKITHTYEQRVANLRLVIQANFGDVIYEISKLNSTYGPAVISGEVNALIASSETAKKGSEINEIRTNKGIKPLAIVIVDMIRAEDGAPISSSRIRTGQIDPQGKLLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI19</accession>
    <name>A0A6A8FI19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000066">
        <property type="protein sequence ID" value="MRN68442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="215" mass="24712" checksum="983057B78EED0AD3" modified="2020-06-17" version="1">MSVPEAKFKINAKEGIVELEGTVTFVDKHLEKFEELFNSAIREAMGMGVEQGLSKQEEIYKKSLPLHTETKLSAMQTNNTRHSSSKQSLTLPPIPVDLKANEDKIGLREFYAQKKPSNHYEKAAVFAYYLSHFNKKTEIRYGELLSCYEEVDEKKPSVFDIVKNSIRYKGWLEPGYDKFATRLTISGENFVKFDLPPQKARWSNKTHATQLSLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI36</accession>
    <name>A0A6A8FI36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000214">
        <property type="protein sequence ID" value="MRN68914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="84" mass="9411" checksum="2B820F8F75A7BFEA" modified="2020-06-17" version="1" fragment="single">MMEINYLDWNNSIDILTKAHQAGLFALIIGPKGTGKTTLVRKFASELKKELYSVNFSLRTRESHLIGSKTLEKGQISFVEGILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI44</accession>
    <name>A0A6A8FI44_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spt5</name>
        <name evidence="7" type="ORF">FIO03_03890</name>
        <name evidence="8" type="ORF">FIO04_02940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000110">
        <property type="protein sequence ID" value="MRN61182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000120">
        <property type="protein sequence ID" value="MRN68636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
        <property type="entry name" value="Spt5_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="5">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN61182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="189" mass="20980" checksum="A7FD6A09718FB21D" modified="2020-06-17" version="1">MSVKENEGDIEEIDDIFDDNESPKKPSDTSDTPTQEPATRPGLDSKFFAIRITGGQENIVANIIQNRINAKKIGIHSILILENFKGYIIVEAPDSNIAYEALAGVRHVRGQIRGELPFKDIEGYLVKKPVVSDLNVDDTVEIIGGPFKAMKAKITRVDYEKQEATVVLLDSPYQIPVTVDANYLKKVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI46</accession>
    <name>A0A6A8FI46_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ureC</name>
        <name evidence="14" type="ORF">FIO04_04415</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="9">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000218">
        <property type="protein sequence ID" value="MRN68924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0533">Nickel</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="13">
        <location>
            <begin position="135"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MRN68924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="575" mass="61965" checksum="5E4B40EE309AE897" modified="2020-06-17" version="1">MVLKLTRKQYTDLYGPTTGDKVRVGDTDLLIEVEKDLITPGDECVFGGGKTLRDGIAQTPGITNANGALDLLITNAVIVDPVLGIVKADIGIKDGKIAGIGKSGNPYTMDKVDRNMVFSACTEATAGEHTICTPGHFDTHIHMISPQQYMDAISGGICSMIGGGTGPADGTNATTCTPGVFNISRMMESVEDIPMNYGFLGKGNDSHPSLATLMEQIEAGACGLKDHEDWGTTAAVLDASLKAADATDIQVAIHTDSINECAYVEDTINAIDGRAVHTYHTEGAGGGHAPDIMKIAGEQFALPSSTTPTRPYTVNTLDEHLDMVMFCHHLNPAVPEDVHFAESRIRAETIAAEDVLHDEGVLSMYSSDSQAMGRIGEVVIRAWQTADKMKKMKGKLKEETGDNDNFRAKRYIAKTTINPAITHGVADHLGSLEVGKYADIVMYPTAFFPAKPKMVFKGGFIAWSIMGDPNASLPSPEPVFYRPMFGALGKAVQKTCFTFTSKAAVRLGVPQKLGLEKVVLPVKNCRNIGKKDMMWNDKTPEIKIDPETYEVTLDGKIATVEPAKELSLAQRYFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI58</accession>
    <name>A0A6A8FI58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000217">
        <property type="protein sequence ID" value="MRN68921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="127" mass="14434" checksum="EB2225CBBC5213B4" modified="2020-06-17" version="1" fragment="single">MAHNTRNPPLTNSDSMMHTEQIFFELASEQRLSILFKLTEHDSKLAKLSKDLNVTMQEVHRNLSRLMAAGLIQRDSGGTFSLTTFGKAIITQTSTFGFLSRNRSYFSEHIFGEIPMKFIHRIGALDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIB3</accession>
    <name>A0A6A8FIB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000253">
        <property type="protein sequence ID" value="MRN69004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="232" mass="26318" checksum="7659DA549AEE8533" modified="2020-06-17" version="1" fragment="single">ESWLNNVEAISSHNLQVIALDLPGFGLSDKPKITYNIEYYSKFISKFIRRLRLDSRSLCIIGNSLGGHIAAEFAINYPLAVSKLVLVSPAGALPVSFKGTPELHNYINIVNAKTVQQVRRDLLGIDKNVKSIEYNYAKMFFQRLKLPRAKEAFMSAFSGSAHAPRLNDRLHKIKAKTLLIWGKDDQMIPVNFLHPFIKMKNCRVILLENCGHSVHMNSSTLFNKFVIDFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIG8</accession>
    <name>A0A6A8FIG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000264">
        <property type="protein sequence ID" value="MRN69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="157" mass="18637" checksum="387181CE10A77BA3" modified="2020-06-17" version="1">MVLDIGITDVLSIAQTVGIVGTLLIALFLSRREVRELSIDIETKVLSDLDEKVHRLEEHLWERPELARVINNVPTLSPEAVYAYDVLNVFSHAYDMHERKVLNDNEWFGWVQWMRTCFRLGTIKEHWKQFQQSQWYDPSFDDFINKEVIAYVEREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIJ6</accession>
    <name>A0A6A8FIJ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper-bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000166">
        <property type="protein sequence ID" value="MRN68776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="108"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="190" mass="19961" checksum="B149E8B2C8985B7D" modified="2020-06-17" version="1">MGLGTVGWSILVMGISLATVIILWVWIGHIGPTYSSNTLIHQQKILRQHFGLSPQPVITDPKLLLTPPSLRDVKNNTANMTTASAGTNSTGGKNVSIVPGASTLADKAFSPNPINVKIGGSVTWTNKDNVAHTVTSGTGPSDPNKGKEFDSGLSTLLAPGKTFSHTFKTAGEIPYFCQIHPTMVGKVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIJ7</accession>
    <name>A0A6A8FIJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000110">
        <property type="protein sequence ID" value="MRN68602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="420" mass="45950" checksum="093255CF7A5A8990" modified="2020-06-17" version="1">MLYSFQWISKDGRLLLTARILRTFAYGFLSIVISIYLKLIGFDGFLIGLILTSTLINSVIFTLVASFYADRIGRRKMLVIYAIMMAISGVIFFVTSNYIALIVAGLIGTINVTGTETGAFLSIEQAVLPQTVKDTKKRNTLFAFYNMVGTFAMSAGVLVSGLPEIIQHQYGLNQIDSIRLLFLAYSILGIGVLGIYLSLSKRVEIMQGREGGGEDQDEKRIPKPLTQTLSPTSKKIVAKLSGLFAIDSFGGGFVIQSIVSLWFFTKFGVDLTLLSYIFSIAGVLTAFSFLASAKIADRIGLINTMVFTHLPSNILLILVAFSPTLPIAIAFYLARMALSQMDVPTRQSYIVAVVKEDERTAAAGITNISRNITQAISPSIAGSILQSVSLLFAPFLLGGLLKIVYDIALYLQFKRDDIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN1</accession>
    <name>A0A6A8FIN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF899 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000309">
        <property type="protein sequence ID" value="MRN69124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="230" mass="27265" checksum="B742279E5A7FA259" modified="2020-06-17" version="1">MVPENEWVESRKALLQKEKEFTIFRDQLSQQRRDLPWVAVNKEYVFEGPNGKQTLSELFEGRSQLIVYHFMFDPSWEAACLHCSFWADNFNGIIVHLNQRDVTMIAVSRAPYNKLAAYRKRMGWDFKWVSSCDTDFNFDYHVSFTPEELAKKEAFYNFITQDPHSSEREGVSVFFKDLAGRVFHTYSAYARGIDMLNVAYHYLDLVPKGRDEAGHEFPQFWVRRHDEYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN6</accession>
    <name>A0A6A8FIN6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">FIO04_02970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="WJXC01000122">
        <property type="protein sequence ID" value="MRN68642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="154" mass="16843" checksum="57D09195C1EB4068" modified="2020-06-17" version="1">MDKVRIGVVVSEFNREITFPMLGNAKRQAKKMDAIITYVCYVPGSYDMPVIVQELLKKKDVDAAVTLGAVIKGETNHDEIVAGNAARLIADLSVKHSKPVALGITGPNMSFKQAKDRSEIVPIRAVISAVNMATRIKKIREENSRLVGKLKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIU0</accession>
    <name>A0A6A8FIU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000337">
        <property type="protein sequence ID" value="MRN69184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="205" mass="22969" checksum="4B171FE8CAFB6316" modified="2020-06-17" version="1">MNISEMGISSEVVDANFFYIDIVGLSNPLLSVTKQREKIENLFGIVKSCDAFKSDDMKIHLPTGDGMVIGFLLNPQLPLELGTQLHRKLRLYNRSKESPDDFIGVRIGLSSGPVFAVNDIKNNQNFWGPGIILARRVMEMGDNWHILIADVLAEKLIPLRGEYKKIIKSIGSYNIKHGQAIRLYSAYSNEFGNPEPPPKRDLVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIU9</accession>
    <name>A0A6A8FIU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000150">
        <property type="protein sequence ID" value="MRN68728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="325" mass="37285" checksum="D0C400C58DBB74BF" modified="2020-06-17" version="1">MHRYESKVLKSNPLKDPYVRELVIYLPPGYRQSDSAGYVTVYGLVGFGGQGKMMLNVDPFTETIEDRMNRLISHGKCGPMILVLMDCFTRFGGNQYINSSATGRYEDYIIKEIVPFVDKSYNTAAGARALWGKSSGGYGSIVLGMRHPEIFHGLADHSGDSAFEYCYLPDFPKAMEAFRKVGSPGKWLANFWKKPNRHQANDAPPLNILAMAAHYSPNRRSKEMGVELPFDLNTGEISQRVWNRWLSFDPVRMVEKYRKNLSKLKLIYIDCGTKDEFNLQWGARILHSKLERNNIDHYYEEFEDGHMNISYRYDVSLPKIYLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX2</accession>
    <name>A0A6A8FIX2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2 6">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purM</name>
        <name evidence="9" type="ORF">FIO04_00425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2 6"/>
    <dbReference type="EMBL" id="WJXC01000010">
        <property type="protein sequence ID" value="MRN68147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="182"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="357" mass="38907" checksum="118053B7AA400FCD" modified="2020-06-17" version="1">MRNKSKVTYADLGIDIKMISKAQKKIGAMISGTHLLPFTGKVLSGYGGYAGLIDLGSRVLALHADGVGSKIIVAQMMNRFDTIGVDCIAMNVNDVICVGAQPLAFIDYIALKSANKILVQQIVKGLVEGAQESNVPIVGGETAVLPDLISGFDDGNAFDLAGMVLGSVARKSELVLGQRITVGDVILGVESSGLHSNGYTLARKVLLSKYSLDEIPGYMHHMLGEELLTPTRIYVKPIIEILNRRKSIRIHGLAHITGGSFTKLARLNKRVRYMLNNLPSVEGIFKQIKVEGRVDINEMYRTFNMGIGFCVILPRNSVDKVFSIFEKYRMRCLQIGTVDKKGSGNVIVRLNGKNNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY3</accession>
    <name>A0A6A8FIY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7">3.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_03535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000159">
        <property type="protein sequence ID" value="MRN68752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="6">
        <location>
            <begin position="120"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="353" mass="37520" checksum="425DE5CF7F3D57E2" modified="2020-06-17" version="1" fragment="single">VGAELSWCGCNPLSTQDDVAASLAIDENISVFARRGISTKEYYEDINSAIGIRPNITIDDGADLTVEMHKNMNGSKSVIYGGTEETTTGVVRLRALQNAGKLKYPIIAVNDAETKHDFDNVYGTGQSALDGIIRATNILFAGKNVVVAGYGHVGKGIAKRAAGMGANVIVTEVDPIAALKAKLDGFSVAQMISASEIGDVFITTTGCKDVIDGGDISRMKDGAILANAGHFNVEISIPAIEAQSTSPKQVNEHTMQYNLKTGSRIYLIGEGRLVNLAAAEGHPSEVMDMSFANQFLSVMKLAESKGSLKPLVYGIDTSQDKQIALAKLESMGIHIDALTDDQRLYLEGFSEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ18</accession>
    <name>A0A6A8FJ18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4242 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_02935</name>
        <name evidence="2" type="ORF">FIO03_01205</name>
        <name evidence="3" type="ORF">FIO04_03820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000032">
        <property type="protein sequence ID" value="MRN39983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000021">
        <property type="protein sequence ID" value="MRN60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000176">
        <property type="protein sequence ID" value="MRN68808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="78" mass="9019" checksum="8F7EDE281D9C3161" modified="2020-06-17" version="1">MPRFLDVHPMKGLDEDILKKLQDSPLDEFSVKHLNILYNPEADKCFCLLEAPTKEAVEKHHEKIGIKCEWITEVKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ19</accession>
    <name>A0A6A8FJ19_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_07070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000495">
        <property type="protein sequence ID" value="MRN69445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="178" mass="20734" checksum="C2799F18CCF8B70A" modified="2020-06-17" version="1" fragment="single">HYNNVDIPSETRVGDFTSKPTELRLARWIERFFTWLIDFLIVRIGIEILFYAATFPLWFDSNPDRWFRGGASIGFVVRSLIFLAYWTYFESTGGQSLGKRIFHLKTVGVTGQTVNVRDALLESFGKSFLLPIDLILGWIFTNDKRQRIFNRASNTIVIKLRSHTEENSSSNVRYRKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ32</accession>
    <name>A0A6A8FJ32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000373">
        <property type="protein sequence ID" value="MRN69251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="56" mass="6179" checksum="E2DE921DCA9206A8" modified="2020-06-17" version="1">MSSEIMEKLQKRVKAARTRPVFFYDYSNVSLMTDFAPRTPGLGGGSAAAYFGIKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ40</accession>
    <name>A0A6A8FJ40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO03_01480</name>
        <name evidence="10" type="ORF">FIO04_03840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="9">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urea transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000028">
        <property type="protein sequence ID" value="MRN60714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000177">
        <property type="protein sequence ID" value="MRN68812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN60714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="83" mass="8338" checksum="F734BE71E6C40BEA" modified="2020-06-17" version="1">MLGLGVLEGAANFSTGNPGLDFFYTLFNGISEVPLFSSLINGILILAVVILASQTAGAKMVLSGLIGAGMAILFGAPCGAQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ49</accession>
    <name>A0A6A8FJ49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000024">
        <property type="protein sequence ID" value="MRN68227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="369" mass="40577" checksum="A05DF37413C1A58F" modified="2020-06-17" version="1">MIPINQPWIGEEEKREVLSVLDESALTSAAKDGGKRVQALERLLKDYLKVQNVVSVNSGTAALYSALLALGIGQGDEVLLPSFTFVATANSVVAAGAKPVFVDINREDYTIDIADLKTKITKKSKAIIPVHLYGHPADMDEISEIAYAHSLDIIEDACQSLGSLYRNAQTGTLGKLGCFSFYASKVLTAGEGGAVATNDDNLANKIKMIRNHGMVEGYDTRVLGLNLRLPELSAALAKAQMDKLQKLLDLRRRNANVLTGLLLPLTEEGRINIPHETAKKRYNWYLYTVTFQKDYLREKVRRALASDKIGAAVYYNPPVHKTPYYQTITSTKGLPNTDWASEHVLSLPVHSFMGAEDLERIATSIEKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ58</accession>
    <name>A0A6A8FJ58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000182">
        <property type="protein sequence ID" value="MRN68832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="45" mass="5135" checksum="9C0B2FF4448E5485" modified="2020-06-17" version="1" fragment="single">HIVCPFLTIVHIIPKVHGGTHDDSNLQLLCLSCHRIKNFRNMNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ82</accession>
    <name>A0A6A8FJ82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000194">
        <property type="protein sequence ID" value="MRN68862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="139" mass="16074" checksum="C0F8579597599209" modified="2020-06-17" version="1">MKNQQRQQFYKEFCDTVVAIDPTIRFAGIVDTDGKLLGISERKGLTPLLTPEQRAQYAITAATRQFTRLRWEYHLGKIHYASSHYAKLIRATIPITDTESQLWYVLLLTFDVETDNFHEIITKGIIPMVSQNTTQLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB1</accession>
    <name>A0A6A8FJB1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000448">
        <property type="protein sequence ID" value="MRN69374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ProRS-C_1" evidence="3">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="212" mass="24011" checksum="2EC1C124F8605B92" modified="2020-06-17" version="1" fragment="single">VMMHGDDKGLLLPPYIAPIQIVVVPIFRDKDSKVVKSKAQEVADVLRKSGLRVLVDERDEYTSGWKFNEWEVKGVPLRINLGPRDIENAQVELVRRDTMQKSTVNCSTLVDSVFSILNEIQTNLLLRTKEILRQYMSKAISYDSFKSILNGKGGFIYTGWCGDQSCETKVKEETGADLRVLPFDEQQETGLLSNCVYCRQPANKIAVFARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC5</accession>
    <name>A0A6A8FJC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000208">
        <property type="protein sequence ID" value="MRN68902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="230" mass="25028" checksum="8E25CC06FDA4FC0C" modified="2020-06-17" version="1" fragment="single">MFPFVLQLGTPVNIITTPPLVYAQSCVNSSSTTLKPLLNTGGLYIFHPTNERSMGQEKTCSTPRAQLIIINHFDNTGCSTGCLPASNSTITVLGDNPKPIAFKVSTKDTTVTLGPGHYTVDEPRMSVFYGQVLSPDCSGVISAGETKKCIIINSYSNNVQTWLDKINNIKIQFGYSPPYPFVGNVTQLNFKVSSANTSKGLDLTHIHIAVIKNVTANFNNSNTINNKNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE2</accession>
    <name>A0A6A8FJE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin cobaltochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000576">
        <property type="protein sequence ID" value="MRN69555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="255" mass="29501" checksum="CB40ED53352A07F1" modified="2020-06-17" version="1">MKKAILLIIDRGSREPEVRQELEDICSLVKTNGGYYYADYCFLEVLPPFIEEGIKECQENGADFITVMPYFLYPGMKLKDSVRQSARICKIKNLNLVITKPLSYHSMMTQLVIDRINCLKKEKSIRYSDLECDILLIGHGSSDKNARDAFVYIVNTLRPFYRAVKFCFLELDKPNIQQGLKNLLDNNPKVVILMPYFLHKGAHIKRDVIADVNEALKKHPFENAFMTSHLGVDKKLIDLLIERAREVEEKRFGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG5</accession>
    <name>A0A6A8FJG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000232">
        <property type="protein sequence ID" value="MRN68958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="38" mass="4684" checksum="D8B45F17D3C69967" modified="2020-06-17" version="1">MDTKRLRYYSEFFNTAEMDFTFYEKLNFNMTKGTLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM3</accession>
    <name>A0A6A8FJM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl Co-A mutase-associated GTPase MeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">meaB</name>
        <name evidence="2" type="ORF">FIO04_04805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000252">
        <property type="protein sequence ID" value="MRN69002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="307" mass="33003" checksum="838476A80A93D242" modified="2020-06-17" version="1">MHPIVEGLFQGDRRSLARAISIVDDDEPDSHIILRQIFNKTGNAKTVGFTGAGGAGKSSLIEKLVPALQDLGYKIAIIAVDPTSPITGGAILGDRVRMRTTMDDQNVFVRSLASRGAIGGISRSVRNVIRILDAAGYGLIIVESVGAGQVEVQISNVVNITAVVLSPQTGDSIQAIKAGLTEVGDLYIINKGDLDGSTSLYNSITDLIGDTPRKPVVIKASAKTGSGIKDVAVNIDKLLRGKGDNYRDQEKRMLEVELRDMVLNMVEEKVSAVLREDNRYHDFIAKIVNKELDPYVAAEQLAAVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM8</accession>
    <name>A0A6A8FJM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaJ</name>
        <name evidence="8" type="ORF">FIO04_04855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000257">
        <property type="protein sequence ID" value="MRN69012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="378" mass="41669" checksum="33EE7DDB0C4F8408" modified="2020-06-17" version="1" fragment="single">YETLGVQKNASKEDIKNAYRKLALQYHPDRNKTPGAEEKFKEISEAYAVLSDEEKRKRFDTYGHVGAEEVFRGSEANFDEVFKDMGFGGFRDIFDQIFGGRAGGGGFGTAAGDPSGFGFSFGGGRRKGRDLLYDVELTLEEVLKGRKDEIELPKLERCTTCGGSGASPGTKPRKCSVCNGQGQTRRIYSQNRFSTFVSLEPCQTCRGQGEIIDKPCNICDGAGKVRKNKKIRLEIPAGVEDGVTLQMRGEGEPSETGSPGDLLIRIHVKPHPLFERLENGHLLYTLNLNFTDLALGAEVRAPTLDGNEKLKIPPGTQPNAILKLKGKGLPHYGSYSKGDELVRINVKVPVQLNDIQKSLLKELDRQLRNEDGSARQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJX1</accession>
    <name>A0A6A8FJX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_02470</name>
        <name evidence="3" type="ORF">FIO03_05540</name>
        <name evidence="4" type="ORF">FIO04_05390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000025">
        <property type="protein sequence ID" value="MRN39892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000185">
        <property type="protein sequence ID" value="MRN61499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000305">
        <property type="protein sequence ID" value="MRN69118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="89" mass="10250" checksum="49F96E8C0C21C6BE" modified="2020-06-17" version="1">MPTAYVLINCDLGSEEEILKELKKLTEVIEVSGVYGVYDIILKIKSETMDKLRETITWHVRRIDKVRSTLTMIVIEGQGEKGKRQQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJY3</accession>
    <name>A0A6A8FJY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000359">
        <property type="protein sequence ID" value="MRN69226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="149" mass="17099" checksum="F5EB2963BBA7D84C" modified="2020-06-17" version="1" fragment="single">MPTLIPLARRTRTRAAAMTVFPTPVSVPVISSPRMEMLLEQFVYHLIEMGLAHADKRYIWHPYTQMKDWKKWDNRVIVGGKGFYLIDNEGRRYLDGIASMWCNVWGHGKNEIVSKMSEQLRTLQHSTLFGLANAPSITLAEKLLKLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJY8</accession>
    <name>A0A6A8FJY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_09950</name>
        <name evidence="2" type="ORF">FIO04_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000249">
        <property type="protein sequence ID" value="MRN41348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000087">
        <property type="protein sequence ID" value="MRN68527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="381" mass="42349" checksum="29DD7792C44B684C" modified="2020-06-17" version="1">MTTAVYGLSTEGYRIASSIAVKGFKVSLIDEAARMAISLKPDIARTYPDVSSLIEDEPLLALEPVDVAVSEASYIFFAPKIRKVGQEVKSDVTSKFRDATKAIRKGTSVIYTLPTGIGGNNENMALIEHVTGMSVGKDIFYYYMPISQELISSPEIIVGSLNSKQDAEISKMLYDPDIKGRLNYIDIISAEFMHSIHILGNYAHMASVLEICKNLKVTNIKSEPINRAFSDLYIDDIANGLYDLRAIGSSLGGAGPLMYLVNGSIKGTEGYIKHLIDEIRDLLKKRDLKASRTKVSIAWTLDPYEMRGDKIELLSSLESRLKDYIGDVERQPWSVFDLYPTEKTRIVVACSKLDFARIMTKNKQNPDFIMMKANPVCETIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK02</accession>
    <name>A0A6A8FK02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000051">
        <property type="protein sequence ID" value="MRN68370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="62" mass="7319" checksum="09C06DBAEB2DE655" modified="2020-06-17" version="1">MFIVKKLSKNGVWNAISLIDQNGSFRGEAKFDSKKEALDYLLEYKRRMKHQQQDLEVFSEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK05</accession>
    <name>A0A6A8FK05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000371">
        <property type="protein sequence ID" value="MRN69246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="106"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="303" mass="34331" checksum="53A5099B07AD7AF2" modified="2020-06-17" version="1">MFVETNEDNSISLFPSEASDSQIKDVTILYSESSVDSLINQIYGAYLLGYSDIRIKGKRQILFEHREHIKLTMRKLVGLEIVDEDNSNIAIQFLLDANTLDAEKILRRMNSIVGGMYRDALDGLRLKLEGIKNLIFSRDDEVDRQYFLLVRLIRSAMVDQKLARKLNLSNIDILDYRIAANHLESAGDYIGEFASTVPSISRTKIVDEISEAGSYIEKMQEKSVAAFTKKNRSESVGMIKMYNEFRLIMDSIKELLAKIELTNSESTIAVLNSIHSMDKIAKCWVDIADLVKPVYLTSALQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK15</accession>
    <name>A0A6A8FK15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000330">
        <property type="protein sequence ID" value="MRN69168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="58" mass="6648" checksum="6071487A085C1DB4" modified="2020-06-17" version="1" fragment="single">MKLELPRGMRDLESDELLGINYIKEKFFETTRLFNFKSIEPSPVEMLATLEAKAGPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK53</accession>
    <name>A0A6A8FK53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000336">
        <property type="protein sequence ID" value="MRN69182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="116" mass="13584" checksum="7D486D7AB52B4B33" modified="2020-06-17" version="1">MTINSNSRDSSSASFTGSGIGLPKEDKAGLEDNFHVFINKRKFRFRGKYNLNILDLEHEISKWNKTYTSFLYHASINPEIIYERASEIYEEGRLFQKQIRDIAEKIVHDEELKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK60</accession>
    <name>A0A6A8FK60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF47 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000066">
        <property type="protein sequence ID" value="MRN68440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15203" checksum="AF3644DB4FD1FD9A" modified="2020-06-17" version="1" fragment="single">YREDVLRAAYLMDDIAGYISGVSFRLANMKLTSLKKGKFDEDLEQLIGMVVDAIFKLNEMARALSINPGSTIELAQDVEKLERKVDARYRAVIIKALSEISVTKDLLLLKDAIEGIEGMADKCQETSDSLTILALSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK73</accession>
    <name>A0A6A8FK73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000205">
        <property type="protein sequence ID" value="MRN68893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="165" mass="18892" checksum="BDB1B96D203D6AFF" modified="2020-06-17" version="1">MIAASLNPPTRDEVKKLAMIDIAIMSGLADSLRSILKKYIQIDPYTMSDPFGSGDEYNYSVILDRQEPRRAVAMIKDEYNYSVILDRQEPRRVVAMIASKLEPLPQLPWDDILGDRLVRLSLSKPDANALKNEMMPKDTNNFYQYRRSGKITGFIMFAFQICGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC6</accession>
    <name>A0A6A8FKC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatininase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000436">
        <property type="protein sequence ID" value="MRN69356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="232" mass="25748" checksum="F132F67EA5803C79" modified="2020-06-17" version="1" fragment="single">KTVAMLVFGACENHGDHMPFGSDFFVPMELAKRVAARAGNVLVLPAFPYGVSSHHSDFQMTITLEPSTMIMAIEDICSSLIKNGINRILIINGHDGNIAPIELSARTIKDRYPNVVIACLEAWWTLVGKTKNLFGEWAGLGHGGEAETSVMLSVRPDLVDMKYAPKKTIPKLPRNVRIYWRFSELTKTGATGAPRHASRSKGDETLHTLERLLLGFINNMEKNNWKYGLALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKD1</accession>
    <name>A0A6A8FKD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrahydromethanopterin S-methyltransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03145</name>
        <name evidence="2" type="ORF">FIO04_04740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000080">
        <property type="protein sequence ID" value="MRN61041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000246">
        <property type="protein sequence ID" value="MRN68989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030688">
        <property type="entry name" value="MeTrfase_MtrA/MtxA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04208">
        <property type="entry name" value="MtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="166" mass="18393" checksum="BEFA0EBEB4588E03" modified="2020-06-17" version="1">MANITFIKKLENIAGRLCEILIPIKDEYFIGKGKTVAICTLSSMDLLQTIARTEGVMNRILIVGRLLSENKGIDTLIKFTLKHPELRYIVVCGNDVKGHQSGQALLSLYRNGVSRDGKIIGATGPHPFLTHLHADIESFRKQITIYDLIKCGELETVKATLSSFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKI7</accession>
    <name>A0A6A8FKI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000419">
        <property type="protein sequence ID" value="MRN69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="58" mass="6633" checksum="5B3F7B358D88B02B" modified="2020-06-17" version="1">MSNYSNISHGIHNMGLIESIVWIMTGFIPTLTTMEIAWRIANIRVREEVAMANNTVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKJ9</accession>
    <name>A0A6A8FKJ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000265">
        <property type="protein sequence ID" value="MRN69033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="145" mass="16332" checksum="8C1F5C6673414AD9" modified="2020-06-17" version="1">MSATDQNQKRHNQQYQNILSRFNKILLIGLGQLGLPLAKYVKERGFDTYGYDSSANAIDRAGIIAEIKQAVDFGSVDFDVFIISVSTHQPDDIFSPQIDRLLCIVDKISKEAKIDRTPLSLESTIQKGTSKKVFEMLNLRIGQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKK1</accession>
    <name>A0A6A8FKK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_02575</name>
        <name evidence="2" type="ORF">FIO04_06625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000026">
        <property type="protein sequence ID" value="MRN39913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000437">
        <property type="protein sequence ID" value="MRN69358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="95" mass="10616" checksum="62EBB2CB05A6432B" modified="2020-06-17" version="1">MSDGTGVKYLVPVKQVDKSIKLTDEARAELRSIGMMDEKGKLKLKGVSAKMLKRMKLESVDCPVLKAEVGFVQCYVCKNFHSRITGQVYCKGEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKM1</accession>
    <name>A0A6A8FKM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YjbQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_03900</name>
        <name evidence="3" type="ORF">FIO04_03405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000049">
        <property type="protein sequence ID" value="MRN40168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000150">
        <property type="protein sequence ID" value="MRN68727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="139" mass="15546" checksum="42EFB212270B29DC" modified="2020-06-17" version="1">MTVLGKVLQIKSKGEDDIIDLTKHTAKVVLDSKLTDGIVTVFVVGSTAAITTIEFERGLAKDFPEMLSRVAPKEIYYEHEKMWQDGNGHSHVRASLIGPSLTVPFKDGSLILGTWQQIVLVEMDTRHRERKVVFQIIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKQ0</accession>
    <name>A0A6A8FKQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_05295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000297">
        <property type="protein sequence ID" value="MRN69099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="241" mass="27422" checksum="1F107F2BF7CA288F" modified="2020-06-17" version="1">MSFEILNLSWNFVIYVVASFVIGMAGVIFYINLKALHKKSTNQTDNSVVEAVISEYTRRLQEFERIIGELKVKIDTVELRVLQHPTSQTSDDTSDMTRDSSTDARTSQSKSQLQEHHSRTSDVMESTTITPPSIVTSVKSNPTLHHSTSDYILKLLVEKSRTSREIQNAIGKTREHTSRLMRRLYESNLVSRDSNNKPFKYYITDQGRRELIFHTTTGEAEAPDMNVHSGSQDSQLNVTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKS5</accession>
    <name>A0A6A8FKS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF45 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000306">
        <property type="protein sequence ID" value="MRN69119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="44"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="248" mass="29283" checksum="D6B0C3C9AC878429" modified="2020-06-17" version="1">MSKEDNENLSSLPVHLSNGRILSVQVKKSKRAKQLCLKANIFGLYVVVPFINYEIDEVMRFLDIKKEWILETSEYYGRLRNECGEENLKLNTISFLGKRYNLRITKDLASCVIVSDNLKTITFHVTDRRRYKDDIKRWYLAETEKIVSERIDLIRKRNPKLPAYNRVSIKDQHSRWASCSKNGNLNFNLLLASLPVELINYVIVHELAHLIELNHSKEFWNIVKLLDPEFQHHRKLLHKYGLLTNYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKT5</accession>
    <name>A0A6A8FKT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_03060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000128">
        <property type="protein sequence ID" value="MRN68660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="378" mass="41286" checksum="78A0186A0AE33A2E" modified="2020-06-17" version="1">MNILNIYPAYRSLLVIWVMAIKDIRSSLTERAFMVTSIIIPINFLLLFLLFALTGGQAPTAIVLEDKGPYAQQFLSAMEHSHSFIIQQTTNADAQNLMKKGQIVAIVTVPGSFDSLLRQGKQAQLRVVLNNLEVDFTNDIRRAVPLAITSFYANAFPNQVVIRAHEVDTYSHDTGYVQYLVVSLMVVSVMLGGLLQAGSNAAREYEKGTIKELMLAPASLWAIQIGKILGALLLNSLSVVVMIIVIVFLIGVWPEHWDELFAFVLLLMITFVALGSLIGTLVRRRQAVIPLSIGLSIPVFFISGAFGPAIWGDQVTATITQLQPVYYGIAIFQHAFHNFTTTSTSPAINGFILAGFAAVIVAISALTLINGRGRGVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKX7</accession>
    <name>A0A6A8FKX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Precorrin-3B C(17)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000576">
        <property type="protein sequence ID" value="MRN69556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021745">
        <property type="entry name" value="CbiG_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11761">
        <property type="entry name" value="CbiG_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CbiG_mid" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="80"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="201" mass="22314" checksum="AB703A4261BE9019" modified="2020-06-17" version="1" fragment="single">FENVTKVSAFMVNEEKIGIYQETGEKDWWQNKSLPSNVTVVHNLDDLKSSHFKGALVISDRIIDDPIILEKSVLYRPKSLVVGIGIHRDTNSGVIEYGVKNTMKNEGLSFNSIRNIASINREAGVKGLQDFSSLYRIPVEVYDRNKLGIIPVPNPSETVKRFEGTPSVSEASAILSAKGDLVVPKQKYPPDLTVAIARVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKY4</accession>
    <name>A0A6A8FKY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000184">
        <property type="protein sequence ID" value="MRN68837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="54" mass="5889" checksum="84CE5E0EE3EE1218" modified="2020-06-17" version="1">MTADANETIAHIDEVRGIPHYSYPVALSAITATNADHVNFLVFVNFVNVISTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL23</accession>
    <name>A0A6A8FL23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000572">
        <property type="protein sequence ID" value="MRN69548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="73" mass="7869" checksum="040A55C26D23D5AE" modified="2020-06-17" version="1">MRIVGAAVGPALAGMYMQSNQSILRINGIAQYFPSAESYNLIFLTATALSILSIALAIILRRRAIKLAIPNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLC2</accession>
    <name>A0A6A8FLC2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_04680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000240">
        <property type="protein sequence ID" value="MRN68977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="318" mass="36550" checksum="53007B11AFDE20B0" modified="2020-06-17" version="1" fragment="single">MDIEDRLFLISRDPTEEVVTEPELRTLLETVARPKHYIGLEISGMLHLGSLILTGFKINDFIKAQVQCTVFLADWHTYINDKLHGNWAKIKEISEYYSEAFRYFCPGISIELGSELYHRTNDYWKDIVRFSKHISLPRTIRSLTIMGRTGRENLDIAQLLYPPMQSVDIKALELDIVHAGMDQRKIHMLVREIFPKLGWKVPVSVHHHLLPGLSEPLTPESSEASSVDTETFSKMSKSNPASGILIHDNEETIREKIMRGFCPLGTAENNPILELIRYVVFHENNEVVIERPQKYGGSVSYATFKELERDYADKKIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLD1</accession>
    <name>A0A6A8FLD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoglutarate ferredoxin oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000417">
        <property type="protein sequence ID" value="MRN69329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="282" mass="30977" checksum="8C7DAE4ABAB52256" modified="2020-06-17" version="1" fragment="single">MIGGAQGSGVDSAANIFSRACFQGGLHIFGNREYYSNIKGEHSYFAVRVSEDPIRSHLDDINILVSFDAETIFRHADKVTSGGAIIYDSDLSSTTLQEVPTIDEPAAKRIRELLEKSENPITVNGMVNFAKNNGAVLYDIPYFGILKQFSVEINEPALSKLTRMINVMALSASMAILDFDKEILAKAIKVIFKAKPKIADGNVLAANYAYEYVKSRFDLSQSQFKLSCKPQSAEIILVQGNQSSAMGKLVAGCRFQTYYPITPASDDSEFLESNQIVEQTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLD3</accession>
    <name>A0A6A8FLD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000194">
        <property type="protein sequence ID" value="MRN68860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="209" mass="22849" checksum="F2FCE67C8EE28F20" modified="2020-06-17" version="1" fragment="single">MDNKKLVLDTSVIIDGEVTKMIETGDISGASQIIIPLAVLDELQSQASSNKEHGFVGLSEIKKIREQCSKKKIDLLFVGARPTLDDIRLAKHGRIDALIKDVAMREGATLVTADYVQALVAEAQGVQSMHVSTPAKTSNLEFEKFFDENTMSVHLKEGVLPMGKKGKPGNSQLVKLDEERCSYSQLTHIIEEISEASRVEGVGSVEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLD4</accession>
    <name>A0A6A8FLD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_06495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000420">
        <property type="protein sequence ID" value="MRN69333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="121" mass="13652" checksum="AA7763A6F45A97D3" modified="2020-06-17" version="1">MVLFFSAFQMNIGGSEWIIIAMLALFLLFGTKKVPQISKTVGKAMGEYQRAQELLRKEIENATTATRPMEDNKMHLMGTRIDGPVASEHEKLETIARSLNIDCLGKTDDEIRSLISRSLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLE6</accession>
    <name>A0A6A8FLE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000253">
        <property type="protein sequence ID" value="MRN69007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="170" mass="18170" checksum="C0AB0E597EBCCABE" modified="2020-06-17" version="1" fragment="single">MPIRYAEATSHHHNNHTPPTSGHVNNNSNIKHFHPPAHSILVCCAWNSQFTNGELTYKTVGGNTAERQALNAAADTWMKSVKGLKLTQVSGKKSTADIIFGFQNSAASGSSTIGSKSSYGDTVGQTTTYFDGSGYIDRVLVNIATSAFGNTFTTAQLKQIAMHEIGHTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLF7</accession>
    <name>A0A6A8FLF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000201">
        <property type="protein sequence ID" value="MRN68880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="292" mass="33176" checksum="1CF83742651431D5" modified="2020-06-17" version="1">MNRRNTEVNPLMELFSQYLLKIDEALRRELDLYSWSEFYAPLRYACDGGKRIRPLILLLSAESIKTKAIGLVNVTENDAAFMAASAIELLHTESVIHDDIIDEENIRRGKPSFHVKYGYNNSILTADFVLGIILNIGSKMDDSRVSGELSKAAIKMSEGEIMEIKFGKDRKIKEDDYIKVLEYKTASLFEASAKIGAILSGGVEDEIHAMAAFGSLLGIAYQIHDDLMDWSNEDRLFNLLVKKNGQSREFVERMEGLYLSYSTKAKNELRKIHDSTPKRHLERLTDLASLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLK4</accession>
    <name>A0A6A8FLK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000476">
        <property type="protein sequence ID" value="MRN69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="49" mass="5863" checksum="6436E173AEC5512D" modified="2020-06-17" version="1" fragment="single">MAKDPVCGMFVEEKPDAIRYNKDGREYYFCSKQCLDEFIQPEKELKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLM9</accession>
    <name>A0A6A8FLM9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_06940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PdaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000480">
        <property type="protein sequence ID" value="MRN69419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="104" mass="11267" checksum="75811D03D238D30A" modified="2020-06-17" version="1" fragment="single">MEGGNNTTKFFSDASSFVAKMIFFTKGKGLHKEYLTSFELALRDAAISDLNLVSVSSIMPPECKTVTREEGRKHLLPGQIAFTVMAKSATNEPNRLIAASIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLV7</accession>
    <name>A0A6A8FLV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_04945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000264">
        <property type="protein sequence ID" value="MRN69030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="184" mass="19927" checksum="0D7EB4E4677FC394" modified="2020-06-17" version="1" fragment="single">GLGVNFTGMRLLGSNGHSHGGSQVDNVHVDTAKEHEDLNVKSAYLEVLNDTLGAAGVIAAGVIILTTRFYLADPLISIGLALFILPRTWSLMKKSIHILMEGVPANISPEEVKNSILEIKGVTGVFDLHIWTITSGINAVSGHVVVIDRSRSQTVLQDINAILEKKFKINHATIQIESYHSEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLX1</accession>
    <name>A0A6A8FLX1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps11</name>
        <name evidence="7" type="ORF">FIO02_04575</name>
        <name evidence="8" type="ORF">FIO03_08130</name>
        <name evidence="9" type="ORF">FIO04_07405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000063">
        <property type="protein sequence ID" value="MRN40300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000352">
        <property type="protein sequence ID" value="MRN61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000538">
        <property type="protein sequence ID" value="MRN69509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_S11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN40300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN69509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="136" mass="14351" checksum="2E4A5E7CD23E13E4" modified="2020-06-17" version="1">MSTDIAEVTQYKWGVAHIFSSYNNTLVHITDVSGAETVSFSSGGRHVTADRYESSPYAAMKSAVAAADAAKTKGINALHIRVRAVGGVGPRIPGPGAQAAIRALARAGFRIGRIDDVTPVPHDTTRKPGGRRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLY5</accession>
    <name>A0A6A8FLY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000567">
        <property type="protein sequence ID" value="MRN69543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="161" mass="18495" checksum="9D9DDF47EB5E109A" modified="2020-06-17" version="1" fragment="single">MHRGHNANDLVGSLEELGLSRYEAGAYLTMIRKGSLAASEISYYANLPRTKVYSTLKKLEKKRLSIVSQSKPLICSAIPPEEAFREIVKLYERRSKNMKKIVDRLQRITEEQRPKASEERRYYILDPISTLEKMKSLIANSKSSVYAILDSWGIQLIIQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM22</accession>
    <name>A0A6A8FM22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000577">
        <property type="protein sequence ID" value="MRN69559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="144" mass="16352" checksum="6075E70EFF2DC935" modified="2020-06-17" version="1">MMIEGDDLSEKKLRGSGGHVFAKVTDEEQKKGNLGGPDLFLAGVGRLNEDRFSKYYCNKCEKEFQGSPTINYEKPNEDVGEGVTLIEKGEYRCTGCNNTIAQYRKFNSPEEPSRTRGSRDDNSNNRSRTGWIHFNSIFSWHDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMJ0</accession>
    <name>A0A6A8FMJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000485">
        <property type="protein sequence ID" value="MRN69427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="197" mass="22539" checksum="6522D18AB73311BD" modified="2020-06-17" version="1">MTIKILGVASSMREGSYGTRALKRVLDAAGKHEAKTRLLDLRSIRMPMFNPDILNEHHQQMEKVIEDLNWADAFVLASPDYHGSMSGAMKNFLDFYWEEFAGKTFGYICSSHEKGLTVMDQMRTAVRQCYGWSLPYGVSINGEEDFNEKGEIVNSLLVKRLKILARDLVVYGKLIRRQFLQDISTEVSDTFAARYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMM8</accession>
    <name>A0A6A8FMM8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000508">
        <property type="protein sequence ID" value="MRN69467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6637" checksum="1B47018DF642CD2B" modified="2020-06-17" version="1">MFKVDLFRRKEGTIKVFRCKYCNLQFEDKERLSRHSRKAHSEKGGDMPNRNPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMP2</accession>
    <name>A0A6A8FMP2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps15</name>
        <name evidence="7" type="ORF">FIO04_06375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000407">
        <property type="protein sequence ID" value="MRN69310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="149" mass="17089" checksum="D1DF3595366F2982" modified="2020-06-17" version="1">MARIHAHTRGKSHSVRPTSKNAPPWLTSSPAELTSIVIQLSKEGLTPSAIGTRMRDEYGIPLLKTIIDKTITEVRSENGIKQDMPEDLHQLVQKALALQRHLRTHNTDHRNVRSLELIEAKIHRLSKYYKRNEKIPKDWKYASVIAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMR6</accession>
    <name>A0A6A8FMR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000536">
        <property type="protein sequence ID" value="MRN69507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="224" mass="25936" checksum="870B9F16855BFDC4" modified="2020-06-17" version="1">MATSKNLENIADGFSEPKKRLLYYLKVMQHAGLEELAKAMKISRMAVHKHLALLQERGLVQSLETTGHVGRPRKMYQLTSQSKTIFPKSYSAIATHALDFIERNMGKAAVEKVLRERQSELFDQYYKRLRNLEYDKKVKELAKIRDEEGYMAESKREPKNYGKHVLLEYNCPIIHIAENHWEACSTETELFEKLLGADIETTHRAAKGDLVCKFVIKERKEGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMS5</accession>
    <name>A0A6A8FMS5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CDC48_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000545">
        <property type="protein sequence ID" value="MRN69517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="54" mass="5970" checksum="14882704EF734324" modified="2020-06-17" version="1" fragment="single">MPQGDNLKILESYTRDVGRGVARIDYESMDSLSASTGDVIEIRGKRRTVAKCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FN11</accession>
    <name>A0A6A8FN11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000473">
        <property type="protein sequence ID" value="MRN69410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="106" mass="11985" checksum="02BC0425866B1447" modified="2020-06-17" version="1">MTFNRENNMENWDELKPEGNRKELYHKLSQKFKQDSSILIVGHEPYLSTLIGEVISEGNRVGTAGGLVVLKKAGLAKVRITSSSHQMIHGELSWLLTPKHMKKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNA0</accession>
    <name>A0A6A8FNA0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="8" type="ORF">FIO04_07250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000516">
        <property type="protein sequence ID" value="MRN69480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="70" mass="8192" checksum="0FF05944293D9CED" modified="2020-06-17" version="1">MRHLIRKCPKCASYTLKYSCEKCKVPTIDAHPAKYSPDDKYARYRIADRYIQSEEVSDSEPLKVDHENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFD3</accession>
    <name>A0A6A8FFD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_00625</name>
        <name evidence="3" type="ORF">FIO03_00435</name>
        <name evidence="4" type="ORF">FIO04_00030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000004">
        <property type="protein sequence ID" value="MRN39538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000007">
        <property type="protein sequence ID" value="MRN60509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="151" mass="17299" checksum="42578624F1DB81B4" modified="2020-06-17" version="1">MGRAKADSNKPSEEKLPEWAEHEIKSVQFGDEQVIKRSGYILDTYENDFKIDIQLYEPLPDNRTIIEGLDVPKSMSIGEFRKGFVYEFKIKMFKGDLSAKLVEFLKTKFSLDMDAIYRFELEDLQLMEIESDVSSSPPMSAEAAGNDIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFH3</accession>
    <name>A0A6A8FFH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="104" mass="12207" checksum="9CED8FD75EA73885" modified="2020-06-17" version="1">MQADRSPPIKGKFYFIYDDNLNLVLEDKTKRGLEVRERNNDDKYNVDADKGMIHDMDGIGHKVGIRWYFPKSKYQVEDVIKIAEEMDARYKAIQEMTCPDDDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFI2</accession>
    <name>A0A6A8FFI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_06400</name>
        <name evidence="6" type="ORF">FIO03_02900</name>
        <name evidence="7" type="ORF">FIO04_00365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000107">
        <property type="protein sequence ID" value="MRN40657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000073">
        <property type="protein sequence ID" value="MRN60993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN40657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN60993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="145" mass="16430" checksum="0EA34FACA2EE7679" modified="2020-06-17" version="1">MDETDVKILGKLLSDARLSYRRIADEIGVSPPTVLARVKKLEKDSVIKFYSAILDHEKLGYDLTAIIEVTSVKGKIAEVEKHIAKFPNVCAVYDITGLTDMIVIAKFKNRTQLSNFVKKDLALPYVDRTNTHVVLITVKEDFRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFM6</accession>
    <name>A0A6A8FFM6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GDE_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000017">
        <property type="protein sequence ID" value="MRN68185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="PTHR10569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="464"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="896" mass="102031" checksum="4593C4F489F4F1BC" modified="2020-06-17" version="1">MVRTLDKTHTVLSYIDGSLKNATIVNGDNKFDGFIFSLLNPPVPLGGNIVSLDIYVDEIPVPKKSIFIATSEDVVNAATLSEDRPIPFKPFQSARFLIIKDGGLEEQSKHKIVILSKLEGFEQIIVPFTFNDYLSNRKERIFIPSNMMDDSESNTSNEDTIFKNFTTPLILSGKQAYIVCSSNASLSANWSWMGTRYDNGGLYVPPARAFGRILVEISMDDGVRKRLPNFVVSSRHENGFLYTRHEVAGLQVKRTLFVPLDNKGFVMKLELLDREAGYTKLSLKKKTEKSRRKIRIHFVVDGNITSYGLAAISQSNFSKLLTRDNCLQIQTAAKKNLAHFYGTIGVAPKSMRPSRVLMDSFDNDLEISYDLDIEAGNTSELALVAAGGFTSSEDCLKEYRYMRDNYKQLLESTQNHFKSISCSTLNLASSSQIPHQHSTILKLVKAFEKAKTSMEYLKAEYDGLGPGICAGLPRFPNYWARDTGWSLRGYLAIGDYRFVIAVIENFLLHQAKKTSKLAMKGELPMIISGKSFLHDSTFGSADSTFLFPWAIREYVLATGDINYLKNRWKQIVDLVNWGFLKDVDRDGLVENGFTGVAEKLPIQDSTWMDHIDRRKSANDVQALFCESLKIGSELAMIVDDNYNQERWSRCADQLRGKVEREYWNNKDGFYYDTIRRDGTKDSSIRPNALVMLLTESIGDRIKAHSVLTRIEKNDLTTPWGVRTLSSLDPKYHPSLYHDGAVWPLVTGWAAISEIKINRLEQALYYIESMAQRILSENGMYAETYRGDRPEPFNSCILQAWSVGMYVYAMQEMMLGMRLNMLENRIQFEPHIPESLRHNSLPLNFEHHFHIMQQSQRCRIIVDPNREKISIIMRKNEQIDKAPEIFSNSYSINIEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFW5</accession>
    <name>A0A6A8FFW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplX</name>
        <name evidence="2" type="synonym">rpl24</name>
        <name evidence="5" type="ORF">FIO02_06380</name>
        <name evidence="6" type="ORF">FIO03_03590</name>
        <name evidence="7" type="ORF">FIO04_01185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000106">
        <property type="protein sequence ID" value="MRN40653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000098">
        <property type="protein sequence ID" value="MRN61123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_L24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN40653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="135" mass="15119" checksum="77AE861D94BB677F" modified="2020-06-17" version="1">MAKINPKLLHVPSHLRDSRIGSTLSDNLREQYGSRSCRLVKGDSVRVLRGEYSGIEGKVEKVNTQKGTLSIEGIQREKVKGGNVKVQIHSSNLIITGLNLDDKYRKNKLQRNLNLSKESTDSKHTPKTQKQEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG72</accession>
    <name>A0A6A8FG72_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Probable cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobQ</name>
        <name evidence="8" type="ORF">FIO02_00820</name>
        <name evidence="9" type="ORF">FIO04_00870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000006">
        <property type="protein sequence ID" value="MRN39577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000025">
        <property type="protein sequence ID" value="MRN68234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN39577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="280" mass="30956" checksum="E046B9558205BB5A" modified="2020-06-17" version="1">MIQGTSSGAGKSTIVMGLCRIFSDLGYRVAPFKAQNMSSNIHIITEKSESKEIALAQAIQAEACRKRPDVKMNPILIKPLGNYRSRVILNGIFYSEMHAKEYYETFTLQKGFPIIIEALENLRIENDIVVIEGAGSPAEINISKYDIANMLLAKKVEAPVIIVTDIERGGCFASIVGTLKLLKPQYRSLIRGFLINKFRGDPSILESAIKSVEKITRKKNFGVIPKLAFNLPAEDSLDGASKVEIPSRAWSREIDIVANSIKNKISIDEIMTNVVGLDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG95</accession>
    <name>A0A6A8FG95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb</name>
        <name evidence="6" type="ORF">FIO04_01165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000036">
        <property type="protein sequence ID" value="MRN68291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="85"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="263" mass="29391" checksum="1A2D0FA69947D128" modified="2020-06-17" version="1">MPVKGSEWGTFITDGAIHNRSRTGIPSSLARYDIGLSTVIGWTNKDSIGHRLDEAMHSRMKKLRTWDSRIHLHTSVEKSLKQAFNELDSLKDKLGLSDVIVEKTAYIYRKAEERALLRGRAISSILAAAVYIACREIGMPRTLNEIAASSNIKLRTLAMDYRLLVKKLDLKIPLVDPIICIAKIANKANLTEKTKRQAMGIMHDVLKREISAGKRPMALAASVIFLSAMNTGENKTQRDIARAAGVSEFALRIRIQDLKNRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGC8</accession>
    <name>A0A6A8FGC8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphopantothenate synthetase</fullName>
            <shortName evidence="1">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000034">
        <property type="protein sequence ID" value="MRN68284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02224">
        <property type="entry name" value="PPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002855">
        <property type="entry name" value="PPS/PS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038138">
        <property type="entry name" value="PPS/PS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695">
        <property type="entry name" value="PTHR40695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02006">
        <property type="entry name" value="PPS_PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004853">
        <property type="entry name" value="UCP004853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="258" mass="28312" checksum="AFA92CAF6DF73322" modified="2020-06-17" version="1">MRGKIPSSHPRLKSLVVRERLVNGFLRGLVAAEGLIAHGRGEAFDYLLGERTTESAHVAITTASTTLLLARHPVISVNGNVAAICAKEIVELSKVTNALLEVNLFYRDERRERSIEKELIKNGARKVYGVGSRSSARISELQSERRRVDPHGIYVADVVLVPLEDGDRAEALVKMGKKIIAIDLNPLSRTARVAQITIVDNITRALPTMVSIVRQLKCPKDDAIFTKIIKGFNNKENLAHSLKIIRGGTNAAALSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGD1</accession>
    <name>A0A6A8FGD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF488 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000071">
        <property type="protein sequence ID" value="MRN68465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="114" mass="13501" checksum="6FE0CF9641ECC98F" modified="2020-06-17" version="1">MIKIERIYDYPKGSVGFRILVDRFWPRGLSKDKVKVDLWQKDIAPSNSLRVWFGHDEKKWDGFRRRYFNELDKNTESVKTILDKARQGSITLLYGAKEERFNNAVALKEYLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGL5</accession>
    <name>A0A6A8FGL5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FIO04_01600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000052">
        <property type="protein sequence ID" value="MRN68374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MRN68374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="276" mass="30235" checksum="0D2D59BCD95C0F48" modified="2020-06-17" version="1" fragment="single">NVNKEKLGGMIFAIVLIALIGIATQLLVSMCLHLFGLAAAAILTALILKIALAIKGMEKHAIEIINALERGDIKSAQHNLSLIVRRQTKQLSRQDVLSATIECIGESTVDGIVAPLFFYSILGPAGALAYRTINTLDSMVGYKDDYYKNIGCMSAKLDTIANYVPARITSFLMVISSRLLGADWKNSIQILRRDHSKTRSPNAGYPMATMAGALRIKLEKVGHYSLGENREPLSIAKCKIAISIMKLTTILFSLSLSIPMLLILYLVGWWKLLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGQ9</accession>
    <name>A0A6A8FGQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_01895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000063">
        <property type="protein sequence ID" value="MRN68431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="129"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="245"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="479" mass="52477" checksum="2FA3167DFA22480A" modified="2020-06-17" version="1">MQFESMEMTRDEEPVFDELYSLISTISGAKYAETRYHCRIINEVIFSNGEIELIRNVSNSGCGIRVLVDGCWGFTSTSNISKDALKNALYDAMSIAKLLSGNKKKKVEGLAEVNQMARGHLEARVKGNLKNIDIEQKIKTTKDAERAARNYSEKIKSASCIYREILDHKIIVNTDGAEVQLSDSKPEFNVTTIAAEGTETATISEGIGITGGWDDLFAKNDPLDYAILASEKAVKLLKANHVPGESTTIILDPGMVGMIAHEAIGHMVEADFVLSGSLVNDKIGQRVASDLVTLIDSGESKTFPKGAGTIAVDDEGVRAENVIIIENGYLESFLHNRESAFIFDTKPAGNARAYEYDDDPLIRMRNTFLEPKRDTVDDMLKETKHGYLLKGARNGQADANGEFMFAFQEAYLIEKGEIKELMKGASVSGRAFDVLRSVDMVGKDFAYDMGTGYCGKIQPMKVDGGGPHIRCFATVGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGT4</accession>
    <name>A0A6A8FGT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_01960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000067">
        <property type="protein sequence ID" value="MRN68444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="144"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="377" mass="41222" checksum="DE0F0E356769692A" modified="2020-06-17" version="1" fragment="single">VSIPVRLDNKEIRVFTGFRSQHNDARGPYKGGIRYHPQVTIDEVKALSMWMTWKCAIADIPYGGGKGGVICNPKEMSDLELERMTRRYAYAIADIIGPYTDIPAPDVYTGGKEMAWIMDTYSALKGNYVQPEVITGKPLAIGGSLGRTEATGRGLSFTVREAATKLKLNMHTATVAVQGFGNAGQFAAQLLEEQGAKVIAVSDSKGGVYNKNGIQIGALRKHKEKKGSVVGFPESKSITNEEVLVTDCTILIPAALENQITKKNAPKISAKVVAEAANGPTTPEADDILYKNKTLLIPDVLANGGGVTVSYFEWLQNLRRESWSESQVNEMLDKNITRAFSDVYATHDKYQVNMRKASTVLAINRVVDAIKIRGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGU5</accession>
    <name>A0A6A8FGU5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PFL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_04265</name>
        <name evidence="3" type="ORF">FIO04_02010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000056">
        <property type="protein sequence ID" value="MRN40241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000069">
        <property type="protein sequence ID" value="MRN68454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="66" mass="7933" checksum="5C01FF4FB8C55696" modified="2020-06-17" version="1">MMMQELDKEEGDRINMSISRKAYDALATYTRQVNEKNNDIQKKPFTIEEVLDEEIIFLFSDEWKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH35</accession>
    <name>A0A6A8FH35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_08915</name>
        <name evidence="2" type="ORF">FIO03_09100</name>
        <name evidence="3" type="ORF">FIO04_00250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000204">
        <property type="protein sequence ID" value="MRN41148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000447">
        <property type="protein sequence ID" value="MRN62177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN62177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="112" mass="13502" checksum="3387308ED58739FD" modified="2020-06-17" version="1">MFHEKPFNFATLRIGTGIKKLKEGLDPEILAYWYKRIEDKAIESAPSHLKEKIHITQDRILWMKFRVDISKRVVPYVMQVIDEYIPMMPYSTGLYFRRVQQILIQEMNKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH48</accession>
    <name>A0A6A8FH48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_00730</name>
        <name evidence="3" type="ORF">FIO03_01050</name>
        <name evidence="4" type="ORF">FIO04_01090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000005">
        <property type="protein sequence ID" value="MRN39559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000018">
        <property type="protein sequence ID" value="MRN60629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000033">
        <property type="protein sequence ID" value="MRN68276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="97" mass="10750" checksum="3600A21FDCA14FAD" modified="2020-06-17" version="1">MPIAIIPDVDEQRCIGCALCVEICTALGPDVLRVKPVEGWKRGKAFIFYPERCISDGACIGVCPTHAIFWMRPMEYTAGQPVPLHKNGVFDKGWEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH54</accession>
    <name>A0A6A8FH54_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tmk</name>
        <name evidence="4" type="ORF">FIO04_00350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000008">
        <property type="protein sequence ID" value="MRN68132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="209" mass="24092" checksum="C64B7E45B27077DB" modified="2020-06-17" version="1">MFLLMQVRNQLLGKGKIIVIEGADKAGKLTQSRLLIDSLKLSGRICVVMDFPDYTTPIGMEIRAFLDGKREYSNELKHMLLSANRWERKREIESMIETGTIVVINRYYQSNLVYGVSNGLNINWLTNLERGLPREAIVIVLDVSPTVSSQRSEAGDLDSFEKNQKLLLEVNKNYRKLAKQFKWKIINGEKRKEQVHQEIMKIVKLLNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH63</accession>
    <name>A0A6A8FH63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="245" mass="25561" checksum="792D22822E519B3C" modified="2020-06-17" version="1">MKLNNSSVSALAIVLLLISSLAIVANDTILLGQAKKSSTTTKAGNAGVGSGGAGGGFAEQPPIGTEPLTPATANNSAAAIAIAHRLAITSVNSSKSNGGPCLPQLNHFILPLKEARFTVIKQCVTVTGRVVWTNYFNNDGDANFNVVLDPPYKNMLGPGSYSQVFASKYPGGPALHMETVCQGPVTSKSKENVGACDGYNGPDFRSVLPKIGQHVMVTGRYLIEMPEMPGGITELHPVYAIKILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHA7</accession>
    <name>A0A6A8FHA7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_05650</name>
        <name evidence="3" type="ORF">FIO03_05520</name>
        <name evidence="4" type="ORF">FIO04_02915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000088">
        <property type="protein sequence ID" value="MRN40511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000184">
        <property type="protein sequence ID" value="MRN61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000119">
        <property type="protein sequence ID" value="MRN68631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51" evidence="1">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="304" mass="34717" checksum="2E23D045B46D0652" modified="2020-06-17" version="1">MYYTVTYSMAHRRPLLQYFCSECNILLTETDKSIDFIRSSEECPKCGCLLSESLKRALTPQQDNSNPTASLLFPPKFHTASRLRFDIEEIDSILKLGIGECICLVGNHSKILIERLCISALLPESHGGFGSPNVIIIDAGNSSDIYSCVNFARQYGLDIKDILKRIIVSRPFTIYQLANLVTYELPNVVRKFDTKIIIISDILRMFLEDPQVRVGESRRLVKEITTSIRQLSTNTSVIVNLRCDPPSEYSQMLLPSIDKCIQITNCESDNRIFVQVNNRNTSHKKEDCKIIQLQRRDLEIIPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHB0</accession>
    <name>A0A6A8FHB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000183">
        <property type="protein sequence ID" value="MRN68835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="212" mass="23534" checksum="76A5FF8DE0732174" modified="2020-06-17" version="1">MKKENKKTKKSKRIKSSIGGQARIPRGFGTVTPYLIINGAAEAIDFYKNAFGAKKLGVETLPDGKILHARLKIGDSILMMSDEFPGNTASPTSLGNSTVTMHVYSRDVDKLWERAVGAGARIVMPIDNQFWGERYGKLVDPFGHTWSLSMQVSMTRNEREAKRQAAMDMFTQGKHPGKSDQSMTHMLVSPQARTPPVVWPNVQSHSATYHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHD0</accession>
    <name>A0A6A8FHD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO03_05630</name>
        <name evidence="7" type="ORF">FIO04_01560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000191">
        <property type="protein sequence ID" value="MRN61516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000050">
        <property type="protein sequence ID" value="MRN68366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="329" mass="37381" checksum="21224B416A2AC2CB" modified="2020-06-17" version="1">MNEILQLDNVKKYFPIRRSIKDMFRKNNQSYVRAVDGVSLTIEKGKAFVVAGESGSGKTTLARIILRAIEPDSGSIVFDGDDITKYEGSKLKKFRTNVQMIHQDPYTSLDPRMRILDIVMEPLNIHNKSKSKQERIEDVLGSLEEVRLEPATDIAEKFPNMLSGGQRQRVSIARSLVLKPKLILADEPVSMLDVSVRAEILELMKNLKDRLKLSYLYITHDLSTARYIGDEIGIMYAGKIVEAGPIEQVLLNPLHPYTQALLDAISEPEPQNLEKEKIIRIKHGETRDRPHTGCRFIHRCLYSMDICKSDPLLGGEEDNHYVSCFIYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHE2</accession>
    <name>A0A6A8FHE2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_00810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000023">
        <property type="protein sequence ID" value="MRN68222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="57"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="414" mass="47157" checksum="6C142B7E4197606E" modified="2020-06-17" version="1">MNRSLSILAMEFSSPIFRDRSKLSSRYVPAELPHRETQIEQIQYALKGSYSKPDEFPLTVLQIIGPAGIGKTSTVLKFSKLFEEEFRKNRLKLVTGYVNLKLQGGNKYTIYRLLLERVAPELPAQGMSAEEMLRYLLRYLRENKIYVIIILDEIDYLVKISKDSGGIIYDLTRLNEFDPDKPCNVKGVIFIARSTDFYSKLDSAELSTLGRVPMEFTTYSIKQVSDILVSRCSEAFNANAIGSDIIDEVSKFTTSPSVNGDIRFALDLLLYAGNLAESRGTGRVLVDHIRKVHGQIHPSITTPDIEELPKNQILTLLALIRALRTKKRQYVDLKEIRLSASELAEEFKLKKLDVEDHLDDLHAKNIIEIKSLKEIGMHVKSLNELEPMLQRQINRRNDHRSRSDGIGENGDRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHG0</accession>
    <name>A0A6A8FHG0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_07515</name>
        <name evidence="3" type="ORF">FIO04_00915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000308">
        <property type="protein sequence ID" value="MRN61874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="35" mass="4297" checksum="5390F13252830590" modified="2020-06-17" version="1">MQFNLFGKKFKCDNCGKKFKTKIELEQHRQNEHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHJ6</accession>
    <name>A0A6A8FHJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000134">
        <property type="protein sequence ID" value="MRN68684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="56" mass="6509" checksum="258FD0BC9A85D3D9" modified="2020-06-17" version="1">MEIFESVAWVASGFVPTLLLLEVYERMGRRKVLDKKKSRRSSNIISGYQDRDMTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHN2</accession>
    <name>A0A6A8FHN2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB</name>
        <name evidence="12" type="ORF">FIO04_01275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="WJXC01000039">
        <property type="protein sequence ID" value="MRN68312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="390"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN68312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="517" mass="55794" checksum="C529DCCC4C77595A" modified="2020-06-17" version="1" fragment="single">MVEMIGAKALIHALEKEGVDIVFGLPGGANLPIYDALVDANFRHILVRHEQSASHMADGYARIKRKAGVCFATSGPGATNLITGIATAHADSSPMIAVTGQVPLAMIGKDAFQETDIIGVANPCTKYAFQPRSAHEIPETVKKAFYIAESGRPGPVLIDIPKDVQQSSADMNFPELIKVRGYSPVVDADLSQLGKSVEILLNAERPIIMGGGGVILSGAFSELQAVAEILMAPVVTTFKGKGSFPENHPLAMGPIGMHGHAEANKMILEADCILAVGARFSDRSVGRYDEFGRGMSIIHMDVDPAEIGKNKSVDVAVIGDVKSSLRTLLKMLSKVIVKKDQDNPWLRRRKELIDHYAETLKDYPRDLTARKALKKLREILPANSIATTEVGQCQMWASLHFDVISPGTFFSSTGLGTMGFGFPASIGAKAARPVVPVVDIAGDGSFNMTENSLAVSVLDNLPVIVFLMNNYMLGMVAQWQRTFYNRRYSGVHQRNCPDYVKIAQAYGAQGIKAQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHU7</accession>
    <name>A0A6A8FHU7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpmC</name>
        <name evidence="4" type="synonym">rpl29</name>
        <name evidence="5" type="ORF">FIO02_06360</name>
        <name evidence="6" type="ORF">FIO04_04920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000106">
        <property type="protein sequence ID" value="MRN40649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000262">
        <property type="protein sequence ID" value="MRN69025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN40649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="73" mass="8417" checksum="776C292E11E1E4D6" modified="2020-06-17" version="1">MARLRLKTLREMNDPDLTDKLSELNADLAKLRAEGAKGTLKKQTGDIRWIRRDIARIMTILNERGSKKNHDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHV2</accession>
    <name>A0A6A8FHV2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO03_05370</name>
        <name evidence="4" type="ORF">FIO04_03885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000177">
        <property type="protein sequence ID" value="MRN61466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000179">
        <property type="protein sequence ID" value="MRN68821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="224" mass="24637" checksum="CFDBD97CA597C2EE" modified="2020-06-17" version="1">MVDKEKIKCDFCGKSFNSRKQLEQHKQDVHSAANKNNVIIPGKKSFKPSKKVIATIGVGILVVIIVSIGVFSATAPHVPSALTIGGIQCSSFEQLVFHIHSHLDIFVNGKPFTIPAQIGIIPGKCFYWLHTHDESGVIHIESPVSRNYTLGQFFDIWNQKFNNTQLFDNAANGNNTLTVYVNGSKVPSGTNYRDIKLGAHDEIAIVYGTPPSTIPSRYIFAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHV9</accession>
    <name>A0A6A8FHV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000180">
        <property type="protein sequence ID" value="MRN68824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="88" mass="10305" checksum="0C0040C19FB3A6D2" modified="2020-06-17" version="1">MNSGRKEKDLSKKLISLDLDEGIRIEHQSQPKKLFINRNACGNFVAQFIDKEKNQNSEINNIQYFSSDVEVLEYVKSRFNKNFSISLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHY3</accession>
    <name>A0A6A8FHY3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_00535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000013">
        <property type="protein sequence ID" value="MRN68169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="667" mass="75311" checksum="31B8089A495E27B2" modified="2020-06-17" version="1">MARMAAIGLRRDKQVIVSILHDLGAVQLEPLSKDAAAMLSSGREGDPYREVILSDQLLRMRALKAALPSYPVVQRHQFKSIEELLHAAKAIDIDSKVGYLERQKDDLLTRLKDTENNLRLVEEFSFFPEDLRILHLSSAHCYFGRAPSEKFVEFKKALEERKKDVVLYYKEDKAATHFVLVILPNFPTQVLASLVQSHSINLEPVPNLSGKPSNIIQDQRNQKSEISNKLQAIYGQLLEISKKYYATIVSIQEQLEIENKKSEVTDNFGLSADALALEGWAPKSKLKEIRIMFDRHTRNTAVYELKTAERPPTLLANPKKFRVFESFVRFYSMPSGDEFDPTLMFGLLFPVFYGMMLGDVGYGIVILLVSLWVIRRVEGGKRNLNIMPKPLRNFAKTIVRPSQMVKLAKAMIPGAIIAIILGFIFNLYFGFHLNGYLFHYASGLHYLPSSGTFLDPVGTFGLKKLLLLSGYIGLGMVSFGLILGILNNLREGQKRHMIGKVGWLLFGWGIVLTGLALLHHSHINPIRHVQGVVYFGLILGGIGLMFYGEGVRAVMELPSIISHILSYTRIVGILLASVILADVIDFIFIRTLHHTLPYIVLGVMIFFIGHIFNIILGVFEPGIQGARLLYVEFFSKFYHGNGRPFRPFGTRRKFTVEQYNPEVSTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHY9</accession>
    <name>A0A6A8FHY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000282">
        <property type="protein sequence ID" value="MRN69065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="183" mass="21692" checksum="EE61423E715162BA" modified="2020-06-17" version="1" fragment="single">WPVAIDVVKHYRSVNRTITSVEVASAILHDILEDNDRILDSHKTKEYGFEAYLSYRFGNRVQDIATQLKIRPLENFTGANNEERELNRFREYCAILISSEYDVKTIKLADRLNNMKFILGVAQMNKKVIYDKMKRYMREGEDFYLAYTMLQPKLPCFYANIRSTYEKLRSIYFEQTLTMPQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHZ6</accession>
    <name>A0A6A8FHZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrroloquinoline quinone biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000058">
        <property type="protein sequence ID" value="MRN68408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="PTHR12922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="247" mass="28397" checksum="A2FA690BC1FEB1B2" modified="2020-06-17" version="1">MGYMDLMSKVENIELLGGMIKHFATHRGTLDNVFDLEDGFDKTIWMNNCIEKLKKDPDSARMLEERYMGPEYNLDDLIKLPKNSLGYTYAKLMKTMGFEPHFYRSRDRPSLDDLSDYVTMRVRKTHDLYHTISGFNMYIGEVGVIALNVTQYAYPAFMLIDLIAVAAACFPGLAKIPESEKIQSSLVFDTLSKGLKMGREAKSLFPVKFEEMIEMPIEDVRKELKITPIKEGPSWYQYPKLKDEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI05</accession>
    <name>A0A6A8FI05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_00205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000004">
        <property type="protein sequence ID" value="MRN68103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="187"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="391"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="555" mass="62163" checksum="30645CD05BD56C72" modified="2020-06-17" version="1">MKTSDLFLRCLEAEGVEYIFGLPGEENADLMISLLDSSIKFILTRHEQSAAFMADVYGRLTGKVGVCLSTLGPGATNLTTGIANANMDRSRVLAITGQTDSHMLHKESHQNMDVITMFKPITKWNQSIRNADNIPEIVRRAFKIAQEEKAGATHIELPQDVAKQESRIRPIEKPSEVLRSHPNKSLIEKAVRLILEAEKPLVLVGNGCIRGNASFHVRRFVEKTGICSMNTFMGKGVISDRWERHLQTIGIKAADHALIAMKEVDLVIAIGYDLVEYSPRFWNGDITKKIIHMDFTPAEVDTYYPPTVEIAADIELTINAILTELEKEKNQNPNLKCFPCHDVPATFKRIKKELVERVLRYANDPSYPIKPEKLIVDVRRSLDDRDILISDVGAHKLWIAKTYYTYDPNTCLISNGFASMGFALPGAIAAQLAFPERKVVAMCGDGGFLMNVQEIETAVRLKLPVIIVIWCDREFGVIALKQIDEFGKKAFTEFNNPDFVKLASSFGAIGYAVKSTVEFPDILEQAKMSKDIPVIISVDIDYSRNKILLDDNFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI08</accession>
    <name>A0A6A8FI08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">FIO04_02740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000108">
        <property type="protein sequence ID" value="MRN68596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="466" mass="52232" checksum="4B3D51889D3C3E61" modified="2020-06-17" version="1">MATKELNMDYSKYDFKDSTELYVYLSKKGLSRGTVEEISRLKGEPDWMRDFRLRSYDVFMSKPMPNWGGDLSKIDFQNIYYYAKASEKQGKSWDDVPESVRNTFEKLGIPEAERKFLAGVGAQYESETVYHNLREDLQKQGVIFIDTDTALKEQPELMKKHFGKVIPPEDNKFAALNSAVWSGGSFIYVPPRVKIDLPLQAYFRINAENIGQFERTLIIADEGAEVHYIEGCTAPVYTTESLHSAVVELIAKKGAKIRYTTIQNWSKDVYNLVTKRAYAYENATVEWIDGNLGSRLTMKYPGVYMLGKNAHAEVISVAFAGSGQHQDAGAKAVHLAPNTTSRITSKSVSKDSGRTTYRGLLHVAKGATGVKSNVRCDALLLDENSRTDTYPYVEVNEDDATISHEATVGKIGEDQIFYLMSRGFSESDALSLIVGGFMEPFTKELPMEYAVELNKLVKVEMEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI73</accession>
    <name>A0A6A8FI73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000129">
        <property type="protein sequence ID" value="MRN68666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="94" mass="11243" checksum="D29981150DE130A6" modified="2020-06-17" version="1">MSSSYPPPPYHSPESQQAQHPLNDRINEHDQTSVHFDKVGERTSKLEELKRLLNKHYPPQYARHFFVRIAYLTSQGMDDVYRRQRPFQQKSRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI75</accession>
    <name>A0A6A8FI75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000076">
        <property type="protein sequence ID" value="MRN68482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="179" mass="20385" checksum="E94E7690DBDA7891" modified="2020-06-17" version="1">MPSNTSSDNEVKIIQGAYRIEYLMEEVRVSYKRDVNVSVGGLTIDAKEGDLSSLPRWVAKILLDQDTVEIPDNHVSTYISRALNRERIAKPHDLSGIDTDFYIRVNDYLEGLKERERENLIVSMNSFIASRLEKIVKLAAASPLSPELKEKLSAEENELYILVHNSSSTFKQRVLKKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI92</accession>
    <name>A0A6A8FI92_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000032">
        <property type="protein sequence ID" value="MRN68269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="409" mass="46109" checksum="08BC9AE23C151AAB" modified="2020-06-17" version="1" fragment="single">MKISIPEELDRIRSEIRDITSDIIRKVQRRNELSKQIGAIKNKLKIDVKDERVEQDIRTFISKLSNEIGIDPDFAGRLLNILLAESLRLQLTEQHDSTQFESHLAVFMKAKKLESSGKKIIHMEVGEPDYPPPESVRKALSNVFESRQYHYSETKGITKLRTSIAQTIGNHITTDKVIVTPGGRFAVFVAIASLLTAGDELICIEPAWPAYRECAAFVGSTTNILKTTLEEEWNPNIKKLESMINGNTKMIALNYPNNPTGRILNKNIMEKIVSLAKDHRIFVLSDEVYRDYVFTEFTSVLEYGYEKSIVISSFSKGHAMTGFRVGYAIAEENLIDQMAKLQATALTSVAEPMQYAALAAIADSSAENAKRIKRRLEIISDKLREMSLRFVRPDGAMYVYPELGIGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIC0</accession>
    <name>A0A6A8FIC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000243">
        <property type="protein sequence ID" value="MRN68981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="161"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="364"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="589" mass="66401" checksum="42BAE59D8B34BEC3" modified="2020-06-17" version="1" fragment="single">MVSRYRCPACNSFNSVNFNKIFDGRLLFSCSKCKICALVPKHSDADSHDSAYLEFLDLYDNGRIAKSDDLNAIMQQERILRPPSEIKRLLESNNNKKGTKNKLLTEVLYSQQDYVVDYRVIQGPDGKLGSTVDDLPVDDRITSVLSRKGIKRLYTFQEESVNKILRGKNTVIVAPTASGKTEAFCIPILQKISEVIHSSLLPSRQVFGIFVYPTKALSRDQLPKIREFAESLGIHVGIFDGDTPPNERNSILDSGPEIIITNFDVIHYHLWHKTKFSYLLRTSRFLVVDEAHIYTGVFGANVHYIIKRLERLSRNKLQVIAASATLKNASEFCGTLFGREMEVIQGEGRKGKINFVMLFPSLRSHRSLVLDLVKRTTGGGHKTIAFSNSHLGSELLSFYLSRQGIKIKVHRAGLLPSVRKIVEESFKDGKLMAISATPTLELGIDIGDVDAIISSIVPINRLTQRFGRAARRGQEGYALLALGNDPISQYYRSHPDEYLADQEQAYTDPSNPFVQEYQILAMACDKPISKYEFLNENSRKVNNAIQKLVSKDLIKLSSDEKFFVSNIKKAYEKLNEYSIRGIGNKVDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE0</accession>
    <name>A0A6A8FIE0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000349">
        <property type="protein sequence ID" value="MRN69205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="25470" checksum="66350A8A1849C3FE" modified="2020-06-17" version="1" fragment="single">MINLLFGITLGLFSSLLSIKFGARYRCPHDCDISFSRIDTLQNHLQFVHSKKPLNRKRIVIIGGGFGGVTVLNKLQDRFQTDVTVDITMISKDNYLLFTPMLHEIASGMIETRHIVTPIRSFCKRSRFYCAGVESIDLENNSVEIRSSLAPIPHGTLNTMGRNSKSLCYDYLVIAVGSETRFFGMSDVEQNAFTIKTLDDAIRLRNHIIYLLEQADQLLPESSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIG4</accession>
    <name>A0A6A8FIG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000106">
        <property type="protein sequence ID" value="MRN68588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="85" mass="9380" checksum="F62E455DA6115020" modified="2020-06-17" version="1">MTKGKPDPSSLFSAVERLNLKTTEALIVENAPLGVEAANRAGIPCIVVLNNTPLDTTDFKSLISEERILKRTESAFNFLQKWCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIH9</accession>
    <name>A0A6A8FIH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_06035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000370">
        <property type="protein sequence ID" value="MRN69245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="2"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="403" mass="42751" checksum="AEC62CAE0A0B357E" modified="2020-06-17" version="1">MIVAAIMLVITHRLKQPMVIGYILAGMIIGPYTPPFSLIQNVNSLNTFAELGIIMLLFVIGTEFPIAKLRSIGRISIIVALPESIGTLLIVYFVAQALGFSFFDSLFLALAMSITSTVVTVRILEELGMIKDKSTVLILGITIVEDIIAITTLGIFQSVAANSGQVSIPHVSISIGIVAAFIGSILLLGSRYVPKIIDKIGKTGDYALILIVILGLAFGLSFAAKELGLSVATGAFLAGVLVAESKSANIARVITTPLRDMFAAIFFISIGALIDLSHIPLLIVPAMLLILTSFASKFLIICAILVRAKGFDGITTLRTGLGMASARGELSLVVAKAGQDVGAISSSVFPILGVVTIVTTFITPYVIKFGSRIRISPSLTSSSDEKGSSPEKSKKRFRFGFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK0</accession>
    <name>A0A6A8FIK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00270 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000294">
        <property type="protein sequence ID" value="MRN69094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="CHP00270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00270">
        <property type="entry name" value="TIGR00270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="89"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="147" mass="16332" checksum="730992AEA616A170" modified="2020-06-17" version="1">MSSFCELCGRKVIDEKKTVLIDGIALNVCRGCSKRGKPYTPPMSISKTKPTASSNPVARSTASNKSTSTTRKIEMMDNTILNPEFAKLIREARMKKGLTHEQLGAQMNEKANLLKKFETGALKPDELFAKKLQRFLGIHLYVGVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIP0</accession>
    <name>A0A6A8FIP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000004">
        <property type="protein sequence ID" value="MRN68107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="355" mass="41228" checksum="9237A8A62FF0C35E" modified="2020-06-17" version="1">MKRSHPDKHKRSTSKKRNIYHDEQERKQRKERKDTLNYLTLALKDLNYCLNTLKINKDTQVREKINEFFEQAITPEAISTYGERIATMNLIADFYFSSTSRYIFSQPELYDFLTLATQGLPTEQKRARAIERVFMIYRDIMENYQTSNDSLRFNYPKIIVDVIAILHAGEDTSGKRVGVNALDEYYNSRKIKGSSEVTSASAAAVQINPTLTADFPADQFEKDQIQEEQLIETIVQITGRKNKGIRESLAKLHSLDIKKISDLCANYNKIEKYCKLATNSNEFRDELEKELGRKLTDNQVQRATTSIKKVRKYVENLLDGKFVPHGSHGINHIKHNLEYGYQVMDLIEHKRRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ0</accession>
    <name>A0A6A8FIQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000184">
        <property type="protein sequence ID" value="MRN68836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="75" mass="8374" checksum="4B3215C75774B6EB" modified="2020-06-17" version="1">MVFVIQKTQDEAINGGSPNASIANLGLKNGLSMIEDEVRVDDFCRQTVLHKLATSFSYDLPYQKLDKVQSNSDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ4</accession>
    <name>A0A6A8FIQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000060">
        <property type="protein sequence ID" value="MRN68419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="107" mass="12540" checksum="71F34DB461BC7B03" modified="2020-06-17" version="1">MKPNNFAMKDWHLEHVEKVIIRYIKGIPPDASSFEKRNFKKYGTISSCAKQIEYDIKHGVTIEDVLTVMQRIRYDKSFSELRGNPETVQRLDELERQVSAPKKVASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS2</accession>
    <name>A0A6A8FIS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000317">
        <property type="protein sequence ID" value="MRN69141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PQQ_3" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="238" mass="26259" checksum="D78CC87357688951" modified="2020-06-17" version="1" fragment="single">PCLVDDAIIVVGSMNNGIYALEGYSGNVRWKFETGGEVWSSPSYNGNEIFIGSDDGFLYCLDIDGKLQWKTKLNGKIRSSSPCLSFAEGQSPSVYIGTYNGGMFCLNQSTGMIRWSKQIPEPVMASPATIKDKVFFAASDKRIYCFQVKDGSRIWDFETGDKIWSSPSLSEYAGVMFFGSLDSHIYGIDINTGRQTWKFPTMSIVDSSAAIASNMMLIGSRDGLLYVFGSETTPSYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIT1</accession>
    <name>A0A6A8FIT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type 2 isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="1">5.3.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000325">
        <property type="protein sequence ID" value="MRN69161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="70" mass="8004" checksum="2607EFF318A1E8F8" modified="2020-06-17" version="1" fragment="single">MSNASDMPPDLEIIKRRKKEGIDIPLHKDVQAKTTSTYLEDIKFVHNALPELDYEEIDTSTNFLGHKFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIT4</accession>
    <name>A0A6A8FIT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000143">
        <property type="protein sequence ID" value="MRN68708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="113"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="335" mass="38547" checksum="FF14DC0526456A7C" modified="2020-06-17" version="1">MSIELKKLLQTTLWFLRRNDWDIINYYNFLAPYFLRATGNNMLNFGYWTDNTQNLTEAQNELCRLVGKVAELDVAKNLADIGSGFSEPAILWKSVHTSLNIICVNINFLQQKVTSELMRQGSNNNIVNSKISQQSLLSSSLDNTNTNSIEIISLVNATAKILPFRDKCMDRIIALESAQHFKPLVQFIQESRRILEYRGLLVIAIPVLKLSSYYSLLTPTIQEVMNLGILSLMWASEHYELKNIESMINKVGFEIIDIHWIGSHVYEPLANYYLQNRRMIKNIMLKDGSSSLLSSYFLNFSYDLFEKIVYKSALKLKVAYQEGIIDYVLIKARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIT8</accession>
    <name>A0A6A8FIT8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000146">
        <property type="protein sequence ID" value="MRN68718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="132" mass="15115" checksum="8B2825CAB14782CF" modified="2020-06-17" version="1" fragment="single">MPQEVTTEQIFTVLSDNTSVNLMKTAYAGRLTSSNYVGKLSKKQFYTKLKRLCNTGLVEKRENTYYRTTTLGSLVYNGHVKTLEDALTNFWQLKAIDILKTREDFPADRKESIIDEIVKGSNLKNFINSTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV6</accession>
    <name>A0A6A8FIV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hsp20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000348">
        <property type="protein sequence ID" value="MRN69204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="207" mass="23906" checksum="DBEB77F270E87175" modified="2020-06-17" version="1">MCNCDIDSYDWFRRFNSRCFGAEFFRDFEEAEREFEDAFMEIETKASKELMSEYETSEGVKVREIGSFVYGYSMAIGFDGTPRVREFSNAPSGIGSSRSSRGRKGGVSNYNRTEIMSEREPLADINVYDKEVKVVVEMPGLSKEHIKIQAYNNSVEVSTDYPQRKYQVIDIPPDADIETVKSTYKNGILEIVFKKKRKLKRNNKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY4</accession>
    <name>A0A6A8FIY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000064">
        <property type="protein sequence ID" value="MRN68433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="12375" checksum="7C091AA5DB92C5CA" modified="2020-06-17" version="1">MTTTENKFKEAYKQAVEEALSILGKNVSVIINSYILEKYSIRLTDTGDNPKLLSDALEAVIDGGSRIVQRRILRLLYNRIGVELPFAMTTNFEDKILTAKKEYEKASFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ6</accession>
    <name>A0A6A8FIZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prohibitin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000477">
        <property type="protein sequence ID" value="MRN69415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PTHR23222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="282" mass="30878" checksum="4D7512DD6813B7DB" modified="2020-06-17" version="1">MIQNKLKILASVVTFVVIVIVLFESVVVVEAGHRGVVLYVGAVENRVFGEGLHFIIPFVEKVIQLEVRTLKFQADASAASNDLQEVHTTIALNYHISPNQANIIYQQLGADYSNKIIATTIQESVKASVAKFNAEELITKRATAKAVVAEAIANTLSARDIVVETVFITDFKFSQAFANQVEAKVVAFQSFLTEQNKLKAIQVVANQTVVQALAAARSNVAKATGESQAIQIITEELKQSPEYLKWLTINRWNGIMPYALGSGGSPFFQLPVTTIAQNQTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ37</accession>
    <name>A0A6A8FJ37_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_01310</name>
        <name evidence="3" type="ORF">FIO03_03740</name>
        <name evidence="4" type="ORF">FIO04_02500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000010">
        <property type="protein sequence ID" value="MRN39673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000104">
        <property type="protein sequence ID" value="MRN61153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000094">
        <property type="protein sequence ID" value="MRN68549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="96" mass="11295" checksum="96F919527F92CBC8" modified="2020-06-17" version="1">MKYRDRNEITAQILESANGNRVRLTKIMYDGYLSHTVTKEYLVLLIEKGLIEYLDGERTFKTTEKGMNFLRIHHRVQKLTPVAPTLHSREEKVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ66</accession>
    <name>A0A6A8FJ66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000103">
        <property type="protein sequence ID" value="MRN68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="149" mass="15405" checksum="3F6FFA7CAD9E96CB" modified="2020-06-17" version="1">MAKFETWVALGSLALGVMFVALIISFYNFLIGPEGKGPQVFVDPIGVLVLIVSIAGVPCLILAGAVLGLSRSSAGRTSALILIITGIILIAGMSGARIAFTHINSLFVVPGMELVPLIFIVGGIGVGAVGGYLLNASNKARRNLEDEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ89</accession>
    <name>A0A6A8FJ89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_02755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000109">
        <property type="protein sequence ID" value="MRN68599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="94"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="378"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="547" mass="61369" checksum="1A62F21FCB2FF7BE" modified="2020-06-17" version="1">MYILGINGGVRSGNQDASACLLRDGKLIAAAEEERFLRIKFANGVLPKNAIRFCLEFADISIHDVSYVVYPAITYSNIENILETYFRFHFGYCPKIKLVDHHMAHAASVFYTSGFDESMIITADLTGEGKSTTLCYGADDKISVLKEFRVPDSLGFFYSMVTQYLGFQRDSDEYKVMGLSAYGTSNAVKNYDFSWLLSLKYNNGGTGGDYSLNSDCLSLNENSRTPPRQEPLYSEKFLAKLNKPRRLADVPIDGYYKDIAKSAQVHLEKVALFLLKYLYDKTSSTNLCLAGGVALNVLMNQKLLESGFVNNIHLTSVPGDNGLSLGAAILVAKEYGFQIDKYEHPFWGPEYTNEQIEYVLARAKVPFKRMKDISKEVAHLVAQGKIIGWFQGRMELGARALGSRSILSDPRDKTMKDRLNKHIKFREDFRPFAPSVLEERAPEYFMNCRYAPFMAITYNVRPDKVKEIPTPTHVDNTARIQTVAKGQNGLYYDLISNFEMETGVPVITNTSLNVMNQPICLSPVDALSTFYSTGMDGIAIGDFLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA7</accession>
    <name>A0A6A8FJA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_07505</name>
        <name evidence="3" type="ORF">FIO03_10005</name>
        <name evidence="4" type="ORF">FIO04_07435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000144">
        <property type="protein sequence ID" value="MRN40871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000560">
        <property type="protein sequence ID" value="MRN62355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000543">
        <property type="protein sequence ID" value="MRN69515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN62355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="185" mass="20780" checksum="FDC2972406BBC563" modified="2020-06-17" version="1">MRHSSLEIDERRSRKLLLGIFYFCAFAMASITAYALYVSVGEYLKTGRVVIGEVLVNTEFPVHGFSKLVTYLMIVSVVGWYCVTKLGGEKVTDVPRTVKLILQLVVLAIAVIALYEFIYNFIIWSSLITADAMKGILKLDAINMPYPNPKTPWNLVFATKMSLAAFLISAHGFYIMSRPKKIPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF0</accession>
    <name>A0A6A8FJF0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Biotin synthase</fullName>
            <ecNumber evidence="3 12">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">bioB</name>
        <name evidence="15" type="ORF">FIO04_06640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="WJXC01000439">
        <property type="protein sequence ID" value="MRN69361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 12 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="51"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MRN69361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="323" mass="35422" checksum="6E8101C255A37D11" modified="2020-06-17" version="1">MQNHDFIHDKTDNVLAGLAVSFEEAERLLFTKDIGTLAQCANTITRAFNANKVDVEMLLNAKSGTCPENCSFCSQSSFYDSRINKYPLLPTEVILQRAQIAKEGGASSFCLVCAYRAPPEKDFQQICKTIVEIKNKVDIDINVSLGFMTHARAGKLKSLGVKRYNHNLEAAESYFSKICKTHDFADRMKTAQIVKDEGLELCCGGIIGMGETPQQRLELGFSIASLRPEEVPVNILVAQQGTPLAQIPQIAGDDAIRTIAVWRFLMPKTILKIAGGRELHLKDNGRLALRAGANGLITGGYLTVGGNTPDKDLQMIHEIGLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF1</accession>
    <name>A0A6A8FJF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000469">
        <property type="protein sequence ID" value="MRN69404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="280" mass="31967" checksum="578B4A4A6007AE5A" modified="2020-06-17" version="1" fragment="single">MRIAVVGAGVSGSYLGHMLHKGGHDVEIFESSRKENQWAVCAWGASRNMLVKFSNRAGLDFDNYIFHVGKTLKMDLPNHVREFLDLRGLVTYNKQKWEHDLLKDLKITYGFKCTQQNFPFNEYDYVIDCTGMHRSLLPRSDEDFLIPAYEYLVENVQGMDEFYVIGYKGARGYFWYFPLDNNRGYVGAGDIDKKYAGVEEFLSEHPEARVARKIGRPIRLAPPRRMEPFCAGNVIGVGESIGCVFPILGEGIIPSLICCDIFLQVLNGSKQKGFDFEQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG1</accession>
    <name>A0A6A8FJG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aliphatic sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000014">
        <property type="protein sequence ID" value="MRN68170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="367" mass="39336" checksum="815F66697AEAE043" modified="2020-06-17" version="1">MDKKVVKKLTIGALVIILAAVMVHTPVTGFVHAQSATKVLRIGYFPNINHAQAVIGFGSGEFQKELGSSIQVQPYIFNAGSSAIQALLANRIDVTYVGPGPAVNGYVAAQGADLRIISGAASGGAVFVVRNDSGIKSPKDFANKVFASPQLGNTQDISLRKYLQDNGYKTKDNGGNVTVTPVDNPIILTLFLKKQIDGAWVPEPWGARLVNEAGGRILVDETALWPPDGKFVTANIVARTNYLQQNPDVVKKLLAANVNETLWINNHTSAAIKSFNTEFQKLTGKTIKENELKQAWSRIQFTYDPLKLSLFQGANNAYDIGFLAKGKPRPDLSGIYDLTILNQVLKEKGLQPIGAAGGAGGLAEAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG7</accession>
    <name>A0A6A8FJG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000231">
        <property type="protein sequence ID" value="MRN68952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031737">
        <property type="entry name" value="CNDH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16858">
        <property type="entry name" value="CNDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNDH2_C" evidence="1">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="223" mass="25659" checksum="DE0C16FA4774E93A" modified="2020-06-17" version="1">MNYDSKKKIAEPPLNLLFNPSLVSKKDVWDIDISKLLGLLLNIIHASGKKDLRLCGIAALSSSMIHRLKVESIFRLEKVAMQKKTIIDPVSHDPVTDLNAIELPFRFESTYPVSLEELLQVLENMIFEISNPDSRRKKLTIEPVQGFDFDQYSQKFEQIIRQYEDKIFGIVNVDHVVMFRMLISKMGALEVARYFIALLYLVTKGKINLEQSEDSEDIKITIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH8</accession>
    <name>A0A6A8FJH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobalt-precorrin-5B (C(1))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_04605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000234">
        <property type="protein sequence ID" value="MRN68962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="352" mass="38167" checksum="AD876E073ADB3332" modified="2020-06-17" version="1" fragment="single">TKAALIALLSQKTVNDVSVSLPKGKTMNIRIAWTNTTKEQYSATAAVVKDAGDDPDVTDRAEVCSTVFLTNEVGIVSIDGGNGVGRITKPGLGIDIGKPAINLSPIKMIERAVSEVAAERLKDHGVKVVISVPMGEEIAKKTDNPRLGIIGGISILGTTGIVFPYSTASFAAAIRQALDVARAMGDERVVLTTGGRSEDFAKDLFGKNLPEHCFIQMGDFAGYSIRHCALKQIRKATIAGFVGKLTKMSMGIKQTHVRGSHVDMEFMAHVASECFPRIPMSILEEIRNANTARHVSEIITAYRITGFFDLICKKVYEHMREYSKGELELEVIMFDFDGKVSGQFPGGPSYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL0</accession>
    <name>A0A6A8FJL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-keto acid decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_07170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000506">
        <property type="protein sequence ID" value="MRN69464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="153" mass="16786" checksum="816F022B47DFBD4D" modified="2020-06-17" version="1" fragment="single">MENTHTVSSYLIQKLYEYGIKHIFGVPGDYILGFYDELIRSNMLKVINTCDEQGAAFAADAYARVKGFGAVCITYCVGGLKVVNATAQAYAEKSPVAVISGAPGTKERTKNPLLHHVVREYDTQQKIFEHITVASTVLNDPSTARAEIDRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL5</accession>
    <name>A0A6A8FJL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF814 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000254">
        <property type="protein sequence ID" value="MRN69008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="448"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="683" mass="76228" checksum="2D3519202F0E52F7" modified="2020-06-17" version="1">MELSGIELRYLISEINSKITSEYYVSNIVAVTRDSFLFRMHHSTEPDITLMLSVRGIWLTRFKFKQVEESDLIGIIRPEVERAKIEAIQQSGSERIITIRFKHFDGKSRVIVAELFGVGNFILCDEKMQILAILNPIQVRHRVLKRGHQYLPPPTRGTDVLDITLEQLQIMRNSTDTKDLDVLRWLGRNISIPKKFVEEIVRRAGITAPNIGQLSDDDMSRIYTVIKELVADISTGSHEALVILGDDGKARDAVAIPTTNIPSLKPIPTTSMRTAHSYMEAVDEVLANEITERHSNSKTTDIDKRIAILQHDLAEQNKAKEEVISKATVIRKIANDLMAISLGGINNNFDDDSLKEFLGSNSVLIIIEKGRKYLEVLGERVPTADSSLAKISSLLFGRAKELERGCISIEDAKAKLQTQLGNLRNQTTAIQDKIVIKEQIAKEWYERYRWFITSEGLLAIGGRDASSNSAIIRKHLTEEDIVFHAEVHGSPFFILKDAKQVSEISASRMEVAQATVSFSRAWKDGLSSADAYWVEPSQIKRGAPTGQFLPRGSFVIEGRRNYIKGIEIKLSVGLIRSYSHYVLACGPTNAIKKRSVVYSQLLPGGMDPNSVAKKIKTDLVKAAYTNPNAKDDTNAQLADFTKSISIGDFIRAIPTGHSKIFLTEKGEGEKSSLAKPKIDEQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM2</accession>
    <name>A0A6A8FJM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000512">
        <property type="protein sequence ID" value="MRN69474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="204" mass="23491" checksum="7EDAF7915F12BA8F" modified="2020-06-17" version="1">MRNTLPEDIPKIVKLQQESFPYLARYGNVWHPSELQSHIRLFPEGQFCAELNGVVVASASSLIVFLEPEYKEHTWKDITADGTITNHDPKGDSLYGADISTHPKVRHEGIGKMLYDARKDLVKRLNLRRMISGGRLFNYCEHASMSPLEFAEKVIKGELHDPVLSFELDNEFKFVKILPNYLEDVRSLNNASFIEWLNPEYQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ2</accession>
    <name>A0A6A8FJQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_07380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000534">
        <property type="protein sequence ID" value="MRN69504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="7">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="132"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="363" mass="37002" checksum="47DFA48E25DE2F5A" modified="2020-06-17" version="1" fragment="single">MSNLKSAEKLANQEKHFAQSKLRQVLAETIPHQYIVVLKNGVTESAQSIAQQAVSRGGIVPFVYNNAIKGFAIKIASKLVLNSILSNPSVDFVEPDIKVQAFSQVASTGYSRVGGPLSILNGSHPRAVNAGIAIIDTGIDFTHPELNVYKQVSFVPGTSTANDDNGHGTAVAGIVAAEGNVGAVGIAPGARLWAIKVLDKSGTGSMSSIIEGIDYVTQNAGQIDAANLSFGCKCNSSALDTAINNSVAAGVTFVVAAGNAGEDASLWSPASNPNVISVAAMADSDGKCGGLGPQTPYGPDDSLASFSNYGSKVTIAAPGVNIHTTYLGSSYATLSGTSVAAPFVTGAAALYHSLHPTASPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS3</accession>
    <name>A0A6A8FJS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tfb</name>
        <name evidence="1" type="ORF">FIO04_07480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000551">
        <property type="protein sequence ID" value="MRN69524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="105" mass="11543" checksum="3DBFDA5DE5C398DB" modified="2020-06-17" version="1" fragment="single">MPFSLARSDMGLSTIIGRTSKDASGTKINPSMLSTIQRLRTWDSRTQVYTSTDKNLTQAFNELDTLKDKLGLPGAVIEKTAYIYRKAQENRFVLGTSISAVLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS8</accession>
    <name>A0A6A8FJS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000332">
        <property type="protein sequence ID" value="MRN69176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="107"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="370" mass="40906" checksum="DCD8480192EEEF77" modified="2020-06-17" version="1" fragment="single">VNMLNKSSLNSKVLQSGSVFLVILLATSLLSTSYIQNSKALVQEDHEDYGYLKFASYAVKQAYAAKQNNTVNSTIHIPAIAMGPQIPAKGYLVQEIRDHLYWVTDGAYNTMFLVSNQGVIVVDAPFTIGKNYLKAIAEVTKEPVKIVIYSHAHMDHIGAASMFPANATYIAQQETATILKDHNDTSVPAPTVTFSTSYAVRLGNQTLVLDYKGVNHERGNIFIYAPTQRVLMLVDVVFPGWVPFRDLAIAEDVPGFIKAHEQALSYPFDTLVAGHLTRLGTRQDVVTQMEFVKDLKSSAINATKMFANFTKIAEQVGGFSNPWLVFKTHDDDVANQCTQTMLAKWNNRLGGANQYMSSHCAKMAESLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJT0</accession>
    <name>A0A6A8FJT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000152">
        <property type="protein sequence ID" value="MRN68733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="119" mass="13216" checksum="15F28F6321AFB16C" modified="2020-06-17" version="1">MSAAIPPEIEVKEHPNFRTINVGGVYGMPVGMRFEVVLYSEQLEVARALSSVQTPMPPSVSRILECRLIIDPFQAKSIAQWLTAQVNAFEKQFGHIPSAEELQEKATGTEAENKKGLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJT5</accession>
    <name>A0A6A8FJT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-CASP ribonuclease aCPSF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000173">
        <property type="protein sequence ID" value="MRN68799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="93"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="321"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="535" mass="59101" checksum="F8C0590D61414808" modified="2020-06-17" version="1" fragment="single">GWVAHTRLSPHIPSAILNTIHSTLKSSAKERIIFLQELGNRIFRTPLAEGNNGSGNNQLNAAAESYSRGGQTQSWSMNKEVMLFCLGGVKQVGRSCFIVVTPESKVMLDCGINPGESRGLDAYPRLDWFNFSLSDLDAVVISHAHIDHQGFLPSLYKYGYSGPIYCTEPTLPLMTLLQMDSIKISKSNGTYLTYEGRDVNEAIKHCITLPYGKPTDISPDITITLNNAGHIMGSATVHLNISGAHNILYSGDYKYAKTQLLDSALSIYPRVETLITESTYGSSTDIMPDQSVVYATFTQSINKTLTEGGKVLIPVPAVGRAQEIMLVIDKEMRQGRLIESPIYIEGMISEASAIHMSYAHYLGYDVRRSVSQGINPFESEDFTQVNGLSRRDELLNDESPAIIMATSGMLEGGPSVEYFKEIAPSPKNKIVFVSYQINGTLGRRVIDGTMTEVSMLDKSGKVKVVPVRCQTHKIDGFSGHSDFNQILNFVSRIKPKRVLVNHGEKSKSENIASAVYHRLKIRSSVPDNREIIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJT7</accession>
    <name>A0A6A8FJT7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein L8e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl7ae</name>
        <name evidence="10" type="ORF">FIO02_04850</name>
        <name evidence="11" type="ORF">FIO04_05160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000068">
        <property type="protein sequence ID" value="MRN40354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000285">
        <property type="protein sequence ID" value="MRN69072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_L7Ae_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="9">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN40354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN69072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="125" mass="13480" checksum="97EB64F7305EAF91" modified="2020-06-17" version="1">MSKPYYVKFETPKDLVSAVYEAVRIAKQSGRVRKGTNETTKAIERGTSRLVVIAEDVEPPEVVAHLPILCEERNAAYIFVPSKQQLGASLGIDVGSAAATILDAGEGQHILEQVVSSITSIKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU9</accession>
    <name>A0A6A8FJU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000176">
        <property type="protein sequence ID" value="MRN68809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="152" mass="17189" checksum="34CCAC56882EE9EE" modified="2020-06-17" version="1">MNKNRLKEYLLFNRNILIAFTAAFLTSAGTSQAIAKFTSPLFNSLISLVADVSVFLTIFGILFYLDNKHRFVNEQTQARDSSRVKWALIKLASTLSVAEIEYNTVKPAIHFWLLTLHYQPFVASTIASFITIIGYLAVADSMAYLTRLFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV4</accession>
    <name>A0A6A8FJV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_05340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000300">
        <property type="protein sequence ID" value="MRN69108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_2" evidence="5">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="202" mass="23200" checksum="3460A8E743F7064C" modified="2020-06-17" version="1" fragment="single">GNIGTIQDALIRWGPKSIRIYSVSVHYSKPLDYSEKLLNESKHKWRQIETCACELRFAIGNQGYLTEVEQLSDETLKAFESAMEDDLNTSLAFSVFLKFVTELNRYAAEEKLTADMSKIAGVVFNNIMNVLGLRVIEANDIEKKEIESLISMRDQLREQKKFYESDAIRKKLVDEYSVELIDHKKRTIWGIVEGASRLHSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJW3</accession>
    <name>A0A6A8FJW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000082">
        <property type="protein sequence ID" value="MRN68507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="63" mass="7359" checksum="2F0D2DA80B7DD8D5" modified="2020-06-17" version="1">MTNKNENSNADDEGELDPKKEEPRAIKIAKELQKEQRESEQLHVDPEQVLEELEKRQPQSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJX7</accession>
    <name>A0A6A8FJX7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000302">
        <property type="protein sequence ID" value="MRN69112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="147"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="518" mass="59612" checksum="5294202258CF28C4" modified="2020-06-17" version="1">MLEDKLRFLIERGLLRKKHPQWIFKSDLISLGEEIQYKLELTMEELRGPLYAALVQQSSALTLMYCAELIESQGSPSLKAFLNRIEKDGGKAHQLLLNDNRIKEIQTLINSLKIEHPKTIYLVELLKQRYSLFQSINKRQHEQDNFTFKKATDLTNERPKALVFTHYRDTAKKVVEILTENGIKAARFVGQAKRELDVGMSQEEQSAVLESFRNGEFDVLVATSIAEEGLDIPEVDLVVFYEPIPSEIRYIQRRGRTGRKSSGCVTILAAKDTIDERYLYASKRRMEKMKQILSSINPTLKPIQRTDVLANPMTADEVSYFESRRIVLDDRVDKMLSPHLETIKVDDLLPPPQSTNQSIRMKDKKRMELLSLESHTLTNGFRREIDSAARRIHTLIAKSGRQPLDVDIIQQSLSLENSVLLEALKKLEKLKRIEWVDDSRVILSENLAKIPGSTYDVYVEKIIHGRALVIVNGKWHARLNHYDYEGPRELLRKGSEFRAVGEVYRDDGVCSLRVKQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJZ2</accession>
    <name>A0A6A8FJZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="10" type="ORF">FIO03_03685</name>
        <name evidence="11" type="ORF">FIO04_03795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="WJXD01000102">
        <property type="protein sequence ID" value="MRN61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000174">
        <property type="protein sequence ID" value="MRN68803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5034711601" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034711602" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="193" mass="20726" checksum="13CD12BAF2B4BAC5" modified="2020-06-17" version="1">MPGATAVGISFDNGVVLASEKRVSYGNFVVNKNTKKTFPVTDKVGAACAGMIADMQILVRQVGALAKIRKLETRRSVPPNSIAKMMSVIMFERRFFPLLTQVIVGGIDNKPQIYTLDPLGSVLPDEYAAVGSGAEMALGVMDGEFRANMSEQSAKELAIKAIKSSIQRDSASGDGIDVLSMTQNHQEEESLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK08</accession>
    <name>A0A6A8FK08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000093">
        <property type="protein sequence ID" value="MRN68547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="450" mass="50150" checksum="78A12851A16518F8" modified="2020-06-17" version="1">METSQKNNDLRAFLRLLEKENDLIIIKKCIEPKFEIAAIASKLVGGQAILFETVKHSRIRVACNILGSRRRFSLAIGAKTEELIHSYVTAAMTRTTEPKKIFTKAPFEENSSNNLGDLPIVTHFEKDAGAYITSSVVFAKDQERGNQNASTHRLLLLDDRHLAIRMVEGRHLHKCFSFAKEHGQDLKVSIVIGVHPAISIASAYQAAYGANEMFIANSLLHGKLTVTRSNYSQLFIPTLSEIVLEGTILTDRTEEEWMVEALRTYDIKRRQPVFELDRIKFRNNAILHDILPGYPEHRLLMGLPVEAKIFEGVKNVVPTAMAVHLTEGGCTWLNAVIQIRKRLEGEPKNALLAAFASHPSLKMGIVVDEDIDPADPIAVEYAICTRCQADKGFVIVTNAKGSSLDPSSDQQNLLTTKVGIDATATLLKPKERFEVARIPGEEKIKLSDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK46</accession>
    <name>A0A6A8FK46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000344">
        <property type="protein sequence ID" value="MRN69198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="108" mass="11650" checksum="1FE2F232587F49C7" modified="2020-06-17" version="1">MSYAPDSNSDTPLFSGLSGKKMALLVGIIIAGGFFGIQAMFGFPIKDLIRKDVTNEVKVITKAEGTCVVEASDHQPRGIPHCPYNVGDRLIVTFRQGTAPIEKAQLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK57</accession>
    <name>A0A6A8FK57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_04340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000212">
        <property type="protein sequence ID" value="MRN68909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="264"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="523" mass="57397" checksum="6129F0D8A54028C5" modified="2020-06-17" version="1">MKSITCRFGNLIANQNVDFDLARGEIHALLGENGAGKTTLMSILYGLYRPETGEIYVRGERANIKSPLDAMNHGIAMVHQHFLLTPPHTVTENIIVGLKSRKRIFLDTSNAEKKIVELSKKYGLKVDPSAIVGNLSVGEQQRVEIIKALYRDIDILILDEPTSMLTPQEEESLFAALQSMVDQGLSIIFITHKLREVMAVSSRVTVLKNGILMGTVKTSDTNESDLARMMVGRSVVQQISGQRGGGGTESEVVAAQAKKSQAVLEIKNVSALNNSKILFLKDLSLELRKGEILGIAGVDGNGQSELAEVIAGLRKIQGGQIIMDGRAITNLSPREIREWGLAYIPEDRLNTGLILEYTIAQNLILDRWYKAPYSGKLFLNEQEMRKFAEKVIADFDVRTTGLEAQVRSMSGGNLQKVVLGRELSRNPKVLIAHNPTRGLDIGATEYIHKQLIKQRDSGVGVLLLSLDLDEVMSISDRIAVIYEGKIMAVTDKENADVHTIGLLMGGNVGKTGFQKTSGIVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK86</accession>
    <name>A0A6A8FK86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000226">
        <property type="protein sequence ID" value="MRN68939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="169" mass="18967" checksum="A89000481942195C" modified="2020-06-17" version="1" fragment="single">SMACGLPYAIAAQIAYPERQCVAFVGDGGFMMLMAEFSTAVQYKLPIKVIVLKNNTLGMIRWEQMGFLGNPEYGVEFTPIDFAGFAKNCGGNGYSIKKLDEVQQVMRTAMHDKEKKPTLIEAYVDPFEPIMPPKAKPEFLEKMSKAFESGQPYAQRIGLTLYRNKFEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK88</accession>
    <name>A0A6A8FK88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000214">
        <property type="protein sequence ID" value="MRN68913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="227"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="464" mass="52428" checksum="9F645FA2AFE05347" modified="2020-06-17" version="1">MTGMAPFNKPSNINPNTKKFVYFAAENLGNKHQTLREEKNAANDLLDKMLKVIGREVLREKTPTIQDLERSLQDISAQQQHEQRDSTGNKETRGQETDIKGNGIPVSGTPIVAQLMQKGYLKDSNKWLTSKGFLNIGGKILSDVMKALKTGDLGVHETTSLGRGGIVLDSTRSYERGDDIRLVNVPKSLLNSVRRLAKNSSSLKIPLDVEEDDLEEYETLQDVRAAVVYCIDLSSTMRYSSMFGDMSRIEAAKRALWSLFLLNQKFFPSDSISIVGFGALASKVAPNDIPYLKTFEPGSDFLHYTNYQSAFRLASKILQKDGALNKRIVLITDGHPSACFIDDKKEQNKILSQRPYSHFYIPGKEALDFDLDFAAGQLVYLCYRYRQVDQYIGEKTILEAKKCHMMGIEIDTVMISEEDSLLRYVNEMERYVKGRSYYINPTTIDKVLLTDYLNNKKLTIGSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK93</accession>
    <name>A0A6A8FK93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_07490</name>
        <name evidence="2" type="ORF">FIO04_02095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000143">
        <property type="protein sequence ID" value="MRN40868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000072">
        <property type="protein sequence ID" value="MRN68470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="PTHR36934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="137" mass="15512" checksum="1DE78906E676D03D" modified="2020-06-17" version="1">MNFAVKVGSTKERTIRISSAQTTSFLWEGENVLSTPSMISEMEETCRLLLKEQFIHLRDWDSVGTLVNIRHLAATPVGASVVFRAKVVSADVRRVLFDVEASDNLERIGDGKHERFIINVTSFRDKFSSKQKQLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKA7</accession>
    <name>A0A6A8FKA7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000223">
        <property type="protein sequence ID" value="MRN68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="404"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="621" mass="70324" checksum="804B585907760F03" modified="2020-06-17" version="1" fragment="single">KELIKIVDELRHLDAIKGNFMISEEEYLAPVNLDEEGKIASQLIYSNVDEIVEQQNYIFETLWNKAIPSEQRITEIEENKTVPRTEVLYGAENAVGRGVQFMKNTKEKMDIFFDSKAPSIVIEIDAYRNGYMNIRKGGGKIRAFTEITKDNIHYCKELIKIVDELRHLDGIKGGIAVNETEYMATTVLQEAKPLTQVIYSNVKEVVDQGQYIFDIFWYRAIPAEQKIREIEHGIEPSRIEVIPDTKVSISRSLDLIKSAVKEVLVIFATSETFSLAMNMGILQLYKEVTQNGAKIRLLIPDSQQSQWIVNELKSVVPQVGVRIADKSLQTRITILVVDKTELMIWELKDDSLEDPYEAGGVATYSNNKSIASSYASIFENLWKQTELYQKLKEADKIKDEFINVAAHELRTPIQPILGLADVLRSKQRHGKQEKEYLDVIIRNAKRLQRLSEDILDITKIESKSLGLKKELFNLSEVILNAIADFNNQIVKENKDHRLKLRLVAPEEDIFIEADKGRINQVISNLLSNAIKFTKEGSINLAVEKKDNNQEILVSIQDTGTGIHPEILPRLFTKFATKSEIGTGLGLFISKSIVEAHGGKIWAENNPGGNGTTFTFSLPLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKB1</accession>
    <name>A0A6A8FKB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000429">
        <property type="protein sequence ID" value="MRN69346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="288" mass="32640" checksum="2CCE9AA4AF8CB9A5" modified="2020-06-17" version="1" fragment="single">MNKKGMNKSDLITPPIRSRKVAVITACVVIFLVVVDLLMTRQIVPYNNTSETVMFILTVVVAYGVGSWILLGYTKQAISGLRAKSHFINIMYWAVTIIQFCLLAILVFVIFNNSSRYPVLSVYLISSISALIIIGIISFKFFSWYSRGKRNVMVLFFGIATATFGFSILEDAYTKLILVQVVEEKSPPGAIPQSSFLYITDKKYHAEIQYKVVNSHTTTLWILPSSLTSLKNSLDYLTVFPYLFTWLAVATLLRQYYQTIRIGKLPLKFWIILSIPMAFYLIGSGLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKB8</accession>
    <name>A0A6A8FKB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_03020</name>
        <name evidence="3" type="ORF">FIO03_04475</name>
        <name evidence="4" type="ORF">FIO04_06200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000033">
        <property type="protein sequence ID" value="MRN40000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000133">
        <property type="protein sequence ID" value="MRN61295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000386">
        <property type="protein sequence ID" value="MRN69278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PpiC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="93" mass="10200" checksum="A98B4DA2AA176607" modified="2020-06-17" version="1">MADKIKCSHILVKKQSEAIAILDRLSKGEGFANLARELSIDKGSAKRGGDLGSFGRGMMVKTFEESAFKLKKGEITQEPVKTEFGYHIIKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKN6</accession>
    <name>A0A6A8FKN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000292">
        <property type="protein sequence ID" value="MRN69089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="99" mass="11637" checksum="7481F0AA37988B44" modified="2020-06-17" version="1">MSKGVAGISRKEVTFEKPEQFFLIKTDGKNYELFRVCNDTSEVILFSQIFDLEHPPGTGYDLIITSREPSRVKTYFSKQVKKVRQREWIRKTSVTDERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKP6</accession>
    <name>A0A6A8FKP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000116">
        <property type="protein sequence ID" value="MRN68620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="167" mass="18014" checksum="C3998C5599A175B4" modified="2020-06-17" version="1">MALGMIAFLIAYSAGAAVHMGKQQTADLRQHFAEQIKGIDQNGIFINNAKIALGMFVPAAGIGLGVISGFYTGMIFTAIAQTSTLNNVPPLIILITPFGIMEVFAYGIAISRSGIFIYQLVKKKPWREYAIPILIEVGIVILVLLVGAVIEWQIITQFSGPHTLPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKV6</accession>
    <name>A0A6A8FKV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit CofG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cofG</name>
        <name evidence="8" type="ORF">FIO04_07540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000561">
        <property type="protein sequence ID" value="MRN69536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="300" mass="33319" checksum="4A062D4116394440" modified="2020-06-17" version="1" fragment="single">EVLELAQAGKKLRCTEALFITGERPEQRYTQARSWLHSLGHSTTIEYIREMSEMILQKTGLLPHTNAGSLTKKEMSLLKHTNVSLGVMLESSSERLAAKGMPHEMAPSKNPKVRIKTLENAGDLMIPTTTGLLIGIGEEPQDIIDSLFLIKDINQKYGHIQEVIIQNFAPKPGTQMSGTLPPAYDFFLTVVGVARIVLGGMNIQVPPNLNPYNFGKYLNAGINDWGGISPLTIDHVNPEFPWPSISSVRDVTQTMGYSLRARLPVYPEFLLDNKFIPEALRAYLEPLCDGYGLVPEEYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL12</accession>
    <name>A0A6A8FL12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1348 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_04480</name>
        <name evidence="2" type="ORF">FIO04_07500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000060">
        <property type="protein sequence ID" value="MRN40281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000554">
        <property type="protein sequence ID" value="MRN69528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="140" mass="17317" checksum="406EA3BA2D3155F3" modified="2020-06-17" version="1">MINSPIKPPFNEETARAKVKAAQDAWNTRNPEHVAQAYTPDSRWRNRTEFFTGRQAIIEFLKRKWAKELDYRLMKELWCYTENRISVRFEYEWRDADNPNRWMRTHGNEHWEFDDNGLMRIRDMSANDYPIKELERRYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLE8</accession>
    <name>A0A6A8FLE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class III poly(R)-hydroxyalkanoic acid synthase subunit PhaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000430">
        <property type="protein sequence ID" value="MRN69349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009656">
        <property type="entry name" value="PHB_depo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06850">
        <property type="entry name" value="PHB_depo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB_depo_C" evidence="1">
        <location>
            <begin position="100"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="201" mass="22988" checksum="37ADC5128179C05A" modified="2020-06-17" version="1" fragment="single">IYSTQHEDKIRNLATIAPVIDSNQDTTVLGNFSRHLEPDRMFNSIGNLPSEQLYALFSTLKPFKQGVNKYFNLVENIDNEEFVQNFLRVEKWLYDTPPIAGETFRQWITDIYQRNLLVANEMKIGNEIIDLSRIKIPLLNIVAEEDHLVSPQCSASLNDAVSSPDKRLMRFHTGHVGLIASSYSQNNVLPKVGQWIKARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLG6</accession>
    <name>A0A6A8FLG6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_06705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000447">
        <property type="protein sequence ID" value="MRN69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="102" mass="11509" checksum="B6125DB9E6424621" modified="2020-06-17" version="1">MSNQYSQDSIKDIIDELDKETAKIVISKEIRGRYKKTSTVIRGMAHSMKDQEIIAITSELKTKIGTGGTYKEGRIILQGDHRQAVKQLLIKKGFSEQSIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLG9</accession>
    <name>A0A6A8FLG9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps17</name>
        <name evidence="4" type="ORF">FIO03_03580</name>
        <name evidence="5" type="ORF">FIO04_04930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000098">
        <property type="protein sequence ID" value="MRN61121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000262">
        <property type="protein sequence ID" value="MRN69027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_S17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_S17_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN61121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="111" mass="12286" checksum="AE5387D8FB6B8FDD" modified="2020-06-17" version="1">MARNFGIAVTPPRKDCADILCPFHGRLSVRGKLLSGIVVSAKAKNMVVVSREFPHQVAKYQRYERSRSRVHAYLPECIDVTEGDEITIAECRPLSKTVSFVVIEGIKGLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLI6</accession>
    <name>A0A6A8FLI6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000461">
        <property type="protein sequence ID" value="MRN69393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="150" mass="15984" checksum="1C26A5F6F0E42156" modified="2020-06-17" version="1" fragment="single">RSGNDEINIIKPRGNYGWPIKECALGSTISNTSTASSGSSHNNPNTANTQHGGGKLEDPVICFSPALEPSGAIFAASNRLGYQNDLIIASLRGYLREINLDSNTQSTILEGYGRLRDIIEAPDGSLLVATSNKDGFGIPGPNDDKILRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLJ7</accession>
    <name>A0A6A8FLJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000216">
        <property type="protein sequence ID" value="MRN68920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="270" mass="29179" checksum="24C511A10E392F78" modified="2020-06-17" version="1" fragment="single">LLGSFGTGAIIGGIAILPKLQSRVSIESLMTGSIGLLAVVIFTMGYVRDFGILCIVMGAGGVAYITILSKLYTIGMKSAPKWIGARVSAVYLLVLNGGLAVGSVIWGTIANTIGIPITLSVASIALAATIIARKRYSTTLVDDLDFTPAGSDHWSLPPQLSVDPPNSEGQALITIDYRIDPKLSDEFEQSIRELGRTLKSEGMAYWELFQDPADIGHYLKIRIAESWTDHMRQHERVTKNVQIMEDGIRALLKDGPQPIVSHYIGKAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLM0</accession>
    <name>A0A6A8FLM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_04495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000226">
        <property type="protein sequence ID" value="MRN68940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_sugar_transpr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="92" mass="9862" checksum="07C47B86FCD5A8E0" modified="2020-06-17" version="1">MFNFLVLTILGISATIFAVSSTMPQIIKGIKTKKMDDVSAWLIIALIVGLSLWILYGIAKSDLVIAGGNSVGVSLNVILLVLKIKYSRDPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLM7</accession>
    <name>A0A6A8FLM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000489">
        <property type="protein sequence ID" value="MRN69433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="108" mass="12250" checksum="F6023FDBD23CABD3" modified="2020-06-17" version="1" fragment="single">MIEEILVLVCFSLAGAISALTFWKHSESKLALLKHRRNQVVKPINATRSEIEALQFEKSILSHSITNIYEAVQKGKIGAIERDRLLLKYKSQLDTFNKKIGELQLAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLT6</accession>
    <name>A0A6A8FLT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000516">
        <property type="protein sequence ID" value="MRN69479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="215" mass="24417" checksum="E83E5BEB71583730" modified="2020-06-17" version="1" fragment="single">ERYVKPRQKAVLKVIRVNKTRAEVDLSLKQVSGEERKSKLIEVKKNEKASASMVIIKEKAKLNDAQVKEIEDKILQKYDYVYDFLEEVAKKGIGAITNIDLSQDILKAIEEEGNKIQIPHVEIRGIAEIAVRKPNGIDVIKSTLLPVETSKSATSTVSVTYIGAPRYRIVVEAENFKIAEKAMNNLVEKIHSNIDKHHGTFNFIREESKKTHLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLU3</accession>
    <name>A0A6A8FLU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000256">
        <property type="protein sequence ID" value="MRN69010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="186" mass="21665" checksum="AF824D0CFB9BAD4A" modified="2020-06-17" version="1">MKILIAEDDRDIVLLYKHTIEKRHHEVITSEDGEECLTIYHEEFQRARFGKRYSANKTPPFDAVVLDHKMPKINGMEVAKEILAINPHQRVIFVSAFVKETLIDSIKNLMQVVEVIQKPFHLTTLVDTIEDKEIYSELQNLNVDIAVVKALKPTHEQIKDLLDRLSRVRDMQEFVTSEEVTRRTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLX0</accession>
    <name>A0A6A8FLX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000558">
        <property type="protein sequence ID" value="MRN69533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="101" mass="12252" checksum="FA5FAA2DEBDD247F" modified="2020-06-17" version="1">MQDYFEIDRLVEDLAKIYSTACATTWFKLVRGKRPTREEFRSKVVEFMEHFEYTLSTFPEGSETGQFRNYARKILRTEIESVLQGKNKEVERRYKYYIDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM81</accession>
    <name>A0A6A8FM81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_05555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000321">
        <property type="protein sequence ID" value="MRN69150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="PTHR12814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="169" mass="18801" checksum="F9D11EDE041E5FC4" modified="2020-06-17" version="1">MSSSDFSEFVLDASAFYAGIPFQSSKKCFTTNAVYDEVKHIRRSYSPLEALIDAGNLIILEPEKASLNKVIATAKETGDRRKLSSADISIIALALQLRKTLISDDYAVGNVATFLKIPVKTLAFKGISELRRWVSFCRACGQAYESYISICRICGSRLRQRFKVVSDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMY4</accession>
    <name>A0A6A8FMY4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDPG_MGDP_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000458">
        <property type="protein sequence ID" value="MRN69390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="107" mass="12470" checksum="40802404E85DEF69" modified="2020-06-17" version="1" fragment="single">LYLYCQANNINFPELRDALNTKWNVNILEPREGIGGHCLPKDTKMFLHSSKSIRSKILRAAMEVDQHYRKYRQTRGGMNNYEDNSGDRTQITTIDDTQKPVFNNRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNG3</accession>
    <name>A0A6A8FNG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000549">
        <property type="protein sequence ID" value="MRN69520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="110" mass="12348" checksum="E6657C5E503B9972" modified="2020-06-17" version="1" fragment="single">AVIKHRSALYPKNRQYRLRDRIVILTDDGIATGATIIAAARWIRKHSPNYLIIAVPVAPLQTVDILQQEADAVDVILSPEALNSVGQFYENFEPITDDQVREILIGEAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFF1</accession>
    <name>A0A6A8FFF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="199" mass="24651" checksum="9CA878CBA51EA42B" modified="2020-06-17" version="1">MHPEKLFFIYVAKNEEWEKRQREDWDYVSSMSRFYRWWIKRNFELDFNVEAEILPVIPGKLFDRMSISYLSRDHIERGKSVYHFYLTYFKPFWTDCQTEGYAAENFGMIYWKRLEAPVSDSKRVKFFADMNCAKLSHVLCHEVLRMLGKKRKEYFDSIHDLWERHVYKDLPYIYYNERFRIVLKESSYRYVTIDVKHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFR8</accession>
    <name>A0A6A8FFR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Orotidine-5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="50" mass="5251" checksum="F94A08E0AD6D9856" modified="2020-06-17" version="1" fragment="single">GVGVQGGNIKQAANSGTDYFIIGRSIIGSKDPLKTAKTLQHQLVRVNIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG93</accession>
    <name>A0A6A8FG93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="7" type="ORF">FIO04_01865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000061">
        <property type="protein sequence ID" value="MRN68425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="266" mass="29276" checksum="326CE7719C18992C" modified="2020-06-17" version="1" fragment="single">MVRDISVFSDRCPRCGKGPMVTDNSSGEMFCGNCGFVVTERIEEMGPEWRAFSKEEHEDRSRAGIPTSLAMHDMGLATIIGPVDKDASGKPLSASMKSTIERLRTWDSRSQVHEPVDRNFRQAFSELDRLKDKLAVGDAVIEKAAYVYRKALEKGLVRGRSISALVAAALYAACRDTETPRTLKDIANASNIKKKDVARCYRLLIRELDLKMPVVDPVKCVARIASKAGLSEKTKRKALDILKRAEEGKISAGKDPMGLAAAALYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGC9</accession>
    <name>A0A6A8FGC9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FIO04_01325</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000041">
        <property type="protein sequence ID" value="MRN68321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MRN68321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="377" mass="41431" checksum="B7C3BF7B1EA5D310" modified="2020-06-17" version="1">MRITLSAIKADIGGIGGHTRPSEELVGTVRSFVGRKAKDLLIDYYVGYTGDDIHIIMSHTLSVDNDRVHKLAWDAFTEGTIVAKEQGLYGAGQDLLKDSFSGNVRGMGPGVAEIEMEERPSEVFCIFAADKTEPGAFNFPMWRIFVDSRSNTGLLINEKLAAGVTFRIMDVIGGKIADLKMWEDKPELEAALMYPGRYVIQSVLSSDGEHIVSASTDRLHNIAGTYVGKDDPIAIVRTQKDFPATEEAGSAFNNPHFVAGNTRGSHHLPLMPVKLNSAASLNYSLPIVSCIVFSMHNGKMTGPLDGFGTTDWDLQRLMAAERAIIMRNQGFIHPATLVPEELEYNKGYEARMSKLNKKFKPLAGESNLNKHNSKVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGF1</accession>
    <name>A0A6A8FGF1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000045">
        <property type="protein sequence ID" value="MRN68341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="460" mass="52189" checksum="6F36C526F0FA00CD" modified="2020-06-17" version="1">MAGIVAINTTNVTVSNNIVYLLSHCMRMLQHRGKAYWKMVVAKKAISGEGSLPPDDKLSLLARKEKLIGKNAIGYLSKRSPQFHSMHTIQIVLDGFFVDTEKLHLHPLIGAAKDSDSLYKIYHIFTKLLIERGQPERAAEFLDRHLRGNLIFKVDDDIYAFRNSSGFKPLVIASNKSKTLSIVASENSVHTSLKDMKFNDIRAGALIALRKGAVEEVLTNLPREAILMDPFEFIRESHVTSLFNNKSIYEIRKNIGREQANFLGCRMGQQIDTAYAEPDYTRPMTLGFSIKYQNFWKKFEMAEGIIKDRYDDADHMIDFSEQVSKNKLLTTGKSLKFIIQDRVRNKKIASVQGTIQTGSTARETIYYLRKAGVNCVVILVSYVPTADGRQVGLYTQNRELIANKYVGKVSSIDELNESVNREIGANALYYNSPEILARGIGVPENNLWFPEWVRFLDYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGM7</accession>
    <name>A0A6A8FGM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000053">
        <property type="protein sequence ID" value="MRN68384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="108" mass="12682" checksum="51D9F7FD12C41196" modified="2020-06-17" version="1">MSLEDLRSKALFQNTIDVWIMCCEEKAWDWYDVEAYKHFIYYLKSKGVKMQKFPLCIKESGGMYERGRDKSKFLEQLSHYNSDDAGAHTIKLSVEVLSTIRSFEKAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGM8</accession>
    <name>A0A6A8FGM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000105">
        <property type="protein sequence ID" value="MRN68585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="216" mass="23888" checksum="2A5E20E700A92CB1" modified="2020-06-17" version="1">MSFGNKWIKPQGESVGNKLLEGLKPQPPLKPRIEEAQNKLHLQISKLETISAKMQEKDQLIFKRIVHSVQNHDSHYARVLSSELSQVRKMNKMVTSAKLALEQIQLRLNTITELGDVVVTLSPAMSVIKGIQGRLSSMMPEADQSLGQISDLLGNIMTDSGHIPTAEIAAGSTGLNEDAMKIIEEASAIVEENMKEKFPDLPTNTMQTRKTEASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGN7</accession>
    <name>A0A6A8FGN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_01705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000055">
        <property type="protein sequence ID" value="MRN68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_S30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="59" mass="6734" checksum="4D1E850F065A58AC" modified="2020-06-17" version="1">MPTHGSLTKAGKVRGQTPKIQGKVRLSPVSKLRNKNNFIKRFEKRRPPGQKKPERGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGY6</accession>
    <name>A0A6A8FGY6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="10">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">guaA</name>
        <name evidence="13" type="ORF">FIO04_00830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="10"/>
    <dbReference type="EMBL" id="WJXC01000024">
        <property type="protein sequence ID" value="MRN68226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 10 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="221"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MRN68226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="510" mass="57235" checksum="D5D442008D20BF39" modified="2020-06-17" version="1">MDNIVVLDFGSQYSNLICRRIRDINVYCELLPYNTSIKELKQIRPNGIIFSGGPASVYFNDSPKPDKEIFELGIPILGICYGYQLIIDHFGGKVKKTSTREYGRADLIIDNKGDLFSTIDRKIKCWMSHGDAAENLPEGFEILGHTENSFSAAIANQEKRLYGIQFHPEVVHTENGSEILKNFSQKISRARPSWNMESFIESTIEDIRQRVGNEKVLCAVSGGIDSTTVAALFDKAIGKNLKCVFVNHGLLREDEEVLVTGLFKDYLQSEVIYVNAEKQFLQKLKGVCDPEMKRSIIGEEFAKVFMDVVKKNGPFQWLAQGTLYPDVIESGVSKGPASAIKTHHNVGGIPKWLNLKTIEPLRTLYKDEVRRVAKLLGVPNEFLQRHPFPGPGLAVRIIGEVTREKIRITRHASKIVEDELNAAGFYHKVWQAYASVGDDRAVGVLGDQRIYGHIATIKIVESIDAMTADWTRLPYDIIGKMSDRITNEVEDVSWVTYAVSSKPPATIEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGZ3</accession>
    <name>A0A6A8FGZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_05690</name>
        <name evidence="2" type="ORF">FIO04_02355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000194">
        <property type="protein sequence ID" value="MRN61528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000086">
        <property type="protein sequence ID" value="MRN68521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="60" mass="6776" checksum="5BB788297FC1B7BD" modified="2020-06-17" version="1">MDDEIPEDINVHKQIWGKDADQVIYGEVEKKEDDEQRCPICNSRIDEFGYCGCGGKLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH23</accession>
    <name>A0A6A8FH23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000155">
        <property type="protein sequence ID" value="MRN68745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="36" mass="4242" checksum="E9B6620B8EC04C4C" modified="2020-06-17" version="1" fragment="single">MKAIESGSKHLLIKRFTLRYPEQKLKFVGDGYQFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH28</accession>
    <name>A0A6A8FH28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="116" mass="12690" checksum="1427897EA15154CD" modified="2020-06-17" version="1">MRNSMKWPSSAKAINGLCWAAPFALIGVFPSMYQYLILVGIGLGNFSTYLLMKKYNGLNNRDQMIVGLISLASVPISILVDMTLFVSKHDLAVFLSRILIGLAYAVGGIHALLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH34</accession>
    <name>A0A6A8FH34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000160">
        <property type="protein sequence ID" value="MRN68755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="558" mass="60505" checksum="09D4CD4C28D33E36" modified="2020-06-17" version="1">MNNTRRGLPLTSSRLERIFPKLIPDQIRRVAAQGHIRSVQPGEVLIEQGDRAVPFFVVITGEVEIVRPCGASEALITVHGSGEFTGEVNMLSDRRSLIRARVTKPGKVIELDHKQMLNLIQTDAELGDILMRAFILRRVELIAAGVGDIVLIGSIHSAGTLRIKEFLMRNGHPYSYIDLERDSDVQKLLDSFRIAASEIPVLICRGQLVLRSPSNQQIADCLGFNESVDQTKVRDLVIIGAGPSGLAAAVYGASEGLDVLLLETSSPGGQAGSSSRIENYLGFPTGISGQDLAGRAYVQAQKFGAEMLIADAKRLICDRKPYIIEVGSGAGISARTVLIATGVQYRKLPLENLLRFEGAGIYYGATFVEAQLCGKEEEVIVIGGGNSAGQAAVFLAQTTKRVHMLVRSSGLVASMSRYLIRRIEESPKIVVRPHTEIVGLEGGDHLESVRWQNNQTGQIEEHKIRHIFIMTGADPNTRWLDGCITLDDKGFIKTGADLSAENLTASRWPLARQPHLLETSLPGVFAVGDVRGGSIKRVASAVGEGSIAISFVHQVIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH45</accession>
    <name>A0A6A8FH45_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">FIO04_00300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="WJXC01000006">
        <property type="protein sequence ID" value="MRN68122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="213" mass="23345" checksum="1BBBD4DC6AAD5996" modified="2020-06-17" version="1">MTPDNIAIFDYGAGNLFSLKAALERNGAQRVSIIRDIEGIEKFSGLVLPGVGNFDPAIRSIEPHKELLIQVIDDANNGGMPMLGICLGMEMLFNKSEEGILDGLKILDGEVVMFARTRVKIPHMGWNNLYVTRKDSKLLQGVNDGSWVYFVHSYYVKPKDKGLVAASSHYGIKIPAVVENGNLFGTQFHPEKSGSTGASILRNFLKACSQKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH70</accession>
    <name>A0A6A8FH70_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000171">
        <property type="protein sequence ID" value="MRN68795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="56"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="203" mass="21931" checksum="8D1CACC199A1C73E" modified="2020-06-17" version="1">MKNKTHDKLIKQFLNTKMVLDLSDLSRPNLDILEDIITTVNNMAEKVSNQQGPAAIKTILIAIDKSGYKEKIISYAVTLAKSLGAQIIAIHVIDKSSLGAAGDLLGYYRGGNIEEYEKEMKKKGEILLAEVEATVRKNGNINVTGAVLVDSSVANAIINYAENKRVDLILVGARGMAGIEKFILGGVATKIISHAQCPVLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH89</accession>
    <name>A0A6A8FH89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA uridine(34) 5-carboxymethylaminomethyl modification radical SAM/GNAT enzyme Elp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_00430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000010">
        <property type="protein sequence ID" value="MRN68148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="201" mass="22263" checksum="0A9981387A44FD1E" modified="2020-06-17" version="1" fragment="single">MRNLSLPSETEEKLETDYVSACKHIASQIQLRSDISRRDIAKIVRDASAKYCLSTLPRNQDILGYLDNLDSYRKLLMVKPVKTASGVVIIAVMPKPYACPQGRCIYCPGGISANTPLSYTGREPATMLAQKFGYNPFGQIRSKLSHICSLGHDAGKVELVIVGGTFPFMPHDYQREFVKLCFDALNCDNDKSVSSLSLHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHB1</accession>
    <name>A0A6A8FHB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000019">
        <property type="protein sequence ID" value="MRN68192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="237" mass="26864" checksum="5D8912FA651F0203" modified="2020-06-17" version="1">MREITLGHTPDADDAFMFYGIEAGKVKSPYFKIKHVIEDIETLNKHALKHELDVTAISAHAFAYLKDYTIANLLLNLVLGKFNEQEINFQLIPDAVLSGKVDAGLVIHETQITYYKSHLYNILDLGAWWHTETNGLPVPLGINVASIKSMTIEEIGRFNKLFKASILYGLEHRNAAVDYAMRYSRGQPKHVMMKFIKMYVNDITVDMGTDGEKAIKKMFKMGQEKGILPLISQLNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHC2</accession>
    <name>A0A6A8FHC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000117">
        <property type="protein sequence ID" value="MRN68624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="134" mass="15721" checksum="23A6861BF19DA78A" modified="2020-06-17" version="1">MKQFFQQFCNDVISLDPSIRFVGVADEHGLLLSMSERKDLKPLLNLEETQQYAITAATRQYTRIRWQNLLGKIDYTCSHYDKLLRATIPLTDKNNRLAYVIMFTFDVETANFHEIIMNKIIPLINRNSKHFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHF6</accession>
    <name>A0A6A8FHF6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="6">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadC</name>
        <name evidence="9" type="ORF">FIO04_01715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000055">
        <property type="protein sequence ID" value="MRN68396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="8">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="7">
        <location>
            <begin position="113"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="295" mass="32180" checksum="D76850F754EA01D3" modified="2020-06-17" version="1">MKNLRAYLEVRESLISFLQQDVGTGDVTSESVLSPDLSACAQIICKSGKSAIIAGLEEAGILFDICRCRVQTLVTDGSRVENGSIVMNISGRALAILQAERTALNLIMRMSGIATETRKLVEMVGKINRSIKVACTRKTAPGLRAFDKKAVLLGGGVTHRIRLDDMALIKDNHLVLADSIEQSIRLAREKINGCLLLECEVKNLAEMVSAVRAGSDIVMLDNFSPKQAKDAITQIRKMGVRKKVKVEISGRIDPHNIADYAKLQPDIISLGYLTHSPKAIDYSLEIMSNSDCQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHG4</accession>
    <name>A0A6A8FHG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000133">
        <property type="protein sequence ID" value="MRN68681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="171"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="463" mass="52175" checksum="2AD595FC907050F2" modified="2020-06-17" version="1" fragment="single">MKVLTKNSNELVILAMKGDAVSKGDYLLIEDGKLNRKMIVQIYDEEYLSSQSLIEDIVRDEVITASSTENLHDPLNIANLSRMIRDARLFRTKIRGTIDASGKISSDVTWIPSRVYSKLRRLSIAELNESLGRTGIFPIKLGRTRGDNEDFEIYAEDLDGKLNIVTGKKESGKSHLSKILIKTLVQHGAFVIVFDLNDEYGGIATNYDGSPSSLANQVKILQSGKGLSFSLAYCGKAAISNVLKNALDTPAASMREFFRIWDWLENRDNLEIEAFGNAINTWNINELVRDALVSRFHVLQASRLFLQNRADGLKFENIFSNKNKGAVIVVSMAKIIPLVRRMVVELVLNKLVDLLEKEIIPPIFLFAEEAHLYIRETYWEDIITRMRHFGIYPTFITNQPDAIGDGIYRQADNIFLFNFTNDVDLDKISKVSLADNDTVRSIVKTLPHRCCLAIGKVVSDLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHH0</accession>
    <name>A0A6A8FHH0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">hisI</name>
        <name evidence="9" type="ORF">FIO03_00105</name>
        <name evidence="10" type="ORF">FIO04_01770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="9">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="WJXD01000002">
        <property type="protein sequence ID" value="MRN60446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000057">
        <property type="protein sequence ID" value="MRN68406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN60446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="112" mass="12787" checksum="AB22BAB0DE602A17" modified="2020-06-17" version="1">MKKSIADIDFTKRNGLIPVVLQDRKTKDILMLAYTNREALDNTLKTGNAWFWSTSRSRLWMKGEESGNIQPVKEIRVDCDADALLYVVDSEAPVCHTGNRSCFHNKLVDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHH2</accession>
    <name>A0A6A8FHH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000137">
        <property type="protein sequence ID" value="MRN68691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="129" mass="14658" checksum="0EBBABD3BDB5AA1C" modified="2020-06-17" version="1">MVNKYSVARATEEEAGEVVSIWEVLGRRWSLLILKNLCTKEVIRFNEFKKLLSGISSTVLADRLLELEREGLVSKKIYPQIPPKVEYSLTIRAKELGVILRELGKWASRWKVPRITTNTKATSAVRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHM6</accession>
    <name>A0A6A8FHM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-type integrase/transposase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000149">
        <property type="protein sequence ID" value="MRN68724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="221" mass="26378" checksum="F56A8F606A1BD830" modified="2020-06-17" version="1" fragment="single">MDFVGPRYIKNDGRYYSLNIMDTTTHFVHINPIRGRDTNNVLQSVIRFWQHRGIPDYLQMDNELSFRGSNRHPHSFSKLIRLALSLRITVVFIPVQEPWRNGVIEKFNDSFNKRFVRGKTYKDFEDLQNCAGEFEIFHNQFHRYNAHKNKTPNEQITEEMNRDILSKDFRLPESSLPLKQGRIILVRFIRSNLLLDVFGEKFLMPKHLEYSYVVTLIDIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHN3</accession>
    <name>A0A6A8FHN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000153">
        <property type="protein sequence ID" value="MRN68734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="65" mass="7670" checksum="148ACD6824B13382" modified="2020-06-17" version="1" fragment="single">MKVKSLPYYLCNTSVAWHDVNDVGVAEVFCLNCVEREKMELEELEIWDILPREELVFTYADVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHQ7</accession>
    <name>A0A6A8FHQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000162">
        <property type="protein sequence ID" value="MRN68764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="56" mass="6026" checksum="7C60B75854F07A8F" modified="2020-06-17" version="1">MSFAYNAITISIAAGLLYGFTHSLILTPTLAALGWIVSDSAVFGNSLLVRKFYSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHR8</accession>
    <name>A0A6A8FHR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Redox-regulated ATPase YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ychF</name>
        <name evidence="5" type="ORF">FIO04_01430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000045">
        <property type="protein sequence ID" value="MRN68342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="400" mass="44310" checksum="9BEE749D95E5FB7C" modified="2020-06-17" version="1">MLIGLIGKANVGKSTFFNAATELEVQTANYPFTTINSNVGMTHTRVKCVCKEFEVQDNPIHSVCIEGTRFIPIRLIDVPGLVEGAHQGKGLGNRFLDDARQADALIHVIDASASTDKEGKPVLAGTADPLSDIKFVEEEFDYWLLSIVGREWTKVLREAENQVQKLEQLLAKRLSGLAIKERSVFDVLNETGLYHKKPVNWTQQDLLEFCQKIRLRSKPVIIAANKADLQSANGVIAAIKNNRPEVIACSAEAESLLRRAAKRGLLNYLPGDNSFEIKSGNSLNEAQKKALDIVKSLLGRYGSTGVQDAINQVCFRLLKFIVVYPVEDEVRLTDKKGNVLPDARLVPQYSTAKDLARLIHEDLAKGFLYAIDVRTKHRLGAEHKLKNNDIIKIVSASSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHW2</accession>
    <name>A0A6A8FHW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_08725</name>
        <name evidence="2" type="ORF">FIO04_03935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000195">
        <property type="protein sequence ID" value="MRN41110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000182">
        <property type="protein sequence ID" value="MRN68831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="134" mass="15663" checksum="EB3193BFF54DF146" modified="2020-06-17" version="1">MKNKTKITFNNREVGYVMVEFIEWHVDDICDDCLEEDECTQCHRDLVDINTYDFIHRLIANTKEFPDWKGVAEIYFTTDSTWLCYGGKDADGNILITRMIPIHSIDNIHIDSTEPKFSESKINHLDTSEKKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHX7</accession>
    <name>A0A6A8FHX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000098">
        <property type="protein sequence ID" value="MRN68566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="130" mass="13530" checksum="87E71134987BCDB2" modified="2020-06-17" version="1">MSVASLAALLLLTNPAYLPISALAVASSKVGGGALSPTPIIHNNKGPVIQETVNTRNSGLDMQINKFYSCISKVTHEPVEPLKVQVDNCYLQVFGTGSSSVGNINVETHSPTVSSSKISNTSPGILVEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI14</accession>
    <name>A0A6A8FI14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO02_02860</name>
        <name evidence="7" type="ORF">FIO03_04660</name>
        <name evidence="8" type="ORF">FIO04_02790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum02</strain>
            <strain evidence="7">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000031">
        <property type="protein sequence ID" value="MRN39969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000142">
        <property type="protein sequence ID" value="MRN61332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000111">
        <property type="protein sequence ID" value="MRN68606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN39969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="552" mass="59124" checksum="4575D7D7FA3C66E6" modified="2020-06-17" version="1">MATIQQGSAGGMPVLILKEGATQTKGRDAQKNNITAAKLIAEVIRTSLGPRGMDKMLVDTLGDVTITNDGATILKEIDVQHPAAKMMVEISKATDNEVGDGTSSVVILAGALIEKAEELIGKDVHPTIIVDGYRKSAIKAIEILNSMGQKIRENDKEDLIKVAKTSMQTKLVSRESDQIAELVVSACLQVSEKSDSVSKLDIDDIKVEKKAGGSLHDTKLIKGIVLDKEVVHGGMPKKVEKAKIALLNSALEIEKTEFDAKINISSPDQMNLFLEEENKMLKNMVDKITATGANVVVCQKGIDDIAQHYLAKAEVLTVRRVKESDMAKLARATGARVVSNLDDLTAKDLGSADLVEERKIETDKWVFVEGCKHPKAVTILIRGGSQRVVDEAERSVHDALMVTKDVLERPVIVAGGGAPEAYAAAKLRDWVSTLSGREQLAAEKFAESLEVIPLTLAENAGMDPIDTITDLRSKQSKGSKWTGIDVRNGKIADISKLEIFEPLVVKEQIIKSATEVASMILRIDDVIASGKSGGPPGGGGMPPGGMGGMGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI54</accession>
    <name>A0A6A8FI54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000123">
        <property type="protein sequence ID" value="MRN68646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="531" mass="56476" checksum="C3CC721006850492" modified="2020-06-17" version="1">MNSVNRPTINSQTGGKISRSPWITLAILSGVGLMAMFADTMILPAIPDIIRDFKIAYNTSSWILASFLITGAVMTPIAGRLSDMYGKKKMLLIIVGIYTIGISVAAISTNFTVMIIARIMQGVGASMFAISFGIIRDKFASEKLAVAQGIFSSMFSAGAVIGVAIGGTIINNFGWHATFLLVLPIAIVLFVAISRFIHIERDKGTGRISDKNTEFCCRFIHVRKDILLSESSNTTTEYDSSSANINENKSTIDIMGAITLSITVISFLVALQFIQTINAVASANLPIVIGFGAAAIISLSFFIMIERRADSPLIDLNLLVNKILLPANIINMIVGITALMVVYQTIPILIQSPQPLGFGGNALSIANVQLPYMAISLIVSVASGFIVSKFGNQTPTITGIIISIAGFFLLFVLHSTEFLITISLAVIATGLSLTQIGSINIILVSTPKQSNGISLGMTTLLYLIGTSVGPVIAGIIMQANQTFVNGISGSSFPAPQSYNLIFLTAALLSVVSIVLVGSIKKRPSAPRIDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI59</accession>
    <name>A0A6A8FI59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000074">
        <property type="protein sequence ID" value="MRN68478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="93" mass="10368" checksum="1FCC3083E907B6F8" modified="2020-06-17" version="1" fragment="single">MYPIQHIVLSNIEVIPNSSRARDLYLTLVKAAEEEILLIFPTTNSFIRQEKIGVIQVAKKVAKELNVQVRILMPVHESTGQSAQSLRGQNGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI63</accession>
    <name>A0A6A8FI63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_04515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000227">
        <property type="protein sequence ID" value="MRN68944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="5">
        <location>
            <begin position="268"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Mo-co_dimer" evidence="6">
        <location>
            <begin position="458"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="551" mass="60082" checksum="71020DBEB617EBFE" modified="2020-06-17" version="1">MIEKTGSISTTTSFVVGLAAGAVAIAISLIIRSFAGGPFIPELASQTLFSLTPGQFESQAVANFGPLAKYSAFAGAIIANFILYGLLAIWVDRLQNKLHRKGYVGKAILSSVVAYVILLIVTISLVTITEARTHTQPTSIIRLVLSLILPQIAFGFTLSSFYEKIRRPSRKPVVEKPSETTTEIDYKKRALLRAAIASAVALPILYLGLNRLFPTQEVQPPSSSSLSLLPLQSKSKPLGFEDPRLAPLLDSEVTPTYLFYRIDINPIVPVVDATSWTLTVKGLVNNPLTITYEEIKAMPPVKEYATLQCVSNKIGGDLTSTALWKGVRLKDVLQKAQVKPGAKYIAVRCYDGYDVGIPLERGLLDGSILAYEMNLAPLTSEHGYPVRAIVPGLYGMMNPKWITEIELVDNVYEGYWARNGWTNVATEDTHSFIVIPGQAPVRDRFRNLDVENINIVPGQKVPVAGIAFAGDRGIAKVEVSTDGGVTWKSASIKDPLSKYTWVLWTAGFTPATAQGNYRIVVRATDKTGKIQTAEVRPPFPDGATGYHMINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI67</accession>
    <name>A0A6A8FI67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="4">3.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000222">
        <property type="protein sequence ID" value="MRN68931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="286" mass="32355" checksum="7E43BC30FA8D8BC6" modified="2020-06-17" version="1">MVVPKTLIEVTVVGNDRKGVVADVTNFIFTIGGNIEKVNQNVVRGLFGMQLEASFQTIDKKKIDLGLRSLAKKLGMEIRVHYEEPNRLRNIAIFVSKEPNCLLRILEAKEKGLINANIPVIIGSEGTMGPIADGNRIPFHIIDDKQDPILAENKILKLTEQYNIDLIILARYMRILSPNFVWRYPNRIINIHPSLLPAFPGAYAYVQAYERGAKIVGCTAHFVTEDLDQGPIIYQESFRVKEMDTLDTIRQKGQSLEAETLLKATKLYLEGRLEIYWGRVHILGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIA2</accession>
    <name>A0A6A8FIA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF354 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000087">
        <property type="protein sequence ID" value="MRN68528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="299" mass="33531" checksum="A36AFB79AB7CF107" modified="2020-06-17" version="1" fragment="single">MTPKQVMFFGPAVTLLRESDHELLCTSRHYREAVELANVKNLKLKIVGRHGGAERYQKLRESASRIFELAGLINKFEPDFAITFSSPEASRVAYGLGIRHIGFNDSPHAEAVSKLTIPLTYHLFSPWVIPISAWLPFGISKTKITQYKALDPVAWLKRDQSPSPSVFPASLRELNLDSRKKIVLIRLEETKASYIADKTLENRISMVDALVNNLHNSINIVILCRYEEQIRQLMERYEARAFILRNVVDGIPLIASADVFIGAGGTMTSEASLVGTPTISISPIRFYVEKYLVSSGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIA8</accession>
    <name>A0A6A8FIA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO03_01065</name>
        <name evidence="4" type="ORF">FIO04_01105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000018">
        <property type="protein sequence ID" value="MRN60632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000033">
        <property type="protein sequence ID" value="MRN68279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028277">
        <property type="entry name" value="Lsm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037156">
        <property type="entry name" value="Lsm_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14894">
        <property type="entry name" value="Lsm_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Lsm_C" evidence="2">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="137" mass="15267" checksum="146B1C680191C727" modified="2020-06-17" version="1">MSAVLTRKFGEETVQFLGKKVSVETSDQKTYNGTLTGIDEKLDVVLENVESLGIIKMIINGSFVKEIKLMEKPFDFKALSDRIARVFPGLVKIREDVGAIIVMDKIKVTQAGIEEGSGLAADRVKAIYEEFIREIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIB6</accession>
    <name>A0A6A8FIB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000338">
        <property type="protein sequence ID" value="MRN69185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="219" mass="24811" checksum="636AC0C9CF64B4C8" modified="2020-06-17" version="1">MTVNLEQILGTVELLLHNQSPAHDFQHILRVYRNAEMISKKEEGADLDIVLAAALLHDLVVYPKGSTKTINSADESAEIAKKILSEYKWYPAEKIEKVVDVIRIHSYSKKLTPSTLEGKILQDADRLDAIGAIGIARTFSVGGSENRSLYDSKDPFCESDRKLDDTRWTLDHIKKKLLILKNSMHTKTAKEIAEQRTDFIESFLKQLRTEILYKGSGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE4</accession>
    <name>A0A6A8FIE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000099">
        <property type="protein sequence ID" value="MRN68568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="82" mass="9354" checksum="AC0239AFCCEAEEA6" modified="2020-06-17" version="1">MKRSGEPSEVHGTEPSRSGLISINPESQRDEIVDLKNELRNMKAELMGIKEYLMGIGEFLKEEVNFNLAELIYQFQHLSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIF4</accession>
    <name>A0A6A8FIF4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEM4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="294" mass="32160" checksum="6A77AD9CC03FAF52" modified="2020-06-17" version="1">MSLSGLVVVVTGSRRASELAHIIDSFGGIPYVAPTIGIEVNQGMNEEAGYFAYQILKEKVDYAVFMTGPGVYSLMSAARNLGIEKELIQILQQVTVIARSLKPKDALAMHGIKTKIVPKDNTSKGIAQLLRALGVAGKRVFILWHGSYSSELKTELEAEGAQVFESSTYMYSTDLKENGAEILKTMGYEYIPPEETKVLKLIEDISIAHIGAITFTSPPAARELFKIASQHGLNESLRESLNRGVIVVAIGPSTRKALEENDVHVDVMPTMYKMGSMIKSLCDYLDNEGSPKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIF6</accession>
    <name>A0A6A8FIF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000156">
        <property type="protein sequence ID" value="MRN68746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="334" mass="37954" checksum="6CE742F47E1E377C" modified="2020-06-17" version="1">MLKRYLDVLSTLFIPPERTRGRYSFADIPVKVSFEKSNVVFYGAPIDITTSFGKGTVRGPEAIRLTSARQIETFLLDEKVDIYDRARIFDIGDLKIPASVKNMRKRSPNNLASNLSYLGSKIHKITSLIHNANKVPVLMGGEHTLSYYTLKALSDEKPLVIHFDAHRDMKPEYEGIKMCHTTPFYHIMNDGYIPGKNIIQIGIRQTDRGENEIAKKNQVTTFDAWEVHERIDNLLKYIRKATRNVNIYISFDIDVYDSPYVPCTGTPEPFGLDPFDVRRILKNICSTAKLIGVDIVEVGLRNGDYREGTLASQTLFRILSRLPDLKKHSGTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN8</accession>
    <name>A0A6A8FIN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000127">
        <property type="protein sequence ID" value="MRN68658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="245" mass="26444" checksum="69E0011314D7E2EC" modified="2020-06-17" version="1">MDNSSSQIKDVSYSAKFECGSVSGNDGPLRPGHYDTDISIFNSQSYTVPFLWNAVVNNGKSTTSILKTLQPQTSASIICKNILQLYNIQNNTGNLVEGFIVIRPQINAGGLASFSGNSATVTSRPLSQDQLNLLNVQVFYSANALSTLPHVITMDKVLFSILNDTSGKLPAPLVGKTLDITLESQVNQVIDPEAQVRNILAAKYNLSNVEQTHLKIQIISVSLGASTMVDDHAISSLQVRPQPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ9</accession>
    <name>A0A6A8FIQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy metal resistance protein CzcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000312">
        <property type="protein sequence ID" value="MRN69131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="2">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="242" mass="26806" checksum="8F12A72535B6D479" modified="2020-06-17" version="1">MVPVRIVVDERERRSRIPGLLRQAGAVTDFAHLKVGDYVISAETAIERKTIHDLLNSVYDGRLLVQCSELVQHYTKPVIIIEGNILNLSDGAGAAVEDIIEDNERIYLINETLAKVALDFRIPIINTPHAEYTSQLLVTMVNRALEEGTNKGPLLKRIKKTNPVQIQQLSILSSLPGVGDKLAVRMLERFLTPQRALTASAAELARIPGFGTARALKVRKILDSHDYKSVEPAQRSLLDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIR1</accession>
    <name>A0A6A8FIR1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="13" type="ORF">FIO04_00325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="WJXC01000007">
        <property type="protein sequence ID" value="MRN68127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="67"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MRN68127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="908" mass="102296" checksum="A30326699E64F6F2" modified="2020-06-17" version="1">MGKKELTAIFSSDPDRYYKVSLFDRLGFKRQRCNNCGKFFWSLNEKQVCPDHQYYGFIGEPPTNKRLDYINAWKEIEEYFQSNAHSIIRRYPVVCRWRDDLYFTIASIVDFQRVIGDKVIFELPTNPLIVPQMCLRFNDIENVGLSGRHYTSFCMIGQVCNADAQGGYWKDKCIELDYRMLTNALGIRKEEITFVEDVWMGAGAFGYSLEYFVSGLELGNAVFTEFEGNENDYRVMTNKIIDMGAGLERLSWITMGTPTSYDCSFGPVVRKLVDNSGTSESPEILSKYFTAVSTKLDYMSGDIHALKSLIAKELKISDDLLTKMTAPYEAIYTIADHTRTLVLAISDGALPSNVGGGYNLRVILRRALSILERLGWSMKLEDIADMHIDYVKHMYPELEEHREDVRTILQIESGRYIGSRERMEAIANSIKSTEKKLMVDDLIRMYESDGVTPDFLVDLGAIDSIPPTFYTKLAELHTSQAAAQAQKPIYGLDGVAPTRLLYYEDKSIREFSAKILKVIDKKFIILDQTAFYPRGGGQEPDTGEIDGVKVLEVIKQADIVVHKLQGPSDFIDGKTVHGTVNDRRRELITKHHTATHVLNTSARFNLGSWVWQNSAFKEENYARLDVTHHSSLNREEVERIEKTANNVIRQNLPVKIKIYDRVDAEQDYSFRIYQGGVVPTSNIRIVNIENWDIEACGGTHVSTTGEIGLIKITKSERIQDGVVRLEFVAGEAAMNYIQKQENQLTMIAQSLGSSKEKVVESLQKSIVEAEAAKKKVKTMLRKITPSIAKSVSEEAKQLSSDGIKFYHVRDNEMDEEYHISVGEKSIESDPSLIYVAFISKGEGIRVIVFVGEQAQKKIKAASIARQISVQLGGSGGGDGRFGQGGGRFKDKISTALVSVEELVLKSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV3</accession>
    <name>A0A6A8FIV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1512 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000442">
        <property type="protein sequence ID" value="MRN69365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009995">
        <property type="entry name" value="DUF1512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07431">
        <property type="entry name" value="DUF1512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016495">
        <property type="entry name" value="UCP016495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="379" mass="41764" checksum="A3BF9F2E9ACB4B63" modified="2020-06-17" version="1">MLTVPVLLLGGLFGPGGFDSNNSPLAYILWFAPIIVLMIYGQKFQAWMILGDVSKSLTRLKTMKETARKEVIDYIKTSIRPAADPSERIDKFLEYFVIMPVDLDPQGIIRKLDLVMRTKDERIRSEIKRMAEGMTEWQASRIENILEAATALNMIYKIVRHFYLMGKRTTGMFVLVQLQMVMPLLLQEAEALESAISAFKKGLPIGDGIGPMVVGRMMLGKEKKPIARETVYSEEVRMGRKLYMLKAEGPAGSVGRPGEAVYRLIAELGLRIDAIIMIDAALKLEGEKTGAIAEGVGSAIGGIGVERYQIEDVATKFSIPIYAIIVKQSVQDAITVMRKEISDSFDKLNNTVSAVIEDKTLEGDSILVIGVGNTAGVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW0</accession>
    <name>A0A6A8FIW0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NosD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000449">
        <property type="protein sequence ID" value="MRN69375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NosD" evidence="2">
        <location>
            <begin position="88"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="332" mass="35589" checksum="DBFBAEADA0CFD5FC" modified="2020-06-17" version="1" fragment="single">KVASASIAKTTFPAYIIDVHGSLKIDSVKITSWDPTTNNYAITNGSRTGSDVFIFGAPRPVIEVDTDATTPTDITNSEIAYLGFEAGKHKADSGLSFYGGDGSVLRNDNIHHVYFGLYTFGVGHMIIENNIIRNSGHYGLDPHTGTHDMIIRNNIVYDNNGSGIICSLNCYNILIENNKVHDNAENGIDFSRNMTKSIARNNIVYNEPSGIFVSQSHNNQISNNTISKSGNGIQVGSGSSNNKIFGNTISYAIREAILIDSGSSVNTFTSNKIVSNTPQGLKIVQDSTSKNNAFANNQIVTSGGISTTTPSTAPPALGNTLKHPPDKEISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW1</accession>
    <name>A0A6A8FIW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GYD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_10075</name>
        <name evidence="2" type="ORF">FIO04_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000570">
        <property type="protein sequence ID" value="MRN62369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000152">
        <property type="protein sequence ID" value="MRN68732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014845">
        <property type="entry name" value="GYD/TTHA1554"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08734">
        <property type="entry name" value="GYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN62369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="97" mass="10506" checksum="AD783530CA6DBEB3" modified="2020-06-17" version="1">MSHYVLLVNFTDQGIKNVKDSPKRAEAFKTAVEKTGGKLLNLYYTLGKHDIVAIVEAPNDEAIASVLFATGSQGNARTKTLKAFPMSEAANIIKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX4</accession>
    <name>A0A6A8FIX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000462">
        <property type="protein sequence ID" value="MRN69395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="330" mass="36843" checksum="97E6DAE0AC4335FB" modified="2020-06-17" version="1" fragment="single">QSVRIGYNPGSLLSMKEVLLFSKLADRSMDVDSLWVPESWGREAFSTLGAISQITNRVRIGTSVVSAFARTPATVAMAATTLDLLSDNRTVIGLGVSTEAIVEKWHGITFSKPLQRMQEYVECLRQMITGEKVNYSGTFFNVQNFKLLYKPPRRFIPILMAALNKKMIALSCAIADGVLLYLRPLEELRRTVAHIKSATKNLDRQFEIACVFIGAVSNKEPEKARQRAAKTLAFYIAVGKYYNEFLSTNGYAAEVHRITEEYKFNGLDAATKYVSEEMLDSLTISGNSEQCIHSIRRFYSCGISLPIIQVNPVGDSETSFREMLSTFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ3</accession>
    <name>A0A6A8FIZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000162">
        <property type="protein sequence ID" value="MRN68762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="62" mass="7172" checksum="F53C9F7B8C5D2627" modified="2020-06-17" version="1">MSEVWNKIYKSDSIFFGEEPSNFALLCFNHMKTNDAKKVLELGAGHGRDMTFLHQMKLKLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ12</accession>
    <name>A0A6A8FJ12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000168">
        <property type="protein sequence ID" value="MRN68782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="119" mass="12973" checksum="5017ABF8ABF3D83D" modified="2020-06-17" version="1" fragment="single">MTTSHLVSGAINWDKTIFVQKFPDVGEEVQVERVINFPGGKGANVAVSSARILGRDKVALFGALGSDFIANKHLEILRKDGIIIDLIQFTKEASSGQAYIIVDSYGRNSIMTFKQANDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ75</accession>
    <name>A0A6A8FJ75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twin-arginine translocation signal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000086">
        <property type="protein sequence ID" value="MRN68523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="419" mass="46514" checksum="5AA63D82114D46AA" modified="2020-06-17" version="1">MPWFDTKVSRRKFLKLAGSGIAIVVVGGTVWRAFSNGVFSSGQGPAYEPWKDWKAESQQGAGPLSLIASAILAANAHNAQPWLFVVNPNRIDLFADTKRNIGTIDPYLREMYEGLGCALENSVLAAEAKGYSYNLKLMPNPTSKTHVATISLITHKKSNIGRIGDTTTATYSPVSEALSLYNAIPHRHTNRGPYDKNRPVTQDILQSLGSLKQTIGPGVVLLFWFTTDEQRRKVGDLILQATQAIVADKQQSYDDFKWYRPNWQDIQTYKDGLTVDTSGTPWYIDVLAKILPPISEEAFDSSQLQLAKDAYIATAAAFGIIAVHDVFDNSQRLQGGMFYQRMHLWATSNGLAMQPMNQMTERADREVSLGIKQTFGNALRALIANPNWQALMTFRIGYPTVEALSSPRRSIQDVMFSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ94</accession>
    <name>A0A6A8FJ94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000407">
        <property type="protein sequence ID" value="MRN69311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="114" mass="11627" checksum="E87720D20F9466D4" modified="2020-06-17" version="1">MNKPILMAMVALVTLMGTAFALPAFQIANAQYGGATTSAGGGLSVGGGIEQQLKLAREKVSNAQQAGAYGSGTPMLGTTINSTLLFIIIITVIFGGVAGMFFVRARTPSKEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD1</accession>
    <name>A0A6A8FJD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_00670</name>
        <name evidence="2" type="ORF">FIO04_07585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000011">
        <property type="protein sequence ID" value="MRN60554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000570">
        <property type="protein sequence ID" value="MRN69545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN60554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="134" mass="15235" checksum="CE0034FCF80A7622" modified="2020-06-17" version="1">MANFAELEKTAEKYVNLKRQKKMDQERTELEEDLNNISISIIGYFSSPEFAFPLERQEVVSNGTTTYVYKNNSTYPNLFEFISELLHTPIPIAVESAKFGPGEIIVNGDNIKAARRELGHCIIELQKLIIGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE6</accession>
    <name>A0A6A8FJE6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase_M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_04405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000217">
        <property type="protein sequence ID" value="MRN68922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="102"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="413" mass="44884" checksum="C9BDEF02AE0FA28F" modified="2020-06-17" version="1">MEQQDNKNRVRAEVKFPLILVHTPFGLNFFEKVANTKAARVYAKFNIYLMPIITALAIFLIVGSLIALFSNSTVRAGVREVGPQSNLLIPGLNPYLPWTYGWIALVVTIIIHEAGHGIVARVHNIKIESTGLVLILGFPIGAFVNIAQEELSRTPLKQKSAILTAGPLNNMVIAVVSLVALFFITSTLTPISTNIIHQSGVVVVGVGDHTLAGSIGLSKGSVIETVAGQKVHSTDDLGKFLRSNLGKTVNITWKDKAGHQIIRSVPIPQFVEAGRGILGITITDVAPDPTQVLSRYKNAFSSNPIALLLPPTMAQGSVPYSDLMAHEYHSNVLGSAFPLVANMLFWLWFINFNVGIFNALPIGPLDGGQFYKSLIENRIRSRPSTLKNAPTLVTLVMTAIVVMAVLLPWLWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG2</accession>
    <name>A0A6A8FJG2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000226">
        <property type="protein sequence ID" value="MRN68942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="103" mass="11307" checksum="B79166EB7676F1B5" modified="2020-06-17" version="1">MERCSTVSFPRVIKQKVQRIENCNQYFVVSTDGDESPVIAKYIIIATGVTDTKPDIKNYSQIDGKGAWHCPHCDGLEAADKKLTIIGNGKNGGIISYAKEFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH0</accession>
    <name>A0A6A8FJH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000483">
        <property type="protein sequence ID" value="MRN69424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15452" checksum="95B042E913932CA4" modified="2020-06-17" version="1" fragment="single">LLGNGIVYPAALYGSLKMNEVFGIHSSAYSLDEFCHSPIFSIKSNDRIIILGNNACDLRVSKTIMNQLDKLGVSTLYVDCRKRSMIETLLKSIFFLQLYAVKLAVKNLLKDCYFLKNERLLALSSNLIYGSTLRSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH6</accession>
    <name>A0A6A8FJH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000050">
        <property type="protein sequence ID" value="MRN68367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="1">
        <location>
            <begin position="51"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="224" mass="25185" checksum="528E026A7DD3877E" modified="2020-06-17" version="1" fragment="single">DTIIGELTAEFDTIKIEINLSADKLYVEVIDGYRGMSNKRNLLDEERHSIVLFIEEIVTEKKNVFMEAFGKVDSNLRQTFSEVTGGTAWLEVENKEDEFSDGIMLMAQFQGKPGRESTALSGGEKTMAAIIFLLALQSLKPSPFYLMDEVDAHLDAQNTERLSKVLLERSKDNQMLMVTLKDATVAQASMIYGVYSQDGVSRVVRYKHPSQLPLEEIRSEASAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJI0</accession>
    <name>A0A6A8FJI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FIO04_03205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000137">
        <property type="protein sequence ID" value="MRN68689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="33"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="213"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="443" mass="50324" checksum="1E43D10414820D4E" modified="2020-06-17" version="1">MKTFKELGMSTEIVRALEENGFDMPFPIQETAIPFILKGIDVIGQAHTGTGKTAAFSLPILSRLKRNGPVQALILAPTRELAVQITTEINKFAKYINIKAASIYGGQSINLQLDQLKRGVQIVVATPGRLIDHLKRGSIQLDDVRFVVLDEADRMLDMGFIDDIKFILFYVSEDRQTCLFSATMPPEILRLAHDYMKEPQEIRLNEEELSLDTIDQSYLIVHDKEKFKHLCNFIRKRDHKQTIVFAATKQRTQRLAAELKQEGFKAITIHGDLSQKQRDIAMYRFKKGNEDILVATDIAARGIDVPAIGHVINYDIPEDPLMYFHRIGRTARAGGTGRAISLVSQDRVENFGRILRQTQHHIRKLNEEMGISVPVVRQQQQRRQYHTTSYQPRQGYGGSSRSRAGYGYRRGYGDRRPMSSNGNSYRGGSSGAWGRRGKFEKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJK6</accession>
    <name>A0A6A8FJK6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="4" type="ORF">FIO02_00050</name>
        <name evidence="5" type="ORF">FIO04_01720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000001">
        <property type="protein sequence ID" value="MRN39425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000055">
        <property type="protein sequence ID" value="MRN68397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="PTHR40704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4" evidence="3">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="62" mass="6604" checksum="337210EE6B471FD4" modified="2020-06-17" version="1">MAREVACKKCKAVTVGKVCPVCKSADLSPDWSGIILIFEPAKSMVAATLDITVPHKYALKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM0</accession>
    <name>A0A6A8FJM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_00025</name>
        <name evidence="6" type="ORF">FIO04_05380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000001">
        <property type="protein sequence ID" value="MRN39420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000304">
        <property type="protein sequence ID" value="MRN69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN39420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="101" mass="11192" checksum="99CA483F1242B05A" modified="2020-06-17" version="1">MTRIKVAVKDEIIVGKGKELNVNGIRIALFNANGKYYAVEALCRHQDGSLAPGKVDGEIVECPLHSWHYNIRTGELLDYLGGVKLTTYDVDIKGNDIYVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP3</accession>
    <name>A0A6A8FJP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03875</name>
        <name evidence="2" type="ORF">FIO04_03225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000109">
        <property type="protein sequence ID" value="MRN61179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000138">
        <property type="protein sequence ID" value="MRN68693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="234" mass="26323" checksum="27620459A5974381" modified="2020-06-17" version="1">MFPTTVSVPQAIKEILSSNNLYLQALLSGIANYTALAQKIKPDIEKLTASKVNIGTIVVAIKRLVDNLQNDEGIQSNPTVTNTHPIIEGARMSLTGNIIDIDFNESKFDQLSYIFDQLLEKEINHDYNLFQTDKQIRLLVDDDKEVRNIVATASKKFDGRIKGGLSKITITIPSILNEINNNTYYNFISSVSDMIYNSRIHVQDAFFTPNEIVLILDDKDAARAYELLRAKITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJP6</accession>
    <name>A0A6A8FJP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000162">
        <property type="protein sequence ID" value="MRN68759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="162" mass="17597" checksum="4E8D13107CABC2BB" modified="2020-06-17" version="1">MAAFGTTVNEIGFLKALHPGIWGVLQLVTGSLSDRIGRKILIYPGMIVQAIGVWTVLFAHSFFGWITGMSLLGIGTALVYPTLLAAISDIAHSRWRATSLGVYRFWRDLGFVFGAVGIGFIADISSISIAIQFVAWIALASGIFVLIVMRETKRTSSMTMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJW1</accession>
    <name>A0A6A8FJW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000162">
        <property type="protein sequence ID" value="MRN68763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="12460" checksum="6B7217F02F127CBD" modified="2020-06-17" version="1">MANKVTSKELRDRKYQYMFVDVREADELEKGKIDGAVHMPLGQLLRKARHDDLKDLKRKQICTYCSGGYRGNMAADELNNQGFDAITIEGGYSAWKDGEKTKRDNNSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK04</accession>
    <name>A0A6A8FK04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000324">
        <property type="protein sequence ID" value="MRN69158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="69" mass="7451" checksum="25B171AB8FDF74BB" modified="2020-06-17" version="1">MNQLTGITVVLGKNDTQHLSFLDPGQTYFFSPKPDTNITTVKISTNEGIVVQGDYRSPTKVLGLPGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK24</accession>
    <name>A0A6A8FK24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000380">
        <property type="protein sequence ID" value="MRN69266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="147" mass="15583" checksum="333366C366BE5CCF" modified="2020-06-17" version="1">MISPGRNTTPGAAPAASSSSSATTSGANYNRTGFNNLYVLTFNGKTFPVKYTITGGKLVGMLADKDRSTLVLVLNPGPNGGNFTTELPRNLIDSKGASNADTKYLIKIDGKGVDYKEVANNLNARILSIDFSKDNRFVEIIGTQMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK33</accession>
    <name>A0A6A8FK33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000385">
        <property type="protein sequence ID" value="MRN69276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="DUF5519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="DUF5519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="119" mass="13722" checksum="A5C6A76C03DAEB09" modified="2020-06-17" version="1">MGTILESIKKELLSWPYVTAEPHRFGGIEFRINKREMGHIHGDRVADLPFPMDVKNELVNSGRVSPHHFLPQSGWVSYWIKGEQDIPAIIELFKKRYDYLKPKMNLVNATLFPSTTANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK34</accession>
    <name>A0A6A8FK34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000340">
        <property type="protein sequence ID" value="MRN69188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="68" mass="8180" checksum="76AB58B87E1DDB3C" modified="2020-06-17" version="1">MFTWERIHLRHMISDYANHDMLSFYPIDMVIFYHSKTGYTVERRRHKIDEISNIHQAVIYGRAKLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK55</accession>
    <name>A0A6A8FK55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_08500</name>
        <name evidence="2" type="ORF">FIO04_05850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000185">
        <property type="protein sequence ID" value="MRN41066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000351">
        <property type="protein sequence ID" value="MRN69208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="161" mass="17839" checksum="5601B6E42A2BF347" modified="2020-06-17" version="1">MDIPKVHYSVLLGFLEILDDLGGKSDVAGIASKQGLELDDLLPILESGEMLGLIQVTAGDVSITEKGHLFIVASPKVQKKMLRDVVINLDTFKKLVDLVKRSEKGRISKDEVLEFVSNQDVATQSPDGDGSNEFDWIVEWGRQALILNYDANEESISIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK67</accession>
    <name>A0A6A8FK67_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000347">
        <property type="protein sequence ID" value="MRN69202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="236"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="463" mass="52483" checksum="5AC34ABF83F25255" modified="2020-06-17" version="1" fragment="single">FKRLRSVYGAEFENSLVPHEQFVSDPFWNRVIPTVQEIKDIEIEKKAAGEEERILAKQNTIKLIEDPDEIQRTAVDIGTAAKNEVLIIFSTPNAFHRQERLGGIQALKEAVEKRSINARILTPKDESIENTVRTLMQQGKHPKIEMRYIEPSLQSQVTTLIVDRKSSLVVELKDDTKESIYEAIGLGIYSNRKATVLSYVSIFESLWKQTELHQQLGTLYEQLKIHDQMQKEFISVAAHELRTPIQPIIGLAEILRSKKDMITTSRDVYDEYLSIIIRNARRLKELTDNILDVARIESQSMKLNKQKADIASLILQAIQESIENQTNIINHNVKLMYNPSRKNDESNIVLSVDKGRIIQVITNLISNAIAFTKKGVISITKETRMEEDGSSVIVTLKDTGSGIDLQILPRLFTKFTTRSEKGTGLGLYICKRIIEAHGGKIWGENNDDEGATFGFSLPIATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK81</accession>
    <name>A0A6A8FK81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000111">
        <property type="protein sequence ID" value="MRN68607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="167" mass="19194" checksum="49A5031858B8AC17" modified="2020-06-17" version="1">MRLIDKQLNVPEKILKMKNFNDAFELVKLAVNSKFNMHRAGLSLILQGLPSRIGAYHILGSNVIVVNRTILNIIQQHKSIEEYNSYLFMVLVHEYLHSFGIIDELGVRQMTYDLCCSLLGIDHPASIMAKGDPSTLFPELNLLRGERFDEHFEVIKNFDKTTQSYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKA8</accession>
    <name>A0A6A8FKA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000381">
        <property type="protein sequence ID" value="MRN69268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="196" mass="20557" checksum="703B351CFED63F52" modified="2020-06-17" version="1">MAQINQSKFGTHILLMLILALTTFIFANSIEANILTTNIAYGQNKPSSPSLSTTISHKTSKLHAIRIASPLRGQDVPVGKNLVVSGISAPGNSTTSSNCHVSVIVNGIKPYQNASGVGPKGQNDYSKWTFLVIPKYTTVKQGTNKITSKFSCGNNPSLVSYYSLNVTGLVGAVGSSSRSPAPAATTNNTPGIITPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKB3</accession>
    <name>A0A6A8FKB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000078">
        <property type="protein sequence ID" value="MRN68490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="134" mass="14640" checksum="ADC1F43CB6C3037E" modified="2020-06-17" version="1" fragment="single">MIVWYTLKRSDAAIIIVMTTITDSMRKKLETIEKSASVQEAAKKMTDKNVSSLIVVGPDGKPQGLVTERDLVKKVCLNDLRTSLVTNEQIMSSPLITIDSKSSPSVAADMMLENNVRHLLVVDEGSANKPIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC9</accession>
    <name>A0A6A8FKC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMC-Scp complex subunit ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scpB</name>
        <name evidence="4" type="ORF">FIO04_04560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000231">
        <property type="protein sequence ID" value="MRN68953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="201" mass="22527" checksum="1408A192109FCCCE" modified="2020-06-17" version="1">MSGSLPAEEITARIEAALYSAGRPLSIEELVRASGTNSKSNTRKVVNELIKKTKSVFTAIEITELADGTFVLQLKPGYTPLIRKFAQRPLIPTSALKTLSYIAYEQPVTSKRLMQIRGSQVYAHLRTLKQMGFIELEQLGRSKTYRTTKKFRSYFGVTDLESLRNSLLTTPNNQSKNNKLTHRNNLMIAATASPMEEAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKD5</accession>
    <name>A0A6A8FKD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000083">
        <property type="protein sequence ID" value="MRN68510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15679" checksum="427D72028E64F042" modified="2020-06-17" version="1">MLSIHIDGASRGNPGYSGIGIVITKDNDKIAEYKEFIGIKTNNQAEYIALKKALEIASSIDDEITVLSDSELVINQRTNKYKVRNKQLKLLFKEISNLEEYFRIVIYRHIPREINRYADSLANQAIDERIKYKNAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKD9</accession>
    <name>A0A6A8FKD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF59 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000400">
        <property type="protein sequence ID" value="MRN69298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="106" mass="11951" checksum="C2D8B276E148C877" modified="2020-06-17" version="1">MSQDIQQTRRQIFDELTKIVDPEIGVSIMELELVDKVDINKGNIDIDLHLTSPFCPAVFGFKIAQDVRDNVYRLPGIEEVKVNVSNHFMADAINKQVNESKPPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKF4</accession>
    <name>A0A6A8FKF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000244">
        <property type="protein sequence ID" value="MRN68983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="336" mass="39202" checksum="C73BEFF9E20D6A9B" modified="2020-06-17" version="1">MAEFFNRLSLSAFEDMAGKSTEDISSRLKSLEVRFENDIKELIELSDGSKLRTRLLRSASAEFILKGMVNESSLTTRTEYINYWMSKLILCQKTVILLVNILINKHNRFKFLWKKHEEKDNSNTKDERYLLHIINEVYGQIYGICQNIGTAIRDYFDLFQKINSNISKREKDFKALPVQDPEIQVSERIDEIIRETENCLLVNPSESILGLSAVRIGLESLIITKIGDKIRQHIRMKSQTNDVNIRFTSKLKTEDVFHIINELFPKQKQYEALDKIYTMSCDTLHRAISYPNYISWGCFSLVREELEKMIGKLKPDSVNLENVIAQLQNEEKLYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKG1</accession>
    <name>A0A6A8FKG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000091">
        <property type="protein sequence ID" value="MRN68540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="197" mass="21914" checksum="8DA3BC499741A9D4" modified="2020-06-17" version="1" fragment="single">MAVVLFVLLCSYYQYFGGRCKKRTVFIVSTLFINLDGTSRAQMLNMHFQYLKVANVRVRYLATESKGDPVLLIHGLGGSIESWLNNVEAISSHNLQVIALDLPGFGLSDKPKIAYNIEYYSKFISKFIRRLRIDSRSLCIIGNSLGGHIAAEFAINYPLAVSKLVLISPAGALPVSFKGTPELHNYINIVKAKTVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKP0</accession>
    <name>A0A6A8FKP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_07180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000508">
        <property type="protein sequence ID" value="MRN69466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="67"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="272" mass="29596" checksum="DD8DE67703412294" modified="2020-06-17" version="1" fragment="single">MFPIHDDAERIHGRPYVNYSLIAINAAVFTWEVLVTGFFANGQTTSEIFLEYGAIPKFVLAGDIPIVLTSMFIHGGIVHIAGNMVFLYVFGDNVEDRFGHIKYLAIYILWGLFAALVHSIYAVAVGGGEVPAIGASGAISGVLGAYLIMFPRAKIYTIIIVFFITTIRIPALAFIPFWFILQILFTLIGQSGGGGVAYLAHIGGFIAGVGTGYTWKYLAWKKMSLSIVGKTRKMRPKIEDVSPSLEPEVIEGADFFEIIAEIHGIAAATDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKQ1</accession>
    <name>A0A6A8FKQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000472">
        <property type="protein sequence ID" value="MRN69408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="187" mass="20698" checksum="90A61F1374856B6F" modified="2020-06-17" version="1" fragment="single">MADSSRGDISYANDFQTNNRPDDIAAPLTATGPLKNPIAEAVRNFMDVKKTCTLFSPQIDVNTFPTDIDIAKPIGFSGICDVCQSGQIEAVWNFVEDGSLAKVIHACDAEAVMRVTHQSEEKRKALRHASVRCLADLVNYWIGHTEVYLKAEEILPTESYDFVTDVERPPSHGGYISLGDLKENHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKQ2</accession>
    <name>A0A6A8FKQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF106 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO03_03190</name>
        <name evidence="7" type="ORF">FIO04_05315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000081">
        <property type="protein sequence ID" value="MRN61048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000298">
        <property type="protein sequence ID" value="MRN69103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="202" mass="22973" checksum="788BC37D38B1E1A4" modified="2020-06-17" version="1">MNILDPLIMQMPGLTPHYTKHPIFPDMLTAMIVASLISIALNIAIAMLRKKTTDFEKMNKVMKETNEWRKQYTAAIKKQDRALIEELKKKQAYVNKMSMEMQQQQMRPMLLYMVPSFMLWIFVFPTIFGATTALSPIQVPWIMCSSAQVQADSQVDKSGMHKGPCLVPGEVFLWGWFLITSFAFSGIISKVTKTTMPSLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKT0</accession>
    <name>A0A6A8FKT0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000313">
        <property type="protein sequence ID" value="MRN69133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="225"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="357" mass="38754" checksum="F5AE87067EFD3394" modified="2020-06-17" version="1" fragment="single">MFLSTNNMPLTIQDISAINQIKHKSASSSHNPQTTTKGGNPTPSPAQSDMLGCITYDSSTRSIMISCSSASLTDINNKLHDSNVLAKQAIDSTSWLLNANLIIDKGSKFHINSTDTKWLKIISSSSAGMGSHNNRRGATSGSSNVNSIHVFGSLNIDSVKITSWNPLTNSYVTITTSNATIPRPYLRIEPGATGPTNIVNSEIAYLGFDTSFAGLGAGGLNYYAGDGSILRGNNIHNLWYGPYLSGVGNMIIEKNQSHHNLNYGFDPHTGSHDIIIRNNLAHDNGQEGIICSVNCSNILFDNNRTYHNEKSGIMLSRNTYNSIVRNNFIYNEINGIHISQSHNNQVYNNTISNSVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKX0</accession>
    <name>A0A6A8FKX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Archease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO03_03615</name>
        <name evidence="7" type="ORF">FIO04_05650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000099">
        <property type="protein sequence ID" value="MRN61128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000330">
        <property type="protein sequence ID" value="MRN69169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="141" mass="16035" checksum="A242398ADA5FD7F8" modified="2020-06-17" version="1">MTGFRYLDHMTDVIVEAYGNTLEDAFANSARGLVNTMFELSEVSPDMEVAIYAEGHDLKSLLYNWLEKVMLIMLIDNILVSDSKIIISGCNGMYSINAVAKGEHTDLEKHHYKIEIKAITYHEMEIKQGCKDVTIRFLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL13</accession>
    <name>A0A6A8FL13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_03420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000151">
        <property type="protein sequence ID" value="MRN68730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="41"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="303"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="468" mass="52739" checksum="FCCB2E1A8C17D6E8" modified="2020-06-17" version="1">MLNSKPSTRASSPTSPPPIISAISSLKFPFKLTKDQTEAVDAWIANGYKGSIIYSTGTGKTEIAFECAKRACEALLHNEGNNVSNINNNSFNILFLVPRIVLVQQNINRLTSYGIPQERIGAYFGERKEVREITISTYQSTISNLDLINKSNMIIFDEVHLVSDTATTLRKVFDFVTAADPKKPLLGLTATIDEQDPKYNTILSLLPPVRRYMIKDAVKDKRLARPVVIPIKVDLTYNEKKIYDECSAKIRNISMYLNTSDPKSISSLLRTGGRTAGLARAWFANVKERKNLINCAKNKLLAGVDIIATKHSSERIMVFSETIESIQKLKEMLRQNKGIEAMLIESKLKSTERQKILAQWGKEFFPLLSVHTLEIGYDVPEVRVAIILATSSNMNQIVQRIGRTLRKTERKDTALIYTIYLSETHDASTLKMVRKATDVDMRGHENNDKKNRRTISVSGNNGNLDRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL14</accession>
    <name>A0A6A8FL14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000358">
        <property type="protein sequence ID" value="MRN69223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="236" mass="27408" checksum="5D1F25B0C90F45CA" modified="2020-06-17" version="1" fragment="single">MIIRTAKKSDKEEVLKFCSNTFEWGDYIDQVWDIWSADQHGKLYVVDHNEGSKNNNNFPVAISHGIVCPGKRQIWLEGIRVHPDHRRKRIATALIAKMLQFGMRQGAIEASAVVATDNIGSRLMLENNGFSVISRWVYYASTHKTVGSSRIRHTNARVASLADLNDIYNYLTDSPIYKLSGKRYFKAWRWYFLNRRTLRHFIKKRNLIVTGYPSPNGIALINKRGYWHRRNVIQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL32</accession>
    <name>A0A6A8FL32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aliphatic sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000157">
        <property type="protein sequence ID" value="MRN68750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="357" mass="38707" checksum="2D9FBBBA147F82A0" modified="2020-06-17" version="1">MTAKIKLVISAAIIAGVIATSLLYSNPVLTISNNNNNNNSTGASSNILRIGYFPILNHAQAVIGLGNGDFQKALGANIVVKPQIFDSGPSLIEALFANQIDVAYVGPNPTINGYIVSDGKALKIISGASSGGTVFVVRNDSGIQSIKDFANRKFASPQLGNTQDVALRTYLLENGYKTKENGGNVQVISAKSSDIFTLMLKKQIDGAWVPEPWGAKLVKEANARIFLDERILWPGGKFVTALVISRTDYLHDNQGIIMKLLAVHVDETNWIIHHKAEAMQAFNTQLKKLTGHTIANEELQQASSRIDFTYDPLKQSLFKSANDAFEIGFLKKPPNLVGIYDLTLLNKVLNQKGLADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL35</accession>
    <name>A0A6A8FL35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000361">
        <property type="protein sequence ID" value="MRN69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="166" mass="18328" checksum="B165B8A663D388CC" modified="2020-06-17" version="1">MPIDPEFPRNHQVTGRHNHADGKHYHFVWGPGTPSDASSNGEVRAAYAARNEELVPVGVHGTMVAVDWDSCIADGACIQACPVSVFQWYRTENDVPAADMVNATSYGNGSTGKEERLDNTDKSDPIREHECIWCMACVTVCPPKAVKVDQANLEFHQRASETFQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL50</accession>
    <name>A0A6A8FL50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF359 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000365">
        <property type="protein sequence ID" value="MRN69239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="PTHR40732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="138" mass="15051" checksum="0061F2FD8664B418" modified="2020-06-17" version="1" fragment="single">MFLSPENLRILKEPFGLLLENKSVSKVKLYSSVKHAKLIVSVGDATTDRVTLYGIIPSVCVVDGRERRVQRRTAAGDSLLQNQVLQLRCSNPAGTISKGAVHVLRDALKASSTNPVRVIVEGEEDLLALPIFLLVPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL79</accession>
    <name>A0A6A8FL79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000220">
        <property type="protein sequence ID" value="MRN68927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="147" mass="17170" checksum="7F73D700478EA89B" modified="2020-06-17" version="1">MTSVTDRDSITINPTPRSDSKIRCCPINNTLNIIGKRFTILILRNMINGKQNRFNQFLNSIEESNPKTLSVRLREMEKYGLIKRKVYPNEKPVRVEYHPVEKGLELQPILDMMAAYSLKYCSKDVFKDAKPREFREVYGREMAKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLA1</accession>
    <name>A0A6A8FLA1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000402">
        <property type="protein sequence ID" value="MRN69303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_5" evidence="2">
        <location>
            <begin position="35"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="157" mass="17825" checksum="9D0D61BF91B300E6" modified="2020-06-17" version="1" fragment="single">MPSKNHVVILSVNNCITHIFVIMGRKLRMIKNAKYWIEKLHLSELHDEGGYFKESSRSDKIIQLELNGDRSLSSAIYYLLDGKQGQFSAFHKLGCDEMWHFYDGSSLTLYIINENADLSAIKLGHNLENGEYLEMLVKAGSWFGATVNDRSSHTLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLK3</accession>
    <name>A0A6A8FLK3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ETF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000282">
        <property type="protein sequence ID" value="MRN69067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="110" mass="12352" checksum="C1A1E4F44C63EF3D" modified="2020-06-17" version="1" fragment="single">MPIRENSTNSANESKGSYRHLYVVVEHDDGKPIPVTLEMLGEARRLMDIFNARYSSTEKVVAVVLGINIKKLCEELVYYGADAVICVENPNLRYPINLIDTKVIGQVARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLL2</accession>
    <name>A0A6A8FLL2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000221">
        <property type="protein sequence ID" value="MRN68930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="121" mass="13734" checksum="0DF6A95C64628425" modified="2020-06-17" version="1" fragment="single">SAIYYLLDGKQGQFSAFHQLGCDEMWHFYDGSSLTLYIINDNADLSAIKLGNNLENGEYLQILVKAGSWFGATVNDQSSYTLVGCTCSPAFDYRDFELAKRKELDEMYPQHKSIIEKLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLV5</accession>
    <name>A0A6A8FLV5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MoCF_biosynth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_07425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000541">
        <property type="protein sequence ID" value="MRN69513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="126"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="357" mass="38229" checksum="CED1FC81630BA597" modified="2020-06-17" version="1" fragment="single">FAVLANDIKHASDSGPITLKIVRNVGLGKVLSGVLHSGQACRISTGGYLPQGADTVVPVEYTHKSKDKVGILASLPKGSFVSPLGKDVRRDSLLLNRGNILRGQDVALLAMVRITRVPVFRKPRVAIIPTGDELTDNLNEIKSGKILNTNSHIISRLVQEGGGVSLDLGVTPDNVNKVRKKIRFALEKNDMILTTAGSSVGEYDVVEQSINSLGRPGVLAHGVKLDRGRVAGVGALKGKPVIILPGPIQGAVNAFIAFAQPLLQYLSGLPEFNGLRIAGILTEKWEARKKFKNFTKIAYVNAWLSKEGNVKATPITGETAMMTVLSKANGYLLLPEKTTTIEAGEKVYINVLPGLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM04</accession>
    <name>A0A6A8FM04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000360">
        <property type="protein sequence ID" value="MRN69227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="159" mass="18515" checksum="534174149E33E17A" modified="2020-06-17" version="1">MACRKYDETITVINTSKGYVFYREQNLQQQLVKNITGEKRILVVDDEYDTNLTLKVVLEESGFKVDSFTDPLAALRNFKSGLYDLALIDVKMPGMHGFSLSNEIRKFDIKVKICFLTAAEDTHYESFRKQAYPNYEENCIIRKPIENELLIKRIKSIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM30</accession>
    <name>A0A6A8FM30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000297">
        <property type="protein sequence ID" value="MRN69100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="120" mass="14039" checksum="6E2FAD09AA5E4D67" modified="2020-06-17" version="1">MEPQKYNFNSFYRYIIANSLFTTRQIDIISRRLENRGTIENISSGAYYRQVKQSRTKIVRLLYSIILLKCVGALDHETFFAIEKMASQIEVMFDQKTSDNSRAESVISVIEQLVKRMCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM40</accession>
    <name>A0A6A8FM40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000301">
        <property type="protein sequence ID" value="MRN69110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQ_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="entry name" value="PTHR33563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006655">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="353" mass="39063" checksum="3F5DA3A44218EEFE" modified="2020-06-17" version="1">MTDTKTKEIIVSPTVAKSKLDAFLSELKDVRILNIDPQLAPGSGFKTIFESKDADMIICKTLDELRKAKSTDKVPGFYKKVFSNEDLEEVILMSTLGAEFVIVDAPNWKIIPLENIISKLHKSGTKVYTIAKNPSEVRTMFEILELGVDGVILSTDNPKEVEVSRQYLDNPIFTIRPVKVLEVREVGSGERVCVDTASLLTTGEGMLIGSRSNFMFLIHNESEGSAFTSPRPFRINAGAIYCYTIIPGGKTKYLSEIESGTEVLIVNKEGATRRVTVGRSKIETRPLKLVRGEINGEVGTIILQNAETITFMTSDAKLIPVTEVKVGDEILGFINPKTGRHFGIEVDEYIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMA0</accession>
    <name>A0A6A8FMA0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000421">
        <property type="protein sequence ID" value="MRN69337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="123" mass="13941" checksum="3B72865F383B17D4" modified="2020-06-17" version="1">MEQVLSNLLKNSFDFVPKNNGKITIRVEDCLDNEGKITSQKEASSRFVLFSVDDNGPGITHGQIDKLFKKFYQLDTSFRRKHGGTGLGLSICKGLVEAHGGKMWYDKNYNEGASFKFTIPRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FME0</accession>
    <name>A0A6A8FME0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000451">
        <property type="protein sequence ID" value="MRN69377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="139" mass="14363" checksum="969908EE11C777CD" modified="2020-06-17" version="1">MYSNRALLFIAAAVTLSLLTTSTALTTPAMASSKGGGSVVQEQVNSGNSNLDKEINKFYNCISKTHQDPPSINKVDNCYYQALGGGGSTSNSGAMGTGTSPTSSIHHHKHGNSTSNSGVTGTGTLILPTSTSTIHHHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMU8</accession>
    <name>A0A6A8FMU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2334 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000438">
        <property type="protein sequence ID" value="MRN69360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018763">
        <property type="entry name" value="DUF2334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10096">
        <property type="entry name" value="DUF2334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="243" mass="28320" checksum="5EB10AFDD27BEBED" modified="2020-06-17" version="1" fragment="single">MTSHSMENNLAVVTLHDAAPAFSKRIFEYTDAFENLEINFNVGLIPFYHHTEDLGRFPEFVDKLKSYKRCEIILHGLYHEDRNGQMDDFHAKSKATTEEEIRAGLEIFEQVGIKTNVFVPPQWKLSSGSIEILEKLGFGLGEMQEEFFLLSQRPFRKIKVPKVLSWDLTGHPDQNIVRIGTEERRFELLDDAQRRKMIRIASHPRDPHSALKDQLEMIRKLKDQGYTITLYSDLIQKLQDVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMV5</accession>
    <name>A0A6A8FMV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_07595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="8"/>
    <dbReference type="EMBL" id="WJXC01000571">
        <property type="protein sequence ID" value="MRN69547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="7">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="107" mass="11872" checksum="7C74BD44D0B6DBEC" modified="2020-06-17" version="1">MKVKTGHASITDQDVYLLLSKIPPGKVSTYGDIAKALGHPKAARAIGRIIANNPNPISIPCHRVVKSNGEIGGFAYGEQRKREILEKEGIKFQNRIVENFEEQRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMV8</accession>
    <name>A0A6A8FMV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000444">
        <property type="protein sequence ID" value="MRN69370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="126" mass="14480" checksum="6E03B2BED3699F2A" modified="2020-06-17" version="1">MITFSTANSFHRQERLGVIKLLEASVKRSVAIGILTPVSDRIKYVTLKFLEEGHEEVEKGSQKQQIEIRYLEQSLQIKITALALADSYTGNYYSICSQRVKFQVEDMYYIYSSSIWIRKYGAVTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNF6</accession>
    <name>A0A6A8FNF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000539">
        <property type="protein sequence ID" value="MRN69510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="81" mass="9557" checksum="DC57902F22B5F000" modified="2020-06-17" version="1" fragment="single">MSQEQQRQHDQEVILWLNEITKSVWHKLHTKHTKIVIQTQEITNFNVVLSRDNEGTMKIPLIELDDVQIMNNRSVSQGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNL3</accession>
    <name>A0A6A8FNL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000573">
        <property type="protein sequence ID" value="MRN69550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="157" mass="17514" checksum="F8BAF207E9D5FA2E" modified="2020-06-17" version="1" fragment="single">KDEYLLKLKAALDARKSQDFIVVARTDACASLGLDEAINRGKTYFKAGADVIFIEAPTSTKELSKIANEIDAPLVANMIEEGVTPTLSAQQLLSMGYNIALFPLSALYAATFAIMKVFSELKKTGTTERGRRMMVTFNEFNKLVDLQKYMELERRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFI0</accession>
    <name>A0A6A8FFI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000006">
        <property type="protein sequence ID" value="MRN68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="138" mass="15261" checksum="779F4A7EEE2D21DD" modified="2020-06-17" version="1">MRLKDITKAPAKAIKRLTELGSPGMMGSLEKIKEIATTIQEIEDSLKAPPMLKNIENMTLTSEAMQNVAENIRNIRSELDATGIIEEARNTSTIVGMNSTFNKKIQNLKDLALSCKDIARSVKELTNELKLDTNKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFU3</accession>
    <name>A0A6A8FFU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000031">
        <property type="protein sequence ID" value="MRN68265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="271" mass="30312" checksum="FAAFFE512FDB31E7" modified="2020-06-17" version="1" fragment="single">MQNKLAHTSEHAFIGSLQKLMGKTLNVRKVEHRDYDNLVLITAKDIEVDSVIEAEREVNSLISQGRRVIIHSFGSLAEAKSHLPNLRANEDRIGRNNQVRVVEIEGHDLAACVMDHAANLKECGFFLITRMNRIGSDYEIDFVVSDAANNHAIDLSYKLLKICTETGANYNTVEETVKKLKQTNILHLEKLRKLTEQVLNNIEPEPTRNAGPCIISGTFTGLLDEQVREFASRKISESNLVVVLANLNSALDSMANVVFARNDSLFNIDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFU8</accession>
    <name>A0A6A8FFU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="48" mass="5314" checksum="1F141786EA738415" modified="2020-06-17" version="1">MSSFFLGGKRRGDKIFYATTIGADSYTLLMFALVIYAVGGRLCKDIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG09</accession>
    <name>A0A6A8FG09_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif5a</name>
        <name evidence="13" type="ORF">FIO02_01120</name>
        <name evidence="14" type="ORF">FIO04_01395</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">AHI_AL_Thaum01</strain>
            <strain evidence="13">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000008">
        <property type="protein sequence ID" value="MRN39635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000044">
        <property type="protein sequence ID" value="MRN68335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="Transl_elong_IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="PTHR11673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF-5a" evidence="12">
        <location>
            <begin position="68"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MRN39635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MRN68335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="130" mass="14226" checksum="58BB28F3D01A40E9" modified="2020-06-17" version="1">MSKPMDLGSLKVGSYIVIDGEPCRIVSYDHSKPGKHGSAKARVAAISVFDGSKHTLVSPVSAGVEVPLIDKRNGQIISISGKILQIMDLETFEVFETSAVEQDIIDKVRQGGEVEYWKVLDRIKVTRVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG25</accession>
    <name>A0A6A8FG25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_00855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000025">
        <property type="protein sequence ID" value="MRN68231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="154" mass="17370" checksum="61486C92272A9098" modified="2020-06-17" version="1">MGKTDDLDLKILGELATDASISVPKLSKKINVNASVVYSRIKRLVKRGLIKKFTIVVNDEALGFNVKALTGINMDSKMRDNVLNELFRIPEVREIAEVTGRFDILVTMHAQSLDEMHHLISEKVGRVEGVQKTETFIEMRKTAREIIYPTSISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG30</accession>
    <name>A0A6A8FG30_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mqnC</name>
        <name evidence="8" type="ORF">FIO04_00665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000019">
        <property type="protein sequence ID" value="MRN68194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="66"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="379" mass="42338" checksum="EAC8B20263C893C9" modified="2020-06-17" version="1">MLILQNTSGLVHDLITKSDVADILHNALDSHILGLDECIRLFKSNDIYPIAMVSNILRQRLYGNTATFVNNIILNYTNICITYCKFCAFYRPMGHEEAYTLSLDEIVKRVLVSREMFGITQVLIQGGHNPNLKLEFYEDAFKAIKTRCPEVGIHGLSASEIDTVAKVEKSSTKEVLARLKSAGLDSLPGAGAEILNDDVKAEISPLKIKSHEWLRIMEEAHELDIKSSATMMYGTVETEEQRARHIMKIAELQEKTRGFMAFIPWSFEPNKTRIQAEGLIKYSAGGLNLLKMIAISRIIYNGLIDHLQSSWLTNGIGMAQLALNYGADDFGGTLIGEEVVTATGSRSTELSAHKIIDAIKQIGFEVAERDNFYQTIKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGA1</accession>
    <name>A0A6A8FGA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_00975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000029">
        <property type="protein sequence ID" value="MRN68254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="145" mass="15433" checksum="9949431F3E4421E8" modified="2020-06-17" version="1">MLIESLPTHDNALHEIRLRFSAEGLHVSRILYVVIYILAGIAGALFRGVIASYILGGGHALLIGASGAISVVLGIASPAGNTRAYHWLILQIMVAVFGSIASIPIAFTAHIGGFAGVFLTKLFVGIERKKRAKYSRPSGNNTYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGD5</accession>
    <name>A0A6A8FGD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14p</name>
        <name evidence="3" type="ORF">FIO04_01180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="37" mass="3858" checksum="7DC693D0940D15DB" modified="2020-06-17" version="1" fragment="single">VLVTPEGEIKGTDIKGPVAAEAAEKWPRIANLASLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGJ8</accession>
    <name>A0A6A8FGJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isocitrate/isopropylmalate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000004">
        <property type="protein sequence ID" value="MRN68106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="341" mass="38022" checksum="B48F97D655F6653F" modified="2020-06-17" version="1">MSKKTAAIIRGDGTGPELVEAMIKVLRECNTKIELIPCDAGSEWWQKVGGTSYISQDVWKLLEDSDACFKGPTTTIPNPNAPRSVAVSIRQKFELYANVRPIKTYKNAERRLYFICVREATEGLYAGIEFKTSDDSAIAIRKITRKGCERVTKKGFQIANDAGFKKVFAITKRNILKETDGIFWAAVEKTQKEFKTIELEEYYIDNMTQQLVKNPERFNNSVLLSTNLFMDIISECASGHVGSIGTVYSGNYGDHYAMFEPAHGSAPKYAGKNMVNPVATILSGAWMVEYLGEKHISKAIFKATEDVINENKYVTYDLGGNATLSQMTDLIATKAGKLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGL4</accession>
    <name>A0A6A8FGL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000053">
        <property type="protein sequence ID" value="MRN68381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MannoseP_isomer" evidence="1">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="119" mass="13990" checksum="5AB7C927CE4C1202" modified="2020-06-17" version="1">MDIYSEDRPWGSFEKFHENEQCTVKLIYVNANSRLSLQYHSERWEFWKIVKGIAEVQLEEKLLILKEGESIVIPMGAKHRVKAVGGQCIILEISYGRFKEDDIVRLEDDYRRTSTKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGN0</accession>
    <name>A0A6A8FGN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrite/sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000056">
        <property type="protein sequence ID" value="MRN68401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="75"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="212"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="491"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="646" mass="73985" checksum="E24ADA3DDB23A590" modified="2020-06-17" version="1">MFKQAVNPNFRTDTKDYSRVEVAKINSNELRGNLFNEFRNHSSENISWESEQIAKSHGIYLEFNRAKTGNEKDWMYMFRITLPGGGPITAKQWNILDRISDSYTIGPENAYPHARPGLKITTRQNIQLHWVKKINVVDAIRDISESGFFTMNGCGDNTRNVIGCPLSYHSTIFNANTWAQRVGKYFALPTAAYIEIFEIDPKYLRDGDLENRIPGVSRFDYGQNQLNRKFKVAFSAIHYDDVNKKYVPDNCVELRTNDIGIAPVIKSDGSGSAKVEGFQVYVGGGQGQQSGKPTISALGEPFGLFTEENLMKGLDAIVRVQKDWGDRHNRHWARLKYLVTVKGIEWFREQVRNLDGIGSINFEPHIEDYDYGNIDLHLGWVKQPDNSSRWCYGAFIENGRIIDGSHNGDLKSMVKYLMNNYPHIELFTTPNQHLMFCNIEEGLKELFERDMKMFGYGFRKINSDSNKDSIPDGKTALHRAYSNLRKSSGACVGRDTCRLTYTDSEKFEPYLIDELEKKWGYMTESIGVTGCEKQCYRPATKTIGWIGTGFNLYQVVLLGTQDGRHQGRILVDPYSGEQYLHFVPRKDVATITDALFEYYVRNRSEEEDRPGGMGYFNRRVGPREIISYLKSNPKTADLMKKTFKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGP7</accession>
    <name>A0A6A8FGP7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl11</name>
        <name evidence="8" type="ORF">FIO04_02785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000111">
        <property type="protein sequence ID" value="MRN68605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="6">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="160" mass="16558" checksum="740721BF20D11103" modified="2020-06-17" version="1">MGDKKTVSALVNGGEASAGPPLGPALGPIGVNILQVVNTINEKTKDFPGMKVPVKVEVDTTTKQFTVEVGVPPTAALIIKESGVTKGSGTAGTNYAGDITMETAIKIAKMKIDSSYANDIQGAVKEVIGSCQSIGMTIEGKPAKDVYSEVSAGKYDEHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGP8</accession>
    <name>A0A6A8FGP8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glutamine synthetase</fullName>
            <ecNumber evidence="2 5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnA</name>
        <name evidence="7" type="ORF">FIO04_01845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 5"/>
    <dbReference type="EMBL" id="WJXC01000060">
        <property type="protein sequence ID" value="MRN68421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="119"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="488" mass="55230" checksum="5196B5F69B6FF855" modified="2020-06-17" version="1">MPYKVIDGKIEPLSFTAEEVMQKLKNERIKFLDLQFTGLTGRFHHTTMASNMFHKEDFEDGLPKLDGSSIRGFTEIHESDLILRPDPSTYATIPWIEKDSTARLICDILTGGSERNPFPRDPRGIATKAAKYVREKGYESSFWGPEVEFFVFDKLEVNTMTPYHGQSYNITSREAPWSTEGVGYFLRLKEGYLPSAPGDTLMDYRNECVDVLSNDFGIICDTHHHEVATAGQCEIDIRYDTLVNAADSVQSYKYIVKNIAKKNNMIATMMPKPIALDNGSGMHVNVSLWDKQKNLFFDDRDEYAEMSETARYFGGGIIDHAYALAAIVAPTTNSYRRLVPGYEAPVYIAWSRGNRSAIIRIPAHYKGRKFAAMKRIEFRAPDPSCNPYFAFSAMVAAGLDGILKKKPLGNAVDEDIFKMTPQRRRELGVKQLPASLREAYEALDSDRAFLKPIFGDDAIDSIIEHEVKEHNEVAVRPHPHEFSMYADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGQ6</accession>
    <name>A0A6A8FGQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000114">
        <property type="protein sequence ID" value="MRN68615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="341" mass="37539" checksum="4769DF56B9C649E2" modified="2020-06-17" version="1">MGRYNVALIAGDGVGPELTSSAKMILETINDNSNIKFNIRNVDAGDRALAKYGKALPQFSSDVIQKSQVCLKGPVGESAADVILVLRRQYDLYANVRPAKSYPNIPNLSANVDLVIVRENTEDVYLGWEFDADENTVVGLRITSERASRRIAEYGFKTAMLRNKKKRLVTAHKANVLRKGDGLFARTCKSVAQNYPEIIYSESYVDTCAMNLIRNPEEFDVILTTNLYGDILSDEAAQVVGGLGLGPAANIGESFALFEPVHGAAFDIAGKNIANPSSILLSIKMMLEWLSDKYHDRGAFKEGQRIESAMVVLLRKNLKTKDIGGKLTTTEFTKLLSLSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH18</accession>
    <name>A0A6A8FH18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000087">
        <property type="protein sequence ID" value="MRN68524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="205" mass="23453" checksum="A0A3865C073F5383" modified="2020-06-17" version="1" fragment="single">RKVILTSGYIERFNPAIQDVKQLIDNHKYGDLLMMEFHRENRMPLHIRDVGIIYDTSVHDIDTAMYLFKSTPHVVFARSGTKFHSYEDFATIMLGFDEQRVAIIASNWITPNRVRKFSAVCTEGIITGDYITQRIKIDYEEATIIPRRGKFKEPLTLELQSFLDVIAGKIREPVVTPEDARNVTKVAEAALLSSNTGSPIYMDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH39</accession>
    <name>A0A6A8FH39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000092">
        <property type="protein sequence ID" value="MRN68544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="60" mass="6681" checksum="4F566FE7E5CD9862" modified="2020-06-17" version="1">MKVLGNWFTTSMGVCKMAPSSQHVKKSAQQIILFDSFNNKNLVSTVLATHAKLEILYPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH86</accession>
    <name>A0A6A8FH86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_02915</name>
        <name evidence="3" type="ORF">FIO04_00380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000073">
        <property type="protein sequence ID" value="MRN60996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="58" mass="6707" checksum="5CDDF1F0C23A9020" modified="2020-06-17" version="1">MLENISLVMYFIIGYAITYLALEIAWHFTACRLSDKTIKPCLFKQVKMVMTAERGYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHA3</accession>
    <name>A0A6A8FHA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1697 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000110">
        <property type="protein sequence ID" value="MRN68604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="185" mass="21182" checksum="F246F03BF702D6A5" modified="2020-06-17" version="1" fragment="single">QYVAFLRGINVGGHNLVKMEDLRQMFLSLGFNNVRSYINSGNIIFETSEIDSNAIIKGIHRELNELLEGDVKVFLRNMSQVEEIIELNPFKDIKSQTTKLFVTFLSEEPSRKIRPPLNSPDMDVEVIFMTNREAFSLAHRKNGRFGFPNNFIETRLGVSATTRSWTTVKRIAKDATTNSTIHFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHC8</accession>
    <name>A0A6A8FHC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000018">
        <property type="protein sequence ID" value="MRN68188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="112" mass="12777" checksum="EBAA9E999895D928" modified="2020-06-17" version="1">MHCGIDTRMHPIINSKDVNHCTALGDGLLNKKIVLSFGHKEKSGKSNESHSNYLDYYVFNLNSLDELNRIRKDNADYPIGTSLDYCPYCGYGYSFNSEIQNTNFLIRSNYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHF0</accession>
    <name>A0A6A8FHF0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="7">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asd</name>
        <name evidence="9" type="ORF">FIO04_00860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000025">
        <property type="protein sequence ID" value="MRN68232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="358" mass="39759" checksum="CBFA15C246510BFF" modified="2020-06-17" version="1">MLKVALIGATGAVGQQFVLALNKHPWFELTQIVSSERSAGKKYMDALRDPKSGILRWHSKETIPEYIRDVIISRVEDISPKRFDLIFTALESEDAKVIEPQFAKSVPVISTAAAFRYEEDVPILIPGVNDQHAELLNTQRKNRGWQGFIAPLPNCTTTGLAITLKPIMNEFGVEMVFMTSLQALSGAGRSPGVIALDIMDNVIPYIPKEEEKVQIESKKILGDVNSRSITPATFKVSCTCTRVPVLDGHTEVVFVGTKRHCEPEDAKEQMLKFSKSVAVKKLPTAPKDFILVHDDPTRPQPRIDREINDGMTTVVGRLRQDTVFSNGLKYVLLSHNEKMGSAKGAVLLAESLKDRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHH7</accession>
    <name>A0A6A8FHH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000215">
        <property type="protein sequence ID" value="MRN68915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="82" mass="9874" checksum="6A95B6071B1C3F9B" modified="2020-06-17" version="1" fragment="single">MKEDEIIVQVQKINSEFYHAFENLSIERMEGLWKHEDSVVCIHPGWDLFTGWLAIRESWITIFRNTEMIKFIITNTKVRVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHI2</accession>
    <name>A0A6A8FHI2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000219">
        <property type="protein sequence ID" value="MRN68925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="577"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="803" mass="90420" checksum="9C128DEEE1800C5F" modified="2020-06-17" version="1" fragment="single">KYHGEVEYKVVNPHITRLYVVPSANLPLYNEIIYITSDAPYILTWAGTFMLLRYYYKRTGKLNLKFWLILSIPLILYLIGSGLIFSLPANIPYKFYYRLIFRAGTIGSSVLFGLAFYVVSRKLTAARIKDYLAISAMGIVPIGIANEISALQQTYGVAAHSLVLLASYLFTIGLYSLVISISQDSSLRKSIRNSALEVSKLADVIEGPGKEQEIERRVLTSAKEQEEMLIQETGVRSSLTDHEMKQYLGTVLKEIKILKNVDEILKKGKEILESSFEFLVCSRFGGLRLVYNNYLDMYAKVLDKYKKKEHKGIRMVTSITDKDSANLIRKFLEIGVHVRHAKNMPPIDFAVSDKEMIATIEKAEGGEENIKSLLVSNEYPYITHFVSIFEELWKDGTDAWDRIKTIEENIEPEIFEVITDPLKASQIIVELAKSVKLEAVFLLPADRSMKRVDRLGIIDHLIKASQNGATVRIICPLSEENSDIVKRISTSAPNIRILNGHNSTSGFLIVDSARFIRAELRESSAKEFAEAIGFTLYSNSKGSVDSFKSVFDLLWNEHMINEQLQKADEMQKEFIHIAAHELRNPIQPILGLSEVMRSKITDPEQIGMLDVTIRNAKRLRRLTEDILDVSKIESQKPLQLNKEKFNLTEILLNTVADFKNEISIDNDDNNNNSKNINPSIKLELLSSERDVIKVEADKSRINQVITNLLSNAVKFTERGNIIITTQKTTDGLVIIIFKDAGSGIDPEIMPRLFTKFATRSNTGTGLGLFISKGIVESHGGKIWAQNNLDGKGATFSFSLPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHK7</accession>
    <name>A0A6A8FHK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged helix DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_01050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000031">
        <property type="protein sequence ID" value="MRN68268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="183" mass="21120" checksum="4FC4B73E6F1D194B" modified="2020-06-17" version="1">MNPWHIPRSVSLKAIYTKKVASTRRTSSVKNERRKQDEEELYIGTAESEHIEMYLKALWYIVEKGEEPKISSIAKLLNIRQPSVVEMLRKLNEANLVEYERGSIVRVTSQGNNIGRQMIRNTRLLEVMMKYALKIDIDEEMACGIEHHMNNEFTDALCTLLKHPRKCPHGHNIPAGKCCNRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHM8</accession>
    <name>A0A6A8FHM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-histidine N(Alpha)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">egtD</name>
        <name evidence="4" type="ORF">FIO04_01150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.44" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000035">
        <property type="protein sequence ID" value="MRN68288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030745">
        <property type="term" value="F:dimethylhistidine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="3">
        <location>
            <begin position="15"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="328" mass="37831" checksum="09EF0D2BA2807783" modified="2020-06-17" version="1">MYNTSEPQLDEGFVRNIKEGLGARDQKRVNPKYLYDSAGSQLFEAICRQPEYYPWRTEAAILRQHSTEMVWMHGKKKISIIELGSGSSSKTRILLQKVLLRQPSLYYFPVDVSQAMLRETIYNLSADFSSLRTIGISSDYIDGIDKANSLIAADRQIPDKKLIIFLGSSIGNFEPNESVAFLRNLRSKMEESDDLLLGIDLHKNKNVLEAAYNDKEGITARFNLNLLTRINRELRGEFNLDSFVHHAFYNSCYKRVEMHLVSTKDQQVYVGRLGQTFSFDKNETIHTENSYKYSAEEIKQMAEDSQFILKRNFVDEKKWFNVALFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHN6</accession>
    <name>A0A6A8FHN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flippase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_00020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="363" mass="39446" checksum="C93C70BB82B931A5" modified="2020-06-17" version="1">MNWRLLAIPASIVPLLIMIFSTHVSPTNIFAVGVIPFVMSSVSVIGRIMLQALRFDYFIRKFIGPNVSSTGKIISARLAGEFITQTTPSYVGGEIVRIAFLTKNGVPAGNAAWITTMEIIADVFVGTILAFIAGALAIYKGGDFIGIAVILVAVPTFVFWLLLVVFSAKRTLRLPSFSLKVLQKFIAKQKAERLINTTNTAIFDLCKMSRQNFNSVRAVKIFAVGIAITFMAFLLQGASFLILANAVGFRLGVFDSLMATSASTALSTLPITIGGSGLAELGIWAYTSHFTGIPSFANVVNDSHLSLIIAWRIASYHVPLLIMWVALMKLTMTKISIKSLTKKNNLWDVTHKTSTDETEGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHQ1</accession>
    <name>A0A6A8FHQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_01310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000041">
        <property type="protein sequence ID" value="MRN68318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="378" mass="43352" checksum="3D424BA760822A2E" modified="2020-06-17" version="1">MGKFLGRKPKPRSNPASETTNHVNYDDNSEFQKRDLYQKGVNQMASEKLEDAIRSFDLALRIDPKYVDSWIKKGYAHFHLAQYPVAISSYDKALDVDLNNGEAWNLKGLAYYRMNNYEKAVAACEKAIDINPNDGMSWYNKACYLTVVGKVDEGMEALKRSIEIDISYAKRAVRDRDFENAKAEEGFRRIIEVVVLESIRQGYNHVGKIVWVTGMDKSEVEDAFMRLSMKGLTVRKERKEIHGFFTSKEEYYELVKEIADKVGVAKRVGFFGHSKEVSAPVQQLRDIIEVLGKAKESIEKGDVNATIECFDQLINPTKHGTAMIEQFFDEHRDLRLFQIRLKDKGHEYLNSHKPDMTKLITDIEAKMRTGPVSRSAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHQ3</accession>
    <name>A0A6A8FHQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000245">
        <property type="protein sequence ID" value="MRN68985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="104"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="450" mass="49331" checksum="BBCBA7B4058EEE3D" modified="2020-06-17" version="1">MANIEFIIPSVLNKGTGEKKISLEAHDLHEAFAKVSDILGDDFKRRVFDLNGKPRALINIYINGRNMRFSSDGMSTLLKDGDSLYILPAVAGGTELTNEDMQRYSRQIMLEEIGFVGMEKLRDAKVCVVGIGGIGNPVVTQLAAMGVGKLKIVDRDVVEISNLHRQHLYNEDDIGQVKVEVAAERLKKINPHVEIEAIPLSITKYTAESIVKGMDIIIDALDSVDARYALNDACIKYNIPFIYAGALGMLGSVCTILPNKSACLRCMFPALAEEDMPTCSTEGVHPSILYLVAGVQVSEAVKIVTGQHPTLVNKLLYIDLNELSFDKIQMFRHEECSSCGPKKESKKEVVLQQEELIIEELCGRDRGKRTYTVSPSSTPPASINLTGIVKNAESLGYDVKMRGNLGITAISTNPNKLSISFLTSGAATIVGAKDEEDALFIYRTFAKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHR5</accession>
    <name>A0A6A8FHR5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_03685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000167">
        <property type="protein sequence ID" value="MRN68781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="153" mass="16548" checksum="0ECABC413DF7EEE6" modified="2020-06-17" version="1" fragment="single">MFEKMQALIDIVKKKGIVVDDITLSSGEKSEYYYDLKNVSLDPEAINIIGDLLLEEIVLKYGKVKSVGGLASGAIPLVTAVVMKSSNNVEGINGFFVRKERNPHGLQKIIEGKIIPPVVIVDDVMTTGGSIRLAIDAVREGGFNVEGVFTVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHV8</accession>
    <name>A0A6A8FHV8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 1-alpha</fullName>
            <shortName evidence="5">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor Tu</fullName>
            <shortName evidence="5">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">tuf</name>
        <name evidence="7" type="ORF">FIO02_06785</name>
        <name evidence="8" type="ORF">FIO03_04815</name>
        <name evidence="9" type="ORF">FIO04_01640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000119">
        <property type="protein sequence ID" value="MRN40729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000149">
        <property type="protein sequence ID" value="MRN61363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000053">
        <property type="protein sequence ID" value="MRN68382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN40729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN61363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="437" mass="47577" checksum="A9886D58FD249146" modified="2020-06-17" version="1">MSASKKPHMNLVVVGHVDNGKSTIVGHMMVDLGVIEQRTIDAFAKESEATGKGDTFKYAWVLDSIKDERDRGITIDLAFQKFETQKYFYTLIDAPGHRDFIKNMITGASEADVAILVVSLKPGETEAATEPGGQAREHAFLARTLGVGQMVVALNKTDDVGYAEARYKEVKDIVEKMLKLVGYNTTKINFVPVSGWKGDNLIKKSENMPWYKGPTLVDALDMFDPPEKPIGKPLRIPVQDVYSITGVGTVPVGRVETGRVKANDKVIVMPSGITGEVKSIETHHTQMDSAEAGDNIGFNLRGVDKKGIKRGDVIGPTDNPPTVAKEFEAQIIVIHHPTAMAPGYTPVLHAHTAQVAATLSEFLAKIDPKTGGTVEEKPKFLKTGDAAIVKIKPVRPLAIETFKEFPEIGRFALRDMGTTIAAGVVKSITEKYDPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHZ7</accession>
    <name>A0A6A8FHZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000285">
        <property type="protein sequence ID" value="MRN69075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="2">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15292" checksum="93A44DD4047977C6" modified="2020-06-17" version="1">MVVEQTLIVVKPDGIKRQLTGRILARFEEKGFQIKNITSFNFTLEKAQEFYAPHRDKAFFNDLVKFISSGLVIACILEGTNAVNTVRLMIGATKSFEAAPGTIRGDFGIGLTDNVVHASDSYESFIKESRVIFDRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI25</accession>
    <name>A0A6A8FI25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrroloquinoline quinone biosynthesis protein PqqC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000201">
        <property type="protein sequence ID" value="MRN68881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="15"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="218" mass="24856" checksum="5AA3158EE63DBDAA" modified="2020-06-17" version="1">MTGVVERIDIEIEKQSLLKHPFYQMWSEGKLTADHLQGYIKEYFQLVITVPEFVRNIQGLTNDSSLETELAHHFKEESDHIEAWMRFAISMGVSRDKLLNHAPTCKTTEAVLTLNSLTKLSFEEAAAAMYGYEKELPKISTSKINGLKKYYGIVNSDATNYFEIHEEADIRHARLWMNILKNVSTADTESVLEAGVKSLSAQNKLLDSIQEKYVGQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI45</accession>
    <name>A0A6A8FI45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000071">
        <property type="protein sequence ID" value="MRN68462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="127" mass="14161" checksum="9B984DBA752567B8" modified="2020-06-17" version="1">MPRVIHFEIVADKPERAMKFYKEVFGWEFNKWNGPQEYWFVKTGEDSQPGINGGLTPKMNQESGDTSGRVTNTIDVPSIDDFSKKISTEGGKVVRPKMAIPGIGYLAICEDTEGTSFGIIQNDQNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI48</accession>
    <name>A0A6A8FI48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03557 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="328" mass="36990" checksum="323E7A81B6032BDF" modified="2020-06-17" version="1">MVRISVQAAHEQVNPIDLLDDVINMDQNGIERCWTSDHYMPWWNSGASGGAAWPWLGAALAKTTKIVIGTGVTAPILRYHPAIVAQVFATLGYMFPNRVFLGIGRGEALNEVTSGHRWPSNIEKFRRLKEAIHLIKKLWIEDWVDFRGDYYWVKDSRLYTKPIRPIPLYVAGLGEQSARLAGEVGDGFVTNELNVEAIRNKLLPAVKAGATNSGKNYDSLDKILFIPASYDEDKQKALESIRFWRGAMIKAFFDVDVHDPRKIEENGQIIGDDTLEKMLVVISNAEEGIKKLQKYIELGFTEIVLTNSSPERHRLVKLIAEKIAPNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI49</accession>
    <name>A0A6A8FI49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000213">
        <property type="protein sequence ID" value="MRN68911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="2"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="209" mass="23141" checksum="60F8221489CB38B1" modified="2020-06-17" version="1" fragment="single">INCGQSCIASKRFIVVKKVANEFIEKFAQKAEKLKVGDPMLEDTDMGPLVNADGLNKIDSIVKDVVKEGAEVLTGGERIKSKGYFYKPTVLKNVSPKMRVAQEEVFGPVAPIMVAEDDMQAIKLANDTQYGLGASIWTEDLDKAEKFSRMVQSGIVSVNNIVASDPRVPFGGVKKSGFGRELSRYGMLEFVNIKSVRFYDQLVHQHHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI81</accession>
    <name>A0A6A8FI81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_09040</name>
        <name evidence="2" type="ORF">FIO03_07855</name>
        <name evidence="3" type="ORF">FIO04_01000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000210">
        <property type="protein sequence ID" value="MRN41173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000331">
        <property type="protein sequence ID" value="MRN61936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000029">
        <property type="protein sequence ID" value="MRN68259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="52" mass="5850" checksum="EB8BB5836762F4CC" modified="2020-06-17" version="1">MVQLKEFVGGNIVGSGSNYVVVQKDSKRFFIELKDYSVLELKKSTTPYGSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI90</accession>
    <name>A0A6A8FI90_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000082">
        <property type="protein sequence ID" value="MRN68508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="223" mass="25081" checksum="B820D50460D9CCB2" modified="2020-06-17" version="1" fragment="single">SKSKYIGDVVSMFDERLYKRWDKLSQALKTNKPIEEKQVADIESLFDKAKSNQEVEQVQKFTHAMYGISIGPAMALAKNVDFSNHKKMMDIGGGSGVYAIQVVANSPNNMSAVVLDSKPVCQVADRYIQQYDLQDKVQTVTFDFFKDRLPENGTIIISEWLLNDEKTGPIPSALMGLTMIVENSGGRGYSYNEILQMLTEVGFKNIERRPLIEPAEIVIGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIC4</accession>
    <name>A0A6A8FIC4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps8</name>
        <name evidence="5" type="ORF">FIO02_11785</name>
        <name evidence="6" type="ORF">FIO03_04100</name>
        <name evidence="7" type="ORF">FIO04_01205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000370">
        <property type="protein sequence ID" value="MRN41704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000119">
        <property type="protein sequence ID" value="MRN61224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_S8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN41704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="130" mass="14805" checksum="255A7F7AE5E6817E" modified="2020-06-17" version="1">MPALNVLSNLFTTIYNNESRRKKECIVIPASRFSSDILRVMQKHQYIGEFEQIDDGRAGKFRIQLLAKINKCGIITPRFSVKKNSYLNWERRFLPAYNMGLILVSTSAGILSHHEAQEQGIGGVLIGYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE8</accession>
    <name>A0A6A8FIE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000256">
        <property type="protein sequence ID" value="MRN69011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="337" mass="35519" checksum="91F7454B313B06F6" modified="2020-06-17" version="1" fragment="single">MMILLSVSILVLLISQYVTNGLVGVVTAFSTIQERHRVPGSLFVYSNTLQLAVQSQLLPFHQSSIQNSDIHYVSLANLTASPLLTDIFKRVENSVVQITSRVNDTGDLQIIINGNPLQGPSTRLGSGFVYDNQGHIVTNNHVVNGAKTVDVTFVDGNTYTAKVIGTDPSSDLAVLQITDNFSVEKVVPLIIANSSSLQVGQQVIAIGNPFGLSDTMTTGIVSQTGRLLPNPDTQFGIPNGIQTDAAINPGNSGGPLLNMQGQVVGMNTAISSSTGEFSGIGFAIPSNAITRILPSLIQTGTYTHPWLGISGGSLTPALARNAGLPINYKGVLVRSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIG7</accession>
    <name>A0A6A8FIG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000161">
        <property type="protein sequence ID" value="MRN68756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="82"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="175" mass="18826" checksum="C10227BA39778AE0" modified="2020-06-17" version="1" fragment="single">MTLSVGLFLIGILGLSCLSTSIFKQQNQALAQQYIQTIKYRNLVIDLGNGVKTNAQLTLPALGKGPFPGVLLVPGSGATDMNEHVGKNTAPFLQISQYLSERGFAVLRYDKRGVGANGTILDSNVWGNTTFTNLKQDAEKALAVLIKQPEVDRSKITIIGHSEGTMIAPRVAIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIH8</accession>
    <name>A0A6A8FIH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TfuA-related McrA-glycine thioamidation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000104">
        <property type="protein sequence ID" value="MRN68582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012924">
        <property type="entry name" value="TfuA_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07812">
        <property type="entry name" value="TfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfuA" evidence="1">
        <location>
            <begin position="53"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="227" mass="25940" checksum="C76195991260512E" modified="2020-06-17" version="1">MNKPIVFIGPSLAIEKARKIFNADYRPPAKKGDFLRLLACINDDDRTIVGLVDGLFLQDYPPTPIEVFQLLIKKNILVLGAASIGALRAVELEKYGMIGIGKIFELYKKNKIAADDEVAVTFTEETQHIQSEAMIDIRYNLFIALRKGVIDENAKRAAVKVAKSMYFPDRNYEDIIDETKRRHPSLSDYLESFRSYISKNRQSLKEQDAIKLVNYAKMKYEGEITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FII2</accession>
    <name>A0A6A8FII2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl24e</name>
        <name evidence="5" type="ORF">FIO02_04860</name>
        <name evidence="6" type="ORF">FIO03_03635</name>
        <name evidence="7" type="ORF">FIO04_05170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000068">
        <property type="protein sequence ID" value="MRN40356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000099">
        <property type="protein sequence ID" value="MRN61132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000285">
        <property type="protein sequence ID" value="MRN69074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023438">
        <property type="entry name" value="Ribosomal_L24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="PTHR10792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN40356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="70" mass="8055" checksum="C32B670D9D3A9FC4" modified="2020-06-17" version="1">MSKTATSVRNCFFCGRHVTTGQGTMLVKNDGSIQWTCSNKCKKNLRKLKRDPRKFKWTTKYVKGGIKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIJ9</accession>
    <name>A0A6A8FIJ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000285">
        <property type="protein sequence ID" value="MRN69071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_III" evidence="2">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="1">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="183" mass="20392" checksum="FB8AFF0DE227AADF" modified="2020-06-17" version="1" fragment="single">HKGADVVCPINSTMAVSIVANEAGSKVIHTKVGSVEVSREMVKRKSIIGLEENGGFMYGKLNEVRDGVMTTALVLDMMATENQTLSTLMSSLPKIFQYKAKFRCNKQKANEVVQSCLKHGSFQNVETLDGAKIWIDKETWVMVRPSGTEPLVRMYAESTDEMLLNSKVREYRRLIEGTINCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK8</accession>
    <name>A0A6A8FIK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000379">
        <property type="protein sequence ID" value="MRN69265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="291" mass="33791" checksum="EC5A9F49E74EA7A2" modified="2020-06-17" version="1">MHSDDANLTNSRSSSRHIESTQRIFFELASDQRLSILFKLNRQQSEAGVYNLSKLAKHLNVTMQEVHRNLNRLMDAGLIEKDSAGIFSLTTFGNTIINQIATFDFLSRNKEYFSTHTFGKETRMKFIQRIGALNNCEFISGLVAVIELWKQHIYREATEYIYGMLPQIPLDLIEAVIPKIKEHGGIKFNYILPQKAMVPKKRTELLKNAGFHEFIKKGIVERRMVDRIQVAIVLNEKQATVMFPTAKGQGETDMNSVFYSEDPLFHEWCLDYFRYNWYNSKSFDESKLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIM8</accession>
    <name>A0A6A8FIM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltX</name>
        <name evidence="7" type="ORF">FIO04_03860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000178">
        <property type="protein sequence ID" value="MRN68816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="6">
        <location>
            <begin position="111"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="444" mass="50289" checksum="14E2098705B2EBE4" modified="2020-06-17" version="1" fragment="single">MTSSSSYSVDEGTRNFIKIIVLKNAIQYGGKARDETVISKIIAQRPDLRSNLKILIPEIKITLEEINALTLDEQKALFARIAPHESAAKKKGTADHDANLPALHDAKMGNVVTRFPPEPNGYPHIGHAKAAIIDDEYARRYNGKLILRFDDTNPLNEKPEYYDAIREGIEWLGIEPDIVKNTSDDIQLLCDYGKKLVELGGAYVCRCTQSVMRDLRSKGLACDCRTDAKNTQDLLRKLFDGSFEPNTAVLRFKGDMDDQNTAMRDPTLFRIIEGHHPKLGNSNRVWPTYDFAAPLEDSLDGVTHALRTKEYELRNALYFAILDRLSLRKPSMLEFSRLEFEGMPVSKRKIKPLVEKGLVQGWDDPRLPTLAAIKRRGFLPQAIRKFVLSLGLTLSETKPPFEALEAFNRKIIDPQCIRLFFVKDPIQLQVRNAHPKEVTLSNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIP4</accession>
    <name>A0A6A8FIP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000058">
        <property type="protein sequence ID" value="MRN68409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="201" mass="21279" checksum="C5F3377C627243C6" modified="2020-06-17" version="1">MTTTNPPNSNNNNNKMNSPRWLQFLEVGLGAIAIIITIVTLTYPGITTQTIIRLVSIVLLIIGFERIAIGIAFPSPSKSYRLANIGLGPLIIALAIVLIAFPQSQPVPPIALGALALLFNGISKIVQGTRGKEIPSWSKGILVGVGTLNIAVSVLAIMLPNLHASALARSVSITLLITGIQMITSGIGIKKKYRKSHASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ8</accession>
    <name>A0A6A8FIQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000403">
        <property type="protein sequence ID" value="MRN69305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="92" mass="10758" checksum="80D66230BAEF0A15" modified="2020-06-17" version="1">MKVVKILSKGDVYVSHDGKFWPCCGMHLWLSPAGKKYRGRLRQIRNLEQLTQIQLVLEKTKQQSRNNDDSALDTSSDQFLKQIDYDCMRAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS6</accession>
    <name>A0A6A8FIS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000140">
        <property type="protein sequence ID" value="MRN68698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="74" mass="8293" checksum="45FC34613E1DC5AD" modified="2020-06-17" version="1">MSVVSQSGELESILQVKNVSKVYSKNTTASDHLVLNNLNIDIKEGEFLDIKDHQTVVKHFDLPGLQFLKVLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIU2</accession>
    <name>A0A6A8FIU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000428">
        <property type="protein sequence ID" value="MRN69345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="102" mass="11197" checksum="B8E26C6E4DE89146" modified="2020-06-17" version="1">MLQVFIADVNSQLKFNQGGIVKAISIVIYHNFVTYPDITNSKDAADTTVNLFDEEMKYLHDNGFKVLTLNQIGYDTTHNVLDIKNISPGSSGRIVSGTTTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV1</accession>
    <name>A0A6A8FIV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMP dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000342">
        <property type="protein sequence ID" value="MRN69194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="57" mass="6233" checksum="7E4FCB6A73DD1184" modified="2020-06-17" version="1" fragment="single">MQIKDGLTFDDVLLVPKRSAVISRSQTDLRTRLSTNISLNIPLISANMDTITEAGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX1</accession>
    <name>A0A6A8FIX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000359">
        <property type="protein sequence ID" value="MRN69224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="113" mass="11135" checksum="53A34740350F4BFC" modified="2020-06-17" version="1" fragment="single">MIKVKVATGLLVASAILLIIYGADVAVSSSGLGSPSHSGFLPINKAARGGVFGGGAVIMSIIGFVITLGDPSQVIAMLLIINGGIIIAGMIILIAEGSGTTRNATITISSTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY5</accession>
    <name>A0A6A8FIY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PhoU family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_03135</name>
        <name evidence="3" type="ORF">FIO04_00475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000035">
        <property type="protein sequence ID" value="MRN40023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="235"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="343" mass="38549" checksum="CDA3DDF31E9773AD" modified="2020-06-17" version="1">MSLPKRWMNEMHLKPGDPVTIIRESNNSLSIVPNAVRSPSSNNEVTALMLQDESGNSLKRKVVSMYLAGYNIMHLKSKTGRINSSQRDAVREVVRRNLVGTEIIADASDLITIQVLLNLPELSVNTAVRRMFLISTAMHKDAMASLAEQSYDLARTILKSDDEVDRFSLYILRNLVMATKNERMLQEIGLRGPSDSLSYRVAVRSIERVADHAAGIADKCLNITEKISKEAFQKLDKMSRISLALLNDSVEAFLRRDYYLADSIVDKTEGIRSLENEIILFLDKEKASSSTLHESTNVYIKLILEDIRRTAEHASDIAEAAMNETVSEVIEKIPSRERKVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ06</accession>
    <name>A0A6A8FJ06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_02210</name>
        <name evidence="4" type="ORF">FIO03_09890</name>
        <name evidence="5" type="ORF">FIO04_03720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000021">
        <property type="protein sequence ID" value="MRN39843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000543">
        <property type="protein sequence ID" value="MRN62332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000170">
        <property type="protein sequence ID" value="MRN68788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN39843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN62332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="81" mass="8610" checksum="8621EA40B8D6852E" modified="2020-06-17" version="1">MGYGRSYGGGGSRDFRGSTGPKPVEVGKEYDIEVTEISRQGDGIARVQGFVVFVKNGKVGQKVKVKVDQVGNRFATATVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ47</accession>
    <name>A0A6A8FJ47_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_00355</name>
        <name evidence="3" type="ORF">FIO04_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000005">
        <property type="protein sequence ID" value="MRN60495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000080">
        <property type="protein sequence ID" value="MRN68493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="56" mass="6894" checksum="D2D81EB06CB9AC00" modified="2020-06-17" version="1">MIKTAEAKSDGIIETPQEKRERFLMEFEKPFKCEKCNERFKKKKYLREHKSQIHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ53</accession>
    <name>A0A6A8FJ53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000403">
        <property type="protein sequence ID" value="MRN69304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="99" mass="11965" checksum="E1A768290D108C1E" modified="2020-06-17" version="1">MTKQYRMLIVYNHTEKTLDQEKIRQHMEFAGFHIININMNPPMGSKQNTEIYYESDIPFPFTYASYMIREQNLDTEVAFLQEVQNQDCTWENIKRTLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB0</accession>
    <name>A0A6A8FJB0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000441">
        <property type="protein sequence ID" value="MRN69364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="36" mass="4128" checksum="06709F15C8CB8849" modified="2020-06-17" version="1">MSSKTNVPYKCEECGMSFNSLEELQDHINEQHVAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB5</accession>
    <name>A0A6A8FJB5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">pyrH</name>
        <name evidence="8" type="ORF">FIO02_03245</name>
        <name evidence="9" type="ORF">FIO04_00340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="WJXE01000037">
        <property type="protein sequence ID" value="MRN40045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000008">
        <property type="protein sequence ID" value="MRN68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_A">
        <property type="entry name" value="PyrH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN40045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="249" mass="26998" checksum="EB3530CD220E42CB" modified="2020-06-17" version="1">MNNINLNKKRRIVIKLSGSIFNTANGKESITKYARMLLEISDKFQPVVVTGGGEIARHYINIARSLGSDEANLDIIGIEVSRLNAKLLLVTLGDQAFSQVPKNLEEVALAAASGKIVIAGGLHPGQSTNATSALIAETVKASKFLNATDVDGIYDSDPKTNRDAKLFKKITVKECMEILGNESSMAGTYELIDIVALKVIERSKIPTQVLRSNVNNIKHAINNNSKYHVGTEIVIDPTLTRAATVKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD4</accession>
    <name>A0A6A8FJD4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnp1</name>
        <name evidence="7" type="ORF">FIO04_04925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000262">
        <property type="protein sequence ID" value="MRN69026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="97" mass="10582" checksum="5D69E0AB9A2373B6" modified="2020-06-17" version="1">MKEVLKKTMITPKNILSHELIGLSATIITSPQPTILGLSGTIIFETKNMLTLRTSAGPKKISKISAEKMRVLLPSSACFIRGPSLIGRPEDRVARTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE4</accession>
    <name>A0A6A8FJE4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="7" type="ORF">FIO02_01885</name>
        <name evidence="8" type="ORF">FIO03_01450</name>
        <name evidence="9" type="ORF">FIO04_01355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
            <strain evidence="8">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000017">
        <property type="protein sequence ID" value="MRN39782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000027">
        <property type="protein sequence ID" value="MRN60708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000042">
        <property type="protein sequence ID" value="MRN68327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="6">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN39782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN60708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="148" mass="16631" checksum="9E1FCD2A6E65843A" modified="2020-06-17" version="1">MATRLRKSRRQRGTRYCGWGQIGQHRQSGSRGGVGAAGKHKHFWIRTVIEEPSHFGHDSFYLLNRNPVRKWLNVRDLDGILAQHGSVRDKDTKPTLDLTSLGYHKLLGGGKVSGGGVKVRIEKISHNAKQKIEEVGGEVLLYNEHNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE5</accession>
    <name>A0A6A8FJE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000267">
        <property type="protein sequence ID" value="MRN69036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="524"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="646" mass="73131" checksum="77AD38C80D27DB4D" modified="2020-06-17" version="1" fragment="single">MVHIKKLEVYGFKSFGFRNTVLNFEKGLVAITGPNGSGKSNILDAIMFAIGETSPKVLRVDKFQSLFHDSQNSSTRLIRASLNFDNSDRGIPVDSDSVTLTREMEGQTGESQYYLNKKKVTKSTLVELLDIVLATSNKLNIIQQGMITRISELNSEDRRKIIEDIIGLSYFDEKKNEALKQLDESDRRLDVAMARMDEIRKRIDGLEEERNDQLRYKHLESDLEKFKAVKVSNTVRTIRSDLKSKAELLNSNALRSKDLTMQIEKNNSELEKLDSEKLKLIQEADIATRTKMKIATSVSQLVYDSERKSAVIMETGQRLIQIERRIASVEIEKQNINQKIENLHLQIEEKKTHVDERYGRLSFLKSDLAAMNSQIDELSTSASRYAEIRGKLEGRHNKLYEVKNHLDVSIARLEEKMIIVTGRANSLDSENLELKTNIEKNNQLHNELCITLDSEKAKLDAAIGLRDNLKKMKDTLQTSLKTSKDLLSTADTFTIKYEVKASTAKNAMTEDIAIAELMNMSNEFGIEGLVHNLITWNKNYERAVLAAGSEWMKAFVVDSVQSMISIAEHAKKTNLPRLKVIPLEIVRNVKRSYIPDGDPNIVGSLADFVNSDYKELPDFLFGNTALVKNPTAAYLLAREGCRAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH2</accession>
    <name>A0A6A8FJH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000016">
        <property type="protein sequence ID" value="MRN68180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="156" mass="17068" checksum="0357FB13E1185CEF" modified="2020-06-17" version="1">MSEEKTKGRFHKILVGIDGSEASIDASRYAIAIAKKYNSQLIAIFVLHMHGIRSVSSTFITAPTYGIEGFEEEKRAAQEWLDRIRLEGHAEGIDLGTEIVEGSTSVEATIVDYAEREGIDLIVIGTRGRTGFKRLLLGSVALGVVTYSHCPVMVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJI2</accession>
    <name>A0A6A8FJI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000459">
        <property type="protein sequence ID" value="MRN69391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="273"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="344" mass="38779" checksum="93E1623193C1C688" modified="2020-06-17" version="1" fragment="single">LLDKALERVKWSLSKLVEKQKITQIEADRIFHRITPEVDLELSLRDTDLLIEAVPEDLGLKKKVYTDVDKFAEEKTVYASNTSTLPITEMAALTGRPERFIGLHFFNPPQLMRLVEIIPGRDTNQHTIDTALDFVMRVGKEPVLCRKDVAGFIVNRIFIPLVHEAAYCLERDGASMTQIDSAVKYKMGFPMGIFELADYTGLDVIFKATSEMYARDTRIVNPHPKIKELVDAQNLGQKTGKGFYEYSGSTYERVNLTPEEAAKYNPTSLVAVSANNAAWLISNNVCTKEDVDKALRLGMGLKTDLFGTVEMFGVGNVVEKLREMAAKYGSRYEPDVYLQSYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ7</accession>
    <name>A0A6A8FJJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CbtB-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000502">
        <property type="protein sequence ID" value="MRN69454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="76" mass="8228" checksum="52DF1BFF2CF34AE5" modified="2020-06-17" version="1" fragment="single">MSTISKQITKETTNVPKIAVGVLAGILVFGMFVVGYDQGQLAQAVLSPFGIHPNHAQLMLLHEFNHDLRHAAGFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJK0</accession>
    <name>A0A6A8FJK0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000295">
        <property type="protein sequence ID" value="MRN69096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="73"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="195" mass="22953" checksum="0DB0234611CCFA53" modified="2020-06-17" version="1">MYNLMDLQITLCLNPYTYVTLTLTELRYIDRPRSEWRWKGHEVHMVTEPLNIQDLLCESTSDAQWKEFPSGTSIGHVHLHVSNLVNAKRFYSEILGLNHTATYPGAYFFAADEYHHHVATNIWLGEDILPRASFSNLTGLDHFAIHLPNKREFERMSKYLDEFNLIAEEEQADLRGFSRSFYVHDSDKIRIQFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL1</accession>
    <name>A0A6A8FJL1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">trpB</name>
        <name evidence="15" type="ORF">FIO04_00800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="WJXC01000023">
        <property type="protein sequence ID" value="MRN68220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="54"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MRN68220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="415" mass="46114" checksum="BDD1F3D69C1EAEFF" modified="2020-06-17" version="1">MLSNYPVNARFGDYGGRYVPETLVPAIEELERAYDRYKNDTDFRKELRYYLEQYAGRPTPLYFAKNLTEYVGGARIYLKREDLLHGGAHKINNTLGQGLLAKRIGKKRVIAETGAGQHGVATAIAAAVLRLNAEIYMGSKDMKRQRPNLIRMQLLGAAIHPVQSGSRTLKDAINEALRDWITNVQNTYYLIGSAVGPHPYPVIVRDFQSVIGQEIKMQMEQLSNRREHPDAVVACVGGGSNAIGTFYPFVDDSDVSLYGVEAAGKGIKSGKHSATLAAGSHGIIHGMFTYLLQDQFGQVSDTHSISAGLDYPGVGPEHALLKDIKRVNYVNCIDDDAAEAFLLLSRLEGIIPALEPSHAISYAMELAKNMNRNENIVVTLSGRGDKDVDVVQRYLKMKEKKNEKKRNNEKNKFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJL8</accession>
    <name>A0A6A8FJL8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="10">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ctaB</name>
        <name evidence="11" type="ORF">FIO04_00850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cell membrane</location>
            <topology evidence="3 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="10"/>
    <dbReference type="EMBL" id="WJXC01000025">
        <property type="protein sequence ID" value="MRN68230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="291" mass="32178" checksum="71AF220E77FC2326" modified="2020-06-17" version="1">MSAGNRLKNYYELTKPKIWYLLVFTAFAGALTASFLSHILIPPVTWVLIIGGVAAGSASADTLTGYNDRDIDAIMDRTKQRPIPSGRISPHNALAFGLILAAISLVLAWLINIWAFALMGFGLFDNIIVYSKWLKRTSRTNIILGGFSGGVPAMIGYVSVTTQNIEIGLIMAGLVFLWIPTHIWSLALHFREDYRKAGVPMLPVVSGEKKSVRIIAGTTLMMVLFSILPFFINHFGMIYLVTASISGVIMLALSIWLLLKPSERVSWIVFKVTSPYLATLFIAFIMDSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN9</accession>
    <name>A0A6A8FJN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000062">
        <property type="protein sequence ID" value="MRN68427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041017">
        <property type="entry name" value="Thioredoxin_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17991">
        <property type="entry name" value="Thioredoxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="71"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="402" mass="44374" checksum="0D83AEECA07A5BDD" modified="2020-06-17" version="1">MNRDNVSAVAMAIAVIAIIVGFGIYFNSPSLNKASSSSQQQLEKVVSAATTTNGTIKTIKLDKAQFLQIDKSQFQKAPEFAQIAGYINTPSNAPLTLASLKGKVVLVDFWTYSCINCIRTLPHLNDWYQRYADKGFVIVGVHSPEFEFEKNYDNVKAAVQKLGIKFPVILDSNHGTWNAYGNMYWPRDYLVDTQGYIRHDHIGEGDYNTTESAIQSLLAEGAALNGMKDISFNTAKSTTTINRSSLAYVDLTKQITPEIYLGYSFARAPLGNPQNFQPDQTIPYSIPPNTSFNPDIVYLDGLWKNNPDNMELQSNTGHIVLTYNARAVNIVAGGHGQQGIVTEDGATKILNNSLGKDLTQDGKFVLDGQRLYNLALYNNYGSHSIIINVSGKGFQLYTFTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU6</accession>
    <name>A0A6A8FJU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000288">
        <property type="protein sequence ID" value="MRN69082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="360" mass="41320" checksum="7E3645E2FA80059B" modified="2020-06-17" version="1">MTPIINWLTLPTDWHPAQIEIQYANEDIAKLPLEIISNINERFDCCIDQNGVALLMENEKLWNAIKVLKDKGIRVRFVTALNEGNMSFCRQMMRCGEVFHNDKIKGNFQIADGISYLCYIIENEGKITERQQLFHTNTKSFVDIQQYLFDNLCNNATPAKEKIKEIGRGTRSEFADTINEPAEIRKIVTNLLMSARDEILLLFSTANSFYRAKYGGMLNLLSQVPKDVSVKVLIQAGDDVAKDIIQEELRQSHGQLHVQYITKPLQTKIVTLVVDQATSVAIEVNDDAKKTFEEASGSAIYSNSELTVSSCISIFETLWIRSEFDKQNKIKQAYFQMFKGLELKDEFYSRRWSSEQQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJU7</accession>
    <name>A0A6A8FJU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoacid:acceptor oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_05735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000339">
        <property type="protein sequence ID" value="MRN69186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="128"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="410"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="523" mass="57608" checksum="11B13CD4E59E2BC9" modified="2020-06-17" version="1" fragment="single">PITVNGMVNFAKNNGAVLYDIPYFGILKQFSVAINEPALSKLTRMINVMALSASMAILDFDKEILAKAIKVIFKAKPKIADGNVLAANYAYEYVKSRFDLSQSQLKLSSKPQSADIILVQGNQSSAMGKLVAGCRFQTYYPITPASDDSEFLESNQIVEQTDGNKGSMVVVQTEDEIAAITMAIGGALTGVRSGTATSGPGFSLMAEALGWAGMNEVPLVVSLYQRAGPSTGLPTRHEQADLRFAIHAGHGEFPRIVFASGDIEESFYDSVKAFNFAERYQMPVIHMLDKLIANSVMTCKYFDQSRVAIDRGKLLQSLPPSVEVGAAGHYLRFKFEESPVSSRIPLGTENGIFWNSGDEHTEEGHITEDPFIRNKMMDKRLSKLDLALEEISDEDKAVSYGQLDPSLALTVIGWGSTKGAILDALDELALEGKRVHFVQVRLMNPFPTALLERMLFNTKILVDIEMNHTSQLGSLVKQYLHRDSEYRIVKYNGRPMSTSEIYNALMSIINGNAPRRIVLEHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV6</accession>
    <name>A0A6A8FJV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00300 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000080">
        <property type="protein sequence ID" value="MRN68497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12144">
        <property type="entry name" value="SDH_N_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005239">
        <property type="entry name" value="CHP00300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007545">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043009">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04455">
        <property type="entry name" value="Saccharop_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00300">
        <property type="entry name" value="TIGR00300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharop_dh_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="424" mass="46972" checksum="DD26B06BA63DE8CD" modified="2020-06-17" version="1">MTEKKYEQEIEVKGHLIDSMILTRIFDNIMDLKGDFQVLDFNVGKKKKDVSYARLIVRGKSREHLNELLESLYREGAQPISIQQVMLKPVLKDMVMPDNFYSTTNNTTQVYYKGVWIDVVNMMMDKCIAVETEKKTAECKMIRDLKKGNMVVVGEQGVRIIPQERPREGVDLFQFMGSSSSSERPTQQIARKIAVDIYNTKETRGGRIIVVAGPVLVHSGASEALAKLIRMGYVHGLLTGNALAVHDVENALMGTSLGMNIKDGTLAIRGHRNHMQAINEVFKVGSLKAMVRKGILKSGVMYECIANDIPFVLAGSVRDDGPIPDVITDIVEAQRKYKQVLEGAKMVLMFSTMLHSIAVGNMLPSSVKVVAVDISQPVVTKLIDRGTIQAIGIVTDVGAFLPTVVKHLEDIEQSITDEKKGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJX2</accession>
    <name>A0A6A8FJX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000085">
        <property type="protein sequence ID" value="MRN68517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="48" mass="5363" checksum="74ADFF96C46C8114" modified="2020-06-17" version="1">MVIDPVCKLEIDEKASQSKSKAGGKDVYFCCPHCKAIFDKQPSKYQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC4</accession>
    <name>A0A6A8FKC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uvrA</name>
        <name evidence="8" type="ORF">FIO04_02995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000124">
        <property type="protein sequence ID" value="MRN68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="173"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="522" mass="57426" checksum="9AFD2A9F10C52F4B" modified="2020-06-17" version="1" fragment="single">CDLSIDECFNFFDKITLSETERHIAKIILKEIISRLDFLRNVGLTYLTLNRMTASLSGGESQRIRLATQIGSNLTGVLYVLDEPTIGLHQRDNARLIDTLKKLRDLDNTLLVVEHDEEVTRCSDWIVDIGPGAGVHGGQIVASGTLGKILDTKDSVTGAYLRGDMLVSHPAQNRRTPLNWVAVHGARENNLKSIDAQFPLGCMTVVTGVSGSGKSTLVNDIFFRALANYFYDSKERPGKYDSISGLEHVDKVIGIDQSPIGRTPRSNAATYVNAFTPVRELFSKTPHARELGYKPGRFSFNVSEGRCEVCEGGGVRRIEMQFLPDVYVTCDECKGKRYNSETLKVKYKGKTISEVLDMTVEEALEFFKNVPVVEKKLQTLNKVGLGYIRLGQPATTLSGGEAQRIKLAAELSKRDTGKTVYILDEPTTGLHFADVSKLLSVLNTLVNLGNTVIVIEHNLDVIACADWIIDLGPEGGDGGGEIIVAGTPEDVAKKEDSYTGRYLKPKLSIDQMIIRKGARTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC7</accession>
    <name>A0A6A8FKC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000394">
        <property type="protein sequence ID" value="MRN69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="408" mass="45596" checksum="1259688126EAAEED" modified="2020-06-17" version="1">MPVRENSTNSANESKGSYRHLYVVVEHDDSNLIPVTLEMLGEARRLMDIFNARYSSTEKVVAVVLGVNIKKLCEELVYYGADAVICVENPNLRYPINLIDTKVISQVARDKVCASKVSPEYSEEFKKPRYMFFSADNVGRHLSSTVLAELESGLASDINKLVIEDLEIKHEHKTKGQLARYEKTLEMYRPDFSGFLWTTILCLDNRNPAIQREYHPQACSIIPGVFAPLQRDPARTGIIVDFSPELDQADKSVKVLNRQVTKSPVDFDSHKAVISFGRGIKDSPEDNIKLIVELANELNAEIGVSLPISKRPYSVREPVSSLYMNSDRVIGTSGRKVAPAVYVAIGVSGAMQHIAGMKESGFVIAINADANSPIKDECDIFIRGRMEDVLPVLIEELKKQKQVMEVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKD2</accession>
    <name>A0A6A8FKD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine--fructose-6-phosphate transaminase (Isomerizing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000443">
        <property type="protein sequence ID" value="MRN69366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="178" mass="19608" checksum="49CC56D4D49BBAA6" modified="2020-06-17" version="1" fragment="single">MCSIIGYTGRLNVAPVLVESLKRMEYRGYDSVGIATIDNGRISTRKGIGRVADVDKALNLIMMPGQIGIGHTRWATHGGVTDKNAHPHYGCTADIAVVHNGIVENYKELKEELIHLGHKFKSDTDSEVIAHLLERYYAEQKDGTQTIIKTCKRLKGSYAFVAASEDGTICGSRYDEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKD8</accession>
    <name>A0A6A8FKD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO03_00980</name>
        <name evidence="4" type="ORF">FIO04_06170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000016">
        <property type="protein sequence ID" value="MRN60616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000383">
        <property type="protein sequence ID" value="MRN69272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="372" mass="41204" checksum="2D0A2FC7DC17BF78" modified="2020-06-17" version="1">MGAEFYGESYKGNDEPIFGGIPTFLKLPWLRSHEELKKVRPDVAIIGEPFDFGTTIRPGARYGPRAIRAASTVPSPPYEHFNIETGMDPFGVFKTADYGDVVVSPGDVVESLKRMTDKVKEVLDIDGLPVMLGGDHSVTFANVRAFAKKYKNIGMIHIDTHADCAPQGLCGFKYDHGAHIRRIMELGCLKGKNYTLIGPHGYWPGPDLYKWMADQDFQWFTMLDVEELGIDQIAKEAADRANDNVDAVYISWDIDTFDPAYAPGTGEPEPNGLTSREGMRLMRLLSTSFDPDKFAFDLVEVAPNYDVSDQNSYNGGITSGLANRLITELLAGLALTKKGETGGNPVRPKLYRGTGHTYDFGKPRAKAPKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKH5</accession>
    <name>A0A6A8FKH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000135">
        <property type="protein sequence ID" value="MRN68687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="338" mass="37800" checksum="80B558B89ED7B190" modified="2020-06-17" version="1" fragment="single">SKSLCYDYLVIAVGSETRFFGMSDVQKNAFTIKTLDDAIRLRNHIIYLLEQADQLLPESSYDNNKSVQSQKELLTFVIVGGGFAGVETAGELNDFIRDSVNDYYHNIDTRNIKFVIIQSGNRLLPEMSEKLGQFALENLRKSGVEVILNSRVIGATENSVKLRDGIIIPTKTIIWSGGVAPASLVSNLLCTHDSKSGRIIVDKYLEVPNYKGVFSIGDCAFVVDPSTGNPYPPTAQHAIREGTAVAKNIIAEIEGKPDKKEVFDYKTKGMMASIGKRTGVGNLLGIQVQGFLAWWIWRNYYLAHLPTLHKKIRVLADWITDIFFRRDVTMFKTLAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKI8</accession>
    <name>A0A6A8FKI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Succinate dehydrogenase/fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FIO04_02555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000097">
        <property type="protein sequence ID" value="MRN68560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="8"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="447"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="570" mass="63463" checksum="D6C7CC281DE51F42" modified="2020-06-17" version="1">MVDSISQDVLIIGSGLAGLRAAISSAATNEKLEIAVVSKVQVMRSHSVSAEGGTAAVLFEEEGDNRESHIYDTIKGSDFLADQDVAQRLVHDTPYEIYQLDHWGMPWSRRNDGRIDQRNFGGYSFPRATYAQDKVGFYEMQTLYDTSLRYDNIRFYNEWFCTSILSDENSFRGVTAIEMKTGNFFKLLAPAGIICTGGAGRIYSFSTYAYSSTPDGLDMAYRAGIGLKDMEFVQFHPTGILPSGILITEGARGEGGYLINSGGERFMKKYAPEKLELASRDIVSRAMIREIQQGRGFKHESGADCLKLDLTHLGADRIKERLAGIRDIGIKFSGVDVIDDPIEITPVCHYMMGGIHTNIEGASEMRGLWAAGEAACNSVHGANRLGANSTSECLVWGRITGENAARYASSSKAASVSVSPQQVLEEEKRIYDGIFRGSGEVNPYQLRRDLTDIMDAKAHVFRDEEGLQEGLRKVMALKSSSWKHVDDKAKEYNTNFINVMEIDSMLRIAEIVLMGALSRQESRGAHARTDYPRRDDVNFLKHTLAYYGMQPKIAWHPVTITRYAPTERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKL5</accession>
    <name>A0A6A8FKL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000276">
        <property type="protein sequence ID" value="MRN69053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="137" mass="15923" checksum="CDCB62E29D2139A7" modified="2020-06-17" version="1">MIDYEHLYAFTKEVLKLDKSIRWVGIASKYGVLLNTEHREGLHPLMTDEENEEYAHLTVTRHKTRIKFEPKTGPLVYALGKYEKLNRATLHINEDYYLLIALDVEEKNFDNIITEKVIPLIKKEKGNFTTTDKTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKQ4</accession>
    <name>A0A6A8FKQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_05655</name>
        <name evidence="2" type="ORF">FIO03_03725</name>
        <name evidence="3" type="ORF">FIO04_02910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000088">
        <property type="protein sequence ID" value="MRN40512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000103">
        <property type="protein sequence ID" value="MRN61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000119">
        <property type="protein sequence ID" value="MRN68630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="193" mass="21126" checksum="546675B94B12DBE6" modified="2020-06-17" version="1">MMKEPAITTVLIIVISASIPISSTILMHSNAKAQPQQQDQQPIVIRIQNTSMSEPAPNAPLNNQTLPHQIVVALPIRQDGKIWTGTVTFTASKPIEVEVEHKYNRYNITLDAKHGEPYHAKWFDGTNIALSTMTMFTNTPVAVTNTPISTGSFTFTGSALVFHKTDGVPFTVTYTLDVVANPLTAPSFLSHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKR2</accession>
    <name>A0A6A8FKR2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (cytosine-N(4)-specific)</fullName>
            <ecNumber evidence="3">2.1.1.113</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_05345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000301">
        <property type="protein sequence ID" value="MRN69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="72" mass="8079" checksum="C33EEDAC30A9504A" modified="2020-06-17" version="1" fragment="single">MQVEQNVVNVIIGGNCKEVLKRISPNSVQLTITSPPYRNAIDYEMHASGNGGYYRGRSNIETSDYLDEMVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKS0</accession>
    <name>A0A6A8FKS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000309">
        <property type="protein sequence ID" value="MRN69123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="97" mass="10972" checksum="BAE0E4ED1BB6C5EB" modified="2020-06-17" version="1">MNISRPDYISEAKRCLATNSYVLVAETTTKSLSPGGRLSRLRDVIKENGFEYITMSKEETITGTWNVQILVYSIPTRFLHIYECVINLGNLTANLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKT7</accession>
    <name>A0A6A8FKT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000169">
        <property type="protein sequence ID" value="MRN68787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="460" mass="51742" checksum="81B22F3E8C5EF00A" modified="2020-06-17" version="1" fragment="single">MTTELRVHPSFFREFATKTWVSPNEIVKELIENAFDEDATISVVTIMKDGSVVIEDNAGMDQDSMEKFLLLGSPHKKHDRISPRLNRVRTGRYGTGRLSFLTSFESMKIRTKRHKFEKTIVIDGNTLDKLFSGNALLDELHESSLGRNGTELTLKGSKTVIDAFRLIKEIRKLAILRQPLFEVYIKEADKFVEWDRSGAQQIIAPDIQGHRIMLNLEDGRITGELVIARRPLTEDEKGIAIMVGNHIVTRGNFGFDTKLSKVTGFVRCDTLTSRFADKSAIIEDEEYAKFNQAMRAFIIETVLPSLTEYEDVLITREESKIYREIDKVLGQAIVENLETQQEVDGYEIIDVNEKAPIEEGESSAALFANISSDENTSFIVSKEAQPHGGIKIESPPVSETTITQPRQIQQPTPYVGSLSATDKTNLDLLQPEQVVAVTTPVNTVITKQIKKPILKRTFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKZ4</accession>
    <name>A0A6A8FKZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000340">
        <property type="protein sequence ID" value="MRN69189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="142" mass="16645" checksum="48E7F1A8A25EF2E7" modified="2020-06-17" version="1">MEELDFLHEVCLTALFSNRVVKFAAVLDNNGKLLVGEYRKGFQSSWQADFISDNNYHHDPSYLFYLDYLVPAIKKRRICCAGYTEEQQRQQQEIHFEITEIDDNVRLAMAPLTERNDKYLCIFLESSAPYQEILSKLRNAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL01</accession>
    <name>A0A6A8FL01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000345">
        <property type="protein sequence ID" value="MRN69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="101" mass="11188" checksum="761512CD6B1C5BC3" modified="2020-06-17" version="1" fragment="single">MAKIFVLVPLVFILIFGTTILPNSIAQTQISCGIQIGGLIHTQSDQQQYCIGSADGQKAANSSFQHHTNFNDFPPQAQDLNHTAAYNEGYKNSYNDEWNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL08</accession>
    <name>A0A6A8FL08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000192">
        <property type="protein sequence ID" value="MRN68857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="77" mass="8542" checksum="36905D3AFB1B7EFA" modified="2020-06-17" version="1">MNHKAYAIAPIVAVVAALAFAAVMFVIPQQAFAWGHHHHHNHNNGNRIDVSQTINQENDCSFAECVNDAQNQADIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL18</accession>
    <name>A0A6A8FL18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_04115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000196">
        <property type="protein sequence ID" value="MRN68867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="332" mass="37401" checksum="BAD9B01264AEA4CA" modified="2020-06-17" version="1">MGHRKYSAPRRGSIAFRPRARAKSIESRIRSWPQSAEEKSKLAGFAGFKAGVIHVLTIDDREKTPNFGKHFLNPSTVVVTPPVRIIGIRAYSENQNGKHVIFDVYSKDLPKDLRRKFTANFDEEKLVNSESKLDRAVSIVALVSVLPRDANLSQKKPFVFEIAVTGKDVKSRYDYLKTILGKEIRVSDIFQVGQYIDVSAITRGKGIEGPITRFGVKRKQHKSRKSVRAVGTLGPISPAVVMYTVPRQGQRGFHQRTEYNKRILMISNTEKNAADHINPSGGFKHFGLVNGDYIVVKGSIPGVPKRLIKMRQPIRNFQKKIFEPKVLEVVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL31</accession>
    <name>A0A6A8FL31_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arg_tRNA_synt_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_07420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000540">
        <property type="protein sequence ID" value="MRN69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="6">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="54" mass="5985" checksum="E742E7075F14332D" modified="2020-06-17" version="1" fragment="single">MTFRALLDEIRQVVSAGLTDLGYPQESFDLSEPPRPEFGDVSSNVAFQIGKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL52</accession>
    <name>A0A6A8FL52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent sacrificial sulfur transferase LarE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">larE</name>
        <name evidence="2" type="ORF">FIO04_03630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000164">
        <property type="protein sequence ID" value="MRN68770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAD_synthase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="271" mass="30395" checksum="E251B4A73BEB4067" modified="2020-06-17" version="1">MSQETDRFPELIRWFSRNGTRVIVALSGGVDSAVVALAAKKAFGDNSIAITANYKTLSQEELSSAYVVAEEIGIQHKLIQYDEVANSDFAKNDQLRCYHCRKELGMRLLQEASKLNANLIVDGTHFDDIGNNRPGIRALEECNVRSPMLELSISKAQIRAIARKFKLSIHDKPSNSCLASRIPQGTTVTYEKLARIEKSETIVKELFNLRQVRVRDHGDIARIEVQKEEIILLFDVGKLENLDTLLKELGFKYVSIDAKGYRTGSLVLTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL59</accession>
    <name>A0A6A8FL59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000378">
        <property type="protein sequence ID" value="MRN69263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="51" mass="5842" checksum="CA9944E2B43B5118" modified="2020-06-17" version="1">MQTSTGRPKRAGCRKTRTDNDRISGQTEGKGIIQDYVNRRYNQFVVDPKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL70</accession>
    <name>A0A6A8FL70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000216">
        <property type="protein sequence ID" value="MRN68917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="116" mass="12927" checksum="C7E2612005F178F2" modified="2020-06-17" version="1">MDPSSGLANNFDFMVSRIRNSFSISTIGVRSGTLGSADISAHLSYDLDTFKVIDKFKFTQPSIDEKMVVILANRISVNNRTIDDYGNGCNAAIFGKPDLYFKDSLRDYYNGRASEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL96</accession>
    <name>A0A6A8FL96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000229">
        <property type="protein sequence ID" value="MRN68947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="92" mass="10203" checksum="D1DFA397AAD14909" modified="2020-06-17" version="1" fragment="single">MSNYRLPIRIEILSSAENVSSLDNDLHKILVDASDSCEYTAFVDKDGVTQIKIQCTITEEEKQYAWTQLRLKHATDCSLSAEPSGVPANAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLJ0</accession>
    <name>A0A6A8FLJ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000273">
        <property type="protein sequence ID" value="MRN69047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="167" mass="19234" checksum="53AB1FF99C371986" modified="2020-06-17" version="1" fragment="single">DDTKDSSYYAAGLTTYSNSKSIISSYASIFESLWKQNELYEQLKIHDKMQHEFINVAAHELRTPIQPIIGLTEMLRSQIKDIKQLELLEVTIRNAKRLMQLTNDILDVTKIEGKSLDLKKQEFNLNDVVINSMNDITLGRDFLKNENISLSYKPQDILIQADKGRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLP7</accession>
    <name>A0A6A8FLP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_07115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000501">
        <property type="protein sequence ID" value="MRN69453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:peptide alpha-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="PTHR23091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="165" mass="19079" checksum="715FD29A716906DD" modified="2020-06-17" version="1">MQTALRRVGSYMIRRCEAKDLPTVVDINMLTLPEHYSDYFFESILRELPESFIVAELYDKVVGYIMCKIEFGFSNFRKLGFVKKGHVVSVAVLNEHRNQGLGKALMLEGINGVIARKTDEIYLEVRVSNESAVRMYERLGFQIKSRLRAYYRDGEDAYLMALEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLT3</accession>
    <name>A0A6A8FLT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000324">
        <property type="protein sequence ID" value="MRN69157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="463" mass="53456" checksum="986C28259C6224EC" modified="2020-06-17" version="1">MKRATSMDYPTGPTQKLPLVQFLNFLRDPIGVLVDISRYGDISHFKFGNQHIYFLNHPDYIRDVLVTYDTRFIKSRGLQLAKKVLGEGLLTSEGTTHRNQRQLIHPAFNQDRLTTYATTMTEYILRISNRWKDDDTLDVHKEFMQLTLAIVCKALFGFDIESEAEEIGDHVTTLVEYFNRARMPLGELIEKLPLPSNRRFHYAKKQLDTLIYRIIHEHQSTRITHVKDLPRHNHHGDLVSILLANKNITSDNGNYVISKLQLRDNVMTIFLAGHETVANALTWTFYLLSQNNREEEKLYEEIDSILGNDRLPTAADIPKLEFTGKVLSESMRLYPPAWAIGRQAIQDCKIGGYTIPAGSTILMSQYLMHRDKRFFPEPGRFNPERWNSETRTNLPRFSYFPFGGGPRACIGEPFALTEGILAIAIIVRRWKMKLESGHPIALQPLVTLRPKYGMRMRLIRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM03</accession>
    <name>A0A6A8FM03_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malic_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000284">
        <property type="protein sequence ID" value="MRN69070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic_M" evidence="2">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="261" mass="28435" checksum="B7C2D1E8645D3B80" modified="2020-06-17" version="1" fragment="single">SIPLFHDDQHVTAVITLAALINSLRLVEKRFDTVKVVISGAGSAGYGIFKILQDAGCKDIVVTDSKGAIYEGREDLQNTDPNNSYKQEIASNTNPRKLVGNLHEVVREADVFIGVSGKSGLLSKDMVRSMHSNAIVFALTNPDPEILPSDALKAGARIVCTGRSDFPNQVNNAVVFPSVLRALLDTRAKGLDEQMLVTASYAIASLVEETHLKEDYVIPKVNDPRILPIVTETLKKAIRSHSPKGDAENKDRHDLRDAISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM10</accession>
    <name>A0A6A8FM10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000364">
        <property type="protein sequence ID" value="MRN69237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="91"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="370" mass="40328" checksum="2CE41D0B9F3E1F94" modified="2020-06-17" version="1">MTLSLGLLLIGILGLSCLAATISKEQQSALAQPFIQTIKYRNLVIDLGNGLKTNAQLTLPAVGKGPFPGVLLIHGSGPTDKNETLGFVHKNGPKPPTPFWQIAQYLSERGFAVLRYDKRGVGANSTIINSNVWGNATINDLIQDSKKALNVLIQQPEVDPKRISIIGHSEGTIIAPRVAIDNSTKVKNIILMGTVALSTRENTHNLDVTLPSEYATQVLDKNHTGLISIQQIAKDPVLKNYFVPPSVLLTNNIKVITNALVKEFGTNDSISIEKQLNPLLIKGYENLTAFNLLKCNNFEPCPVWLRSAFSLIPTLSIIGNVSKSTGILILNGDNDSLTPVQQAFLLQQRLTEVNHPDHTLITYPNLGHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM13</accession>
    <name>A0A6A8FM13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000287">
        <property type="protein sequence ID" value="MRN69080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="290" mass="33369" checksum="4AB29F7F9D481E85" modified="2020-06-17" version="1">MSINNLQPLIEDWKANVVNSLGDGNDTERLAEYALHVSRILAYPDLDVKDILDKIDAMGRELILATKKLMPLRPTQIIEKINNYLFKQKEFRANLQDYYNPLNSYVNVVLEQKSGIPITLSIIYIRIAHILKFRLHAVNFPAHFLIKHILEGDGSEIIIDPFNGGRIMDDYTMKELLDQFYPGQNIALTRAFVEKATSAQVMIRMLNNLKGSYYESQDIERAEIANEMIIAIEPHNPDAVRDKGMIFLKRNNPLKALEMLNMYLELDPEAEDADAVLDIIRQVREQINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM48</accession>
    <name>A0A6A8FM48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000307">
        <property type="protein sequence ID" value="MRN69120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="498" mass="54498" checksum="D759EE51E1D5E036" modified="2020-06-17" version="1" fragment="single">TTTTTTTTTTTPIKHLVVILQENVAFDHYFGTYPNATNPLNEPKFVANPHTPSINGLNSAGLLTNNNTNSAHPFRLDRSQVITCDNNHAYAAEQKAYDGGLLDKFVQYAGPKYGHCDPNQVMGYFDGNTVTALWNYAQHFAISDNFYGSTFGPSTPGHINLISGQAIRALPANTKIPPSLKFDGVVNGTLIGDIDPKFDDCSRNSKLYNVTVAMQGKNIGDLMNAKGVTWGWFSSGFRLLSKTGNATLDCNSRQSHTSTSEIPNKDYYPDVEPFQYYNSNANPHHLPPTSVEMVGHTDQANHQYDLTHFWNASEGGNMPSVSFIKAPTYQDGHPEISDPLEEQTFLVNTVNRLESLPEWNSTAVIISWDDSDGWYDHVMPPIVSQSGDPVNDALLGRQGLCGHAPTGAAQDRCGYGPRIPLLVISPYAKVNFVDHSITDLSSILRFIEDNWGLGRIGNQSFDVKAGLINNMFHLSTTGHAGKLFLDPTIGIQNSTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMA7</accession>
    <name>A0A6A8FMA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000430">
        <property type="protein sequence ID" value="MRN69347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="106" mass="12094" checksum="8CA59C7E36242F5C" modified="2020-06-17" version="1" fragment="single">PSAVTEDTVIDFVNRMRLPNAKYAFMSTLLGIRDSPNLSDRLPKLLVPTLLIWGDNDNMIPMQYLEDYRQVPQGEIVILKDCGHTPYVEKPAEFNKALLNFLVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FN23</accession>
    <name>A0A6A8FN23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000481">
        <property type="protein sequence ID" value="MRN69420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="122" mass="13868" checksum="96BCD8FE9B7FBDFD" modified="2020-06-17" version="1" fragment="single">MRTRFGENTFGNCVTLTIDGQETFTLMYEKIFKAKTSILIANYELDPRLRFIRGDSQSSSLINNNLARSSSGSTSEPENIKLSHQNYTASPLQDLLFEKTKQGVEVKIIVWQPKLIIRLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFK7</accession>
    <name>A0A6A8FFK7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Copper-bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="1">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6283" checksum="7C3AB89A9C65F4C2" modified="2020-06-17" version="1">MIGSEKYVNSRWLIPKGQQFLPGSSTTFTVTFLKAGTYNYFCEVHPWMHGSVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG31</accession>
    <name>A0A6A8FG31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000048">
        <property type="protein sequence ID" value="MRN68355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="61" mass="7278" checksum="360EA088F183C14C" modified="2020-06-17" version="1">MEAKYHREIEETYREINHPSGVSEVYEPKKRELVEKVQQGSQRDDKESCSINKRKITRNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG58</accession>
    <name>A0A6A8FG58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_01655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000053">
        <property type="protein sequence ID" value="MRN68385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="25328" checksum="998BEADD5C782EB6" modified="2020-06-17" version="1">MSGNINKILARLGEQSKRERSGEIKVLPEDEMLAITPDTGMFFKILLSAMHARRILEIGTSVGYSTLWFAEAMIQDATTGPEGAEKHIITVDMNHSKIERATKNFDEARVSGLIEVLEGNARNILHELLKNFDGKNHIKKTDGLFDFVFFDADKEYLREYFDLVLPMLRTGGIVATDNMLYPEDYRPLMAKYANYVRSKPSLLSVTVPIGNGEEITIKLASEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGJ5</accession>
    <name>A0A6A8FGJ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="14">BCAT</shortName>
            <ecNumber evidence="14">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ilvE</name>
        <name evidence="15" type="ORF">FIO04_01535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 14">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 14">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="14"/>
    <dbReference type="EMBL" id="WJXC01000049">
        <property type="protein sequence ID" value="MRN68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 15" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MRN68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="25229" checksum="FA11CB151A10A5E2" modified="2020-06-17" version="1" fragment="single">MKTKGADFIWFDGKIVKWEEATVPVTTHALHYGTSVFEGIRAYSSKNNLHVFRLREHMDRLRHSAAVYSIAMNYSAKELEEATIELLKKNRMKESCYIRPLAFVGQHGIDLNVTRDSPTHVVLIVFPFAKYFKVEGISACISSWRRIHDSSTPPMAKAAGNYLNSVLATQESNRNGYDESVMLDIDGNVSEASGENIFMVRSNKIYTPYIAGSALEGITRDTAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGL8</accession>
    <name>A0A6A8FGL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000101">
        <property type="protein sequence ID" value="MRN68575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="107" mass="12122" checksum="E1B27C5D607DC208" modified="2020-06-17" version="1">MNMDPRVRFVGVLAKDAKLIEGGMRKEVSPLLPADKDDLFYLRIISHLKELKDLASTLGDLGYGFIKMAKISFVYLSLKDSRTLLVSMEPDVDPSFIIPTIRNYMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH26</accession>
    <name>A0A6A8FH26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000004">
        <property type="protein sequence ID" value="MRN68102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="351"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="469" mass="50834" checksum="64D2B7BED6EA41C7" modified="2020-06-17" version="1">MKSARELSTNKKKRIVIIGGVAAGTSAASKAKRIDPNADVKIIQEESVVSYAACGIPYVIEGVINNFEELIERPPDVFKSKYDIDVIVNTRAHKIDSFRKQVHATDLQSGKDTIFDYDFLVVATGARAVVPNIKGVNQKGVFFIRNYSDGVKINDSTRTRDVHSSIIAGAGLIGLEMVEAFKKRGHTGRGDMDVTVVEMADHILPSLLDKNMAKIVERELEANGVKIILGERVEEILGRDGQIKGIRTSAKRDIDSDFIVLGTGVRPNSEIARDAGVELGYANAIKVDEYMRTNIPDIFAAGDCATARNYITNKDTYVPLGTTANKQGRVAGENVAGGNTRFRGIAGSAITKVFDLFIGKTGLTSEEGIRNGFDPVEEVIESITRAGYYPGNKPIWIKIVADRKSGRVLGSQIVGGEGVKERIDLIALALLLKADIRDLASYDACYVPPASPVWEPINIAASQTAKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH71</accession>
    <name>A0A6A8FH71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000101">
        <property type="protein sequence ID" value="MRN68574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="507" mass="56570" checksum="699688150C53E734" modified="2020-06-17" version="1">MTFSLADELRRIAKGEILSDSWSREIYSVDASHYTIKPSMIACPSDESDVEEICQYCFSKSLPITARGAGTGLLGQALSNSIIIDFTRHMNKILEVGTDYVVVQPGLVKGILDKELKKKGKFFPPDPASSNYCTVGGMIANNSSGAHCLAYGSTIDLLQELRVVYSDGISRLINSNSSDGEEKDRRITDLLRLLSAHRDIIQKGYPRVTKNSCGYRLDKVINDKAFFPHKIFAASEGTLGIVTSARLKIIDIPLYRHLIVLGFEDLLSAISVVPFILKFSPVALEILDNTVVRYNVSNNSNNINQQLQNEEAGCLLFIEFAGDKLAEVEQRLDSCSDKLSDKCIIIESAADEQSLIRMWGARKNALNRAMKLTVGSRKPIGLIEDTVVHPDMLYDHAQQLLQMYSENKLDYVIYGHAGDGNLHTRPLIDIHSQAETQLIDRLANKVFERVIRAGGTITGEHGDGLARVKYIESVYGPEIYCLFREVKRLFDPRCIMNPGKKVIQYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH74</accession>
    <name>A0A6A8FH74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_01245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000038">
        <property type="protein sequence ID" value="MRN68306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="325" mass="36675" checksum="F42B850D4FB2E94A" modified="2020-06-17" version="1">MDCLIAIRDLVKRYDNLTAVDRLNLDIHENEVFGLLGSNGAGKTTTIHMLATLLKPTSGTATVNGFDIVTQSAKVRGSVGIVFQAPSSDDMLTGYENLKLHSWLYSVPRQVREKRIAEVLDLVGLTERKSDQVKKYSGGMRRRLEIARGLIHKPKVIFLDEPTLGLDPSSRESMWKYIERLVKEEKITIILTTHYMEEADMLCDRIGIIDRGKIIALDTPSKLKGMMGGDIVKLKLVEKKRPNTDMLKNFSFVHKIENISDDGLLVLSVDNASRNLPIILKYIDAESVEYTIPTLNDVFLRSTGRNIKEEAEGGFMEKYARYDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHB3</accession>
    <name>A0A6A8FHB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="6">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_02830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000114">
        <property type="protein sequence ID" value="MRN68614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011830">
        <property type="entry name" value="LEU1_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02090">
        <property type="entry name" value="LEU1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="504" mass="54973" checksum="6BE20436008BD8CF" modified="2020-06-17" version="1">MLGADSKVRIFDTTLRDGEQTPGVSITPEQKVQIAIKLDELGIDAIEVGFPVVSHGETIAIKNITKQGLKAEICGLARAIKSDLDAAINCDLTYVHTFIATSDIHMQFKLKMDRQQVLEKAVWAVEYAKKHGVEVEFSAEDATRSDRAFLNQVFMAVANVGVDRLDIPDTVGYATPQYIEQLVKDVKAYTRLPISMHCHDDFGLAVANSLSGINAGADCAHVTINGLGERAGNASLEEFVMALQCLYGRKHNVKTELLYETSRFVSNTMGIIVQPNKAIIGENAFGHESGIHTHGIINNPLTYEPISPDLVGRKRWMQAGKHAGAHGIKAMLEGFGIGPTEKELYEIVEKQKNLADKGKSITTAELLSIAGEVMRNNKFEEKFKLYDFHIVTGMNIIPTAVVRLNTDGKDFIASEIGVGPVDAALKAIQKIAGEMANIKIREYRLDSITGGSDALAEVSVKVEDKNGNVVSARKAGEDVVVASVQAMMDAINKVMLQKVLYSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHB8</accession>
    <name>A0A6A8FHB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000048">
        <property type="protein sequence ID" value="MRN68356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="193"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="268" mass="27994" checksum="FBCFFD0115F2C8BC" modified="2020-06-17" version="1" fragment="single">MTDWDLLMPGIGLTALGIAGVGLSLAGIAATFLEGMHAVSLLAMFIGLIFLVQGLFKDGFPSSPRAKSATFIVLGFLVTFGIAAAITVSARVPSIYAYIVLMMIIFIPVSILALASYKKTPYLRNLGIILIGVAIVGGSTFYALGVVAPKSSALAGQNGTGSTAHNATATNVTLSKGAPITRVTILPGASAKGNPNFDPKVLNVAKGGGIIWTNNDNVPHTVTSFTDSGKSFDSSLIMPKKTFALNTAKLTEKTYDYFCTLHPFMKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHC1</accession>
    <name>A0A6A8FHC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_03565</name>
        <name evidence="2" type="ORF">FIO04_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000043">
        <property type="protein sequence ID" value="MRN40108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000020">
        <property type="protein sequence ID" value="MRN68202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="63" mass="7221" checksum="472113BA2DEFCBBF" modified="2020-06-17" version="1">MAGRKSQIKCALCGKTIVSNEKEKPTEKQRIVEIIDGTRYIFDTNDCVLMFKKFRGVYGSDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHC7</accession>
    <name>A0A6A8FHC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000126">
        <property type="protein sequence ID" value="MRN68651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="174" mass="19337" checksum="2B0737C7070D577C" modified="2020-06-17" version="1">MYLPSEDSYLLANAVKGYTGKSALEIGVGSGVVLQVLHENFQIVAGTDIDFVSLKYCKDNLSNDIMLACCDAASAFRHKFDLIVTNPPYLPLEDNERKDSAIHGNSNGIETTLNFVESAISVLADNGKMLIIISSLSNDTKIHEFLVQMKLKRRTISNKKLFFERLTTLEISFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHE9</accession>
    <name>A0A6A8FHE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Riboflavin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000203">
        <property type="protein sequence ID" value="MRN68885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="81" mass="8667" checksum="CEAB11D7669F1CCE" modified="2020-06-17" version="1" fragment="single">MYSLFTGIIQGLAEVKSISKIRSNNKSADTKLCINLGGKLKGDLKVGDSVSINGACLTATRISKTVDFEIINETMNRTCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHN9</accession>
    <name>A0A6A8FHN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000074">
        <property type="protein sequence ID" value="MRN68476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="136" mass="15468" checksum="9BD51CAE06978871" modified="2020-06-17" version="1">MSEQILSDICKQILDIDEFIRFAGIANKMGNLEATTYRQGLVPLMTQDETSQYAIQAVLRAATRQDFETNTGRLQYSIGKYEKLIRATVPILLGSNSDYESRFYLLLSFDVGSDAKSIIENKVIPYIEKNKEIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHQ9</accession>
    <name>A0A6A8FHQ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrG</name>
        <name evidence="12" type="ORF">FIO04_01380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="WJXC01000043">
        <property type="protein sequence ID" value="MRN68332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN68332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="562" mass="62212" checksum="FED9127F0A07EC46" modified="2020-06-17" version="1">MKRKFIFITGGVMSGLGKGVVTSSTAKLLQLAGFRVSCVKIDPYVNYDAGTMNPIAHGEVFVTDDGGECDMDVGNYERFLDLALTREHSLTTGRVYSGVIQAEREGRYLGQCVQIIPHVTDAIKGQLRKIAAKEELDVTVVECGGTVGDIESLPFLEALRQMELEDGESNTLFIHVTLAPVLDVVGEQKTKPTQHSVQELRRIGIQPDILAIRCKTPLTAEARHKISLFASVNEDCVISCHDAPSIYKVPEVLASQGMIKVIGKKLLLRKCSPKWGEWRSIAKSFYASTGLVKIAVVGKYATLPDSYVSVYHALSHAAAHIGKKVDIEWIESEKFENGPSSRPNDKGRKNIKNMNNNTNNLFYLKGFDGILIPGGFGKRGSEGIIRAANFARVQNVPYLGICFGFQLAIVGFGRYACGLEEANSTELDPSTKDPVVEFMPEQKTAHDAGGSMRLGSHEITIHSNTNAERIYKTDIIYRRHRHRYEFNQNYRKLLEKRGIVFSGHSDNGQRMEILEIPEHKFYYAVQYHSEFNSRPGNPEQAFDAFVRASATSSTAAAGIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHS1</accession>
    <name>A0A6A8FHS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_03740</name>
        <name evidence="2" type="ORF">FIO04_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000045">
        <property type="protein sequence ID" value="MRN40139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000168">
        <property type="protein sequence ID" value="MRN68784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="195" mass="22501" checksum="7412E461B634B395" modified="2020-06-17" version="1">MMKSNLTDFTKRGFVRLIKPFESSTDDLIKITRAFGIALKTHVGEFRDENKIEPYINHPLKVALVITEELRIYNADLVCAALLHDTTLKGNGELKNDFGEVIHDIVHLVAMPIIGNEEREKTLDKYFYNIANSSVLIRYLILADRLENVRALKNAVHKNKILRYKEETQKYIIPIAEKTNENIVFKLSIALYELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHU5</accession>
    <name>A0A6A8FHU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO03_07535</name>
        <name evidence="4" type="ORF">FIO04_01590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000309">
        <property type="protein sequence ID" value="MRN61877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000051">
        <property type="protein sequence ID" value="MRN68372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="149" mass="17014" checksum="702B0C5C88621256" modified="2020-06-17" version="1">MGESSCIFCDIVKKRLPFVDVYEDDNFLVLMDKYPISRGHTLIIPKNHYDNLLLMPEREVGRLYSLVPIIARAIVPTVKADGFNVGQNNGKAANQIVPHVHVHIIPRFNDDSPNGRWPMRRVASHEELFKIADGIKRFLNPTLVNKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHV5</accession>
    <name>A0A6A8FHV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_11305</name>
        <name evidence="2" type="ORF">FIO04_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000337">
        <property type="protein sequence ID" value="MRN41614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000093">
        <property type="protein sequence ID" value="MRN68546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="131" mass="14444" checksum="D901047CACD0285E" modified="2020-06-17" version="1">MQDEGSDALIARTVRAPSTRTFIIKFLSFQNGCFIVVAEGSNRIGSLYVSVTSSNKVNTAKVIPSKYDSMFINTISERVSSMINGICLVCLHSLKQLHLDDMKAIMGEIMNLVGKEDVGTYNKQNGNFTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHX6</accession>
    <name>A0A6A8FHX6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_05075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000277">
        <property type="protein sequence ID" value="MRN69055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="38" mass="4005" checksum="77E149E843CCA4E2" modified="2020-06-17" version="1" fragment="single">QVEDRGLTQIPAGTATCIGIGPAPTELIDRVTSRLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHZ3</accession>
    <name>A0A6A8FHZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000195">
        <property type="protein sequence ID" value="MRN68864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="679" mass="71415" checksum="B2A9948B3021E41C" modified="2020-06-17" version="1">MVIIVAKSLNHGEQSRSAIRTEIGTRIKTTAITTTKILSFIFAGILFFSSIENANMTTHAQLSSYITTNSTFPNNGSDTDKAPGFLDAYWTNYLSSASSTSNNNNSVKKEVGPGDGASTLAVVLVNRGRSDITGVTGYLTLPSIGFKPIPGKNNGTSQSVASAYSIVKAGGTFVLYFDMNVLKQAKVGGYSTSLSLKYTKINQIGQLITTNTLPFRLTGKVILDAVSENSELIPSTQNQLKILIQNIGSANAAGAVVTVTGITSGNSVTSSNTQSTSSSTSNTNSGNTNTSTTNSPSSSSSPSPSSSSNPAVNIGATAFHIGTIPVNGSAEINPVVYPTASSGETVQNLNLQISYGDAYGNPVGLVILPNPPQSVVNATANNGNALIVPAGKIQDIDFTVANSDNKKPITNVVISLVSQSNSMKILGDSRWTFQSMLAQSKLNLSTKVFASSDLIGKPALFTLTVDYVSAGQSKTDSLNIGTYVSGDIKIRVYDVAINFIGGTPNLIGNLLNEGNTVGLFTTVELVKSNSGKSFIPITPPAQYLGDLSVDSPLPFSMPLNIDNRTLSTIQPGIYPITLKITYSDDLKIPHVLLVNSSVDFEPKHAQSSNGAGGSGGGLSGFGIFVIAAIAAVIVFLFVRRRRSKSKRTKLQSSKDVDPFLDDLSRAPAEKDLSRDLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI13</accession>
    <name>A0A6A8FI13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_01880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000062">
        <property type="protein sequence ID" value="MRN68428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="407" mass="44512" checksum="7AF6DA32A566A0E3" modified="2020-06-17" version="1">MKIYRATIIKSVCHRVNRTILSNLKESPYFQTFCSMSVVITIVMMLVIGNSFPNMALSRSPSQTPSSSGGIPGSSSSRASAPNINGIHNQSSSATPVYSSQAASSILGGNISGRVGSSSKIVMINFDDGYKSQLIYAKPILDKYGFKASFFIVCGKVATQPYWMNWQDIAQLNKDGMDIESHTMTHAHLNKLSTNALTYEIGGSKQCFASHGFNTTILGYPLNLGSDKPSVVNLVAQYYNLGRSGTDPLMFLNCNGYAKDSQTDCSTYLANGKLTHANRYDIRSASFYHISNKHNFSPPEMFQVFLQIVNSQIPSNSNGKINAIPIIVYHNLTTSIQDYTPISHASSTTVDLFAQEMKYLHDNGFKVLLLNQFGFDPTNNVFYIKNVPSSANGNTTKAATLIRGTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI17</accession>
    <name>A0A6A8FI17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000020">
        <property type="protein sequence ID" value="MRN68199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="143" mass="16483" checksum="5CD8F9235C827FF2" modified="2020-06-17" version="1">MARAITMEQKQAFEAGPEIRSSNTYMIVKNERSKRAILVALSETELQKILDATMFNSKSVGQIIRDTEIPHTAAYRKIGWLLEEKLLVVDKIDISEDGKKSSLFRTVLKSFNIKYEYNNVIIEAEQNFDTLKKITERFFSLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI23</accession>
    <name>A0A6A8FI23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000205">
        <property type="protein sequence ID" value="MRN68894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="110" mass="12573" checksum="D75AF23D6785F805" modified="2020-06-17" version="1">MFHPKKRVKALTSSHKVSNQWLLLSYQNILCRHENETYGITGQEPLSYSQAAEILSKEIGKKVFHIDIPEEDTRKEMKEIGMEDWFIGAAMAGFNCIIRGGYASQNDYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI37</accession>
    <name>A0A6A8FI37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_03260</name>
        <name evidence="3" type="ORF">FIO03_02665</name>
        <name evidence="4" type="ORF">FIO04_00355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000037">
        <property type="protein sequence ID" value="MRN40048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000064">
        <property type="protein sequence ID" value="MRN60946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000008">
        <property type="protein sequence ID" value="MRN68133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="237" mass="27269" checksum="CA309EE27BDF341C" modified="2020-06-17" version="1">MKRPFMFFDLGQTLVNEWDFINYFDKEFLEILNAFGARIDSRNYRAVRDSVIRNRQIGHESVRKLVTEVCKLISQPGYGKIITKRLEPQIEEGRRKFLRLFDDAEETLNVLSRQLDLGIIANQTKDIVRLLEDSNISRFFKVKVISSEVGIAKPDPRIFHLAMDLAAVNCPKDCIMVGDRLDTDIRPANALGMKTIRTTNSLFKLQEPMSGLERPTYTIASLSEIPYVLKRIIKTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI57</accession>
    <name>A0A6A8FI57_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidine deaminase</fullName>
            <ecNumber evidence="5">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cdd</name>
        <name evidence="10" type="ORF">FIO04_02105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000073">
        <property type="protein sequence ID" value="MRN68472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="222" mass="25095" checksum="989CD25A37AB36EE" modified="2020-06-17" version="1">MSSPGRNELIEAANSALKNAYSPYSKFRVGAAIRSKEGKIFTGCNIENASYSLAVCAERVALFKAVSEGYKSFDSIAISSSGVKPAFPCGACRQVLMEFNPDLRIYLDQVPTNYQLSDLISHPFSRDQMILNETDRKVLGTRYLELLCEKTQENQGKRFRFSKIEVYGRNRLDAYNRDIVIPLIIQKLRQLGYIEEYENDEISLTPLGRKNCGKQVVVDEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI71</accession>
    <name>A0A6A8FI71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000078">
        <property type="protein sequence ID" value="MRN68488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="189" mass="21501" checksum="B879B0B27062B6BA" modified="2020-06-17" version="1">MLSSDEVKDILYSTIESIGKERIRSDTTSNINLSEKYIDAIMAECITKISDNSNSSNRGETIAVLCEALLHFMLTVSTLPSERKIQVKDNPTIDVVIPSLQSLKRTPDKSIIIEIIRNKMDSDKISQLEFLQPNHKNIWLISVIPFSTTRYRTYGMSTNTGLFHSFSNIIKDINNFLKETGDKSLRFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI97</accession>
    <name>A0A6A8FI97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000135">
        <property type="protein sequence ID" value="MRN68686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="335" mass="38021" checksum="DAC31071DBBEBF8C" modified="2020-06-17" version="1">MDKSIDAFRPKKFDNESLIIHDFLIPLKQIGCIHLTDEIIDYWQSLEKYDFPLINLSSMCLAIETSRFQTEQAEIPIPYAVHIIKMIDMIKYSESMVGGKERINDLKQQLSSLVSNAIRYPEKQADYAVQILKAIVSSNDEFQIGYILHGLDPSLTFNIARGPDFKLCNTRIKVEAKSKLNRTYLGDYNPQPIGLNKEICLRLLARDAVKAGALSTAFNHQGTDIAVVSLSHSEFGDIFAAHVYENKLSDTRENYEFGSAFKDAVKLVNQGKKGVILYSEVIAGYHPYTIGAIASEKETVEQLGLELEKKEKDTKIDSKAPNYYYRNYRSQKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIA7</accession>
    <name>A0A6A8FIA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_06605</name>
        <name evidence="3" type="ORF">FIO03_04850</name>
        <name evidence="4" type="ORF">FIO04_03240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000113">
        <property type="protein sequence ID" value="MRN40696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000151">
        <property type="protein sequence ID" value="MRN61370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000139">
        <property type="protein sequence ID" value="MRN68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="84" mass="8753" checksum="0A862193D95D3C51" modified="2020-06-17" version="1">MENATALAALTFIDISGALIGAAISIAVFIVIAVKSKHILARVPLDKLRLISGILLAITATPLLIYSSGLAAPAWLHWIIPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIC5</accession>
    <name>A0A6A8FIC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_06845</name>
        <name evidence="3" type="ORF">FIO04_03345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000120">
        <property type="protein sequence ID" value="MRN40741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000146">
        <property type="protein sequence ID" value="MRN68716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="144" mass="16199" checksum="F14D152B97AE609D" modified="2020-06-17" version="1">MANPIIKTDSHSDSELRTIFALKNIAVVGMSKNQEKPSNFVPKYLIERGYNVIPVNPTATEVMGRKSYQSITEIPDLIDIVDVFRKPEDVPAVVTEAVKKSGIKVIWMQEGIYNEEAEAKAKENGMDVVSNRCMMAEHVRLFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIC9</accession>
    <name>A0A6A8FIC9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_02495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000093">
        <property type="protein sequence ID" value="MRN68548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="6">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="UDPG_MGDP_dh" evidence="5">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="275" mass="30667" checksum="A2BA4EEEE13BE132" modified="2020-06-17" version="1" fragment="single">MTMPTHEKSVIEQRQRYSPIQFDKVLIVGLGQLGLPVAKYVKERGFDTFGYDISTKAMERAVKIAGIKKAANFSEFDIYILCVSTHKPEDMFSPQIDGLLDIADRISREAKNGALVSIESTIPKGTSNKAFELLNHRLHVVHAPHRWYALEEKEHGVNQLRVIGGVCNCCLRLGVQFYDGNSAGNGEKGGVEDSSFSSLSSSNSSLKSLGIPMHPVAEIEIAEITKVIENAHRYLQIAFAEELYLYCQANNINFPELRDALNTKWNVNILEPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIH0</accession>
    <name>A0A6A8FIH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000363">
        <property type="protein sequence ID" value="MRN69235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="80" mass="7967" checksum="89DC9C8272E05F6A" modified="2020-06-17" version="1" fragment="single">MSFSAGPILQEAIAQAGISSGAGVANQTAANNAMSSYLPPGLAKSIIDQARNTNATKYALQHAIGATTAAMNKTAGMNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK9</accession>
    <name>A0A6A8FIK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_07520</name>
        <name evidence="2" type="ORF">FIO03_06260</name>
        <name evidence="3" type="ORF">FIO04_05205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000144">
        <property type="protein sequence ID" value="MRN40874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000229">
        <property type="protein sequence ID" value="MRN61639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000287">
        <property type="protein sequence ID" value="MRN69081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="58" mass="6690" checksum="A743C69DE18A77DA" modified="2020-06-17" version="1">MSSSSGSNSKFNFMLSEIEWQVVLDALSNTIFSKELPDEARKNAKELFLKLQKELPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIN3</accession>
    <name>A0A6A8FIN3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_00170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000003">
        <property type="protein sequence ID" value="MRN68097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="84"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="381"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="786" mass="90583" checksum="010678D354CBD615" modified="2020-06-17" version="1">MLSGWLFDCYALADKLVFWIKQHNGTTVRLEDTTWSASIYVASDDKSDLYSILNTNDEKIISLIKDHEFISRYEKITDCRKHEILKLTLSDPTKAPILARGIEKLCAKGNIFDKLRFYNVDLPPEQSYFYEHDIFPLAFSKVGNNNYNRHHGSKLSWVLKDNVWSTDYKVPDFRSIYLKVKLRKERKIQRYSDRISSIILSKNNKQDEGFSQSIEIESESEVDIIEELKTEITKKIDPDFIFTDDGDSFTFPYLIHRAEQNGTALILGREPTISLKRNHKDGTSYFSYGKIYFKPTTVRLFGRIHFDTNNSFILNDSGLEGLYEITRICRMSLHTAARASIGKCLSSLQSYYATQKEILIPWKPALAEHFKTFEDLLVADRGGFIFEPERGVHEQVAEFDFVSLYPNIMLKKNLSAETLLCDCCCQDSRMRVPELDYHICEKKIGIIPTSLKIVLDKREKYKELKNNATSNPKLKAIYDARQSSLKWILVTSFGYLGFNNAKFGRIDAHIAVCAFDRQILLQTVKLAEKYGFTVLHGIVDSIWLKKRDGLATTVGTPTTVSPEYHDNYFKLKDVLEQKVGFAISFEGIYKWIVFLNSKINCQLSVANRYFGAFEDGSLKIRGIEARRHDTPPIFYKCQNEILELMAIGNDFKEVRKSIPAVKGIFHKYARLLKENKVPFEELIFTKRISKNSDEYSDRNTIENSAIMNLSYEGRSLKAGEALQYIIVDYYQKHSSKLEKRAIPTELIFDDKTTNAVNYDIQRYTELLADTCNSVTKPFGLTLLAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIR2</accession>
    <name>A0A6A8FIR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000128">
        <property type="protein sequence ID" value="MRN68662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="155" mass="17450" checksum="5FA3F3EC140190C5" modified="2020-06-17" version="1">MDKETTNSIQENIRLVRQAFETINTVDLSDVNKLTSPYYVNLASQGFSYSYRSKIRSPDASIDAVQSLRGIFTGLHHDVQEIIAANASGKHTRTFFVIPPTGRSISYDAIHVYRIEDGKRAEHKAIRDDLSFMMQLGLDGPALLRQTNRLGHNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIR4</accession>
    <name>A0A6A8FIR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000132">
        <property type="protein sequence ID" value="MRN68678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="140" mass="15944" checksum="CAA9F1E7BD5DA1A3" modified="2020-06-17" version="1">MKKEGPSKTTKKGSSGGHRHRVRDLKQKRLKKKPLWHNRSAVKDSRYAIVRVIGHGQFKVDNRTAKKINKIDDELIKIIQTHEQGEKDFARRVDVVLGLVKKVGLPLEHKEIVESDIIVPGADISIEDAKNMFRGKGFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIR8</accession>
    <name>A0A6A8FIR8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cysteine desulfurase</fullName>
            <ecNumber evidence="3 5">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sufS</name>
        <name evidence="7" type="ORF">FIO04_03120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3 5"/>
    <dbReference type="EMBL" id="WJXC01000131">
        <property type="protein sequence ID" value="MRN68672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="29"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="414" mass="46481" checksum="14C7829CF36BDADB" modified="2020-06-17" version="1">MQKSALSVYEIRQDFPILKRKVGDNKTLVYLDNAATTQKPFSVINAIHDYYSNYNANIHRAVHQLGEEATLAYEQTREKVAKFINASSTEEIIFTRNATEAINLVSYAWGRKNVNDGQSIVITEMEHHSNIVPWQILSREKNAKLCYIGVDDRGYLRMEDYKSFLDKSNVGLISLSEMSNVLGTIVPLNEIIKMAHRDGIPVLVDAAQSVPHLPVDVQKTDCDFLAFSAHKMLGPTGVGILYVKRKILEEMPPFIGGGDMIKEVHKQNTVYNDLPYRFEGGTPNIAGVIGFGAALDYLNRIGMNRVRDHEIDITKYAMSALADIKDVILYGPLDANDRGGVISFNIADIHPHDLATIMNERGVAIRSGHHCAQVLMERLDVPATSRASFYIYNTKEEVDIFIDALHNARRIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIR9</accession>
    <name>A0A6A8FIR9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000409">
        <property type="protein sequence ID" value="MRN69315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="87" mass="9796" checksum="41BEE8C07FA2901A" modified="2020-06-17" version="1">MQMKESAEGRLKLIEVNPRMGGGTIFTSLAGANFPALLLDMIEGRQISVPTISEITIIRYFEEFVLRSEEERIHVGANLLSKTRFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS8</accession>
    <name>A0A6A8FIS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000068">
        <property type="protein sequence ID" value="MRN68449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="146" mass="16484" checksum="FB20D020451FBB2B" modified="2020-06-17" version="1">MSYTLIFGNNFISESPKSIKIYDRILFSLGENSLGPYLSAEISDNTGKQLIKVDHNACIYYHEKLINKSREPEHILIININGENILESRVLDKKTILVSGMFAFPEFILIATQNYIVMPNGKRLMHSRINAKNGDVAIAEDGLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIT5</accession>
    <name>A0A6A8FIT5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_03880</name>
        <name evidence="3" type="ORF">FIO04_03220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000109">
        <property type="protein sequence ID" value="MRN61180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000138">
        <property type="protein sequence ID" value="MRN68692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="88" mass="10063" checksum="3C8DA386AAD732FD" modified="2020-06-17" version="1">MKQTDTHLQHVNQNIHAKTPNGCEECLQIGSDWVHLRLCLSCGHVGCCDSSPNKHATKHFKTTEHPIIKSFEPGENWEWCYVDKTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY9</accession>
    <name>A0A6A8FIY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000066">
        <property type="protein sequence ID" value="MRN68443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="608" mass="66248" checksum="522715E3FB371465" modified="2020-06-17" version="1">MKAQSFRPSLKFNGKIVVITGSGTGIGQAIAKKFAENGAHIVIMGRRREPLELTSAILSDTVKAAGSTGKVRSFHGVDVADEVGINNMFKVIKEEFGTVDIIINNAGVSGPVKVFTSATHAEFKECVAIHLTGAFWTSLQGIKSMERGGKIITIATFFTEENRYEQRPYRFRAPYTSAQGSKNRLAEALAWELVEKGIKSIATNPGPVHSDRIYKTVYPKAAAEFLRIGGYQGLTSIEIERVLTILLQLLGQPEPIVSEGIREAANEISKSQKSNSTDSFSSVAKMEAVLSGLLAKVQEIAEKIQFNTAKMIVDGEFLTQDDVANMVLNLCDDVISKLINGRVVPNDRVFYPVKPLVGTAILGTNLLHPKIKDKVVVITITSSSEKDLDRANKIAAALSSSNVKQVVILAKNPADLTRFRGFHSHLVNLSEEKSVRMIFETVRSKFGSLDALIHLTGDYDYDLPFSSLARAQWDSLVDNFINIPGLIVKEAVNMMAPEGAADEPVKFRGSKGVVVIIGPDAPVGKKISGTVRARSEVFRGALRPYTATVNQELADVLGSDIRLYLVLPGNIEGEPPDTEMLKNSLTHLLSVSSLKRSEVIFYIDESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ09</accession>
    <name>A0A6A8FJ09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000362">
        <property type="protein sequence ID" value="MRN69231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="306" mass="33871" checksum="88ABB6C9A52613DF" modified="2020-06-17" version="1">MKILVTGGAGFIGSNIANTMSREKNTAVVAFDDLSLGNPINLSQSVKFVEGSVMDFELILEASKGCDYIFHSAAKSSSPMFQDDPREGVEVNALGFMNVMESAKRNHVKKVIFASSSSMYNGLPIPFKESQTITPKTFYEASFYCREILAKSYYLENGLNSIGLRYFSVYGPNEKHKGKFANNISQFLWNITNGESPTIYGDGTQTRDFTFIDDVVQANILALQSEEKEFGIYNIGTGTETSFSRIVEIINQRLGTDIRATYVDNPIKNYVQKTKADISLAKSELGYEAKCRSLEDGIAALIKKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ15</accession>
    <name>A0A6A8FJ15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000018">
        <property type="protein sequence ID" value="MRN68187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="2">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="290" mass="33583" checksum="D7DDDFA2D8D51647" modified="2020-06-17" version="1">MVKKWAAGGDMEDALIAAKNCNMKGQKAILNYLGEDLTEEERINRTIKEYSNLLERLYLSQIEGCISVKPSQLGLSVSYELCLKNLRALTKRAIEFGRFIWIDMESSKYTDDTLMLYLELIGHHHDIGVVLQSALRRSASDLLHLIEVGGKVRLVKGAYHENEQIAFASHDEVNANYIKLLDILFNRNYKVEKRLLNKESEDLKFAVATHDSKLIEHTIGLWKTSKIGIKNFEFEFLKGIRDELKRDLVEEGFRVAEYIPYGDEWLPYSVRRLRERKRNIFLLARSLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ52</accession>
    <name>A0A6A8FJ52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000513">
        <property type="protein sequence ID" value="MRN69475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="144" mass="15373" checksum="0DC331EF867B2551" modified="2020-06-17" version="1">MIKFLEGIQNRPIIAIVCTILLLIGSCSVVLQNVGADQSPQTRSKLGYNDGFKNAGCDFKQCHGHGYDRIVPTGHTNPYNNGYSKGYQDGWNKASGGVGGKSQQSIHNGTSNVNATTAKSQEVPNNNDVCDPVHQFCAMTTAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ55</accession>
    <name>A0A6A8FJ55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="60" mass="6309" checksum="0BF013429B610CD1" modified="2020-06-17" version="1">MKKFNGRVVLITGGSSGIGKQVAIDFANNGARAVIFVARSERSLRGSKFSSAGNYGSILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ72</accession>
    <name>A0A6A8FJ72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000189">
        <property type="protein sequence ID" value="MRN68852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3" evidence="1">
        <location>
            <begin position="199"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="509" mass="57567" checksum="92005A052501ABA0" modified="2020-06-17" version="1">MTNYRGNFLYGFIACGPYELVPEFVFDKLFCPSVETDKNTGGVKVAQCGLRRIEGALLKEYSREDIFLAHPEMLEKCIGPETKVVGINVMDPLGMAPVTTTMSPENLSYVAMKFKKMCASIIQLKKKYNFKVAVGGNGAWELAKPDRMKIHGIDTVVIGEADELALDLFHDLEAGDAPELLHTFVRNIENIPMIRGPTINSLIEAMRGCGRGCDFCDVNKRSKKDIPLERLQAEAKINLKYGFDSIWLQSDEMLLYGCDNRDFIPNADVILGLWKGLKEVGANFIGTTHMTLSAVASSPDLIKKLSQVNNMDNNGRWLATNLGIETVAPRMVKKHLGVKTKPFRPEEWGAVVREGARILNQNHWFPALTLIIGWPDETTDETQYTIDLIEDFRQMNMRGLLAPLLYQDFSEKNSMHFGNLNEAQFTLFWKCWQHNLWVINDIIPIIIRNKTYGPAMKVFMALLIKAGTWGIMRYLRGLSKTLFNGQTPEDIIEIYARKRSVTTSPMPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC1</accession>
    <name>A0A6A8FJC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000216">
        <property type="protein sequence ID" value="MRN68918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="146" mass="16980" checksum="E58CB20CEF15321A" modified="2020-06-17" version="1">MTFDSEPQTRESKEFLFEAKFGYLTDESGDARASCSRIMNIYNTYLSGWFFRLLKSDEANRLETLFRVKFSPFDKEFVLAVDRTNEFLTNSGELIYPLVVEGDLQQAQQKVKEFSNDLDLPLTDLRNELKIFLSMEADFLEKSKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC7</accession>
    <name>A0A6A8FJC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000560">
        <property type="protein sequence ID" value="MRN69535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="180" mass="21273" checksum="5FA6AEA6A220F8AB" modified="2020-06-17" version="1">MAKDAKRKSESESITFRVERNVLDKLRAEAERKMESVNILGNQIFKEYVYWHSPAAEAGMMYTSKKNLVRIMDKLTEEQINQIVDEHLKDEFIGQIEMITGEYNIISYLRAVENWMSASHIHYRHDVKDRIHTYVILHEMGKKWSYFFERMFKGAFKTMKPKDAEVNATDDTIVLKLCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE7</accession>
    <name>A0A6A8FJE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000128">
        <property type="protein sequence ID" value="MRN68659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="178" mass="19425" checksum="F0257936E95330C6" modified="2020-06-17" version="1" fragment="single">MNSLFPILAIVRKDISVWLRQPTSIAATVLPAIAFMVILYFGAQAVGRNPVALIVQDSGPHAQELINILSDSGAFKVAMITIAPQKAEDALKQVKVAAVITIPSNFDAAYNAKKPDPVTIHINNLNLDFTNDLRRSLPAAITMFYAGQSAINGNNSPIQIRVKETDLRSQDIDLLRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF5</accession>
    <name>A0A6A8FJF5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000273">
        <property type="protein sequence ID" value="MRN69046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="114" mass="12331" checksum="F170B6BCD99C05ED" modified="2020-06-17" version="1">MSNLLSNAVKFIKEGGRGGTVIVDIEKKRVRRTGQENKEYDAVVVSIKDDGPGIDPEIMPRLFTKFAAKSDIGTGLGLFISKSIIEAHGGKIWAENNLDGKGATFTFSLPVTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG9</accession>
    <name>A0A6A8FJG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000282">
        <property type="protein sequence ID" value="MRN69066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="27"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="295" mass="32190" checksum="D737369F4D103E2A" modified="2020-06-17" version="1">MASPLNLAVIVKLEPDFSEGSVSYNSDGTLNRAETKSILGPHSAIASAAAFYAKVKYGAVISVATMGPPIADSALQQAQLISDADSLHLYSDRIFSGADTLATAEVLKTGIKKMEGTGEMDIVFSGHRASDGETGQTGPQTAWKLGYTFLGNVICYDVDIEKRILTAKRLITLQGTPDVIEEIEAPLPVFITVDPSYRSVFNTVSLRLASVKYQKEAEQRAQNYKNYLKIFNAQQLEVDPKFVGLPGSPTIVYKVERIPKARASRRAEVIDGSDQQQLRRVAEKIHEIVGRVVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ5</accession>
    <name>A0A6A8FJJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000246">
        <property type="protein sequence ID" value="MRN68988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="238" mass="27570" checksum="03BB8EB16E798F18" modified="2020-06-17" version="1">MSVDLGRNVPLQIQRQLRKECFFGCALCGSPLLKYAHIVPYNRIQAFLPENMISLCPPHYGKYDNGDLSESYLRDAKRDPHNKLHPQDAFFVESQELVINVGKSKFINTHRVLVIDDFDLITVSRDNGKYFLLDINFFDKINNLIATVLENSWVSENSVGWNINYSPQKFLAIQNPQRNTTFEITIENTELFITAMMYYNNYPIRVTRNEILLNENEIGIEFKNSVLKNYDVAIAAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN3</accession>
    <name>A0A6A8FJN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000519">
        <property type="protein sequence ID" value="MRN69484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="200" mass="22639" checksum="BCC2C549493CE83A" modified="2020-06-17" version="1">MYSRDNHPELLYPKKEEVSSIEEERQYEEIVQTNVFNVMLNRRSQRKFENKAVEDWKIEMILAAADTAPTAGGFQGFEIFHVNSSEIKVKLVEAANKQPYVNAPLVLVFCMNSERVKMNFPPNILKKFSLQDATLAAAYSQLAAHALGLSSIWIGMINEDEVMEALGTNLVPATILCLGYPQKMLQPKPKRSLIELIHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ1</accession>
    <name>A0A6A8FJQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000141">
        <property type="protein sequence ID" value="MRN68703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="94" mass="11023" checksum="BD6B0DBF72CC09FE" modified="2020-06-17" version="1">MEQIGYRQIIDYDIDILYFINQSIGKEIGFEKSNHISMPYALTLLHYYADLEYHMTGLCEFIPNIVKEKLIKLLKIYSMIANGFWIQIAIKNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR1</accession>
    <name>A0A6A8FJR1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="1">1.8.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_02025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000069">
        <property type="protein sequence ID" value="MRN68457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="3">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="115" mass="13596" checksum="A5BAF820F6733208" modified="2020-06-17" version="1" fragment="single">LLVAVRLLPVAAHNPTTLNRQGNDVGTQYRSAIFYHDEKQKEIAEKSKKELEKEDVYKDSIVTEITPFKNFYVAEDYHKNYYEKHQDAPYCNFVIEPKIHKLLQQYGNDVKEEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS7</accession>
    <name>A0A6A8FJS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_07530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000559">
        <property type="protein sequence ID" value="MRN69534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="5">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="216" mass="24498" checksum="75FBC60A6E276BDC" modified="2020-06-17" version="1">MKCAFGYLRVSTEEQTILNQKMVLQKWADERGYQVIDFFEDSAVSGKIPAVKRKAFQELLELVRIAPIDAILVYELSRVGRTFWDTLDAIKAIEEYAPLISCSPRESFLQNTEPSVRRLMIGILTWVAEREREMLVQRTKDGMARAKASGKAIGRPHKTLDKDYLIKLLSANTPRSKIARALGVSKATLYKELRELTACYPVQSSAKDEAAHLTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJT6</accession>
    <name>A0A6A8FJT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="8">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO02_10295</name>
        <name evidence="8" type="ORF">FIO04_03485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="8"/>
    <dbReference type="EMBL" id="WJXE01000269">
        <property type="protein sequence ID" value="MRN41417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000155">
        <property type="protein sequence ID" value="MRN68743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="128"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="298"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN41417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="373" mass="42683" checksum="CD6D4CF3162B96A1" modified="2020-06-17" version="1">MGMQIVKESDDDRLMTLSVGPQHPGSGHFRFIVKLDGDYIVHCDPDPGYVHRGEEKMAEYRNFIQNIPHLERPVIHDSTNITYSYSLAVEELTGIEVPRRGQFIRAIASELNRQVYTLYWLGIYGIFLGHSTMFMWPMGDRELFIDLLEALTGARVTHAFNIPGGVRNDVPNGFKDRCLRQITYYEKRLKEYEDIFYNNPLVRQRTEGVGILTKEDAIRLGVTGSVLRASGVPYDIRKAEPYDVYNEIDFKVQYMKTADSFARAYVPFLDMRESCHILRQLLDKMPEAGEVRAKLQANPRGPPGEAYRRVESGRGALGYYIISDGTPKPYRVKISVGSFRNMLALPHLLVGAKMGDMPVIYWALNYWPVEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV8</accession>
    <name>A0A6A8FJV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000179">
        <property type="protein sequence ID" value="MRN68819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="175" mass="18842" checksum="6138A9C3C6525CB6" modified="2020-06-17" version="1" fragment="single">MVVIILATSVLVSILNEIDTASPTNTAVAAVAPVISKNNNKVTVDKFGIREIYPTKSNGTEWYINMSSPLNDKSFSLSGGGEKTSNSSLANATSLNGHLIKEPDGSYQVYGVRKTGKYDFSVRMNVNASDIAKWWKNIEMTGYVKVVTDTSSGAALDWYARGRLHISSSPCEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJX8</accession>
    <name>A0A6A8FJX8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000045">
        <property type="protein sequence ID" value="MRN68340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="112" mass="12536" checksum="7C3778B492419C53" modified="2020-06-17" version="1">MIKKIDISDNRANKEPDAVIILLESGKSESQGFIVQHIELRQYIESGDPRLGEYSLITVLIKTDKGIVEMKYDEGYRGSAALKSAADFLSQYVGYASLICRTLIELQDYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJZ4</accession>
    <name>A0A6A8FJZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1297 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000320">
        <property type="protein sequence ID" value="MRN69148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009720">
        <property type="entry name" value="IMP_biosynth_PurP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="PTHR38147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06973">
        <property type="entry name" value="DUF1297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1297" evidence="1">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="118" mass="13106" checksum="E4591F92828C1CAC" modified="2020-06-17" version="1" fragment="single">RLAVELEPSYNVVGNMPIVLRESLLGEVYAMGERFVEAARRLVPPGMTGPFCLEGIYDREGKFITFEFSARIVAGTNLYLDGSPYSGLIFNEPMSMGRRVAREIKIACENGVLQQITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK00</accession>
    <name>A0A6A8FK00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000566">
        <property type="protein sequence ID" value="MRN69541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="205" mass="22842" checksum="A29A175B0828A0C9" modified="2020-06-17" version="1" fragment="single">IIQIPVGQMDNFTYMLADEDNGEAAVIDPSWDLEKIFDVVKKNGWNIKYIINTHTHFDHILGNQQIAAVTEAKIIQHKNSTQPNDIPVEDGQIISIGKIMIRIIHTPGHSKDSISLVVNNELVFTGDTLFIGNCGRVDLPGSDASEMYDSLFRKIANLDDSMIVYPGHNYGSTQTSTIGQEKKTNYVLKARSKGDFLRFMASADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK16</accession>
    <name>A0A6A8FK16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000096">
        <property type="protein sequence ID" value="MRN68557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="53" mass="6002" checksum="674FB4C724C2D507" modified="2020-06-17" version="1">MKASLVNEHMPILTVMETLTSLIITKEIYGRVELLSLSIGVLLKMTNMIKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK83</accession>
    <name>A0A6A8FK83_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000070">
        <property type="protein sequence ID" value="MRN68460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="335" mass="38371" checksum="C9C70A566491FE4B" modified="2020-06-17" version="1">MIINSNNSKMLPESEIMENVHRFFATEVALITTNGSKYGPNVMAVEWTMQIAYDPILIAIFIHDSPTYWNIQETNVFAVNMASEEQSELVNIAGGYSGIEIQKLTIPNTFDTYPSKYIDVPMIKNCTVNAECKVKAIQTFADHIMVVGEVVRATFDEKELPLIYTRGSYRRLSRQKISGGRKRIVVSHSHFVEFKAMSYGQFILKAAVAVIRDENNKLLLITHQSFGNFLMLPMVSVKRGSNYVDTLHKYLETIGIITEIESILGIERVILMSNYPDGQTEDKKESKISRELRANFISFSCKMKSMNEENRYLRKWLDKAPRNTLLRTLVNCRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK87</accession>
    <name>A0A6A8FK87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000372">
        <property type="protein sequence ID" value="MRN69248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="60" mass="7056" checksum="7F6983E4230433E6" modified="2020-06-17" version="1">MFVCKDENMKEVTHSLLDSYHSLCIDKQAIILGEIEARERRLKYTADDIDKVTTKRENQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK90</accession>
    <name>A0A6A8FK90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxycytidylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_07510</name>
        <name evidence="4" type="ORF">FIO03_06250</name>
        <name evidence="5" type="ORF">FIO04_05920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
            <strain evidence="4">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000144">
        <property type="protein sequence ID" value="MRN40872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000229">
        <property type="protein sequence ID" value="MRN61637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000358">
        <property type="protein sequence ID" value="MRN69222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN40872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN61637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="180" mass="19819" checksum="6581085AE61AFA8D" modified="2020-06-17" version="1">MKRPDWDTYFMLHSEIAKLRSNCVTRHIGAVIVKDNRQIATGYNGTPSGVKNCFEGGCYRCMARIRGEIKSGEFLERCMCTHAEANAIMQCALFGNAGSTRGASLYSTFAPCLECSKMAVSVGIKRIVVLADYPEDGTQLLSEANIKLVKLNPDLLQPWIAVITKDPETSAKEANTLESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKF7</accession>
    <name>A0A6A8FKF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_02400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000088">
        <property type="protein sequence ID" value="MRN68530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="611"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="784" mass="90857" checksum="1963181C0CEFC41D" modified="2020-06-17" version="1">MVLRIEAKLWNPALENIILQKWANNAIYKFSIDESRKAFVIDTPPPYPSGRPWHIGAAAHYSQIDMIARTSRMMGYNVLFPIGIDRNGLPVEIYTEKKYKIVMRKTDREKFLELCAHALDDLEDEMIQIMKTLGISGNFEEYYRTDSKEFRALTQSTFIYLWKQNLIYRANRPNNYCPQCATTIADAEISYETIPTKLIYIRFRIIETGDSIVVASTRPELLFACQSIIVNPKDERYLTLIDKHALVPIFDREVKIIAHPSAKPEFGSGVVMVCSYGDENDVRIFRELGLKEIVSLDENGRTTSAAGAYANLSVNQARTKIIEELRNIGILEKEENIMHRTPICERSRTPVEIISLEDYYVKQINYVPVLKELANKITFHPDRHKQILLDWLNSIAIDWPVTRRRFYGTEVPIWYCNNCKYPNLPDEGGYYRPWKEKPPFEKCSSCGCTEFIGEDRTFDTWLDSSITPLFITKYKNNSQFYNYTYPTTIRPQGKDIIRTWLYYTMLRCFQLTSRLPWSDAWIMGYGLDEKGEKMSKSKGNVIDPLPLIRKYGADVFRFWAAAESNLGYDFRCSEQRITTAKNFLSKIWNIGRFLSSFDVILEMPATLAASDRWIIGELSQLIDKCKEGYSNFNFFIPANGIREFTWNVFAAHYIEMIKGRIYDTADQSMQRSAIFTSQKCFSTILVLLAPICPFITEELWTKIYSAESIHLQQMPQPLDHYGELTKYTKLIMDFNSMVWNKKKATISDETGKPLSLKDSIGSIIIPPDLDLFKEDLKTMHNLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKG2</accession>
    <name>A0A6A8FKG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000402">
        <property type="protein sequence ID" value="MRN69302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="178" mass="19491" checksum="CA7331097B89D415" modified="2020-06-17" version="1">MIRFFLQIGSMVNQKALCIVPVLLLSVTLIFESQLHVIYAGNNSISSGNQINPIATRNNTGTNNSTLQISTDKLTYVPGETVIVTIKNNLRFPLEFADSLLGLNIENVKTGQKAGLLAAQVISELKPMESKTFQWDQKDTNANQVEPGIYKAQTSSVRNNTSNNTQLSTAKTTFTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKG4</accession>
    <name>A0A6A8FKG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000248">
        <property type="protein sequence ID" value="MRN68993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="241" mass="28574" checksum="BE96420DDA368210" modified="2020-06-17" version="1">MNYLTSRINISKFRLSSGLQYYLQKYRQMLDIPRLCRALAVPGKIAKNFIEDKKTKQYTERLKDLEYLTDKTIHTLENYVKNENDKLITANLNNNQKEAIYTDINELAVYLNMYYDIETVRSDPLISNEYPSGNPFDDVVDVMIYGAIIIRFKYVSRDQSSPQEKLVSYHLMDFKDKKVLGVHIQGDDKFSMYKQWGQGDERLVPIYPDYNNTVIRWGREELLEYLLKGKGDREDRRELLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKG7</accession>
    <name>A0A6A8FKG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_07655</name>
        <name evidence="3" type="ORF">FIO03_01855</name>
        <name evidence="4" type="ORF">FIO04_03145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000149">
        <property type="protein sequence ID" value="MRN40900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000039">
        <property type="protein sequence ID" value="MRN60788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000132">
        <property type="protein sequence ID" value="MRN68677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="84" mass="9607" checksum="16F7BF238839D20F" modified="2020-06-17" version="1">MPKGFGSKSGNTGKRSFNEWWENVPSDLRQKARKGDEQNKPLLNQVNYVLLHLGLAGKHDAKPTHEELKDWLHSGQVDVLRMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKK6</accession>
    <name>A0A6A8FKK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">30S ribosomal protein S4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_06675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000443">
        <property type="protein sequence ID" value="MRN69368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S4" evidence="6">
        <location>
            <begin position="67"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="134" mass="15087" checksum="AC8BFCD03D0AF191" modified="2020-06-17" version="1" fragment="single">NKRELWKAQTEVARFRNQARALLSLATEARTERENRLLKSLNRLGLVNESASLDDILNLKIEDLLERRLQTIVMKKSGTKSPHQARQVVVHGHVSIGDRIVNLPGYLVKREEEQLILLHVNVLGPLSSAPAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKL7</accession>
    <name>A0A6A8FKL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000440">
        <property type="protein sequence ID" value="MRN69362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046038">
        <property type="entry name" value="DUF5996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19459">
        <property type="entry name" value="DUF5996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="304" mass="34866" checksum="0936BA76C098DB61" modified="2020-06-17" version="1">MKPMTTNPWPALPLAEWKDTYDTLHMWTQIVGKIRLALTPFVNHWWNATLYVTPRGLTTSAMPYNGRLFQIDFDFIAQLLLIVTSDDSTKTIALRPRSVAEFYEETMAALGSLGMPVTIWTTPVEVQDRIPFEQDQKHVAYDPEYAQRVWRILAQASRVLTEFRSRFIGKVSPLHFFWGAFDLAVTRFSGRTAPPHPGAPNCARFVQVEAYSHEVSSCGFWPGGGLVDEPVFYSYAYPEPQGFKDYPIQPPEAFYHTEMREFLLPYDVVRTAKLPDEVLLAFLQSTYEAAATLAKWDRRALERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKN3</accession>
    <name>A0A6A8FKN3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps28e</name>
        <name evidence="4" type="ORF">FIO02_04855</name>
        <name evidence="5" type="ORF">FIO03_03640</name>
        <name evidence="6" type="ORF">FIO04_05165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000068">
        <property type="protein sequence ID" value="MRN40355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000099">
        <property type="protein sequence ID" value="MRN61133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000285">
        <property type="protein sequence ID" value="MRN69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_S28e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN40355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN61133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="71" mass="8059" checksum="AD1662C2B70E51DE" modified="2020-06-17" version="1">MSKTSEERVIPAEVIQIVGRTGIAGEVIQVRVRVLEGKDKGRILTRNVKGSVRMNDILMLRETEREARKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKR1</accession>
    <name>A0A6A8FKR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ORF">FIO04_02960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000122">
        <property type="protein sequence ID" value="MRN68640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="200" mass="21948" checksum="B17ED3A5EEE56C18" modified="2020-06-17" version="1">MIQGLAEVKSISKIRSNYKSADTKLCINLGGKLKGDLKVGDSLSINGACLTATRISKTVDFEIINETMNRTCLGLLKAGDKVNIERSLRLSDRLDGHFLLGHVDGIGTIKKIMKSPIQTKVWIRIQNKKLMSWIVPKGSIAIDGVSLTIIDIEDKDKMISVALIPHTLATTTLTLKSIGEKVNVETDIIGKYLSRHLPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKU8</accession>
    <name>A0A6A8FKU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_03765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000172">
        <property type="protein sequence ID" value="MRN68797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="276" mass="30464" checksum="4B223334FAB09F6B" modified="2020-06-17" version="1">MQDLVAVSVKNLTYTYKVSSTSFSSNVLDNISFSVNKGDLLGVIGPNGAGKTTLFSCMLGLFKDYQGEVRIFGHDIRKNNNLILQSIGYIPQQKSIEQGFPATVQEIVSLGLIGKKNGSKEKVDSALEMVDLSGQNHRRIGELSGGQQQRVLIAKALVSEPKLLILDEPTTSVDVETQNKFYTLVKNLNLKNNLSIIWASHDLDAVNKIANKVMCLNRSMFFHGDSSEFFGSNELIRMYSESSMQLHMRSHSNQNKNLHSGYSQGDANAHDDGMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKW5</accession>
    <name>A0A6A8FKW5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_03705</name>
        <name evidence="2" type="ORF">FIO04_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000045">
        <property type="protein sequence ID" value="MRN40133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000133">
        <property type="protein sequence ID" value="MRN68680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="314" mass="34305" checksum="EBA7E8A6BC91D0AF" modified="2020-06-17" version="1">MKLQNVLDGKKIVFSSYEKNHVPLGGWGLRCNPGCEKTIKPIRPVNEAALVAAVDSSSIRIAETEDGSLYAVKSGIAFAINGQAIMHFKIGPILVYLNKETIKTSELDHRLAKLVLFDGESARRLIRLRVERAIQIKLSNHFIKSIIVVDGALKSSPFENKNQSITTVAENCSVRKNVLLGISKSTSFKLLDKVSAPLTNINEAAYMDIEMIIQSLSRSTIGNNLLVKLGNNNSPILRADIVCPEGDIDNSIGKLLTNDSMAGGYPETLRLAHHVSTFSNTEIACLRGHLLSNYDVTELPSEDIRKTLLGSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKY9</accession>
    <name>A0A6A8FKY9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps19p</name>
        <name evidence="7" type="ORF">FIO03_03555</name>
        <name evidence="8" type="ORF">FIO04_07210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
            <strain evidence="7">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000098">
        <property type="protein sequence ID" value="MRN61116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000511">
        <property type="protein sequence ID" value="MRN69472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN61116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="135" mass="15429" checksum="4E214448F7A11804" modified="2020-06-17" version="1">MVREFKFKGYSPEQLQTLSIEALIPLLNARVRRSLDKRVGKYMNDAKRKLREEIKLAREGKLKGELKTHVRDMIILPDMIGLSVKVHNGKEFFAVNIRPEMIGHYLGEYAITNRRVQHGAPGVGASRSSLYVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKZ3</accession>
    <name>A0A6A8FKZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000144">
        <property type="protein sequence ID" value="MRN68710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="141" mass="15528" checksum="6844709B6D2EF2DF" modified="2020-06-17" version="1">MKKEVVRDIMTRHVVSIAEASTALEAAKLMTEKAISSLIVTKDDYPIGILTENDFVKKICIKELQPSNVIVEDIMSKIRTYADPETPIEVAVQRMINHKIHRLPVMVGGNVIGIITVTDLAEHLRTILLIGGGLEGQTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKZ8</accession>
    <name>A0A6A8FKZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000517">
        <property type="protein sequence ID" value="MRN69482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="239" mass="26524" checksum="C0AEA8031B35C2BC" modified="2020-06-17" version="1">MCDGLGISGANENSDETLQQYRNLVRVRNTRATKDKKKMLTAIHAAESENTMEFSKSHTGRTEVARIMKCLNPDIIIHMTHATKKDISMVARNRTGIVVCPRANGIVGAGVPRVAKMLDLGCIIGIGTDNVMLNSPDILRELDYIWKVSRSVERIFLNARDILKMATVNNAEILRLNSGYIQSGRAADIIFIDKSHVDLYPIHNPFATIVHRATEASIKAVMIDGRFVDGAQFEFANNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL09</accession>
    <name>A0A6A8FL09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000524">
        <property type="protein sequence ID" value="MRN69492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="36" mass="3833" checksum="BA30CEA993BC59E1" modified="2020-06-17" version="1" fragment="single">MKIGLAGLGLMGAAIARRLIDAGHLITVYNRHSIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL38</accession>
    <name>A0A6A8FL38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_07470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000550">
        <property type="protein sequence ID" value="MRN69522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="9">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="8">
        <location>
            <begin position="199"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN69522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="314" mass="36636" checksum="7D6AA9A85C86FB81" modified="2020-06-17" version="1" fragment="single">MPKAENLVRFLNNKLHIEKIQSFDDQFGIFKRLYHRYDIVFIFESLIGPKELSEFSIIGFDPELTITCDTKKFSISDRSGVTKVTKVVDPLVQLREVVPKVSDNRFRYLGGAVGYVSYDAVRFWDRLPLQNMKKHHFPLLEFGIFTDGILYNHVEKQAYYFSIRPNSRINEVKDLISESRALQEESKFSYSTPERNLTREQFIEKVNKSKKYIYDGDVFQVVLSKRMTFKISGDLLTVYEKLRDINPSPYMYFFKMGGKHIIGSSPEMLLRVTGDHLETFPIAGTRPVADDDKRNQQLSRDLLNDEKEVAEHTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL43</accession>
    <name>A0A6A8FL43_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000162">
        <property type="protein sequence ID" value="MRN68760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="57" mass="6739" checksum="03924A94D4902C54" modified="2020-06-17" version="1">MPPRVEYRLTTKGQELVESVIAMLEWMRKWSSKAKSKKYVMKCSDIRVTLAKFQPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL67</accession>
    <name>A0A6A8FL67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase/arogenate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000377">
        <property type="protein sequence ID" value="MRN69259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="294" mass="33326" checksum="4618BE2E36BF583B" modified="2020-06-17" version="1">MIKRIAIIGAGGRMGTWFSKYFSLRKGTTLILYDINAYSLKGSANTTVCEDLVHCVDRADLVMVCVPISEVPHIIQECATKMKPGAILVEISSIKNRSYKELKRVPNHVKPLCIHPMFGPAAPSLNLMKIILIPVRNATNELRILKELFEGSVVSIIHDAKTHDRIMSIILGLTYFTNLVFASFVSKQDYQSLKQFSGTTFRIQSLLCTSILLDEPDLILALLSQNSTVQKQIRKYLFEAKKLERLLLGHNQFKMKSTLEKLKSFYQEQQSLELSYTQMYRIISYLNKSDGGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL72</accession>
    <name>A0A6A8FL72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000574">
        <property type="protein sequence ID" value="MRN69552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="46" mass="4980" checksum="736B8C9FFCED7CAA" modified="2020-06-17" version="1" fragment="single">MADILHKIDIDATPDKVYSAVSSNQGLKSWWTTDVSGDSKKGSVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLA3</accession>
    <name>A0A6A8FLA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000232">
        <property type="protein sequence ID" value="MRN68957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="101" mass="11530" checksum="70B3BC5EDEF99860" modified="2020-06-17" version="1">MGRTIPSFRIATVAEEKEWKSFRNSLDKSDRKIFDQMFSVARMYNSASSYTTKPVRIQPILMSIIFHHYKQLVKLSKQIKESKGSSISSLTSVSEISLPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLE0</accession>
    <name>A0A6A8FLE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_05220</name>
        <name evidence="3" type="ORF">FIO03_00380</name>
        <name evidence="4" type="ORF">FIO04_06525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000077">
        <property type="protein sequence ID" value="MRN40427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000006">
        <property type="protein sequence ID" value="MRN60499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000424">
        <property type="protein sequence ID" value="MRN69339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN60499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="101" mass="11300" checksum="71C270F2195D282E" modified="2020-06-17" version="1">MNNNKQFLTNQLVWLGISFGISLTISMLLPFPISLAVIFGVFILLNLYMRRIMMRKTGSMTRSMFGSGDNSSLKYYCMSCGTQHKQAACPKCGSKMKRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLG1</accession>
    <name>A0A6A8FLG1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000441">
        <property type="protein sequence ID" value="MRN69363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TFIIB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="97" mass="10745" checksum="9B86DB96FA4C1CC0" modified="2020-06-17" version="1">MKIPIVDPIKCIVRVANKAEISEKTKHRAINLMYTVIKNEISAGKDPMGLAATVIYASCISTGEIKTQKEVANAADITDMTLRTRLKDLKHHLDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLJ5</accession>
    <name>A0A6A8FLJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000458">
        <property type="protein sequence ID" value="MRN69389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="211" mass="23750" checksum="0C7FD9D2E9F30672" modified="2020-06-17" version="1">MSRKQAVVAFGAHPDDIEIGMGGTIAKLSALGYDVNLVVATLPNFVKIDKKEERRNESTMSAKVMGCKTPEFLDLTPDEITFGRRFVTKVDEIINRHKPEVVFTQWIGDSHQDHQALTKAVIAASRDLNNLFMYETTIPGGITENAFRPQLYVDISATLDIKTNALDCFDSQKMRCGHLWVDAIVGRCAYRGYQNNTRYAEAFEVIKVSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLL7</accession>
    <name>A0A6A8FLL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000472">
        <property type="protein sequence ID" value="MRN69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="104" mass="11580" checksum="F62EF9606AB1319E" modified="2020-06-17" version="1">MPQTNKRGLTRSFLVVNNLKGLRWDNSTSSMQHSVAPCYAEVRINSTLPTIISGQVFINIDNLSLECPNQYGLVLYARRILPENQAQSVIVPSYIMEQASPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLM4</accession>
    <name>A0A6A8FLM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000295">
        <property type="protein sequence ID" value="MRN69097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="168" mass="19267" checksum="A6C8BB486A46E094" modified="2020-06-17" version="1">MLKYFKFYYKSVIQGSTPFTIHPAAKIGYVHLRVSDIQQSLQFYHSLLGFKLVGRTSSSSESVFLSTGTDSKSPSFLIALSKIEATPKGKNDNRRSRKVAGLYHLAILLPERRFLANIFRHLQEHRDHVQFDGFADHAVSESIYLRDPDFNGVEIYRQTSFGMEMERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLP8</accession>
    <name>A0A6A8FLP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-phospho-L-lactate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_04645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000237">
        <property type="protein sequence ID" value="MRN68970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="307" mass="34193" checksum="C7B2DE55AE113124" modified="2020-06-17" version="1">MITVLAGGTGSIKLIRGLASQFSDITVVSNVADNIWLYGLYICPDIDTVIYGLAKILDLRQGWGIKNDSFECLRQMEMLGEQTWFKLGDKDLAMHLFRTNMLKSGKSLSYITERMRDKYAVSSIIIPATDDPVETKVLTDRGEMHIQEFWVKHRAQPPVVSIRYEGAERARINPKVIQAIRRSKLIVIAPANPISSIGPILAIRGFKKALVAEREKIVAVSPLIGNSAISGPAVKYMEAVKLNTSPFGVAKHYSEFVTKFVISKNDGDSSRRIVRLGMKVFETDILMKTSDDENRLASYLLTQVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLU9</accession>
    <name>A0A6A8FLU9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000260">
        <property type="protein sequence ID" value="MRN69020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="237"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="453" mass="49832" checksum="94033B8E88B4FEB1" modified="2020-06-17" version="1">MTSADNVPRLYIAFPIMVPEAKFDKGGSIIVTKTFKGVIVAAVNVNSIGKSLQSELSPEIISNVGLMDKNGVFLYARNHALIGKNYLGDEFQSSVPPEIKGSYDGILGRSLQGKAGAEDITVRGNTTTISYQPVTIDGKRLWTLYIGSPHSLTSNVGLLIDQQKNFSTLAVVAIGAIAVGMAFLILSWNRRLKGAVDARTLELRRANESLIESNKLLASANEQLKVHDRMQSEFINVAAHELRTPIMPILGDAEYIEHKFDITNEIVEVDKETIASIIRNAKRLDRLASDILDVTRIESKSLKLNKEQFDLSEVLSTCAQDLREQMEKDDSTRNVKISYPPRNILVEADKGRITQVILNLLRNAIKFTSEGVISINAFRKDDKIIVSVKDTGPGIDPEILPRLFSKFVTKSDKGTGLGLFISKSIIDAHRGTIWAENNADGKGCTFTFSIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLW2</accession>
    <name>A0A6A8FLW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_07355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000530">
        <property type="protein sequence ID" value="MRN69499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="277" mass="29711" checksum="BDE2BF4CC779649D" modified="2020-06-17" version="1" fragment="single">MVERRKQGREDEVSAFGLSPFRDSLYRALWIATLFSYIGAAMYDVGASWLMTSLAPNPLFVSLITTASTLPIFLFALPSGALSDIFDRRNILLITCGYMFTVSIILGMLTLLGVTTPSFLLILTFALGAGTTMIRTPIISTMSALVSRSEMPAALTLSAVASNIGRAVGPTVGGFIVAAIAPWAVFFLNSASFIAMIIVLSKLPRKSQAQTLLPPENIIGAIRAQIRYVRHSQAAHVLMVRAGLFTLCSSALLSLLPLLAKHELRLDSTGFGLLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLW7</accession>
    <name>A0A6A8FLW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000344">
        <property type="protein sequence ID" value="MRN69197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="206" mass="23828" checksum="F65B19A288B9FD6A" modified="2020-06-17" version="1">MFTPDTGSERASSVEDYQNTCSEFIVDISKDYKDWVDRYHLSEEETKSRKATIDNIVQTTNEWIYRYSDNIKKIDIVMNDGINKMAENTAGYPFNFQVSVNNMRRYTMHSLGKVKLNVRATPREARLARIGNYHKDQLLLISSSSPVNFNFSNESLKAADILDDYFVIDASQCQRRDLISVTIIVEEMDQDYASERRGYSTLILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM18</accession>
    <name>A0A6A8FM18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000372">
        <property type="protein sequence ID" value="MRN69247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="110" mass="12788" checksum="4E95FD08D001F2B4" modified="2020-06-17" version="1">MTEQISNNKKIIIVKVTKPDYLSGLTGAIYILKCLSDGLSKDQIIYDIFEGDRQLVFIWIEFLKNHHWLEENENSNTGDHGRVKITYEGSKLISEYSFEFENDLGNRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMB0</accession>
    <name>A0A6A8FMB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000335">
        <property type="protein sequence ID" value="MRN69180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="313" mass="33731" checksum="D29F96750D6C0921" modified="2020-06-17" version="1">MLPKRNKSGPSRTIKKREKAIAAHTDIDNGATGGKTRIKHLAKVVQGKKKLHSPILIAGFPGAGLVGSISTSYIIDKLHMNQIACVESEFIVPGVIYAEGKLRHPFRLYSNEKGDVCVLVCESPIMIQGMYSVLDTVMDWALRNKVKEVIVLDGIAVEGLPDSKRMPIILSSGGGEADEASLIHDNNINVTKKGEEKMADNSSTLYPTTAFVGGTSGGILSSCLSNGIASKAILIYAARGIPDPDGAATLIESLSRITDNESLKIDTHELREQGASLKMRMEKIIQSYVEQQQQGQQGQGQSPKSVREGIMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMB8</accession>
    <name>A0A6A8FMB8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_06620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000437">
        <property type="protein sequence ID" value="MRN69357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="30"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN69357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="221" mass="25284" checksum="2BE06BFF9BC4F03E" modified="2020-06-17" version="1" fragment="single">MSVKKNENLSDWYTQVIWKAGLADYAPVKGFIVLKPYGYAIWELIKDILDRKLKETGHQNGFLPVLIPEALLAKEKDHFTGFTPEVFWVTRAGNNDLSEKLALRPTSETIAYSSFSRWIASYRDLPIKMNFWNTALRAEIKATKPFIRNSEFLWQEGHTVHTDEEEAKGEVMLILDIYQRLIEDHLAIATIAGLKSEKEKFVGAQYTTTLEGMMPDGKALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMD3</accession>
    <name>A0A6A8FMD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000443">
        <property type="protein sequence ID" value="MRN69367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="229" mass="25845" checksum="45306D2342C4ED6A" modified="2020-06-17" version="1">MTEKTLVHLANGKVLGKKIVVFDNVEHIRVLSNPLAWQIMRLLSDTPMYPIEIAKKLKIYEQSAYYYVRKLVEIGALEEAGTSHVRGGTARLYHSSSPAFGIEMSGGERQLDFQTHANYEHQHARKFFNDYIVNNTFKGLIIVGAPDPHGPYRSSARDGHYAVHLAFFLGTISNIPSEFIVKLDADAKAEKVIEENNLISIGGPGTNIITAEFNKSLQRRKKYYCCCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMJ4</accession>
    <name>A0A6A8FMJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000382">
        <property type="protein sequence ID" value="MRN69270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="113" mass="13266" checksum="84FA8E94E34CDFC2" modified="2020-06-17" version="1">MDFHFSYVWVNSNLSKQFKQYAFTLQQYFNKSLQSKKNSSAFPDFKLIEATAKNNNFSLAGVPTYEIIWTYKHPTYGMRKLIEFGTAAHRSKGYFIDYPAYRKIFVVFANSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMW6</accession>
    <name>A0A6A8FMW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000577">
        <property type="protein sequence ID" value="MRN69557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="119" mass="13169" checksum="A86CAD19DA46E051" modified="2020-06-17" version="1" fragment="single">RSGKEIILGAKQDPIFGPLVMFGLGGIYVEVLRDVVFRLAPIDENEASRMVHSIKTINLLKGVRGEKPSDLGALVDSLQRLSQLVTEFPEIEEFDINPLLVLEEGKGVRTVDVRISLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNC2</accession>
    <name>A0A6A8FNC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded DNA exonuclease RecJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000531">
        <property type="protein sequence ID" value="MRN69500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="136" mass="14735" checksum="2DB971AF26C923A4" modified="2020-06-17" version="1" fragment="single">GMKYPHDIEGGFSIAESYARKVSDAIKKIEGSISKSDNIAYAQNNSALSASMIVNFVLGISEKPVALVYKLKDEIDSYIFSIRGNKSCKVHLGRVVNQISSEIGGSGGGHEKACGAVVPREKLKQFIYLLDRLVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FNM7</accession>
    <name>A0A6A8FNM7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_07660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000578">
        <property type="protein sequence ID" value="MRN69560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN69560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="170" mass="18902" checksum="C9AC55B538EBE083" modified="2020-06-17" version="1">MSAKVIFIGEAPGKNEDENGRPFVGVAGRILDGALQKAGIERSQVFITNIVKCRPPGNRIPEEDERSACRPYLDRQISLIAPRIICLLGATAYSSILGGKSIKENRGKIIKRNGQEYLITIHPAAAIYNKNLRHILEEDLSSLSKKIKKMENPKRNSLLDYIDGQNDRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFS0</accession>
    <name>A0A6A8FFS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000008">
        <property type="protein sequence ID" value="MRN68131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="53"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="423" mass="48363" checksum="E545CA896A7B50F8" modified="2020-06-17" version="1">MKFAGEITDPVHQYIRFTNVERELLDTAAFQRLRRIKQLSGAHLVYPSAQHSRFEHSLGTMHVAGFAGETLLAKGYLSKEESIQELRLAALLHDIGHGPFSHLFEEMLGAKCDLTHEDLGKKIILKTEISDILKKHGYNSNGICKLSFGESKIKFFNEIIAGALSADIMDYLPRDGLFTGAEYGKIDYHRLISSFEVVSNAHLAINRSALYSFESMLISRYEMFKAVYFHKTVRSAEVMLLHSMRLADEQLNLTDTSLDNYLNLTDDSTLEKIHSLNKSNEDAVRLVTDYRNRKLLKCVYEKFLHKHDDICRKMDRRALHNLASQIAEGARVQENSVFVDASRASSMPLTPTKKEISSILLVDKERAYETPISEIPLIDSVTGFLDMLRVYTTLKNREVVERSVKKVLGEEDSMYQKHRIRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFT3</accession>
    <name>A0A6A8FFT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_06130</name>
        <name evidence="3" type="ORF">FIO04_00980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000219">
        <property type="protein sequence ID" value="MRN61613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000029">
        <property type="protein sequence ID" value="MRN68255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="110" mass="11847" checksum="2980A146489C945F" modified="2020-06-17" version="1">MSNTIISVVIFVIGLIISTIIIYIVTRLFGDKKGIKTAFVAAIFGAIIYSIVGFILGNGFLAAIAGGIVWLLTLRALYDIGWLRAILIAIFIWIVATVVGVLLPTTPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFY8</accession>
    <name>A0A6A8FFY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000011">
        <property type="protein sequence ID" value="MRN68154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="181" mass="20510" checksum="1EA60E1082E28D3C" modified="2020-06-17" version="1">MEILQESKLAKYLFEKYSSNPKNWNFLISTSPLRDGFFDATVSNVDEVWQLKIDSIYKPVPIILGAKVDLDATKIERKMSNSSPAFGYRKLEPSLMMNILKKLTQEQQINANKEPDINNYINSVLGSLETVAPVSGGNYAYGPFVFTDRNPAGSNEYQKQVAEKLALKLRENLRNRYSGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG38</accession>
    <name>A0A6A8FG38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_01555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000050">
        <property type="protein sequence ID" value="MRN68365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="7"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="110"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="316" mass="34489" checksum="73B236D6ADE0B0C0" modified="2020-06-17" version="1">MHITGKVLVCDPIDNVGLSTLKKAGMTVDYCPQIETNELISRVKDYEVIVVRSRTKISREVIDAAINAKIIARVGVGLDNIDVDSAKVKGITVINASEAAINAVAELAIGNMIALARSITRADSELKKGNWIKKNLMGIELRGKYLGLIGVGNIGRNVGRIARGLRMNVIGYDTFPINQDYIKEVGLIKTDLNTLVESADFISCHVPLTSETRHMLNAELLAKMKPTTYVINTSRGEVIDENALYQALKANRIAGAALDVFEIEPPTNRLLMELSNVICTPHIGSQTKESQELASTVIAEKVIQIMYENQSDLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG77</accession>
    <name>A0A6A8FG77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000057">
        <property type="protein sequence ID" value="MRN68405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="133" mass="14461" checksum="B3E84B15F6C3FECE" modified="2020-06-17" version="1">MAKADATTTTATPDLCTISQDMILHIGFDDTDSTCGKCTTHLAFKITGHLLKNPDTKFLDYPLLVRLNPNIPLKTRGNGAVCLRVMARNHEKIIQDIRQLIEKESAIGMGANPGVAFLNGALVPEALKEFGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGE8</accession>
    <name>A0A6A8FGE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000038">
        <property type="protein sequence ID" value="MRN68304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="170" mass="19436" checksum="AF8F77259A06DA83" modified="2020-06-17" version="1">MIAAGVVATAIVAGVIGWSKRKSKEVRTEIDIRASDERVWQILTDFPNFVNWNPFITKISGDLKKHARLKVRIQPQGERGMTFRPIILDVEPKRELHWIGRLAVPGLFSGEHIFTIEPLGKDHVRFIHREIFTGLFVLIYARNFDTNIRQGFEDMNQALKAKAEQSISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGH5</accession>
    <name>A0A6A8FGH5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA protection during starvation protein</fullName>
            <ecNumber evidence="1">1.16.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO02_01125</name>
        <name evidence="5" type="ORF">FIO04_01390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:48712"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.-.-" evidence="1"/>
    <dbReference type="EMBL" id="WJXE01000008">
        <property type="protein sequence ID" value="MRN39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000044">
        <property type="protein sequence ID" value="MRN68334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01052">
        <property type="entry name" value="DPSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033921">
        <property type="entry name" value="DPSL_diiron-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="193" mass="21846" checksum="F96EC20A6DCC5E57" modified="2020-06-17" version="1">MTSNPKESVLKIVALEVLQKNGVNVERLKELITKGVGAEFATYYYYTILRMHCTGLEGEGVKEIVEDARIEDRNHFEAMVPRLYELGGSLPRDIRKFADQSGCPDAYLPDNWQDLSSILKVLLEAEQCAIRSWGEVCDMTAGKDPRTYDIAQGIMQEEIEHEAWFIELLSKRPSGHFRRKFVGQSPHSGTHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGI6</accession>
    <name>A0A6A8FGI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
            <ecNumber evidence="3">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mce</name>
        <name evidence="3" type="ORF">FIO04_02425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000090">
        <property type="protein sequence ID" value="MRN68535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="133" mass="14921" checksum="64D413404989A6FC" modified="2020-06-17" version="1">MRIDHIAIAVNNLDEAIGNYQRILKVDRLEVEIVHNEKVRVAMLELADTRIELMEPTSEDSPIKKFLVDRGEGIHHVAITADDIEKDISRATANGMKTLGGLRLGSYGRRITFIHPKSINGVLMEFCEAPTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGS4</accession>
    <name>A0A6A8FGS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000120">
        <property type="protein sequence ID" value="MRN68635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="134" mass="14980" checksum="17A4E05B8D48CCD4" modified="2020-06-17" version="1">MKKSPITTPVELKVEAAVNPSESPERVIASIANVIECSPEFRYGRRVIGRSLEIESLRTIYEQIRSRSAMGVLRRMLLNNRVADSTFFLLNKQAAATGIVVVIEEDQESPLGPIRVTLDCEELDALIDWLVPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGT1</accession>
    <name>A0A6A8FGT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000123">
        <property type="protein sequence ID" value="MRN68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="55" mass="6306" checksum="226FD79BEA6A588F" modified="2020-06-17" version="1">MVDQSMIKCSICKVISNGIEEFEKHLIGQHEMLDGNAKIVHYIAYLEQRITALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGU6</accession>
    <name>A0A6A8FGU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_02100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000072">
        <property type="protein sequence ID" value="MRN68471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="566" mass="60463" checksum="8445D2847B77AB9F" modified="2020-06-17" version="1" fragment="single">MASIQTTAGGMPVIILKEGTRENKGKDAQKNNISAAKLISEIVKTSLGPRGMDKMLVDTLGDVTITNDGATILKEIDVQHPAAKMMVEVSKSVDNEVGDGTTSSVIFAGALLEKAEDLISKDVHPSVIVDGYTAAAEQALKLLQKIAVKVDVDDKEVMIRIARTSMDSKLVSEDSPTLSQIVVNAIKQIAEDGGHDALKVDLDNIKVEKKAGGSMRDTKLIKGIVLDKEVVHSGMPKRVENAKIALITSALEIEKTEMSAEIRINDPQQMQMFLDEENRMLKSMVEKIKSAHANVVLCQKGIDDIAQHYLAKEGILGVRRVKESDMYKLSKATGARIVNNLDDLVTKDLGSAELVEERKVETDKWVFIEGCKNPKAVTILVRGGSQRVVDEADRSLHDALMVTKDVVEKPAIVAGGGAPEAYIASQLREWSSNLEGRAQLAVQKFADALDSIPLALAENAGMDPIDTMTELRAKQSKGAKWTGINVRGGVVADMYKLNVLEPLVVKEQIIKSATEAATMLLRIDDVIAASKSKMPAGPPGGGMGGMGGMGGTGGMGGMGGMGGMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGV9</accession>
    <name>A0A6A8FGV9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_02205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000079">
        <property type="protein sequence ID" value="MRN68491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="72"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="333"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="423" mass="47300" checksum="65529BB7B7E8A60F" modified="2020-06-17" version="1">MGVCVNIELYRSNKNLSDDLLDSIFEKAVSGKTLIKNRRTLTIDYVPEKLPFRDEETKTIAQTLSVVLKGARPSNLLLFGKPGTGKTAVIKNVVQRLHQKAKDLGIEVTVPFVNAKTANTGYKVLYEIAENMGINQEEEKKLQVHFTGLSMGEATDRILDFIQKKKKLHVVLIIDEVDSLVDRNGDDILYNFTRANEQISGGGFISLIGISNSLTFKDKLDPRVRSSLSEEEMVFNPYTVEQLQKILADRAKLAFNDDVISSAAINLCAAMAGRENGDARKAIDLLRVAAEIAERERLTNVEEKHVRLAQEKIEKDTNHEVLKNSTTHTKIVILAIMKSKNGNTGEVYDIYSSLCNNAEHEPLTQRRITQIISELDQLGLVSSDVVSKGRYGRSQRIKITVPTLTIREAFKDDPSLSTWDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGY3</accession>
    <name>A0A6A8FGY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000139">
        <property type="protein sequence ID" value="MRN68695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="86" mass="9106" checksum="92814F8B0C0A5CBE" modified="2020-06-17" version="1" fragment="single">MALESIELRRSTVSKSSKKTKSIIVIGVIGLTIIVAFGVATGISTGLTSSPMKLTNCTSKVLELAQKGMIREVAGYNGAIYECTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGY4</accession>
    <name>A0A6A8FGY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_02220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000080">
        <property type="protein sequence ID" value="MRN68494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="196" mass="21885" checksum="FB33932A888D1E03" modified="2020-06-17" version="1">MKIYTKTGDKGETGLIGGKRISKGDPRIVAYGSVDELNSNIGIAISSLTVKDRHLFLDLINIMTCIQSELFIVGSDLADPKYPGGNQNQYKTHRTEENMALALEDAIDKFETELEPITFFILPGGSIEASLLHITRTIARRAEIAVTLLSKDQIINPIVLVYLNRLSDFLFVAARLINKRLGIKDIAWRPSERQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH17</accession>
    <name>A0A6A8FH17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="210" mass="22449" checksum="55016448131596D9" modified="2020-06-17" version="1">MTERRQLDEIKGKKCNATKAVAIVLSVIELAAISATIISFQLAYAQNTIGANKELNNQTSVTASNASINLKLGNKAYPIKYQITGGKLAGISAEKDNTTLLVNVSSTSNGKLIIELPRNVVDSKKQGNVDDNFAVFEDGQYAVDDEIRTNAQSRTLMVGFDNGTSVIEITGTHIVPEFATVAVAVFAIATIGIIVASSKYIVLPVLFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH55</accession>
    <name>A0A6A8FH55_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_00230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="9">
        <location>
            <begin position="273"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="551" mass="61468" checksum="7127FE8F93688B98" modified="2020-06-17" version="1">MPVVAFTFDRLNKFFPGEKLDDILKIVPFIGVDIEGVDNAAVRIEYNPNRPDFASDYGIARAVKGLLGIETGIPEFKLSGRSGCAIKIDMSARQIRPYIVSLVAKNGKLDDETIKQLIAMQEDLQNVIGRRRLKASIGIHDLDAIKFPVTYTTVQEDFSFTPLGDSDNHTIRHILKEFDVGKQYGYILQKSNAYPIIQDAENNVLSFPPIVNSNLTRISTATKNLFVEVTANNLEVAEDVLSVMAMALYDAGFEIQTVSTHNSDGRNKETPKMDPSYIKVETSYINRILGLNLKVTDILKCLKKSRLDGKVMSGKIIKCTIPRYRTEIIDSTDLIEEVAVGYGIYNLRATIASSDLSGKRNYLSVCLDIVREVMAGLGMIEVVNFNLVSRKIHYQLMGIPEHDNILTAEKTKSIEHEILRESLIPSLIQTLSHNIHEEYPQKLFEVGKVFQRGDRINEYWNLGVVVAHSKANYTEGKSIVQTFLKTSFGKEIVTKSNVNAILVQGRSSDIIVDGQSVGYIGEIKPMVSDNFKLRVPVVAAELNLSQIMSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH75</accession>
    <name>A0A6A8FH75_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="7">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">leuS</name>
        <name evidence="10" type="ORF">FIO04_00330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="7"/>
    <dbReference type="EMBL" id="WJXC01000007">
        <property type="protein sequence ID" value="MRN68128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="30"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="734"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="653"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="1004" mass="115870" checksum="54FDE649C4E7ED81" modified="2020-06-17" version="1">MTSIDNKNNGDNKKNGERNRIDWKSVEEKWRDRWEEQRIFQADPDIGKKKYFITVAYPYPNSPQHIGHGRTYTLADVHARYMRMKGYNVLFPMGFHYTGTPILAMSRRVASRDKDLLETFDKVYHVPNDTITSFVEPVKIASYFHNEIRLGMKELGFSIDWRREFSTVDMIYSKFISWQFRTLRKKGLIVQGSHPVGWCPNDQNPVSQHDTIGDVEPAFNEYTLIKFRLGDGYIIPTATLRPETIYGATNLWVNPNIEYVKICLKDKDERWIVSKEAVKKLEFLNHKVTIESYVLGKELVGTLAKNPVTHVSLPLYPALFVEADNGTGFVMSVPAHAPYDYRALEDLKNNVSLQKEFGLRSVEVKPIAVIESDDYSGIDVIPSKQIINKFNIQDQTDTEIEKATNELYSHEFYKGKMLQNTGKYGGMPVSEAKDKVKSEILMSGDADIMFELINKPVRCRCGTRCVVKLLNDQWFLNYGDTKWKNLAHECVNNMEIVPEEIRQEFNYVLDWLRERACARKTGLGTKLPWDQDWIIESLSDSVIYMAYYILAKYVNDKSIIDVNNLKDSVFDYVLLGRGNIVEVASECNISTALLEQIRQEFTYFYPVDSRHSGRDLVPNHLSFFIFSHVAIFDRENWPKQIVVNGSVLMDGKKMSKSLGNIIPLRDAIKEHSADAIRLAMLISAELLQDADFSFDTVKGIRSKLQDIYDMGIESSTNSSQSQIKGAKINEELVDRWLLSRLQRTVADTTMSMDKLRVREAAHNIIYSLDHDLQWYEKRVKAKKRENSSVQYTLSTFLNARIRMLAPFAPFISEEVWEKIDNSSTSIIFAGWPSADEDKIDIVAEESEALIMNLIFDLQKIVKVTRITPKKIIFYTAARWKLKVYNKILSSVFLESNPNFGDIMKQLIKDPETTKAKNDSNMVRKMIEDILSDPIETRNRRLRFENFDEKLPIEDARNLLSLESGNEHAEILVYSEDDTDQSEYDPKQKAKFARPFKPAIYLIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH87</accession>
    <name>A0A6A8FH87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDC48 family AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_02330</name>
        <name evidence="6" type="ORF">FIO04_02815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000023">
        <property type="protein sequence ID" value="MRN39864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000113">
        <property type="protein sequence ID" value="MRN68611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="233"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="505"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN39864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="767" mass="84723" checksum="6049CFD1BB58125A" modified="2020-06-17" version="1">MSSDRDTNDKNTTRKETAKVANLKVAEVAEQRDVGRKIARIDPDIAERLNVSTGDALELSSLRKKSTVLSWPARESDRGKGLIRIDGFTRNRLDVGINDTIEVRKVESKDAKSITLAPTEPLRIVGAEEYLVDYLNGALMSKGDTIPINVMGQRIDLVVIATNPSGPVIINDSTKITVSEESAKAAQISKEGGVPSITYEDIGGVRNEVARVREMIELPLRHPELFKRLGVEAPKGVLLHGPPGTGKTLLAKAVANETNANFYTIGGPEIMSKYYGESEEKLRNIFEQAEKNAPSIIFIDEIDSIAPKREESGELERRIVSQLLAAMDGMSSRGKVVVIGATNRINAIDPALRRPGRFDREIEIGVPDRNGRLEILQIHTRGMPVAKDVNLEKLADISHGFVGADLQALSKEAAMRALRKVLPEIDLSSESIPGDTLKKIIVTMQDFTDVIKEMEPSAMREVFVEVPDVKWEDIGGLSSIKQELQEAVEWPLKYQGIFTHADATPPKGLLLYGPPGTGKTLMAKAAANESEANFISIKGPELLSKWVGESEKGVREIFRKARQAAPCIIFFDEIDSIAPVRGGDFGDSHVTERVISQLLTELDGLEILTNVIVIAATNRPDIIDPALLRPGRFDRLLYVAPPDRDSRIQIIKIHTKKKPLDEDVKIEDLAGHTDGYTGADIASLSSAAVMIALREHISKYQDPKEANKHVQELRIHLRHFEEAMKKIRPLSTQELNMYKRISEQFGRPDLAARWRSEKDTSDTAAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH98</accession>
    <name>A0A6A8FH98_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_03140</name>
        <name evidence="4" type="ORF">FIO04_00480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000035">
        <property type="protein sequence ID" value="MRN40024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN40024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="217" mass="25097" checksum="4D2D28A113D915E8" modified="2020-06-17" version="1">MTRLLDLGIDRIRNIIMDMAKLSEQSVFTSIDSYDKGTSVKKQIFEWSEKLRVLQDETADLAIELIARYQPVATDLRLIRSCMEIAYGFSRFGRYAYDIVEVLETIGHINDCDKTAVLGMASTVREMILLSVEALQLRDKNASAKLYEMDDTVDALYRKYLREVITPQNDQDKKDMNPRCYISALLILRYLERISDHACYISDSIHYIMTGRSSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHA0</accession>
    <name>A0A6A8FHA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000044">
        <property type="protein sequence ID" value="MRN68336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="200" mass="22932" checksum="D9F85E10EA818255" modified="2020-06-17" version="1">MAGTGKSVQGYICAPHERESGSLVDIWSNSLNILNIYFVTATFSNESMLYFPNRANHYILASYSNIDDISELICKQNPGRLSFMLSLSDALFEREATNLKYISMYFTKYVYGDPEIIDIANIIAKRERVKKLTLAHLQFLTTEQPKFTFPYSRNVVVLEVEGEKTHQSDQKYCERTRRDVARKGIPLNNLVSLSILDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHA2</accession>
    <name>A0A6A8FHA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000180">
        <property type="protein sequence ID" value="MRN68825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="64" mass="7227" checksum="9E16A13216B19596" modified="2020-06-17" version="1">MSNNVSIDFTESGPPHGTKAMPPAQKWQGGSVEKQEDLVLIGFRFKSGIIHYLLERRPHFFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHA9</accession>
    <name>A0A6A8FHA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2877 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000046">
        <property type="protein sequence ID" value="MRN68346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="369" mass="41548" checksum="34ECFD2D8D28A510" modified="2020-06-17" version="1">METQPETGQGIGRNTLKNLVRNKKYNTHMHQNRVSNRNQNQNQHFSHKEIGKYVFNCQWVGNLHARRILSERYGLYGDVISVFDTTLNVKTNNDDLLVVTISKVRSPINMNVLPIFKEKERGGGIQGFRGIIDFGTEVKIQKNEMSIGNVIFRLGKCRVFQSALDRLPSANHLSEFMSKSDEIFKILKTYSRKGCLLSPDLTTKGLLSKFLKNVHSYRCGYSNAFTATANTMMSQALLDLCGKGPGYTPSGDDFVAGYLGVFNWISRSLNFNTMNFPSEKFAPLTSWMSSKLIDYSKRNLCDEEIQAMINSIAAGDLNQYISSIVKISRRGHTSGIDIATGMTVALYTVIDDTFETNIIGRFFSSLYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHC0</accession>
    <name>A0A6A8FHC0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="3">DHBP synthase</shortName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribB</name>
        <name evidence="4" type="ORF">FIO04_02965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000122">
        <property type="protein sequence ID" value="MRN68641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="229" mass="25235" checksum="306F25F9C4EDEF3B" modified="2020-06-17" version="1">MDSVEGAITALRKGKFVLVHDEMGREDEIDMVIAAEQINPDHISTFRRIAGGLICLAVANEIAVKLGLVYMHEIIQDLSRVNPVFKKLTSGRSPYGDNPSFSISVNHRDTYTGITDIDRALTIMKMAEVCKKIDSTGVDEFSNNFRAPGHVPILIASKGLLYGRTGHTELCVYLMNIAGLVPAVAICEMLDSTTHRALSIKKAKKYASKNNIPLLESNQLKKNVYQDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHH6</accession>
    <name>A0A6A8FHH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_06755</name>
        <name evidence="3" type="ORF">FIO03_05890</name>
        <name evidence="4" type="ORF">FIO04_00890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
            <strain evidence="3">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000118">
        <property type="protein sequence ID" value="MRN40724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000206">
        <property type="protein sequence ID" value="MRN61567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN61567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="55" mass="6519" checksum="5F831F568813B087" modified="2020-06-17" version="1">MPEHGDYHAGSRRWYCNYWQSSKEWEDIHDYAPPDPSAETTDDPFSSRTAEKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHK6</accession>
    <name>A0A6A8FHK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000067">
        <property type="protein sequence ID" value="MRN68446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="709" mass="77556" checksum="95DCD547BBCA045C" modified="2020-06-17" version="1">MVKQAKRVQEIFDDIISKKNKVITEESAKEILTEYGIKVPTYALVKTESEAVEKAKQIGFPLVAKIVSPEILHKTDVKGVKVGLASEAEVRETFVDMHGRLSNQYETKGILLEKMVPPGIELIVGLQNDPQFGPVIMVGVGGINTEIFKDVSFRVLPITKEDAIEMINDLKGKQILKGFRGSEAVDMDMLGNAIANIGNLGTDMAAYYESIDFNPVIAYPHDYYVVDAKIILKEEPRSEAISKSQPDSSYMDVFFNAGSIALIGASPEQGKVGNSVFESLVKHEYKGKVFPVNAKGYPEIMGIKAYKSLEDIDEPVEVVVVTVDLRFVPDLLKSCGKKNIHNMVIISGGGKELGGERAAIEQQIKELSSQLKVRIIGPNCIGMFNGENRLDCAFQGHERMLRPQNGHVAFLSQSGTVGIAFMETADAFGMSKMISYGNRSDVDEADMIWYLSKDPQTKVIGLYVEGLGDGRKFMNTAKKVIHEAKKPVVVFKNGRTTRGAKQALSHTGSLGGSYAVVKGALDQAGIISVNSYEELTGSLKALIWQPVPNGSRVAMVTNGAGPVIAAIDHFEELGLVVAEISEPSKRAFKEHYPPTYVVGNPCDITGSASADDYRFAIQTFIDDQNVDIIMPWFVFQDDPLEETIIDVLAEFQKQKKKPILVGAMGGPFTQKISDQIEDHNVPVYHSVTSWVSAAGSLAKWSKVLTGTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHK9</accession>
    <name>A0A6A8FHK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000036">
        <property type="protein sequence ID" value="MRN68292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="82" mass="9501" checksum="58DB84D0F86293BB" modified="2020-06-17" version="1">MAIWTLMSTVSYHIYYKLSIFCGANNFTRKKFFMAMLAFEDDSHFERKAEIAILRFAKKGWPLIVGGETALCVDAYSFDVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHL4</accession>
    <name>A0A6A8FHL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000232">
        <property type="protein sequence ID" value="MRN68955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="343" mass="38327" checksum="0C4D715234D137BF" modified="2020-06-17" version="1" fragment="single">MLETRSHIVILGAGFGGLTAANMLRKGLSAEHHIVVIDKKDYFLMGVVNLWILGGNRRLEDSKVSLSNLKNKGIEFLQDDVIQIDFHKKIVRTKLSKQIEYDYLILGLGVDFAIEQINGFTENGGFNLYDATQVPKLREKILSIKNGNIAICITDIPYKCPPAPYEASLIIDDILTQSGIRDSINMDLYTPTQIALPVAGPKISQDVVNLLNRHNINFHPLHKLKRVINEKELEFGNGDRMDYDVLIGIPPHKIPVMVANSPGLLKEGENWINVGKFTLRTNYENVFAIGDVTEIKVNQYVAIPKAGIFAEAEAKVVSQQIIDEITNNDNESQNPRFDGKGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHL8</accession>
    <name>A0A6A8FHL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000033">
        <property type="protein sequence ID" value="MRN68278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="192" mass="21457" checksum="E83AB24530FDCEA5" modified="2020-06-17" version="1">MTRVVITGNPGVGKHTCAKFVSEKLGKAKLIDINRVILSNNAVTLRTSAVNGIGEIDVKKTEKLIIEEIKKTKDVVIVGHLAPYVLRTTGIDLVAVLRRSPYQLAKIFRQRKYTPMKMKENIAAEILGITLYDSVETFGKERVAELDTTGKTPQDIANDIVSKLQKSRKQIGIIDWLSLVYEKGDAQKFLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHN4</accession>
    <name>A0A6A8FHN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000158">
        <property type="protein sequence ID" value="MRN68751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="500"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="655" mass="70692" checksum="8BB9A3BB4D9FF81E" modified="2020-06-17" version="1" fragment="single">MSSSSSLTRDEKRVFLSPQSIAVIGASEKAGVGNAIFSNIVNGYKGKIYPINPSSSTVLGIKAYKSVLDVPEDIDLAVVATPNRIVPAVMEDIGKKKIKGAIIVTAGFKEADEQGARLEKDIESLAKSYGTRIIGPNCLGIMSLSESNIMNLTFLKITPKYGGIALLSQSGAICAATVEDAIEQGIGFSKVISMGNKVDMDENDILELLADDADTKVIVMYLEDIHDGRRFMEIAKRIIMENKKPIIVLKAGRTPEGAKAAISHTGALMGPDEIYDALFVQSRVIRVDTMQELFELSTAFSKQPTPSEQGGVVIVSNAGGPAIISTDACSKYGLKMADISSSREAIAKVIPPHGSARNPIDIVGDADFNRFEKVLVEVISNPSVGSIVTMCTPSATLDYDDLARIIVKTSKGSGKTMLAALMGLAEGTKNKEILSEGEIPHFMYAESAIQTLEGMYRFRDWLKKPAGRPKVFNADRKKVRTLFDNMRNSGRKNLVEEEGYEVLAAYGFTTPKTVLADSAERCVDASNSIGYPVVMKIASQDIIHKSDAGGVKVGLANDEQVRTAFNTILQNAKTYKPDANIKGVLVQEMVRSGKEIILGAKQDPIFGPLVMFGLGGIYVEVLRDVVFRLAPIDENEASRMVHSIKTLNLLKGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHP9</accession>
    <name>A0A6A8FHP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_03550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000160">
        <property type="protein sequence ID" value="MRN68754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="111" mass="12181" checksum="3F581DE9091112FD" modified="2020-06-17" version="1">MKMLLVLSKDFVKVADTKDIEPSQMKAVEVGDENICVINVEGKYYAIGNVCMHQGGPLADGTLEGYEVECPLHGAKFDIRTGEVTNPPASTPEPAYEVKVEDNNILIKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHX3</accession>
    <name>A0A6A8FHX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000185">
        <property type="protein sequence ID" value="MRN68841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="72" mass="8218" checksum="F3EE50B8D3CC4667" modified="2020-06-17" version="1">MSKDSASSDEHVIICSECGRELIVKDIVNNGVAFLSHLKIDHGITYTPQRMTEVKTERKRSTEKLIYKTDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI78</accession>
    <name>A0A6A8FI78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000235">
        <property type="protein sequence ID" value="MRN68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="186" mass="21563" checksum="A30B224C1E0F65D3" modified="2020-06-17" version="1">MSPSHRCDSLICDLVPLLIADRKIMDVGRTNAVLYLKHRYYLHDTPTSQSTRVKSNYQRKKTICILDDEVEVGLALKFILEENGFRVELFNNPLIALEIIKVCRYDLFLIDIIMPNMNGFQIFKEIMQINKKAKVCFITAFEEYAELFKDELSNLSISGFIHKPIEGDELIKRVNKMLSSKQNTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIB7</accession>
    <name>A0A6A8FIB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000035">
        <property type="protein sequence ID" value="MRN68289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="83" mass="8928" checksum="BC2DAC6B1D5B6C73" modified="2020-06-17" version="1">MPYTEDVGENRLSRRLAIFAFWFLGFGIGFLGYLSLPGIAQWFAMAIPNFLNQAVIGALIAGVVGSAVSTFSIVTWANRSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE1</accession>
    <name>A0A6A8FIE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_01640</name>
        <name evidence="2" type="ORF">FIO04_00815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000033">
        <property type="protein sequence ID" value="MRN60746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000023">
        <property type="protein sequence ID" value="MRN68223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN60746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="96" mass="10941" checksum="CB77522533DAFB56" modified="2020-06-17" version="1">MSSKEIIEIGLGSIGKIKIIRALSEAEKMATIYALHKRTNLKREDIKRNLSDLIKIGWVRETKLANAMYSANRENEYVNHLTSFFRAVGYIGQPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIL6</accession>
    <name>A0A6A8FIL6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO02_01025</name>
        <name evidence="10" type="ORF">FIO04_02950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="9">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="WJXE01000007">
        <property type="protein sequence ID" value="MRN39618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000121">
        <property type="protein sequence ID" value="MRN68638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN39618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="316" mass="36391" checksum="BA0E70C211BA25FA" modified="2020-06-17" version="1">MLPPALAANCYHLIQKCDKVIKKSAHGLNTLINLNRIYQEDCLSFMSKLKDQKILVDVIVTSPPYNMNKEYGIYKDNKEREKYLQWMKNVAEKSYDILKDDGSFFLNVGGRPVDPTSPFEVATQFRTIYELQNTIHWIKSVSIDAEDVGKNNEFREYGNISIGHFKPIVSDRYLSDLQEYIFHFTKTGNIKLDKLRIGVTYQDKTNIGRWKSAKQDKRDRGNVWLISYPTIQEGRPHPAVFPIKLPERCINLHGIKPNMLVYDPFMGIGNTALACLRLGLNYLGTEIDAEYIKVAQDKIASTPLETYLSEDNHEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIQ1</accession>
    <name>A0A6A8FIQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000126">
        <property type="protein sequence ID" value="MRN68652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="97" mass="10779" checksum="2F238A3C6C85753B" modified="2020-06-17" version="1">MVHFGINNPRTGKSMVYNKCIFCSDIYATNAKSTVCDKCVIVLTWVSGMNYLAAVNRVSALIKSNKLDSKLRNENYCKTNFGSRATQVIMDAIDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIR6</accession>
    <name>A0A6A8FIR6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">argS</name>
        <name evidence="11" type="ORF">FIO04_05625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000327">
        <property type="protein sequence ID" value="MRN69164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="421"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN69164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="536" mass="61092" checksum="3EA3ED0F0DFD1619" modified="2020-06-17" version="1">MTLNQALENPSYGFYNVGNGTHVVIEHTSVNPNKALHVGHLRNVILGDTIYRILKTTNHNVTVLNYVDDSGLQVADIVVAFKFAGFPLEPAEKSMKFDHYCGDHVYVKINELYKTDPGLEERRRLVLKELEHGTSELAQFASRIVSRVLHEQLMTCWKMKVHYDLLNFESQIVISKLWEKSFNWLKDKQIVHLASEGKNKGCWVLKGESKSADEKVIVRSDLTTTYIAKDIPYAAWKVGLVEDPFYYYKFSDQWDNTSLWATTLDSSKSSKGHPKFGSADRAITIIDSRQSRLQSIISGILSQFQLIENRYHHLAYEPVTLSSKTADLLGVDIGEKHSMHMSGRKGVYVNADYVIEMAQSKAYEEVRSRNPTFSEEQLCKVAEAISISAIRYNLVKYDLDKIINFDIVESLSLEGDTGPYVQYAYARSQRLLEKSTEEISQLSFCLLNKEPETMLIKAIAKLDLVVEEAARTLKPKSIARYVHMMATAFNLFYETVPVLKEPDRVKRVTRLALVVAFCRTLKNAFYLLGIEPLNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV4</accession>
    <name>A0A6A8FIV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_11560</name>
        <name evidence="3" type="ORF">FIO04_05710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000355">
        <property type="protein sequence ID" value="MRN41661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000336">
        <property type="protein sequence ID" value="MRN69181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="159" mass="18604" checksum="C84602F491A9F314" modified="2020-06-17" version="1">MSTTEGKGQQEQTIEIRKSIVIDSSPELVFKAITDPNELTNWFPDQAILEPKVGGKMKFSFYKNSKRGNQDHGRDKDYFHEGTITEFIPNKKISYTWEDSYEPDFPRTVVTWELEKIENNKTSLKLLHTGFKADEKAKQYDEGWSHFLNELVKYCEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV5</accession>
    <name>A0A6A8FIV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000148">
        <property type="protein sequence ID" value="MRN68722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="132" mass="14441" checksum="7340ECCB2C1074B4" modified="2020-06-17" version="1">MIGKQSLGISDEHSWKMFRGSSMRTGASASNIPRKPSLLWLTEVGPSVSSPIFGDGTIYVSTITGRIFALNPYEKQIKWHLNVGSPLVSSPLLHNSILVAATYDSWIKDASFTGKNFVLGMNIDDGKQIWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW9</accession>
    <name>A0A6A8FIW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_06410</name>
        <name evidence="2" type="ORF">FIO03_02910</name>
        <name evidence="3" type="ORF">FIO04_00375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000107">
        <property type="protein sequence ID" value="MRN40659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000073">
        <property type="protein sequence ID" value="MRN60995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="106" mass="12201" checksum="64278C733144B737" modified="2020-06-17" version="1">METKLVIKTILDNEDSLSTRSPVRVEILSSAENTPLLDKDLHEILRDASNCCEFTSYVDRNGETLVKIECEVSEDEKERVWDLLRFKHKRDCTLSAEPANSMNNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX7</accession>
    <name>A0A6A8FIX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000155">
        <property type="protein sequence ID" value="MRN68742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="93" mass="11039" checksum="475E6CAAA221D34E" modified="2020-06-17" version="1" fragment="single">PKDNQIEVIYHLGSYLRDDLAGHVLSIATRTNRDDARLPTLINVYKSVEYHERETFEMLGVYFEGHPRNERFLLPEDWADIPPLRKEFRIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIY0</accession>
    <name>A0A6A8FIY0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000346">
        <property type="protein sequence ID" value="MRN69201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="113"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="326" mass="36588" checksum="D28389190C4DA8F3" modified="2020-06-17" version="1">MPTHKSTEQMVQNIREQQSNIDVRYIEQTSGTQATFLVIDRKASLVMEIKDDLKTTFDDAIGLSTYSNSKAGVLSYISIFENLWKQTELYEDIKKAHEQLKNHDRMQKEFINIAAHELRTPIQPILGLSELLISKTGNIQQYKESLDTISRNAKRLSRLTDDILDATKIESKSLLLKKELFNLNDVILNALDDIILSRDFNSENVRLLYHPQDILLEADKGRITQVISNLLSNAVKFTEKGTINIMTKIDEDRDLIVIGVKDTGTGIDPEILPKLFSKFAAKSFSGTGLGLFISKSIVEAHGGEIWAENNAGGEGTTFTFNLPIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ11</accession>
    <name>A0A6A8FJ11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_03770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000172">
        <property type="protein sequence ID" value="MRN68798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="276" mass="29291" checksum="05B52F1CC240245C" modified="2020-06-17" version="1">MQRALLSGVVVAVTCSVVGLFLVLRRQSLFGDALSHAAFGGIAVGLFTNTYPIWTALLVSVLASLGVTKLRQSTKIPPDAAVAVMLSSGLAMGIVLIGLAGGFNLDLESFLFGSILLISMQDQLMILMLSTVVLLIIFKLYKQLMYITFNEDQARVSGINVTRLNYLFIGLASLAVISSLRLVGVLLISSLIVIPNITAMMFGKGFKKTAMISIIIAVSSVLGGIVTSYFMNLAPGGTIVILSIAILLGSIGTKSLLQKIKIRNLANEPQSLPKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ38</accession>
    <name>A0A6A8FJ38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000391">
        <property type="protein sequence ID" value="MRN69284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="348" mass="37321" checksum="E75E38107C255108" modified="2020-06-17" version="1">MMNSNFTTGSSLYRIMAVEPRIFPTLTVVLAISILSILAVVISPNVYATSNNSDNSVKMTKQGSFINSDGNLNIVGAIDNNGNVPVEVTVGLNTTSNNGSSHNIKTMTEQTYGTIIYPSTGGAPFKFLIPSNTLAVGEAFIAAVKEVQVPYYNVVVLTYNNTATGIDRALVGIAKNTGSFDIHDVVIYASAHDSNGAWIDSVKSNIIPIIKPGEQIAFSAKPDASVKSKVSYFSCAGLAFLEPITTLKVSDTRYIAYDLEGAAKISDLRYDNSTNSIMFGITHYNPAGGSMTLKVPQYSKSQAISIMMDGKLYKEATVQMNGKTISLDFFVPPGDHQMQIRVGSVYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ51</accession>
    <name>A0A6A8FJ51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000082">
        <property type="protein sequence ID" value="MRN68503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="84" mass="9726" checksum="6DFB3CB0903D0A18" modified="2020-06-17" version="1">MSTILKTVIIGLITSDSYERCTTFSRLRRFGSIRSPTMKPFAFEFGKHLQQRSGHDSSHDMNLMLSLYEDIKSRLIRVHGYSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ57</accession>
    <name>A0A6A8FJ57_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000382">
        <property type="protein sequence ID" value="MRN69271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="73" mass="8597" checksum="D6C9F19A2373C666" modified="2020-06-17" version="1" fragment="single">MFRYGIELFLETTLFLVFVLEVYSSEKPVRVEYQPTVKGLALQPIMDMMAAYSMKYCSKDVFKDAKPREFQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ63</accession>
    <name>A0A6A8FJ63_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">rADc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_02315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000083">
        <property type="protein sequence ID" value="MRN68513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="5">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="1"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="228" mass="25752" checksum="3BDF5C212F899455" modified="2020-06-17" version="1" fragment="single">LKDGRVLEKLIEVAGISQNETVYEAGTGEGNLTTELCKRAKSVVSFEVDHDLFKKSSRLISAFPNLKLINADVFKFPVCVFDVFISNLPYSRSRDALQWLALQKFTRAILTVQKEFADKLQARPGDENYRSITVITQHCFIIEQLFHVSKGSFDPHPSVESTVIRLVSKEPGIPITRATIKNLNLLFSSRNRKLFSVLKKHNCKIDFAGTKRIDELQPTQLLSLAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ65</accession>
    <name>A0A6A8FJ65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000028">
        <property type="protein sequence ID" value="MRN68247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="66" mass="7418" checksum="186B68F89964A377" modified="2020-06-17" version="1" fragment="single">VDGVISGFKMIKEEKKPIYISVGHKINLINAIRIIKQLVKPEERIPEPLRIADINSQALTNSVLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ85</accession>
    <name>A0A6A8FJ85_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000200">
        <property type="protein sequence ID" value="MRN68878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="32"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="187" mass="20597" checksum="A37623576D726CEE" modified="2020-06-17" version="1">MVNTLYELEVFHKKVHQEELVRNKLPHSKGKFSKILVGIDGSQPSMDAAEYALAMAKKDNAELIAIHVLSAKSGYEHTPQPLLFGLPATPSSVNDIIQTSKEEAQRWLDKVKEQQLDDENIEVKLKTEVILASTSIIAAELVDYAQEENVDLIVVGTKGRSGFKRLLLGSTASGVVTYAHCPVMIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB4</accession>
    <name>A0A6A8FJB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000253">
        <property type="protein sequence ID" value="MRN69006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="83" mass="9853" checksum="B9BFEF604196C477" modified="2020-06-17" version="1">MDAYLEEELYDLLIYCLQNPQGPDFGAKKKRAEEIGSELYADGGLDAMENMFYSIEFRIKEEIDKDAKPYRAWWNNISGEWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD9</accession>
    <name>A0A6A8FJD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal proteasome endopeptidase complex subunit alpha</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psmA</name>
        <name evidence="4" type="ORF">FIO04_06585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000432">
        <property type="protein sequence ID" value="MRN69351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="3">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="245" mass="26533" checksum="C19B9E8DB0079410" modified="2020-06-17" version="1">MLPAAAGYDRAITVFSPDGRLYQVEYAIETVRRGTLAIGIKSKEGVLLAVEEKARKLQISNVTQKIFQVDDHIGVAAAGYIPDARTQVDHARFFAQSNRLIYDEPVDVEGVAKNIADMAQQFTQYAGVRPFGVALILAGVDKSGAALYLTDPSGTYIGYDAVAIGAGSDQVTEFLEKSYKDNMSMEEGGALAMESISLVSEEKTGTRHVKMAIIANDSRTMRKVEEEEIEKYAAMAKGKPANRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJF6</accession>
    <name>A0A6A8FJF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000044">
        <property type="protein sequence ID" value="MRN68337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="314" mass="35172" checksum="5D1C203C9CDD4224" modified="2020-06-17" version="1">MLKVTVGIPSFNEEKNILNLLQSVIKQKSEHFAICEIIISDDSSDDTIRLIEEFATNNSEAAIRCLHHSSRMGVANAWNEIFQNAKGDVIVMYDGDVIPHEDSIREMLGALDGRVVLSISNSEPTRSVSVAGRAATCVSSWLRSVRNKRLSQYTAIGRGLSIRTNIAKKIAIPSDIIAVDLYLECKVLEFKSDVAYTDRSVVYFCPPGTIADFNSQVLRSLKGHKQIRHCIEKFNIRLPLDVALRQTVRVFLSDPLGALAVAACYSLLPYHKHRLKGLDSSKWHIAQSTKSTRNFSINNPPSYTDMRPDRRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH3</accession>
    <name>A0A6A8FJH3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 1A</fullName>
            <shortName evidence="1">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eif1a</name>
        <name evidence="4" type="ORF">FIO02_03880</name>
        <name evidence="5" type="ORF">FIO04_02875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000049">
        <property type="protein sequence ID" value="MRN40164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000117">
        <property type="protein sequence ID" value="MRN68623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN40164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="88" mass="10204" checksum="299AC709D0ABEA9C" modified="2020-06-17" version="1">MVRPQQGELLGRVIKLVGGDNIIVRCTDGKVRTCRIRGKIKRRMWIRDNDLVLIAPWDFQAEKADIVWRYIAAHAEKLEQDGYLEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH5</accession>
    <name>A0A6A8FJH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2255 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_03990</name>
        <name evidence="2" type="ORF">FIO04_04635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000114">
        <property type="protein sequence ID" value="MRN61202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000236">
        <property type="protein sequence ID" value="MRN68968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="121" mass="14039" checksum="55C2B1C78A28EE42" modified="2020-06-17" version="1">MSKSKLYAALDRLSEIELTVMARKSGREISRPVWFVREDNILYLLPLQGSDTNWYKNMQKNPNLKISVDGQEIITGNGKAITDQKKVKEVIEKFKSKYGDSDVKKYYTKFDVCVELDLKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJJ1</accession>
    <name>A0A6A8FJJ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps27e</name>
        <name evidence="4" type="ORF">FIO02_00800</name>
        <name evidence="5" type="ORF">FIO03_02205</name>
        <name evidence="6" type="ORF">FIO04_01615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000006">
        <property type="protein sequence ID" value="MRN39573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000050">
        <property type="protein sequence ID" value="MRN60856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000052">
        <property type="protein sequence ID" value="MRN68377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN39573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN60856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="65" mass="7105" checksum="551FC23C04FFA81D" modified="2020-06-17" version="1">MSKRNIMIPKPNSNFISVQCTECGEKRIIFTHTTTDINCKSCGQPLAKKAGAKANILGKVLNILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJK3</accession>
    <name>A0A6A8FJK3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FIO04_06900</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000474">
        <property type="protein sequence ID" value="MRN69411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MRN69411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="395" mass="43617" checksum="E77A0B17C4BDE6F7" modified="2020-06-17" version="1" fragment="single">MLEGGKTILRMGRFELRMRHLLVIGVLSLAFTTAFIMRSYPSKYGFYLNEFDPYFDYRATKYIVDHGLNAYFNWHDTMSWYPEGRNVPATSQSGLHIVAAFLYKIFGAGTSLLDFTILLPVVLGSLTTIVVFALVRTLGGTTAGMFSALLFAFSPAIIQRGNLGWFKSEPLGLFFGLLGVYLLLSALKHKEVKYAILKAIAGGFVLGLANASWGGVQYFSIPISIFFIALPFFRKDTTIPVYVAIAFTVITILTAGAFPRPGISFVFGLAGLALMGGTTFLIMAHFVKKLSEPRKAIRNTLFLLIAFFALGVGFIAVGAYHHSSFRYLNAVNPFLSTQNQLVASVAEHFTPTLVDYFTNYSILLMFAGLGAWIAFKRRNDMSVFALILGLTGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ3</accession>
    <name>A0A6A8FJQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000274">
        <property type="protein sequence ID" value="MRN69048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="75" mass="8967" checksum="8961FE36C8DB34D2" modified="2020-06-17" version="1">MGLNKMLFFLSKHKIFTLYTNYRFPTESWINTWLSAAPDYFPFSIKVNRYITDHTRLKVEKALQLCTNLVKRFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ4</accession>
    <name>A0A6A8FJQ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDPG_MGDP_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000068">
        <property type="protein sequence ID" value="MRN68447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh" evidence="2">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="157" mass="17798" checksum="D776B737F05C362D" modified="2020-06-17" version="1" fragment="single">FYSGGVDNVHDDGRSNSSSSSLKSLGIPMHPVSNMEVAETTKNAENAHRYLQIAFAEDLYLYCQTNNMNFPQLRDALNTKWNVNILEPREGLGGHCLPKDTKMFLQSTSRRKRKILRAAMEVDEDYKRFRAKLGKRSNPSLLKMMELEIPIASDCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR2</accession>
    <name>A0A6A8FJR2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">aroC</name>
        <name evidence="10" type="ORF">FIO02_01370</name>
        <name evidence="11" type="ORF">FIO04_01060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
            <strain evidence="10">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="WJXE01000011">
        <property type="protein sequence ID" value="MRN39685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000032">
        <property type="protein sequence ID" value="MRN68270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="302"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN39685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="366" mass="39293" checksum="477B74E5563D95C2" modified="2020-06-17" version="1">MPGNILGERFVTMSFGESHGKCVGMVVDGCPAGLPLHESDIQSQLDRRRPGTSVITTQRKEEDKVEIISGMYNGFTSGAPICMLIWNQDQDSGPYELIKTKPRPGHADYQAMVKYGGFADYRGGGRFSGRLTATLVMAGSVAQKLLQYSLGIETIAYTKEIGGITAESIDLMEAKKNRYTNDVRCPDIAKAEKMKAAIMEARRDGDSLGGIIECISTGLPVGLGEPIFASLESDLSKALFSVPAVKAVEFGSGFNGTKRRGSENNDRYIKQEGRIITTTNNSGGILGGLSSGMPLVIRIGFKPASSIAKTQRTVDLLTGAQIDLNVPGRHDPCVVPRAPPIIECVVSMVLTDHALRGGFIPPVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR8</accession>
    <name>A0A6A8FJR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000275">
        <property type="protein sequence ID" value="MRN69052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="57" mass="6303" checksum="CB0C0151339A3079" modified="2020-06-17" version="1" fragment="single">MSEAGVKTVYLIVHGQKQLLEQVIEKLVARGFKRSNMQAASLEKAGNKGDFVAMVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS0</accession>
    <name>A0A6A8FJS0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl23</name>
        <name evidence="5" type="ORF">FIO04_07205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000511">
        <property type="protein sequence ID" value="MRN69471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="88" mass="9812" checksum="9AC7BF2B47557ACC" modified="2020-06-17" version="1">MSAEEARRIIIKPYITEKAFNLIEGQNMIIFIVDHQATKKHIKAALKSLYEIEAQDVNTLRSIRGKKAIVKFATAEGARDLATSLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS1</accession>
    <name>A0A6A8FJS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000071">
        <property type="protein sequence ID" value="MRN68467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="83" mass="9577" checksum="4B7CE77063D6F4A0" modified="2020-06-17" version="1" fragment="single">RRSLVHVMDIMIQKSHLIIMHTDRTAEDGLKYMSRKRMDTVFICDQEGKLTGLVSKTDIMNAAGKRKDYAEGIGKLSRHKSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJY6</accession>
    <name>A0A6A8FJY6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000315">
        <property type="protein sequence ID" value="MRN69138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="326" mass="36067" checksum="4278093B175752F0" modified="2020-06-17" version="1" fragment="single">TQLIMGFVDNAVNRLLRLDDNQEAAVVLAPIDNKSSVDSVPTVKESEDLAIPQTLPTLRGELNYPEIWKLHKASYLHNKEEVKNWITAATAFKQTPTNKAAEVVHRKALIFETSIINEPSLAETILLRGSSRKFSRQPISFTQLSNILHYSTRGVPLDFLDSKSDNDNNKNSTIDIYLIVNDVEGLQAGAYFFDRYNESLEQLKNQVSREISGYLCLGQSLFSDANVVFFLMTDLNKILDTLGNRGYRASQFEAGVIAGKIYLTAYAQKVGASGSTFFDDAVSEFFSPHAADKSTMIAVGIGVPGYKSRPGKNLAGQLSRTEILTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK01</accession>
    <name>A0A6A8FK01_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lig</name>
        <name evidence="16" type="ORF">FIO04_04075</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="WJXC01000193">
        <property type="protein sequence ID" value="MRN68859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="331"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MRN68859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="594" mass="67267" checksum="E8824B42FA4979FC" modified="2020-06-17" version="1">MDFSIIVDTFEQMERTSSRLALTDYLVSLLRKTPADIIDRVIYLIQGKLRPDYEGVELGLAEKMAIRAISLCTGLDVESIEQIYRKTGDLGDTAGEVMKSKNQTTLLAEKMTVERVYLTLDKIAHSGGTGSQDAKLRLVSSLLSDATPRESRYIMKFIMGTLRLGIADYTVIDALALAFTGDKSYRQILENAYNVSSDLGTVAKLLAIKGLESLRLLEITLYKPVRPMLAERVRSAEEAMVRMKGQSLAAEYKLDGERIQVHKGKEKVELFSRRLEKITHHYPDVAEAIQKLIKTNETILEAEVVAINAQTDEFLPFQELMHRRRKYGIKEAIEEYPVVINIFDVLYIDGEDKTSLPYLQRRKLIEKATKGLKNEKVRLVPQAIVKKTEDLEKLMAVAIEHGCEGLMIKQLTSSYRAGARGFAWIKLKREYRSDLADTLDLVIVGALYGRGRRVGKYGALLLAAYDSKADMFRSTCKVGTGFTDLHLEHFYKNLEDTRITHRHPRVDTGMQLDLWFEPKIVIEVSASEITLSPSHTAGINSIRENYGLALRFPKFTGKIRVDKNPEDATEVEELISMYKRQMRSIKNTRALPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK03</accession>
    <name>A0A6A8FK03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease subunit gamma</fullName>
            <ecNumber evidence="4">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_02405</name>
        <name evidence="4" type="ORF">FIO04_03845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4"/>
    <dbReference type="EMBL" id="WJXE01000024">
        <property type="protein sequence ID" value="MRN39879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000177">
        <property type="protein sequence ID" value="MRN68813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN39879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="100" mass="11160" checksum="1DEB0E512EA74C06" modified="2020-06-17" version="1">MMLTPREIDKMMIWTAAKIAEDRKKRGIKLNYPESVAYIANHVVEGAREGKTVAGLMKSAREILKKADVMPGIQDMIHTVQVEATFPDGTKLVTVHDPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK11</accession>
    <name>A0A6A8FK11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000052">
        <property type="protein sequence ID" value="MRN68380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="141" mass="15620" checksum="2FD8F362D4A6070F" modified="2020-06-17" version="1">MLSCCSWSKFGRDGEFVVAIYLNSCGWNVQLSRGSRGPADIIATRRSTKWLIQVKSSRKIPSLKGQELNRLREMAKSADGLPIVATVQPKETAIAVSTEEARGVDSNEYSIQIGNDAGRRSESTAYGIFLYSLVDWKIVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK14</accession>
    <name>A0A6A8FK14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000376">
        <property type="protein sequence ID" value="MRN69256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="222" mass="23842" checksum="EAC0EEBDC6323BA2" modified="2020-06-17" version="1">MLKHQIKIIKEGSGLNKQLSSSLSSRVAVVTGPTRGIGLAISKEFAENNDAEVVICSGSKQRALQVAKEISGKAFGAKLGITDISDVLEEIIGVRHRIDILVNNARYHFNSKTWSKIRSELQSISEVLHGSMRTCRNVISTIIGADGRTTQNAIGGRGVIIASTPDISAHTQGSPYTFAKAAIIAMIKHNACVHGRNTTEAFIGLRNIAKEGAYNSMSTDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK48</accession>
    <name>A0A6A8FK48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000393">
        <property type="protein sequence ID" value="MRN69286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="274" mass="30369" checksum="00538D3878278A90" modified="2020-06-17" version="1" fragment="single">MSPIMNVKVLVTAVGGIVAQGIIKSLKLANLSDNAVVKYRITAGDMSAQAAGLYRCDNGILLPSATSTDYIESILKIARDEDMDAIYIGSDEELLIIGNSKKRIESESKAKVLSSPIDVLTTARDKWKTFLFLKENNLPVAESALPADDEKFVKEFGYPIVVKPREGYGSLYFYLVRCKSEMQQAISNIQKAGWHALLQEYLNENNTEYTSGVTIDRFGKYVMSSVSIQKTLKNGQTYKAFIDDYKEVRRSSEEAALKLGARGAINIQAKLIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK50</accession>
    <name>A0A6A8FK50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000105">
        <property type="protein sequence ID" value="MRN68587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="363" mass="39821" checksum="C9C5CF023DA108C5" modified="2020-06-17" version="1" fragment="single">RIEVYGARALVNGIEKIHLCSNDYLGLSRNPLVLKEARFSLRHMSQCSSRLVAGNAPKLLELEEQIAKHRDTESSLLYPNGYMANLGVITSIANKSTTIISDELNHASIIDACRLSRAIIKVFRHNDLEDLEILLRSTAGDKIVITEGVFSMDGDFSALDKICCLAKEYNAVMIVDDAHGDFIFGSPGSYSGVPGYFDVKGMIDVNVSSLSKGLGCFGGYVASSKLVRELLINKSRQFIYTSALPEHLSAAALAAIPFAKKGNLQHRLFRNVEFFYKKLTDLGFSINNSASQIIPVMIGDEKLAIDFSNELLLDGVFVQPIRYPTVGKGKARLRLTVTSLHTKGDLLTAADSFEIIGKKNNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK63</accession>
    <name>A0A6A8FK63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence damage-inducible protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000356">
        <property type="protein sequence ID" value="MRN69218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="61" mass="6688" checksum="7C2624AF9327264D" modified="2020-06-17" version="1" fragment="single">MRTFTSEILCVGDELLSGITINTNAYWISQKITEAGGSVRRITAIRDDVNEISLGVRDSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK69</accession>
    <name>A0A6A8FK69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000360">
        <property type="protein sequence ID" value="MRN69228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="229" mass="25958" checksum="EB328427EE4CC95E" modified="2020-06-17" version="1">MTYYVAKQTELSSYLPTIQKMIDSFEINIGITNSIGNSFLTYENNSTLGIKIQYPANWQRIESEDDAHGVLFLSPSESNSDRFLESFSVSSNILFNSNNNSVNELARRAISEHIEHLPDFQLVNTKLITVKDNPAYLLVYKYTDLVFGKAMAMDIGMTNGDKVYVLSYLAEPAKFLFYLPTIQKMIDSFEIPNIVNRFVERSVAPAVSLCSDNLEAIINLDCLSIMFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK71</accession>
    <name>A0A6A8FK71_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupredoxin_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000404">
        <property type="protein sequence ID" value="MRN69306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="167" mass="16993" checksum="106944D280A20B68" modified="2020-06-17" version="1">MWVGRTAMITLFILGAITAVVVYTIFHDVAPVPGVMSSLYRKNLTPQDIAAANPSSGGSGSTGASTGPVGASVTILAGASTQGNPAYAPDTVTVKKGDAVGVINKDSVPHTITNGKDPSDPTSGKLFDTSIISPAASAQFATTKLAAGNYPFHCSIHPYMTGTLKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK95</accession>
    <name>A0A6A8FK95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-disulfide reductase</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxB</name>
        <name evidence="4" type="ORF">FIO04_04540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000230">
        <property type="protein sequence ID" value="MRN68949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="336" mass="36398" checksum="EFB2C26B62C6CAE4" modified="2020-06-17" version="1">MSKTDGKDESVNSGKVSLYDVIIVGSGPAGYTAGIYTSRARLKTLLVTGTLPGGQLMTTSEVENYPGFPNGIFGPELMMNMRQQAERFGTIAVDDEVIQVDFKQRPFKITTSSEVFESKAVIICTGASPRKLGIKGEQTFAGRGVSYCATCDGPFFKGEDIVVVGGGDTALEEATFLSKFGKSIKIVHRRDSLRASKILQDKAFENPKIEFLWNSVVSDIIGDKKIASIVVRDVYNGKEQKIHAGGLFVAIGHDPNTGIFTGQLELDDKGYIALKNNSLTSVEGVFAAGDVHDYRYRQAITAGGFGCMAALDVEKWLTERKHSENKAISSSFYSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC0</accession>
    <name>A0A6A8FKC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FIO04_06070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000374">
        <property type="protein sequence ID" value="MRN69252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MRN69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="528" mass="57149" checksum="63740012AABE5C5F" modified="2020-06-17" version="1" fragment="single">PKEFASQTPIFYYEVAVILIITVWFATFSEALSEAQAKARVDSLRSLEKEVSARKIVGEGKKEVIVTSTSLKPGDEVLVYVGEIIPRDGLVCEGKAFVDESMMTGESNPVFKDKDDHVIGGTRIASDKLRIEITAEVGRSFLDEMVSLIESATRPKTKNEIALTILLAGLSLIFLMVVGSLLFFANFLGYIADIAMLIALLVALMPTTIGGLLSAIGVAGITRIGRDNIVAKSGKGIEAAGDCDILILDKTGTITEGSRSANEFVPLQKYTERDVGQAAFAASIHDTTHEGKSIVHLAEEKRFIPPLIEKILTARKIEFSAETRFSGLEFMPNKRIALDTELQEEATSIHKFEDGNGEEAPRTNGPSRVSSMLSELEQRNEEVKILKGSVDAMLKFLTHVNEAELKWKAQEISKNGETPLLIAINSEGIGLVALKDNLKENIRQKLDEVHATGITTVMLTGDNQLTAQVIGKEANVDQVMAEAKPTDKLVRVEEEQSKGHVIGMVGDGTNDAPALAKANVGLAMNSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC5</accession>
    <name>A0A6A8FKC5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin kinase</fullName>
            <ecNumber evidence="6">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FIO04_02250</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000081">
        <property type="protein sequence ID" value="MRN68500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP-dep_RFKase" evidence="18">
        <location>
            <begin position="102"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MRN68500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="228" mass="25763" checksum="B0EC993DF3236124" modified="2020-06-17" version="1">MSEIKLQHILTMTELLLLGAKYSFVELTTTDLGKNIMKSQQAASKHLQELDAAGYIDRVRRGQKFRVKLTDKGYSAIEKLFSTLKTAMESTPPTTISFEGRVVSGMGEGAYYMSLGGYRKQFYEKLGYEPYPGTLNVKLVDKIFRDSRREIGKYPSIFIDGFSDTKRTYGWAKCYLAHINDGPIRNAAVLVLERTHYDESMLEIIAPVSIKDTVGIHNGDKIKIKMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC8</accession>
    <name>A0A6A8FKC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000378">
        <property type="protein sequence ID" value="MRN69262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="111" mass="12684" checksum="2D6D7A85C80D8155" modified="2020-06-17" version="1">MLHSPLGFKNSFLIYKVTTMSESQEIREIKRVYADIIPHFFSKIRGMVPAIYENGTHFVTNQKLTLEMLREISDSNDVLEVAGEYTGNITARGSSHVHSDDCPLRNLDYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKE1</accession>
    <name>A0A6A8FKE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000251">
        <property type="protein sequence ID" value="MRN68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="PTHR16779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="420" mass="47856" checksum="F0A9B5E6F48D28C1" modified="2020-06-17" version="1" fragment="single">MLLDDILVGIITVVWLTNVPIAFVSIIRFLKNREAFIGKDVQRIHNDPVIIFQITSRSATKTPVVLRGIDSIVTSCDKIKYIDYRISVITDDPQDIDTLSHSNSEVVLVDKSFSSSAIKKGRALQYAVESRRKTGRNTSKYWIFHMDDESYVTNQTVLSLLKAIREGQGLAFEGPIFYPLKFESANILTALAESIRPFTCYDCVSQMKNEQYVKTSPLHMHGSNLLVRSDVEDSIGWNFGPTLAEDQMFGYQVYHKYGPRSMGWHGGILLEQPPLNRRRWVLGSLQNIDKFPLIHRFKLSYKLITYFMGFASGFISLILSFHINLPLLLMTSNTLINYRVGADGMAVFGNLLRTLYSELTVHFFGNMGAFQFGIGAILLFSSMIWLLSYQIGLFLNLRYSKITWSKRFVLHLQTLILCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKE9</accession>
    <name>A0A6A8FKE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000405">
        <property type="protein sequence ID" value="MRN69308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="71" mass="7977" checksum="D72EB693F7F6B810" modified="2020-06-17" version="1" fragment="single">MIKRGEYEFTPKEGFILAHFLTVVDVKRSADFYLRILGGKVIRDDEPTIIQIANSWLILNVGGGPTDDKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKF2</accession>
    <name>A0A6A8FKF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000456">
        <property type="protein sequence ID" value="MRN69386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="244" mass="26387" checksum="71AE6B0FF67C06D3" modified="2020-06-17" version="1" fragment="single">MNSSGMLLLAVTISMAIGVLFPQFSKIFAPYILFWLGGLLFLNLIQLNTSKLISAFVHAEEIALLSLTKLVVLPLALYAATTVVYPPMALSVLLLSGISTGLGAPFVANFVGSELPLIVVLIIVTSLAVPFVLPPIVHILFGSHFSIPVIHMIVLLAVALFIPLLAGWFTKKYAPKIAEIVSEKSLYLSIILIVLINMALFSKFSTFFFESPLFVVEMVLIAFLLFGIYGTVGYALTSFTTGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKG9</accession>
    <name>A0A6A8FKG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000252">
        <property type="protein sequence ID" value="MRN69003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="59" mass="6758" checksum="3A5DA7AC62FCD123" modified="2020-06-17" version="1" fragment="single">MTPEQRKPHQHQQQQHHKRIRVLVSKLGLDGHDRGALVICRALRDAGMEVIYSGLFCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKJ3</accession>
    <name>A0A6A8FKJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_04910</name>
        <name evidence="2" type="ORF">FIO03_02245</name>
        <name evidence="3" type="ORF">FIO04_06570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000069">
        <property type="protein sequence ID" value="MRN40366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000051">
        <property type="protein sequence ID" value="MRN60864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000430">
        <property type="protein sequence ID" value="MRN69348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="101" mass="10989" checksum="02516AB0562755B2" modified="2020-06-17" version="1">MSDNAGGDESAGAFKKAIEKGAEAQRDFVKSYSAVQQDAIHNFFSTLQGLTYYNAMFKTTVQSGGRISIPEAERQALNIGDGDLVQVIIIPIHRRKDTEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKK2</accession>
    <name>A0A6A8FKK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000143">
        <property type="protein sequence ID" value="MRN68707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="12000" checksum="AA53B1A5A7790B85" modified="2020-06-17" version="1">MNNNKQFILNQLLWIGISFGISLAISLLLPFPVSLAAIFGVFILLNMYMRRIMLRRMSSAGATGIFGSMSPMFSSNNSSSLKYYCISCGTQHKEIACPSCGSKMKKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKR4</accession>
    <name>A0A6A8FKR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_03565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000161">
        <property type="protein sequence ID" value="MRN68757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="286" mass="31335" checksum="6EEF5AE0EBDCB6C3" modified="2020-06-17" version="1">MTSTFDPNQFKMGQRQNWDSVAEGWKQWWDAFEKGAQRLSNRLIELAKIKSGQRVLDIATGIGEPAITAAKIVGTSGHVLATDISTQMLGIAKERAASLGLQDIIEFKESDAEILDLSDSAYDAVLCRWGLMLLPNLDVTLSKIHGSLVSGGRFAAAVWADAPKVPIISLAARIINEQLRMPPPLAGVPNPFSLADIKKLENHLVKAGFSDVDIETVNVTFEFASGEDYSQYCQAVSAPARIALSKETEERKESIWRKVAEEAARNYETVNGRLRMNNESICVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKT3</accession>
    <name>A0A6A8FKT3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine adenosyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FIO04_06955</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000482">
        <property type="protein sequence ID" value="MRN69422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="14">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="15">
        <location>
            <begin position="107"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MRN69422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="255" mass="28139" checksum="84CE6672FA01D998" modified="2020-06-17" version="1" fragment="single">YASDETRELMPLPISMAHKLSLKLSQVRKNKELDWVRPDGKSQVSVVYEDSKPVRIDTVVISTQHSPDIHLQQLREEIINKVVKPVCGNWVDVKTKYLVNPTGRFVIGGPQGDTGLTGRKVIADTYGGMGRHGGGAFSGKDPSKVDRSACYLARYVAKNVVAAGLADRCEVQIAYAIGVAEPVSVMIDTFGTCKIAEDEIEERVKKSFDMRPAGIISTLDLKKPIYRKTAAYGHFGRDEPGFTWEITDKVSLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKV2</accession>
    <name>A0A6A8FKV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000131">
        <property type="protein sequence ID" value="MRN68670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="128" mass="14264" checksum="664CBE5C23FC4337" modified="2020-06-17" version="1" fragment="single">MNKPIRCSMQLSRVWAHWVVKIRSFEFMILAIAFVCLSAMIASGLTTSFDKIINAHVKDVQGNEKLDILMIAITSLGDLSTLVIIGIILTIIRRTRKVGLIFLISIVFIAISIIYLKPVIGRQAPPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKW4</accession>
    <name>A0A6A8FKW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroorotate dehydrogenase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000515">
        <property type="protein sequence ID" value="MRN69478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHODB_Fe-S_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="50" mass="5674" checksum="A1E504AA5838E046" modified="2020-06-17" version="1" fragment="single">MKCGIGICASCCIEDKLVCKDGTVFCEKQLSKLNEFGMFYRDKTGRKIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLA4</accession>
    <name>A0A6A8FLA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO03_04970</name>
        <name evidence="6" type="ORF">FIO04_03930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000158">
        <property type="protein sequence ID" value="MRN61392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000182">
        <property type="protein sequence ID" value="MRN68830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="4">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="4">
        <location>
            <begin position="112"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN61392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="206" mass="23036" checksum="AC20A73EB55C410C" modified="2020-06-17" version="1">MTYMSTRQLQQKEHMEKLLLEFATKLDIHDNHVIEKADNIFKQAFTNGLVKGRSVSTMICAAIYAACHLSNIPISLGDVCSACNTKRKDLARCYRELVVELDLKITQSDSGEYIDKVINSLRSNMTNTKFNLIQQTKTSALVLVNKAKHNNLLDGRDPISSAATALYIACMMSSIDISQAEIARAVGIAPVTIRNHYKVFKQLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLA6</accession>
    <name>A0A6A8FLA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argininosuccinate lyase</fullName>
            <ecNumber evidence="2">4.3.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argH</name>
        <name evidence="2" type="ORF">FIO04_06315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000400">
        <property type="protein sequence ID" value="MRN69299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="77"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="271" mass="30827" checksum="0F245A022F88C809" modified="2020-06-17" version="1" fragment="single">MYRSRPKGNLDKDMLNFLSSMNDDLQILHYDILGSEAHVIMLHDIGILTLHETKKILVALEQIRHKPALLTTGDVEDIHESIESLIIQQTGVDIGGKIQIGRSRNDQVILDIRMKVRDDINEICEKIITLITSLLKKADENIDTVMPMYTHLRQAQIGTFSHFALSYADSLFRDLDRLYITYVRINQSPLGAGAIGGSRIKLDRQKTARLLGFKGIVRNSIDATSSRDTIIEYTMELTIMMLTLSRMTEDFIIWSTDEFGYLDISDEYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLF1</accession>
    <name>A0A6A8FLF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor IF-2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_06595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000433">
        <property type="protein sequence ID" value="MRN69353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="4">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="167" mass="19017" checksum="10153F87D940196D" modified="2020-06-17" version="1">MRNRQSDAVPLRITHINPENITPFVTVQTRSDYESLLKRLQDKLGNESRKAVSRLEVPTPQIIWVGQRTIFRNFMEFPKALRREPPKLLLYLNKELASAGYIAGERVIFLGRKEPSSFGALIDRYVKDYVICPVCGSPDTRTEKNKKLGFLLCEACGARSSIKANYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLG8</accession>
    <name>A0A6A8FLG8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="4" type="ORF">FIO04_04240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000204">
        <property type="protein sequence ID" value="MRN68890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="154" mass="17301" checksum="3BF68916D64D24B7" modified="2020-06-17" version="1">MSTKTEQRALVVNGAGCIAGRMCSHVSKLLLQGNRVTIVNAEKAMLSGHRYKTIELYKEHLEINSATNPIHGPFHPRRPDRILTKMVRGMVPKRKASGIEAFKRLRVYIGIPDQLKDSKMEFFEDSKITKPASYYITIGDVAKEIGWKGEMLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLL9</accession>
    <name>A0A6A8FLL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000483">
        <property type="protein sequence ID" value="MRN69423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="131" mass="15062" checksum="22D148045D5854E1" modified="2020-06-17" version="1">MAKILIVDDDSGITLAFKKGLESDGFKVDTFNDPLEALSNFEASKYDLLLLDVRMPKMNGFELYKELEKIDNGIKVCFMTAFEVYYEALREVFPSLEVECFIRKPIEIASLIKKIKNELNVSKPRSQNLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLN6</accession>
    <name>A0A6A8FLN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000233">
        <property type="protein sequence ID" value="MRN68960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="177" mass="20004" checksum="5EB128BED3FF31A2" modified="2020-06-17" version="1">MFYHGIGLLLMLVGISIVQKVISNYEEPSLPHYLALVLSAGPTEESLFFGIPYYAFGNHYVVLAGGIIWAMLHIINTHTLDIHNLAYANWLFVIPSFFFSFRTWISGKGWFAILTHSGWNGIFFTLGCVYRDYPCLIIPNGGNYTLTLSSIMLSIILVGLTYVLYRRKKAAHIHVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLQ3</accession>
    <name>A0A6A8FLQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000310">
        <property type="protein sequence ID" value="MRN69127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="184" mass="21491" checksum="9DD2D17055B68109" modified="2020-06-17" version="1" fragment="single">SQKLLIAMGDIQYQLKFLEKSGLIKSRHIWLYKTYYTFSILGERYENILAILQQETPRDVILYLIENPGATQSEIVRHKGFTAPTINWHMSRLIEIGLVYSCKEGRFVKYYLEGNVEDIITLLKLYHPSVWNKLSNRLAELFLDIASQSRPGRDGAGEKNDASENTNEQAEERREIEDRMYKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM67</accession>
    <name>A0A6A8FM67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000316">
        <property type="protein sequence ID" value="MRN69140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoMet activation" evidence="2">
        <location>
            <begin position="53"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="316" mass="36199" checksum="51BE3BAFF2DEF93F" modified="2020-06-17" version="1" fragment="single">SSYINRIAKEGGIYDSGVFYCKTAFEGLTVMNKLMSDERKAYVSEWHQKLERWEEKRGPATQSVKLPHSGIKPVHAPIPPHIARRIRLEAEQISLNEIWKFINKKSLFVLSWGFRGRGAKGLSEESEKLFEEWKKRVIEERLFDPKVVYGYFKCHNRDNNLVVELVDGKGEVSFDFPRSSKEKNLCLTDYFGENDIAAFQAVTVGDKVTKIIDEWNKENKYTDAYYLHGLAVETAEALAEWINSRIKSELKIGNKGGLRYSWGYPSCPDVSQHHLVWRILDPTKSGMSLTEAGQIIPDQSTAAIVVHHPQAEYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMD9</accession>
    <name>A0A6A8FMD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000352">
        <property type="protein sequence ID" value="MRN69210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="117" mass="13261" checksum="0211F19EC2D2BB94" modified="2020-06-17" version="1">MYANRLSRGWIRIAGHYDSYEANNAKSLIFPSDYDSTSMFWLINAKGAFGGRAGLLPVFVEIIKGTFRKASEVENPNLACRDIEKRYCSSPRSTFARMISLFKNSKQYRFGNLNGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMH0</accession>
    <name>A0A6A8FMH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000471">
        <property type="protein sequence ID" value="MRN69407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="194" mass="19255" checksum="7EBC2AA4168CE910" modified="2020-06-17" version="1">MYISTRGTSTIFVIMVVAATTLMLLTSNTITGSVFAAKTSISHHSGKSNGKTSSTGSGNSSSSISATDSTNNNTPSTISNANPNMDNLLACESAAGHGSGQLTKAEVMNCYLQFSRGSASSLSIIGNANNSPGNAGSGSGSGSTSTTHHAGSSTTHHAGSSTTHHAGSPTTHTNSHHHSATNPSGLRGSTTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMK5</accession>
    <name>A0A6A8FMK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000497">
        <property type="protein sequence ID" value="MRN69447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="88" mass="10341" checksum="40E877823C17D251" modified="2020-06-17" version="1">MMKEKIKVNNNAYNVTLNDQTQMYAMRLRRLYQQTYTDVDSFDEVSSEISTTVNNLLKHAVSPEVKEDDMDGVIQQLLKMYEKSFQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMR3</accession>
    <name>A0A6A8FMR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000418">
        <property type="protein sequence ID" value="MRN69330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="109" mass="11622" checksum="FE67EEE258193AFA" modified="2020-06-17" version="1">MTTRQKSKDSLESAATEVPYKKRKITLASLIIALSVSIAIEIGFSATFSQGFGSTSDSYKHALCAAKILDLSQKGVIRDTGGFNGAMLECTQIKSTSSIYGDVLSAHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFL8</accession>
    <name>A0A6A8FFL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_04365</name>
        <name evidence="3" type="ORF">FIO04_00570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000128">
        <property type="protein sequence ID" value="MRN61275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000015">
        <property type="protein sequence ID" value="MRN68175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="171" mass="18973" checksum="CBD61F535A5F37E2" modified="2020-06-17" version="1">MPKKAKRQQNVKNSKFTFSKYKYAIMIFVGIAIVVVIAGYFGIHSLIPVNGNTPAFAPPINTFMKASHSPQTGWLFTSQSTAASRSNGMGAGFNSPTIFLKYGALDSIHLINEDADTRSLHNLNIDTFNVHTKSLGYFESQSLTFIANKIGTFVYYCNIHPEMRGLIKVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFV1</accession>
    <name>A0A6A8FFV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_00725</name>
        <name evidence="2" type="ORF">FIO03_01045</name>
        <name evidence="3" type="ORF">FIO04_01085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000005">
        <property type="protein sequence ID" value="MRN39558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000018">
        <property type="protein sequence ID" value="MRN60628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000033">
        <property type="protein sequence ID" value="MRN68275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="74" mass="8739" checksum="8F03746BADC47297" modified="2020-06-17" version="1">MVRTYEEWWKTVPEDLRKKSRKGDEQNKPLLNQVNYVLLHLHLAGKHDAKPSHAELKDWLHSGQVDVLRMAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG01</accession>
    <name>A0A6A8FG01_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">V-type ATP synthase subunit F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpF</name>
        <name evidence="6" type="ORF">FIO04_00510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000013">
        <property type="protein sequence ID" value="MRN68164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00312">
        <property type="entry name" value="ATP_synth_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022944">
        <property type="entry name" value="ATPase_V1-cplx_fsu_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="116" mass="12807" checksum="0C94375F832B727E" modified="2020-06-17" version="1">MSELISRKGLTRKIAVLGERELVMGYRLIGIEDAFIVSTDVAEVNKKLQQLMSSKEFALIIASNSVRYALSEGFRESVEASIEPLVLFMPAFEGNIQEESIASLARRVLGISIQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG10</accession>
    <name>A0A6A8FG10_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="1">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">carA</name>
        <name evidence="4" type="ORF">FIO04_00565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000015">
        <property type="protein sequence ID" value="MRN68174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="419" mass="46837" checksum="CC4A57B2AC30F880" modified="2020-06-17" version="1">MIEDGSIFDGIGFGYPADIAGEVVFNTGMVGYTETLTDPSYRGQILCLTYPLIGNYGVPSIEDSDEFGLPRFFESDRIQIRGLIIHDLSIVASHWSCVKTLDEWLYDQRIPGICNIDTRELTKKLRINGVMMGAISTWAVQEGVAANSEIDVRKRLSRLIKNQQYGQQNFMPEVSTSIPRVYGDEARDTLVLLDTGTKNSIIRNILRIGFRVVRLPWDSSFEEVMLHKPKGIVISNGPGDPKVCKTAIKTAGELIRASVPTLGICLGHQILALAAGADTYKLKFGHRGQNKPCIDLRSNRAYITSQNHGYGIEPKSLNGTGFKVWFSNVDDHTVEGIEHESKPIIAVQFHPEASPGPYDCIFVFDRFKELLDDFNRRSSSARTTESNNENNNNNPKVKMSAARKKKTTKEEEICQNMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGG0</accession>
    <name>A0A6A8FGG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000048">
        <property type="protein sequence ID" value="MRN68351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="52" mass="6205" checksum="E7175E789DEADC4E" modified="2020-06-17" version="1">MADCPLCTGARGINKKEEFIEHLDSHQEMAMNHDMMFRKFKEYVLTHENFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGK1</accession>
    <name>A0A6A8FGK1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_01550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000050">
        <property type="protein sequence ID" value="MRN68364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_L15e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="155" mass="18373" checksum="D5199E2BE664865D" modified="2020-06-17" version="1">MRGYMAATWLKMWKLNTDELKSKAITWRTEHAIQRIERPSRLDRARKLGYKAKQGIILVRARVGRGGMRKQRPVSGRRPKHLGVVHIKQGISMQRVAERRVLESFPNMESLGSYYLHKDGRYFWYEVILADPYHPSISHDKEMRRRLKAFAKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGK6</accession>
    <name>A0A6A8FGK6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="100" mass="11297" checksum="1591E9F19319D20A" modified="2020-06-17" version="1" fragment="single">PEYPMEHAQRGGHIPGAANVPWAQAIKEVDGTFKSVQELRSLYDGKGVTPDKEVIAYCRIGERSSHTWFVLKYLLGYPSVRNYDGSWTEWGNMIGNPIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGL6</accession>
    <name>A0A6A8FGL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000007">
        <property type="protein sequence ID" value="MRN68126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="228"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="420" mass="46957" checksum="4A6D01427C95454F" modified="2020-06-17" version="1">MKVSVLGAAKEVGRSAFLVNVNSTGILMDYGVLLKREPIFPMHVRPKDVDAVVITHAHLDHSGFVPSLFLSESTSVQALGTPPTFELSRLLIEDMIKISGFYLPFEYIDVITMMKNSKNLQYKETYMVNDVKVTLHESGHVLGGASVILEHNGKRIFYTGDINTRGSKLLRPADLDFGEIDLMIIESTYSQSEQMPRDQAEKELLEFAYDVLERGGTLFIPAFSVERAQEIATVLKSNNFRHKVVMDGMALKANQIMMKHPTFLKDAEIFKRAINEAEWISGWNRRRSVVKEPCVIISPAGMLVGGSAVFYLQEIAKSDKNGVAMVSYQGEGTPGRTLLDRRVVSFDGRERKCLADVKRFEFSGHNSRSELFEILEHIKGNPKVLTVHGDGPSCTKFAEEIKIKYGFESKAPDTGESIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGM0</accession>
    <name>A0A6A8FGM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysine biosynthesis protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_04730</name>
        <name evidence="2" type="ORF">FIO03_02060</name>
        <name evidence="3" type="ORF">FIO04_01685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000066">
        <property type="protein sequence ID" value="MRN40331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000046">
        <property type="protein sequence ID" value="MRN60829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000054">
        <property type="protein sequence ID" value="MRN68391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13946">
        <property type="entry name" value="LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="PTHR40393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN60829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="57" mass="6072" checksum="C37184EB91468F73" modified="2020-06-17" version="1">MKKECQDCGADINIPDDALVGEIVTCPDCGADFEIASKAQNMVDLKPAESVGEDWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGM4</accession>
    <name>A0A6A8FGM4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
            <ecNumber evidence="2">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnA</name>
        <name evidence="7" type="ORF">FIO04_00370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="106"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="493" mass="55460" checksum="A6AB395377A7F356" modified="2020-06-17" version="1">MIIDTGYIQLRYTDVLGKFLAKYVFENKETFDSFFKCGIGVDGSSIKGFASIDDSDLLLVPDRSTVRIFPPSLLSASPSPLSSNYNNKLFAVIADVYQGFKKGRLVRDPRYVSQRMEEFLIENNLTCQMGPEVECFVFDSIIFNHKNNNNDLNSDRSDDNSEYHEPKILSVEGYGGDGCKYPIRRKGGYDAPPFQDSLLEFRFDVAEILRKHFSINVTNLNHEVASCGQIEINFMHSTLTKAADSVQIYKDVVRNVARRYNKVANFMPKPLFDKNDPLNGGDNGSGMHTSISLWNESSTTNIFYDSDDYYAELSQIGRYFIGGLIEHAHSLAAIVAPTINSYHRLIPGFEAPVYIAWAKGNRSTVIRIPINERNNAKSKRIEFRAPDPAANPYLAFSAIVAAGLDGIKKTIDPGSPTDENIYKMSDAKRNSLGIKSLPGSLEEALESLKSDSNYLKRCFHDELLETYIVLKYEELANARDISIAQELMLYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGR1</accession>
    <name>A0A6A8FGR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded DNA exonuclease RecJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000118">
        <property type="protein sequence ID" value="MRN68625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="346"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="479" mass="52049" checksum="4C10C86E36046425" modified="2020-06-17" version="1">MYGRGLEEAVKPFCEKIRSVAEDDSNTCIMTHLDADGLISASIISMTLLRLGAKCVVRPISDMVPAVIEQMKSEAHDFYIISDLGAGLGAALNDALGDRWIIIDHHQLPDEELTGPYSAQILNAFKYSIDGGSEISSGGLAYLLANQIEKRNWDLSPIAVVSAISDNQDQGDKKSLISINSEIIKTAESHGLITVDLDLIFTGRETKPLHEALASTSFPYIDGITWNRENAYAVIKNSGVRMMENGRWRVLAEIPQEEKSIILDAIVKFVATSSKYKTANLTENLVGYTYTLVNEDLRSQLRDAREFSTLLNACGRTGRAGIGVGICMGDRYVCLTEGEKIADTYRAILAKSISTILTEKWRTIDNGRSIFVNAENLLAEEMLGAVSSLLSGSPTLGDRVLFVWTVSRDGMHKFSCRKCIGCKSGSDLGLVVRNCAESVGGIGGGHKAAAGCKVPSSRLEDFVSCVRRAILDSKFTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-02-10" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGS0</accession>
    <name>A0A6A8FGS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-intron lyase</fullName>
            <ecNumber evidence="3">4.6.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">endA</name>
        <name evidence="3" type="ORF">FIO04_01945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000066">
        <property type="protein sequence ID" value="MRN68441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016442">
        <property type="entry name" value="tRNA_splic_arch_short"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005285">
        <property type="entry name" value="tRNA_splic_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="1">
        <location>
            <begin position="87"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="180" mass="20472" checksum="F1B9E1FAB1B51B04" modified="2020-06-17" version="1">MKGILVENRIIVWNIEHSRALFGNGYYGKPLGVPKPKGIQFDSPLILDLMEGCYLSQIGKLEISSNGGRRLSSKDIRAICKKEYANFEIKYMVFQNLRDRGYIVSPSLKFGCDFAVYEQGPGIDHAPYLVQVFKPTDQMTATGIVLFGRLATTVKKQFILAIPRTKDRKVDFVGFEWWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGV1</accession>
    <name>A0A6A8FGV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_02155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000076">
        <property type="protein sequence ID" value="MRN68481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="4">
        <location>
            <begin position="294"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="689" mass="76970" checksum="4297381584B92BBA" modified="2020-06-17" version="1">MSEQQTLAALSNNLEKFLRSFKDKDGTYKYFDSINHMMASNSVSLVVDYIDFDTFRPDLAKHITHNPDEMLEAFNAAVLSILTEIHPDYALEIRDKIKVRIGNYTVQKGLRDINAEVIDKLIGVSGMVVRSSEVKPLAKKIGYRCLNCNTITEAQLKGLQLRKPLKCMNCSEKELEMDPENSIFSDFQMVRLQELPEDLPAGQLPHYVEVTVMGDLVDQCRPGDRIMLTGIIRIEQDQISPQVKTSLFRLRMEGNNIEYLGGRAGSKEMRTVERIAISTEDEKQILAIASKPDAYDKLIASFAPHVYGHEVIKEAILLLIVGSVTKKLEDGSTRRGDLNIFLVGDPGTAKSEMLKFAAKIAPRGLYTSGRGTTAAGLTAAVIRDKSGIMMLEAGAVVLGDQGLVCIDEFDKIKPEDRSALHEVMEQQTCSVAKGGIVATLNARTSILSAANPLYGKYDPFKNITENVNLPIPLLTRFDIIYVVRDTPEKEKDSRVASHILELHRDSGRAAHPAIDIDLFSKYLAFSKQIEPRLTIEAIDIIKNYYMKMRNVDSEGMITVTPRQLEGLIRLSTARARLLLKDKVETDDAERAIYLVQRMLETAGVDVNTGRVDLGVLHGKPHSEISKLKVFMEVFNALSGQDKNDVEEKNFINELAKTGKFTEEEARTFIKKAMQNGQIYERKSGSYAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGX7</accession>
    <name>A0A6A8FGX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000022">
        <property type="protein sequence ID" value="MRN68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="361"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="533" mass="61083" checksum="B3233679AAE17CAC" modified="2020-06-17" version="1">MPTPSVPLGLNYTHLRNDVLLDIATFLSRRWSNNNKTVIILTQDKMPLAKIDKNQITLPFLNYYLGTSFQQYRQWRVALWHESMRMHHSTKVLSYEHAFGFLLNTIETKRVEILGLQDWEGMIKEIVFNEGMSWLSRPLLNSIYGKSKIIEAFSQYFLTGYLKGELYGNDLEKVKKASSFANEIVHDAIKNDYHTDWIERHIPQLIKMLELDALTSVAILAPRTRIIGLGMNQSDLVKQIEKIVRRNIKATDLDRTSREIIEGTDVLGEFQTLLKESKKTENKGYESLENLGLSVPEMMDVDPSPIYDADLIRKVKAKFRDWRTGWIERHEVAGEEFDPESYVEMLPKNFLTDLKLSIKTKVAILLDHSSSIEHVELEYKRATVALCEALSYLGIKFAVYAFSTESGQVKCWIIKPPNLKWSATGPRRLTQIRASGGTPLAEIYGLLQPIAKSFKPDIMVTLTDGEPSDFDAVREMVLSYRKMGIHMVALGLGKNFNDAISIGHNLKYLTYERSLAVSRLEDIPKKVIYLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH25</accession>
    <name>A0A6A8FH25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_01300</name>
        <name evidence="3" type="ORF">FIO04_02510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000010">
        <property type="protein sequence ID" value="MRN39671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000094">
        <property type="protein sequence ID" value="MRN68551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN39671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="162" mass="17761" checksum="EB04D205AD503590" modified="2020-06-17" version="1">MVFPNPVYIAIAAAVFTIFWIAFNVFDQLLFFSPVVTFYLPDDAIAGFILTNITSVLMGVLVAMNVYVIRNSELKLDKSLFSGSILGIASSTCASCSSIGFLVISTFGGFGIIATDFLTNYQIPLRIVSIGILLWALYSVHNKITKPCIFDSFKQQKQPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH64</accession>
    <name>A0A6A8FH64_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisD</name>
        <name evidence="11" type="ORF">FIO04_00280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000006">
        <property type="protein sequence ID" value="MRN68118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="430" mass="46404" checksum="98E6AAAF3E44EB3A" modified="2020-06-17" version="1">MKTIIITNAKEDAAKLRNSGISISDQLIQGVASIMNDVAERGDAAIIDYTEKLDGVRLNSLKVTEEEFEQAYSMVTKKQIQAINVIKRRLMESEVSVMNHLKGITILSAGIKVHRLIQPISSVGCYIPGGNARYASTMVMCAVPAKVAGVKRIVAISPPRRDGTVDPLTLVAARICGVKEFYKIGGVQGITALAYGTPAIERVSKIVGPGGMFVTAAKFLASRKVSIDMVAGPTELLVYADSMSDPKLIALDLVSQAEHSYDTFCGLVTTSKQLARRVSAEINYILKSNSISRADIVRKSLEKNGFIAICKQRSTAVEFINEIAPEHLQLVGKNARATSKKITSSGLVLIGKYTPSSASDYCFGSNHILPTLGFGKSRGSLSVLDFLKLVSTIEATKSGLEKVQHNIREIASAEGLINHYLAVQERTMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH65</accession>
    <name>A0A6A8FH65_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps4e</name>
        <name evidence="10" type="ORF">FIO04_01190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RS4NT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_S4e" evidence="7">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="238" mass="26208" checksum="D269220AB75D6269" modified="2020-06-17" version="1">MGKKGGDTRLKRQLAPRFWNIRRKQSQFVLKASPGPHRKHGSYPLGIILRDVLSVSTTMHEAKTIVSAGKVKVDGIQRRDVKFPVGLMDVIELTPTGQSYRFVPKDSKLLVPVEIQDAEKMLKFVKVSSKVTTKGSKLQYGFHDGKTMISEQPLSVGDTCLLDFQNFTIKNTVRFEKGNLGLITSGDNAGSFGTIEDIKDGLFSLPKRVILALGSRSVELPTDIVMAVGLEAPLIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH77</accession>
    <name>A0A6A8FH77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000109">
        <property type="protein sequence ID" value="MRN68601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="48"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="179" mass="19613" checksum="7AC6EE1A8C16594A" modified="2020-06-17" version="1" fragment="single">TFGVGHMIIENNIIRNSGHYGLDPHTGTHDMIIRNNKVYDNNGSGIICSLNCYNILIENNKVHDNTGDGIDFSRNMYNSIARNNIVYNEPAGVLVSQSHYNQIYNNTVSTSGNGIYVNSGSTNNKMYDNTIMNSNLHAILINNGSSGNTFTSNKIVGTTPQGLKISQDSTSQNTFSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH83</accession>
    <name>A0A6A8FH83_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylosuccinate lyase</fullName>
            <ecNumber evidence="5">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">purB</name>
        <name evidence="10" type="ORF">FIO04_01295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000040">
        <property type="protein sequence ID" value="MRN68316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="9">
        <location>
            <begin position="362"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="461" mass="51752" checksum="648A82AB58C454D2" modified="2020-06-17" version="1">MPILPIDTGRYGSPQIKRIFEERDRLQYQLEFEAAVAKAQAQINMIPVSVAKEIVKIAKSDKITLERVGKLEAISEHDTAAVVEALSEKCSAKSKPWIHYGLTSNDIIDTTISMQMRDVFRIIEPKILRLALILADRSVEFRAQPAVGRTHGQHTSIIAFGLKFAVWAAEMATHIERIEEGKKRFLLCKTLGVVGTGSLMGKRALEVQKIVAENLSLHPVDAATQVIPRERIAEIQFLITLVGCTLDKIATEVRNLQRTELGEVAEHFRKGQMGSSAVPVKRNPIKSEKVSSLARLLRSLIGVALENIPLWHERDLSNSANERFTIPMAAILLDEMLNSLMSVIAELKINTQRLTSNLDMTKGQIYSEFVLDALVKKGVPRITAYRDIQRVAFSALQSGQHFRDAIKRDSHLARKLSSEELKYIFEPNNHLGASSEIIDHVVNKVRNTRNKYFDHKSKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHF5</accession>
    <name>A0A6A8FHF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000205">
        <property type="protein sequence ID" value="MRN68895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="96" mass="10456" checksum="99B4F0E570661B5B" modified="2020-06-17" version="1">MTLIIVAIVMIAGALAFMSIQKSDAQLKVIQSEQQQKLGQLNDCGNNATCTNIGSLSFMISSQATNDTKLNYIARQANSIKDYAQKDTTPFILPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHG2</accession>
    <name>A0A6A8FHG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000210">
        <property type="protein sequence ID" value="MRN68905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hcy-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="296" mass="33010" checksum="DC3709948688E29A" modified="2020-06-17" version="1" fragment="single">EIQRLNPQPRDFPDNRDGFNDGLILSKPEWIKQIHRSYLKVGADCIETNTFGSNYLKLAEYAYEDETLEFNKKAASLAREVCEEPEFRDRQRYVIGSMGPTGYLPSSDDPDLGQKTTDQIKEAFLPQAEGLILGGVDAVLIETSQDILEVKLAIEACHDVIKKVGKKVPIIANVTLDQYGKMLLGTNIQAAYTTVSDMEIDVFGLNCSTGPAEMTPSVRWLNEQDELPILVVPNAGMPQNEGGKAVYKMTPSALSEKLKEFIENYKHVRIIGGCCGTNPLHIAEMRKMLDLYQGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHG7</accession>
    <name>A0A6A8FHG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_00840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000024">
        <property type="protein sequence ID" value="MRN68228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_HSP20" evidence="3">
        <location>
            <begin position="328"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="394" mass="44327" checksum="18A1E38C37F58642" modified="2020-06-17" version="1">MLRLIIYTGKGGTGKTVSACSTAIKLAENKYRTLLISSDPAHTLTDAFAMPDLGYEPKEILTNLQALQIDPLMEMNKQYTTILSYMATLFHARGIDETLAYELAMLPGMTQLFSLLKIEEVSRTKRFDTVVLDMAASGEALRYLYFPKLVGSIGRKLTGLVGMFSGFARIFQPLSRLPTPPQNVLENELELLAKLDNLNMIMMNQDITSIRLVTNPDTFSIENAKRAFMSASLYGINVDLAIINKIMPAGSSDLYYAEWADFQRVKIEEAKANFYPLPVKEVKLYGTELRGIEMLRENGQLMFENQDPADVLFRGNVFHFAKENSLLRMTVKVPFTEKDDFDVERYSDKLTIKVKTRVGYMVNTVPLPAATTGMKLTKAKLQGDELTVLFEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHJ4</accession>
    <name>A0A6A8FHJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">coaBC</name>
        <name evidence="6" type="ORF">FIO04_01120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000034">
        <property type="protein sequence ID" value="MRN68282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="5">
        <location>
            <begin position="204"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="209"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="434" mass="47407" checksum="CA276C6972B8FF9E" modified="2020-06-17" version="1">MHLANKRGTHPSKDIVATQGKEILGKKIVLCITGSVAAYKAIDLARLLMRHGADVYAVMSESSTSTLIKADIMKWATGNEVVTKLTGKLEHIALADTGMSDLILVYPCTANTIGKIANGIDDTTVASVLTVALGSRIPIIVAPAMHESMYTNDIIRQNVDRLKDIGVKFLEPSVEEGKAKIMEPELVLQSVMRELNEMHTSFSLEGKNILVTAGSTVEHIDPIRVITNLSSGKMGIAIAEGALLAGAKVTLVYGHGSDGTRVPMKIRNVIKVNTSREMEMTILSELSSKRYDIVIFCAAITDFAPQQTSPKKIETKKGKFVLPLLPTTKIVDRVKPISRNNKLFLVAFKAEHDVSDSYLINKAFQKLHECDGDLVIANDLGRKGCGTGSDENEVFIINRQKKVIHLPLQDKNQVARKILDTIANLCQVQKDSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHL9</accession>
    <name>A0A6A8FHL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_01225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000037">
        <property type="protein sequence ID" value="MRN68302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="227"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="362" mass="38869" checksum="993E20FE18A00B63" modified="2020-06-17" version="1" fragment="single">AGYATTKFRRKSEVSLFEIACEPCRNILTEYEILKKEIDAVLFSSCSVEQYSSSIISEMLGLSPKISHRIDNLCNSGTNAIACAFSYIASGLCDSALVVGAEKIDTPGRRLTWDITRGEYGLPVHWAALFAKAHMRKYGTTEEQMAMVSVRNHLNAAKNPDALFGEPITYDEVLNSRQIVPPIKLLDCSSLCTGSSAILLVSDKKARKITENPIWIRGIGQQTNCASFSKVATDLTSIQAAKQASADAYSMAATDPLNIDVVELHDAFTILEILAYEDLHFAKKGEGGKFVNQEEISINPRGGILGCGHPIGATGVAQAAEIAMQLDGKAGLRQVKGCKTGLVHNLAAAGTSATVLILGIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHN7</accession>
    <name>A0A6A8FHN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_04670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000239">
        <property type="protein sequence ID" value="MRN68975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="53"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="520" mass="57360" checksum="0E8F540F1670A825" modified="2020-06-17" version="1" fragment="single">MPFENEHTLQKFIASKEEESFHDQYEQAIRDVKSEFGKQYPLIIGGTKIKTDSTFTHLSPIDTRIVLGYLPRSSVEDTRNAINAARDSFDWWRKHNYKKRMEICRAGANVLSRRKFELAAWLSYENGKNRYEAIGDVDEAIDFIRYYCECMETNEGFSTLTRSAYPAETSRSVMKPYGVWGVIAPFNFPAAILIGMSIGALITGNTIVLKPASDAPIIGYKFAEVMEEAGLPNGVLNLITGPGAQLGQEIVGNEHVAGIVFTGSKKVGYEMIRRFNKTKPRPIIAELGGKNPAIVTESADLDEAVQGISNAAFGYSGQKCSACSKVYVQKIIKTEFVEKLVKRSKSLQVGNPLEPSTFVGPLINVGAYKNYQRYTTLASQDGKLLIGGRINRSGDLKYGLFVEPTIVDGLPEGHRLLTDELFVPILCIIVYENLEDAIRLCNSSQYGLTAAIYTKKKEEIETFIESIESGVVYVNRALSATTGAMVGCQSFAGWKGSGTTGIGAGGPYYLTQFMQEQSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHP4</accession>
    <name>A0A6A8FHP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000162">
        <property type="protein sequence ID" value="MRN68761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="159" mass="18258" checksum="4634DF0AF25A786C" modified="2020-06-17" version="1">MAGSAIILMSTPSAPSNVTISNNNTNMTSTFHHSYEILINDSRLLTQNYQSEIGKWRIKQYDNKTMMSVTDNYLPMFQKSVGGVEALKPTTENYIQAKEWYTKSLQSEIESYRHFRNFLENGSPIEDEKSTQLLSDALRYEFNSFAAFNNQTNNQTPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHQ0</accession>
    <name>A0A6A8FHQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MTH1187 family thiamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000078">
        <property type="protein sequence ID" value="MRN68486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="112" mass="12183" checksum="3DB23DC8A1FCD3E2" modified="2020-06-17" version="1">MSTNSNQTLHAEISIVPVGTGSTSISKEVAAAFEAIRKTKDITTTKLTAMGTQIEARNMRAILNAIEAAHEAVKSTGAKRIISTIRIAERLDASKRLEDEIESVTEKLSKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHR0</accession>
    <name>A0A6A8FHR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000002">
        <property type="protein sequence ID" value="MRN68089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="140" mass="16055" checksum="B0F5C4A6D9C86863" modified="2020-06-17" version="1">MDFFIPLLSLLFLGVMYILITRINQGYSGFLLVSAASVLMIYWVRELKRTVKDEDSKPLPGDVDTKDWVYDLIKNKNEMVFVAEVPGPEEQIDIRLTIGTLHVKSGQNFSKTIPLDLIEEMNISDFKYRNGILTIKINKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHS7</accession>
    <name>A0A6A8FHS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000170">
        <property type="protein sequence ID" value="MRN68791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="134" mass="15438" checksum="7697446D57FB7308" modified="2020-06-17" version="1">MDRIQQKQESRLQPKLSVIFKQQVNRIPQTFGAFYDGEGKYCALSAVSKCFGYDVEAHKMINDAIASSADLIPPTVIERIEGCLPIRCVEEYPRCNCKTKNYYHYSLISLLIHLNDYHQMTFLEIGNWLESKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHT7</accession>
    <name>A0A6A8FHT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000050">
        <property type="protein sequence ID" value="MRN68362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="39" mass="4318" checksum="B4BBD321E65AE34F" modified="2020-06-17" version="1" fragment="single">MKAVILAGGLGTRLQPYTFFIPKPMLPLGNKPLLEHIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHZ4</accession>
    <name>A0A6A8FHZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_06305</name>
        <name evidence="2" type="ORF">FIO03_05315</name>
        <name evidence="3" type="ORF">FIO04_04085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="3"/>
    <dbReference type="EMBL" id="WJXE01000105">
        <property type="protein sequence ID" value="MRN40638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000174">
        <property type="protein sequence ID" value="MRN61455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000194">
        <property type="protein sequence ID" value="MRN68861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="252" mass="27304" checksum="B9F80E9EA15A64A1" modified="2020-06-17" version="1">MSLKGKVAIVSGAGTGVGKATTKRLFSEGAKVVLIGRDRSRLTKVISDLNGKKNLLAVKADITKEADVINVIEETVSAFDTVDILVNNAGILNDPTPFHKMTDEQWMSLINTNLIGTFRTTKAVLPIMMEKRRGSIVNISSLQGIRSILNVPFSVYGVTKAGVIMFTRTIAVEYGEYGIRCNCVAPSTIRSPMIEPYLQDKQAKKTLESSFPLRRIGDPEDISGAVSYLCSDDAKWITGTVLTVDGGMSAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI28</accession>
    <name>A0A6A8FI28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_04275</name>
        <name evidence="2" type="ORF">FIO04_02000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000056">
        <property type="protein sequence ID" value="MRN40243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000069">
        <property type="protein sequence ID" value="MRN68452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="49" mass="5221" checksum="FE933F966752E94E" modified="2020-06-17" version="1">MVENSLAKRIVDDVLNATSTGSYYDGRIIVSDIAEAYVIGSKETGDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIC3</accession>
    <name>A0A6A8FIC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="7" type="ORF">FIO04_02410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000089">
        <property type="protein sequence ID" value="MRN68532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="329" mass="36632" checksum="744990F3F53A7603" modified="2020-06-17" version="1">MIAAINLSVPDVVDSETERTVTGVLKCPSCGSKEQKLFVVDSSSGETICQKCGAILEINNIDQNHEWSAFNIEEFNDKARTGTPSSLARHDMGLFTVIGRTDKDASGGKIDPTVRSTMERLKTWDYRTQIHTPAARNLRQAFSELDVLKAKLGLSDAIIEKTAYIYRKAQERRVVRGRTTSAILAASIYIACREIGMPRTLKDISTVSNIKRKDLARSYRFIVSKLELKIPVLDPIKCIVRVANKANLSEITKRKAIDLMYKINENELAAGKDPMGLAASVLYLSSMNNRDSNEHRTQSDLAAAAGVTEVTIRNRTQELRKKSCLKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIF9</accession>
    <name>A0A6A8FIF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_04900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000261">
        <property type="protein sequence ID" value="MRN69021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="17"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="261" mass="28398" checksum="61905890265F8426" modified="2020-06-17" version="1">MVSAINSNFVEIILGKLYALWLREFKVFLRERSRLVASIFTPLLWLFVIGSGFGSAVHPSTGVDYQMFIFPGIISMSIIFSSVFFGSYIIWDRKFDFLKSVMVAPVGRNTIFVGKTLGGMTTSLVEVVILLAVGAAIGIHFSALSLVQTIAIVLLLSFSLTSLGLIIGSYIESLEGFQLIVSFVVFPLFFLSGALFPLRNLPGWLSVLTTIDPATYAVDALRNAILGIQNYSFTADIGILVAFTIGLGVFGGYSFGRMKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIH3</accession>
    <name>A0A6A8FIH3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoeA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000270">
        <property type="protein sequence ID" value="MRN69041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoeA_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="161" mass="17239" checksum="22854ADE70EB15BD" modified="2020-06-17" version="1" fragment="single">MTLKPITYLSIGAAYKSLRQNIEVQPQAELISVLESYGRVLSEDVISDVNIPMYDSSHMDGFAVLANDIKHASDSGPITLKIVRNVGLGKVPSDVLHSGQACRISTGGNLPQGADTVVPVEYTHESKDKVGILASLPKGAFVSPLGKDVRRDSLLLNRGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FII7</accession>
    <name>A0A6A8FII7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000106">
        <property type="protein sequence ID" value="MRN68592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="162" mass="18316" checksum="506DAEA54287AC22" modified="2020-06-17" version="1">MSDLDVKDVGEFIDDLRKTSNGGVSIQGVRADAVYGLEHILQALKITIESEKRKITLVERPEMDLLLRISCTDQISRALKDIGLRNQAPGCFILFSKEKKKLIKVTRRICNTHLKIDDSVLKPNKTKKELICRRLGVQLNKFLSNDDAFTSYLSEKAALLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIJ0</accession>
    <name>A0A6A8FIJ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000289">
        <property type="protein sequence ID" value="MRN69084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="282"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="468" mass="53410" checksum="F227F4399EEFE4E3" modified="2020-06-17" version="1" fragment="single">MNPSNNTDDIESKEIHSKCALCGKSASGQGESTRIQEVIGGTSYTFDTQDCLNMFKRFKSVYGDEFKGFLAQEQFISDPFWDRAIPKEEEIREIEIEKGRVKPDIIQVIQDLGEIRKIASEIVRTARHEILIIFSTSNAFHRPEHIGGIQLLKDTLTKTTTPATTKRDLNIRILTPLDDQIKATSPELKEQLNIDFRYIEESLQTKMTILVVDRVFSLAVELKDDERNSTYEATYSRSKSTVLSYVAIFESLWKQVELNEKVNKLYEQLKIEDKLHRDFINVAAHELRAPIQPILGLTEVIRSRKGKLNANEQEELLAVIIRNAKRLKTLTENILDINRIESRSLSLNKETLDIDDVILDAIQDIENQIDNKQDLRILHDSKRKGGEEQEGRTFMKADRNRITQVISNLLSNAINFTKTGTIHVYKETEKDGSMRVIVKDTGTGIDPEILPRLFTKFTTKSNKGTGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIK5</accession>
    <name>A0A6A8FIK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000051">
        <property type="protein sequence ID" value="MRN68369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="131" mass="15134" checksum="AE154325892A12A0" modified="2020-06-17" version="1">MARTGRQGRQIRKVMILEDEQDILHLYKDYLSAKGHSVIVTSTTANEAMDDYEKYRPDFVIIDYKLPGKKNGLEAAKEILMSYPSGRILMLTAFHGVKDELKKDFFFDDKMIQILIKPVKLARLADIIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIV2</accession>
    <name>A0A6A8FIV2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">gatE</name>
        <name evidence="8" type="ORF">FIO04_02145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000075">
        <property type="protein sequence ID" value="MRN68479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="7">
        <location>
            <begin position="486"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN68479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="647" mass="71650" checksum="CD1FA4170627E008" modified="2020-06-17" version="1">MTIDPVVINLKVGIEIHQQLATSGKLFCSCRSKEIEKYGATFVRKLRPTQSELGSYDPAALFEFKKMRTIKYYASVTSSCLVEADEEPPHDVDNGSLETALIISLALHSDIGDELHVMRKFVIDGSNTGGFQRTILVANGGYLDVNEKRVKVQSICLEEDAAKLISDDGTIKEYGLDRLGVPLVEIALEPVTGTPEEIMRIALSLGRLLRASKRVARGLGSIRQDVNISIDNGAVVEVKGVQRLDQLVKVIQYEMLRQHGLITIAQKLRDRKDVEKEIGDRIEDVTDILMKSPSKVVINSLQENNSIFKAIRVRGFGGMIGFEPYPDIRLGKQLSELVRFYGLGGVFHSDELPRYGISSEEVQAIKNKLRMDAEMDAFVLVGGQNFKVDLAIEAIIQRLKMALNGVPPETRAATFEGKTVFSRPRPGAARMYPETDVPSIPINSSRIASLSENVPKSMDEILNSLAKKYSLNKKLAEQIFDSDYFGIFEEIAGSVKEVRPTFIASKLTEDLINLERRGLDPAVITDEILIDVFKRLDNGTIAKESVISIFEKLMKKEAETVEEAKMALGITAISDQELDTAIEKILKENMSIIIEKRLGAVGILMGKSMALLRGRADGHKINSMLQQKLEYLLMKVNSSDDSPSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIX6</accession>
    <name>A0A6A8FIX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000196">
        <property type="protein sequence ID" value="MRN68866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="245" mass="27812" checksum="A56F17BED42AEEF5" modified="2020-06-17" version="1">MFRVKKVYIYHDKTTNIAKEDLSLLKTVLRYLDTPQYLRKLLYPLSDKLEYAGLLHPINAPHHRELERIRDVKFGDVRVGVILKVGGKLHADVGLSSLVSFEGSGFHGKKVNVKIVSTHPSLKGKEATDYDMKDKYWGYEIQETYSLNKLLESTSNTQIIITSKKGGYVKDKEAKILAFLKSFSNLLIVFGTPKKGVDEILASEGRRIDAFEFVLNMFPFQGTKTIRLEEAILGSLAIFNHFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIZ1</accession>
    <name>A0A6A8FIZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000352">
        <property type="protein sequence ID" value="MRN69211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="171" mass="18568" checksum="CCDC0B809EA5AB09" modified="2020-06-17" version="1">METEETGRAKKGLASATEETRVRVAREGGVAPHNRRGLAAANTETRLRVAKAGGDARSHDSDSLRDAGRKGGESVKAEYGVEFYQTIGEKGGESVKQKYGVDFYREIGEKGGGVVKEKYGPKFYSEIGKRGGEIVREGRGIANYSTKGRKDFEDEEKDKVNNNDLSSSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ02</accession>
    <name>A0A6A8FJ02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000369">
        <property type="protein sequence ID" value="MRN69244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="393" mass="43457" checksum="C736EC671EB5007D" modified="2020-06-17" version="1">MTSVFNALSFPLVIITIIIIVGVGLILSLSSNPLYGVKNYLFPSFVLTTNEANSLSPTSAFALSESPKLSQLIFHVQEFTIPGNNDSIPLYPLYDKNRNAIWVGDTAIDSSRILAFNLKSGKFMEHKLNGTSIVTVMAFDHNNTHIWYVDPLLKRLGHYDPSANTTKLYNIPTNGTISRIAIDLKNNVWLTSPNTNELLRFNTREKNFTVLNLPTTNAMPIGIAVDKSSGMIWVAEGIGKLASIDPIKNYKINEYPVLAANNSNHNNNTHYTPTELFIGPSASDDIYISEHDNHTVSIFNIISKTFKTYPVFNPKALPFGMAMDMSGYLWVAEHTTNKIAVIDPKTGSSREVVIPKPNPYVQFLTSDSQGNIWFAEQLGNSLGVITSSPIKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ46</accession>
    <name>A0A6A8FJ46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Queuine tRNA-ribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000398">
        <property type="protein sequence ID" value="MRN69294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="164" mass="18546" checksum="3442813E30F06893" modified="2020-06-17" version="1">MKPLPLNPEEKIRHHIDALFGTGIYNILTIHHSTKDFSFEYSRRTGRIKNFSIKNQLVATLRTDGGLALTIFGATEFLGNERFRENCVIPTEEALPFVRQGRSLFCKHVEWCGSNVKVGSDVAIVDEWRVVAVGRALIGCNHMKNYHKGIAVKVREGIKSPREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ64</accession>
    <name>A0A6A8FJ64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000408">
        <property type="protein sequence ID" value="MRN69314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="132" mass="15000" checksum="51439A6BF5193F20" modified="2020-06-17" version="1">MDNNEDLKNTSPQNVIRLIDSFIEQMRQTRKTMALCLSLSISSIVVAPVAIGLSIFLLQHPSFFAILERENEFGLVLAVFLIGVIILSSVCLVVGIKQYRSINSWNKKYSVYSKKKEELDRNIASEYDLDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ73</accession>
    <name>A0A6A8FJ73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000414">
        <property type="protein sequence ID" value="MRN69324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="83" mass="9709" checksum="8A8AF9603E728574" modified="2020-06-17" version="1">MNKRIAGDPTILTDCFAQHIACHQQDQFFEIFQPLREYHLPVSLRRKLEGRMILLGFNVRGSSALPYESTLAAFFMWMKKFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ79</accession>
    <name>A0A6A8FJ79_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000235">
        <property type="protein sequence ID" value="MRN68966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="85"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="232" mass="25264" checksum="28928B8BB6BECE30" modified="2020-06-17" version="1" fragment="single">MGARILSIVNNPTSSLARISDSSLSIDCGPEIGVAATKSFTAQLSLIYTIVDRLCNGCLDFEANKAFLVGALRQVLDTENQIHSIAEGLRDARDIYIIGRSIHYAIALEGALKIKELAYVHTEGIAAGELKHGPLALIDRNSYVLLVNPDDIASEDNIASAYEIKARGAKIIGISDRPNNVYDIFIKIPSVKSTFYPIIEVLPFQILAYYLALAKNADPDYPRNLAKSVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ99</accession>
    <name>A0A6A8FJ99_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_01095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000033">
        <property type="protein sequence ID" value="MRN68277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="4">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="323" mass="35896" checksum="7D431AD28792A499" modified="2020-06-17" version="1">MCRTAVFYGDALARYGFENPHPWRSDRIFAFWSKFQNENLDKSSQIVIKDPVSADEESILTFHERDYVDLVKKSSKTGSGFLDMGDTPAFQGIFEASSFVVGTTLECLNLLMKKQHEVQHVFNPIGGLHHARRDSAAGFCVFNDIGVAILIARKRYGLKRIAYIDIDAHHGDGIYYEFENDPLLFMADIHEDGRFLYPGTGSELETGIGEAEGTKLNIPLAPNSIDKDFIIAFNKIENFINNVAKPELIILQCGADSLNGDPLAHLKYTPNAHRYATDVIHGLAHKHCMGRLIALGGGGYNRANIASAWTEVVKSLIAEPQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA5</accession>
    <name>A0A6A8FJA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000006">
        <property type="protein sequence ID" value="MRN68120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="346" mass="39275" checksum="07057BA8B19AF324" modified="2020-06-17" version="1">MKNRWLAASHIKKTNHIKKFRKLLLLNFECVLFDVDGCLVDIRKSYNAAIKKTVDFILNYVVTTAAIDNFRLTNLVSDNIILKFRQTGGFNNDVDTSYAICLAELANPHKNVTNAREFLNKVAANSDEDGIISVEKYLISLTSSTIIKNLKKLLDYPASAGKRSVIATVFDELFYGPELFKKLHNFEPKFYFGKPLIENDRLVITRRTMDLLARRFSGNLAVVSGRSKLAAEYSLQPILDTLKQDSSVFLEDERREYAKPNPYGIMKAMKSMGTKTAIYAGDSYEDLIMVRRAEEKTHLKIAFCGIYGCSSQPLETMRQFKEKGADVIIQNINQLPKILNKVSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJB2</accession>
    <name>A0A6A8FJB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_00595</name>
        <name evidence="2" type="ORF">FIO04_06485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000009">
        <property type="protein sequence ID" value="MRN60541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000419">
        <property type="protein sequence ID" value="MRN69331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN60541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="130" mass="14600" checksum="1FC2C5983A1752B1" modified="2020-06-17" version="1">MYKILENLATDGLGEPSELSGYVDCEIGLIDDFRIIDVRVLPEFDAPSSPSEYKLNIMRVASYLELGEKVVVCCSHGMNRSNAIALGVLVQYFKMDFFKAWELIQSRVPTCTIISTNIVALTKLFKVKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJC2</accession>
    <name>A0A6A8FJC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000425">
        <property type="protein sequence ID" value="MRN69341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="180"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="280" mass="31230" checksum="F8A690F0B43A0E7B" modified="2020-06-17" version="1" fragment="single">MSSNTIEEFIHRSYVSKPKYIEVMAGVPEDYSQIKTLGDLLGINYKHVTVERQLRGNLITKLKNHEYPYPGIIGYNEDVIPAVNRAILAGHDILFVGQIGQAKTKIAECIAESLLSLVPVVEGSITNDIPTSIPEEQMINILNDAEVVRTSPEFTVSKECEEIIRNNKLETKINWIDGSQRYRYILATPDISVKDLVGQIDAIKIAKKGVELYDIESYSSGQLLQARHGILCIDELPVLDPRKQVALLSVLQEGKFTTGSYPVVFKPDVKIMATANPVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD0</accession>
    <name>A0A6A8FJD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000009">
        <property type="protein sequence ID" value="MRN68140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="181" mass="20989" checksum="CC3B5472AFBD05D2" modified="2020-06-17" version="1">MELQTEPTDSYTDSRHHSKALILKQIDKSPGIRYRELLRLTGLTNGGLEYHLKILEKSHKVKVDRHDGRRTRYYPLNISADESHILGCVRNNVSRQIVSFILEHDLCTFGEIVEHIKKAPSTSSWHLKRLSDGGIISITYGQEYQLYSIVNNNLVKAVLYKYEESFRDKIANGYYQMFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE3</accession>
    <name>A0A6A8FJE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000107">
        <property type="protein sequence ID" value="MRN68593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="228"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="375" mass="42586" checksum="214D255B0945DC5D" modified="2020-06-17" version="1">MLFFTSPIGLGHATRDIAIAEKLKQIVNDEILFISGGAAYDLISKEGFQALNLYRPPSFTVESGKLRNPFVWLMKYIIYYKRCKKIAEEVIRKVSHKYPVIVSDEDFASIAVSQNTILSKNILIYDMVEPTANTINDKASRYGITSTYGNIKFENNIGETHFTSGFLHEIEKKMNRSMRHLINKCDNVIIPDFGDNKANLVYVGPIVREIKSERKSLRYNFGLTRKTILVCAGGTDAGRHLIQKSLEAYRKLKNRFDVDLILVSGPNLKLDDSNDFYNLGFVDNLHEYVYASDLVISLAGRSTIDESTVYGTPGIFIPIKNHFEQEQNALRLGYKYEDISKLERLIQEKLELSHQNPILNSRGAEVTAKIISELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJE8</accession>
    <name>A0A6A8FJE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="123" mass="13389" checksum="E23432CE31017C4D" modified="2020-06-17" version="1">MRVFFTGTSWNSVEGRESFGALPYIIGALVSPAIAIVIGGPVSLGIAIFGSELSSPKISTPLSFVIELLAAVQSIIDALWALLVFRFWSVGLIERPLYKAFGGSIPFFCKRPFQIRPTKQVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJH9</accession>
    <name>A0A6A8FJH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannosyl-3-phosphoglycerate synthase</fullName>
            <ecNumber evidence="2">2.4.1.217</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_01515</name>
        <name evidence="2" type="ORF">FIO04_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.217" evidence="2"/>
    <dbReference type="EMBL" id="WJXD01000029">
        <property type="protein sequence ID" value="MRN60721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000019">
        <property type="protein sequence ID" value="MRN68190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050504">
        <property type="term" value="F:mannosyl-3-phosphoglycerate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012812">
        <property type="entry name" value="Osmo_MPG_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09488">
        <property type="entry name" value="Osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02460">
        <property type="entry name" value="osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN60721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="394" mass="44371" checksum="E4402149B5C3A6AD" modified="2020-06-17" version="1">MKLDVPRYTERFGAISLHGVQRVYELDSGFNDGRPASEAIRSVGNVEISEIERKMAIVIPIKGERLKLLEGVLSGIPHDCLTIIVSNSPRQPVDRFKLEKEALEQFNRFVGKNTLILHQKDPGLSDALKEVGYTSIFGPDDIVRNGKAEGMVTGMLLAKMAGKEYVGFIDADNYVPGAVNEYVKIFASGIAMSNTPYTMVRISWIYKPKVSESGLYFSKWGRVSEITNQYLNSLVSYYTGFETEVMRTGNSGEHCMSMKLAELLTYSSGFSVEPYEVVNILEEFGGILPTENQDAMDKGIEVMQVETRNPHFHEEKGEDHLKEMFNGSLGSIYHSKICPPRLRDKISEELRGREIIQEGREPDLLKNINSFKNVDMHQFAKILHDRAISFVHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJI6</accession>
    <name>A0A6A8FJI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000020">
        <property type="protein sequence ID" value="MRN68200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="179" mass="20733" checksum="16BA707F5141F2FA" modified="2020-06-17" version="1">MNILIAEDEEDIALLYKKVLEARNHKVTVTSNGEDCLKSYHDVFQEVISSDTRSIQRFQLPFDVVLLDYKMPQINGMEVAKEILAVNSHQRIIFASAHIKEILENSIKQLKQVVELMQKPFSINKLIDTIEDKEVYNELQKLNVDIDIVKAFIPTHQQITDLLERLRKIQKNSSNAVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN0</accession>
    <name>A0A6A8FJN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_00900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000026">
        <property type="protein sequence ID" value="MRN68240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="59" mass="6311" checksum="17668FA7EA4DD6FE" modified="2020-06-17" version="1">MATIYIKWKVVLGSLAHDHSDGNTGNSGKQRRVGKKGIFLTAAIVAGIILASFLVYIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN5</accession>
    <name>A0A6A8FJN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000134">
        <property type="protein sequence ID" value="MRN68683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="71" mass="7976" checksum="21205185E740B7D0" modified="2020-06-17" version="1">MSHRQASVNGYESKKEWSAVQHVESYLNIVNDIPHRSEGILLEYVPLNAKRILDLGTGDGHLVYLIRGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ9</accession>
    <name>A0A6A8FJQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000145">
        <property type="protein sequence ID" value="MRN68713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="80" mass="9370" checksum="709CD7BFBEC6908A" modified="2020-06-17" version="1">MTCKGICSRHKAMKPVGTGRYSTGQKRCQVCEIFLKWDGLWCPCCGYRLRTKPRNLKYKAKLRSRKEIEKSRVLLTSSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR4</accession>
    <name>A0A6A8FJR4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ORF">FIO02_01075</name>
        <name evidence="9" type="ORF">FIO03_01180</name>
        <name evidence="10" type="ORF">FIO04_05090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
            <strain evidence="8">AHI_AL_Thaum02</strain>
            <strain evidence="9">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000008">
        <property type="protein sequence ID" value="MRN39627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000020">
        <property type="protein sequence ID" value="MRN60654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000278">
        <property type="protein sequence ID" value="MRN69058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN39627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN60654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN69058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="62" mass="7167" checksum="CDFC15143AF75B17" modified="2020-06-17" version="1">MKGEVAVYKFYVIEGNSVTRNKRDCPRCGKGVFMAEHRDRYSCGKCGFTEFTEHSKKATKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJR6</accession>
    <name>A0A6A8FJR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000328">
        <property type="protein sequence ID" value="MRN69166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="261" mass="28945" checksum="2A1980DAF5AC29AE" modified="2020-06-17" version="1" fragment="single">QAFQFGAQVIQVDGNFDDALAASLAEVTERQGYTVNSVNPFRLEGQKAIVYRVMEHLSWNPPDWIVYPGGALGNTSSCGKCLIELHGWGWIKKIPRIAVINAEGANSFYELVNGLFENKTLDWNNGRPDLEMVDRYYLHKQNQGVLPKTRATAIQIGKPANLVKALRAIDITKGVVTQVNDKDMSDGMSIVGLNGFDCEMASGAVPAGVRKLRLEGIIKPDDVVVGILTGRQKDPKLPVEYHNNRSNRYARPAREINNHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS6</accession>
    <name>A0A6A8FJS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000074">
        <property type="protein sequence ID" value="MRN68477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="349" mass="39538" checksum="27185A7C0E2FB461" modified="2020-06-17" version="1">MQNNSFEYEYRESLKSLADDKKITQNQLDHFIRRGIQSISPTDDFDLKSLGKMLPRIVIGASDDYINRMKVPYQATSYIAANTKAPDDSYIYKIPGKNAGGVVQLSGGKRKSGDNAFASINRILIGYKAIMVSAVNLMANKNQIWNWQFFGNHFKESNLDIYEDLLKLELIKKRSKNFYYIVIARSDKTFKRVNLLEEYRKNEIAVLNPNNKIKVIFVTSQSGYDYAVKTIPESDLVNYIITGEEFVIYKAMLTLRKKYSVDIMLNDGGRIMSNGVRDAGLLGEERVTLEPYPGNGLIPNEIDPSSILGKKGIGLDENEVEGTILIHSNEIGDEKANVYLYPLDEQKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJT2</accession>
    <name>A0A6A8FJT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_01160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000035">
        <property type="protein sequence ID" value="MRN68290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="238" mass="26671" checksum="56C5A93592ADF903" modified="2020-06-17" version="1" fragment="single">MNSTEYYTQCPECESGLIHDYNIGEYICQKCGYVVMDQVDDYGPESNSSDFEERSKNTRASGYTSLSLHDYGLRTEIGFGSKDYSGKSIDCQMAEQMNSMRKWHSRIRVASPKQRRLSNVLSRINETCSAMCFPKILVETAAMIYRNFESRSGAKGKSINSMAAATIYLACKRCSVVRSLEEIVEATGITQKDRSSLKLSSKYYRMMVMEMGVFTVQPTQLSTSLSSHFPALAEAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJT4</accession>
    <name>A0A6A8FJT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000286">
        <property type="protein sequence ID" value="MRN69078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="173"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="261" mass="27925" checksum="FEDFF6E6D6B84008" modified="2020-06-17" version="1" fragment="single">IVRKLDELEVSFSNGKSFPANVIGNDPYSDIALLKIQANDKNDSISLIPIEIGDSENLKAGQFVLALANPYGEYPSITEGIITSERSSLGGGRWGGITNNIVITDARLNPGYSGGPLVDVEGKMIGLNAAYVSSRGIAIRASKVRNITDQLAKYGAIKIAYLGVVTDEISLPREVGAQLEPSQEEGLMVLSVEKDTPAKKAGLLLGDIIIGFDDQPIANIHDLRRQLLNQDVIGKSVKLAIIRGEKKSEITITPRESSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJW4</accession>
    <name>A0A6A8FJW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3311 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_07235</name>
        <name evidence="3" type="ORF">FIO04_03645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000134">
        <property type="protein sequence ID" value="MRN40819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000165">
        <property type="protein sequence ID" value="MRN68773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN40819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="75" mass="8879" checksum="1EDCF17D5FB479DC" modified="2020-06-17" version="1">MKTKLRYVILALLILIPSIINLLTPLYNRRLPEFFGMPFFYWFQTVWLALCSGFYLGFARLMNGGKNKEEETVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJW7</accession>
    <name>A0A6A8FJW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000298">
        <property type="protein sequence ID" value="MRN69102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="190" mass="21889" checksum="C53A34071DC7F5B5" modified="2020-06-17" version="1">MAYKKSIVISGWPAVGKTTVACELAKEFGLKIFNGGDILKKLAGEKGYLISGKDWWDGEEAKKFMAERRTNPFFDKEVDQKLMEIAEMGNAVITSYTLPWLTENPIKFWLRGSQNNRAKRMANRDNINFLDAKKIVRLRDDDTKKIYRKLYKIKFGDDLTVFDFSLNTDLLNLLSLIAISKNMIRHVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJX3</accession>
    <name>A0A6A8FJX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000355">
        <property type="protein sequence ID" value="MRN69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="244" mass="27204" checksum="8AB39F2FED559F8E" modified="2020-06-17" version="1">MPYNTDAPPSRTRKSAVCIVSGGLDSICAAAHLKEEGYTIYMLTFVYGQRARHEVQAAKQFARILNTDDHRIIDIAFMKEIYGRTNALTDTTQNLPEHFDYSIVVPLRNAVFITIATAWAMSIGAQLVAYGAHIGDKQYPDCRPTFIKSITKTLNLAEADGIRLGLRRKITVWSPAVNGIDKSELLSKGYRILGDKIFDTWSCYSNGVKDKGKNRMHCGKCESCINRKIAISKVSIEDKTSYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJY0</accession>
    <name>A0A6A8FJY0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000311">
        <property type="protein sequence ID" value="MRN69128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="62" mass="6638" checksum="3E4FB3AC12BE225A" modified="2020-06-17" version="1">MNSCDGVAPFGHGNFPFPQSASGRVLARIAGRHGRTPRQVALNFLARHPCISRLPTPAGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJY2</accession>
    <name>A0A6A8FJY2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3734 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000171">
        <property type="protein sequence ID" value="MRN68793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021095">
        <property type="entry name" value="DUF3734"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12536">
        <property type="entry name" value="DUF3734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3734" evidence="1">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="91" mass="10810" checksum="C44E5884E9975544" modified="2020-06-17" version="1">MHEFVIRSIHSNDNRYVNNDNKLNKEKFTKIEEEYDKLAHQRGAIIREIVRIERAEESRSLFEDADFSDETIKKSIMQGERDAEKALVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK26</accession>
    <name>A0A6A8FK26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000098">
        <property type="protein sequence ID" value="MRN68567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="135" mass="15544" checksum="1A82A53EE2D1D2E9" modified="2020-06-17" version="1">MSSKSKDNDGDNSIKDTEKEHNKTSVVELLDALISHMNAIRSVFKVMILSSFILAPLSLMFAAVLVIHPFFIQRILFRFPDVGVFLLFFIGVSIMLASMWLYIGLSEQRFFSNWDKKFSRYTSLKNQLDKELGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK36</accession>
    <name>A0A6A8FK36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000190">
        <property type="protein sequence ID" value="MRN68853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="328" mass="37381" checksum="27EA2B5D8BF85DF0" modified="2020-06-17" version="1">MRKNMRAKTSGKSPITASKKDGEDNSYTALTNALIYSLDILKVKEETEVGREIAQLAVKRLPQNGISGGKWLTVTKTIADICGENDRHIFSQSELYDFLTLATKQMDKKHGKVFASSDIVFKIYRDIMENYQSADKSLKANYPKIIVDMVSVLMDGRDTVGREVSAHSMERYYQARKSEIWPPKRDSSKYIGIVEKDYDLIESLSQITGRKRSDLIESLSKVEIADVGKLTDLCLNYNKLQKYSSLISSEGEFKKEVENELGRRLTYNQLQHASVSVRKSRDYIENVLDGKFVPHGSHGINHVRHNLEYGYQLMGLIERKKRGSQKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK43</accession>
    <name>A0A6A8FK43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_01510</name>
        <name evidence="6" type="ORF">FIO03_07710</name>
        <name evidence="7" type="ORF">FIO04_01840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000013">
        <property type="protein sequence ID" value="MRN39712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000319">
        <property type="protein sequence ID" value="MRN61909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000060">
        <property type="protein sequence ID" value="MRN68420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN39712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="171" mass="19411" checksum="351272E35198808B" modified="2020-06-17" version="1">MQFDYELLDDVNLKILDKLGEDSSTPFVEIAKQIGVSDATIHIRVRRMVDAGIINKFTLSVDNDRLGYDHLAFMGINTEPGSVESVILDLCLVDEVLEVHEMHGTFDLILKIRAKNLEQMRDIVENKIRTLPHILETELMPVLKSRKEEQIVSLKKDIATKAESAERAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK97</accession>
    <name>A0A6A8FK97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000377">
        <property type="protein sequence ID" value="MRN69258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="101" mass="11115" checksum="D00CDB7F7F51E7DB" modified="2020-06-17" version="1" fragment="single">EDSSAENAKRIKRRLEIISDKLREMSLRFVRPDGAMYVYPELGIGKSDVEFVQKALDLGVAVAPGSGFGDCYAQFIRISACQPDDQLEKGLELLKAAMSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC1</accession>
    <name>A0A6A8FKC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000241">
        <property type="protein sequence ID" value="MRN68979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="365"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="618"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="739" mass="84590" checksum="A6869B17DEFEC021" modified="2020-06-17" version="1" fragment="single">QYVFDSFWSRAIPAERRIREIEEGIVQYETKVLENKEQIFSHMKSVIEKASERSVCSSIGGMQLVYNYFFDEYKKIIDRHRKRGEGKGVRWIISIDKDSIDLVKLFLNTGVQIRHVKNLTPMNFAVDNRHFHATIDKMEAGKIMESLLTSNEPAYISHYNSIFEHLWKNGTDAVGRIKEIEEGVDLADIEVIPSSARAQGIYLDIVKAAKEEILWIFPTTNAFIRQDKIGAIPLAIQAARERNVIVRILVPGNSLIEEKVQQLKQYCSDHIIIDVRYIEQMSETKATILVVDRKDSLVMELRDDSKTTFFEAIGLSTYSNSKAGVLSYVAIFENSWRQAELYGQLMKVHEQLKIHDKMQKEFIGIAAHELRNPIQPILGLAEIVKSKIKDAKQCEFLDVIIRNAKRLKRLTEDILDVTKIESQSLDLKKEQFNLNDVITNAMNDIMTNIDFLRKSQRNAIKLLYHQPQDIFIQADKGRITQVIFNLLSNAVKSTEEGTISVSLEKKEDNDHVVISIKDTGTGIDPGILPRLFTRFATKSFAGTGLGLYISKSIVEAHGGKIGAENNSDGRGATFAFSLPLIIQQDRRQESMAINTTTAATMISDIEERIKFHKTKMKRIFLVDDDYDHTITFKVGLELAGFEVDAYNDSAIALSNFKPDYYDLLLIDIKMPKIDGFELYERIRKIDDKVKVWFITAYEVYYKTLTEVSSKSKEETILDRFIQKPIEINNLVKQIKSELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKC2</accession>
    <name>A0A6A8FKC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000226">
        <property type="protein sequence ID" value="MRN68943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="53" mass="6205" checksum="6EAC33D4B2ACA27B" modified="2020-06-17" version="1">MKIRKPTTGLCFERTSASVDIQHTNEKHEQMRWTMRLLGRIVNKSFDNITGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKJ6</accession>
    <name>A0A6A8FKJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000426">
        <property type="protein sequence ID" value="MRN69342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="140" mass="15505" checksum="58AA47BC4C4995AE" modified="2020-06-17" version="1" fragment="single">MSILHISARIGEKAPNLAIAEWIQGRSTNIDKEMGNVVLVEVFQVNCPGCFTNGIPQAIDLHIKYYHDGLRVLGVATAFEDFDKNTLDNLKLLLTSGEVIGETSKVLAEYGRLRPGNKLSYKIPFPIGMDTLLKYSKLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKL1</accession>
    <name>A0A6A8FKL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000278">
        <property type="protein sequence ID" value="MRN69059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="234" mass="26977" checksum="E339CC34343A7404" modified="2020-06-17" version="1">MVLDPLRLIEDARGSARIPEKIYRRIEERFHIVMDGINRIEHASGLKYPYYYVLPELVLVSSSVEYDQVGVFFARTIPTIGFNNRLQVVIQITAPLVAYGLLGTVHAILAHEFLHYLELVRRIIKMNIVSHEISTTLFEDKYSDDERLMNARVVFSSDPTLIRHISNRFNDGFRDPRLEKIAINEWIDKGLPVTNVRIDCNIIRIPFESMVSLEVDDVVKEKIAAYETASRATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKM5</accession>
    <name>A0A6A8FKM5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDPG_MGDP_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_05195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000287">
        <property type="protein sequence ID" value="MRN69079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="118" mass="13314" checksum="C17FC755A0EB1A9C" modified="2020-06-17" version="1" fragment="single">LYLYCQANNINFPELRDALNTKWNVNILEPREGVGGHCLPKDTKMFLHSSKSIRSKILTASMEVDQHYRRYRQTRGGNNNNCGNSTQLRAEVIRDDFLSSPPSSLSPINAAEDTEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKP4</accession>
    <name>A0A6A8FKP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase HflX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hflX</name>
        <name evidence="6" type="ORF">FIO04_05265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000294">
        <property type="protein sequence ID" value="MRN69093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="5">
        <location>
            <begin position="187"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="270" mass="30365" checksum="AD5287041F329777" modified="2020-06-17" version="1" fragment="single">MSNSHKAILITYPFEDAAKEAISLADAAGYSIERVVNQHHITRSRYGIGIGKAQEVKQLVEQEKPEVIIFDEVLKPSQQYNLASICQVEIIDRERLILKIFDRRASTAESRIQIKLAQLRYDMIRAREKVRLARAGEQPGFFGMGKYDADVYFLDIKKRATVLKKKLQKEEVRRNLHRIQRSKAGLPTVSIAGYTAAGKTTLFNSLTGESKITGQGMFTTLSTFTRLVQSKGTKLLISDTVGFISRLPAYMVDAFKSTLQELSYSAVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKQ9</accession>
    <name>A0A6A8FKQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000303">
        <property type="protein sequence ID" value="MRN69113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="108" mass="11866" checksum="5817C3034380EA2D" modified="2020-06-17" version="1">MSSVNKQFFINQLVWIGISFGISIMISMLIPFPISLVAVVGTFLLLNFYLRRRMIARMGSVKGTIMGGMFSPTSADGGSLKYYCMNCGMQHKQAACPVCGSKMKRIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKS9</accession>
    <name>A0A6A8FKS9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000535">
        <property type="protein sequence ID" value="MRN69506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="93" mass="10414" checksum="C97093659F51F5E3" modified="2020-06-17" version="1">MKPGVDIQLLQSVRHKLIAKNITLQSIKQRQTTTTLVNQLDIPEGLKELIISHGFTLDLLLGLQPIDLAQTLGIDNDVAKMIINATRRLVKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKU2</accession>
    <name>A0A6A8FKU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000316">
        <property type="protein sequence ID" value="MRN69139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="107" mass="11746" checksum="049A8B8BC10D994D" modified="2020-06-17" version="1">MTINDFAVACAVDDSTAYFTYEGETMLIIQSKGHAKSGRNDFEVIQPFVEALISHESVHVVIKKLEGANISDSLDDIEIIVERDGVKFQVTLNNILFAQDTSGIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKU7</accession>
    <name>A0A6A8FKU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000322">
        <property type="protein sequence ID" value="MRN69153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="143" mass="16378" checksum="E15F55E963660E21" modified="2020-06-17" version="1">MADILHKIDIEAIPDKVYSAVSSNHGLKSWWTTDVSGDSKKGSVLNFGFYNHSFTFEMYVDELIPDNTVRWKCIGGVAADEWKDTKLLWEIIPKDGNQTTLRFSHTGWPSTGDYYSRCNTTWGHLVFLLKDYAERGTVNPYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKX9</accession>
    <name>A0A6A8FKX9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RECA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_07160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000505">
        <property type="protein sequence ID" value="MRN69462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="247" mass="27354" checksum="34E2469654CEEA02" modified="2020-06-17" version="1" fragment="single">MFHQYSTEKPMLHVLPTGCKAIDNLLGGGIHYGMVTDIYGESGTGKSQLCFTICARSAEYFETSQQVSVVFIDTGGTFRPERITEIAGMTKMKTDILDKILVVRSLSSTDQINSINRLSQINPRLLIIDGVASLFTADYRGAARHLALMKHLHELSVAAINLRCAVVMTNMVRTAITAGNQVKTSIIMVENPNRSKTQQSDQQRELMGTSVSIYAHMKLMLKATNLEKSIFKAVLLQPSSKQEAYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKY6</accession>
    <name>A0A6A8FKY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_03260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000140">
        <property type="protein sequence ID" value="MRN68700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="282" mass="31461" checksum="14CF4E15E36C3B95" modified="2020-06-17" version="1">MKRERITKLQPRKYSIEEKIRRKKISRINLNDIANTILFLAVFVGIWQLTFMLGIWPRVALPSPAMVAQSFAELNFSLITNISVTMWRLMIGFSISIILGVGIGLAMVKFKDFGKTMSSFAVGLQSFPSIAWVPFAILFIGLNDFGILFVVIMSSIFSVMLSTYSGIRTVPPIYARAARNLGAKGMPLFRYVMIPAATPSLIVGVTQAWSFAWHALIGAEILMAAYLGLGHILDVGREFQLMDQIIASMITIFAIGLVFDRLVFSKLANKVRDRWGLNQGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKY7</accession>
    <name>A0A6A8FKY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_00490</name>
        <name evidence="2" type="ORF">FIO03_05830</name>
        <name evidence="3" type="ORF">FIO04_07350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000003">
        <property type="protein sequence ID" value="MRN39512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000202">
        <property type="protein sequence ID" value="MRN61555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000529">
        <property type="protein sequence ID" value="MRN69498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN39512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="57" mass="6447" checksum="4E3D3A3FF9BD6593" modified="2020-06-17" version="1">MRTLRIEEITYKRLTSVLEDVMHYKKKDVNYDDILNELIDVYQENVGGSIGGTVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL00</accession>
    <name>A0A6A8FL00_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">thiL</name>
        <name evidence="3" type="ORF">FIO04_03370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000147">
        <property type="protein sequence ID" value="MRN68720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="336" mass="36628" checksum="620934DC43437E66" modified="2020-06-17" version="1">MSVLNERAIIDIIISNLGLRGNNKRRDDDVSTVSLRNMKRMKSLIIKCDMLIESTDVPPGMYPWQIARKSISACVSDLSAKGIKPQVSVISVGIPKKYSKTEIEDLAKGFQIASKEFGVKIVGGDTNESKELIIDCSMIGFSEDCASGLPGRNGAKPGDLVVVSGEFGYTSSGLKILTKNAKAYGEFKNNAISSVMKPKPAQKFGISLAKYFSASMDSSDGLSISLYELARQSNVNFLIDNIPSAKGVCNFARNNQLDYKRLIFCGGEEYEIVGTSAPANLKKAKATARRLKLKLFIIGKVEKGEGKVFLLDRKTGKRVQLEDIGYVHLNHRGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL24</accession>
    <name>A0A6A8FL24_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">grpE</name>
        <name evidence="6" type="ORF">FIO04_03470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000154">
        <property type="protein sequence ID" value="MRN68740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="208" mass="23959" checksum="9A5922324C55223A" modified="2020-06-17" version="1">MEEEFNGVEQVQQNESRIERDDILTMKDELVAAKEELSFVKEELRKAKESSDNNLNKLKYMVADFDNYRKQMDKQVASKIEESKAELMLRFLNIRDDYVRAVEIAKQSKAELVVVEGLEGILKNFDHLLKSEGVIDIETLETPFDPNVHDAISFSYHDDLPESTVTDEIRKGYMLDNKVLRPSLVEISKKIVKNTVNDTEKAEKGTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL47</accession>
    <name>A0A6A8FL47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000206">
        <property type="protein sequence ID" value="MRN68897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="83" mass="9468" checksum="C5C91BC6DE9D88E4" modified="2020-06-17" version="1" fragment="single">MRKPDYAINRQEFLSFLEKEAKLRIDGFIEGAIEVAEEVHHGVTREDAVSLFLETHTWPVAIDVVKHYRSVNRTITSVEVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL58</accession>
    <name>A0A6A8FL58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000373">
        <property type="protein sequence ID" value="MRN69249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="180" mass="20865" checksum="5154EF958818FBEC" modified="2020-06-17" version="1" fragment="single">MKVRCEWAANGSPIDIEYHDNEWGVPVHDDKKLFEFLLLESAQAGLSWTTILKKREGYKKAFDNFDADEVANYDPRRLRQLLTNPSIIRNRLKIQSAVKNARAFIKVQKEFGRFDSYLWNFVGGKPKHNEWKSWIEVPSRTEISDDLSKDLKKRGFTFVGSTICYSLMQAVGMVNDHTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLU7</accession>
    <name>A0A6A8FLU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000533">
        <property type="protein sequence ID" value="MRN69503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="142" mass="16266" checksum="FEB4FF8ED6A997DD" modified="2020-06-17" version="1">MVNNAGYAFACPFEDLSMDEIKAQFETNFYGSVRVMQVVLPTMINQSYGRIVNESALGGRIAFPFDSASHATTFALEGLSESLHHEVEQFGIKIIPIEPDVVKSLFFDNLRWQNAQRSYSPYLDDAKNKCRIRFFIRKCYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLU8</accession>
    <name>A0A6A8FLU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000523">
        <property type="protein sequence ID" value="MRN69489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="97" mass="10257" checksum="A089B3BF50B4AA05" modified="2020-06-17" version="1">MLLLLVSIVQSVQLVNALNSTMSGGTSGNTTITTAGNKTVITTGTAVAPTTSPPNYNRTGFNNLYVLTINGKNFPIKYSINGGKLVSKQCECKNIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLY2</accession>
    <name>A0A6A8FLY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prs</name>
        <name evidence="3" type="ORF">FIO04_05050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000275">
        <property type="protein sequence ID" value="MRN69050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="305" mass="33359" checksum="4F9FFBA918850F74" modified="2020-06-17" version="1">MYKDVSIIAGPSSLDLATAIAKHLDAELVPVDLRIFPDGESKIKMRRVDKDYCIVVQSTYPPTDRHLLQALMMIKRCSEDGAANVCAVMPYMAYSRQDRAFLDGEVVSMALVAKLIETVGTKRLITVDIHSPASLSYFTIDTQNISAVGLLADYAAVKIKPNAPIVVSPDMGGAKRAVKFARMLGTDMVALKKSRNKDTAEVIIEEKELNSSVLGRDLILLDDMISTGESIVEACRFLRRYKPNKIYAICTHALLIGDATTRIKAAGVEEIISTNSVPGINAKVDLAPLITTKLKAIIDTKKHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLY4</accession>
    <name>A0A6A8FLY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_07455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000548">
        <property type="protein sequence ID" value="MRN69519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="207" mass="22540" checksum="500B2DF2A16FAE72" modified="2020-06-17" version="1" fragment="single">MEKRRQNIHSTQRITKLKSVLLLTSIYFVVQVIAALSTRSLALLADAGHMLADVAGLALVLFAINYARKAATLQHTYGFYRVEILAALLNGVVLILISVYILYEAYRRIFEPPEIQGLPMIIVAAIGLGVNFTGMRLLGSNGHFHGGSRLDNVHVDTAKEHEDLNVKSAYLEVLNDTLGAAGVIIAGVIILTTRFYLADPLISIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM25</accession>
    <name>A0A6A8FM25_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rio2_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000376">
        <property type="protein sequence ID" value="MRN69257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rio2_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="140" mass="15877" checksum="85ECF2D0A419B635" modified="2020-06-17" version="1" fragment="single">MSSVQIAANVVKNLEREDYKLLRVFASGLEHHETLTRHQLVGYSKLHGDIVDYRVKGLQEMNLINKNNRGFTILNAGLDTFALKILAEKNIISGIGKPIGVGKESDVYEAVTDRQEERAVKFFRIGRISFREVTKKRSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM62</accession>
    <name>A0A6A8FM62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_06305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000399">
        <property type="protein sequence ID" value="MRN69297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="3">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="227" mass="25227" checksum="CBE3D60E12942C1A" modified="2020-06-17" version="1" fragment="single">EFSSSSSAMPHKKNPDPLELLRAKAGTVSGNLLTMITIIKAIPSGYSRDMQEIKTSLWQASATTTQALKIMNYVVKSLIINKERMEQASSNSYAISFDLAELLAIKNGMSFRTAHKVMGLLVRKAISNNRQPLRMLREEDIREVLESLGSKLSAEEVLKDIKETAPQKSISSRQSLGSPNPMQEQTMVKLSRGRLSAYSKRIAKRKGLVDEALKNLTRMVNNCSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM77</accession>
    <name>A0A6A8FM77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000405">
        <property type="protein sequence ID" value="MRN69307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="87" mass="9983" checksum="DC159BDAF783486D" modified="2020-06-17" version="1">MKKTDAHLKQVNQNIHAKTPNGCEECLQIGSDWVHLRLCLSCGHVGCCDSSHNRYATKHFKTTGHPIIRSFQPGEDWEWCYVDNIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM93</accession>
    <name>A0A6A8FM93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2203 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000416">
        <property type="protein sequence ID" value="MRN69327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="141" mass="16346" checksum="291A89C70161F326" modified="2020-06-17" version="1">MFRIYTPQDANKALPEVKRRFNTILSQKNNVVALQEEVQKTLESGSSLERFIKKKQQLNGAVSSLYKSIEQLEDMGIMIKSVDDGLLDFPCMRFDEEVWLCWKLGETEIKFWHDREEGFMGRKPLAPKGFLTGEDDLADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMS7</accession>
    <name>A0A6A8FMS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybutyryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000425">
        <property type="protein sequence ID" value="MRN69340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="126" mass="14248" checksum="475C5E084F68E715" modified="2020-06-17" version="1" fragment="single">YEISRLAQDIAGGLMVTMPSEKDFRSPETGPLLEKYLKGRKGVSTENRVRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLEYKKRLAKNIANVIEGEANDLTQEQSEYFDRVFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMX2</accession>
    <name>A0A6A8FMX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_06740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000453">
        <property type="protein sequence ID" value="MRN69380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="5">
        <location>
            <begin position="51"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN69380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="201" mass="22374" checksum="8570124B02B3F7E0" modified="2020-06-17" version="1">MSGKEHVNILLFNKWVTDKIQIKDLGLQKVISLKPAVIPSTSGRHVRQRFKKADVNIVERLANKMMHFGKRYAKNTGRMGGKKAKMLTVIRTALDIIHLQTGKNPVELLVSAIENASPNEDTTRIVYGGVVYHVSVDVAPLRRVDLALRFIAEGVRESSHSNPQTIDEALAKEIVSAATNDMSSHAIKKKNEQERIAMASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFP3</accession>
    <name>A0A6A8FFP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000001">
        <property type="protein sequence ID" value="MRN68074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="196" mass="21946" checksum="D9B7DC8B6A7A871A" modified="2020-06-17" version="1">MEKATSIVNNQLARLRLLDEKFSRMDKNFKHQIVLNIKSGNNSRAKALAGELSNIRNVQRTTQNAGLALEVMLIRFSTVNEFAMVLETINPTIGMIRDIQRDISKVIPAASSVFSEMQTMTSEVLVNSDIKLDVGSKFSTPVDKDALSILNEIEGILENEAKTKLPEVPSAILDKRMDKQFYEEEVSDKSQIMIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFR0</accession>
    <name>A0A6A8FFR0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="6" type="ORF">FIO04_00295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000006">
        <property type="protein sequence ID" value="MRN68121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="203" mass="22378" checksum="9E988D2314A7BC29" modified="2020-06-17" version="1">MVAYPHNTTKRISKIKRATKETRLAVQVNIDGTGKTAVKTGLSFIDHLIVAIAKHSMIDISLTAISNDGILHHLVEDTSIALSQSIDRALSDRSRIRRFGHAVVPMDESLASVAIDLVKRQFYNMQLNLAAETVEGIPCEDLEHFVRSLIQNLNACTHIVVNYGDNDHHKIESAVKAFAVALRMAASIDERRREGVPSTKGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFW0</accession>
    <name>A0A6A8FFW0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase II large subunit</fullName>
            <shortName evidence="11">Pol II</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exodeoxyribonuclease large subunit</fullName>
            <ecNumber evidence="11">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polC</name>
        <name evidence="13" type="ORF">FIO04_00545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EC" id="3.1.11.1" evidence="11"/>
    <dbReference type="EMBL" id="WJXC01000014">
        <property type="protein sequence ID" value="MRN68171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="PTHR42210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016275">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolC_DP2" evidence="12">
        <location>
            <begin position="20"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MRN68171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132639" checksum="DE16663744349946" modified="2020-06-17" version="1">MIDEAELRLKDVRIPAYYLNYQHNILKNVQKNFELAAKARKLGLDVSDGVEPKIAYDLADRVAKMHNIDIADRLRVLLSWSTKEKAALTIAEEIALAEYGNGDLRTRLDNAVRVSLAIVTEGMTIAPLQGIADVQLKNNNDGSQYLSISFAGPIRSAGGTEAAFTMLIADHVRKITGLEKYAANSYDDETGRFVEELRIYEREVGNFQFKVLDEDVVRCITNLPVELDGIDTDPVEVLGHRGMKRIHTDRVRGGALRVMNDGLIGRSRKLLKMVETLKLDGWNWLKELQGAIQTGNDDAANHRMSEVITGRPVLSMSKKIGGFRLRYGRCYNTGLATIGIHPVVPILLNHAIVVGTQIKIDVPGKASSIALVDTIEPPVVRLDNGNVIQVSTVEQAAQIRPNIDRILYMGDILISYGDFLENNAQLLPASYVEEVWSLQLHAKLLALQTSDSILTGEKLSERLIQLSKEPFSTAPTVEEAFEISRRFNIPLHPKYSFYWDCVSIDEVLLLKEKYYQYQQNVKLTDNSSSSYSSPSRSSILQFPNDNPKIKDILEKLGIIHSVNNEGKIIEIDNLDHVYTLTKLLIPTSEERNAAVPSPSPVGHDADCFLEAKDTLEFISKTSGVEIRAKFASSIAVRVGRPEKAAERKMKPPVHVLFPIGIKGGATRDILRAAKDESFYAEIANRFCNNCKLPSIGTRCRNCYALTPIRNLCVVCREEITDGINNNRCYRCGKDGKTYSPVNYSLKTAVEEAQRKLGIIAGEPLKGVKGLMSKHKAAELLEKGILRQKFDLYSFKDGTIRFDATNEPLTHFKPEWTISSIQKLKELGYTRDYLGREIVSADQLVELLMQDVVLPLDCAKHLLNVANFIDEELVKLYGLEPFYNSFSVEDLIGHLIVGLAPHTSVGIIGRIIGFTNSQVCLAHPVWHSAKRRDCDGDADSIMLLADAFLNFSYDFLPDKIGGLMDAPLLIQPIVLPNEVQRQAHNIDVTSVYPLEFYEATLKQAKAGDLVNKIEIIKNRLGNEDQFFGYGFTHSTCLLTTNIQRSAYSTLNSMDEKLEMQLATAKLINAVDPDEVASMVLTTHILPDIMGNMRSYSSQSFRCSNCGEKYRRMPLMGKCMECEHELLQTVTRGSVEKYADIAINMCTQFRVNDYLRGRVESLMTELKLIFRERKKEQFTLTEFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FFW8</accession>
    <name>A0A6A8FFW8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">FIO04_00410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000010">
        <property type="protein sequence ID" value="MRN68144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="174" mass="19469" checksum="BC716743540DDB82" modified="2020-06-17" version="1">MSAGENAPEEINVIIEIPKGSSIKYELDTTNGLIFVDRILLSAMYYPCNYGSIPKTKEEDGDPVDVLVLGNDPIIPMAVIRARPVGVLLTEDEKGHDSKIVAAPLNKIDPSFSAIKEVDDIPEYLRNQITHFFEHYKELEQGKYVKIIGWKGREIAKKQISEAINKFKSPDLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FG04</accession>
    <name>A0A6A8FG04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">30S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_01345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000042">
        <property type="protein sequence ID" value="MRN68325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="6">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="206" mass="22470" checksum="29AABB89BFB960B7" modified="2020-06-17" version="1">MSRFYRQQEQHIEWQPRTTLGMMVSSGKINSMDQIFENGMRIQEPEIVKHLLPDIKSQVIHVGIVQKQTDAGEMTRFNALVAVGNEAGWFGIGKGKAAQMRIAIDKSTTAAHLNVIPVKLGCGSWECRCNQLHSIPFKVKGKGGSVSIEIIPGPRGLSLVAGENIKGLLKLAGIKDAWTKSFGSTSTMSSTTKAIFAALRRTYVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGB3</accession>
    <name>A0A6A8FGB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster insertion protein ErpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">erpA</name>
        <name evidence="2" type="ORF">FIO04_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000067">
        <property type="protein sequence ID" value="MRN68445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="116" mass="12627" checksum="FBDE9D742ABC8614" modified="2020-06-17" version="1">MESAEQSQVVTVSPKAAQKVGEFMKQEGKDNLFLRVYVSGGGCSGLSYGMGFEEKSEEDDHIIEQNGVKVLIDGYSQRYLKGANIDYIESLMGAGFKINNPNVTKSCSCGHSFSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGG5</accession>
    <name>A0A6A8FGG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000082">
        <property type="protein sequence ID" value="MRN68505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAMP" evidence="1">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="25263" checksum="B0BAD0B88B918FE7" modified="2020-06-17" version="1">MIQDNKTLITYIDQFGKIAQPNEMPSYRLLKYLTLAYSTVSLQLINSKANGIDEQSILNMITSTDDIHSQIDAVSNNLRNVEKAGLQNELGKANDAIRTQQIELIFGSIGAFMVSLVIGRHISQYSIIKPLSRLKDAASQIASGNLDFEMKSDAQPDEIWELSTQFDSMRQMLNQRTRELETSNSQLSLANVQLNEHDKVQRDFINIAAHELRTPIQPLLLASAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGH3</accession>
    <name>A0A6A8FGH3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_02325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000084">
        <property type="protein sequence ID" value="MRN68515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="309"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="541" mass="61254" checksum="9621FFE56C304DC8" modified="2020-06-17" version="1">MFAVILATILSFYYISRYRTLNDKFSLFLGIGFLANASIDLLHVIVSYNLINEPLFLKYFIPQTWFAGRLFLSAMFAMAIAGYPILSRKEDPNTSVLSIASSFRSRKKRQVQHLSPSMSEQDRKEEEEQERRKRESRHNRLQQKILLVSLAILAGIAATSAVSSLFLVFPGLVLDNYPLHRPYEIPPLILFLVALFYFYKNRLDKKNDVFYKGIVASILIDAFAELIMSYSSASFDTAHNVAHILKDAAYFVNIIGLALSSINYNLRLKESNDSLGEINAKLREREELIRMQYERLKESDKMKSEFINVASHELRTPIQPILSLSAILRPKIQDVRQQEILDVIVRNGKRLLHLTDAILDVTKIESQSLTLKKERFDLNDVIINVMDDISLSTGFLNNENIKLSYEPQHIILEADKGRIIQVISNLLGNGIKFTKEGTITVTSEIKDSEVFVSISDTGQGLDPEVLPQLFTKFSTKSPLHGVQMGTGLGLFISKSIIEAHGGRIWAENNNGSDGTEGATFCFTLPIVNKEQQQKRQQLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGI0</accession>
    <name>A0A6A8FGI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trm112 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_09960</name>
        <name evidence="2" type="ORF">FIO03_04515</name>
        <name evidence="3" type="ORF">FIO04_02375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000249">
        <property type="protein sequence ID" value="MRN41350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000135">
        <property type="protein sequence ID" value="MRN61303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000087">
        <property type="protein sequence ID" value="MRN68525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN41350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN61303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="96" mass="11288" checksum="9DAF332D7B83FC18" modified="2020-06-17" version="1">MRKAMLDILACPIDKHYPLELFELNTRFEEGSGKDTAIIEGILFCGKCLRFYPIVDEIPIMLPDELRERQSEIDFLQKWRNKIPDKVIKSGNPWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGI3</accession>
    <name>A0A6A8FGI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000046">
        <property type="protein sequence ID" value="MRN68344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="292" mass="33325" checksum="9FA6F582EE3DB531" modified="2020-06-17" version="1">MRVARILNRDHETFTIINEEGKTITRDEIVRQLRLAVPSDLEEFLFGEYLHKIKDHLSKLSFIHDLHEFKVLPPILKSFKIICLAFNYTDQSTWIRFGETPPKEPVIYIKPRTSLIGPMDDIVCPRFVKQLDYEGELAFIIGKKCSKVSRHDAPTYVAGYFVLNDVSARDVQFIDKQYTRAKGFDTFGPCGPWLTTSDEIPDPCNLRITTKVNGEVRQDSSTKNLVLKVDEIIHSLSKVMTLEAGDIISTGTPSGTALSLSTHSWKYLKHNDVVEVEIEKLGKIRNRVLFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGN9</accession>
    <name>A0A6A8FGN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000058">
        <property type="protein sequence ID" value="MRN68411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="289" mass="31565" checksum="2D2BC37476EB9FA0" modified="2020-06-17" version="1">MSLMIRPIEQSDAESCGKIGYEAHKAISSTHGYPSEQPSEEFGIGLIRRLLGNPNSWGVLAERQGRTLGSIFLHKFPPSPVAVIGPLTVHPSAKGGVGRMLMDAALTQARKQNHHQVRLVQSPSHIRSFVLYTKSGFTLREPLFLMQGQPLKGRNNTSSANVRLVRDDNDISVCNEFCKSVYGFSREMELRQAKDQGVAAMIERDGVITGYAAGIGIFGHAVAKSNEDLKALIANASAILGPGFFAPARNHEVINWLLENGFQIGWPANLMTIGPYQEPLTPFLPSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FGP2</accession>
    <name>A0A6A8FGP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_00470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="118" mass="13103" checksum="3C81464E45D0883F" modified="2020-06-17" version="1">MQDPDAFPLSLGHTLIIPKRHYSKVQDMNREFSSAIFDLLRVVTPAVEEATGVKASTIAIHNGLEAGQEILHVHIHIIPRISGDGAGPVHSMFKNRPQISSEKLDSMLDRIKERVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH01</accession>
    <name>A0A6A8FH01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptidase I</fullName>
            <ecNumber evidence="6">3.4.21.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_03340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="6"/>
    <dbReference type="EMBL" id="WJXC01000146">
        <property type="protein sequence ID" value="MRN68715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="5">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="174" mass="19396" checksum="B9DE44F27230226F" modified="2020-06-17" version="1">MVRKEIKYVIIIALGIAIIFLGIRFAFGVTNPFYVVASGSMIPKLNIGDFVIVSHNVPFESLKVGDIIVFRTFGTTDTGQHEIIVHRVAQIVTNSHGDRIIRTKGDANADSIPSLDYPIFQQNYIGKVVYVIPQLGIITDALRPPTNYILIGLILIVLIYYLRKKNEPPSDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH50</accession>
    <name>A0A6A8FH50_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FIO04_02525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="4"/>
    <dbReference type="EMBL" id="WJXC01000095">
        <property type="protein sequence ID" value="MRN68554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN68554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="394" mass="45408" checksum="458333C66FB72B50" modified="2020-06-17" version="1">MKLRSENLSQTELTKIKHLCALDWELITAHTLYYTHGYHPYSAKYIPQIPNRLISIFSEKNDLILDNFVGSGTTLVESKVLGRNAIGVDINPLACLISKVKTTVIKKPTMREISNFLISLQRDIVHLRRNTTFSSLEEKKPILDSPVIEKLHPNIPKWYHANVIYELVAIKTKINAIRNTEVRDFLLVAFSSLLRSASNTTTGFGNLMINKNAPPKNRIFEKFSLAVANMLQSVADFSTVATNSEVTIFKHDSRKLEFINDESIDFICTHPPYMAAVPYAEYQKLSLWWLGYSQYDLEKSLIGGRRSRPDTPQRFFRDMEMSLLEMKRVLRKKKYCCITIGNPIYGGKTWKLNEFIKQNAIQIGFTHLKEISRGKYHSTMGKMKEEFVLIFRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH60</accession>
    <name>A0A6A8FH60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000168">
        <property type="protein sequence ID" value="MRN68785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="167" mass="19244" checksum="6F4CAE363DFCAE3F" modified="2020-06-17" version="1" fragment="single">PLATAGQLKTAEKFLDETFVCLYGDAVYEFDLDKMIHEHKSSKAFISMALLSYKTNLRYGFIDINDGKEGAGEKQQEKQRQRNRVIRWREKPEVRGLINIGCYVMEPEFLKLVPKSSAFGMDDAVRKALEQNRFVKGFKIESGFIDIGDKKSYLEAYKKYVKKLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH91</accession>
    <name>A0A6A8FH91_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_02730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000107">
        <property type="protein sequence ID" value="MRN68594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="2">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="83" mass="8920" checksum="FE75F5080260BAF8" modified="2020-06-17" version="1">MVTTQAYCVKCKSKRDMKDEKQVTMKNGRQAISGTCTVCGTKMFKIGGGGSTAKPLPGIKAASKKPAKKITNKAKTKAKIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FH96</accession>
    <name>A0A6A8FH96_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NosD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_02865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000116">
        <property type="protein sequence ID" value="MRN68621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="NosD" evidence="3">
        <location>
            <begin position="220"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="478" mass="51325" checksum="FE183C1B6F62DB4D" modified="2020-06-17" version="1">MPYLKGDFQITISLFVFALVTSASVFTALLISQYIAFNVLPLSIQEANAIKHKTSTASQVPSSNEGNTIPSSPPSCISYNTSTRTISVSCSSSRLTDIDNKLRDISVLAKQSPSGVWLLSANLVIAKGATFHIDSTDTKWLKINSKVDRSGGPKIGPAYIVDVFGSLKIDSVKITSWDPTTNNYAITNGSRTGTDIFILGAPRPSIVVDNNATGTTDISNSEIAYLGYEQGKHKGGSGLSYYYGGDGSVIKNNIIREVYFGLYTFGVGHMTVENNIIRNSGHYGLDPHTGTHDMIIRNNTVYDNKGGSGIICSLDCYNILIENNKVHDNAGDGIDFSRNMYNSIARNNIVYNEPSGVFVSQSHNNQIYNNTISKSGDGININSGSSNNKILGNTITNSINNAILLNNGSSGNTFSSNKIVSSTPQGLKIEQDPTSKNNIFSDNQIIRSSTETPAGPEAASSQGSHAKQILPHHNSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHC6</accession>
    <name>A0A6A8FHC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000191">
        <property type="protein sequence ID" value="MRN68855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="170" mass="18558" checksum="7904DA05250430CF" modified="2020-06-17" version="1">MLKTNISQRVAVVALLIVSTFAVAGLTAVTVLSDSIAVAQGLGNDPIAGCIKTVGETWVGNTVGDKQNWNESRQNFVSLLTTDNTIKLMNQNIVHNGFPEDPAKPITDTAGIWSMLNNGNMTQYDRFHLFYNEVNHNLADARPGFTHVQQIALSRCITTEVNSLGRTSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHE4</accession>
    <name>A0A6A8FHE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000122">
        <property type="protein sequence ID" value="MRN68644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="61"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="207" mass="22175" checksum="666380042FC3D8A4" modified="2020-06-17" version="1" fragment="single">MSLILKNVSLLLGKDLTFVAEGYLEIGKDGIIKQAKRGPYHRGDDQKAHNNTIFDAEGFLIIPGLINAHTHIGDSLGKDVAVDSGLDARVHPIHGAKQKILQRSKPDHLKTFIRGSALSMMKKGITTFADFREGGTEGVKLLRDAISGLPIKCIVFGRTEYYVDITSSATGASQRNLPSSSLQMASDVLGISDGLGISGANENSDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHI5</accession>
    <name>A0A6A8FHI5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_01870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000062">
        <property type="protein sequence ID" value="MRN68426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="3">
        <location>
            <begin position="45"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="243" mass="26314" checksum="0579227381F70640" modified="2020-06-17" version="1" fragment="single">VQDTSTTTITSNEKVGNIESNSDGGGRWQQKQQQQRSSSTMILTRTRLNIFLNTVYFVLGFSLIFAVLGVILNSVLSVYGAGFQHYLTSVGGIVIIGFGAYLILSTRIRGLNFEKKMTLGRIPRFKTSYITSFVFGAAFAAGWTPCVGPILGSTFALAATHPAAAYNSLLAYSIGLGIPFLITGAFFSRATGIIRRMVKHLKYFNLVMGGILVVVGVLLFTNQLILLANFPLANQIINIQSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHJ3</accession>
    <name>A0A6A8FHJ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_11400</name>
        <name evidence="3" type="ORF">FIO04_04470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000345">
        <property type="protein sequence ID" value="MRN41630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000225">
        <property type="protein sequence ID" value="MRN68935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="96" mass="11184" checksum="5D672B25729D09A9" modified="2020-06-17" version="1">MKYRDRTEIITLILASASRMNGVLKTRIMYEAFLSFSQVEEYIALLLRNSLLEHDDLKKTYKTTEKGLRLLELCNSINEIVDTKKTKKDEKNSVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHK0</accession>
    <name>A0A6A8FHK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000228">
        <property type="protein sequence ID" value="MRN68945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="113" mass="12418" checksum="94EC0B73A9056DED" modified="2020-06-17" version="1">MVMRDHEPKVFTDLRSIILPAKFQYLTAGLSSTINSSWGGLAVTEYCPHINCSRTLQVHIGMMKLLTSNLANGHTVVAAKASSLLFAIVATIFGIILTKNLMHLASKRYVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FHV0</accession>
    <name>A0A6A8FHV0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_02430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000090">
        <property type="protein sequence ID" value="MRN68536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="183" mass="20823" checksum="B9D0F2346AB8186D" modified="2020-06-17" version="1">MVDNLKRGLMVGRFQPFHKGHLCLAGQIFEDCDEVVIAIGSAQINYSYADPFTAGERIMMIHAALVESKIDLTKCHIVPVVNDENNARWFGHLKSMVPHFDILYSGNEFVTNLVSGQIEILKPRFSRRKEYNGTNIRKLMSGTHRWKKLVPDAVAGIIEQIDGVTRIRFLLNEKLSEREKNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI26</accession>
    <name>A0A6A8FI26_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5 8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisA</name>
        <name evidence="11" type="ORF">FIO04_00305</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5 8 10"/>
    <dbReference type="EMBL" id="WJXC01000006">
        <property type="protein sequence ID" value="MRN68123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="236" mass="25518" checksum="A0FC596567923432" modified="2020-06-17" version="1">MRVIPAVDIMDGNVVRLVKGNPADKVIYGNDPIETAKKWEKAGADMLHVVDLDATLRTGRNNSEIVSRIIGAVNIPVEVAGGIRSVPAVKEMFHKNAARVVLGTMAYKNPDSVRQLAKKNRNKIVISLDQNNGMVMIDGWRETTGSGVIDSMRFFMNMGIKEFLLTSVDRDGMMNGPDITVLSSAVSFTSANIIASGGISSIEDAIRVRNIGCSAVILGKALYEDKLSVERVKAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI38</accession>
    <name>A0A6A8FI38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="8">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpA</name>
        <name evidence="10" type="ORF">FIO04_00795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="8"/>
    <dbReference type="EMBL" id="WJXC01000023">
        <property type="protein sequence ID" value="MRN68219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="282" mass="31090" checksum="D4A1E91CB64CAFF0" modified="2020-06-17" version="1">MKRTSLGNNRLNRKFQELSEKNEAALICYVVAGYPNIPTTNEILSSIVKGGADVIEIGIPFSDPIADGPTIQEASYRALLAGVTPEKSLEISKNIRKKYPSLPVVILTYSNILQRVGFEYFMKKSKECGVDGFILPDMAIEESDKYVMEASQLDLATIFLASPNTTPGRLEAILARTSGFMYVVSVYGITGQRRSFEDYSLTAIRNVKQVVGSRMPVAVGFGISSPSHIKPMIRAGADAIIVGSAIVNIIRNFSGNKRKMLQQIEVFVRDLKKACRQNYLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI55</accession>
    <name>A0A6A8FI55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000224">
        <property type="protein sequence ID" value="MRN68934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="342" mass="39188" checksum="5A1516547F41F897" modified="2020-06-17" version="1">MTDIISWDKAIDKKVKSSDDKDLGKIQSVTRDYIQTKEGTVDKKYYYIPKYYLQGYDGDHLWVSLTKDDVKSRFEGEKAPPAATFETPDYVQRKTTVTKQYPDFETNIPTYAGTSATASDSVAMPWDKIIDRKVKSSDNEDMGKVESIATSYVEVKEGAVHKKRYFIPKYHVQGFDGEYIRTSLTKNEIKDRYERDSPPTESEFQTQEYVEQKRKVDSTYPQFLHGIPFMAKESGVKLQTEQSGETLNIPWEEIIHKRVKTTDNVDIGDIEQVGNEFIVVREGVARIRHYYIPKSYINNYDGSSVYVAAPSGLVSAKFERETEPTPEDIRMLANDAPPRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI62</accession>
    <name>A0A6A8FI62_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fen</name>
        <name evidence="15" type="ORF">FIO02_03365</name>
        <name evidence="16" type="ORF">FIO04_00455</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">AHI_AL_Thaum01</strain>
            <strain evidence="15">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="WJXE01000039">
        <property type="protein sequence ID" value="MRN40068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000011">
        <property type="protein sequence ID" value="MRN68153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 11 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="14">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="53EXOc" evidence="12">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="13">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MRN40068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MRN68153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="340" mass="38247" checksum="A375A6C3B2ACA4BE" modified="2020-06-17" version="1">MGLDLKPFVMPSPIVISELANKVVAVDAHNAIYQFLATIRGPTGELLTNNKGDVTSHLSGLFYRNINLLADNLKLVYVFDGKPSLLKSKEIERRRQVKEEASQKYQEAVTEGRFEDARKYSQATSILTDKMIEESKEILNLLGIPSIQALSEGEATAAHLTKTDIAYTCASQDYDSILFGAKRLTRNLAISGKRKVPNRNMYFEVETEIIEHQQVLDQTKLTQEQLIDVGILIGTDFNPGGVPGIGPKTGLKLIREYGKLENVEKIKNTLSDIPYQEIRDIFLKPEVSNADGVEFTEPRYDDIINFLCIEKNFSTDRVTGSLEKLKKSIAQRTQSLEKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI68</accession>
    <name>A0A6A8FI68_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps8e</name>
        <name evidence="6" type="ORF">FIO02_00145</name>
        <name evidence="7" type="ORF">FIO04_04565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="6">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000001">
        <property type="protein sequence ID" value="MRN39443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000231">
        <property type="protein sequence ID" value="MRN68954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00029">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020919">
        <property type="entry name" value="Ribosomal_protein_S8e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="PTHR10394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN39443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="127" mass="13806" checksum="2409693985049CCD" modified="2020-06-17" version="1">MRKSLENLAGRKASGGRRVASRARRKFELDRYPNEAIAGTTITTTRRTRGNNIKTALKSAETVNVLDPSSKKTTKLAIIRVTKNPANKDYERRGVISKGALVDTEAGTARVVSRPGQDGSVNAILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI72</accession>
    <name>A0A6A8FI72_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">tmk</name>
        <name evidence="4" type="ORF">FIO02_03160</name>
        <name evidence="5" type="ORF">FIO04_00505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
            <strain evidence="4">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="WJXE01000035">
        <property type="protein sequence ID" value="MRN40028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000012">
        <property type="protein sequence ID" value="MRN68163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN40028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="238" mass="27554" checksum="06DC2137D72B01D0" modified="2020-06-17" version="1">MKRVLQSKKLETKGKLVVVEGIDGSGKSTQIRLLEKWLRFRGVQVFLTEWNSSDLVKQITSKGKKKGTLTPTTFCLLHATDFADRYERNIFPLVQAGYIVLADRYVYTAYARDIVRGCDPRWVREVYDFAIKPDLVFYFRVPIDVASERILAGRPKLKYYEAGMDLNLSNDLYESYRIFQSRIIDQYESMIQSERFLPIDGTSGIEEQQQLVRKKIAEIIPQGKGPIRIMKKQVLKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI83</accession>
    <name>A0A6A8FI83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribose 1,5-bisphosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000230">
        <property type="protein sequence ID" value="MRN68951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="80" mass="8689" checksum="FBD2703D34DB6306" modified="2020-06-17" version="1" fragment="single">YVKWKGMDPMWVEGSEDAVVNYTDEVFPGLIASGMSVTETHGLPRMGPTFGSMLLSGKKAAEVAMGKLKEMPDSPKLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FI86</accession>
    <name>A0A6A8FI86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000323">
        <property type="protein sequence ID" value="MRN69155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="311" mass="35730" checksum="A76FB79AE8F850C7" modified="2020-06-17" version="1">MNYVDEIISVLKKSGFADRYLLYSQVENAKMADITKTIAYLQQKKIIRVEGHRKNSRTGLSIPIYSLASEHSSLNTTHRGIDRLDLDELLAGVLSERVVEYGFLARNLLPSRSNMKILDVGSERSALTKALSKCGNNKKWEVFGIDIAKGIHRAFKEEKEEPGHLFMRMDARFMGFRDEVFDKIICISTVEHIGIQSSHYIVGENDVLGDVKALSEIFRILKKGGRVVLTIPYIDRSTRGNHKEHRIYNSYTLSKLISRFRVKRKEFYIYIEGKWKSCKLKNIVNKLQLIGNSEIPSYLHSRVCLCLLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIA4</accession>
    <name>A0A6A8FIA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000248">
        <property type="protein sequence ID" value="MRN68994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="92" mass="10345" checksum="9914834B4605C298" modified="2020-06-17" version="1">MNKDLTQEEAWKIMQPVCRELLELVDGGYLQFVSASYNESDGTYKINLKSSHIHLASRGFKDSIGDVEYNQGKIRIGLRANGIPANIFVDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIB9</accession>
    <name>A0A6A8FIB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_09785</name>
        <name evidence="3" type="ORF">FIO04_00710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000241">
        <property type="protein sequence ID" value="MRN41316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000020">
        <property type="protein sequence ID" value="MRN68203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="338" mass="38531" checksum="0328C0BB5F42EC3D" modified="2020-06-17" version="1">MNDMSKKFYQLAPDLTICRIANGMWQVAGGHGYIDHELAIADMMKYHDAGFTTWDLADIYGPAEDFIGQFRRKLSALKGKEELNRIQALTKWVPQPGRITRSIVNENIERSLRRMSVSSLDLLQFHWWDYNNPYYMDALKCLSDLRDDGIIKHIGLTNFDTERMQIMIDSGLQIVSNQVQYSIIDRRPEVKMIPFCLEHNMSLLTYGSLCGGLMSERYLGRIQPSTAELNTLSLRKYKQMIDAWGGWNLFQELLSTLKRIAQKHSVSIANVATRYILAKSAVAGVIIGVRLGIVDHINNNVQVFNFCLDKPDCDAIDAVCTKSNDLFEIIGDCGDEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIC8</accession>
    <name>A0A6A8FIC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000247">
        <property type="protein sequence ID" value="MRN68991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="217" mass="25311" checksum="910BA896456A2DBC" modified="2020-06-17" version="1">MISPCQTKDNKIICNNYSSALGTLKEKLYNGNYYTSANSSVCVAYTRRIHRYQAFSSQDNSISTNENPRSKENYDTIRILDIPTSSDDFDKYIESQMELAKLNNNLSGRITDYNELEEQRREIRKELIDSIIYTQTSRVGEKEVAYFEYDDGNSEIVKRCIRKIVKKYKEQQDQHTTISIENIQQILAGHDIPKEIAKELAILILKDKIVDQTIRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FID2</accession>
    <name>A0A6A8FID2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps3</name>
        <name evidence="10" type="ORF">FIO04_04915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000262">
        <property type="protein sequence ID" value="MRN69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_S3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_S3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="242" mass="26235" checksum="C1C9B4B059CC4C33" modified="2020-06-17" version="1">MKNNFRNLELDEYLASTLKDAGYGDVEVQKTPIGTRITLYVTRPGLVIGRKGTGIKDLTTRLEEKFGLTNPQISVLEVSVPELNPKIMCNRIAQLIERGTAFRRAAMWSMNTIMNAGALGVEVAIAGKLRSERAHFEKHSSGVMPKSGHLAEQIVRIGITSVLTKMGLMGIQLRIALKGELPQEFEFSESSTQVDSAQSQIPTDVGAEQSTTPATAAGDVALKPRQTDRETIVAPGNTNGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FID8</accession>
    <name>A0A6A8FID8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000150">
        <property type="protein sequence ID" value="MRN68726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="242" mass="26462" checksum="70A9DCF611D7E43B" modified="2020-06-17" version="1" fragment="single">SKGYSGIVINGRKMDGVREVADEIRGEGCDSLAIEADISNENDCIRLVEEANKAYGRIDVLVNNAGIQTDVPFEETTTEEWYKIIGVDLTGPFVCSREVAKHMEKQHPKGGCIINISSVHQTIPKPHYIPYATSKAGVEMMTKTMALELAKDNIRVNLVAPGAILTDMNIELKENKAELEKVLKQIPIGRIGTPEEVANVVEFLASDKASYVTGASFFVDGGMTLYPNFGIGPEHDALRHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIE5</accession>
    <name>A0A6A8FIE5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplJ</name>
        <name evidence="2" type="synonym">rpl10</name>
        <name evidence="2" type="synonym">rplP0</name>
        <name evidence="4" type="ORF">FIO04_05885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000354">
        <property type="protein sequence ID" value="MRN69215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_L10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="50S_L10_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RL10P_insert" evidence="3">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="297" mass="32893" checksum="4B02F6C4B2285106" modified="2020-06-17" version="1">MASQVEVDTQRKNYPKKKRLLYQELQELPGTYDVIALSKMSKVRATQLMTIRKKFRNEIKIRVIKNRVAQRAFEKLSNRPGLDYLSKELEGQCALLFTNISPFKLNLIFDKNKVFLPAKGGDIATKDIIIPAGNTGISPGPVLSEFKEANVSTKIDQGTIWVGKDTVVVRSGSIISQKLASLMSKLNIKPIEAGISISLAIAEGLVLKENDLKINLAEYREELTRSFHEAVSLAIETSYPTVETITHLLVRAYQNATALATDSGYVSPDSVQFVLVRANANGQIIANQVKKSGYIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIL2</accession>
    <name>A0A6A8FIL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CDC48 family AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_01175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000036">
        <property type="protein sequence ID" value="MRN68293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="211"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="484"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN68293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="726" mass="80004" checksum="1EDD384239BA2B4C" modified="2020-06-17" version="1">MAQGDNLKILESYTRDVGRGVARIDYDSMDSLSASTGDVIEIRGKRRTVAKCLPLYPSDEGKGIVRVDGLVRNNAGVAIGDTVVVRKIKAVPAEKVIVAPLEAIPPIDERYLADALESVPLIKGDNVMVPYFGGRLTFQVVGVTPPASDAVLVTQKTMFHIAERGSALRGGTAQVAYEDIGGLKDEIQKVREMIELPLRHPEIFEKLGIEAPKGILLHGPPGTGKTLLAKAVASESNSHFISISGPEIMSKFYGESEARIREIFKEAKEKAPSIIFIDEIDSIAPKREEVTGEVERRVVSQLLSVMDGLEARGKVIVIAATNRPNALDPALRRPGRFDREIEIKVPDKRGRLEILQIHTHNMPLDTDVNQDRVAAVTHGFVGADLEYLCKEAAMKCLRRLLPELNLEDEKIPPETLEKLVITMNDFDNAIKEIMPSAMREVYLESPDIPWTEIGGLEEVKRELQEAVEWPLRYPNLYKELGHTVPKGILLHGPSGTGKTMLAKAVATESEANFISVKGPELMSKWVGESEKGVREIFRRARQASPCVIFFDEIDSIAPSRGGGMEGGVHSSAERMVSQLLTEMDGIQEIHEVVVLAATNRIDMIDTALLRPGRFDKIVYVPKPDVKTRQKILEIHTKGKPLGRDVDLITIAEVTEGFSGADVSAVANTAVSLVLHEYLARYSTPEEAAKHSSEALVSMQHFEEAVKKIRIQREMKPGEKITMPQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIP2</accession>
    <name>A0A6A8FIP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nickel pincer cofactor biosynthesis protein LarB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">larB</name>
        <name evidence="2" type="ORF">FIO04_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000042">
        <property type="protein sequence ID" value="MRN68323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="124"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="273" mass="28703" checksum="34936652DDD28074" modified="2020-06-17" version="1">MDLKTILEKFAKGELALEDVHKQISIHSIEHVGNNLAKLDIGRDFRKGVPEVVLGEGKYSRDIVRIVLSAVKIKGNVVVSRIRRDELSKICKTLKNKNLHIQVGKSSTTILVKANLDANKHSGGKIGILSAGTSDIGVAEEARLVAEAMGCDAITDYDVGIAGLHRLLPAMQEMISADVGAIVVVAGMEGALASVVSSMVNVPVIGVPTSVGYGFGSAGVAALSCMLQSCALGLAVVNIDNGIGAGAFAALIANRIKRNLFETKHQESEVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIS5</accession>
    <name>A0A6A8FIS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA pseudouridine(13) synthase TruD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">truD</name>
        <name evidence="3" type="ORF">FIO04_06455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000414">
        <property type="protein sequence ID" value="MRN69325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="2">
        <location>
            <begin position="164"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="327" mass="37138" checksum="4D8603ABF16A6BC9" modified="2020-06-17" version="1" fragment="single">MIKFPVPIIDQKAGMNCYCTSFKGVGGLIKQQADEFRVSEIIDPAVFNDLSSVQDQLHRYPLYILEKSNIDSNHAISQIKKRFGIPLKVIGLKDAKAITKQYATTEQLKNIPREIRTDQIFLTLKGFSRKPLAKASLLGNEFTIIISSNNNQLDTSTFEREIKNIANFYGLQRFGSERSVTHLVGREIVRRNFKNAVELLLCYTSEYDSKTSREIREKSRDPHNYARLLKLLPRGMDIECQLMSAILQGKDVIHALRVIPINMRRLFVQAYQAYIFNICLSTAIRNGENLLKGKEGDLCFEIGGPLIFGKIRKFNSISDSESNVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIT3</accession>
    <name>A0A6A8FIT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_01595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000051">
        <property type="protein sequence ID" value="MRN68373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN68373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="247" mass="27124" checksum="438EAE577DC4E248" modified="2020-06-17" version="1" fragment="single">MIRTWLRAIRLRFLSASVIAVSNGIALAFWKNKQIDLSDAILTFAGVICLHASIDLLNDYWDYKRGIDTATRRTKFSGGTGVLPENLLKPGNVYSVGLIFLLIGTLIGMYFVVIRGIMIALLLGFAILAIYFYSTSIVNLGLGEAFVAIKGTLIVVGSYYVQTSSIGVGVVYVGIIMGILSASVLFVNSFPDYQADRSRGRRTLVILLGRQRAVKIFPWMILCTYVLIIAGIFLGYLKIYSLASLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FIW7</accession>
    <name>A0A6A8FIW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO03_07805</name>
        <name evidence="2" type="ORF">FIO04_05760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000327">
        <property type="protein sequence ID" value="MRN61927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000341">
        <property type="protein sequence ID" value="MRN69191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN61927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="60" mass="6845" checksum="45B45191F07F9962" modified="2020-06-17" version="1">MVHSKKAELEVKIEVDMPVDIIDDKDRLKAVEKGLVRSISKGLYEQGVSFKVDKVNFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ07</accession>
    <name>A0A6A8FJ07_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000376">
        <property type="protein sequence ID" value="MRN69254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="61" mass="6639" checksum="C3E4ED6E06D4F820" modified="2020-06-17" version="1" fragment="single">MRGEDTATADTQDTESQKDLELAEREQQLPLEIQEKMNRGVLRTGFTTGTSATAATKAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ10</accession>
    <name>A0A6A8FJ10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FIO04_04325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000210">
        <property type="protein sequence ID" value="MRN68906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="3">
        <location>
            <begin position="309"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="434"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="494" mass="54329" checksum="7C1095DC73D92965" modified="2020-06-17" version="1" fragment="single">MKHTPRISSALKAVDLRQEPPPLIIGERLNTQGSRRAKDMVLNSDYDGLVNLARTQIEDGAHCLDVCVATTERADELEFMKSLAKRLSLEIDAPLVIDSTDPKVMEAALQQIPGRPVINSINLEGDGSRFHALAPLMAKYGVPAITMCIGPGGMAKTPQEKLETAILLYETGKKYGLQPWQFIFDVLTFTLATGEQEFLESAKATLEGIRLVKQKIPGCFTVLGLSNVSFGLTPNARKIVNSIFLHHAIKAGLDAVIINAKDIIPYLDIDREQRKLAEDLIFNSHPNALAELITFFEGVKSVSGASSKRIEVDPSWEASKRCYFRIVHRLKDGIESDVVDSIEDRIHVNLTASKNIEINSYMKKKVILEAPKQVVHDAAVQTLNEVLLPAMKEVGDKFGAGELILPFVLKSAECMKAAVSELEKYLIRREGVSKGKLVLCTVYGDVHDIGKNLVKTIFTNNGYSVYDLGKQVPLQSIVEKIKEVNADAVGLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ29</accession>
    <name>A0A6A8FJ29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_00735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000021">
        <property type="protein sequence ID" value="MRN68207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="71" mass="7914" checksum="7D7D29F8641E0A90" modified="2020-06-17" version="1">MSYSCGNSGCSVVHVRAFERGLIARKQHSERMKPFGLKTEKESVNSVLNEIGSSEGRRDDGMVFGLEESEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ62</accession>
    <name>A0A6A8FJ62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000520">
        <property type="protein sequence ID" value="MRN69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="283" mass="33718" checksum="D0B4302F42608B82" modified="2020-06-17" version="1" fragment="single">MNLKQWCELDERIYIGETDEQYKQYAGFDYSEKLIEQLAEIKLYNSKIFIDFFSDPRALLLGAIEDTAYSKNKKLELELHNTRNTKIVSTKHKFKDSFVNWSTWRQFNSLEKNQLNRKEVFDEFIAKTKYISPIVESRFSSIKQVYREHQIVKDAKDSDKISPLSSYLENENVSYNQLIEFIKSIGNRAKKPFRDALTDISKKMLGREPEYYDDFYFFRNKVYSSLETNFSSINPLIEVRKILAFMQFDLAKIVFDTESRKNKYPSPICFFVQIPNDIRILYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ69</accession>
    <name>A0A6A8FJ69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YjbQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO02_09515</name>
        <name evidence="3" type="ORF">FIO04_03990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000230">
        <property type="protein sequence ID" value="MRN41265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000185">
        <property type="protein sequence ID" value="MRN68842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN41265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="139" mass="16015" checksum="8DE55D5696E3363F" modified="2020-06-17" version="1">MKSKTEYLTFNINTRRAFINITPDVRRTVEGSKIKEGLCLVNAMHITASVFINDNERGLHEDFDIWLEKLAPHAPTEQYKHNETGEDNADAHLKRQIMGREVVVAITNGKLDFGPWEQIFYGEFDGRRDKRVLVKVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ84</accession>
    <name>A0A6A8FJ84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000089">
        <property type="protein sequence ID" value="MRN68533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="129" mass="14749" checksum="C41D8DDCD1137053" modified="2020-06-17" version="1">MAIRKQNFFQRYRKVILFNKNLILSGVISFLAGALTTQIYALFDSNNLSNALITLLIGYCVYIPLFAFLFYRDNKSRYVDPLTGKKLFPATIICSTISGSHISRINSLGSISYFNKHWYQSCKAVQMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJ96</accession>
    <name>A0A6A8FJ96_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FIO04_00240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000005">
        <property type="protein sequence ID" value="MRN68110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="400" mass="45464" checksum="C9FE0E73C2B7D51A" modified="2020-06-17" version="1">MLELNHSEGSSDTSNDEDDNSINNSKHDFKVTPWEVEGEIDYNKLIAQFGTQPITSEIIERIKQVTGEVHPMLKLQYFFSHRDLDWILNKHEEGESFYLYTGRGPSGMVHLGHMMPWLFTKYIQEKFGSKLLFQLTDDEKFLQTQDRSREEIGHYAYENILDIIAVGFNPDKTKIILDTRHIQHLYPIATEIAKRITFSTAKAVFGFSNSTNIGMIGFPPIQAAPCFLPSIIENKPTPVLIPAAIDQDPYWRVTRDVAERMGYYKPAQIHSKFLPGLGMVGKMSSSKPETALFTIDDPEVIDKKVSAAFTGGQATVALQRQLGGNALGCPVFWYLRYLFDTERQSDERLLKCTSGNLLCGECKSDLSKESQNFLGEFKKRREKAKDVIAEFMFDGAPYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJA2</accession>
    <name>A0A6A8FJA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000202">
        <property type="protein sequence ID" value="MRN68882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="48"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="199" mass="22546" checksum="92CE9DBEC2DD4100" modified="2020-06-17" version="1">MYITGASTVKATPSNQGQISSRISVLPIAQNGNTGNRFYPVAQFEIDKSHFKRAPEFTGITGYINTPAPIRLADLKGKVVLVHFWTYTCINCIHTIPHLNDWYQKYSNKGLVIVGVQTPEFSTEKNIDNVKTAVHNFQIKYPVILDNNYASWNAYGNNYWPRDYLVDNQGYVRYSHIGEGDYDQTEQMIQSLLAEGVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJD2</accession>
    <name>A0A6A8FJD2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000104">
        <property type="protein sequence ID" value="MRN68583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="76"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="444" mass="50371" checksum="D9D6B47E8ECC6265" modified="2020-06-17" version="1">MNVQTQPLLLQSREKWSVNGSSRIIPPEQTLRMTMSLSKQIGVTRLADITHMDKLTIPNYSAVLPGTEDYIWVYSGKGPTKAHAKASALMECIERYSSLPSSTRRDFIQGSYDQLSQRYTVLHPEEVVEPFNFQYRNYMTMDFLPGFELFSGERMLVPASLALFRYTPKPPALNPFAFYHTNGLASGNVLEEAVCHSLCEVIERDAISLAELRASAIPFHFIRTITNSLKAKQYSVSPVPADQFMDDSSIFPDVDIRDVDFDPIKMLVRKFEKANIPLIIKDISSDIGIPTFNASSIEWLTHDYGYLAEGHGTHPDARIALLRAITEVSQTRAANIQGARDDLRKIKYGHDNSDDKRAWQFTPSKNKIQFSQVRSYFNRDILDDIKLILARLQHADLKKAIIVDLTIAKIGIPVVRAIVPGLETFKFTKSVMGWRAKKYFKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG6</accession>
    <name>A0A6A8FJG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_01505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000049">
        <property type="protein sequence ID" value="MRN68357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="59" mass="6401" checksum="74B4636BF871650E" modified="2020-06-17" version="1" fragment="single">MTQFLREGKDWERKATNIPGVFILKLPSFKGRSASLAIEVNPIGSSGAATKKRGVVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJG8</accession>
    <name>A0A6A8FJG8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps12</name>
        <name evidence="5" type="ORF">FIO04_06745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000453">
        <property type="protein sequence ID" value="MRN69381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="145" mass="16169" checksum="36B1F035C0220366" modified="2020-06-17" version="1">MARSPLGLFAGRVLRTKRNRGKWSDKYYKRRMLMLDKKANPLEGAPQARAIVLEKVGIESKQPNSAVRKCVRVQLIKNGKSITAFLPRDGALNFVDEHDEVILEGIGGSMGGAMGDIPGVRWQVFKVNGVSLNELVRGKKEKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJM1</accession>
    <name>A0A6A8FJM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000151">
        <property type="protein sequence ID" value="MRN68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="347" mass="38628" checksum="B2C597227C8A622F" modified="2020-06-17" version="1">MLLYIIVLIVSREIRLKKRPMGIPTNDNFELVEVQVPDSNDGEFLVRNIWMSVDPYMRGRMTERKSYVPPFELGKPLDGACIGKVVESKNNQFAVGDYVLGMNGWREYWISDGSSNSGATKIDSNLGPIQFFLGIFGMPGLTAYIGLLKIGQLKEGETVFVSAASGAVGSVVCQIAKAKGCYVIGSAGSKEKVSWLNDARIDYAFNYKEFKDDISTELGKAYQSDGIDLYFDNVGGKHFETALDHMKTFGRIILCGMISQYNATSPTPGPTNIFLAITKRLKLQGFIVRDHYDMLNQFHADMTKWVNEGKIKWKETVFEGLENAPKAFITLFNGENFGKTLVKIGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN4</accession>
    <name>A0A6A8FJN4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Na_Ca_ex domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FIO04_07050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000493">
        <property type="protein sequence ID" value="MRN69441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="7">
        <location>
            <begin position="39"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MRN69441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="254" mass="27593" checksum="F63B84748FEAA3A0" modified="2020-06-17" version="1" fragment="single">MDFDNSDIHGKLSKSSVLYFLVLFAPMALVLEFTHSEPLLIFIFAAIALIPLAKLIGDSTEHLAIHYGTTIASLLNVTFGNAAEIIIGIVALSAGLVNLVKASIIGSIIGNILLIFGLSLVVGGLKQKEQFFNKENTSYQSSMLFLAIIGLAVPTILSITVANPTTEVGLVEGQGNIQFISDVLAFVLLGVYIASIIFTFVTHKHLFAIASMEREEVNGRRRGTEGNKLYNDIDNHRQHSGDSHWSKKKSILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJN8</accession>
    <name>A0A6A8FJN8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">psmB</name>
        <name evidence="11" type="ORF">FIO04_00955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="WJXC01000028">
        <property type="protein sequence ID" value="MRN68250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5025745583" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025745584" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MRN68250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="219" mass="23946" checksum="AA48A97727BEE752" modified="2020-06-17" version="1">MRSQDNRYEEYIAEHIRKGTTTCALTCKDGVVLAADTRASAGFFIADRHVMKIQRVDSHLGMTIAGGVADAQNLVDIMRYNANIYRISNKEPMPVKSAARLCSNVLFNQRYFPYYVQIILAGFDSQGEGQIYNIDLFGSMTSDKFIATGSGSPVAYGYLEAEFKADLGVNDAYKVAVQSIAAAIRRNAGTGDGINVVIIDRNGYRELSKETKAAVGAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJQ0</accession>
    <name>A0A6A8FJQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000265">
        <property type="protein sequence ID" value="MRN69032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="196" mass="21430" checksum="4C6306CD78829B78" modified="2020-06-17" version="1" fragment="single">MFRIDFSLRREIFFVVIGAVLGAVTMVVPITFLYTGLGLPYYLTWMAFGHVIGVYSSPSSIIAGIAIHMITAISIGVAVGVFLYKTGILNISKLSNGLLYGLLAGSIVFVVFFIPVYQFILAPEITRTMAAVKVTTTSQGKEYATTTITTTSTPQYHYANNFTVIMIVWLLIHLVFGTVLGGVSSCISIRFGSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJS4</accession>
    <name>A0A6A8FJS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type II methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_05140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000283">
        <property type="protein sequence ID" value="MRN69068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="64"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="390" mass="45957" checksum="32106555EC4B5249" modified="2020-06-17" version="1">MPSPLQKKSKVKLCWASDNEYKKTNGIKEPIRILKNSTSGNLLFHSDNLTSVNYLLENGFEQKIDLVYIDPPFGRGEKYYHRMKNVENPAFEDVFRGKIDEYLDMIYPRLEVIQKLISARGSIFVHLDWHLLHYVKVIMDEIFGYENFRNEIIIKRGRRKNLLYQFKSIDRMHVANDSILWYSKSAGTKFHHPLVKNKRNSKWMGFWSNVNRPTMRYELFGFVPERGQWKWSKARALLAIENYKVYVGKFADIPLEEYWRRTSQNMEFIRKRPSVKYPEYWIPPKTHVILDNIWTDIEAYSYSTGYDTEKHEQLLERIIGQFSRARDLVADFFCGSGTTLVVAQRLGRNWIGCDCSSTAIQVTERRLERSDFSLIKALKPRGKYCGGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJV3</accession>
    <name>A0A6A8FJV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsK</name>
        <name evidence="4" type="ORF">FIO04_05785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000343">
        <property type="protein sequence ID" value="MRN69196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN69196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="36" mass="3969" checksum="60CD72F85C616D45" modified="2020-06-17" version="1" fragment="single">MSTDIAEVTQFKWGVAHIFSSYNNTLVHITDVSGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJW6</accession>
    <name>A0A6A8FJW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="WJXC01000540">
        <property type="protein sequence ID" value="MRN69511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="243" mass="26403" checksum="1E1BEF953EBA9860" modified="2020-06-17" version="1">MKDVKAFAVDIDGTLTENGGGMVYLNGVATLRYLEYLGCRVVYVTGRASIEAYVLAVFSGTTHVAVGENGGAITTAPDKHTLLANKQNCLKGYEILKENIDGVQMKPVFNRLTEVVLSRTFDIREGSKILEENNLNLSLSDSKYAYHINEKGVNKGVGLLEALKILNLDPQETVAIGDSETDLPLFDLCGCSIALNHAEDTVKSRATHVVRGTEGRGLVDAIDLVAFNYLDTGTQNDFSRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJW9</accession>
    <name>A0A6A8FJW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000182">
        <property type="protein sequence ID" value="MRN68829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="262" mass="29762" checksum="3BABD5838DD4C0EA" modified="2020-06-17" version="1">MGISDLKRVLLSSFHSSVIDALMKEDYEPENILSFDSHLDVDIVGALETVWNAVRGYNGYDKGLHFALTDSAIHMLARKWFPNTEIKIVTPRVCMEGEVKAESYWLKQLDISLALSPPKDIVSFATLVNNDTVIDVDFDYLGDLQNEIYIPRMGPDYKPYEFGSLERLLRLIRATKPDLITCSEATIAALNDPNSKTNYFLGKLRNMGYEIKKHFLFSSDEEAIARLVIIRRFSIYLENNSSSEPDRSLDEIEDAANEFFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJX4</accession>
    <name>A0A6A8FJX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_03695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000168">
        <property type="protein sequence ID" value="MRN68783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="133" mass="14506" checksum="035EE05F8626CA58" modified="2020-06-17" version="1">MATKTKPKGKKKGKQTTSAKRSRATPKRKVSKAQSTRKPSNRGASVTRTKKISRRPKKSTRGSRTVSRKERPTGLEGTQSSSGPTTRIYESQEVTAFGSTVNERDEDETITTSTVSPSEESDENSNDSSALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJY5</accession>
    <name>A0A6A8FJY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000308">
        <property type="protein sequence ID" value="MRN69122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="70" mass="7984" checksum="0944440E655B0055" modified="2020-06-17" version="1">MALAVIDRLCMEKTLISVKEFPVPEVGRRQKDKRKRCVLCGNLASHEAIFRVQGASLVEWYCGAHVKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FJZ6</accession>
    <name>A0A6A8FJZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000364">
        <property type="protein sequence ID" value="MRN69236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="68" mass="7019" checksum="EADBC4CCFC56CBB0" modified="2020-06-17" version="1" fragment="single">MILKAEKKEELPIRLTKKIDGLITSSFALCNRFSAYSSCDSGACSRSSYSSGGDGCDDGGGDDSSGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK18</accession>
    <name>A0A6A8FK18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO02_04465</name>
        <name evidence="2" type="ORF">FIO04_05515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
            <strain evidence="1">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000060">
        <property type="protein sequence ID" value="MRN40278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000317">
        <property type="protein sequence ID" value="MRN69142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN40278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="67" mass="7383" checksum="E764A60A245AEE0F" modified="2020-06-17" version="1">MGATNDDRGGGHHPTEKDIVEKDSIKVVPVISTYFCVFVTYGDGNSTYHADIQAENHFKIISRVITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK20</accession>
    <name>A0A6A8FK20_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">FIO04_01680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="WJXC01000054">
        <property type="protein sequence ID" value="MRN68390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MRN68390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="408" mass="45446" checksum="4C422AB8629F208B" modified="2020-06-17" version="1">MANEKVVLAYSGGLDTSVCIRYLQTLHKFDVISLTVDCGQNEDFEVIEKKALAIGAIKHIFVDGKEEFAENYVIPSIKSNGLYEDKYPLATALARPLISAKLVEEAHHHGATAVAHGCTGKGNDQIRFDVTIRALDPHLKIIAPIRDMNLTRDLEMKFAQEQDIPISSEAKKYSVDLNIWGRAIEGGMVEDASSEPPTDAFQFVKFDNENADYLELEFENGIPVAADGQRMKIINLIGYVNDKAGSLGVGIMDHIEDRMVGIKSREIYEAPAAVVIVEAHKDLEKMVLTSHELRFKRVVDEQWSWLVYSGLWKDPLRSHLDKFIDATQKKVSGKVKLKMQMGSLRVVGRESQHSLYRNELATYTAGSTFDQSLAKGFVELWGLQSTVANMIDRRQRSEDNKNGGGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FK92</accession>
    <name>A0A6A8FK92_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO02_07980</name>
        <name evidence="4" type="ORF">FIO04_02845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AHI_AL_Thaum01</strain>
            <strain evidence="3">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000163">
        <property type="protein sequence ID" value="MRN40964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000115">
        <property type="protein sequence ID" value="MRN68617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="2">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN40964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MRN68617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="78" mass="8298" checksum="ACE3B511BDC0A6E0" modified="2020-06-17" version="1">MATQAYCVKCKAKRDMKDEKQVTMKNGQGAISGICTVCGTKMFKIGGGGKKIAKAKAASKKPTTRTAKVKAKSTSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKA6</accession>
    <name>A0A6A8FKA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO02_02710</name>
        <name evidence="6" type="ORF">FIO03_04000</name>
        <name evidence="7" type="ORF">FIO04_04590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
            <strain evidence="5">AHI_AL_Thaum02</strain>
            <strain evidence="6">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXE01000028">
        <property type="protein sequence ID" value="MRN39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXD01000114">
        <property type="protein sequence ID" value="MRN61204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000233">
        <property type="protein sequence ID" value="MRN68959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MRN61204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN68959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="319" mass="35599" checksum="1016510999FEACCD" modified="2020-06-17" version="1">MLAVEAVQVYKLYKGSNYAALNNVSVDVEPGQIFTLLGRNGAGKTTFVRICATQLAPTKGIVRVLGYDILKEAGKIRNLISVVPQESRPLRALTPWDHVYNWLQIRGESKYDAKKKTEKILHKLELYEAKDTPAMNLSGGMKQKILVAMAMATDAQLLFLDEPTIGLDPVSRRQVWSAIKDWKNEGKSILLTTHYMDEAEMLSDSIVIIDKGRVIADGTMRDLRKIIPQNIRIDIAKDSMDIELLKSYGSVVDTGTGTLRVFTFESTIKEISDFAIKKNLSFTVSPITLDDVFVSLVGKNTPDTEDDHRNTSINYDNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKD7</accession>
    <name>A0A6A8FKD7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000235">
        <property type="protein sequence ID" value="MRN68963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="43" mass="4537" checksum="12BD3AEBCEF96AC8" modified="2020-06-17" version="1" fragment="single">TGLGLFISKSIIEAHGGKMWAENNANGDKGAKFTFSLPLTNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKE7</accession>
    <name>A0A6A8FKE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_02350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000086">
        <property type="protein sequence ID" value="MRN68520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="190" mass="20750" checksum="93D0E88C1C9D9573" modified="2020-06-17" version="1" fragment="single">GYGLNGAFEDLAMEEIKAQFETNLFGVIRVTQAVLPIMRKQKSGIIVNISSGAGRFGYPGGSAYVSTKFAIEGLSESMAYELEPFGIRVVLVEPGVIKTNFVNSIVAAKKSQDPNSPYAQLMQNVATSFQHMIEGGSSTDVVAKVVLKAVTSENPTLRYLAGKDVETWIEGKKSMSDEEFYKMMKENLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKH3</accession>
    <name>A0A6A8FKH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000408">
        <property type="protein sequence ID" value="MRN69312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="194" mass="21606" checksum="92D3DBE7428B5F5C" modified="2020-06-17" version="1">MSISIGALLLFTVTGAFLIATIATPIFPNFAYAHLTGDRTQQWINPQDNVKIQFTYEPEKPLIGSPTELKFSVQNLQTGQHLKDLFAKVTIINGQRIFKFNNLTVSDGDFSVNSTFPNEGTYQVILRINSKDYAIALASFRVFVPFQPLGTINLNYTIPLLLPAALAGIIGVIVIATFLIIVKREYKKRHSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKH9</accession>
    <name>A0A6A8FKH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000412">
        <property type="protein sequence ID" value="MRN69322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="64" mass="7590" checksum="E3FB4F3E857C74B1" modified="2020-06-17" version="1">MRVKGQILWTAMARRISTMRAISNKQKDRIREQDTFDSYRWPYQVATFTNPSGADERHSSYGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKI0</accession>
    <name>A0A6A8FKI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_04860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000257">
        <property type="protein sequence ID" value="MRN69013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="25396" checksum="BE20080EE130DB5D" modified="2020-06-17" version="1" fragment="single">MTCIDGFSIRYLDYDNVKHVSDKPRVVLLLHGIGASAERWLPVVPGLSRHFRVVVPDIIGFGYSDKPTVEYTMDFFLSFLQKFLDNLNIPAASVVGSSFGGWIAMEFAIRFSRRIDKLVLAAPAGRMQSSTHVLDQYIMAALYPTRENALRAFMDMSYDPSGVTEDTVIDFVNRMRLPNAKYAFMSTLLGIRDSPNLSDRLPKLLVPTLFIWGDNDNMIPMQYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKL0</accession>
    <name>A0A6A8FKL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_03350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000146">
        <property type="protein sequence ID" value="MRN68717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="139" mass="15691" checksum="C8FD901E99E3D856" modified="2020-06-17" version="1">MEPISLANILGAISNENALAVFKTIADTKGDTDILRTKLNITRKQYYSRISGLLKTGLVKRKNGRYSLTVFGELVYDAAMTLEKAFNNNNYWKLKAIDSFEIAPDQSHELSIVERNKIIETLLRDDEKIKDILIAKLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKM8</accession>
    <name>A0A6A8FKM8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FIO04_06700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="WJXC01000446">
        <property type="protein sequence ID" value="MRN69372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MRN69372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="327" mass="38291" checksum="2372708AFD8A10F5" modified="2020-06-17" version="1">MDTVDKQLLNEIQWVFPLTDRPYLEISKRYNISEKDVMQRTSHLKEIGLIRQINAIFDTRRLGYKSALVAFVVKPDKLNHVAEEVNKHPGVSHNYERNHEFNMWFTLAVPPYADIKMDLERMASIDGVMKYRVLPTLKLYKIGVRLDMVNEDAKMPEPTDKVKTLNPRKFNLTERDKEFIRELQKDLKVIAEPFKELAHTLGITTSQLFAKAKEYEQLGVMRRFAAILRHRDAGFTANGMVVWKVPDFKIDEVGNKLAAFPQVSHCYRRPIYPDWQFNLFSMVHARTIEAAEKITVQMSESIGIKDYKILFSSREFKKERVKYFEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKN0</accession>
    <name>A0A6A8FKN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_02760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000109">
        <property type="protein sequence ID" value="MRN68600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN68600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="175" mass="19215" checksum="81220D33F01B46B2" modified="2020-06-17" version="1">MIHSSLPDYVSGMSIYQTMTYSVILIMVFIITFLGILSMSSVHAKVLQPSQSQPQSLPPPSSLLTITSQKQFNEWQKESDHAEASGDNAAETNATDKMALTDCVNELVLSRNGTLDFPALYSKLINTNSTAHFPSSGLDICDNLFSGWFKGPDAIIKPMLPIVEAYLKVRGYAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKP1</accession>
    <name>A0A6A8FKP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000464">
        <property type="protein sequence ID" value="MRN69398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="157" mass="18098" checksum="BB62B235C37D63AB" modified="2020-06-17" version="1" fragment="single">MFGRGRIKSGDYVFVVHKDQNYNKLVIGRVQSANGKIIQVRGTYIRPTGLIQRVESGYAMGRPKEVLQNPDPNNCIFMLIDRVETGDFNGDFDQGISKAVWINEKRFFVLDGWIRENLPDMFADVLRADTEQERLAARTTLIEKMNSLYEKDLKDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKS6</accession>
    <name>A0A6A8FKS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF167 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO03_08225</name>
        <name evidence="3" type="ORF">FIO04_03665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
            <strain evidence="2">AHI_AL_Thaum03</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXD01000362">
        <property type="protein sequence ID" value="MRN62007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000166">
        <property type="protein sequence ID" value="MRN68777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000480209">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN62007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000480209"/>
        </source>
    </evidence>
    <sequence length="55" mass="6221" checksum="8554F571ED5132B1" modified="2020-06-17" version="1">MGNEIIISIKSEPTHRKANKEMIKKISDFFGVPENSIHIISGLTSRKTIIEIQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKU1</accession>
    <name>A0A6A8FKU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000317">
        <property type="protein sequence ID" value="MRN69143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="123" mass="12674" checksum="8C853DA1CFC0C684" modified="2020-06-17" version="1">MTSGSFLAAVIIIFTFLVTASITMVYASSSNIETTDSKSSSSTLSSSSSHSKPANITTQESKSNSSADYMTGNKAGKIDGSVGIRDAGAACANLNGTRLNQCIQGYNTGFNSLCATTKFGCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKV9</accession>
    <name>A0A6A8FKV9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mvk</name>
        <name evidence="12" type="ORF">FIO04_05600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2"/>
    <dbReference type="EMBL" id="WJXC01000325">
        <property type="protein sequence ID" value="MRN69159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MRN69159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="257" mass="27565" checksum="2785500D64B682C6" modified="2020-06-17" version="1" fragment="single">KEAKTILAPLCECARLVLSERGCNLGLDIELVSNLPESVGLGSSAACCVAITAAVDSLFHEPDRYWVCAKAAESERLIHKDSSGADCNISTFGGMMYFVKSEGFKNIYPKKELSLGLINTGKKHSTANLVYSVKKFRDINRFSFKVLASLSNSICQKAFAALKEGDEQMLGNLMSQAHVLLQEIGVSDKTINELVALCLTNGAWGAKLTGAGGGGSIIVLVPPNEVRLKTFFDGIRKNGWGSESIPVKVDYDGVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKW7</accession>
    <name>A0A6A8FKW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_03865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000178">
        <property type="protein sequence ID" value="MRN68817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN68817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="337" mass="36627" checksum="D43881427E9492C9" modified="2020-06-17" version="1">MKAIDIKDELESNASSVNQYILSSLEGDPIELYRASSHYIKSGGKRLRPFLLIKSSEMFGGNLRRALPAAAAVELVHNFSLVHDDIMDNDDMRHSVQTVHKHYGMPLAILAGDILFSKAFELLAVHGRAKGIPEKAICEMVAKLSSACIQVCEGQATDVHMASMNDELSIDSPQYINMISKKTAALFELSCALGVLSAPNSSAIDVERLSWFGRNIGIAFQLVDDLIGITGDPKLTGKAVGNDLREGKKTYPILLALRNAKGENRSKILKIFGRKNASASDLKEAVGTISTIGIDQEIRLAARTHIEKAVQSLADYADSEAKRALESSASFIVERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKY3</accession>
    <name>A0A6A8FKY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000342">
        <property type="protein sequence ID" value="MRN69193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="225" mass="25429" checksum="C6226C3ABC5946E8" modified="2020-06-17" version="1">MKSQKCNIAIFDTFKTRNNKITGEARRQRGIIAHLATERSPELRTRTSIARIIADRHGILWQNIYSGIFRDLDEVLIPSGVVIEGGRLPLRRGPKALQMEGVPFYELSETGLLVASSIEEVGPSRTKMLESYIRSLPSGTPDYEIMREGILLLVRFFPSFACKIINEYVRAFTLGLIEGITPMDISKLRSVISAQIGLEKELIESFDRLQSDQKQTISRFINLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FKZ6</accession>
    <name>A0A6A8FKZ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FIO04_07400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="WJXC01000537">
        <property type="protein sequence ID" value="MRN69508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MRN69508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="98" mass="11291" checksum="DB738854B428DC01" modified="2020-06-17" version="1" fragment="single">ELDDNILTKLDVIYVTRIQKERFPDPQEYEKVKGTYTVDSNTLRKAKPDVSVMHPMPRMQEISHSIDNTKNAIYFKQAAYGKELRAALLALVLNENPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL19</accession>
    <name>A0A6A8FL19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IMP dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_07370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000532">
        <property type="protein sequence ID" value="MRN69502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="191" mass="19907" checksum="30967C02A6DE976F" modified="2020-06-17" version="1" fragment="single">GVDAVKVGVGSGSICITRVITGSGVPQLTAVMDSIKVAKEYNIPIISDGGIRTSGDSTKALAAGASTVMVGSLFGGTDESPGKTIVKNGKKYKMYRGMASFYASLGRKYREEGGQTADADDLNDYVPEGVEAMVPYKGSVVEIIRQAVGGIKSGLSYCGAKTISEMQSNAEFIKITPAGYTESHPHDVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL40</accession>
    <name>A0A6A8FL40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000368">
        <property type="protein sequence ID" value="MRN69243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="397" mass="45657" checksum="CC2D3708E7835CA2" modified="2020-06-17" version="1" fragment="single">MKIAELRHLDGVKGKIEVGDTELILTITPDEESHVIPQVIHSNVKQLVDQQKHLFEILWKKAIPAEQKIREIEEGIEPVETKVVEDYEEILNHLKYRIERASQRSVCSSIGGLQLVYNNFFHSYKKMLDRHRNKGSGREQGSSSTVRWVTIIDKESVDLVKKFLDAGIQMRHVRYLPPINFAVDNKYFDATIEKMEGGKIMHSLLSSNDSVYVNHYSSLFEQLWDNGIDAVTRIRDIEEGIDLANIEIIQNPQEGIKRAWNLIRTAKEEALIMFSTPNAFRRQVHMGVLWLLNETAKEHPDAKIKILIPTDAQITKTIKEAKLESPQIDFRIYEHGLIIRITIVIVDKKECMIVESKDDTKDSSYNAAGLSTYSSSKSIVMSYTSIFESLWKQTELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FL90</accession>
    <name>A0A6A8FL90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_04480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000225">
        <property type="protein sequence ID" value="MRN68937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN68937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="142" mass="15934" checksum="857D35A1010E5A3B" modified="2020-06-17" version="1">MILHDDNHLHIDGQDPIADWLVRSMRTAQTGSIKLDIEGQPAVKIDIINYGNKIMVDLLQPVFFRTPEDETGLFDKLKTAKEFAKKLTDNGMTISFLRRGKEAITLGKDAKPTLSKIITRSDDVQINSVTQTGNLKRDLKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLC1</accession>
    <name>A0A6A8FLC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FIO04_06445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000413">
        <property type="protein sequence ID" value="MRN69323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MRN69323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="323" mass="36449" checksum="E9F911ACCA5C97F1" modified="2020-06-17" version="1" fragment="single">MILKINSLHKSGKALMGRYKKNPILLPNKDVWWESKAVFNPAILYDGKKVHMLYRAIGEYEQYISRFGYACSTDGFTFERKNEIAFGPTEGYEKYGIEDPRLVPIDNQLYFSYVVLSDYVVKGPVGSTALAITNDFHNYTRLGIITSKGSDNKDVVLFPEKINQKYVLLHRPRSWVGPKFGIDKPSIWIAEGNTLSNFEKNTILMKPEQDWEELKIGSGPPPIKTKHGWLLIYHGVDKDLIYRTGAALLDLNNPGKVIARTKEPVLQPQESYERIGNVNNVVFPTGACVIDEKLHVYYGGADKVCCLAVVELNALLQYILNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLL6</accession>
    <name>A0A6A8FLL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-pyruvoyl tetrahydropterin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FIO04_05235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000291">
        <property type="protein sequence ID" value="MRN69087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MRN69087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="272" mass="30807" checksum="9C34E7F45386D58C" modified="2020-06-17" version="1">MERVVLDKDIRYLDNNGNLLRSRAEFSISKLLSFLGITYEYDASLSFKDGTSAKIDFKTGNRYIEIVDSKADMDKFKLIKKELPDVDVIALGHSKYAAKVNELDSLFFYDSNHSSHSGSIFIEDPSLAFDYAHILPQVEKCSILHGHTSTVMVEIIGQMTNNLVIDFSEAKKIIKDTLNVIDHKFFIDKKYLQKEDDLYYFISFDGPRGYFNLQLPKLTTFLLPGEATVETLSTEIIKLLAPKMPPNVEALGVYIYEGVNKGAHIIAEVKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLN9</accession>
    <name>A0A6A8FLN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_06990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000486">
        <property type="protein sequence ID" value="MRN69429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="79" mass="8607" checksum="1C2CF7986E01E257" modified="2020-06-17" version="1">MFVVPADSPIEFGRKKVKLKGGTFIDGFPSVGLANAIASEWFVHSLATELVAVLDSPGFPSLSIIQKWYSKFSCNNLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FLR3</accession>
    <name>A0A6A8FLR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_05490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000315">
        <property type="protein sequence ID" value="MRN69137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="52" mass="5884" checksum="1B3E72CF933C5F54" modified="2020-06-17" version="1">MKGTIAVDKTEKVGITLPKSILQRIDKVRGDIPRSTYIRRAVEVYLKQGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FM86</accession>
    <name>A0A6A8FM86_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FIO02_08435</name>
        <name evidence="14" type="ORF">FIO04_05605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">AHI_AL_Thaum01</strain>
            <strain evidence="13">AHI_AL_Thaum02</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3"/>
    <dbReference type="EMBL" id="WJXE01000181">
        <property type="protein sequence ID" value="MRN41053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WJXC01000325">
        <property type="protein sequence ID" value="MRN69160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000487867">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="12">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MRN41053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MRN69160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000487867"/>
        </source>
    </evidence>
    <sequence length="255" mass="28036" checksum="8F26BFBE6CDBBDC2" modified="2020-06-17" version="1">MLLMKLGGSVITFKEKPLSPNFKAIKDLSRVLASVQMPAVFVHGGGSFGHYWSVKYKMHTKPDGYDLRGISIVHESMIALNEIIVNSLIKEGANPYAVMPSMFTNGFRPISTKIEELRTIAKGGIIPITFGDVVHVNSRNYSIFSGDALMTILAKVLMPTKTIFLVNVDGLYKDPKTREIIREINNATYKSIEFSKMLTDVTGGMSRKIREAFKIAASGIDVLLVNGLKPQRILDAIGGIDFDGTIIRGIKKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMC3</accession>
    <name>A0A6A8FMC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence damage-inducible protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_05755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000341">
        <property type="protein sequence ID" value="MRN69190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="260" mass="28721" checksum="3EEF34817F8B798F" modified="2020-06-17" version="1" fragment="single">GDELLSGITINTNAYWISQKITEVGGSVRRITAIRDDVDEISLGVRDSISRKPDWLILSGGLGPTYDDKTMQGVARGLSLELALDKTALDMLKKSYARHSMTYELNEIRLKMAKIPVGSNPIQNPVGSAPSVLIESGETKIVCLPGVPEEMKAIFLESILPQMKKIIGDFHIVESRYETIGVSEAMLAPILSEIVESNPPDSIYLKTHPLGYTIDSNNKKPQMRVQIVSKGKDKAEVQSRFNKISRMLLEEISRLNGNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMI0</accession>
    <name>A0A6A8FMI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000373">
        <property type="protein sequence ID" value="MRN69250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="81" mass="9064" checksum="FB4BBA881E4F17BE" modified="2020-06-17" version="1">MLVAYLLITCNAGLDEEVLSKLNELPEVVEANRVSFGPYDIIVKVEADTIERFNQTVGFDIKRIRNITSAVTLIKNIEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMM5</accession>
    <name>A0A6A8FMM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FIO04_06265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000395">
        <property type="protein sequence ID" value="MRN69290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="39"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MRN69290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="235" mass="26656" checksum="24154619A3F3BA22" modified="2020-06-17" version="1" fragment="single">MTVYIVVVIALFALLVLGFFSSESIYLTQAQSQTPKNDKVVILTFGDGWKTQYTNAKPILDRYGFKGSFFITCTLVGLPLRMSWQDIVSLYNDGNDIGSKTMTYKTLTKLSSSGLNYEVGQSKQCLRDHGVNTTLFATPRGLGGDNATVINEIAKYYDFAINGFSNLMYLKCDGWKRYSSQTDCRTYFDNGTLTYANRYSVREWSHNSVDLAYMHNDTSIFKIFVQEVNSQNKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2020-10-07" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6A8FMU4</accession>
    <name>A0A6A8FMU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FIO04_07545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrosopumilales archaeon</name>
        <dbReference type="NCBI Taxonomy" id="2026768"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrosopumilales</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genome of Dominant Archaeon in High Arctic Active Layer.</title>
            <authorList>
                <person name="Sun E.W.-H."/>
                <person name="Hajirezaie S."/>
                <person name="Dooner M."/>
                <person name="Tatiana V.A."/>
                <person name="Layton A."/>
                <person name="Chauhan A."/>
                <person name="Pfiffner S.M."/>
                <person name="Whyte L.G."/>
                <person name="Onstott T.C."/>
                <person name="Lau M.C.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AHI_AL_Thaum01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WJXC01000562">
        <property type="protein sequence ID" value="MRN69537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000470911">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MRN69537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000470911"/>
        </source>
    </evidence>
    <sequence length="191" mass="20740" checksum="E47AC916CF0BF70C" modified="2020-06-17" version="1" fragment="single">MVAFSKSNILLLLVIAAIGTSLSILSYQYSSVTAKDIAEIASQEIRSNARIEAHDLSELLIHDIQSITNNLRTLAATPAIHNNITTLTQVLIDSAQASTKVLTDGYYLLDQNGRLIAWSNSNGSSVGKSKSLDLGSLEYFIVPKKTHSPYYTSVMTSADNIPRLYIAFPIMVPDAKFDKGGSIIVTKTFKG</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>